Aliases for ATF7IP Gene
External Ids for ATF7IP Gene
Previous GeneCards Identifiers for ATF7IP Gene
ATF7IP is a multifunctional nuclear protein that associates with heterochromatin. It can act as a transcriptional coactivator or corepressor depending upon its binding partners (summary by Liu et al., 2009 [PubMed 19106100]).[supplied by OMIM, Nov 2010]
GeneCards Summary for ATF7IP Gene
ATF7IP (Activating Transcription Factor 7 Interacting Protein) is a Protein Coding gene. Diseases associated with ATF7IP include Neural Tube Defects and Mycobacterium Tuberculosis, Susceptibility To Mycobacterium Tuberculosis, Protection Against, Included. Among its related pathways are Chromatin organization and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include ATPase activity and transcription corepressor activity. An important paralog of this gene is ATF7IP2.
UniProtKB/Swiss-Prot for ATF7IP Gene
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Required to stimulate histone methyltransferase activity of SETDB1 and facilitate the conversion of dimethylated to trimethylated H3 Lys-9 (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 Lys-9 trimethylation (H3K9me3). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells.