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ATF6B Gene

protein-coding   GIFtS: 54
GCID: GC06M032065

Activating Transcription Factor 6 Beta

(Previous name: cAMP responsive element binding protein-like 1)
(Previous symbol: CREBL1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Activating Transcription Factor 6 Beta1 2 3     CAMP-Responsive Element-Binding Protein-Like 12 3
CREBL11 2 3 5     CREB-RP2
CAMP Responsive Element Binding Protein-Like 11 2     Creb-Related Protein2
Protein G132 3     Cyclic AMP-Dependent Transcription Factor ATF-6 Beta2
G132 3     ATF6-beta3
CAMP Response Element-Binding Protein-Related Protein2 3     Creb-rp3
CAMP-Dependent Transcription Factor ATF-6 Beta2 3     

External Ids:    HGNC: 23491   Entrez Gene: 13882   Ensembl: ENSG000002136767   OMIM: 6009845   UniProtKB: Q999413   

Export aliases for ATF6B gene to outside databases

Previous GC identifers: GC06M032194 GC06M031840


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ATF6B Gene:
The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during
ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress
response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is
normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic
domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Oct 2008)

GeneCards Summary for ATF6B Gene:
ATF6B (activating transcription factor 6 beta) is a protein-coding gene. Diseases associated with ATF6B include narcolepsy, and hepatitis c virus. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ATF6.

UniProtKB/Swiss-Prot: ATF6B_HUMAN, Q99941
Function: Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target
genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE)
(5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE

Gene Wiki entry for ATF6B (CREBL1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  NT_113891.3  NT_167245.2  NT_167247.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ATF6B gene promoter:
         SRF   RFX1   SRF (504 AA)   CUTL1   AREB6   POU2F1   POU2F1b   POU2F1a   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATF6B promoter sequence
   Search Chromatin IP Primers for ATF6B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATF6B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

ATF6B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATF6B gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M032065:  view genomic region     (about GC identifiers)

Start:
32,065,953 bp from pter      End:
32,096,030 bp from pter
Size:
30,078 bases      Orientation:
minus strand

3 alternative locations:
Chr6-,NT_113891.2 3,553,707-3,566,677      Chr6-,NT_167245 3,362,219-3,375,189      Chr6-,NT_167247 3,462,873-3,475,845     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ATF6B_HUMAN, Q99941 (See protein sequence)
Recommended Name: Cyclic AMP-dependent transcription factor ATF-6 beta  
Size: 703 amino acids; 76709 Da
Subunit: Homodimer and heterodimer with ATF6-alpha. The dimer interacts with the nuclear transcription factor Y
(NF-Y) trimer through direct binding to NF-Y subunit C (NF-YC)
Sequence caution: Sequence=AAC50888.1; Type=Frameshift; Positions=600; Sequence=AAG14898.1; Type=Frameshift;
Positions=600;
Secondary accessions: B0UYX6 Q13269 Q14343 Q14345 Q5SSW7 Q99635 Q99637 Q9H3V9 Q9H3W1 Q9NPL0
Alternative splicing: 2 isoforms:  Q99941-1   Q99941-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ATF6B: NX_Q99941

Explore proteomics data for ATF6B at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • During unfolded protein response an approximative 60 kDa fragment containing the cytoplasmic transcription factor
    domain is released by proteolysis. The cleavage is probably performed sequentially by site-1 and site-2 proteases1
  • Ubiquitination2 at Lys305
  • Glycosylation2 at Asn476, Asn505, Asn610, Asn627, Asn676
  • Modification sites at PhosphoSitePlus

  • See ATF6B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001129625.1  NP_004372.3  

    ENSEMBL proteins: 
     ENSP00000364349   ENSP00000364347   ENSP00000393419  

    ATF6B Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Browse Proteins at Cloud-Clone Corp.

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    LSBio Antibodies in human, mouse, rat for ATF6B

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bZIP: basic leucine zipper proteins

    1 InterPro protein domain:
     IPR004827 bZIP

    Graphical View of Domain Structure for InterPro Entry Q99941

    ProtoNet protein and cluster: Q99941

    1 Blocks protein domain: IPB011616 bZIP transcription factor

    UniProtKB/Swiss-Prot: ATF6B_HUMAN, Q99941
    Domain: The basic domain functions as a nuclear localization signal
    Domain: The basic leucine-zipper domain is sufficient for association with the NF-Y trimer and binding to ERSE
    Similarity: Belongs to the bZIP family. ATF subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    ATF6B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATF6B_HUMAN, Q99941
    Function: Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target
    genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE)
    (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI12445808
    GO:0043565sequence-specific DNA binding IEA--
         
    ATF6B for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ATF6B:
     Increased cilium length after   Increased gamma-H2AX phosphory 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Atf6b):
     cellular  mortality/aging 

    ATF6B for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ATF6B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ATF6B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ATF6B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ATF6B

    miRNA
    Products:
        
    miRTarBase miRNAs that target ATF6B:
    hsa-mir-197-3p (MIRT004191)

    Block miRNA regulation of human, mouse, rat ATF6B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ATF6B (see all 25):
    hsa-miR-623 hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-1224-3p hsa-miR-1260b hsa-miR-302e hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidATF6B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ATF6B
    Predesigned siRNA for gene silencing in human, mouse, rat ATF6B

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): ATF6B (NM_001136153)
    Sino Biological Human cDNA Clone for ATF6B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATF6B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATF6B

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATF6B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ATF6B_HUMAN, Q99941: Endoplasmic reticulum membrane; Single-pass type II membrane protein
    ATF6B_HUMAN, Q99941: Processed cyclic AMP-dependent transcription factor ATF-6 beta: Nucleus. Note=Under ER
    stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    nucleus5

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA8870652
    GO:0005634nucleus IEA--
    GO:0005730nucleolus ----
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005925focal adhesion ----

    ATF6B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ATF6B About   (see all 13)  
    See pathways by source

    SuperPathContained pathways About
    1Amphetamine addiction
    Cocaine addiction0.44
    Amphetamine addiction0.44
    2Insulin secretion
    Insulin secretion0.36
    Thyroid hormone synthesis0.36
    3Myometrial Relaxation and Contraction Pathways
    Myometrial Relaxation and Contraction Pathways0.43
    4Circadian entrainment
    Dopaminergic synapse0.37
    5E2F mediated regulation of DNA replication
    G1 to S cell cycle control0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for ATF6B
        Myometrial Relaxation and Contraction Pathways
    G1 to S cell cycle control



    Selected Kegg Pathways  (Kegg details for ATF6B) (see all 13):
        Protein processing in endoplasmic reticulum
    PI3K-Akt signaling pathway
    Adrenergic signaling in cardiomyocytes
    TNF signaling pathway
    Dopaminergic synapse


    ATF6B for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ATF6B: 
              Unfolded Protein Response in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ATF6B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for ATF6B (Q999411, 3 ENSP000003643494) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATF6P188503, ENSP000003569194I2D: score=3 STRING: ENSP00000356919
    NFYCQ139523, ENSP000003966204I2D: score=2 STRING: ENSP00000396620
    MBTPS2O434623, ENSP000003687984I2D: score=1 STRING: ENSP00000368798
    PHOX2AO148133, ENSP000002982314I2D: score=1 STRING: ENSP00000298231
    MBTPS1Q147033, ENSP000003442234I2D: score=2 STRING: ENSP00000344223
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006986response to unfolded protein IEA--
    GO:0007165signal transduction TAS8586413

    ATF6B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ATF6B

    1 Novoseek inferred chemical compound relationship for ATF6B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 55.5 3 8870652 (2), 11158310 (1)



    ATF6B for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ATF6B gene (2 alternative transcripts): 
    NM_001136153.1  NM_004381.4  

    Unigene Cluster for ATF6B:

    Activating transcription factor 6 beta
    Hs.42853  [show with all ESTs]
    Unigene Representative Sequence: NM_004381
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000494022 ENST00000375203(uc003nzm.1 uc003nzn.3 uc003nzp.1)
    ENST00000375201(uc003nzo.3) ENST00000453203 ENST00000475705 ENST00000492342
    ENST00000495579(uc011dpg.2 uc011dph.2) ENST00000485314 ENST00000468502

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ATF6B (see all 25):
    hsa-miR-623 hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-1224-3p hsa-miR-1260b hsa-miR-302e hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidATF6B 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): ATF6B (NM_001136153)
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      QuantiFast Probe-based Assays in human, mouse, rat ATF6B

    Additional mRNA sequence: 

    AK000928.1 BC008394.1 BC077075.1 BT007042.1 U31903.1 X98054.1 

    12 DOTS entries:

    DT.100746884  DT.213508  DT.99982837  DT.100727968  DT.100746886  DT.91767311  DT.91767318  DT.95256648 
    DT.99951243  DT.91767313  DT.95108806  DT.99959564 

    Selected AceView cDNA sequences (see all 262):

    BM712719 BF245619 BF081859 BU540502 BG741952 BM926447 BM723024 CB243599 
    AA921976 BC033740 BC077075 BM691419 U52701 BU681983 BI909316 CD365060 
    CB853478 AA713482 NM_019105 Y17868 BP359599 AL520344 BM904001 BI755715 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ATF6B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACACCAGGG
    ATF6B Expression
    About this image


    ATF6B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Kidney (Urinary System)
             Metanephros
    ATF6B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ATF6B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.42853

    UniProtKB/Swiss-Prot: ATF6B_HUMAN, Q99941
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ATF6B: 
              Unfolded Protein Response in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ATF6B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ATF6B
    QuantiTect SYBR Green Assays in human, mouse, rat ATF6B
    QuantiFast Probe-based Assays in human, mouse, rat ATF6B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATF6B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ATF6B gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atf6b1 , 5 activating transcription factor 6 beta1, 5 86.03(n)1
    88.13(a)1
      17 (18.22 cM)5
    129151  NM_017406.41  NP_059102.21 
     346471465 
    lizard
    (Anolis carolinensis)
    Reptilia ATF6B6
    activating transcription factor 6 beta
    43(a)
    1 ↔ 1
    2(194779151-194808567)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.195912 Transcribed sequence with weak similarity to protein more 74.75(n)    AL878690.2 
    zebrafish
    (Danio rerio)
    Actinopterygii atf6b1 activating transcription factor 6 beta 55.51(n)
    48.39(a)
      777612  NM_001077720.1  NP_001071188.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Atf66
    Atf6
    18(a)
    1 → many
    2R(1032238-1042261)


    ENSEMBL Gene Tree for ATF6B (if available)
    TreeFam Gene Tree for ATF6B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ATF6B gene
    ATF62  
    3 SIMAP similar genes for ATF6B using alignment to 4 protein entries:     ATF6B_HUMAN (see all proteins):
    C8orf17    LZLP    ATF6

    ATF6B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ATF6B (see all 285)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1917475871,2
    --32082635(+) ACCCCC/TTCTTC 2 -- ds50010--------
    rs624027181,2
    C--32082661(+) TCCTGG/AGCTCT 2 -- ds50013Minor allele frequency- A:0.07NA WA 240
    rs560874681,2
    C--32082888(+) TGCAGA/GGGTGG 2 -- ds50010--------
    rs1839934961,2
    C--32083031(+) GGAAGA/GCAGCC 2 -- ds50010--------
    rs81111,2
    C,F,H--32083175(-) GGTGGG/AACAAG 2 -- ut3122Minor allele frequency- A:0.20EA MN NS NA 4100
    rs1888817571,2
    --32083211(+) GCCATA/GACACT 2 -- ut310--------
    rs82831,2
    C,F,A,H--32083300(-) AGTCCT/CGGCTT 2 -- ut3135Minor allele frequency- C:0.29EA NA MN NS WA CSA 4795
    rs2012660721,2
    --32083481(+) ACCCCC/TTCCCC 2 -- ut310--------
    rs1999681501,2
    C--32083488(+) CCCCCA/C/TGTTCT 4 -- ut310--------
    rs801877251,2
    C,F--32083536(+) GTAGAG/TGGGCT 4 I L mis12Minor allele frequency- T:0.00WA NA 4552

    HapMap Linkage Disequilibrium report for ATF6B (32065953 - 32096030 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ATF6B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv884702CNV Loss21882294
    nsv830629CNV Loss17160897
    nsv884701CNV Gain21882294
    nsv428141CNV Gain+Loss18775914
    dgv1928e1CNV Complex17122850
    dgv1929e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ATF6B
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600984    OMIM disorders: --

    9 diseases for ATF6B:    
    About MalaCards
    narcolepsy    hepatitis c virus    systemic lupus erythematosus    hepatitis c
    lupus erythematosus    hepatitis    hepatitis b    cerebritis
    thyroiditis


    ATF6B for disorders           About GeneDecksing

    Genetic Association Database (GAD): ATF6B
    Human Genome Epidemiology (HuGE) Navigator: ATF6B (6 documents)

    Export disorders for ATF6B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ATF6B gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with ATF6B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of the G13 (cAMP-response-element-binding protein- related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response. (PubMed id 11256944)1, 2, 3, 9 Haze K....Mori K. (Biochem. J. 2001)
    2. The gene G13 in the class III region of the human MHC encodes a potential DNA-binding protein. (PubMed id 8870652)1, 2, 9 Khanna A. and Campbell R.D. (Biochem. J. 1996)
    3. Opposing roles for ATF6alpha and ATF6beta in endoplasmic reticulum stress response gene induction. (PubMed id 14973138)1, 3, 9 Thuerauf D.J....Glembotski C.C. (J. Biol. Chem. 2004)
    4. Alternate promoters and alternate splicing of human tenascin-X, a gene with 5' and 3' ends buried in other genes. (PubMed id 8923003)1, 2, 9 Speek M.... Miller W.L. (Hum. Mol. Genet. 1996)
    5. A novel Creb family gene telomeric of HLA-DRA in the HLA complex. (PubMed id 8586413)1, 2, 9 Min J....Chaplin D.D. (Genomics 1995)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (PLoS Genet. 2009)
    8. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    9. Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PubMed id 14656967)1, 2 Xie T.... Hood L. (Genome Res. 2003)
    10. Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response. (PubMed id 11158310)1, 9 Yoshida H....Mori K. (Mol. Cell. Biol. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1388 HGNC: 2349 AceView: CREBL1andTNXB Ensembl:ENSG00000213676 euGenes: HUgn1388
    ECgene: ATF6B Kegg: 1388 H-InvDB: ATF6B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ATF6B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ATF6B gene:
    Search GeneIP for patents involving ATF6B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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