Aliases for ATF7IP Gene
External Ids for ATF7IP Gene
Previous GeneCards Identifiers for ATF7IP Gene
ATF7IP is a multifunctional nuclear protein that associates with heterochromatin. It can act as a transcriptional coactivator or corepressor depending upon its binding partners (summary by Liu et al., 2009 [PubMed 19106100]).[supplied by OMIM, Nov 2010]
GeneCards Summary for ATF7IP Gene
ATF7IP (Activating Transcription Factor 7 Interacting Protein) is a Protein Coding gene. Diseases associated with ATF7IP include germ cell cancer and testicular cancer. Among its related pathways are Chromatin organization and RNA Polymerase I Promoter Opening. GO annotations related to this gene include ATPase activity and transcription corepressor activity. An important paralog of this gene is ATF7IP2.
UniProtKB/Swiss-Prot for ATF7IP Gene
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Required to stimulate histone methyltransferase activity of SETDB1 and facilitate the conversion of dimethylated to trimethylated H3 Lys-9 (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 Lys-9 trimethylation (H3K9me3). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells.