Aliases for ATF4 Gene
- Activating Transcription Factor 4 2 3 4
- Tax-Responsive Enhancer Element-Binding Protein 67 3 4
- Cyclic AMP-Responsive Element-Binding Protein 2 3 4
- CAMP-Responsive Element-Binding Protein 2 3 4
- CAMP-Dependent Transcription Factor ATF-4 3 4
- Tax-Responsive Enhancer Element B67 2 3
- DNA-Binding Protein TAXREB67 3 4
External Ids for ATF4 Gene
Previous HGNC Symbols for ATF4 Gene
Previous GeneCards Identifiers for ATF4 Gene
This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011]
GeneCards Summary for ATF4 Gene
ATF4 (Activating Transcription Factor 4) is a Protein Coding gene. Diseases associated with ATF4 include leukoencephalopathy with vanishing white matter and t-cell leukemia. Among its related pathways are PI3K-Akt signaling pathway and MAPK signaling pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is ATF5.
UniProtKB/Swiss-Prot for ATF4 Gene
Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5-GTGACGT[AC][AG]-3), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes.