Aliases for ATF6B Gene
External Ids for ATF6B Gene
Previous HGNC Symbols for ATF6B Gene
Previous GeneCards Identifiers for ATF6B Gene
The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
GeneCards Summary for ATF6B Gene
ATF6B (Activating Transcription Factor 6 Beta) is a Protein Coding gene. Diseases associated with ATF6B include Narcolepsy. Among its related pathways are Toll-like Receptor Signaling Pathway and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription regulatory region DNA binding. An important paralog of this gene is ATF6.
UniProtKB/Swiss-Prot for ATF6B Gene
Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5-CCAC[GA]-3 half of the ER stress response element (ERSE) (5-CCAATN(9)CCAC[GA]-3) when NF-Y is bound to ERSE.