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Aliases for ATF7IP2 Gene

Aliases for ATF7IP2 Gene

  • Activating Transcription Factor 7 Interacting Protein 2 2 3
  • MCAF2 3 4 6
  • MBD1-Containing Chromatin-Associated Factor 2 3 4
  • ATF7-Interacting Protein 2 3 4
  • Activating Transcription Factor 7-Interacting Protein 2 3
  • MBD1-Containing Chromatin Associated Factor 2 3

External Ids for ATF7IP2 Gene

Previous GeneCards Identifiers for ATF7IP2 Gene

  • GC16P010582
  • GC16P010479
  • GC16P010491
  • GC16P010489
  • GC16P010430

Summaries for ATF7IP2 Gene

GeneCards Summary for ATF7IP2 Gene

ATF7IP2 (Activating Transcription Factor 7 Interacting Protein 2) is a Protein Coding gene. An important paralog of this gene is ATF7IP.

UniProtKB/Swiss-Prot for ATF7IP2 Gene

  • Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. The complex formed with MBD1 and SETDB1 represses transcription and probably couples DNA methylation and histone H3 Lys-9 trimethylation (H3K9me3) activity (Probable).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATF7IP2 Gene

Genomics for ATF7IP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ATF7IP2 Gene

Start:
10,326,434 bp from pter
End:
10,483,638 bp from pter
Size:
157,205 bases
Orientation:
Plus strand

Genomic View for ATF7IP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATF7IP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATF7IP2 Gene

Proteins for ATF7IP2 Gene

  • Protein details for ATF7IP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5U623-MCAF2_HUMAN
    Recommended name:
    Activating transcription factor 7-interacting protein 2
    Protein Accession:
    Q5U623
    Secondary Accessions:
    • B2RNR2
    • Q53EZ7
    • Q658U2
    • Q6IS97
    • Q8N9X8
    • Q9H9L6

    Protein attributes for ATF7IP2 Gene

    Size:
    682 amino acids
    Molecular mass:
    75764 Da
    Quaternary structure:
    • Interacts with MBD1, SETDB1 and SP1. Probably forms a complex with SETDB1 and MBD1
    SequenceCaution:
    • Sequence=BAB14209.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ATF7IP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATF7IP2 Gene

Proteomics data for ATF7IP2 Gene at MOPED

Post-translational modifications for ATF7IP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ATF7IP2 Gene

Domains for ATF7IP2 Gene

Protein Domains for ATF7IP2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q5U623

UniProtKB/Swiss-Prot:

MCAF2_HUMAN :
  • Q5U623
Domain:
  • Contains 1 fibronectin type-III domain.
Family:
  • Belongs to the MCAF family.
genes like me logo Genes that share domains with ATF7IP2: view

No data available for Gene Families for ATF7IP2 Gene

Function for ATF7IP2 Gene

Molecular function for ATF7IP2 Gene

UniProtKB/Swiss-Prot Function: Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. The complex formed with MBD1 and SETDB1 represses transcription and probably couples DNA methylation and histone H3 Lys-9 trimethylation (H3K9me3) activity (Probable).

Gene Ontology (GO) - Molecular Function for ATF7IP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ATF7IP2: view

Phenotypes for ATF7IP2 Gene

genes like me logo Genes that share phenotypes with ATF7IP2: view

Animal Model Products

CRISPR Products

miRNA for ATF7IP2 Gene

miRTarBase miRNAs that target ATF7IP2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ATF7IP2 Gene

Localization for ATF7IP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATF7IP2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATF7IP2 Gene COMPARTMENTS Subcellular localization image for ATF7IP2 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ATF7IP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ATF7IP2: view

Pathways for ATF7IP2 Gene

SuperPathways for ATF7IP2 Gene

No Data Available

Interacting Proteins for ATF7IP2 Gene

Gene Ontology (GO) - Biological Process for ATF7IP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ATF7IP2: view

No data available for Pathways by source for ATF7IP2 Gene

Transcripts for ATF7IP2 Gene

Unigene Clusters for ATF7IP2 Gene

Activating transcription factor 7 interacting protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATF7IP2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ATF7IP2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATF7IP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1:
SP2: -

Relevant External Links for ATF7IP2 Gene

GeneLoc Exon Structure for
ATF7IP2
ECgene alternative splicing isoforms for
ATF7IP2

Expression for ATF7IP2 Gene

mRNA expression in normal human tissues for ATF7IP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ATF7IP2 Gene

This gene is overexpressed in Testis (5.6) and Liver (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ATF7IP2 Gene

SOURCE GeneReport for Unigene cluster for ATF7IP2 Gene Hs.513343

genes like me logo Genes that share expressions with ATF7IP2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ATF7IP2 Gene

Orthologs for ATF7IP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ATF7IP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATF7IP2 35
  • 99.26 (n)
  • 99.11 (a)
ATF7IP2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATF7IP2 35
  • 81.72 (n)
  • 71.92 (a)
ATF7IP2 36
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATF7IP2 35
  • 82.47 (n)
  • 72.36 (a)
ATF7IP2 36
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atf7ip2 35
  • 78.83 (n)
  • 66.37 (a)
Atf7ip2 16
Atf7ip2 36
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATF7IP2 36
  • 40 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATF7IP2 36
  • 38 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atf7ip2 35
  • 78.69 (n)
  • 63.92 (a)
lizard
(Anolis carolinensis)
Reptilia ATF7IP2 36
  • 20 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii atf7ip2 36
  • 22 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta wde 36
  • 8 (a)
OneToMany
Species with no ortholog for ATF7IP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATF7IP2 Gene

ENSEMBL:
Gene Tree for ATF7IP2 (if available)
TreeFam:
Gene Tree for ATF7IP2 (if available)

Paralogs for ATF7IP2 Gene

Paralogs for ATF7IP2 Gene

Selected SIMAP similar genes for ATF7IP2 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for ATF7IP2 Gene

genes like me logo Genes that share paralogs with ATF7IP2: view

Variants for ATF7IP2 Gene

Sequence variations from dbSNP and Humsavar for ATF7IP2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs10221 -- 10,483,438(+) ACGGG(A/G)CCCAA utr-variant-3-prime, nc-transcript-variant
rs1075879 -- 10,391,020(+) GGGTG(C/T)AGTAG intron-variant
rs1124896 -- 10,409,640(-) agatt(A/G)tcctg intron-variant
rs1348506 -- 10,389,353(+) ATCTA(C/T)GAATG intron-variant
rs1444195 -- 10,399,150(+) GCAAA(A/C)TCTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATF7IP2 Gene

Variant ID Type Subtype PubMed ID
nsv905337 CNV Loss 21882294
nsv519263 CNV Gain+Loss 19592680
nsv457405 CNV Loss 19166990
nsv905338 CNV Loss 21882294
nsv833139 CNV Loss 17160897
esv2713960 CNV Deletion 23290073

Relevant External Links for ATF7IP2 Gene

HapMap Linkage Disequilibrium report
ATF7IP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATF7IP2 Gene

Disorders for ATF7IP2 Gene

Relevant External Links for ATF7IP2

Genetic Association Database (GAD)
ATF7IP2
Human Genome Epidemiology (HuGE) Navigator
ATF7IP2
genes like me logo Genes that share disorders with ATF7IP2: view

No data available for UniProtKB/Swiss-Prot for ATF7IP2 Gene

Publications for ATF7IP2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins. (PMID: 15691849) Ichimura T. … Nakao M. (J. Biol. Chem. 2005) 3 4
  4. Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs. (PMID: 20195266) Adkins D.E. … van den Oord E.J. (Mol. Psychiatry 2011) 3 48
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4

Products for ATF7IP2 Gene

Sources for ATF7IP2 Gene

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