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Aliases for ATF7 Gene

Aliases for ATF7 Gene

  • Activating Transcription Factor 7 2 3 4 5
  • Transcription Factor ATF-A 3 4
  • ATFA 3 4
  • CAMP-Dependent Transcription Factor ATF-7 4

External Ids for ATF7 Gene

Previous GeneCards Identifiers for ATF7 Gene

  • GC12M053905
  • GC12M054022
  • GC12M053626
  • GC12M052196
  • GC12M050945

Summaries for ATF7 Gene

GeneCards Summary for ATF7 Gene

ATF7 (Activating Transcription Factor 7) is a Protein Coding gene. Diseases associated with ATF7 include penicilliosis and familial atrial fibrillation. Among its related pathways are Regulation of retinoblastoma protein and IL-2 Pathway. GO annotations related to this gene include nucleic acid binding and sequence-specific DNA binding. An important paralog of this gene is ATF2.

UniProtKB/Swiss-Prot for ATF7 Gene

  • Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5-GTGACGT[AG][AG]-3), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family.

  • Isoform 4/ATF-A0 acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter.

  • Isoform 5/ATF-4 acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.

Gene Wiki entry for ATF7 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATF7 Gene

Genomics for ATF7 Gene

Regulatory Elements for ATF7 Gene

Promoters for ATF7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ATF7 on UCSC Golden Path with GeneCards custom track

Genomic Location for ATF7 Gene

Chromosome:
12
Start:
53,507,856 bp from pter
End:
53,626,415 bp from pter
Size:
118,560 bases
Orientation:
Minus strand

Genomic View for ATF7 Gene

Genes around ATF7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATF7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATF7 Gene

Proteins for ATF7 Gene

  • Protein details for ATF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17544-ATF7_HUMAN
    Recommended name:
    Cyclic AMP-dependent transcription factor ATF-7
    Protein Accession:
    P17544
    Secondary Accessions:
    • A5D6Y4
    • B2RMP1
    • B4DQL4
    • Q13814
    • Q8IVR8
    • Q9UD83

    Protein attributes for ATF7 Gene

    Size:
    494 amino acids
    Molecular mass:
    52967 Da
    Quaternary structure:
    • Homodimer; binds DNA as homodimer. Heterodimer; heterodimerizes with other members of ATF family and with JUN family members. Interacts with JNK2; the interaction does not phosphorylate ATF7 but acts as a docking site for other ATF-associated partners such as JUN family members. Interacts (via its transactivation domain) with TAF12 (isoforms TAFII15 and TAFII20); the interaction potentiates the transactivation activity (isoform TAFII20 only) and is inhibited by ATF7 sumoylation. Interacts with TAF4; the interaction inhibits the TAF12-dependent transactivation. Interacts with adenovirus 2 E1A; the interaction enhances the ATF7-mediated viral transactivation activity which requires the zinc-binding domains of both E1A and ATF7. Interacts with MAPK9; the interaction does not phosphorylate ATF7 but acts as a docking site for ATF7-associated partners such as JUN.

    Alternative splice isoforms for ATF7 Gene

neXtProt entry for ATF7 Gene

Proteomics data for ATF7 Gene at MOPED

Post-translational modifications for ATF7 Gene

  • On EGF stimulation, phosphorylated first on Thr-53 allowing subsequent phosphorylation on Thr-51. This latter phosphorylation prevents sumoylation, increases binding to TAF12 and enhances transcriptional activity.
  • Sumoylation delays nuclear localization and inhibits transactivation activity through preventing binding to TAF12. RANBP2 appears to be the specific E3 ligase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for ATF7 Gene

Domains & Families for ATF7 Gene

Gene Families for ATF7 Gene

Suggested Antigen Peptide Sequences for ATF7 Gene

Graphical View of Domain Structure for InterPro Entry

P17544

UniProtKB/Swiss-Prot:

ATF7_HUMAN :
  • Contains 1 bZIP (basic-leucine zipper) domain.
  • Belongs to the bZIP family.
  • Contains 1 C2H2-type zinc finger.
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family.
Similarity:
  • Contains 1 C2H2-type zinc finger.
genes like me logo Genes that share domains with ATF7: view

Function for ATF7 Gene

Molecular function for ATF7 Gene

UniProtKB/Swiss-Prot Function:
Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5-GTGACGT[AG][AG]-3), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family.
UniProtKB/Swiss-Prot Function:
Isoform 4/ATF-A0 acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter.
UniProtKB/Swiss-Prot Function:
Isoform 5/ATF-4 acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.

Gene Ontology (GO) - Molecular Function for ATF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 8288576
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 8288576
GO:0005515 protein binding IPI 10376527
GO:0008134 transcription factor binding IDA 10376527
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ATF7: view
genes like me logo Genes that share phenotypes with ATF7: view

Animal Models for ATF7 Gene

MGI Knock Outs for ATF7:

Animal Model Products

  • Taconic Biosciences Mouse Models for ATF7

miRNA for ATF7 Gene

miRTarBase miRNAs that target ATF7
Targeted motifs for ATF7 Gene
HOMER Transcription Factor Regulatory Elements motif ATF7
  • Consensus sequence: NGRTGACGTCAY Submotif: canonical Cell Type: 3T3L1 GEO ID: GSE56872

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for ATF7 Gene

Localization for ATF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATF7 Gene

Nucleus. Nucleus, nucleoplasm. Note=Mainly nucleoplasmic. Restricted distribution to the perinuculear region. The sumoylated form locates to the nuclear periphery.
Isoform 5: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATF7 Gene COMPARTMENTS Subcellular localization image for ATF7 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ATF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ATF7: view

Pathways & Interactions for ATF7 Gene

genes like me logo Genes that share pathways with ATF7: view

Pathways by source for ATF7 Gene

Gene Ontology (GO) - Biological Process for ATF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with ATF7: view

No data available for SIGNOR curated interactions for ATF7 Gene

Drugs & Compounds for ATF7 Gene

(3) Drugs for ATF7 Gene - From: DrugBank, Novoseek, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pseudoephedrine Approved Pharma Target 447
cyclic amp Experimental Pharma 0
genes like me logo Genes that share compounds with ATF7: view

Transcripts for ATF7 Gene

Unigene Clusters for ATF7 Gene

Activating transcription factor 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATF7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c
SP1: - - - - - - -
SP2: - - - - -
SP3: - -
SP4: -
SP5:
SP6: -

Relevant External Links for ATF7 Gene

GeneLoc Exon Structure for
ATF7
ECgene alternative splicing isoforms for
ATF7

Expression for ATF7 Gene

mRNA expression in normal human tissues for ATF7 Gene

Protein differential expression in normal tissues from HIPED for ATF7 Gene

This gene is overexpressed in NK cells (15.7), Fetal testis (13.4), Fetal ovary (12.3), and Testis (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ATF7 Gene



SOURCE GeneReport for Unigene cluster for ATF7 Gene Hs.12286

mRNA Expression by UniProt/SwissProt for ATF7 Gene

P17544-ATF7_HUMAN
Tissue specificity: Expressed in heart, lung and skeletal muscle. Isoform 4 is expressed in various tissues including heart, brain, placenta, lung and skeletal muscle. Highest levels in skeletal muscle. Lowest in lung and placenta.
genes like me logo Genes that share expression patterns with ATF7: view

Protein tissue co-expression partners for ATF7 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ATF7 Gene

Orthologs for ATF7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ATF7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATF7 35
  • 99.93 (n)
  • 100 (a)
ATF7 36
  • 100 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 98 (a)
OneToMany
ATF7 35
  • 94.81 (n)
  • 98.27 (a)
dog
(Canis familiaris)
Mammalia ATF7 35
  • 94.96 (n)
  • 98.96 (a)
-- 36
  • 99 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Atf7 16
Atf7 35
  • 92.62 (n)
  • 97.32 (a)
Atf7 36
  • 97 (a)
ManyToMany
ATF7 36
  • 97 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 62 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 56 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Atf7 35
  • 91.65 (n)
  • 97.1 (a)
chicken
(Gallus gallus)
Aves ATF7 35
  • 78.26 (n)
  • 90.83 (a)
-- 36
  • 91 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 90 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia atf7 35
  • 73.59 (n)
  • 82.66 (a)
Str.18007 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9788 35
zebrafish
(Danio rerio)
Actinopterygii atf7a 36
  • 70 (a)
ManyToMany
atf7b 36
  • 61 (a)
ManyToMany
atf7a 35
  • 68.57 (n)
  • 74.05 (a)
wufa97a09 35
Species with no ortholog for ATF7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATF7 Gene

ENSEMBL:
Gene Tree for ATF7 (if available)
TreeFam:
Gene Tree for ATF7 (if available)

Paralogs for ATF7 Gene

Paralogs for ATF7 Gene

(2) SIMAP similar genes for ATF7 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ATF7: view

Variants for ATF7 Gene

Sequence variations from dbSNP and Humsavar for ATF7 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs8938 -- 53,543,094(-) TTCTT(A/C)CAGGG intron-variant, utr-variant-3-prime
rs10655 -- 53,543,084(+) ACTAA(C/T)ACTCC intron-variant, utr-variant-3-prime
rs796751 -- 53,527,107(+) tgagc(C/T)gagat intron-variant
rs814157 -- 53,527,620(+) ctcta(C/T)taaaa intron-variant
rs1248072 -- 53,622,380(+) ctttg(A/G)gaggc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATF7 Gene

Variant ID Type Subtype PubMed ID
nsv53289 CNV Insertion 16902084
esv2672386 CNV Deletion 23128226
nsv526791 CNV Gain 19592680
nsv715 CNV Loss 18451855
esv2673908 CNV Deletion 23128226
esv2745909 CNV Deletion 23290073

Variation tolerance for ATF7 Gene

Residual Variation Intolerance Score: 31.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATF7 Gene

HapMap Linkage Disequilibrium report
ATF7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATF7 Gene

Disorders for ATF7 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ATF7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
penicilliosis
familial atrial fibrillation
  • atrial fibrillation, familial, 1
- elite association - COSMIC cancer census association via MalaCards
Search ATF7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ATF7

Genetic Association Database (GAD)
ATF7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATF7
genes like me logo Genes that share disorders with ATF7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ATF7 Gene

Publications for ATF7 Gene

  1. Isolation and characterization of two novel, closely related ATF cDNA clones from HeLa cells. (PMID: 1694576) Gaire M. … Kedinger C. (Nucleic Acids Res. 1990) 2 3 4 67
  2. A functional interaction between ATF7 and TAF12 that is modulated by TAF4. (PMID: 15735663) Hamard P.J. … Chatton B. (Oncogene 2005) 3 23
  3. Retinoblastoma protein interacts with ATF2 and JNK/p38 in stimulating the transforming growth factor-beta2 promoter. (PMID: 11566021) Li H. … Wicks W.D. (Arch. Biochem. Biophys. 2001) 3 23
  4. ATF-7, a novel bZIP protein, interacts with the PRL-1 protein-tyrosine phosphatase. (PMID: 11278933) Peters C.S. … Diamond R.H. (J. Biol. Chem. 2001) 2 3
  5. Role of the ATFa/JNK2 complex in Jun activation. (PMID: 10376527) De Graeve F. … Chatton B. (Oncogene 1999) 3 23

Products for ATF7 Gene

Sources for ATF7 Gene

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