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Aliases for ATF7IP Gene

Aliases for ATF7IP Gene

  • Activating Transcription Factor 7 Interacting Protein 2 3
  • MCAF1 3 4 6
  • MCAF 3 4 6
  • MBD1-Containing Chromatin-Associated Factor 1 3 4
  • ATFa-Associated Modulator 3 4
  • ATF7-Interacting Protein 3 4
  • ATF-Interacting Protein 3 4
  • ATF-IP 3 4
  • P621 3 4
  • AM 3 6
  • Activating Transcription Factor 7-Interacting Protein 1 3
  • HAM 4

External Ids for ATF7IP Gene

Previous GeneCards Identifiers for ATF7IP Gene

  • GC12P014317
  • GC12P014663
  • GC12P014418
  • GC12P014468
  • GC12P014409
  • GC12P014518

Summaries for ATF7IP Gene

Entrez Gene Summary for ATF7IP Gene

  • ATF7IP is a multifunctional nuclear protein that associates with heterochromatin. It can act as a transcriptional coactivator or corepressor depending upon its binding partners (summary by Liu et al., 2009 [PubMed 19106100]).[supplied by OMIM, Nov 2010]

GeneCards Summary for ATF7IP Gene

ATF7IP (Activating Transcription Factor 7 Interacting Protein) is a Protein Coding gene. GO annotations related to this gene include transcription corepressor activity and ATPase activity. An important paralog of this gene is ATF7IP2.

UniProtKB/Swiss-Prot for ATF7IP Gene

  • Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Required to stimulate histone methyltransferase activity of SETDB1 and facilitate the conversion of dimethylated to trimethylated H3 Lys-9 (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 Lys-9 trimethylation (H3K9me3). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells.

Gene Wiki entry for ATF7IP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATF7IP Gene

Genomics for ATF7IP Gene

Regulatory Elements for ATF7IP Gene

Genomic Location for ATF7IP Gene

Start:
14,365,632 bp from pter
End:
14,502,935 bp from pter
Size:
137,304 bases
Orientation:
Plus strand

Genomic View for ATF7IP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATF7IP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATF7IP Gene

Proteins for ATF7IP Gene

  • Protein details for ATF7IP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6VMQ6-MCAF1_HUMAN
    Recommended name:
    Activating transcription factor 7-interacting protein 1
    Protein Accession:
    Q6VMQ6
    Secondary Accessions:
    • F5GX74
    • G3V1U0
    • Q4G0T9
    • Q6P3T3
    • Q86XW5
    • Q9NVJ9
    • Q9NWC2
    • Q9Y4X8

    Protein attributes for ATF7IP Gene

    Size:
    1270 amino acids
    Molecular mass:
    136394 Da
    Quaternary structure:
    • Interacts with MBD1; the interaction is enhanced when MBD1 is sumoylated. Probably forms a complex with SETDB1 and MBD1. Interacts with SUMO ubiquitin-like proteins (SUMO1, SUNO2 and SUMO3), with a preference for SUMO2 and SUMO3. Interacts with SP1, ATF7 and ZHX1. Interacts with the general transcription machinery, including ERCC2, ERCC3, GTF2E1, GTF2E2 and POLR2A. Interacts with Epstein-Barr virus BRLF1/Rta protein, leading to promote and regulate host genes in Epstein-Barr virus-infected cells.
    SequenceCaution:
    • Sequence=AAH37312.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AK001001; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AK001001; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BAA91751.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ATF7IP Gene

    Alternative splice isoforms for ATF7IP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATF7IP Gene

Proteomics data for ATF7IP Gene at MOPED

Post-translational modifications for ATF7IP Gene

  • Ubiquitination at Lys568, Lys597, and Lys645
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ATF7IP Gene

Domains for ATF7IP Gene

Protein Domains for ATF7IP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ATF7IP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6VMQ6

UniProtKB/Swiss-Prot:

MCAF1_HUMAN :
  • Q6VMQ6
Domain:
  • Contains 1 fibronectin type-III domain.
Family:
  • Belongs to the MCAF family.
genes like me logo Genes that share domains with ATF7IP: view

No data available for Gene Families for ATF7IP Gene

Function for ATF7IP Gene

Molecular function for ATF7IP Gene

UniProtKB/Swiss-Prot Function: Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Required to stimulate histone methyltransferase activity of SETDB1 and facilitate the conversion of dimethylated to trimethylated H3 Lys-9 (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 Lys-9 trimethylation (H3K9me3). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells.

Gene Ontology (GO) - Molecular Function for ATF7IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity IEA --
GO:0005515 protein binding IPI 12665582
GO:0016887 ATPase activity IEA --
genes like me logo Genes that share ontologies with ATF7IP: view

Phenotypes for ATF7IP Gene

genes like me logo Genes that share phenotypes with ATF7IP: view

miRNA for ATF7IP Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ATF7IP Gene

Localization for ATF7IP Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATF7IP Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATF7IP Gene COMPARTMENTS Subcellular localization image for ATF7IP gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ATF7IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12665582
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ATF7IP: view

Pathways for ATF7IP Gene

SuperPathways for ATF7IP Gene

No Data Available

Gene Ontology (GO) - Biological Process for ATF7IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006200 obsolete ATP catabolic process --
GO:0006306 DNA methylation IDA 12665582
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ATF7IP: view

No data available for Pathways by source for ATF7IP Gene

Transcripts for ATF7IP Gene

Unigene Clusters for ATF7IP Gene

Activating transcription factor 7 interacting protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATF7IP Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g · 9h · 9i ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^
SP1: - - - - - -
SP2:
SP3: - - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - - - - - - - - - - -
SP6:
SP7: - - - - - - -
SP8: - -
SP9: - - - - -
SP10: - - - - - - - -
SP11: - - - - - - - -
SP12: - - - -
SP13: -

ExUns: 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b
SP1: - - -
SP2: - - -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for ATF7IP Gene

GeneLoc Exon Structure for
ATF7IP
ECgene alternative splicing isoforms for
ATF7IP

Expression for ATF7IP Gene

mRNA expression in normal human tissues for ATF7IP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATF7IP Gene

SOURCE GeneReport for Unigene cluster for ATF7IP Gene Hs.591151

mRNA Expression by UniProt/SwissProt for ATF7IP Gene

Q6VMQ6-MCAF1_HUMAN
Tissue specificity: Detected at low levels in breast, lung and stomach; highly up-regulated in the corresponding cancerous tissues (at protein level).
genes like me logo Genes that share expressions with ATF7IP: view

No data available for mRNA differential expression in normal tissues for ATF7IP Gene

Orthologs for ATF7IP Gene

This gene was present in the common ancestor of animals.

Orthologs for ATF7IP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATF7IP 35
  • 99.69 (n)
  • 99.45 (a)
ATF7IP 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATF7IP 35
  • 88.15 (n)
  • 85.84 (a)
ATF7IP 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATF7IP 35
  • 90.32 (n)
  • 87.9 (a)
ATF7IP 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atf7ip 35
  • 79.7 (n)
  • 76.09 (a)
Atf7ip 16
Atf7ip 36
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATF7IP 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATF7IP 36
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atf7ip 35
  • 79.95 (n)
  • 76.38 (a)
chicken
(Gallus gallus)
Aves ATF7IP 35
  • 71.4 (n)
  • 66.82 (a)
ATF7IP 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATF7IP 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atf7ip 35
  • 63.88 (n)
  • 60.23 (a)
Str.10534 35
zebrafish
(Danio rerio)
Actinopterygii atf7ip 36
  • 31 (a)
OneToOne
wufa12g02 35
fruit fly
(Drosophila melanogaster)
Insecta wde 36
  • 13 (a)
OneToMany
Species with no ortholog for ATF7IP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATF7IP Gene

ENSEMBL:
Gene Tree for ATF7IP (if available)
TreeFam:
Gene Tree for ATF7IP (if available)

Paralogs for ATF7IP Gene

Paralogs for ATF7IP Gene

genes like me logo Genes that share paralogs with ATF7IP: view

Variants for ATF7IP Gene

Sequence variations from dbSNP and Humsavar for ATF7IP Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs962504 -- 14,457,505(+) taccc(A/G)aaccc intron-variant
rs2041983 -- 14,404,994(+) CTTTT(G/T)TTAAT intron-variant
rs2058875 -- 14,408,168(+) TGTTT(C/T)TTGAA intron-variant
rs2058876 -- 14,408,477(+) CTATG(C/T)AAATT intron-variant
rs2058877 -- 14,456,148(+) AATTG(C/G)TGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATF7IP Gene

Variant ID Type Subtype PubMed ID
nsv528068 CNV Gain 19592680
nsv832335 CNV Loss 17160897
nsv469119 CNV Gain 19166990
nsv470269 CNV Gain 18288195
esv22134 CNV Gain 19812545

Relevant External Links for ATF7IP Gene

HapMap Linkage Disequilibrium report
ATF7IP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATF7IP Gene

Disorders for ATF7IP Gene

(1) University of Copenhagen DISEASES for ATF7IP Gene

Relevant External Links for ATF7IP

Genetic Association Database (GAD)
ATF7IP
Human Genome Epidemiology (HuGE) Navigator
ATF7IP
genes like me logo Genes that share disorders with ATF7IP: view

No data available for UniProtKB/Swiss-Prot for ATF7IP Gene

Publications for ATF7IP Gene

  1. Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins. (PMID: 15691849) Ichimura T. … Nakao M. (J. Biol. Chem. 2005) 3 4 23
  2. MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity. (PMID: 19106100) Liu L. … Nakao M. (J. Biol. Chem. 2009) 3 4 23
  3. A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening. (PMID: 10976766) Gunther M. … Brison O. (Mol. Cell. Biochem. 2000) 2 3 4
  4. A murine ATFa-associated factor with transcriptional repressing activity. (PMID: 10777215) De Graeve F. … Kedinger C. (Oncogene 2000) 2 3
  5. Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3. (PMID: 12659632) Yamada K. … Miyamoto K. (Biochem. J. 2003) 3 4

Products for ATF7IP Gene

Sources for ATF7IP Gene

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