Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ATF6 Gene

protein-coding   GIFtS: 63
GCID: GC01P161736

Activating Transcription Factor 6

  See ATF6-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Activating Transcription Factor 61 2
Activating Transcription Factor 6 Alpha1 3
CAMP-Dependent Transcription Factor ATF-6 Alpha2 3
ATF6A2
Cyclic AMP-Dependent Transcription Factor ATF-6 Alpha2
ATF6-alpha3

External Ids:    HGNC: 7911   Entrez Gene: 229262   Ensembl: ENSG000001182177   OMIM: 6055375   UniProtKB: P188503   

Export aliases for ATF6 gene to outside databases

Previous GC identifers: GC01P159370 GC01P157386 GC01P158432 GC01P158923 GC01P158467 GC01P160002 GC01P132981


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ATF6 Gene:
This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR)
during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that
it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress
sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor
via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER
chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous
carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with
diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol
levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. (provided by RefSeq,
Aug 2011)

GeneCards Summary for ATF6 Gene:
ATF6 (activating transcription factor 6) is a protein-coding gene. Diseases associated with ATF6 include wolfram syndrome, and cystic fibrosis. GO annotations related to this gene include transcription coactivator activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ATF6B.

UniProtKB/Swiss-Prot: ATF6A_HUMAN, P18850
Function: Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein
response target genes. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE)
(5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to
ERSE. Could also be involved in activation of transcription by the serum response factor

Gene Wiki entry for ATF6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ATF6 gene promoter:
         USF1   Tal-1   AML1a   E47   CREB   deltaCREB   USF-1   c-Myb   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATF6 promoter sequence
   Search Chromatin IP Primers for ATF6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATF6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22-q23   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q22-q23

ATF6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATF6 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P161736:  view genomic region     (about GC identifiers)

Start:
161,736,084 bp from pter      End:
161,933,860 bp from pter
Size:
197,777 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ATF6A_HUMAN, P18850 (See protein sequence)
Recommended Name: Cyclic AMP-dependent transcription factor ATF-6 alpha  
Size: 670 amino acids; 74585 Da
Subunit: Homodimer and heterodimer with ATF6-beta. The dimer interacts with the nuclear transcription factor Y
(NF-Y) trimer through direct binding to NF-Y subunit C (NF-YC). Interacts also with the transcription factors
GTF2I, YY1 and SRF. Interacts (via lumenal domain) with THBS1 (By similarity). Interacts with THBS4 (via EGF-like
3; calcium-binding domain) which facilitates its processing, activation and nuclear translocation
Secondary accessions: O15139 Q5VW62 Q6IPB5 Q9UEC9

Explore the universe of human proteins at neXtProt for ATF6: NX_P18850

Explore proteomics data for ATF6 at MOPED

Post-translational modifications: 

  • During unfolded protein response an approximative 50 kDa fragment containing the cytoplasmic transcription factor
    domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases1
  • N-glycosylated. The glycosylation status may serve as a sensor for ER homeostasis, resulting in ATF6 activation to
    trigger the unfolded protein response (UPR)1
  • Phosphorylated in vitro by MAPK14/P38MAPK1
  • Ubiquitination2 at Lys424, Lys436
  • Glycosylation2 at Asn472, Asn584, Asn643
  • Modification sites at PhosphoSitePlus

  • See ATF6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_031374.2  
    ENSEMBL proteins: 
     ENSP00000356919  
    Reactome Protein details: P18850

    ATF6 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ATF6
    GenScript Custom Purified and Recombinant Proteins Services for ATF6
    Novus Biologicals ATF6 Proteins
    Novus Biologicals ATF6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ATF6

     
    Search eBioscience for Proteins for ATF6 

     
    antibodies-online proteins for ATF6 (6 products) 

     
    antibodies-online peptides for ATF6

    ATF6 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ATF6
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ATF6
    OriGene Custom Antibody Services for ATF6
    Novus Biologicals ATF6 Antibodies
    Abcam antibodies for ATF6
    Cloud-Clone Corp. Antibodies for ATF6
    ThermoFisher Antibodies for ATF6
    antibodies-online antibodies for ATF6 (96 products) 

    ATF6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ATF6
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ATF6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ATF6
    Cloud-Clone Corp. CLIAs for ATF6
    Search eBioscience for ELISAs for ATF6 
    antibodies-online kits for ATF6 (21 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    bZIP: basic leucine zipper proteins

    1 InterPro protein domain:
     IPR004827 bZIP

    Graphical View of Domain Structure for InterPro Entry P18850

    ProtoNet protein and cluster: P18850

    1 Blocks protein domain: IPB011616 bZIP transcription factor

    UniProtKB/Swiss-Prot: ATF6A_HUMAN, P18850
    Domain: The basic domain functions as a nuclear localization signal
    Domain: The basic leucine-zipper domain is sufficient for association with the NF-Y trimer and binding to ERSE
    Similarity: Belongs to the bZIP family. ATF subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    Find genes that share domains with ATF6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATF6A_HUMAN, P18850
    Function: Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein
    response target genes. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE)
    (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to
    ERSE. Could also be involved in activation of transcription by the serum response factor

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003713transcription coactivator activity TAS10866666
    GO:0005515protein binding IPI16469704
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with ATF6           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ATF6:
     Cell cycle / mitosis defect  Decreased circadian period len 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Atf6):
     cellular  homeostasis/metabolism  liver/biliary system  mortality/aging  no phenotypic analysis 

    Find genes that share phenotypes with ATF6           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Atf6tm1.1Rjk for ATF6

       genOway: Develop your customized and physiologically relevant rodent model for ATF6

    miRNA
    Products:
        
    miRTarBase miRNAs that target ATF6:
    hsa-mir-191-5p (MIRT045796), hsa-mir-503-5p (MIRT000650), hsa-mir-335-5p (MIRT019158), hsa-mir-424-5p (MIRT000658)

    Block miRNA regulation of human, mouse, rat ATF6 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate ATF6:
    hsa-miR-141 hsa-miR-200a hsa-miR-1825
    SwitchGear 3'UTR luciferase reporter plasmidATF6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ATF6
    Predesigned siRNA for gene silencing in human, mouse, rat ATF6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ATF6

    Clone
    Products:
         
    OriGene clones in human, mouse for ATF6 (see all 7)
    OriGene ORF clones in mouse, rat for ATF6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ATF6 (NM_001136153)
    Sino Biological Human cDNA Clone for ATF6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATF6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATF6
    Addgene plasmids for ATF6 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ATF6
    Browse ESI BIO Cell Lines and PureStem Progenitors for ATF6 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATF6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ATF6A_HUMAN, P18850: Endoplasmic reticulum membrane; Single-pass type II membrane protein
    ATF6A_HUMAN, P18850: Processed cyclic AMP-dependent transcription factor ATF-6 alpha: Nucleus. Note=Under ER
    stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. THBS4 promotes its nuclear
    shuttling
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    nucleus5
    golgi apparatus4
    cytosol1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005634nucleus TAS10564271
    GO:0005635nuclear envelope TAS10866666
    GO:0005654nucleoplasm TAS--
    GO:0005789endoplasmic reticulum membrane TAS--

    Find genes that share ontologies with ATF6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ATF6 About   (see all 16)  
    See pathways by source

    SuperPathContained pathways About
    1Alzheimer's disease
    Alzheimers Disease0.44
    Alzheimer's disease0.44
    2Unfolded Protein Response
    Unfolded Protein Response0.61
    Activation of Chaperone Genes by ATF6-alpha0.00
    Activation of Chaperones by ATF6-alpha0.00
    3PERK regulated gene expression
    PERK regulated gene expression0.90
    Activation of Genes by ATF40.90
    4ERK Signaling
    MAPK Signaling0.58
    ILK Signaling0.49
    5TWEAK Pathway
    TNF Signaling0.55


    Find genes that share SuperPaths with ATF6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ATF6 (see all 10)
        MAPK Signaling
    PI3K Signaling in B-Lymphocyte
    Signaling Involved in Cardiac Hypertrophy
    TNF Signaling
    iNOS Signaling

    3 BioSystems Pathways for ATF6
        SREBP signalling
    Alzheimers Disease
    Signaling mediated by p38-alpha and p38-beta


    3 Reactome Pathways for ATF6
        ATF6-alpha activates chaperones
    ATF6-alpha activates chaperone genes
    ATF4 activates genes


    2 Kegg Pathways  (Kegg details for ATF6):
        Protein processing in endoplasmic reticulum
    Alzheimer's disease

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ATF6: 
              Unfolded Protein Response in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ATF6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ATF6 (P188501, 2, 3 ENSP000003569194) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREB3L3Q68CJ91, 3, ENSP000000784454EBI-852157,EBI-852194 I2D: score=2 STRING: ENSP00000078445
    ATF6BQ999413, ENSP000003643494I2D: score=3 STRING: ENSP00000364349
    ENSG00000168468Q999413I2D: score=3 
    ENSG00000228628Q999413I2D: score=3 
    ENSG00000234539Q999413I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS10564271
    GO:0006457protein folding TAS10564271
    GO:0006950response to stress TAS10866666

    Find genes that share ontologies with ATF6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ATF6 (ATF6A)

    8 Novoseek inferred chemical compound relationships for ATF6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tunicamycin 76.4 10 17101776 (2), 15845366 (1), 18022401 (1), 14973138 (1) (see all 7)
    thapsigargin 68 21 10866666 (4), 17307147 (2), 15845366 (1), 18022401 (1) (see all 8)
    sterol 41.5 5 14765107 (1), 18635952 (1), 12782636 (1), 16236796 (1)
    leucine 32.8 6 20219975 (1), 16725346 (1), 9837962 (1), 10866666 (1) (see all 6)
    dithiothreitol 31.4 1 17101776 (1)
    inositol 30.1 7 17349291 (1), 17178827 (1), 16205645 (1), 15799970 (1)
    glucose 9.32 17 17440018 (5), 17130669 (4), 14765107 (2), 20165829 (1)
    calcium 0 4 17167033 (1), 10866666 (1)



    Find genes that share compounds with ATF6           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ATF6 gene: 
    NM_007348.3  

    Unigene Cluster for ATF6:

    Activating transcription factor 6
    Hs.492740  [show with all ESTs]
    Unigene Representative Sequence: NM_007348
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367942(uc001gbq.2 uc001gbs.3) ENST00000476437
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ATF6 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate ATF6:
    hsa-miR-141 hsa-miR-200a hsa-miR-1825
    SwitchGear 3'UTR luciferase reporter plasmidATF6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ATF6
    Predesigned siRNA for gene silencing in human, mouse, rat ATF6
    Clone
    Products:
         
    OriGene clones in human, mouse for ATF6 (see all 7)
    OriGene ORF clones in mouse, rat for ATF6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ATF6 (NM_001136153)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATF6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATF6
    Addgene plasmids for ATF6 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ATF6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ATF6
      QuantiTect SYBR Green Assays in human, mouse, rat ATF6
      QuantiFast Probe-based Assays in human, mouse, rat ATF6

    Additional mRNA sequence: 

    AB015856.1 AB208929.1 AF005887.1 AF088035.1 AK025316.1 AK290498.1 BC014969.1 BC071997.1 
    BX538263.1 

    12 DOTS entries:

    DT.455847  DT.210704  DT.121437874  DT.121437859  DT.121437888  DT.408085  DT.421452  DT.92031898 
    DT.95375290  DT.100642555  DT.40310948  DT.95124201 

    Selected AceView cDNA sequences (see all 298):

    BX098288 AI357343 BP373969 AW024553 BF002812 AA485943 BP342037 AI803884 
    BM993826 AI985352 AI358137 AI871991 BM721376 CN479360 AI357345 W87752 
    AI800956 BQ218179 BP358704 BF221905 AI655874 CB141899 AA974121 BM548776 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ATF6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ATF6 Expression
    About this image


    ATF6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Eye (Sensory Organs)
             Lens
     
     Esophagus (Gastrointestinal Tract)
    ATF6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ATF6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.492740

    UniProtKB/Swiss-Prot: ATF6A_HUMAN, P18850
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ATF6: 
              Unfolded Protein Response in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ATF6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ATF6
    QuantiTect SYBR Green Assays in human, mouse, rat ATF6
    QuantiFast Probe-based Assays in human, mouse, rat ATF6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATF6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for ATF6 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atf61 , 5 activating transcription factor 61, 5 84.91(n)1
    86.13(a)1
      1 (76.96 cM)5
    2266411  NM_001081304.11  NP_001074773.11 
     1707046745 
    chicken
    (Gallus gallus)
    Aves ATF61 activating transcription factor 6 68.08(n)
    64.58(a)
      424365  XM_422208.4  XP_422208.3 
    lizard
    (Anolis carolinensis)
    Reptilia ATF66
    activating transcription factor 6
    55(a)
    1 ↔ 1
    4(71076272-71132549)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia atf61 activating transcription factor 6 62.06(n)
    57.39(a)
      100498199  XM_002933780.2  XP_002933826.2 
    zebrafish
    (Danio rerio)
    Actinopterygii atf61 activating transcription factor 6 54.69(n)
    47.42(a)
      558071  NM_001110519.1  NP_001103989.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Atf66
    Atf6
    19(a)
    1 → many
    2R(1032238-1042261)


    ENSEMBL Gene Tree for ATF6 (if available)
    TreeFam Gene Tree for ATF6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ATF6 gene
    ATF6B2  
    1 SIMAP similar gene for ATF6 using alignment to 1 protein entry:     ATF6A_HUMAN:
    ATF6B

    Find genes that share paralogs with ATF6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ATF6 (see all 3468)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1134918551,2
    C--132989131(+) TATGT-/ACACAC
            
    ACACA
    1 -- int11Minor allele frequency- ACACAC:0.50CSA 2
    rs57782341,2
    C--132991330(+) AATAA-/TTAA  
            
    GTAAT
    1 -- int10--------
    rs1403763131,2
    C--133005532(+) TGTCT-/CAACAACA 1 -- int10--------
    rs721578431,2
    C--133005785(+) TTATA-/TG    
       
    /TGTG
    TGTGT
    1 -- int10--------
    rs346974171,2
    C--133019401(+) CTGCC-/TTTTTT 1 -- int10--------
    rs2017536791,2
    C--133022585(+) TTGTC-/TCTT  
      TTTTTT
    CTTTT
    1 -- int10--------
    rs667438821,2
    C--133027012(+) TGCTT-/TGTGTGT 1 -- int10--------
    rs127304081,2
    A--133027091(+) TTTTCC/TTTTTT 1 -- int1 trp30--------
    rs715814381,2
    C--133065954(+) ACACA-/CA/   
      CACACA
    CACAC
    1 -- int11NA 2
    rs30835431,2
    C--133140152(+) AGTTT-/TTCATT
            
    AAGTT
    1 -- cds16Minor allele frequency- TTCATT:0.38EU EA NA MN 432

    HapMap Linkage Disequilibrium report for ATF6 (161736084 - 161933860 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ATF6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv269148CNV Insertion20981092
    nsv3276CNV Insertion18451855
    nsv428257CNV Loss18775914
    nsv831747CNV Loss17160897
    nsv470744CNV Gain18288195
    nsv464206CNV Gain19166990
    nsv464184CNV Gain19166990
    esv33393CNV Gain+Loss17666407

    Human Gene Mutation Database (HGMD): ATF6
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ATF6
    DNA2.0 Custom Variant and Variant Library Synthesis for ATF6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605537    OMIM disorders: --

    2 diseases for ATF6:    
    About MalaCards
    wolfram syndrome    cystic fibrosis


    Find genes that share disorders with ATF6           About GenesLikeMe

    2 Novoseek inferred disease relationships for ATF6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ischemia 0 7 19622751 (3)
    hepatocellular carcinoma 0 2 12713871 (1), 16364319 (1)

    Genetic Association Database (GAD): ATF6
    Human Genome Epidemiology (HuGE) Navigator: ATF6 (11 documents)

    Export disorders for ATF6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ATF6 gene, integrated from 10 sources (see all 199):
    (articles sorted by number of sources associating them with ATF6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Interaction of ATF6 and serum response factor. (PubMed id 9271374)1, 2, 3, 9 Zhu C.... Prywes R. (Mol. Cell. Biol. 1997)
    2. Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins; involvement of basic-leucine zipper transcription factors. (PubMed id 9837962)1, 2, 3, 9 Yoshida H.... Mori K. (J. Biol. Chem. 1998)
    3. Activating transcription factor 6 polymorphisms and haplotypes are associated with impaired glucose homeostasis and type 2 diabetes in Dutch Caucasians. (PubMed id 17440018)1, 4, 9 Meex S.J....de Bruin T.W. (J. Clin. Endocrinol. Metab. 2007)
    4. Association of amino acid variants in the activating transcription factor 6 gene (ATF6) on 1q21-q23 with type 2 diabetes in Pima Indians. (PubMed id 16505252)1, 4, 9 Thameem F....Prochazka M. (Diabetes 2006)
    5. Identification of the G13 (cAMP-response-element-binding protein- related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response. (PubMed id 11256944)1, 3, 9 Haze K....Mori K. (Biochem. J. 2001)
    6. Activating transcription factor 6 (ATF6) sequence polymorphisms in type 2 diabetes and pre-diabetic traits. (PubMed id 17327457)1, 4, 9 Chu W.S....Elbein S.C. (Diabetes 2007)
    7. The ATF6-Met[67]Val substitution is associated with increased plasma cholesterol levels. (PubMed id 19667116)1, 4, 9 Meex S.J....Glembotski C.C. (Arterioscler. Thromb. Vasc. Biol. 2009)
    8. Underglycosylation of ATF6 as a novel sensing mechanism for activation of the unfolded protein response. (PubMed id 14699159)1, 2, 9 Hong M....Lee A.S. (J. Biol. Chem. 2004)
    9. Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response. (PubMed id 11158310)1, 2, 9 Yoshida H....Mori K. (Mol. Cell. Biol. 2001)
    10. The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis. (PubMed id 11483355)1, 2, 9 Hai T. and Hartman M.G. (Gene 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 22926 HGNC: 791 AceView: ATF6 Ensembl:ENSG00000118217 euGenes: HUgn22926
    ECgene: ATF6 Kegg: 22926 H-InvDB: ATF6

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ATF6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ATF6 gene:
    Search GeneIP for patents involving ATF6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of ATF6
     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ATF6   OriGene RNAi products in human, mouse, rat for ATF6  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ATF6  
     OriGene qSTAR qPCR primer pairs in human, mouse for ATF6   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ATF6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ATF6   OriGene Custom Protein Services for ATF6  

     
     
     Block miRNA regulation of human, mouse, rat ATF6 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ATF6
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATF6 Predesigned siRNA for gene silencing in human, mouse, rat ATF6
     QuantiFast Probe-based Assays in human, mouse, rat ATF6 QuantiTect SYBR Green Assays in human, mouse, rat ATF6
     PCR Arrays including human, mouse, rat ATF6 Search Chromatin IP Primers for ATF6
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ATF6  GeneGlobe Interaction Network for ATF6
     Regulatory tfbs in ATF6 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ATF6 GenScript cDNA clones with any tag delivered in your preferred vector for ATF6
     GenScript Custom Assay Services for ATF6 GenScript Custom overexpressing Cell Line Services for ATF6
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ATF6 (ATF6A)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for ATF6
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ATF6 antibodies
     ATF6 proteins
     ATF6 lysates
     Antibodies for ATF6
     See all of Abcam's Antibodies, Kits and Proteins for ATF6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ATF6
     Antibodies for ATF6
     ELISAs for ATF6
     CLIAs for ATF6



     Browse ESI BIO Cell Lines and PureStem Progenitors for ATF6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATF6
     SwitchGear 3'UTR luciferase reporter plasmids for ATF6
     SwitchGear Promoter luciferase reporter plasmids for ATF6
     ThermoFisher Antibodies for ATF6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATF6
     Browse compounds at ApexBio
     Addgene plasmids for ATF6
      Search eBioscience for proteins for ATF6
      Search eBioscience for elisas for ATF6
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for ATF6
     antibodies-online antibodies for ATF6 (96 products)
     antibodies-online kits for ATF6 (21 products)
     antibodies-online peptides for ATF6
     antibodies-online proteins for ATF6 (6 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ATF6 gene at Home site.
    Version: 3.12.252 27 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4