ATF6 Gene
protein-coding GIFtS: 61
GCID: GC01P161736
|
|
activating transcription factor 6
| |
Aliases
for ATF6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Activating Transcription Factor 61 2 | | ATF6A1 2 | | CAMP-Dependent Transcription Factor ATF-6 Alpha2 3 | | Cyclic AMP-Dependent Transcription Factor ATF-6 Alpha2 | | ATF6-Alpha1 | | Activating Transcription Factor 6 Alpha3 |
Export aliases for ATF6 gene to outside databasesPrevious GC identifers: GC01P159370 GC01P157386 GC01P158432 GC01P158923 GC01P158467 GC01P160002 GC01P132981 |
Summaries
for ATF6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ATF6:
This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) duringendoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it issynthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, andfollowing ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stressresponse element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has beenidentified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have beenconflicting reports about the association of polymorphisms in this gene with diabetes in different populations, butanother polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be apotential therapeutic target for cystic fibrosis. (provided by RefSeq, Aug 2011)
UniProtKB/Swiss-Prot: ATF6A_HUMAN, P18850Function: Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein responsetarget genes. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3')and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved inactivation of transcription by the serum response factor
Gene Wiki entry for ATF6
|
Genomic Views
for ATF6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ATF6 gene promoter:
USF1 Tal-1 AML1a E47 CREB deltaCREB USF-1 c-Myb ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for ATF6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATF6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q22-q23 Ensembl cytogenetic band: 1q23.3 HGNC cytogenetic band: 1q22-q23ATF6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P161736: view genomic region
(about GC identifiers)
Start:
|
161,736,084 bp from pter |
End:
|
161,933,860 bp from pter |
Size:
|
197,777 bases |
Orientation:
|
plus strand |
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Proteins
for ATF6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ATF6A_HUMAN, P18850 (See
protein sequence)Recommended Name: Cyclic AMP-dependent transcription factor ATF-6 alpha Size: 670 amino acids; 74585 Da
Subunit: Homodimer and heterodimer with ATF6-beta. The dimer interacts with the nuclear transcription factor Y (NF-Y)trimer through direct binding to NF-Y subunit C (NF-YC). Interacts also with the transcription factors GTF2I, YY1 andSRF
Subcellular location: Endoplasmic reticulum membrane; Single-pass type II membrane protein
Subcellular location: Processed cyclic AMP-dependent transcription factor ATF-6 alpha: Nucleus. Note=Under ER stressthe cleaved N-terminal cytoplasmic domain translocates into the nucleus
Secondary accessions: O15139 Q5VW62 Q6IPB5 Q9UEC9Explore the universe of human proteins at neXtProt for ATF6: NX_P18850
Post-translational modifications:
During unfolded protein response an approximative 50 kDa fragment containing the cytoplasmic transcription factordomain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases1
N-glycosylated. The glycosylation status may serve as a sensor for ER homeostasis, resulting in ATF6 activation totrigger the unfolded protein response (UPR)1
Phosphorylated in vitro by MAPK14/P38MAPK1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P18850
ATF6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_031374.2
ENSEMBL proteins: ENSP00000356919 Reactome Protein details: P18850
Human Recombinant Protein Products for ATF6:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
ATF6 for ontologies About GeneDecksing
ATF6 Antibody Products:
Assay Products for ATF6: |
Protein
Domains /
Families
for ATF6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ATF6 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P18850ProtoNet protein and cluster: P18850 1 Blocks protein family: IPB011616 bZIP transcription factor
UniProtKB/Swiss-Prot: ATF6A_HUMAN, P18850Domain: The basic domain functions as a nuclear localization signalDomain: The basic leucine-zipper domain is sufficient for association with the NF-Y trimer and binding to ERSESimilarity: Belongs to the bZIP family. ATF subfamilySimilarity: Contains 1 bZIP (basic-leucine zipper) domain |
Function
for ATF6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ATF6A_HUMAN, P18850Function: Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein responsetarget genes. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3')and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved inactivation of transcription by the serum response factor Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
ATF6 for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for ATF6:
5 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Atf6):
ATF6 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Atf6tm1.1Rjk for ATF6
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATF6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATF6
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ATF6 (NM_001136153) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ATF6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATF6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATF6 |
|
Pathways & Interactions
for ATF6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/16 super-pathways (see all 16) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Activation of Chaperone Genes by ATF6-alpha | | | 2 | Rho Family GTPases | | | 3 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | | | 4 | SMAD Signaling Network | | | 5 | Signaling mediated by p38-alpha and p38-beta | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/10 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ATF6 (see all 10)
3  BioSystems Pathways for ATF6
5 
Reactome Pathways for ATF6
2 
Kegg Pathways (Kegg details for ATF6):
ATF6 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ATF6
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/30 Interacting proteins for ATF6 (P188501, 2, 3 ENSP000003569194) via UniProtKB, MINT, STRING, and/or I2D (see all 30)About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table
ATF6 for ontologies About GeneDecksing
|
Drugs & Compounds
for ATF6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ATF6 for compounds About GeneDecksing
 Browse Tocris compounds for ATF6
8 Novoseek chemical compound relationships for ATF6 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tunicamycin |
76.4 |
10 |
17101776 (2), 15845366 (1), 18022401 (1), 14973138 (1) (see all 7) |
| thapsigargin |
68 |
21 |
10866666 (4), 17307147 (2), 15845366 (1), 18022401 (1) (see all 8) |
| sterol |
41.5 |
5 |
14765107 (1), 18635952 (1), 12782636 (1), 16236796 (1) |
| leucine |
32.8 |
6 |
20219975 (1), 16725346 (1), 9837962 (1), 10866666 (1) (see all 6) |
| dithiothreitol |
31.4 |
1 |
17101776 (1) |
| inositol |
30.1 |
7 |
17349291 (1), 17178827 (1), 16205645 (1), 15799970 (1) |
| glucose |
9.32 |
17 |
17440018 (5), 17130669 (4), 14765107 (2), 20165829 (1) |
| calcium |
0 |
4 |
17167033 (1), 10866666 (1) |
Search CenterWatch for drugs/clinical trials and news about ATF6 / ATF6A
|
Transcripts
for ATF6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ATF6 gene: NM_007348.3 Unigene Cluster for ATF6: Activating transcription factor 6 Hs.492740 [show with all ESTs]Unigene Representative Sequence: NM_0073482 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000367942(uc001gbq.2 uc001gbs.3) ENST00000476437
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATF6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATF6
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ATF6 (NM_001136153) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ATF6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATF6 |
Additional cDNA sequence: AB015856.1 AB208929.1 AF005887.1 AF088035.1 AK025316.1 AK290498.1 BC014969.1 BC071997.1 BX538263.1 12 DOTS entries: DT.455847 DT.210704 DT.121437874 DT.121437859 DT.121437888 DT.408085 DT.421452 DT.92031898 DT.95375290 DT.100642555 DT.40310948 DT.95124201 24/298 AceView cDNA sequences (see all 298): BM719299 AA954768 AI564184 BE857991 BU154336 AI801738 AA468907 R74495 AI338298 BF939658 BX481749 CA393484 BM548776 AA974121 CB141899 AI655874 BP358704 BF221905 AI800956 BQ218179 AI357345 CN479360 W87752 BM721376
GeneLoc Exon Structure
|
Expression
for ATF6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ATF6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ATF6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ATF6
SOURCE GeneReport for Unigene cluster: Hs.492740
UniProtKB/Swiss-Prot: ATF6A_HUMAN, P18850Tissue specificity: Ubiquitous
SABiosciences Expression via Pathway-Focused PCR Arrays including ATF6:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATF6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ATF6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATF6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATF6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATF6 |
Orthologs
for ATF6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ATF6 gene from 5/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ATF61 |
activating transcription factor 6 |
68.08(n)
64.58(a) |
|
424365 XM_422208.3 XP_422208.3 |
lizard
(Anolis carolinensis) |
Reptilia |
ATF66 |
-- |
54(a) |
1 ↔ 1 |
4(71078371-71130029) |
zebrafish
(Danio rerio) |
Actinopterygii |
atf61 |
activating transcription factor 6 |
55.65(n)
48.28(a) |
|
558071 NM_001110519.1 NP_001103989.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Atf66 |
Atf6 |
15(a) |
1 → many |
2R(1032238-1042261) |
worm
(Caenorhabditis elegans) |
Secernentea |
atf-66 |
ATF (cAMP-dependent transciption factor) family me... |
19(a) |
1 → many |
X(12480880-12484811) |
ENSEMBL Gene Tree for ATF6 (if available)
TreeFam Gene Tree for ATF6 (if available) |
Paralogs
for ATF6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ATF6 gene
- ATF6B2
1 SIMAP similar gene for ATF6 using alignment to 1 protein entry: ATF6A_HUMAN:ATF6B
ATF6 for paralogs About GeneDecksing
|
Genomic Variants
for ATF6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ATF6 (161736084 - 161933860 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ATF6
1 CNV: 6791
Human Gene Mutation Database (HGMD): ATF6
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ATF6 |
|
Disorders
/ Diseases
for ATF6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ATF6 for disorders About GeneDecksing
OMIM gene information: 605537
OMIM disorders: --
20/36  diseases for ATF6 (see all 36): About MalaCardscystic fibrosis fibrosis west nile virus long qt syndrome
carcinoma cholesterol idiopathic pulmonary fibrosis wolfram syndrome
cytomegalovirus infection pulmonary fibrosis chronic lymphocytic leukemia lymphocytic leukemia
bipolar disorder multiple myeloma hepatocellular carcinoma ptosis
liposarcoma hepatitis c huntington's disease hepatitis b
2 Novoseek disease relationships for ATF6 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| ischemia |
0 |
7 |
19622751 (3) |
| hepatocellular carcinoma |
0 |
2 |
12713871 (1), 16364319 (1) |
Human Genome Epidemiology (HuGE) Navigator: ATF6 (11 documents)
Export disorders for ATF6 gene to outside databases
|
Publications
for ATF6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ATF6 gene, integrated from 9 sources (see all 186):
(articles sorted by number of sources associating them with ATF6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Interaction of ATF6 and serum response factor. (PubMed id 9271374)1, 2, 3, 9 Zhu C....Prywes R. (1997)
- Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins; involvement of basic-leucine zipper transcription factors. (PubMed id 9837962)1, 2, 3, 9 Yoshida H.... Mori K. (1998)
- Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response. (PubMed id 11256944)1, 3, 9 Haze K....Mori K. (2001)
- Underglycosylation of ATF6 as a novel sensing mechanism for activation of the unfolded protein response. (PubMed id 14699159)1, 2, 9 Hong M....Lee A.S. (2004)
- Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response. (PubMed id 11158310)1, 2, 9 Yoshida H....Mori K. (2001)
- The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis. (PubMed id 11483355)1, 2, 9 Hai T. and Hartman M.G. (2001)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. (PubMed id 11163209)1, 2 Ye J.... Goldstein J.L. (2000)
- Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. (PubMed id 10564271)1, 2 Haze K.... Mori K. (1999)
|
External Searches for ATF6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ATF6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ATF6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ATF6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ATF6 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ATF6 gene:
Search GeneIP for patents involving ATF6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ATF6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
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| | |  | OriGene Antibodies for ATF6 | | OriGene shRNA RFP for ATF6 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ATF6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATF6 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ATF6 | | OriGene 3'-UTR Clone for ATF6 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATF6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATF6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ATF6 | | OriGene Custom Protein Services for ATF6 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ATF6 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ATF6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATF6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ATF6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATF6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATF6 |
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| | | | Search Tocris compounds for ATF6 |
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 | | | ATF6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATF6 |
|  |  |  |  | | | | ThermoFisher Antibodies for ATF6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATF6 |
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