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ATF7 Gene

protein-coding   GIFtS: 59
GCID: GC12M053905

Activating Transcription Factor 7

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Activating Transcription Factor 71 2 3
Transcription Factor ATF-A2 3
ATFA2 3
Cyclic AMP-Dependent Transcription Factor ATF-72
CAMP-Dependent Transcription Factor ATF-73

External Ids:    HGNC: 7921   Entrez Gene: 110162   Ensembl: ENSG000001706537   OMIM: 6063715   UniProtKB: P175443   

Export aliases for ATF7 gene to outside databases

Previous GC identifers: GC12M054022 GC12M053626 GC12M052196 GC12M050945


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ATF7 Gene:
ATF7 (activating transcription factor 7) is a protein-coding gene. Diseases associated with ATF7 include retinoblastoma, and breast cancer. GO annotations related to this gene include transcription factor binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ENSG00000267281.

UniProtKB/Swiss-Prot: ATF7_HUMAN, P17544
Function: Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus:
5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Activator of the
NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates
transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized
with members of the JUN family
Function: Isoform 4/ATF-A0 acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter
Function: Isoform 5/ATF-4 acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities.
It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing
activation

Gene Wiki entry for ATF7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ATF7 gene promoter:
         TBP   MEF-2   CUTL1   AREB6   FOXO4   HOXA5   HSF2   Pax-4a   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATF7 promoter sequence
   Search Chromatin IP Primers for ATF7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATF7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13

ATF7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATF7 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M053905:  view genomic region     (about GC identifiers)

Start:
53,901,640 bp from pter      End:
54,020,199 bp from pter
Size:
118,560 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ATF7_HUMAN, P17544 (See protein sequence)
Recommended Name: Cyclic AMP-dependent transcription factor ATF-7  
Size: 494 amino acids; 52967 Da
Subunit: Homodimer; binds DNA as homodimer. Heterodimer; heterodimerizes with other members of ATF family and with
JUN family members. Interacts with JNK2; the interaction does not phosphorylate ATF7 but acts as a docking site
for other ATF-associated partners such as JUN family members. Interacts (via its transactivation domain) with
TAF12 (isoforms TAFII15 and TAFII20); the interaction potentiates the transactivation activity (isoform TAFII20
only) and is inhibited by ATF7 sumoylation. Interacts with TAF4; the interaction inhibits the TAF12-dependent
transactivation. Interacts with adenovirus 2 E1A; the interaction enhances the ATF7-mediated viral
transactivation activity which requires the zinc-binding domains of both E1A and ATF7. Interacts with MAPK9; the
interaction does not phosphorylate ATF7 but acts as a docking site for ATF7-associated partners such as JUN
Secondary accessions: A5D6Y4 B2RMP1 B4DQL4 Q13814 Q8IVR8 Q9UD83
Alternative splicing: 6 isoforms:  P17544-1   P17544-2   P17544-3   P17544-4   P17544-5   P17544-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ATF7: NX_P17544

Explore proteomics data for ATF7 at MOPED

Post-translational modifications: 

  • On EGF stimulation, phosphorylated first on Thr-53 allowing subsequent phosphorylation on Thr-51. This latter
    phosphorylation prevents sumoylation, increases binding to TAF12 and enhances transcriptional activity1
  • Sumoylation delays nuclear localization and inhibits transactivation activity through preventing binding to TAF12.
    RANBP2 appears to be the specific E3 ligase1
  • Ubiquitination2 at Lys400
  • Modification sites at PhosphoSitePlus

  • See ATF7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001123532.1  NP_001193611.1  NP_001193612.1  NP_006847.1  

    ENSEMBL proteins: 
     ENSP00000449938   ENSP00000399465   ENSP00000387406   ENSP00000465850   ENSP00000449817  
     ENSP00000468623   ENSP00000456858   ENSP00000465192   ENSP00000329212   ENSP00000404880  

    ATF7 Human Recombinant Protein Products:

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    OriGene Purified Protein for ATF7
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    Novus Biologicals ATF7 Proteins
    Novus Biologicals ATF7 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for ATF7

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    Abcam antibodies for ATF7
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    ThermoFisher Antibodies for ATF7
    LSBio Antibodies in human, mouse, rat for ATF7

    ATF7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for ATF7
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    Cloud-Clone Corp. ELISAs for ATF7
    Cloud-Clone Corp. CLIAs for ATF7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bZIP: basic leucine zipper proteins

    5 InterPro protein domains:
     IPR004827 bZIP
     IPR015880 Znf_C2H2-like
     IPR016378 TF_cAMP-dep
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P17544

    ProtoNet protein and cluster: P17544

    1 Blocks protein domain: IPB011616 bZIP transcription factor

    UniProtKB/Swiss-Prot: ATF7_HUMAN, P17544
    Similarity: Belongs to the bZIP family
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain
    Similarity: Contains 1 C2H2-type zinc finger


    ATF7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATF7_HUMAN, P17544
    Function: Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus:
    5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Activator of the
    NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates
    transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized
    with members of the JUN family
    Function: Isoform 4/ATF-A0 acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter
    Function: Isoform 5/ATF-4 acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities.
    It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing
    activation

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI10376527
    GO:0008134transcription factor binding IDA10376527
    GO:0043565sequence-specific DNA binding IEA--
         
    ATF7 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for ATF7:
     Decreased number of cells in m  Decreased viability  G0/1 arrest  Increased G1 DNA content 

         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Atf7):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  growth/size/body 
     hematopoietic system  homeostasis/metabolism  liver/biliary system  mortality/aging  nervous system 
     normal 

    ATF7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ATF7: Atf7tm1Sis Atf7tm1Nicj

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ATF7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ATF7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ATF7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ATF7

    miRNA
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    miRTarBase miRNAs that target ATF7:
    hsa-mir-16-5p (MIRT031445), hsa-mir-769-5p (MIRT016096)

    Block miRNA regulation of human, mouse, rat ATF7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ATF7 (see all 107):
    hsa-miR-642a hsa-miR-485-3p hsa-miR-3142 hsa-miR-149 hsa-miR-489 hsa-miR-4326 hsa-miR-200b hsa-miR-3612
    SwitchGear 3'UTR luciferase reporter plasmidATF7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ATF7
    Predesigned siRNA for gene silencing in human, mouse, rat ATF7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ATF7

    Clone
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    OriGene clones in human, mouse for ATF7 (see all 18)
    OriGene ORF clones in mouse, rat for ATF7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): ATF7 (NM_001130059)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATF7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATF7

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    Browse ESI BIO Cell Lines and PureStem Progenitors for ATF7 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATF7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ATF7_HUMAN, P17544: Nucleus. Nucleus, nucleoplasm. Note=Mainly nucleoplasmic. Restricted distribution to the
    perinuculear region. The sumoylated form locates to the nuclear periphery
    ATF7_HUMAN, P17544: Isoform 5: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS8288576
    GO:0005654nucleoplasm IEA--
    GO:0005737cytoplasm IEA--
    GO:0034399nuclear periphery IDA17264123

    ATF7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ATF7 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1ERK Signaling
    MAPK Signaling0.58
    ILK Signaling0.49
    2TWEAK Pathway
    TNF Signaling0.55
    3TCR Signaling (Qiagen)
    ITK and TCR Signaling0.54
    4Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36
    5ErbB4 Pathway
    PI3K Signaling in B-Lymphocyte0.35

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ATF7 (see all 9)
        MAPK Signaling
    PI3K Signaling in B-Lymphocyte
    TNF Signaling
    iNOS Signaling
    SMAD Signaling Network

    1 BioSystems Pathway for ATF7
        Regulation of retinoblastoma protein


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ATF7
    Interactions:

        GeneGlobe Interaction Network for ATF7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ATF7 (P175441, 2, 3 ENSP000003292124) via UniProtKB, MINT, STRING, and/or I2D (see all 68)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    JDP2Q8WYK22, 3, ENSP000002675694MINT-6699684 MINT-6699624 I2D: score=2 STRING: ENSP00000267569
    JUNBP172752, 3MINT-6699684 MINT-6699624 I2D: score=1 
    JUNDP175352, 3MINT-6699684 MINT-6699624 I2D: score=1 
    OCIAD1Q9NX401, 3EBI-765623,EBI-2683029 I2D: score=1 
    TAF4O002683, ENSP000002529964I2D: score=3 STRING: ENSP00000252996
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IDA8288576
    GO:0016032viral process IEA--
    GO:0019048modulation by virus of host morphology or physiology ----

    ATF7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ATF7

    1 HMDB Compound for ATF7    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    2 Novoseek inferred chemical compound relationships for ATF7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cyclic amp 37.7 1 15735663 (1)
    leucine 35.6 2 7702840 (1), 8939888 (1)



    ATF7 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ATF7 gene (5 alternative transcripts): 
    NM_001130059.1  NM_001130060.1  NM_001206682.1  NM_001206683.1  NM_006856.2  

    Unigene Cluster for ATF7:

    Activating transcription factor 7
    Hs.12286  [show with all ESTs]
    Unigene Representative Sequence: NM_006856
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000548446(uc010sok.1) ENST00000420353(uc001sdz.3) ENST00000456903
    ENST00000551087 ENST00000546661 ENST00000588232 ENST00000551480 ENST00000588078
    ENST00000548118(uc001sea.4 uc001seb.4) ENST00000591397 ENST00000550373
    ENST00000589726 ENST00000328463(uc001sdy.3) ENST00000415113(uc010sol.2)

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    Selected qRT-PCR Assays for microRNAs that regulate ATF7 (see all 107):
    hsa-miR-642a hsa-miR-485-3p hsa-miR-3142 hsa-miR-149 hsa-miR-489 hsa-miR-4326 hsa-miR-200b hsa-miR-3612
    SwitchGear 3'UTR luciferase reporter plasmidATF7 3' UTR sequence
    Inhib. RNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): ATF7 (NM_001130059)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATF7
    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat ATF7

    Additional mRNA sequence: 

    AK298853.1 AK302907.1 AK310355.1 AK313507.1 BC032433.1 BC042363.1 BC127259.1 BC136302.1 
    BC140006.1 NR_073163.1 X52943.1 X57197.1 

    11 DOTS entries:

    DT.40252235  DT.109024  DT.95350377  DT.453071  DT.443798  DT.91723027  DT.121185200  DT.40254406 
    DT.410741  DT.40131562  DT.95084758 

    Selected AceView cDNA sequences (see all 57):

    BQ675296 W45531 BU552917 BX093800 BI829327 BQ073001 CB135343 BF817643 
    X57197 BX643397 BG203452 CB054833 BC032433 CB991315 BQ323296 BM825773 
    BI596298 BG325826 AI091123 BG113231 AA679547 CB160881 AL704402 AA701229 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ATF7 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c
    SP1:                    -                 -                 -     -     -                                               -     -                     
    SP2:                                      -                       -     -                                               -     -                     
    SP3:                    -                 -                                                                                                         
    SP4:                                      -                                                                                                         
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for ATF7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ATF7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCCCTGTGA
    ATF7 Expression
    About this image

    ATF7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ATF7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.12286

    UniProtKB/Swiss-Prot: ATF7_HUMAN, P17544
    Tissue specificity: Expressed in heart, lung and skeletal muscle. Isoform 4 is expressed in various tissues
    including heart, brain, placenta, lung and skeletal muscle. Highest levels in skeletal muscle. Lowest in lung and
    placenta

        Custom PCR Arrays for ATF7
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    QuantiFast Probe-based Assays in human, mouse, rat ATF7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATF7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for ATF7 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atf71 , 5 activating transcription factor 71, 5 92.62(n)1
    97.32(a)1
      15 (57.66 cM)5
    2239221  NM_146065.11  NP_666177.11 
     1025259465 
    chicken
    (Gallus gallus)
    Aves ATF71 activating transcription factor 7 78.26(n)
    90.83(a)
      769661  XM_003643835.2  XP_003643883.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    90(a)
    1 → many
    2(72968514-73099099)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.180072 Transcribed sequence with moderate similarity to protein more 78.02(n)    AL965564.2 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa97a092 Transcribed sequence with weak similarity to protein more 77.36(n)    AL915059.1 


    ENSEMBL Gene Tree for ATF7 (if available)
    TreeFam Gene Tree for ATF7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ATF7 gene
    ENSG000002672812  ATF22  CREB52  
    2 SIMAP similar genes for ATF7 using alignment to 4 protein entries:     ATF7_HUMAN (see all proteins):
    CREB5    ATF2

    ATF7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ATF7 (see all 1963)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1129612151,2
    F--53903569(+) ACAGGC/TGTGAG 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1171738401,2
    F--53903599(+) CCATAG/TTCTTT 1 -- int11Minor allele frequency- T:0.01NA 120
    rs1461372891,2
    C--53903712(+) GATACC/TATATT 1 -- int10--------
    rs1862029661,2
    --53903839(+) TTTTTG/TTGAGA 1 -- int10--------
    rs1112848451,2
    C,F--53903845(+) TGAGAC/TGGAGT 1 -- int11Minor allele frequency- T:0.50WA 2
    rs2018229391,2
    --53904308(+) TGTAA-/TC    
       CTAGC
    TCTTG
    1 -- int10--------
    rs1910078011,2
    --53904869(+) TCCAGA/GGACAC 1 -- int10--------
    rs118300381,2
    C,F,A,H--53905094(+) ACGGCA/GCGATC 1 -- int14Minor allele frequency- G:0.30NA WA 10
    rs1815024371,2
    --53905096(+) GGCACA/GATCTT 1 -- int10--------
    rs1489325611,2
    C--53905281(+) AACCCA/GCCTCA 1 -- int10--------

    HapMap Linkage Disequilibrium report for ATF7 (53901640 - 54020199 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ATF7:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2745909CNV Deletion23290073
    esv2672386CNV Deletion23128226
    esv2673908CNV Deletion23128226
    nsv53289CNV Insertion16902084
    nsv715CNV Loss18451855
    nsv526791CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ATF7
    DNA2.0 Custom Variant and Variant Library Synthesis for ATF7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606371    OMIM disorders: --

    2 diseases for ATF7:    
    About MalaCards
    retinoblastoma    breast cancer


    ATF7 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for ATF7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 43.7 3 7786026 (2), 11566021 (1)

    Genetic Association Database (GAD): ATF7

    Export disorders for ATF7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ATF7 gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with ATF7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of two novel, closely related ATF cDNA clones from HeLa cells. (PubMed id 1694576)1, 2, 3 Gaire M.... Kedinger C. (Nucleic Acids Res. 1990)
    2. A functional interaction between ATF7 and TAF12 that is modulated by TAF4. (PubMed id 15735663)1, 2, 9 Hamard P.J....Chatton B. (Oncogene 2005)
    3. Role of the ATFa/JNK2 complex in Jun activation. (PubMed id 10376527)1, 2, 9 De Graeve F.... Chatton B. (Oncogene 1999)
    4. A cytoplasmic negative regulator isoform of ATF7 impairs ATF7 and ATF2 phosphorylation and transcriptional activity. (PubMed id 21858082)1, 2 Diring J.... Chatton B. (PLoS ONE 2011)
    5. Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. (PubMed id 21998595)1, 4 N'Diaye A....Haiman C.A. (PLoS Genet. 2011)
    6. A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci. (PubMed id 20189936)1, 4 Okada Y....Kamatani N. (Hum. Mol. Genet. 2010)
    7. p38beta2-mediated phosphorylation and sumoylation of ATF7 are mutually exclusive. (PubMed id 18950637)1, 2 Camuzeaux B.... Chatton B. (J. Mol. Biol. 2008)
    8. Sumoylation delays the ATF7 transcription factor subcellular localization and inhibits its transcriptional activity. (PubMed id 17264123)1, 2 Hamard P.J.... Chatton B. (Nucleic Acids Res. 2007)
    9. ATF-7, a novel bZIP protein, interacts with the PRL-1 protein-tyrosine phosphatase. (PubMed id 11278933)1, 3 Peters C.S....Diamond R.H. (J. Biol. Chem. 2001)
    10. ATF-a0, a novel variant of the ATF/CREB transcription factor family, forms a dominant transcription inhibitor in ATF-a heterodimers. (PubMed id 8288576)1, 2 Pescini R....Hooft van Huijsduijnen R. (J. Biol. Chem. 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11016 HGNC: 792 AceView: ATF7 Ensembl:ENSG00000170653 euGenes: HUgn11016
    ECgene: ATF7 H-InvDB: ATF7

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ATF7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ATF7 gene:
    Search GeneIP for patents involving ATF7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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