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ATF7IP Gene

protein-coding   GIFtS: 56
GCID: GC12P014518

Activating Transcription Factor 7 Interacting Protein

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Activating Transcription Factor 7 Interacting Protein1 2     MBD1-Containing Chromatin-Associated Factor 12 3
MCAF2 3 5     AM2 5
MCAF12 3 5     Activating Transcription Factor 7-Interacting Protein 12
ATF-IP2 3     p6212
ATF-Interacting Protein2 3     P6213
ATF7-Interacting Protein2 3     hAM3
ATFa-Associated Modulator2 3     

External Ids:    HGNC: 200921   Entrez Gene: 557292   Ensembl: ENSG000001716817   OMIM: 6136445   UniProtKB: Q6VMQ63   

Export aliases for ATF7IP gene to outside databases

Previous GC identifers: GC12P014317 GC12P014663 GC12P014418 GC12P014468 GC12P014409


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ATF7IP Gene:
ATF7IP is a multifunctional nuclear protein that associates with heterochromatin. It can act as a transcriptional
coactivator or corepressor depending upon its binding partners (summary by Liu et al., 2009 (PubMed
19106100)).(supplied by OMIM, Nov 2010)

GeneCards Summary for ATF7IP Gene:
ATF7IP (activating transcription factor 7 interacting protein) is a protein-coding gene. Diseases associated with ATF7IP include germ cell cancer, and testicular cancer. GO annotations related to this gene include ATPase activity and transcription corepressor activity. An important paralog of this gene is ATF7IP2.

UniProtKB/Swiss-Prot: MCAF1_HUMAN, Q6VMQ6
Function: Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates
transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the
context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1.
Required to stimulate histone methyltransferase activity of SETDB1 and facilitate the conversion of dimethylated
to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and
couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3). Facilitates telomerase TERT and TERC
gene expression by SP1 in cancer cells

Gene Wiki entry for ATF7IP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_009714.18  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ATF7IP gene promoter:
         Elk-1   AML1a   Lmo2   YY1   POU2F1   POU2F1b   POU2F1a   ZID   Pax-4a   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATF7IP promoter sequence
   Search Chromatin IP Primers for ATF7IP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATF7IP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.1   Ensembl cytogenetic band:  12p13.1   HGNC cytogenetic band: 12p13.1

ATF7IP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATF7IP gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P014518:  view genomic region     (about GC identifiers)

Start:
14,518,610 bp from pter      End:
14,651,697 bp from pter
Size:
133,088 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MCAF1_HUMAN, Q6VMQ6 (See protein sequence)
Recommended Name: Activating transcription factor 7-interacting protein 1  
Size: 1270 amino acids; 136394 Da
Subunit: Interacts with MBD1; the interaction is enhanced when MBD1 is sumoylated. Probably forms a complex with
SETDB1 and MBD1. Interacts with SUMO ubiquitin-like proteins (SUMO1, SUNO2 and SUMO3), with a preference for
SUMO2 and SUMO3. Interacts with SP1, ATF7 and ZHX1. Interacts with the general transcription machinery, including
ERCC2, ERCC3, GTF2E1, GTF2E2 and POLR2A. Interacts with Epstein-Barr virus BRLF1/Rta protein, leading to promote
and regulate host genes in Epstein-Barr virus-infected cells
Sequence caution: Sequence=AAH37312.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AK001001; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AK001001; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=BAA91751.1; Type=Erroneous
initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for ATF7IP:
2RPQ (3D)    
Secondary accessions: Q4G0T9 Q6P3T3 Q86XW5 Q9NVJ9 Q9NWC2 Q9Y4X8
Alternative splicing: 2 isoforms:  Q6VMQ6-1   Q6VMQ6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ATF7IP: NX_Q6VMQ6

Explore proteomics data for ATF7IP at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys568, Lys597, Lys645
  • Modification sites at PhosphoSitePlus

  • See ATF7IP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001273443.1  NP_001273444.1  NP_060649.3  NP_851997.1  

    ENSEMBL proteins: 
     ENSP00000440587   ENSP00000444620   ENSP00000443179   ENSP00000445955   ENSP00000444784  
     ENSP00000439279   ENSP00000445604   ENSP00000440440   ENSP00000443855   ENSP00000441483  
     ENSP00000439578   ENSP00000446260   ENSP00000414158   ENSP00000379575   ENSP00000443540  
     ENSP00000442958   ENSP00000439192   ENSP00000444589   ENSP00000437711   ENSP00000261168  

    ATF7IP Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR026085 ATF7-int
     IPR003961 Fibronectin_type3
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q6VMQ6

    ProtoNet protein and cluster: Q6VMQ6

    UniProtKB/Swiss-Prot: MCAF1_HUMAN, Q6VMQ6
    Similarity: Belongs to the MCAF family
    Similarity: Contains 1 fibronectin type-III domain


    ATF7IP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MCAF1_HUMAN, Q6VMQ6
    Function: Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates
    transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the
    context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1.
    Required to stimulate histone methyltransferase activity of SETDB1 and facilitate the conversion of dimethylated
    to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and
    couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3). Facilitates telomerase TERT and TERC
    gene expression by SP1 in cancer cells

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity IEA--
    GO:0005515protein binding IPI12665582
    GO:0016887ATPase activity IEA--
         
    ATF7IP for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for ATF7IP:
     Decreased Wnt reporter activit  Increased gamma-H2AX phosphory  Wnt reporter upregulated 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ATF7IP
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    miRNA
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    miRTarBase miRNAs that target ATF7IP:
    hsa-mir-744-5p (MIRT037643), hsa-mir-23b-3p (MIRT046291), hsa-mir-320b (MIRT036221), hsa-mir-320a (MIRT044675)

    Block miRNA regulation of human, mouse, rat ATF7IP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ATF7IP (see all 10):
    hsa-miR-3910 hsa-miR-142-3p hsa-miR-1290 hsa-miR-7-2* hsa-miR-124 hsa-miR-7-1* hsa-miR-506 hsa-miR-580
    SwitchGear 3'UTR luciferase reporter plasmidATF7IP 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ATF7IP

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MCAF1_HUMAN, Q6VMQ6: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12665582
    GO:0005667transcription factor complex IEA--

    ATF7IP for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ATF7IP
    Interactions:

        GeneGlobe Interaction Network for ATF7IP

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    Selected Interacting proteins for ATF7IP (Q6VMQ61, 2, 3 ENSP000002611684) via UniProtKB, MINT, STRING, and/or I2D (see all 85)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HLA-BP304612, 3MINT-61906 I2D: score=2 I2D: score=1 
    C7orf55-LUC7L2Q9Y3832, 3MINT-61916 I2D: score=3 
    FAM47E-STBD1O952102, 3MINT-61889 I2D: score=3 
    LUC7L2Q9Y3832, 3MINT-61916 I2D: score=3 
    STBD1O952102, 3MINT-61889 I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006200ATP catabolic process ----
    GO:0006306DNA methylation IDA12665582
    GO:0006351transcription, DNA-templated IEA--
    GO:0016032viral process IEA--

    ATF7IP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ATF7IP (MCAF1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ATF7IP gene (4 alternative transcripts): 
    NM_001286514.1  NM_001286515.1  NM_018179.4  NM_181352.1  

    Unigene Cluster for ATF7IP:

    Activating transcription factor 7 interacting protein
    Hs.591151  [show with all ESTs]
    Unigene Representative Sequence: NM_018179
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000539659 ENST00000537653(uc010shs.1 uc001rbu.3) ENST00000538511
    ENST00000545723 ENST00000543189(uc001rbv.1) ENST00000536444 ENST00000542967
    ENST00000534828 ENST00000535132 ENST00000544627(uc010sht.1 uc001rby.4)
    ENST00000541654 ENST00000542991 ENST00000541056 ENST00000539057 ENST00000545769
    ENST00000428217 ENST00000396279(uc001rbz.1) ENST00000542514
    miRNA
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    Block miRNA regulation of human, mouse, rat ATF7IP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ATF7IP (see all 10):
    hsa-miR-3910 hsa-miR-142-3p hsa-miR-1290 hsa-miR-7-2* hsa-miR-124 hsa-miR-7-1* hsa-miR-506 hsa-miR-580
    SwitchGear 3'UTR luciferase reporter plasmidATF7IP 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ATF7IP
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    GenScript: all cDNA clones in your preferred vector: ATF7IP (NM_018179)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATF7IP
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ATF7IP
      QuantiTect SYBR Green Assays in human, mouse, rat ATF7IP
      QuantiFast Probe-based Assays in human, mouse, rat ATF7IP

    Additional mRNA sequence: 

    AF425650.1 AJ242978.1 AK001550.1 AK025060.1 AK027575.1 AK074868.1 AK299320.1 AK304184.1 
    AK308062.1 BC037312.2 BC053625.1 BC063855.1 BC067269.1 BX648096.1 

    16 DOTS entries:

    DT.212589  DT.100647156  DT.91749801  DT.91882399  DT.95279524  DT.99961066  DT.40242578  DT.121207422 
    DT.95279520  DT.95279518  DT.121207379  DT.121207382  DT.86852743  DT.100841641  DT.92023294  DT.99926205 

    Selected AceView cDNA sequences (see all 298):

    BQ689817 BG461174 BQ881185 AW445138 BM768057 AI902692 AA368409 BM719228 
    AA970362 AA601527 CB121219 AL697881 AI479983 CK903643 AA393948 AK125103 
    AI871106 AA337979 BE886093 BX341605 BF512759 AK025060 CN480694 AW297583 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ATF7IP (see all 13)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g · 9h · 9i ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^
    SP1:                                -     -     -     -     -     -                                                                                             
    SP2:                                                                                                                                                            
    SP3:        -     -     -     -     -     -     -     -     -     -                                                                                             
    SP4:        -     -     -     -     -     -     -     -     -     -                                                                                             
    SP5:        -     -     -     -     -     -     -     -     -     -                 -     -     -     -     -     -     -     -                                 

    ExUns: 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b
    SP1:                          -                       -     -                     
    SP2:                          -                       -     -                     
    SP3:                          -                                                   
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for ATF7IP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ATF7IP expression in normal human tissues (normalized intensities)      ATF7IP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAAATCCAC
    ATF7IP Expression
    About this image


    ATF7IP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    ATF7IP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ATF7IP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591151

    UniProtKB/Swiss-Prot: MCAF1_HUMAN, Q6VMQ6
    Tissue specificity: Detected at low levels in breast, lung and stomach; highly up-regulated in the corresponding
    cancerous tissues (at protein level)

        Custom PCR Arrays for ATF7IP
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATF7IP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ATF7IP gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atf7ip1 , 5 activating transcription factor 7 interacting protein1, 5 79.7(n)1
    76.09(a)1
      6 (66.59 cM)5
    543431  NM_019426.21  NP_062299.21 
     1365188515 
    chicken
    (Gallus gallus)
    Aves ATF7IP1 activating transcription factor 7 interacting protein 71.4(n)
    66.82(a)
      417966  NM_001012813.1  NP_001012831.1 
    lizard
    (Anolis carolinensis)
    Reptilia ATF7IP6
    activating transcription factor 7 interacting prot...
    58(a)
    1 ↔ 1
    GL343714.1(115135-214110)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480569342   -- 74.4(n)    48056934 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa12g022 wufa12g02 74.16(n)   335064  BI708275.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta wde6
    windei
    13(a)
    1 → many
    2R(6687924-6696430)


    ENSEMBL Gene Tree for ATF7IP (if available)
    TreeFam Gene Tree for ATF7IP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ATF7IP gene
    ATF7IP22  
    1 SIMAP similar gene for ATF7IP using alignment to 18 protein entries:     MCAF1_HUMAN (see all proteins):
    ATF7IP2

    ATF7IP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ATF7IP (see all 2663)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs680160451,2
    C--14345674(+) GGTAC-/TTT   
      
    /TTTTT
    TTTTT
    2 -- int1 cds11NA 2
    rs740678251,2
    C,F--14516631(+) TGATGT/AACTAT 1 -- us2k12Minor allele frequency- A:0.06WA 120
    rs2009908181,2
    C--14516650(+) TAATA-/AATAAATT 1 -- us2k10--------
    rs1434509031,2
    C--14516855(+) GAGATG/TACCTC 1 -- us2k10--------
    rs1123829671,2
    C--14516910(+) TTTCTTTTTTT  
      TTTC
    /-
    TTTTT
    1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1816653101,2
    --14516917(+) TTTTTC/TTTCTT 1 -- us2k10--------
    rs1115801141,2
    C--14517044(+) AGGACC/TACAGG 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs45502751,2
    C,A--14517089(+) TTGTAT/CTTTTA 1 -- us2k12Minor allele frequency- C:0.25NA CSA 4
    rs1862406511,2
    --14517170(+) GCCTCC/TCAAAG 1 -- us2k10--------
    rs24173441,2
    C,F,A--14517191(+) ACAGGC/TGTGAG 1 -- us2k15Minor allele frequency- T:0.33NA CSA 9

    HapMap Linkage Disequilibrium report for ATF7IP (14518610 - 14651697 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ATF7IP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832335CNV Loss17160897
    esv22134CNV Gain19812545
    nsv470269CNV Gain18288195
    nsv528068CNV Gain19592680
    nsv469119CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ATF7IP
    DNA2.0 Custom Variant and Variant Library Synthesis for ATF7IP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613644    OMIM disorders: --

    4 diseases for ATF7IP:    About MalaCards
    germ cell cancer    testicular cancer    schizophrenia    malaria

    1 disease from the University of Copenhagen DISEASES database for ATF7IP:
    Testicular cancer

    ATF7IP for disorders           About GeneDecksing

    Genetic Association Database (GAD): ATF7IP
    Human Genome Epidemiology (HuGE) Navigator: ATF7IP (1 document)

    Export disorders for ATF7IP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ATF7IP gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with ATF7IP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening. (PubMed id 10976766)1, 2, 3 Gunther M.... Brison O. (Mol. Cell. Biochem. 2000)
    2. Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins. (PubMed id 15691849)1, 2, 9 Ichimura T.... Nakao M. (J. Biol. Chem. 2005)
    3. MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity. (PubMed id 19106100)1, 2, 9 Liu L.... Nakao M. (J. Biol. Chem. 2009)
    4. Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer. (PubMed id 20543847)1, 4 Turnbull C.... Rahman N. (Nat. Genet. 2010)
    5. Structure of the small ubiquitin-like modifier (SUMO)-interacting motif of MBD1-containing chromatin-associated factor 1 bound to SUMO- 3. (PubMed id 18842587)1, 2 Sekiyama N.... Shirakawa M. (J. Biol. Chem. 2008)
    6. Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation. (PubMed id 16757475)1, 2 Uchimura Y.... Saitoh H. (J. Biol. Chem. 2006)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    8. Activation of Sp1-mediated transcription by Rta of Epstein-Barr virus via an interaction with MCAF1. (PubMed id 16314315)1, 2 Chang L.-K....Liu S.-T. (Nucleic Acids Res. 2005)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55729 HGNC: 20092 AceView: ATF7IP Ensembl:ENSG00000171681 euGenes: HUgn55729
    ECgene: ATF7IP H-InvDB: ATF7IP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ATF7IP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ATF7IP gene:
    Search GeneIP for patents involving ATF7IP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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