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Aliases for ATF5 Gene

Aliases for ATF5 Gene

  • Activating Transcription Factor 5 2 3 4
  • CAMP-Dependent Transcription Factor ATF-5 3 4
  • Transcription Factor ATFx 3 4
  • ATFX 3 4
  • HMFN0395 3

External Ids for ATF5 Gene

Previous GeneCards Identifiers for ATF5 Gene

  • GC19P051090
  • GC19P050800
  • GC19P055108
  • GC19P055124
  • GC19P050431
  • GC19P046808

Summaries for ATF5 Gene

GeneCards Summary for ATF5 Gene

ATF5 (Activating Transcription Factor 5) is a Protein Coding gene. Among its related pathways are ERK Signaling and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription corepressor activity. An important paralog of this gene is ATF4.

UniProtKB/Swiss-Prot for ATF5 Gene

  • Transcriptional activator which binds the cAMP response element (CRE) (consensus: 5-GTGACGT[AC][AG]-3), a sequence present in many viral and cellular promoters and blocks the differentiation of neuroprogenitor cells into neurons. Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4.

Gene Wiki entry for ATF5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATF5 Gene

Genomics for ATF5 Gene

Regulatory Elements for ATF5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ATF5 Gene

Chromosome:
19
Start:
49,928,702 bp from pter
End:
49,933,936 bp from pter
Size:
5,235 bases
Orientation:
Plus strand

Genomic View for ATF5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATF5 Gene

Proteins for ATF5 Gene

  • Protein details for ATF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2D1-ATF5_HUMAN
    Recommended name:
    Cyclic AMP-dependent transcription factor ATF-5
    Protein Accession:
    Q9Y2D1
    Secondary Accessions:
    • B3KND3
    • Q9BSA1
    • Q9UNQ3

    Protein attributes for ATF5 Gene

    Size:
    282 amino acids
    Molecular mass:
    30674 Da
    Quaternary structure:
    • Binds DNA as a dimer. Interacts with PTP4A1/PRL-1 (By similarity). Interacts with CCND3, but not with CCND1 or CCND2. Interacts with CDC34.

neXtProt entry for ATF5 Gene

Proteomics data for ATF5 Gene at MOPED

Post-translational modifications for ATF5 Gene

  • Ubiquitinated by CDC34 and UBE2B in order to be degraded by the proteasome.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATF5 Gene

No data available for DME Specific Peptides for ATF5 Gene

Domains & Families for ATF5 Gene

Gene Families for ATF5 Gene

Protein Domains for ATF5 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ATF5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2D1

UniProtKB/Swiss-Prot:

ATF5_HUMAN :
  • Contains 1 bZIP (basic-leucine zipper) domain.
  • Belongs to the bZIP family.
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family.
genes like me logo Genes that share domains with ATF5: view

Function for ATF5 Gene

Molecular function for ATF5 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator which binds the cAMP response element (CRE) (consensus: 5-GTGACGT[AC][AG]-3), a sequence present in many viral and cellular promoters and blocks the differentiation of neuroprogenitor cells into neurons. Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4.

Gene Ontology (GO) - Molecular Function for ATF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IMP 15890932
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IC --
GO:0003682 chromatin binding IDA 21212266
GO:0003700 transcription factor activity, sequence-specific DNA binding ISS --
genes like me logo Genes that share ontologies with ATF5: view
genes like me logo Genes that share phenotypes with ATF5: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATF5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ATF5 Gene

Localization for ATF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATF5 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATF5 Gene COMPARTMENTS Subcellular localization image for ATF5 gene
Compartment Confidence
nucleus 4
cytosol 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ATF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22528486
GO:0005654 nucleoplasm IDA --
GO:0005667 transcription factor complex IEA --
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA 26213385
genes like me logo Genes that share ontologies with ATF5: view

Pathways & Interactions for ATF5 Gene

genes like me logo Genes that share pathways with ATF5: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ATF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IDA 20654631
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 10373550
GO:0006366 transcription from RNA polymerase II promoter IC --
GO:0007623 circadian rhythm IEA --
GO:0008285 negative regulation of cell proliferation IDA 22528486
genes like me logo Genes that share ontologies with ATF5: view

No data available for SIGNOR curated interactions for ATF5 Gene

Drugs & Compounds for ATF5 Gene

(2) Drugs for ATF5 Gene - From: HMDB and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pseudoephedrine Approved Pharma Target 438
cyclic amp Experimental Pharma 0
genes like me logo Genes that share compounds with ATF5: view

Transcripts for ATF5 Gene

Unigene Clusters for ATF5 Gene

Activating transcription factor 5:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATF5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATF5 Gene

No ASD Table

Relevant External Links for ATF5 Gene

GeneLoc Exon Structure for
ATF5
ECgene alternative splicing isoforms for
ATF5

Expression for ATF5 Gene

mRNA expression in normal human tissues for ATF5 Gene

mRNA differential expression in normal tissues according to GTEx for ATF5 Gene

This gene is overexpressed in Liver (x34.1).

SOURCE GeneReport for Unigene cluster for ATF5 Gene Hs.9754

genes like me logo Genes that share expression patterns with ATF5: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ATF5 Gene

Orthologs for ATF5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ATF5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ATF5 35
  • 84.78 (n)
  • 85.14 (a)
ATF5 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATF5 35
  • 85.13 (n)
  • 82.01 (a)
ATF5 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atf5 35
  • 84.16 (n)
  • 85.46 (a)
Atf5 16
Atf5 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ATF5 35
  • 99.17 (n)
  • 98.94 (a)
ATF5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atf5 35
  • 82.14 (n)
  • 84.29 (a)
lizard
(Anolis carolinensis)
Reptilia ATF5 36
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.511 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15540 35
zebrafish
(Danio rerio)
Actinopterygii wufc14a10 35
atf5a 36
  • 22 (a)
OneToMany
atf5b 36
  • 19 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2402 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2035 36
  • 19 (a)
OneToMany
Species with no ortholog for ATF5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATF5 Gene

ENSEMBL:
Gene Tree for ATF5 (if available)
TreeFam:
Gene Tree for ATF5 (if available)

Paralogs for ATF5 Gene

Paralogs for ATF5 Gene

genes like me logo Genes that share paralogs with ATF5: view

Variants for ATF5 Gene

Sequence variations from dbSNP and Humsavar for ATF5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs8647 -- 49,933,723(+) AAGGC(A/G)GCCAG utr-variant-3-prime
rs283527 -- 49,934,301(+) ctcac(A/G)cctgt downstream-variant-500B
rs7247653 -- 49,934,202(+) tctat(C/T)gcact downstream-variant-500B
rs8101009 -- 49,934,271(+) GGGGG(A/G)GGTGG downstream-variant-500B
rs8101308 -- 49,934,262(+) aaaaa(A/G)GGGGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ATF5 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
dgv53n68 CNV Loss 17160897
dgv54n68 CNV Loss 17160897
nsv458720 CNV Gain 19166990
nsv7309 OTHER Inversion 18451855

Variation tolerance for ATF5 Gene

Residual Variation Intolerance Score: 77.72% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.83; 47.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATF5 Gene

HapMap Linkage Disequilibrium report
ATF5
Human Gene Mutation Database (HGMD)
ATF5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATF5 Gene

Disorders for ATF5 Gene

Relevant External Links for ATF5

Genetic Association Database (GAD)
ATF5
Human Genome Epidemiology (HuGE) Navigator
ATF5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATF5
genes like me logo Genes that share disorders with ATF5: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATF5 Gene

Publications for ATF5 Gene

  1. A genome-wide RNA interference screen reveals an essential CREB3L2-ATF5-MCL1 survival pathway in malignant glioma with therapeutic implications. (PMID: 20495567) Sheng Z. … Green M.R. (Nat. Med. 2010) 23 67
  2. Fasting induced up-regulation of activating transcription factor 5 in mouse liver. (PMID: 19376136) Shimizu Y.I. … Takahashi Y. (Life Sci. 2009) 23 67
  3. Effects of disulfide bond formation and protein helicity on the aggregation of activating transcription factor 5. (PMID: 19435374) Ciaccio N.A. … Laurence J.S. (Mol. Pharm. 2009) 23 67
  4. Identification of a novel DNA binding site and a transcriptional target for activating transcription factor 5 in c6 glioma and mcf-7 breast cancer cells. (PMID: 19531563) Li G. … Liu D.X. (Mol. Cancer Res. 2009) 23 67
  5. High-yield expression in E. coli and refolding of the bZIP domain of activating transcription factor 5. (PMID: 18718539) Ciaccio N.A. … Laurence J.S. (Protein Expr. Purif. 2008) 23 67

Products for ATF5 Gene

Sources for ATF5 Gene

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