Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ATF3 Gene

protein-coding   GIFtS: 65
GCID: GC01P212738

Activating Transcription Factor 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Activating Transcription Factor 31 2 3
CAMP-Dependent Transcription Factor ATF-32 3
Cyclic AMP-Dependent Transcription Factor ATF-32

External Ids:    HGNC: 7851   Entrez Gene: 4672   Ensembl: ENSG000001627727   OMIM: 6031485   UniProtKB: P188473   

Export aliases for ATF3 gene to outside databases

Previous GC identifers: GC01P211461 GC01P208625 GC01P209398 GC01P209838 GC01P209170 GC01P210805 GC01P183415


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ATF3 Gene:
This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB)
protein family of transcription factors. This gene is induced by a variety of signals, including many of those
encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple
transcript variants encoding different isoforms have been found for this gene. It is possible that alternative
splicing of this gene may be physiologically important in the regulation of target genes. (provided by RefSeq,
Apr 2011)

GeneCards Summary for ATF3 Gene:
ATF3 (activating transcription factor 3) is a protein-coding gene. Diseases associated with ATF3 include hypospadias, and erythema multiforme. GO annotations related to this gene include identical protein binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is JDP2.

UniProtKB/Swiss-Prot: ATF3_HUMAN, P18847
Function: This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence
present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may
repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates
transcription presumably by sequestering inhibitory cofactors away from the promoters

Gene Wiki entry for ATF3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ATF3 gene promoter:
         CREB   deltaCREB   C/EBPalpha   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ATF3 promoter sequence
   Search Chromatin IP Primers for ATF3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.3   Ensembl cytogenetic band:  1q32.3   HGNC cytogenetic band: 1q32.3

ATF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATF3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P212738:  view genomic region     (about GC identifiers)

Start:
212,738,676 bp from pter      End:
212,794,119 bp from pter
Size:
55,444 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ATF3_HUMAN, P18847 (See protein sequence)
Recommended Name: Cyclic AMP-dependent transcription factor ATF-3  
Size: 181 amino acids; 20576 Da
Subunit: Binds DNA as a homodimer or a heterodimer
Secondary accessions: Q5VTZ2 Q6ICQ9 Q7Z566 Q8WYM6
Alternative splicing: 5 isoforms:  P18847-1   P18847-2   P18847-3   P18847-4   P18847-5   (Stress-induced isoform, counteracts the transcriptional repression of isoform 1)

Explore the universe of human proteins at neXtProt for ATF3: NX_P18847

Explore proteomics data for ATF3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ATF3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001025458.1  NP_001035709.1  NP_001193413.2  NP_001193415.1  NP_001193417.2  NP_001665.1  

    ENSEMBL proteins: 
     ENSP00000355948   ENSP00000344352   ENSP00000355952   ENSP00000336908   ENSP00000432208  
     ENSP00000355950   ENSP00000355954  
    Reactome Protein details: P18847

    ATF3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ATF3
    OriGene Protein Over-expression Lysate for ATF3
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ATF3
    GenScript Custom Purified and Recombinant Proteins Services for ATF3
    Novus Biologicals ATF3 Proteins
    Novus Biologicals ATF3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for ATF3
    Cloud-Clone Corp. Proteins for ATF3

    ATF3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ATF3
    OriGene Custom Antibody Services for ATF3
    Novus Biologicals ATF3 Antibodies
    Abcam antibodies for ATF3
    Cloud-Clone Corp. Antibodies for ATF3
    Search ThermoFisher Antibodies for ATF3
    LSBio Antibodies in human, mouse, rat for ATF3

    ATF3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ATF3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ATF3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ATF3
    Cloud-Clone Corp. CLIAs for ATF3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    bZIP: basic leucine zipper proteins

    2 InterPro protein domains:
     IPR004827 bZIP
     IPR000837 Leuzip_Fos

    Graphical View of Domain Structure for InterPro Entry P18847

    ProtoNet protein and cluster: P18847

    1 Blocks protein domain: IPB000837 Fos transforming protein signature

    UniProtKB/Swiss-Prot: ATF3_HUMAN, P18847
    Similarity: Belongs to the bZIP family. ATF subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    ATF3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATF3_HUMAN, P18847
    Function: This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence
    present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may
    repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates
    transcription presumably by sequestering inhibitory cofactors away from the promoters

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003714transcription corepressor activity TAS7515060
    GO:0005515protein binding IPI16291753
    GO:0042802identical protein binding IPI18255255
         
    ATF3 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Atf3):
     endocrine/exocrine gland  hematopoietic system  immune system  respiratory system  tumorigenesis 

    ATF3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Atf3tm1Dron for ATF3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ATF3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ATF3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ATF3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ATF3

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  DATGASTCATHN 

    miRNA
    Products:
        
    miRTarBase miRNAs that target ATF3:
    hsa-mir-26b-5p (MIRT029081), hsa-mir-17-5p (MIRT050819), hsa-mir-331-3p (MIRT043494)

    Block miRNA regulation of human, mouse, rat ATF3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ATF3 (see all 9):
    hsa-miR-600 hsa-miR-3200-5p hsa-miR-27a hsa-miR-513a-5p hsa-miR-218-1* hsa-miR-135b hsa-miR-494 hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidATF3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ATF3
    Predesigned siRNA for gene silencing in human, mouse, rat ATF3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ATF3

    Clone
    Products:
         
    OriGene clones in human, mouse for ATF3 (see all 20)
    OriGene ORF clones in mouse, rat for ATF3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 7): ATF3 (NM_001030287)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATF3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ATF3
    Browse ESI BIO Cell Lines and PureStem Progenitors for ATF3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATF3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ATF3_HUMAN, P18847: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton2
    cytosol2
    endoplasmic reticulum2
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730nucleolus IDA--

    ATF3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ATF3 About   (see all 19)  
    See pathways by source

    SuperPathContained pathways About
    1PERK regulated gene expression
    PERK regulated gene expression0.90
    Activation of Genes by ATF40.90
    2ERK Signaling
    MAPK Signaling0.58
    ILK Signaling0.49
    3Unfolded Protein Response
    Unfolded Protein Response0.61
    4TWEAK Pathway
    TNF Signaling0.55
    5TCR Signaling (Qiagen)
    ITK and TCR Signaling0.54

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ATF3 (see all 8)
        MAPK Signaling
    PI3K Signaling in B-Lymphocyte
    iNOS Signaling
    SMAD Signaling Network
    TNF Signaling

    Selected BioSystems Pathways for ATF3 (see all 7)
        Myometrial Relaxation and Contraction Pathways
    TGF-beta Receptor Signaling Pathway
    Hypertrophy Model
    Id Signaling Pathway
    Direct p53 effectors

    1 Reactome Pathway for ATF3
        ATF4 activates genes

    1 PharmGKB Pathway for ATF3
        Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

    1 Kegg Pathway  (Kegg details for ATF3):
        HTLV-I infection


    ATF3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ATF3: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Nephrotoxicity in human mouse rat
              TGFB Signaling Targets in human mouse rat
              Polycomb & Trithorax Target Genes in human mouse rat
              Transcription Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ATF3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ATF3 (P188471, 2, 3 ENSP000003443524) via UniProtKB, MINT, STRING, and/or I2D (see all 63)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    JUNP054122, 3, ENSP000003602664MINT-6628036 I2D: score=5 STRING: ENSP00000360266
    RELAQ042061, 3, ENSP000003842734EBI-712767,EBI-73886 I2D: score=3 STRING: ENSP00000384273
    FHL2Q141921, 3, ENSP000003229094EBI-712767,EBI-701903 I2D: score=1 STRING: ENSP00000322909
    TP53P046373, ENSP000002693054I2D: score=6 STRING: ENSP00000269305
    JUNDP175353, ENSP000002528184I2D: score=4 STRING: ENSP00000252818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006094gluconeogenesis IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006950response to stress ----
    GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--

    ATF3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ATF3

    1 HMDB Compound for ATF3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    Selected Novoseek inferred chemical compound relationships for ATF3 gene (see all 30)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sulindac sulfide 73.1 9 16079301 (3), 15897233 (2), 19934343 (1), 20130018 (1)
    amino acid 59.7 12 16989641 (4), 17042743 (1), 16026328 (1), 12881527 (1)
    anisomycin 55.1 9 17014422 (2), 8576171 (2), 16394627 (1), 19101521 (1)
    deoxynivalenol 41.5 5 19360757 (2), 19101521 (1), 19591856 (1)
    indole-3-carbinol 39.5 1 15670751 (1)
    leucine 37.9 8 12815047 (1), 12225289 (1), 8152431 (1), 16516039 (1) (see all 5)
    oligonucleotide 34.4 4 10965025 (2), 11589305 (1), 15280448 (1)
    cyclic amp 34.1 14 7935470 (2), 17952119 (1), 8007991 (1), 19705082 (1) (see all 8)
    troglitazone 32.3 4 16079301 (2), 15897233 (1)
    resveratrol 24 2 15897233 (1), 18776171 (1)



    ATF3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ATF3 gene (8 alternative transcripts): 
    NM_001030287.3  NM_001040619.2  NM_001206484.2  NM_001206486.2  NM_001206488.2  NM_001674.3  NM_001206485.1  NM_004024.4  

    Unigene Cluster for ATF3:

    Activating transcription factor 3
    Hs.460  [show with all ESTs]
    Unigene Representative Sequence: NM_001040619
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366981 ENST00000465155(uc001hjj.3) ENST00000341491(uc021pit.1 uc001hjh.3 uc021piu.1 uc001hji.3 uc021piv.1)
    ENST00000366985 ENST00000492118 ENST00000336937 ENST00000464547 ENST00000366983
    ENST00000366987(uc001hjf.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ATF3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ATF3 (see all 9):
    hsa-miR-600 hsa-miR-3200-5p hsa-miR-27a hsa-miR-513a-5p hsa-miR-218-1* hsa-miR-135b hsa-miR-494 hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidATF3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ATF3
    Predesigned siRNA for gene silencing in human, mouse, rat ATF3
    Clone
    Products:
         
    OriGene clones in human, mouse for ATF3 (see all 20)
    OriGene ORF clones in mouse, rat for ATF3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 7): ATF3 (NM_001030287)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATF3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ATF3
    OriGene qSTAR qPCR primer pairs in human, mouse for ATF3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ATF3
      QuantiTect SYBR Green Assays in human, mouse, rat ATF3
      QuantiFast Probe-based Assays in human, mouse, rat ATF3

    Additional mRNA sequence: 

    AB066566.1 AB078026.1 AB078027.1 AB078028.1 AK125255.1 AK312998.1 AY313927.1 BC006322.2 
    BT006996.1 CR450334.1 L19871.1 

    22 DOTS entries:

    DT.216448  DT.95279991  DT.70100962  DT.100029805  DT.99961573  DT.97844923  DT.100887717  DT.95279990 
    DT.70103799  DT.91775485  DT.100887713  DT.121438085  DT.100706708  DT.101981395  DT.100887716  DT.95279988 
    DT.121438139  DT.121438163  DT.95279994  DT.95279995  DT.97844922  DT.95279985 

    Selected AceView cDNA sequences (see all 277):

    CR614684 BM764975 AB078026 CR614862 CB068770 W15409 AU141602 BM773048 
    BF938962 CR619424 AU142098 BF445768 BU752221 AL520149 AB066566 BM742949 
    AI081317 R38597 BF001761 AI800224 AB078027 CB156560 AB078028 CR626784 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ATF3 (see all 11)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b
    SP1:                                -     -                             -                 -     -     -     -     -               
    SP2:                                      -                             -                                                         
    SP3:                                -     -                             -                 -     -                                 
    SP4:                                                        -           -                 -     -                                 
    SP5:                                                                    -                 -     -                                 


    ECgene alternative splicing isoforms for ATF3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ATF3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGCTGTTTT
    ATF3 Expression
    About this image


    ATF3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Neural Ectoderm (Nervous System)
             Neural ectoderm cells
     
     Somite (Muscoskeletal System)
             Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
     
     Testis (Reproductive System)
             Sertoli cells Seminiferous Tubules
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
    ATF3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ATF3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.460
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ATF3: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Nephrotoxicity in human mouse rat
              TGFB Signaling Targets in human mouse rat
              Polycomb & Trithorax Target Genes in human mouse rat
              Transcription Factors in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ATF3
    OriGene qSTAR qPCR primer pairs in human, mouse for ATF3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ATF3
    QuantiTect SYBR Green Assays in human, mouse, rat ATF3
    QuantiFast Probe-based Assays in human, mouse, rat ATF3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATF3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for ATF3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atf31 , 5 activating transcription factor 31, 5 88.95(n)1
    95.03(a)1
      1 (96.28 cM)5
    119101  NM_007498.31  NP_031524.21 
     1911702965 
    chicken
    (Gallus gallus)
    Aves ATF31 activating transcription factor 3 76.06(n)
    85.64(a)
      421369  XM_004935334.1  XP_004935391.1 
    lizard
    (Anolis carolinensis)
    Reptilia ATF36
    activating transcription factor 3
    85(a)
    1 ↔ 1
    1(238611997-238623623)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia atf31 activating transcription factor 3 74.22(n)
    81.22(a)
      100494437  XM_002934698.2  XP_002934744.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc555262 similar to activating transcription factor 3 73.64(n)   393939  BC045371.1 


    ENSEMBL Gene Tree for ATF3 (if available)
    TreeFam Gene Tree for ATF3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ATF3 gene
    JDP22  
    7 SIMAP similar genes for ATF3 using alignment to 3 protein entries:     ATF3_HUMAN (see all proteins):
    FOSB    FOS    FOSL2    FOSL1    BATF3    JDP2
    BATF

    ATF3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ATF3 (see all 1190)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs666450481,2
    C--183417302(+) TTTTCT/-TTTTT 1 -- int11Minor allele frequency- -:0.50NA 2
    rs1427708371,2
    C--183420267(+) CCTCC-/CTAT  
            
    CTATT
    1 -- int10--------
    rs1457739931,2
    C--183422089(+) GTGAT-/CCCGCC 1 -- int10--------
    rs1480496811,2
    C--183424078(+) TAGGG-/TTTTTT 1 -- int10--------
    rs49516141,2
    C,H--183426857(+) CttttC/Tttttt 1 -- int1 trp30--------
    rs711470111,2
    C--183443911(-) AACAC-/TT/TT 
     T
    /TTTTT
    TTTTT
    1 -- int11NA 2
    rs716926761,2
    C--183459526(+) GGGGG-/TGGGGG 5 -- int10--------
    rs559712271,2
    C--183459538(+) GCGCAG/AAGAGG 5 -- int11Minor allele frequency- A:0.50NA 2
    rs1115177061,2
    C--183468121(+) TGTGT-/GTGTGT 6 -- int11Minor allele frequency- G:0.00CSA 2
    rs1113685861,2
    C,F--212737296(+) AGGCCG/AGTCTC 1 -- us2k11Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for ATF3 (212738676 - 212794119 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ATF3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv268560CNV Insertion20981092
    dgv178e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): ATF3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ATF3
    DNA2.0 Custom Variant and Variant Library Synthesis for ATF3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603148    OMIM disorders: --

    Selected diseases for ATF3 (see all 40):    
    About MalaCards
    hypospadias    erythema multiforme    uterine fibroid    anoxia
    obesity, association with    cockayne syndrome    keratitis    adult t-cell leukemia
    wilms tumor    leiomyoma    esophageal squamous cell carcinoma    t-cell leukemia
    lateral sclerosis    amyotrophic lateral sclerosis    obesity    laryngitis
    sepsis    ovarian cancer    insulin resistance    colorectal cancer

    1 disease from the University of Copenhagen DISEASES database for ATF3:
    Hypospadias

    ATF3 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for ATF3 gene (see all 21)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypospadias 59.6 35 18804813 (9), 18426833 (6), 16306208 (4), 18001166 (3) (see all 7)
    tumors 34.3 36 18808719 (3), 17178897 (3), 15674352 (2), 17952119 (2) (see all 17)
    adenovirus infections 28.2 1 16860366 (1)
    colon cancer 23.9 7 10965025 (3), 11341467 (1), 11589305 (1), 19063862 (1) (see all 5)
    cancer 23.3 20 17952119 (3), 19136462 (3), 16628010 (2), 16847457 (1) (see all 9)
    inflammation 20.8 6 18794337 (2), 12161427 (1), 19155971 (1), 18315734 (1) (see all 5)
    colorectal cancer 13.6 9 17964072 (2), 16489044 (2), 15897233 (1), 15670751 (1) (see all 7)
    carcinoma squamous cell 12 3 19423649 (1), 18808719 (1), 11092977 (1)
    leukemia t-cell 10 1 8007991 (1)
    cell damage 9.53 2 16854522 (1)

    Genetic Association Database (GAD): ATF3
    Human Genome Epidemiology (HuGE) Navigator: ATF3 (8 documents)

    Export disorders for ATF3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ATF3 gene, integrated from 10 sources (see all 290):
    (articles sorted by number of sources associating them with ATF3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ATF3 and ATF3 delta Zip. Transcriptional repression versus activation by alternatively spliced isoforms. (PubMed id 7515060)1, 2, 3, 9 Chen B.P.C.... Hai T. (J. Biol. Chem. 1994)
    2. Activating transcription factor 3: a hormone responsive gene in the etiology of hypospadias. (PubMed id 18426833)1, 4, 9 Beleza-Meireles A....NordenskjAPld A. (Eur. J. Endocrinol. 2008)
    3. Amino acid deprivation and endoplasmic reticulum stress induce expression of multiple activating transcription factor-3 mRNA species that, when overexpressed in HepG2 cells, modulate transcription by the human asparagine synthetase promoter. (PubMed id 12881527)1, 2, 9 Pan Y.... Kilberg M.S. (J. Biol. Chem. 2003)
    4. Genetics of hypospadias: are single-nucleotide polymorphisms in SRD5A2, ESR1, ESR2, and ATF3 really associated with the malformation? (PubMed id 20215396)1, 4, 9 van der Zanden L.F....Franke B. (J. Clin. Endocrinol. Metab. 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (Genome Biol. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. An alternatively spliced isoform of transcriptional repressor ATF3 and its induction by stress stimuli. (PubMed id 12034827)1, 2 Hashimoto Y.... Kitajima S. (Nucleic Acids Res. 2002)
    10. Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers. (PubMed id 2516827)1, 2 Hai T.... Green M.R. (Genes Dev. 1989)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 467 HGNC: 785 AceView: ATF3 Ensembl:ENSG00000162772 euGenes: HUgn467
    ECgene: ATF3 Kegg: 467 H-InvDB: ATF3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ATF3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ATF3 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/atf3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ATF3 gene:
    Search GeneIP for patents involving ATF3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ATF3   OriGene RNAi products in human, mouse, rat for ATF3  
     OriGene qPCR primer pairs and template standards for ATF3   OriGene Protein Over-expression Lysate for ATF3  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ATF3  
     OriGene qSTAR qPCR primer pairs in human, mouse for ATF3   OriGene Purified Protein for ATF3  
     OriGene ORF clones in mouse, rat for ATF3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ATF3   OriGene Custom Protein Services for ATF3  

     
     
     Block miRNA regulation of human, mouse, rat ATF3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ATF3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATF3 Predesigned siRNA for gene silencing in human, mouse, rat ATF3
     QuantiFast Probe-based Assays in human, mouse, rat ATF3 QuantiTect SYBR Green Assays in human, mouse, rat ATF3
     PCR Arrays including human, mouse, rat ATF3 Search Chromatin IP Primers for ATF3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ATF3  GeneGlobe Interaction Network for ATF3
     Regulatory tfbs in ATF3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ATF3 GenScript cDNA clones with any tag delivered in your preferred vector for ATF3
     GenScript Custom Assay Services for ATF3 GenScript Custom overexpressing Cell Line Services for ATF3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ATF3
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ATF3 antibodies
     ATF3 proteins
     ATF3 lysates
     Antibodies for ATF3
     See all of Abcam's Antibodies, Kits and Proteins for ATF3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for ATF3
     Proteins for ATF3
     Antibodies for ATF3
     ELISAs for ATF3
     CLIAs for ATF3



     Browse ESI BIO Cell Lines and PureStem Progenitors for ATF3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATF3
     SwitchGear 3'UTR luciferase reporter plasmids for ATF3
     SwitchGear Promoter luciferase reporter plasmids for ATF3
     Search ThermoFisher Antibodies for ATF3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATF3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ATF3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ATF3
     LSBio Antibodies in human, mouse, rat for ATF3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ATF3 gene at Home site.
    Version: 3.12.162 20 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4