Aliases for ATF6B Gene
External Ids for ATF6B Gene
Previous HGNC Symbols for ATF6B Gene
Previous GeneCards Identifiers for ATF6B Gene
The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
GeneCards Summary for ATF6B Gene
ATF6B (Activating Transcription Factor 6 Beta) is a Protein Coding gene. Diseases associated with ATF6B include Narcolepsy. Among its related pathways are Insulin secretion and Protein processing in endoplasmic reticulum. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription regulatory region DNA binding. An important paralog of this gene is ATF6.
UniProtKB/Swiss-Prot for ATF6B Gene
Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5-CCAC[GA]-3 half of the ER stress response element (ERSE) (5-CCAATN(9)CCAC[GA]-3) when NF-Y is bound to ERSE.