ATF5 Gene

Aliases
for ATF5 gene

Previous GC identifers: GC19P051090 GC19P050800 GC19P055108 GC19P055124 GC19P046808

Summaries
for ATF5 gene

Genomic Views
for ATF5 gene

RefSeq DNA sequence:

NC_000019.9  NC_018930.1  NT_011109.16  

SwitchGear Promoter luciferase reporter plasmid: ATF5 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATF5

ATF5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P050431:  view genomic region     (about GC identifiers)

Proteins
for ATF5 gene

Explore the universe of human proteins at neXtProt for ATF5: NX_Q9Y2D1

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: ATF5 OriGene Custom Protein Services for ATF5
	GenScript Custom Purified and Recombinant Proteins Services for ATF5
	Novus Biologicals ATF5 Proteins Novus Biologicals ATF5 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ATF5

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies: ATF5 OriGene Custom Antibody Services for ATF5
	GenScript Custom Superior Antibodies Services for ATF5
	Novus Biologicals ATF5 Antibodies
	Search for Antibodies for ATF5 at Abcam
	Uscn Antibodies for ATF5
	ThermoFisher Antibodies for ATF5

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ATF5
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ATF5

Protein Domains /
Families
for ATF5 gene

ProtoNet protein and cluster: Q9Y2D1

Function
for ATF5 gene

miRNA Products:		OriGene 3'-UTR Clone: ATF5 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ATF5
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate ATF5:
		hsa-miR-141 hsa-miR-610 hsa-miR-200a hsa-miR-3662
		SwitchGear 3'UTR luciferase reporter plasmid: ATF5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ATF5 (see all 7) OriGene shRNA RFP: ATF5 OriGene siRNA: ATF5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ATF5

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for ATF5

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATF5 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATF5 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): ATF5 (NM_012068)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATF5
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATF5

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ATF5
		Search LifeMap BioReagents cell lines for ATF5

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATF5

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

(inferred from 1 allele) (MGI details for Atf5)

Pathways & Interactions
for ATF5 gene

	Super-pathway	contained gene-specific pathways
1	Rho Family GTPases	MAPK Signaling 0.51 ILK Signaling 0.45
2	SMAD Signaling Network	SMAD Signaling Network 1.00
3	Signaling events mediated by PRL	Signaling events mediated by PRL 1.00
4	PKC-Theta Pathway	ITK and TCR Signaling 0.54
5	Calcium Regulation in the Cardiac Cell	Myometrial Relaxation and Contraction Pathways 0.43

5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ATF5

	MAPK Signaling
	PI3K Signaling in B-Lymphocyte
	TNF Signaling
	iNOS Signaling
	SMAD Signaling Network

2 BioSystems Pathways for ATF5

	Myometrial Relaxation and Contraction Pathways
	Signaling events mediated by PRL

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for ATF5 gene

Transcripts
for ATF5 gene

Expression
for ATF5 gene

ATF5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCACTCCTGG

2 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	BrainHypothalamus			Brain
	EyeRetina			Eye
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	N2/LSB/S/F8/CHIR-induced cells (Generation of midbra...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATF5 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ATF5
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATF5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATF5

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATF5

Orthologs
for ATF5 gene

Paralogs
for ATF5 gene

Paralogs for ATF5 gene

ATF4²  

ATF5 for paralogs           About GeneDecksing

Genomic Variants
for ATF5 gene

10/181 NCBI SNPs in ATF5 are shown (see all 181)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs794314161,2		--	46806700(+)	CACTTC/TGTACC	4	--	int1		0	--	--	--	--
rs362201321,2	C,F,	--	46806848(+)	CCACAT/CTGAAG	4	--	int1		1		WA	118
rs1157929951,2	C,F,	--	46807400(+)	AAGATG/TGCTAC	4	--	int1		1		WA	118
rs739320111,2	C,	--	46807438(+)	TCCATG/TTTTGG	4	--	int1		1		WA	2
rs362201281,2	C,F,	--	46807603(+)	ATGAGG/AATAGC	4	--	int1		1		NA	120
rs362201251,2	C	--	46807984(+)	AGATCG/ACGCCA	4	--	int1		1		CSA	2
rs11522321,2	C,F,A,	--	46808682(+)	CACCCA/GGTATA	4	--	int1		11		NA WA CSA EA	484
rs11522311,2	F	--	46808706(+)	TCCCCA/GGGGCC	4	--	int1		1		MN	184
rs558245931,2	C,	--	46808959(+)	CTTTCC/GCAGCT	4	--	ut51 nc-transcript-variant		0	--	--	--	--
rs768581071,2	F,	--	46809044(+)	AGTACG/CGTGGG	4	--	ut51 nc-transcript-variant		1		NA	120

HapMap Linkage Disequilibrium report for ATF5 (50431959 - 50437193 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for ATF5
     2 CNVs: 5114 32261
     2 Inversions: 37207 37208
Human Gene Mutation Database (HGMD): ATF5

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ATF5

DNA2.0 Custom Variant and Variant Library Synthesis for ATF5

Disorders / Diseases
for ATF5 gene

Publications
for ATF5 gene

PubMed articles for ATF5 gene, integrated from 9 sources (see all 45): (articles sorted by number of sources associating them with ATF5)

Utopia: connect your pdf to the dynamic world of online information

1. Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis. (PubMed id 10373550)^{1, 2, 3} Pati D.... Plon S.E. (1999)
2. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PubMed id 15221005)^{1, 2} Yamada S....Nakagawara A. (2004)
3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
4. Cyclin D3 interacts with human activating transcription factor 5 and potentiates its transcription activity. (PubMed id 15358120)^{1, 2} Liu W.... Gu J. (2004)
5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
6. The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx. (PubMed id 11087824)^{1, 2} White J.H.... Marshall F.H. (2000)
7. The bZIP transcription factor ATFx binds human T-cell leukemia virus type 1 (HTLV-1) Tax and represses HTLV-1 long terminal repeat-mediated transcription. (PubMed id 15890932)^{1, 9} Forgacs E....Semmes O.J. (2005)
8. Identification of a novel DNA binding site and a tran scriptional target for activating transcription factor 5 in c6 glioma and mcf-7 breast cancer cells. (PubMed id 19531563)^{1, 9} Li G....Liu D.X. (2009)
9. Regulation of asparagine synthetase gene transcription by the basic region leucine zipper transcription factors ATF5 and CHOP. (PubMed id 16164412)^{1, 9} Al Sarraj J....Thiel G. (2005)
10. Nucleophosmin (NPM1/B23) interacts with activating tra nscription factor 5 (ATF5) protein and promotes proteasome- and caspase-dependen t ATF5 degradation in hepatocellular carcinoma cells. (PubMed id 22528486)¹ Liu X....Liu D.X. (2012)

External Searches for ATF5 gene

Genome Databases showing ATF5 gene

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Products
for ATF5 gene