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Aliases for ATF7 Gene

Aliases for ATF7 Gene

  • Activating Transcription Factor 7 2 3 4 5
  • Transcription Factor ATF-A 3 4
  • ATFA 3 4
  • Cyclic AMP-Dependent Transcription Factor ATF-7 3
  • CAMP-Dependent Transcription Factor ATF-7 4

External Ids for ATF7 Gene

Previous GeneCards Identifiers for ATF7 Gene

  • GC12M053905
  • GC12M054022
  • GC12M053626
  • GC12M052196
  • GC12M050945

Summaries for ATF7 Gene

GeneCards Summary for ATF7 Gene

ATF7 (Activating Transcription Factor 7) is a Protein Coding gene. Diseases associated with ATF7 include Penicilliosis and Familial Atrial Fibrillation. Among its related pathways are Regulation of retinoblastoma protein and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include nucleic acid binding and sequence-specific DNA binding. An important paralog of this gene is ENSG00000267281.

UniProtKB/Swiss-Prot for ATF7 Gene

  • Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5-GTGACGT[AG][AG]-3), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family.

  • Isoform 4 acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter.

  • Isoform 5 acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.

Gene Wiki entry for ATF7 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATF7 Gene

Genomics for ATF7 Gene

Regulatory Elements for ATF7 Gene

Enhancers for ATF7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F053530 0.6 FANTOM5 14.2 +96.1 96139 0.2 PKNOX1 MAP3K12 ATF7 NPFF TARBP2 ATP5G2 AMHR2 C12orf10 AAAS MFSD5 CALCOCO1
GH12F053674 1 FANTOM5 ENCODE 12 -51.1 -51070 5.4 CREB3L1 MLX DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D ZNF610 ATP5G2 SP1 IGFBP6 MAP3K12 AAAS ENSG00000258344 PFDN5 ENSG00000260470 ATF7 ZNF740
GH12F053740 0.4 FANTOM5 11.7 -113.1 -113130 0.3 PKNOX1 INSM2 ZNF76 KLF17 FEZF1 ZNF121 SCRT2 OVOL3 ZNF645 ZEB2 LOC105378250 ATP5G2 ATF7 HOXC6 CALCOCO1
GH12F053591 0.8 Ensembl ENCODE 11.3 +34.6 34615 1.2 ATF1 GLIS2 FOS NFYC ZHX2 REST TSHZ1 MAFF MYNN GLIS1 ATF7 ATP5G2 MAP3K12 TARBP2 NPFF LOC100419830 ENSG00000267281
GH12F053595 1.1 Ensembl ENCODE 11.2 +29.4 29420 3.6 PKNOX1 FEZF1 ZNF2 GLIS2 ZNF766 KLF7 ZNF263 REST TSHZ1 GLIS1 ATP5G2 ATF7 NPFF MAP3K12 TARBP2 PRR13 LOC100419830 ENSG00000267281
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ATF7 on UCSC Golden Path with GeneCards custom track

Promoters for ATF7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000244245 1215 4001 HDGF PKNOX1 ARNT MLX CREB3L1 WRNIP1 ARID4B SIN3A YBX1 FEZF1

Genomic Location for ATF7 Gene

Chromosome:
12
Start:
53,507,856 bp from pter
End:
53,626,415 bp from pter
Size:
118,560 bases
Orientation:
Minus strand

Genomic View for ATF7 Gene

Genes around ATF7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATF7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATF7 Gene

Proteins for ATF7 Gene

  • Protein details for ATF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17544-ATF7_HUMAN
    Recommended name:
    Cyclic AMP-dependent transcription factor ATF-7
    Protein Accession:
    P17544
    Secondary Accessions:
    • A5D6Y4
    • B2RMP1
    • B4DQL4
    • Q13814
    • Q8IVR8
    • Q9UD83

    Protein attributes for ATF7 Gene

    Size:
    494 amino acids
    Molecular mass:
    52967 Da
    Quaternary structure:
    • Homodimer; binds DNA as homodimer. Heterodimer; heterodimerizes with other members of ATF family and with JUN family members. Interacts with JNK2; the interaction does not phosphorylate ATF7 but acts as a docking site for other ATF-associated partners such as JUN family members. Interacts (via its transactivation domain) with TAF12 (isoforms TAFII15 and TAFII20); the interaction potentiates the transactivation activity (isoform TAFII20 only) and is inhibited by ATF7 sumoylation. Interacts with TAF4; the interaction inhibits the TAF12-dependent transactivation. Interacts with adenovirus 2 E1A; the interaction enhances the ATF7-mediated viral transactivation activity which requires the zinc-binding domains of both E1A and ATF7. Interacts with MAPK9; the interaction does not phosphorylate ATF7 but acts as a docking site for ATF7-associated partners such as JUN.

    Alternative splice isoforms for ATF7 Gene

neXtProt entry for ATF7 Gene

Post-translational modifications for ATF7 Gene

  • On EGF stimulation, phosphorylated first on Thr-53 allowing subsequent phosphorylation on Thr-51. This latter phosphorylation prevents sumoylation, increases binding to TAF12 and enhances transcriptional activity.
  • Sumoylation delays nuclear localization and inhibits transactivation activity through preventing binding to TAF12. RANBP2 appears to be the specific E3 ligase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ATF7 Gene

Domains & Families for ATF7 Gene

Gene Families for ATF7 Gene

Suggested Antigen Peptide Sequences for ATF7 Gene

Graphical View of Domain Structure for InterPro Entry

P17544

UniProtKB/Swiss-Prot:

ATF7_HUMAN :
  • Contains 1 bZIP (basic-leucine zipper) domain.
  • Belongs to the bZIP family.
  • Contains 1 C2H2-type zinc finger.
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family.
Similarity:
  • Contains 1 C2H2-type zinc finger.
genes like me logo Genes that share domains with ATF7: view

Function for ATF7 Gene

Molecular function for ATF7 Gene

UniProtKB/Swiss-Prot Function:
Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5-GTGACGT[AG][AG]-3), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family.
UniProtKB/Swiss-Prot Function:
Isoform 4 acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter.
UniProtKB/Swiss-Prot Function:
Isoform 5 acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.

Gene Ontology (GO) - Molecular Function for ATF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 10376527
GO:0008134 transcription factor binding IDA 10376527
GO:0019899 enzyme binding IPI 23382074
genes like me logo Genes that share ontologies with ATF7: view
genes like me logo Genes that share phenotypes with ATF7: view

Animal Models for ATF7 Gene

MGI Knock Outs for ATF7:

Animal Model Products

miRNA for ATF7 Gene

miRTarBase miRNAs that target ATF7
Targeted motifs for ATF7 Gene
HOMER Transcription Factor Regulatory Elements motif ATF7
  • Consensus sequence: NGRTGACGTCAY Submotif: canonical Cell Type: 3T3L1 GEO ID: GSE56872

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for ATF7 Gene

Localization for ATF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATF7 Gene

Nucleus. Nucleus, nucleoplasm. Note=Mainly nucleoplasmic. Restricted distribution to the perinuculear region. The sumoylated form locates to the nuclear periphery.
Isoform 5: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATF7 Gene COMPARTMENTS Subcellular localization image for ATF7 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ATF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 8288576
GO:0005654 nucleoplasm IEA --
GO:0005737 cytoplasm IEA --
GO:0034399 nuclear periphery IDA 17264123
genes like me logo Genes that share ontologies with ATF7: view

Pathways & Interactions for ATF7 Gene

genes like me logo Genes that share pathways with ATF7: view

Pathways by source for ATF7 Gene

Gene Ontology (GO) - Biological Process for ATF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IDA 8288576
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with ATF7: view

No data available for SIGNOR curated interactions for ATF7 Gene

Drugs & Compounds for ATF7 Gene

(3) Drugs for ATF7 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pseudoephedrine Approved Pharma Target 606
cyclic amp Experimental Pharma 0
genes like me logo Genes that share compounds with ATF7: view

Transcripts for ATF7 Gene

Unigene Clusters for ATF7 Gene

Activating transcription factor 7:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATF7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c
SP1: - - - - - - -
SP2: - - - - -
SP3: - -
SP4: -
SP5:
SP6: -

Relevant External Links for ATF7 Gene

GeneLoc Exon Structure for
ATF7
ECgene alternative splicing isoforms for
ATF7

Expression for ATF7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ATF7 Gene

Protein differential expression in normal tissues from HIPED for ATF7 Gene

This gene is overexpressed in NK cells (15.7), Fetal testis (13.4), Fetal ovary (12.3), and Testis (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ATF7 Gene



Protein tissue co-expression partners for ATF7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ATF7 Gene:

ATF7

SOURCE GeneReport for Unigene cluster for ATF7 Gene:

Hs.12286

mRNA Expression by UniProt/SwissProt for ATF7 Gene:

P17544-ATF7_HUMAN
Tissue specificity: Expressed in heart, lung and skeletal muscle. Isoform 4 is expressed in various tissues including heart, brain, placenta, lung and skeletal muscle. Highest levels in skeletal muscle. Lowest in lung and placenta.
genes like me logo Genes that share expression patterns with ATF7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ATF7 Gene

Orthologs for ATF7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ATF7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATF7 34 35
  • 99.93 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 99 (a)
OneToMany
ATF7 34
  • 94.96 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 98 (a)
OneToMany
ATF7 34
  • 94.81 (n)
mouse
(Mus musculus)
Mammalia ATF7 35
  • 97 (a)
ManyToMany
Atf7 34 16 35
  • 92.62 (n)
rat
(Rattus norvegicus)
Mammalia Atf7 34
  • 91.65 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 62 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 56 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 91 (a)
OneToMany
ATF7 34
  • 78.26 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 90 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia atf7 34
  • 73.59 (n)
Str.18007 34
zebrafish
(Danio rerio)
Actinopterygii atf7a 34 35
  • 68.57 (n)
atf7b 35
  • 61 (a)
ManyToMany
wufa97a09 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9788 34
Species where no ortholog for ATF7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATF7 Gene

ENSEMBL:
Gene Tree for ATF7 (if available)
TreeFam:
Gene Tree for ATF7 (if available)

Paralogs for ATF7 Gene

Paralogs for ATF7 Gene

(2) SIMAP similar genes for ATF7 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ATF7: view

Variants for ATF7 Gene

Sequence variations from dbSNP and Humsavar for ATF7 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10047546 -- 53,536,615(+) gggcg(C/T)ggtgg intron-variant
rs10128880 -- 53,533,999(+) CCGGC(C/T)GGGCA intron-variant
rs10467109 -- 53,577,542(+) aaacc(C/T)cgtct intron-variant
rs10655 -- 53,543,084(+) ACTAA(C/T)ACTCC intron-variant, utr-variant-3-prime
rs10696202 -- 53,613,255(+) TACTT(-/AAAAC)AAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATF7 Gene

Variant ID Type Subtype PubMed ID
esv2672386 CNV deletion 23128226
esv2673908 CNV deletion 23128226
esv2745909 CNV deletion 23290073
esv3629542 CNV loss 21293372
esv3629543 CNV loss 21293372
esv3629544 CNV loss 21293372
nsv1113484 CNV deletion 24896259
nsv1122736 CNV deletion 24896259
nsv526791 CNV gain 19592680
nsv53289 CNV insertion 16902084
nsv715 CNV deletion 18451855
nsv973988 CNV duplication 23825009
nsv975496 CNV duplication 23825009
nsv983486 CNV duplication 23825009

Variation tolerance for ATF7 Gene

Residual Variation Intolerance Score: 31.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATF7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATF7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATF7 Gene

Disorders for ATF7 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ATF7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
penicilliosis
familial atrial fibrillation
  • atrial fibrillation, familial, 1
- elite association - COSMIC cancer census association via MalaCards
Search ATF7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ATF7

Genetic Association Database (GAD)
ATF7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATF7
genes like me logo Genes that share disorders with ATF7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ATF7 Gene

Publications for ATF7 Gene

  1. A functional interaction between ATF7 and TAF12 that is modulated by TAF4. (PMID: 15735663) Hamard P.J. … Chatton B. (Oncogene 2005) 3 4 22 64
  2. Role of the ATFa/JNK2 complex in Jun activation. (PMID: 10376527) De Graeve F. … Chatton B. (Oncogene 1999) 3 4 22 64
  3. Isolation and characterization of two novel, closely related ATF cDNA clones from HeLa cells. (PMID: 1694576) Gaire M. … Kedinger C. (Nucleic Acids Res. 1990) 2 3 4 64
  4. A cytoplasmic negative regulator isoform of ATF7 impairs ATF7 and ATF2 phosphorylation and transcriptional activity. (PMID: 21858082) Diring J. … Chatton B. (PLoS ONE 2011) 3 4 64
  5. Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. (PMID: 21998595) N'Diaye A. … Haiman C.A. (PLoS Genet. 2011) 3 46 64

Products for ATF7 Gene

Sources for ATF7 Gene

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