Aliases for ATF4 Gene
- Activating Transcription Factor 4 2 3 4 5
- Tax-Responsive Enhancer Element-Binding Protein 67 3 4
- Cyclic AMP-Responsive Element-Binding Protein 2 3 4
- CAMP-Responsive Element-Binding Protein 2 3 4
- CAMP-Dependent Transcription Factor ATF-4 3 4
- Tax-Responsive Enhancer Element B67 2 3
- DNA-Binding Protein TAXREB67 3 4
External Ids for ATF4 Gene
Previous HGNC Symbols for ATF4 Gene
Previous GeneCards Identifiers for ATF4 Gene
This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011]
GeneCards Summary for ATF4 Gene
ATF4 (Activating Transcription Factor 4) is a Protein Coding gene. Diseases associated with ATF4 include T-Cell Leukemia. Among its related pathways are HTLV-I infection and Neuropathic Pain-Signaling in Dorsal Horn Neurons. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is ATF5.
UniProtKB/Swiss-Prot for ATF4 Gene
Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5-GTGACGT[AC][AG]-3), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to endoplasmic reticulum (ER) stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. During ER stress response, activates the transcription of NLRP1, possibly in concert with other factors (PubMed:26086088).