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ATF5 Gene

protein-coding   GIFtS: 57
GCID: GC19P050431

Activating Transcription Factor 5

  See ATF5-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Activating Transcription Factor 51 2 3
ATFX2 3 5
Transcription Factor ATFx2 3
CAMP-Dependent Transcription Factor ATF-52 3
HMFN03952
Cyclic AMP-Dependent Transcription Factor ATF-52

External Ids:    HGNC: 7901   Entrez Gene: 228092   Ensembl: ENSG000001691367   OMIM: 6063985   UniProtKB: Q9Y2D13   
ORGUL members:         

Export aliases for ATF5 gene to outside databases

Previous GC identifers: GC19P051090 GC19P050800 GC19P055108 GC19P055124 GC19P046808


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ATF5 Gene:
ATF5 (activating transcription factor 5) is a protein-coding gene. Diseases associated with ATF5 include human t-cell leukemia virus type 1. GO annotations related to this gene include transcription corepressor activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ATF4.

UniProtKB/Swiss-Prot: ATF5_HUMAN, Q9Y2D1
Function: Transcriptional activator which binds the cAMP response element (CRE) (consensus:
5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters and blocks the differentiation of
neuroprogenitor cells into neurons. Its transcriptional activity is enhanced by CCND3 and slightly inhibited by
CDK4

Gene Wiki entry for ATF5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ATF5 gene promoter:
         Spz1   ISGF-3   AML1a   AP-1   ATF-2   MyoD   MZF-1   c-Jun   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATF5 promoter sequence
   Search Chromatin IP Primers for ATF5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATF5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.33

ATF5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATF5 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P050431:  view genomic region     (about GC identifiers)

Start:
50,431,959 bp from pter      End:
50,437,193 bp from pter
Size:
5,235 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ATF5_HUMAN, Q9Y2D1 (See protein sequence)
Recommended Name: Cyclic AMP-dependent transcription factor ATF-5  
Size: 282 amino acids; 30674 Da
Subunit: Binds DNA as a dimer. Interacts with PTP4A1/PRL-1 (By similarity). Interacts with CCND3, but not with
CCND1 or CCND2. Interacts with CDC34
Secondary accessions: B3KND3 Q9BSA1 Q9UNQ3

Explore the universe of human proteins at neXtProt for ATF5: NX_Q9Y2D1

Explore proteomics data for ATF5 at MOPED

Post-translational modifications: 

  • Ubiquitinated by CDC34 and UBE2B in order to be degraded by the proteasome1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ATF5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001180575.1  NP_001277675.1  NP_036200.2  

    ENSEMBL proteins: 
     ENSP00000470633   ENSP00000396954   ENSP00000471162   ENSP00000470978   ENSP00000470464  

    ATF5 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for ATF5
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ATF5
    GenScript Custom Purified and Recombinant Proteins Services for ATF5
    Novus Biologicals ATF5 Proteins
    Novus Biologicals ATF5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ATF5

     
    Search eBioscience for Proteins for ATF5 

    ATF5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ATF5
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    Novus Biologicals ATF5 Antibodies
    Abcam antibodies for ATF5
    Cloud-Clone Corp. Antibodies for ATF5
    ThermoFisher Antibodies for ATF5
    LSBio Antibodies in human, mouse, rat for ATF5

    ATF5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ATF5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ATF5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ATF5
    Cloud-Clone Corp. CLIAs for ATF5
    Search eBioscience for ELISAs for ATF5 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bZIP: basic leucine zipper proteins

    1 InterPro protein domain:
     IPR004827 bZIP

    Graphical View of Domain Structure for InterPro Entry Q9Y2D1

    ProtoNet protein and cluster: Q9Y2D1

    1 Blocks protein domain: IPB011616 bZIP transcription factor

    UniProtKB/Swiss-Prot: ATF5_HUMAN, Q9Y2D1
    Similarity: Belongs to the bZIP family
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    Find genes that share domains with ATF5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATF5_HUMAN, Q9Y2D1
    Function: Transcriptional activator which binds the cAMP response element (CRE) (consensus:
    5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters and blocks the differentiation of
    neuroprogenitor cells into neurons. Its transcriptional activity is enhanced by CCND3 and slightly inhibited by
    CDK4

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003714transcription corepressor activity TAS10373550
    GO:0005515protein binding IPI10373550
    GO:0031072heat shock protein binding IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with ATF5           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ATF5:
     Synthetic lethal with imatinib 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Atf5):
     behavior/neurological  craniofacial  growth/size/body  mortality/aging  nervous system 
     respiratory system  taste/olfaction 

    Find genes that share phenotypes with ATF5           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ATF5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ATF5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ATF5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ATF5

    miRNA
    Products:
        
    miRTarBase miRNAs that target ATF5:
    hsa-mir-7-5p (MIRT025724), hsa-mir-222-3p (MIRT046831)

    Block miRNA regulation of human, mouse, rat ATF5 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate ATF5:
    hsa-miR-141 hsa-miR-610 hsa-miR-200a hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidATF5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ATF5
    Predesigned siRNA for gene silencing in human, mouse, rat ATF5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ATF5

    Clone
    Products:
         
    OriGene clones in human, mouse for ATF5 (see all 7)
    OriGene ORF clones in mouse, rat for ATF5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ATF5 (NM_012068)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATF5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATF5

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ATF5
    Browse ESI BIO Cell Lines and PureStem Progenitors for ATF5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATF5

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA6-12611) for ATF5 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ATF5_HUMAN, Q9Y2D1: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    endoplasmic reticulum1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005667transcription factor complex IEA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with ATF5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ATF5 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1ERK Signaling
    MAPK Signaling0.58
    ILK Signaling0.49
    2TWEAK Pathway
    TNF Signaling0.55
    3TCR Signaling (Qiagen)
    ITK and TCR Signaling0.54
    4Myometrial Relaxation and Contraction Pathways
    Myometrial Relaxation and Contraction Pathways0.43
    5Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ATF5 (see all 9)
        MAPK Signaling
    PI3K Signaling in B-Lymphocyte
    TNF Signaling
    iNOS Signaling
    SMAD Signaling Network

    2 BioSystems Pathways for ATF5
        Myometrial Relaxation and Contraction Pathways
    Signaling events mediated by PRL


        Pathway & Disease-focused RT2 Profiler PCR Arrays including ATF5: 
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ATF5

    Selected Interacting proteins for ATF5 (Q9Y2D11, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DISC1Q9NRI51, 3EBI-492509,EBI-529989 I2D: score=4 
    ENSG00000206466Q9UBS53I2D: score=2 
    ENSG00000206511Q9UBS53I2D: score=2 
    ENSG00000232569Q9UBS53I2D: score=2 
    ENSG00000232632Q9UBS53I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter IEA--
    GO:0009791post-embryonic development IEA--
    GO:0010468regulation of gene expression ----

    Find genes that share ontologies with ATF5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ATF5

    1 HMDB Compound for ATF5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ATF5 gene (3 alternative transcripts): 
    NM_001193646.1  NM_001290746.1  NM_012068.5  

    Unigene Cluster for ATF5:

    Activating transcription factor 5
    Hs.9754  [show with all ESTs]
    Unigene Representative Sequence: NM_012068
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000595125 ENST00000423777(uc010enq.2 uc002prd.3) ENST00000600336
    ENST00000597227 ENST00000596658
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ATF5 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate ATF5:
    hsa-miR-141 hsa-miR-610 hsa-miR-200a hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidATF5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ATF5
    Predesigned siRNA for gene silencing in human, mouse, rat ATF5
    Clone
    Products:
         
    OriGene clones in human, mouse for ATF5 (see all 7)
    OriGene ORF clones in mouse, rat for ATF5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ATF5 (NM_012068)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATF5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATF5
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ATF5
    OriGene qSTAR qPCR primer pairs in human, mouse for ATF5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ATF5
      QuantiTect SYBR Green Assays in human, mouse, rat ATF5
      QuantiFast Probe-based Assays in human, mouse, rat ATF5
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA6-12611) for ATF5 

    Additional mRNA sequence: 

    AB021663.2 AB073613.1 AF101388.1 AF305687.1 AK024402.1 AK091985.1 AK290592.1 BC005174.2 
    BC113092.1 BC125022.1 

    23 DOTS entries:

    DT.85105510  DT.92463481  DT.100785219  DT.100801322  DT.92463464  DT.100801321  DT.121429393  DT.92463452 
    DT.92463454  DT.92463470  DT.92463469  DT.92463479  DT.92463445  DT.100033563  DT.95220795  DT.121429494 
    DT.121429547  DT.95236903  DT.100785220  DT.92463487  DT.121429557  DT.86821331  DT.92463451 

    Selected AceView cDNA sequences (see all 370):

    BM476056 AI499815 AV651606 AW675052 BQ054512 CA432396 BQ672247 AF305687 
    BQ057116 BM704384 BQ061794 BX405500 Z39409 CA429625 BX100902 BQ065846 
    CB164126 BE732543 CR609432 CR592798 BQ673832 BQ224450 BM763064 BE732759 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ATF5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCACTCCTGG
    ATF5 Expression
    About this image


    ATF5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Thymus (Hematopoietic System)
             Thymus
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    ATF5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ATF5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.9754
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ATF5: 
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ATF5
    OriGene qSTAR qPCR primer pairs in human, mouse for ATF5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ATF5
    QuantiTect SYBR Green Assays in human, mouse, rat ATF5
    QuantiFast Probe-based Assays in human, mouse, rat ATF5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATF5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ATF5 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atf51 , 5 activating transcription factor 51, 5 84.16(n)1
    85.46(a)1
      7 (28.92 cM)5
    1075031  NM_030693.21  NP_109618.11 
     448122575 
    lizard
    (Anolis carolinensis)
    Reptilia ATF56
    activating transcription factor 5
    45(a)
    1 ↔ 1
    GL343253.1(1553826-1558181)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.155402 Xenopus laevis transcribed sequence with weak similarity more 81.66(n)    CD300825.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc14a102 wufc14a10 79.5(n)   323917  CK360058.1 


    ENSEMBL Gene Tree for ATF5 (if available)
    TreeFam Gene Tree for ATF5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ATF5 gene
    ATF42  

    Find genes that share paralogs with ATF5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ATF5 (see all 33)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs86671,2
    C,F,A,H--50436371(+) CTTCTA/C/GGGGGC 4 -- ut31 ese315MN NS EA NA WA CSA EU 1334
    rs86471,2
    C,F,H--50436980(+) AAGGCG/AGCCAG 2 -- ut3124Minor allele frequency- A:0.28MN NA NS EA WA 2854
    rs767483181,2
    C,F--50437060(+) GTGTTC/AATTTT 2 -- ut311Minor allele frequency- A:0.05EA 120
    rs1815810461,2
    --50437176(+) TAAAAC/TGAAAC 2 -- ut310--------
    rs621262971,2
    C,F--50437233(+) AGAGGC/TGGCCT 2 -- int15Minor allele frequency- T:0.18NA CSA WA EA 362
    rs116661661,2
    C,F,A,H--50437246(+) taatcT/Gcagca 2 -- int16Minor allele frequency- G:0.09NA 130
    rs1483433441,2
    --50437370(+) CGTGTA/GCCTGT 2 -- int10--------
    rs72476531,2
    C,F,H--50437459(+) tctatT/Cgcact 2 -- int19Minor allele frequency- C:0.31NS EA NA WA 772
    rs1415354201,2
    C--50437462(+) ATTGCA/CCTCCA 2 -- int10--------
    rs81013081,2
    C,A,H--50437519(+) aaaaaA/GGGGGG 2 -- int10--------

    HapMap Linkage Disequilibrium report for ATF5 (50431959 - 50437193 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ATF5:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv53n68CNV Loss17160897
    dgv54n68CNV Loss17160897
    nsv458720CNV Gain19166990
    nsv9739CNV Gain+Loss18304495
    nsv7309OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): ATF5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ATF5
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606398    OMIM disorders: --

    1 disease for ATF5:    
    About MalaCards
    human t-cell leukemia virus type 1


    Find genes that share disorders with ATF5           About GenesLikeMe

    Genetic Association Database (GAD): ATF5
    Human Genome Epidemiology (HuGE) Navigator: ATF5 (3 documents)

    Export disorders for ATF5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ATF5 gene, integrated from 10 sources (see all 52):
    (articles sorted by number of sources associating them with ATF5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis. (PubMed id 10373550)1, 2, 3 Pati D.... Plon S.E. (Mol. Cell. Biol. 1999)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses. (PubMed id 19251251)1, 4 Tomppo L....Peltonen L. (Biol. Psychiatry 2009)
    4. Association analysis of ATF4 and ATF5, genes for interacting-proteins of DISC1, in bipolar disorder. (PubMed id 17346882)1, 4 Kakiuchi C....Kato T. (Neurosci. Lett. 2007)
    5. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PubMed id 15221005)1, 2 Yamada S....Nakagawara A. (Oncogene 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Cyclin D3 interacts with human activating transcription factor 5 and potentiates its transcription activity. (PubMed id 15358120)1, 2 Liu W.... Gu J. (Biochem. Biophys. Res. Commun. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx. (PubMed id 11087824)1, 2 White J.H.... Marshall F.H. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    10. The bZIP transcription factor ATFx binds human T-cell leukemia virus type 1 (HTLV-1) Tax and represses HTLV-1 long terminal repeat-mediated transcription. (PubMed id 15890932)1, 9 Forgacs E....Semmes O.J. (J. Virol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 22809 HGNC: 790 AceView: ATF5 Ensembl:ENSG00000169136 euGenes: HUgn22809
    ECgene: ATF5 H-InvDB: ATF5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ATF5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ATF5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ATF5 gene:
    Search GeneIP for patents involving ATF5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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