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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ATF5 Gene

protein-coding   GIFtS: 55
GCID: GC19P050431

activating transcription factor 5
 Explore 15 diseases affiliated with
ATF5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ATF5    

Aliases
for ATF5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Activating Transcription Factor 51 2 3
ATFX2 3 5
Transcription Factor ATFx2 3
CAMP-Dependent Transcription Factor ATF-52 3
HMFN03952
Cyclic AMP-Dependent Transcription Factor ATF-52

External Ids:    HGNC: 7901   Entrez Gene: 228092   Ensembl: ENSG000001691367   OMIM: 6063985   UniProtKB: Q9Y2D13   
ORGUL members:         
NONCODE:n338898    

Export aliases for ATF5 gene to outside databases

Previous GC identifers: GC19P051090 GC19P050800 GC19P055108 GC19P055124 GC19P046808


Summaries
for ATF5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: ATF5_HUMAN, Q9Y2D1
Function: Transcriptional activator which binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a
sequence present in many viral and cellular promoters and blocks the differentiation of neuroprogenitor cells into
neurons. Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4

Gene Wiki entry for ATF5


Genomic Views
for ATF5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ATF5 gene promoter:
         Spz1   ISGF-3   AML1a   AP-1   ATF-2   MyoD   MZF-1   c-Jun   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ATF5 promoter sequence
   Search SABiosciences Chromatin IP Primers for ATF5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATF5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.3

ATF5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATF5 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P050431:  view genomic region     (about GC identifiers)

Start:
 50,431,959 bp from pter      End:
 50,437,193 bp from pter
Size:
 5,235 bases      Orientation:
 plus strand

Proteins
for ATF5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ATF5_HUMAN, Q9Y2D1 (See protein sequence)
Recommended Name: Cyclic AMP-dependent transcription factor ATF-5  
Size: 282 amino acids; 30674 Da
Subunit: Binds DNA as a dimer. Interacts with PTP4A1/PRL-1 (By similarity). Interacts with CCND3, but not with CCND1 or
CCND2. Interacts with CDC34
Subcellular location: Cytoplasm. Nucleus
Secondary accessions: B3KND3 Q9BSA1 Q9UNQ3

Explore the universe of human proteins at neXtProt for ATF5: NX_Q9Y2D1

Post-translational modifications:

  • Ubiquitinated by CDC34 and UBE2B in order to be degraded by the proteasome1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y2D1

    • ATF5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001180575.1  NP_036200.2  

    ENSEMBL proteins: 
     ENSP00000396954  

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    Novus Biologicals ATF5 Proteins
    Novus Biologicals ATF5 Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ATF5

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005667transcription factor complex IEA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--


    ATF5 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ATF5

    Protein Domains /
    Families
    for ATF5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ATF5 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR004827 bZIP

    Graphical View of Domain Structure for InterPro Entry Q9Y2D1

    ProtoNet protein and cluster: Q9Y2D1

    1 Blocks protein family: IPB011616 bZIP transcription factor

    UniProtKB/Swiss-Prot: ATF5_HUMAN, Q9Y2D1
    Similarity: Belongs to the bZIP family
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    Function
    for ATF5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ATF5_HUMAN, Q9Y2D1
    Function: Transcriptional activator which binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a
    sequence present in many viral and cellular promoters and blocks the differentiation of neuroprogenitor cells into
    neurons. Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ATF5
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate ATF5:
    hsa-miR-141 hsa-miR-610 hsa-miR-200a hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmid: ATF5 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ATF5 (see all 7)
    OriGene shRNA RFP: ATF5
    OriGene siRNA: ATF5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ATF5

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ATF5

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATF5 

    Cell Line
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    Search LifeMap BioReagents cell lines for ATF5

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATF5

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003714transcription corepressor activity TAS10373550
    GO:0005515protein binding IPI12812986
    GO:0031072heat shock protein binding IEA--
    GO:0043565sequence-specific DNA binding IEA--


    ATF5 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ATF5:
     Synthetic lethal with imatinib 

    Animal Models:
         7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Atf5):
     behavior/neurological  craniofacial  growth/size  mortality/aging  nervous system 
     respiratory system  taste/olfaction 

    ATF5 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ATF5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Rho Family GTPases
    		MAPK Signaling0.51
    		ILK Signaling0.45
    2SMAD Signaling Network
    		SMAD Signaling Network1.00
    3Signaling events mediated by PRL
    		Signaling events mediated by PRL1.00
    4PKC-Theta Pathway
    		ITK and TCR Signaling0.54
    5Calcium Regulation in the Cardiac Cell
    		Myometrial Relaxation and Contraction Pathways0.43

    5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ATF5 (see all 9)
        MAPK Signaling
    PI3K Signaling in B-Lymphocyte
    TNF Signaling
    iNOS Signaling
    SMAD Signaling Network

    2 BioSystems Pathways for ATF5 
        Myometrial Relaxation and Contraction Pathways
    Signaling events mediated by PRL


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ATF5

    5/14 Interacting proteins for ATF5 (Q9Y2D11, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DISC1Q9NRI51, 3EBI-492509,EBI-529989 I2D: score=4 
    CEBPGP535673I2D: score=4 
    CDC34P494273I2D: score=3 
    GABBR1Q9UBS53I2D: score=2 
    TRIB3Q96RU73I2D: score=2 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter IEA--
    GO:0043066negative regulation of apoptotic process IEA--
    GO:0048712negative regulation of astrocyte differentiation IEA--
    GO:0050768negative regulation of neurogenesis ----


    ATF5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ATF5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ATF5

    1 HMDB Compound for ATF5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    Search CenterWatch for drugs/clinical trials and news about ATF5 

    Transcripts
    for ATF5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ATF5 gene (2 alternative transcripts): 
    NM_001193646.1  NM_012068.5  

    Unigene Cluster for ATF5:

    Activating transcription factor 5
    Hs.9754  [show with all ESTs]
    Unigene Representative Sequence: NM_012068
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000423777(uc010enq.2 uc002prd.3)

    miRNA
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    hsa-miR-141 hsa-miR-610 hsa-miR-200a hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmid: ATF5 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ATF5 (see all 7)
    OriGene shRNA RFP: ATF5
    OriGene siRNA: ATF5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ATF5
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): ATF5 (NM_012068)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATF5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATF5 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATF5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATF5

    Additional cDNA sequence: 

    AB021663.2 AB073613.1 AF101388.1 AF305687.1 AK024402.1 AK091985.1 AK290592.1 BC005174.2 
    BC113092.1 BC125022.1 

    23 DOTS entries:

    DT.85105510  DT.92463481  DT.100785219  DT.100801322  DT.92463464  DT.100801321  DT.121429393  DT.92463452 
    DT.92463454  DT.92463470  DT.92463469  DT.92463479  DT.92463445  DT.100033563  DT.95220795  DT.121429494 
    DT.121429547  DT.95236903  DT.100785220  DT.92463487  DT.121429557  DT.86821331  DT.92463451 

    24/370 AceView cDNA sequences (see all 370):

    BI870273 BQ673832 BM704384 AL531375 BQ672247 BQ061794 AI499815 CA429625 
    BQ224450 BM763064 BQ050809 BQ057116 BE207819 AA421049 AB073613 BQ064402 
    BM932122 BU173636 AA345127 AW675052 BX405500 BE732543 BE732759 AF305687 

    GeneLoc Exon Structure


    Expression
    for ATF5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ATF5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCACTCCTGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ATF5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainHypothalamusBrain
    EyeRetinaEye
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    N2/LSB/S/F8/CHIR-induced cells (Generation of midbra...)

    See ATF5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ATF5

    SOURCE GeneReport for Unigene cluster: Hs.9754
        SABiosciences Expression via Pathway-Focused PCR Arrays including ATF5: 
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for ATF5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ATF5 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Atf51 , 5 activating transcription factor 51, 5 85.17(n)1
    87.54(a)1    		   7 (28.92 cM)5
    1075031  NM_030693.21  NP_109618.11 
     448122575 
    lizard
    (Anolis carolinensis)    		 Reptilia ATF56
    		 --
    		 49(a)
    		 1 ↔ 1
    		 GL343253.1(1553826-1555331)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.155402 Xenopus laevis transcribed sequence with weak similarity to protein refNP_036200.2 (H.sapiens) activating transcription factor 5 [Homo sapiens] less 81.66(n)    CD300825.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufc14a102 wufc14a10 79.5(n)   323917  CK360058.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta crc6
    		 cryptocephal
    		 13(a)
    		 1 → many
    		 2L(21310866-21319527)


    ENSEMBL Gene Tree for ATF5 (if available)
    TreeFam Gene Tree for ATF5 (if available) 

    Paralogs
    for ATF5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ATF5 gene
    ATF42  

    ATF5 for paralogs           About GeneDecksing



    Genomic Variants
    for ATF5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/181 NCBI SNPs in ATF5 are shown (see all 181)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs794314161,2
    		--46806700(+) CACTTC/TGTACC 4 -- int10--------
    rs362201321,2
    		C,F,--46806848(+) CCACAT/CTGAAG 4 -- int11Minor allele frequency- C:0.06WA 118
    rs1157929951,2
    		C,F,--46807400(+) AAGATG/TGCTAC 4 -- int11Minor allele frequency- T:0.03WA 118
    rs739320111,2
    		C,--46807438(+) TCCATG/TTTTGG 4 -- int11Minor allele frequency- T:0.50WA 2
    rs362201281,2
    		C,F,--46807603(+) ATGAGG/AATAGC 4 -- int11Minor allele frequency- A:0.03NA 120
    rs362201251,2
    		C--46807984(+) AGATCG/ACGCCA 4 -- int11Minor allele frequency- A:0.50CSA 2
    rs11522321,2
    		C,F,A,--46808682(+) CACCCA/GGTATA 4 -- int111Minor allele frequency- G:0.21NA WA CSA EA 484
    rs11522311,2
    		F--46808706(+) TCCCCA/GGGGCC 4 -- int11Minor allele frequency- G:0.48MN 184
    rs558245931,2
    		C,--46808959(+) CTTTCC/GCAGCT 4 -- ut51 nc-transcript-variant0--------
    rs768581071,2
    		F,--46809044(+) AGTACG/CGTGGG 4 -- ut51 nc-transcript-variant1Minor allele frequency- C:0.03NA 120

    HapMap Linkage Disequilibrium report for ATF5 (50431959 - 50437193 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for ATF5
         2 CNVs: 5114 32261
         2 Inversions: 37207 37208
    Human Gene Mutation Database (HGMD): ATF5

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ATF5
    DNA2.0 Custom Variant and Variant Library Synthesis for ATF5

    Disorders / Diseases
    for ATF5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ATF5 for disorders           About GeneDecksing

    OMIM gene information: 606398    OMIM disorders: --

    15 diseases for ATF5:    About MalaCards
    human t-cell leukemia virus type 1    acute lymphoblastic leukemia    lymphoblastic leukemia    malignant glioma
    bipolar disorder    t-cell leukemia    hepatoblastoma    leukemia
    hepatocellular carcinoma    breast cancer    glioblastoma    schizophrenia
    carcinoma    hepatitis    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: ATF5 (3 documents)

    Export disorders for ATF5 gene to outside databases

    Publications
    for ATF5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ATF5 gene, integrated from 9 sources (see all 45):
    (articles sorted by number of sources associating them with ATF5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis. (PubMed id 10373550)1, 2, 3 Pati D.... Plon S.E. (1999)
    2. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PubMed id 15221005)1, 2 Yamada S....Nakagawara A. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Cyclin D3 interacts with human activating transcription factor 5 and potentiates its transcription activity. (PubMed id 15358120)1, 2 Liu W.... Gu J. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx. (PubMed id 11087824)1, 2 White J.H.... Marshall F.H. (2000)
    7. The bZIP transcription factor ATFx binds human T-cell leukemia virus type 1 (HTLV-1) Tax and represses HTLV-1 long terminal repeat-mediated transcription. (PubMed id 15890932)1, 9 Forgacs E....Semmes O.J. (2005)
    8. Identification of a novel DNA binding site and a tran scriptional target for activating transcription factor 5 in c6 glioma and mcf-7 breast cancer cells. (PubMed id 19531563)1, 9 Li G....Liu D.X. (2009)
    9. Regulation of asparagine synthetase gene transcription by the basic region leucine zipper transcription factors ATF5 and CHOP. (PubMed id 16164412)1, 9 Al Sarraj J....Thiel G. (2005)
    10. Nucleophosmin (NPM1/B23) interacts with activating tra nscription factor 5 (ATF5) protein and promotes proteasome- and caspase-dependen t ATF5 degradation in hepatocellular carcinoma cells. (PubMed id 22528486)1 Liu X....Liu D.X. (2012)

    External Searches for ATF5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing ATF5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22809 HGNC: 790 AceView: ATF5 Ensembl:ENSG00000169136 euGenes: HUgn22809
    ECgene: ATF5 H-InvDB: ATF5

    Other Databases showing ATF5 gene

    (According to HUGE)
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    Specialized Databases showing ATF5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ATF5 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ATF5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ATF5 gene:
    Search GeneIP for patents involving ATF5

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