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Aliases for ATF5 Gene

Aliases for ATF5 Gene

  • Activating Transcription Factor 5 2 3 4 5
  • CAMP-Dependent Transcription Factor ATF-5 3 4
  • Transcription Factor ATFx 3 4
  • ATFX 3 4
  • HMFN0395 3

External Ids for ATF5 Gene

Previous GeneCards Identifiers for ATF5 Gene

  • GC19P051090
  • GC19P050800
  • GC19P055108
  • GC19P055124
  • GC19P050431
  • GC19P046808

Summaries for ATF5 Gene

GeneCards Summary for ATF5 Gene

ATF5 (Activating Transcription Factor 5) is a Protein Coding gene. Among its related pathways are ERK Signaling and TCR Signaling (Qiagen). GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription corepressor activity. An important paralog of this gene is ATF4.

UniProtKB/Swiss-Prot for ATF5 Gene

  • Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5-GTGACGT[AC][AG]-3), ATF5-specific response element (ARE) (consensus: 5-C[CT]TCT[CT]CCTT[AT]-3) but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation (PubMed:10373550, PubMed:15358120, PubMed:21212266, PubMed:20654631). Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4 (PubMed:15358120). Important regulator of the cerebral cortex formation, functions in cerebral cortical neuroprogenitor cells to maintain proliferation and to block differentiation into neurons. Must be down-regulated in order for such cells to exit the cycle and differentiate (By similarity). Participates in the pathways by which SHH promotes cerebellar granule neuron progenitor cells proliferation (By similarity). Critical for survival of mature olfactory sensory neurons (OSN), directs expression of OSN-specific genes (By similarity). May be involved in osteogenic differentiation (PubMed:22442021). Promotes cell proliferation and survival by inducing the expression of EGR1 sinergistically with ELK1. Once acetylated by EP300, binds to ARE sequences on target genes promoters, such as BCL2 and EGR1 (PubMed:21791614). Plays an anti-apoptotic role through the transcriptional regulation of BCL2, this function seems to be cell type-dependent (By similarity). Cooperates with NR1I3/CAR in the transcritpional activation of CYP2B6 in liver (PubMed:18332083). In hepatic cells, represses CRE-dependent transcription and inhibits proliferation by blocking at G2/M phase (PubMed:22528486, PubMed:18701499). May act as a negative regulator of IL1B transduction pathway in liver (PubMed:24379400). Upon IL1B stimulus, cooperates with NLK to activate the transactivation activity of C/EBP subfamily members (PubMed:25512613). Besides its function of transcription factor, acts as a cofactor of CEBPB to activate CEBPA and promote adipocyte differentiation (PubMed:24216764). Regulates centrosome dynamics in a cell-cycle- and centriole-age-dependent manner. Forms 9-foci symmetrical ring scaffold around the mother centriole to control centrosome function and the interaction between centrioles and pericentriolar material (PubMed:26213385).

Gene Wiki entry for ATF5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATF5 Gene

Genomics for ATF5 Gene

Regulatory Elements for ATF5 Gene

Enhancers for ATF5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ATF5 on UCSC Golden Path with GeneCards custom track

Promoters for ATF5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ATF5 on UCSC Golden Path with GeneCards custom track

Genomic Location for ATF5 Gene

Chromosome:
19
Start:
49,928,702 bp from pter
End:
49,933,936 bp from pter
Size:
5,235 bases
Orientation:
Plus strand

Genomic View for ATF5 Gene

Genes around ATF5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATF5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATF5 Gene

Proteins for ATF5 Gene

  • Protein details for ATF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2D1-ATF5_HUMAN
    Recommended name:
    Cyclic AMP-dependent transcription factor ATF-5
    Protein Accession:
    Q9Y2D1
    Secondary Accessions:
    • B3KND3
    • Q9BSA1
    • Q9UNQ3

    Protein attributes for ATF5 Gene

    Size:
    282 amino acids
    Molecular mass:
    30674 Da
    Quaternary structure:
    • Binds DNA as a dimer. Interacts with PTP4A1/PRL-1 (By similarity). Interacts with CCND3, but not with CCND1 or CCND2 (PubMed:15358120). Interacts with HSPA1A or HSPA1B; the interaction protects ATF5 from degradation via proteasome-dependent and caspase-dependent processes. Interacts (via C-terminal region) with NPM1 (via C-terminal region); the interaction leads to loss of association between HSPA1A or HSPA1B and ATF5 and promotes ATF5 degradation via proteasome-dependent and caspase-dependent processes (PubMed:22528486, PubMed:24379400). Interacts with NLK; the interaction stabilizes ATF5 at the protein level in a kinase-independent manner (PubMed:25512613). Interacts with alpha-tubulin, gamma-tubulin members TUBGCP2 and TUBGCP4, PCNT; the ATF5:PCNT:polyglutamylated tubulin (PGT) tripartite unites the mother centriole and the pericentriolar material (PCM) in the centrosome (PubMed:26213385). Interacts with CEBPB and EP300; EP300 is required for ATF5 and CEBPB interaction and DNA binding (By similarity).

neXtProt entry for ATF5 Gene

Proteomics data for ATF5 Gene at MOPED

Post-translational modifications for ATF5 Gene

  • Acetylated at Lys-29 by EP300, the acetylation enhances the interaction with CEBPB, DNA-binding and transactivation activity.
  • Phosphorylated by NLK, probably at Ser-92, Thr-94, Ser-126 and Ser-190.
  • Ubiquitinated by CDC34 and UBE2B in order to be degraded by the proteasome. Cisplatin inhibits ubiquitination and proteasome-mediated degradation by inhibiting the interaction with CDC34 (PubMed:18458088). Ubiquitination and degradation by the proteasome are inhibited by NLK in a kinase-independent manner (PubMed:25512613).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATF5 Gene

No data available for DME Specific Peptides for ATF5 Gene

Domains & Families for ATF5 Gene

Gene Families for ATF5 Gene

Protein Domains for ATF5 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ATF5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2D1

UniProtKB/Swiss-Prot:

ATF5_HUMAN :
  • Contains 1 bZIP (basic-leucine zipper) domain.
  • Belongs to the bZIP family.
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family.
genes like me logo Genes that share domains with ATF5: view

Function for ATF5 Gene

Molecular function for ATF5 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5-GTGACGT[AC][AG]-3), ATF5-specific response element (ARE) (consensus: 5-C[CT]TCT[CT]CCTT[AT]-3) but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation (PubMed:10373550, PubMed:15358120, PubMed:21212266, PubMed:20654631). Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4 (PubMed:15358120). Important regulator of the cerebral cortex formation, functions in cerebral cortical neuroprogenitor cells to maintain proliferation and to block differentiation into neurons. Must be down-regulated in order for such cells to exit the cycle and differentiate (By similarity). Participates in the pathways by which SHH promotes cerebellar granule neuron progenitor cells proliferation (By similarity). Critical for survival of mature olfactory sensory neurons (OSN), directs expression of OSN-specific genes (By similarity). May be involved in osteogenic differentiation (PubMed:22442021). Promotes cell proliferation and survival by inducing the expression of EGR1 sinergistically with ELK1. Once acetylated by EP300, binds to ARE sequences on target genes promoters, such as BCL2 and EGR1 (PubMed:21791614). Plays an anti-apoptotic role through the transcriptional regulation of BCL2, this function seems to be cell type-dependent (By similarity). Cooperates with NR1I3/CAR in the transcritpional activation of CYP2B6 in liver (PubMed:18332083). In hepatic cells, represses CRE-dependent transcription and inhibits proliferation by blocking at G2/M phase (PubMed:22528486, PubMed:18701499). May act as a negative regulator of IL1B transduction pathway in liver (PubMed:24379400). Upon IL1B stimulus, cooperates with NLK to activate the transactivation activity of C/EBP subfamily members (PubMed:25512613). Besides its function of transcription factor, acts as a cofactor of CEBPB to activate CEBPA and promote adipocyte differentiation (PubMed:24216764). Regulates centrosome dynamics in a cell-cycle- and centriole-age-dependent manner. Forms 9-foci symmetrical ring scaffold around the mother centriole to control centrosome function and the interaction between centrioles and pericentriolar material (PubMed:26213385).
UniProtKB/Swiss-Prot Induction:
Down-regulated by pro-apoptotic stimuli (PubMed:21212266). However, the pro-apoptotic cisplatin increases protein levels by inhibiting polyubiquitination (PubMed:18458088). IL1B increases protein levels through protein stabilization and increase of translation efficiency (PubMed:24379400).

Gene Ontology (GO) - Molecular Function for ATF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003714 transcription corepressor activity TAS 10373550
GO:0005515 protein binding IEA,IPI 10373550
genes like me logo Genes that share ontologies with ATF5: view
genes like me logo Genes that share phenotypes with ATF5: view

Animal Models for ATF5 Gene

MGI Knock Outs for ATF5:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ATF5 Gene

Localization for ATF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATF5 Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Actively transported to the centrosome and accumulated in the pericentriolar material (PCM) during G1 to M phase via a microtubule-dependent mechanism. During late telophase and cytokinesis, translocates from the centrosome to the midbody. {ECO:0000269 PubMed:26213385}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATF5 Gene COMPARTMENTS Subcellular localization image for ATF5 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ATF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 22528486
genes like me logo Genes that share ontologies with ATF5: view

Pathways & Interactions for ATF5 Gene

genes like me logo Genes that share pathways with ATF5: view

Gene Ontology (GO) - Biological Process for ATF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA,IDA 20654631
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA,TAS 10373550
GO:0006366 transcription from RNA polymerase II promoter IC --
GO:0021891 olfactory bulb interneuron development IEA --
GO:0021930 cerebellar granule cell precursor proliferation IEA,ISS --
genes like me logo Genes that share ontologies with ATF5: view

No data available for SIGNOR curated interactions for ATF5 Gene

Drugs & Compounds for ATF5 Gene

(2) Drugs for ATF5 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pseudoephedrine Approved Pharma Target 548
cyclic amp Experimental Pharma 0
genes like me logo Genes that share compounds with ATF5: view

Transcripts for ATF5 Gene

Unigene Clusters for ATF5 Gene

Activating transcription factor 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATF5 Gene

No ASD Table

Relevant External Links for ATF5 Gene

GeneLoc Exon Structure for
ATF5
ECgene alternative splicing isoforms for
ATF5

Expression for ATF5 Gene

mRNA expression in normal human tissues for ATF5 Gene

mRNA differential expression in normal tissues according to GTEx for ATF5 Gene

This gene is overexpressed in Liver (x34.1).

SOURCE GeneReport for Unigene cluster for ATF5 Gene Hs.9754

mRNA Expression by UniProt/SwissProt for ATF5 Gene

Q9Y2D1-ATF5_HUMAN
Tissue specificity: Widely expressed with higher expression levels in liver.
genes like me logo Genes that share expression patterns with ATF5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ATF5 Gene

Orthologs for ATF5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ATF5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ATF5 35
  • 84.78 (n)
  • 85.14 (a)
ATF5 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATF5 35
  • 85.13 (n)
  • 82.01 (a)
ATF5 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atf5 35
  • 84.16 (n)
  • 85.46 (a)
Atf5 16
Atf5 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ATF5 35
  • 99.17 (n)
  • 98.94 (a)
ATF5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atf5 35
  • 82.14 (n)
  • 84.29 (a)
lizard
(Anolis carolinensis)
Reptilia ATF5 36
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.511 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15540 35
zebrafish
(Danio rerio)
Actinopterygii wufc14a10 35
atf5a 36
  • 22 (a)
OneToMany
atf5b 36
  • 19 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2402 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2035 36
  • 19 (a)
OneToMany
Species with no ortholog for ATF5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATF5 Gene

ENSEMBL:
Gene Tree for ATF5 (if available)
TreeFam:
Gene Tree for ATF5 (if available)

Paralogs for ATF5 Gene

Paralogs for ATF5 Gene

genes like me logo Genes that share paralogs with ATF5: view

Variants for ATF5 Gene

Sequence variations from dbSNP and Humsavar for ATF5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_022786 -
rs8101009 -- 49,934,271(+) GGGGG(A/G)GGTGG downstream-variant-500B
rs8101308 -- 49,934,262(+) aaaaa(A/G)GGGGG downstream-variant-500B
rs8101314 -- 49,934,263(+) aaaaG(A/G)GGGGG downstream-variant-500B
rs71969937 -- 49,934,271(+) GGGGG(-/A)GGTGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ATF5 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
dgv53n68 CNV Loss 17160897
dgv54n68 CNV Loss 17160897
nsv458720 CNV Gain 19166990
nsv7309 OTHER Inversion 18451855

Variation tolerance for ATF5 Gene

Residual Variation Intolerance Score: 77.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.83; 47.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATF5 Gene

Human Gene Mutation Database (HGMD)
ATF5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATF5 Gene

Disorders for ATF5 Gene

Relevant External Links for ATF5

Genetic Association Database (GAD)
ATF5
Human Genome Epidemiology (HuGE) Navigator
ATF5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATF5

No disorders were found for ATF5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATF5 Gene

Publications for ATF5 Gene

  1. Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis. (PMID: 10373550) Pati D. … Plon S.E. (Mol. Cell. Biol. 1999) 2 3 4 67
  2. Identification of a novel DNA binding site and a transcriptional target for activating transcription factor 5 in c6 glioma and mcf-7 breast cancer cells. (PMID: 19531563) Li G. … Liu D.X. (Mol. Cancer Res. 2009) 3 23
  3. The bZIP transcription factor ATFx binds human T-cell leukemia virus type 1 (HTLV-1) Tax and represses HTLV-1 long terminal repeat-mediated transcription. (PMID: 15890932) Forgacs E. … Semmes O.J. (J. Virol. 2005) 3 23
  4. Regulation of asparagine synthetase gene transcription by the basic region leucine zipper transcription factors ATF5 and CHOP. (PMID: 16164412) Al Sarraj J. … Thiel G. (Biol. Chem. 2005) 3 23
  5. Stabilization of ATF5 by TAK1-Nemo-like kinase critically regulates the interleukin-1I^-stimulated C/EBP signaling pathway. (PMID: 25512613) Zhang Z.Y. … Zhang X.D. (Mol. Cell. Biol. 2015) 3

Products for ATF5 Gene

Sources for ATF5 Gene

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