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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ATF4 Gene

protein-coding GIFtS: 62
GCID: GC22P039916

activating transcription factor 4 (tax-responsive enhancer...

(Previous symbol: TXREB)

Explore 32 diseases affiliated with
ATF4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67)¹ ²		CAMP-Dependent Transcription Factor ATF-4² ³
CREB-2¹ ² ³		CAMP-Responsive Element-Binding Protein 2² ³
TXREB¹ ² ³		DNA-Binding Protein TAXREB67² ³
TAXREB67¹ ² ⁵		CAMP Response Element-Binding Protein 2²
CREB2² ³ ⁵		Cyclic AMP-Dependent Transcription Factor ATF-4²
Cyclic AMP-Responsive Element-Binding Protein 2² ³		TaxREB67³
Tax-Responsive Enhancer Element-Binding Protein 67² ³		Activating Transcription Factor 4³

External Ids:	HGNC: 786¹	Entrez Gene: 468²	Ensembl: ENSG00000128272⁷	OMIM: 604064⁵	UniProtKB: P18848³

Export aliases for ATF4 gene to outside databases

Previous GC identifers: GC22P036531 GC22P038158 GC22P038159 GC22P038241 GC22P022881

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ATF4:

This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding

protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated

and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to

a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding

proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in

protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding

domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the

X chromosome at q28 in a region containing a large inverted duplication. (provided by RefSeq, Sep 2011)

UniProtKB/Swiss-Prot: ATF4_HUMAN, P18848

Function: Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a

sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose

homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds

to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and

asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of

TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA

Gene Wiki entry for ATF4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000022.10 NC_018933.1 NT_011520.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ATF4 gene promoter:
CREB C/EBPbeta AP-1 ATF-2 deltaCREB ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ATF4 promoter sequence

Search SABiosciences Chromatin IP Primers for ATF4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATF4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1 Ensembl cytogenetic band: 22q13.1 HGNC cytogenetic band: 22q13.1

ATF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATF4 gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22P039916: view genomic region (about GC identifiers)

Start:	39,915,700 bp from pter	End:	39,918,691 bp from pter
Size:	2,992 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ATF4_HUMAN, P18848 (See protein sequence)

Recommended Name: Cyclic AMP-dependent transcription factor ATF-4

Size: 351 amino acids; 38590 Da

Subunit: Binds DNA as a homo- or heterodimer. Interacts (via its leucine zipper domain) with GABBR1 and GABBR2 (via

their C-termini). Interacts (via its DNA binding domain) with FOXO1 (C-terminal half); the interaction occurs in

osteoblasts and regulates glucose homeostasis through suppression of beta-cell proliferation and a decrease in insulin

production. Interacts with SATB2; the interaction results in enhanced DNA binding and transactivation by these

transcription factors (By similarity). Interacts with CEP290 (via an N-terminal region). Interacts with NEK6, DAPK2

(isoform 2) and ZIPK/DAPK3. Forms a heterodimer with TXLNG in osteoblasts. Interacts with DDIT3/CHOP

Subcellular location: Cytoplasm. Cell membrane. Nucleus. Cytoplasm, cytoskeleton, centrosome. Note=Colocalizes with

GABBR1 in hippocampal neuron dendritic membranes (By similarity). Co-localizes with NEK6 in the centrosome

1 PDB 3D structure from and Proteopedia for ATF4:

1CI6 (3D)

Secondary accessions: Q9UH31

Explore the universe of human proteins at neXtProt for ATF4: NX_P18848

Post-translational modifications:

Phosphorylated by NEK6¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P18848

ATF4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001666.2 NP_877962.1

ENSEMBL proteins:

ENSP00000384587 ENSP00000336790 ENSP00000379912

Reactome Protein details: P18848
Human Recombinant Protein Products:

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Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	ISS	--
GO:0005654	nucleoplasm	TAS	--
GO:0005667	transcription factor complex	IEA	--
GO:0005737	cytoplasm	ISS	--
GO:0005815	microtubule organizing center	IEA	--

ATF4 for ontologies About GeneDecksing

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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ATF4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ATF4 for domains About GeneDecksing

1 InterPro domain/family:

IPR004827 bZIP

Graphical View of Domain Structure for InterPro Entry P18848

ProtoNet protein and cluster: P18848

1 Blocks protein family: IPB011616 bZIP transcription factor

UniProtKB/Swiss-Prot: ATF4_HUMAN, P18848

Similarity: Belongs to the bZIP family

Similarity: Contains 1 bZIP (basic-leucine zipper) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ATF4_HUMAN, P18848

Function: Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a

sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose

homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds

to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and

asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of

TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA

Genatlas biochemistry entry for ATF4:

activation transcription factor 4,cAMP dependent,for a tax responsive enhancer element B67 in the long terminal repeat

of human T cell leukemia virus type I

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATF4

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	ISS	--
GO:0003700	sequence-specific DNA binding transcription factor activity	TAS	12689582
GO:0005515	protein binding	IPI	12812986
GO:0008022	protein C-terminus binding	IEA	--
GO:0043565	sequence-specific DNA binding	IEA	--

ATF4 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for ATF4:

Increased cell death HMECs cel

Animal Models:
Mouse knock-outs for ATF4: Atf4^tm1Tow Atf4^tm1Jml Atf4^tm1Aki
14 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Atf4):

adipose tissue	cellular	craniofacial	digestive/alimentary	endocrine/exocrine gland
growth/size	hematopoietic system	homeostasis/metabolism	integument	liver/biliary system
mortality/aging	reproductive system	skeleton	vision/eye

ATF4 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/48 super-pathways (see all 48) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Activation of cAMP-Dependent PKA

	Activation of cAMP-Dependent PKA	1.00			Activation of PKA through GPCR	0.71
	cAMP Pathway	0.77			PKA Signaling	0.56

CREB Pathway

	CREB Pathway	1.00			Activation of PKC through GPCR	0.63
	IP3 Pathway	0.68			Intracellular Calcium Signaling	0.50

GPCR Pathway

	GPCR Pathway	1.00			P2Y Receptor Signaling	0.38
	Estrogen Pathway	0.55

Rho Family GTPases

	ERK Signaling	0.61			ILK Signaling	0.45
	MAPK Signaling	0.51

G-Beta Gamma Signaling

	GHRH Signaling	0.46			Relaxin Pathway	0.32
	CRHR Pathway	0.44

Pathway sources
See GeneCards unified pathways
Show all pathways

1 R&D Systems Pathway for ATF4

TGF-beta Signaling Pathways

5/53 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ATF4 (see all 53)

	FLT3 Signaling
	Nuclear Receptor Activation by Vitamin-A
	Toll-Like Receptors Pathway
	Interferon Pathway
	Intracellular Calcium Signaling

1 Cell Signaling Technology (CST) Pathway for ATF4

Glucose / Energy Metabolism

2 BioSystems Pathways for ATF4

	MAPK signaling pathway
	Myometrial Relaxation and Contraction Pathways

4 Reactome Pathways for ATF4

	PERK regulated gene expression
	Translation and translocation of ATF4
	Metabolism of proteins
	Unfolded Protein Response

5/7 Kegg Pathways (Kegg details for ATF4) (see all 7):

	MAPK signaling pathway
	Protein processing in endoplasmic reticulum
	Long-term potentiation
	Neurotrophin signaling pathway
	Cholinergic synapse

ATF4 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ATF4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/102 Interacting proteins for ATF4 (P18848^{1, 2, 3} ENSP00000336790⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 102)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
POLR2C	P19387²^,³, ENSP00000219252⁴	MINT-49646 MINT-49647 MINT-49645 MINT-49644 MINT-49643 I2D: score=4 STRING: ENSP00000219252
CREBZF	Q9NS37²^,³, ENSP00000260058⁴	MINT-73538 MINT-73537 MINT-73540 MINT-73535 MINT-73539 I2D: score=2 STRING: ENSP00000260058
TRIB3	Q96RU7¹^,³, ENSP00000217233⁴	EBI-492498,EBI-492476 I2D: score=6 STRING: ENSP00000217233
DISC1	Q9NRI5¹^,³, ENSP00000355596⁴	EBI-492498,EBI-529989 I2D: score=4 STRING: ENSP00000355596
JUN	P05412³, ENSP00000360266⁴	I2D: score=6 STRING: ENSP00000360266

About this table

Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006094	gluconeogenesis	ISS	--
GO:0006355	regulation of transcription, DNA-dependent	ISS	--
GO:0006357	regulation of transcription from RNA polymerase II promoter	--	--
GO:0006366	transcription from RNA polymerase II promoter	ISS	--
GO:0006520	cellular amino acid metabolic process	TAS	12689582

ATF4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ATF4 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ATF4

1 HMDB Compound for ATF4 About this table

Compound	Synonyms	CAS #	PubMed Ids
Cyclic AMP	Cyclic AMP (see all 19)	60-92-4	--

10/31 Novoseek chemical compound relationships for ATF4 gene (see all 31) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tunicamycin	77.5	7	15775988 (2), 19100962 (1), 16931790 (1), 17941056 (1) (see all 5)
leucine	62.1	19	15677469 (3), 11018027 (2), 15663480 (1), 20392257 (1) (see all 14)
bortezomib	61.5	12	19417138 (4), 20022965 (2), 16846475 (1), 18341633 (1)
amino acid	59.6	14	14630918 (5), 16026328 (2), 16989641 (1), 17276738 (1) (see all 5)
thapsigargin	59.2	7	19100962 (1), 20022965 (1), 15781252 (1), 19561125 (1) (see all 6)
cyclic amp	46.6	9	15663480 (1), 18957537 (1), 17466566 (1), 16343488 (1) (see all 6)
asparagine	45.6	1	17369260 (1)
noxa	41.1	4	20022965 (1), 19164757 (1), 20085765 (1)
celecoxib	38.6	12	17167033 (2), 16205636 (2), 19073601 (1)
palmitate	30.8	8	17395747 (1), 16601139 (1), 18492819 (1), 17268797 (1)

Search CenterWatch for drugs/clinical trials and news about ATF4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ATF4 gene (2 alternative transcripts):

NM_001675.2 NM_182810.1

Unigene Cluster for ATF4:

Activating transcription factor 4 (tax-responsive enhancer element B67)

Hs.496487 [show with all ESTs]

Unigene Representative Sequence: NM_001675

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000404241 ENST00000337304(uc003aya.3) ENST00000396680(uc011aol.1 uc003axz.3)

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATF4

Additional cDNA sequence:

AK057751.1 AK296028.1 BC008090.1 BC011994.1 BC016855.2 BC022088.2 BC024775.1 BC044895.1

BC073754.1 BC073990.1 CR450353.1 CR456384.1 D90209.1 M86842.1

24/55 DOTS entries (see all 55):

DT.91998220 DT.100045356 DT.95344549 DT.100706342 DT.95344559 DT.91699853 DT.100846900 DT.91842913

DT.100866528 DT.120639148 DT.100803506 DT.92000118 DT.91974463 DT.87017151 DT.95219578 DT.120639306

DT.120639096 DT.95344651 DT.100706351 DT.102839308 DT.91795184 DT.91999377 DT.95103057 DT.100855961

24/2626 AceView cDNA sequences (see all 2626):

BC016855 BF915944 CR605268 BQ233080 AI696938 CF541076 AI753132 BG574457

CD674979 BM743808 BQ016147 BX366850 AK057751 BU845659 F21561 BF983870

BQ683469 BX410223 BX410992 CR619870 CR607769 BI063063 BU630351 BX356334

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for ATF4 About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3
SP1:			-
SP2:

ECgene alternative splicing isoforms for ATF4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ATF4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATCCCTCAGT

About this image

ATF4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/21 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 21)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Membranous Facial Bones

Intramembranous Osteoblasts

Selective marker (cell-identifying gene)

Bone

Membranous Facial Bones

Intramembrenous Osteocytes

Bone

Rostral Skull Membranous Bones

Intramembrenous Osteocytes

Bone

Autopod Periosteum

Endochondral Osteoblasts

Bone

Autopod Periosteum

Endochondral Osteocytes

Bone

Caudal Endochondral Bones

Endochondral Osteoblasts

Bone

Caudal Endochondral Bones

Endochondral Osteocytes

Bone

Cervical Vertebrae

Endochondral Osteoblasts

Bone

Endochondral Facial Bones

Endochondral Osteoblasts

Bone

Endochondral Facial Bones

Endochondral Osteocytes

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ATF4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ATF4

SOURCE GeneReport for Unigene cluster: Hs.496487

SABiosciences Expression via Pathway-Focused PCR Arrays including ATF4 (see all 9):

TGFB/BMP Signaling Pathway in human mouse rat

Stress & Toxicity PathwayFinder in human mouse rat

TGFB Signaling Targets in human mouse rat

Neurotoxicity in human mouse rat

Signal Transduction PathwayFinder in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATF4

In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for ATF4 gene from 5/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ATF4¹	activating transcription factor 4 (tax-responsive enhancer more	70.91(n) 65.9(a)		395693 NM_204880.1 NP_990211.1
lizard (Anolis carolinensis)	Reptilia	ATF4⁶	--	60(a)	1 ↔ 1	5(24911810-24913115)
African clawed frog (Xenopus laevis)	Amphibia	MGC68539²	hypothetical protein MGC68539	76.24(n)		BC059971.1
zebrafish (Danio rerio)	Actinopterygii	atf4b1⁶ atf4b2⁶	activating transcription factor 4b2	32(a) 25(a)	1 ↔ many 1 ↔ many	6(217573-220923) 3(24489175-24492060)
fruit fly (Drosophila melanogaster)	Insecta	crc⁶	cryptocephal	15(a)	1 → many	2L(21310866-21319527)

ENSEMBL Gene Tree for ATF4 (if available)
TreeFam Gene Tree for ATF4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for ATF4 gene

ATF5²

ATF4 for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for ATF4
PGOHUM00000242898 PGOHUM00000241613 PGOHUM00000242094

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs112303731^1,2		--	39914646(+)	`ACTTCC/TGTATA`	2	--	us2k¹		1		CSA	2
rs140698880^1,2		--	39914649(+)	`TCTGTA/GTATCT`	2	--	us2k¹		0	--	--	--	--
rs36059872^1,2	C,	--	39914792(+)	`CAGGAC/GGATGT`	2	--	us2k¹		0	--	--	--	--
rs188294982^1,2		--	39915127(+)	`CCATTA/GGGCCT`	2	--	us2k¹		0	--	--	--	--
rs113910998^1,2		--	39915213(+)	`GCTTCG/CCTGGT`	2	--	us2k¹		1		CSA	2
rs111937889^1,2		--	39915229(+)	`GATATC/AACAGC`	2	--	us2k¹		1		CSA	2
rs78742369^1,2	F,	--	39915258(+)	`CAGTGA/TAATGG`	2	--	us2k¹		1		WA	118
rs142762810^1,2		--	39915419(+)	`CCTGGA/GCCATG`	2	--	us2k¹		0	--	--	--	--
rs140258583^1,2	C,	--	39915826(+)	`CCGCA-/GGGCCA`	2	--	us2k¹		0	--	--	--	--
rs59161709^1,2	C,	--	39916037(+)	`AGCAGC/AGACCC`	2	--	us2k¹		4		WA CSA	123

HapMap Linkage Disequilibrium report for ATF4 (39915700 - 39918691 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ATF4: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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ATF4 for disorders           About GeneDecksing

OMIM gene information: 604064    OMIM disorders: --

20/32 diseases for ATF4 (see all 32):    About MalaCards

coffin-lowry syndrome human t-cell leukemia virus type 1 adenomatous polyposis coli idiopathic pulmonary fibrosis

joubert syndrome pulmonary fibrosis hepatitis e neuroectodermal tumors

anoxia bipolar disorder polyposis t-cell leukemia

hepatitis c fibrosis hypoglycemia pancreatic cancer

hepatitis b breast cancer ischemia hepatitis

7 Novoseek disease relationships for ATF4 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia t-cell	53.7	2	12202230 (1), 16458341 (1)
cancer	31.8	11	17297441 (2), 17466566 (2), 10667576 (1), 14604972 (1) (see all 6)
tumors	17.9	18	19519398 (2), 16148948 (1), 18829529 (1)
pancreatic cancer	9.09	1	17409444 (1)
ischemia	0	1	18082969 (1)
shock	0	2	15081838 (1), 16846475 (1)
breast cancer	0	3	19417138 (2)

Human Genome Epidemiology (HuGE) Navigator: ATF4 (6 documents)

Export disorders for ATF4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ATF4 gene, integrated from 9 sources (see all 284):
(articles sorted by number of sources associating them with ATF4)

Utopia: connect your pdf to the dynamic
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Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element. (PubMed id 1534408)^{1, 2, 3} Karpinski B.A....Leiden J.M. (1992)
Isolation of cDNAs for DNA-binding proteins which specifically bind to a tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I. (PubMed id 1847461)^{1, 2, 3} Tsujimoto A.... Shimotohno K. (1991)
Crystal structure of the CCAAT box/enhancer-binding protein beta activating transcription factor-4 basic leucine zipper heterodimer in the absence of DNA. (PubMed id 11018027)^{1, 2, 9} Podust L.M.... Kim Y. (2001)
TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death. (PubMed id 15775988)^{1, 2, 9} Ohoka N....Hayashi H. (2005)
C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene. (PubMed id 18940792)^{1, 2} Su N. and Kilberg M.S. (2008)
The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4. (PubMed id 16682973)^{1, 2} Sayer J.A.... Hildebrandt F. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence of human chromosome 22. (PubMed id 10591208)^{1, 2} Dunham I....O'Brien K.P. (1999)
Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers. (PubMed id 2516827)^{1, 2} Hai T.... Green M.R. (1989)
TRB3 protects cells against the growth inhibitory and cytotoxic effect of ATF4. (PubMed id 17707795)^{1, 9} Ord D....Ord T. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 468	HGNC: 786	AceView: ATF4andFLJ20232	Ensembl:ENSG00000128272	euGenes: HUgn468
ECgene: ATF4	Kegg: 468	H-InvDB: ATF4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ATF4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ATF4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ATF4 gene:
Search GeneIP for patents involving ATF4

GeneCards and IP:
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