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Aliases for ATF5 Gene

Aliases for ATF5 Gene

  • Activating Transcription Factor 5 2 3 4
  • ATFX 3 4 6
  • CAMP-Dependent Transcription Factor ATF-5 3 4
  • Transcription Factor ATFx 3 4
  • Cyclic AMP-Dependent Transcription Factor ATF-5 3
  • HMFN0395 3

External Ids for ATF5 Gene

Summaries for ATF5 Gene

GeneCards Summary for ATF5 Gene

ATF5 (Activating Transcription Factor 5) is a Protein Coding gene. Diseases associated with ATF5 include human t-cell leukemia virus type 1. Among its related pathways are ERK Signaling and ERK Signaling. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription corepressor activity. An important paralog of this gene is ATF4.

UniProtKB/Swiss-Prot for ATF5 Gene

  • Transcriptional activator which binds the cAMP response element (CRE) (consensus: 5-GTGACGT[AC][AG]-3), a sequence present in many viral and cellular promoters and blocks the differentiation of neuroprogenitor cells into neurons. Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4.

Gene Wiki entry for ATF5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATF5 Gene

Genomics for ATF5 Gene

Genomic Location for ATF5 Gene

Start:
49,928,702 bp from pter
End:
49,933,936 bp from pter
Size:
5,235 bases
Orientation:
Plus strand

Genomic View for ATF5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATF5 Gene

Regulatory Elements for ATF5 Gene

Proteins for ATF5 Gene

  • Protein details for ATF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2D1-ATF5_HUMAN
    Recommended name:
    Cyclic AMP-dependent transcription factor ATF-5
    Protein Accession:
    Q9Y2D1
    Secondary Accessions:
    • B3KND3
    • Q9BSA1
    • Q9UNQ3

    Protein attributes for ATF5 Gene

    Size:
    282 amino acids
    Molecular mass:
    30674 Da
    Quaternary structure:
    • Binds DNA as a dimer. Interacts with PTP4A1/PRL-1 (By similarity). Interacts with CCND3, but not with CCND1 or CCND2. Interacts with CDC34.

neXtProt entry for ATF5 Gene

Proteomics data for ATF5 Gene at MOPED

Post-translational modifications for ATF5 Gene

  • Ubiquitinated by CDC34 and UBE2B in order to be degraded by the proteasome.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATF5 Gene

No data available for DME Specific Peptides for ATF5 Gene

Domains for ATF5 Gene

Gene Families for ATF5 Gene

HGNC:
  • bZIP :basic leucine zipper proteins

Protein Domains for ATF5 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

ATF5_HUMAN
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.:
    • Q9Y2D1
Family:
  • Belongs to the bZIP family.:
    • Q9Y2D1
genes like me logo Genes that share domains with ATF5: view

Function for ATF5 Gene

Molecular function for ATF5 Gene

UniProtKB/Swiss-Prot Function: Transcriptional activator which binds the cAMP response element (CRE) (consensus: 5-GTGACGT[AC][AG]-3), a sequence present in many viral and cellular promoters and blocks the differentiation of neuroprogenitor cells into neurons. Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4.

Gene Ontology (GO) - Molecular Function for ATF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IMP 15890932
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IC --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0003714 transcription corepressor activity TAS 10373550
GO:0005515 protein binding IPI 10373550
genes like me logo Genes that share ontologies with ATF5: view
genes like me logo Genes that share phenotypes with ATF5: view

miRNA for ATF5 Gene

miRTarBase miRNAs that target ATF5

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ATF5 Gene

Localization for ATF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATF5 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATF5 Gene COMPARTMENTS Subcellular localization image for ATF5 gene
Compartment Confidence
nucleus 5
cytosol 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ATF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005667 transcription factor complex IEA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ATF5: view

Pathways for ATF5 Gene

genes like me logo Genes that share pathways with ATF5: view

Gene Ontology (GO) - Biological Process for ATF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 10373550
GO:0007623 circadian rhythm IEA --
GO:0009791 post-embryonic development IEA --
genes like me logo Genes that share ontologies with ATF5: view

Compounds for ATF5 Gene

(1) HMDB Compounds for ATF5 Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic AMP
  • Cyclic AMP
60-92-4
genes like me logo Genes that share compounds with ATF5: view

Transcripts for ATF5 Gene

Unigene Clusters for ATF5 Gene

Activating transcription factor 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATF5 Gene

No ASD Table

Relevant External Links for ATF5 Gene

GeneLoc Exon Structure for
ATF5
ECgene alternative splicing isoforms for
ATF5

Expression for ATF5 Gene

mRNA expression in normal human tissues for ATF5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ATF5 Gene

This gene is overexpressed in Liver (34.1).

SOURCE GeneReport for Unigene cluster for ATF5 Gene Hs.9754

genes like me logo Genes that share expressions with ATF5: view

Orthologs for ATF5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ATF5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATF5 36
  • 99.17 (n)
  • 98.94 (a)
ATF5 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATF5 36
  • 84.78 (n)
  • 85.14 (a)
ATF5 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATF5 36
  • 85.13 (n)
  • 82.01 (a)
ATF5 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atf5 36
  • 84.16 (n)
  • 85.46 (a)
Atf5 16
Atf5 37
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atf5 36
  • 82.14 (n)
  • 84.29 (a)
lizard
(Anolis carolinensis)
Reptilia ATF5 37
  • 45 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15540 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.511 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2402 36
zebrafish
(Danio rerio)
Actinopterygii atf5a 37
  • 22 (a)
OneToMany
atf5b 37
  • 19 (a)
OneToMany
wufc14a10 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2035 37
  • 19 (a)
OneToMany
Species with no ortholog for ATF5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATF5 Gene

ENSEMBL:
Gene Tree for ATF5 (if available)
TreeFam:
Gene Tree for ATF5 (if available)

Paralogs for ATF5 Gene

Paralogs for ATF5 Gene

genes like me logo Genes that share paralogs with ATF5: view

Variants for ATF5 Gene

Sequence variations from dbSNP and Humsavar for ATF5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs8647 -- 49,933,723(+) AAGGC(A/G)GCCAG utr-variant-3-prime
rs283527 -- 49,934,301(+) ctcac(A/G)cctgt downstream-variant-500B
rs7247653 -- 49,934,202(+) tctat(C/T)gcact downstream-variant-500B
rs8101009 -- 49,934,271(+) GGGGG(A/G)GGTGG downstream-variant-500B
rs8101308 -- 49,934,262(+) aaaaa(A/G)GGGGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ATF5 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
dgv53n68 CNV Loss 17160897
dgv54n68 CNV Loss 17160897
nsv458720 CNV Gain 19166990
nsv7309 OTHER Inversion 18451855

Relevant External Links for ATF5 Gene

HapMap Linkage Disequilibrium report
ATF5
Human Gene Mutation Database (HGMD)
ATF5

Disorders for ATF5 Gene

Relevant External Links for ATF5

Genetic Association Database (GAD)
ATF5
Human Genome Epidemiology (HuGE) Navigator
ATF5
genes like me logo Genes that share disorders with ATF5: view

No data available for UniProtKB/Swiss-Prot for ATF5 Gene

Publications for ATF5 Gene

  1. Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis. (PMID: 10373550) Pati D. … Plon S.E. (Mol. Cell. Biol. 1999) 2 3 4
  2. The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx. (PMID: 11087824) White J.H. … Marshall F.H. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  3. Cyclin D3 interacts with human activating transcription factor 5 and potentiates its transcription activity. (PMID: 15358120) Liu W. … Gu J. (Biochem. Biophys. Res. Commun. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The bZIP transcription factor ATFx binds human T-cell leukemia virus type 1 (HTLV-1) Tax and represses HTLV-1 long terminal repeat-mediated transcription. (PMID: 15890932) Forgacs E. … Semmes O.J. (J. Virol. 2005) 3 23

Products for ATF5 Gene

Sources for ATF5 Gene

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