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Aliases for ATF6B Gene

Aliases for ATF6B Gene

  • Activating Transcription Factor 6 Beta 2 3 4 5
  • CAMP Response Element-Binding Protein-Related Protein 3 4
  • CAMP Responsive Element Binding Protein-Like 1 2 3
  • CAMP-Dependent Transcription Factor ATF-6 Beta 3 4
  • CAMP-Responsive Element-Binding Protein-Like 1 3 4
  • Protein G13 3 4
  • CREB-RP 3 4
  • CREBL1 3 4
  • G13 3 4
  • Creb-Related Protein 3
  • ATF6-Beta 4

External Ids for ATF6B Gene

Previous HGNC Symbols for ATF6B Gene

  • CREBL1

Previous GeneCards Identifiers for ATF6B Gene

  • GC06M032194
  • GC06M031840

Summaries for ATF6B Gene

Entrez Gene Summary for ATF6B Gene

  • The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

GeneCards Summary for ATF6B Gene

ATF6B (Activating Transcription Factor 6 Beta) is a Protein Coding gene. Diseases associated with ATF6B include narcolepsy. Among its related pathways are Insulin secretion and Myometrial Relaxation and Contraction Pathways. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription regulatory region DNA binding. An important paralog of this gene is ATF6.

UniProtKB/Swiss-Prot for ATF6B Gene

  • Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5-CCAC[GA]-3 half of the ER stress response element (ERSE) (5-CCAATN(9)CCAC[GA]-3) when NF-Y is bound to ERSE.

Gene Wiki entry for ATF6B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATF6B Gene

Genomics for ATF6B Gene

Regulatory Elements for ATF6B Gene

Promoters for ATF6B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ATF6B on UCSC Golden Path with GeneCards custom track

Genomic Location for ATF6B Gene

Chromosome:
6
Start:
32,098,176 bp from pter
End:
32,128,253 bp from pter
Size:
30,078 bases
Orientation:
Minus strand

Genomic View for ATF6B Gene

Genes around ATF6B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATF6B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATF6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for ATF6B Gene

  • Protein details for ATF6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99941-ATF6B_HUMAN
    Recommended name:
    Cyclic AMP-dependent transcription factor ATF-6 beta
    Protein Accession:
    Q99941
    Secondary Accessions:
    • B0UYX6
    • Q13269
    • Q14343
    • Q14345
    • Q5SSW7
    • Q99635
    • Q99637
    • Q9H3V9
    • Q9H3W1
    • Q9NPL0

    Protein attributes for ATF6B Gene

    Size:
    703 amino acids
    Molecular mass:
    76709 Da
    Quaternary structure:
    • Homodimer and heterodimer with ATF6-alpha. The dimer interacts with the nuclear transcription factor Y (NF-Y) trimer through direct binding to NF-Y subunit C (NF-YC).
    SequenceCaution:
    • Sequence=AAC50888.1; Type=Frameshift; Positions=600; Evidence={ECO:0000305}; Sequence=AAG14898.1; Type=Frameshift; Positions=600; Evidence={ECO:0000305};

    Alternative splice isoforms for ATF6B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATF6B Gene

Proteomics data for ATF6B Gene at MOPED

Post-translational modifications for ATF6B Gene

  • During unfolded protein response an approximative 60 kDa fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage is probably performed sequentially by site-1 and site-2 proteases.
  • N-glycosylated.
  • Ubiquitination at Lys 305
  • Glycosylation at Asn 476, Asn 505, Asn 610, Asn 627, and Asn 676
  • Modification sites at PhosphoSitePlus

Other Protein References for ATF6B Gene

Antibody Products

No data available for DME Specific Peptides for ATF6B Gene

Domains & Families for ATF6B Gene

Gene Families for ATF6B Gene

Protein Domains for ATF6B Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q99941

UniProtKB/Swiss-Prot:

ATF6B_HUMAN :
  • The basic domain functions as a nuclear localization signal.
  • Belongs to the bZIP family. ATF subfamily.
Domain:
  • The basic domain functions as a nuclear localization signal.
  • The basic leucine-zipper domain is sufficient for association with the NF-Y trimer and binding to ERSE.
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family. ATF subfamily.
genes like me logo Genes that share domains with ATF6B: view

Function for ATF6B Gene

Molecular function for ATF6B Gene

UniProtKB/Swiss-Prot Function:
Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5-CCAC[GA]-3 half of the ER stress response element (ERSE) (5-CCAATN(9)CCAC[GA]-3) when NF-Y is bound to ERSE.

Gene Ontology (GO) - Molecular Function for ATF6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12445808
GO:0044212 transcription regulatory region DNA binding IDA 11256944
genes like me logo Genes that share ontologies with ATF6B: view
genes like me logo Genes that share phenotypes with ATF6B: view

Animal Models for ATF6B Gene

MGI Knock Outs for ATF6B:

Animal Model Products

  • Taconic Biosciences Mouse Models for ATF6B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ATF6B Gene

Localization for ATF6B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATF6B Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Processed cyclic AMP-dependent transcription factor ATF-6 beta: Nucleus. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATF6B Gene COMPARTMENTS Subcellular localization image for ATF6B gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 5
golgi apparatus 4

No data available for Gene Ontology (GO) - Cellular Components for ATF6B Gene

Pathways & Interactions for ATF6B Gene

genes like me logo Genes that share pathways with ATF6B: view

Gene Ontology (GO) - Biological Process for ATF6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0036500 ATF6-mediated unfolded protein response TAS 22013210
genes like me logo Genes that share ontologies with ATF6B: view

No data available for SIGNOR curated interactions for ATF6B Gene

Drugs & Compounds for ATF6B Gene

(1) Drugs for ATF6B Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ATF6B: view

Transcripts for ATF6B Gene

Unigene Clusters for ATF6B Gene

Activating transcription factor 6 beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATF6B Gene

No ASD Table

Relevant External Links for ATF6B Gene

GeneLoc Exon Structure for
ATF6B
ECgene alternative splicing isoforms for
ATF6B

Expression for ATF6B Gene

mRNA expression in normal human tissues for ATF6B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ATF6B Gene

This gene is overexpressed in Serum (65.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATF6B Gene



SOURCE GeneReport for Unigene cluster for ATF6B Gene Hs.42853

mRNA Expression by UniProt/SwissProt for ATF6B Gene

Q99941-ATF6B_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with ATF6B: view

Protein tissue co-expression partners for ATF6B Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ATF6B Gene

Orthologs for ATF6B Gene

This gene was present in the common ancestor of animals.

Orthologs for ATF6B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ATF6B 35
  • 88.63 (n)
  • 87.5 (a)
ATF6B 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATF6B 35
  • 87.78 (n)
  • 89.15 (a)
ATF6B 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atf6b 35
  • 86.03 (n)
  • 88.13 (a)
Atf6b 16
Atf6b 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ATF6B 35
  • 98.86 (n)
  • 98.72 (a)
ATF6B 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atf6b 35
  • 85.98 (n)
  • 87.27 (a)
oppossum
(Monodelphis domestica)
Mammalia ATF6B 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 60 (a)
OneToMany
-- 36
  • 69 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia ATF6B 36
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atf6b 35
  • 52.93 (n)
  • 52.73 (a)
Str.19591 35
zebrafish
(Danio rerio)
Actinopterygii atf6b 35
  • 55.51 (n)
  • 48.39 (a)
ATF6B 36
  • 36 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Atf6 36
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
OneToMany
Species with no ortholog for ATF6B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATF6B Gene

ENSEMBL:
Gene Tree for ATF6B (if available)
TreeFam:
Gene Tree for ATF6B (if available)

Paralogs for ATF6B Gene

Paralogs for ATF6B Gene

(3) SIMAP similar genes for ATF6B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ATF6B: view

Variants for ATF6B Gene

Sequence variations from dbSNP and Humsavar for ATF6B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs169495 -- 32,125,070(-) tgggc(A/G)gatca intron-variant
rs8111 -- 32,115,398(-) GGTGG(A/G)ACAAG utr-variant-3-prime
rs8283 -- 32,115,523(-) AGTCC(C/T)GGCTT utr-variant-3-prime
rs204888 -- 32,121,365(-) TGCCT(A/C)ATCCT intron-variant
rs204889 -- 32,118,315(-) tcgcc(C/T)ggccT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATF6B Gene

Variant ID Type Subtype PubMed ID
dgv1928e1 CNV Complex 17122850
nsv428141 CNV Gain+Loss 18775914
dgv1929e1 CNV Complex 17122850
nsv830629 CNV Loss 17160897
nsv884701 CNV Gain 21882294
nsv884702 CNV Loss 21882294

Variation tolerance for ATF6B Gene

Residual Variation Intolerance Score: 50.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.06; 37.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATF6B Gene

HapMap Linkage Disequilibrium report
ATF6B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATF6B Gene

Disorders for ATF6B Gene

MalaCards: The human disease database

(1) MalaCards diseases for ATF6B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
narcolepsy
  • narcolepsy, without cataplexy
- elite association - COSMIC cancer census association via MalaCards
Search ATF6B in MalaCards View complete list of genes associated with diseases

Relevant External Links for ATF6B

Genetic Association Database (GAD)
ATF6B
Human Genome Epidemiology (HuGE) Navigator
ATF6B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATF6B
genes like me logo Genes that share disorders with ATF6B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ATF6B Gene

Publications for ATF6B Gene

  1. Identification of the G13 (cAMP-response-element-binding protein- related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response. (PMID: 11256944) Haze K. … Mori K. (Biochem. J. 2001) 2 3 4 23 67
  2. Opposing roles for ATF6alpha and ATF6beta in endoplasmic reticulum stress response gene induction. (PMID: 14973138) Thuerauf D.J. … Glembotski C.C. (J. Biol. Chem. 2004) 2 3 23
  3. A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6. (PMID: 12782636) Okada T. … Mori K. (J. Biol. Chem. 2003) 3 23
  4. Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response. (PMID: 11158310) Yoshida H. … Mori K. (Mol. Cell. Biol. 2001) 3 23
  5. The gene G13 in the class III region of the human MHC encodes a potential DNA-binding protein. (PMID: 8870652) Khanna A. … Campbell R.D. (Biochem. J. 1996) 3 23

Products for ATF6B Gene

Sources for ATF6B Gene

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