Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ATF3 Gene

Aliases for ATF3 Gene

  • Activating Transcription Factor 3 2 3 4 5
  • CAMP-Dependent Transcription Factor ATF-3 4

External Ids for ATF3 Gene

Previous GeneCards Identifiers for ATF3 Gene

  • GC01P211461
  • GC01P208625
  • GC01P209398
  • GC01P209838
  • GC01P209170
  • GC01P210805
  • GC01P212738
  • GC01P183415

Summaries for ATF3 Gene

Entrez Gene Summary for ATF3 Gene

  • This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011]

GeneCards Summary for ATF3 Gene

ATF3 (Activating Transcription Factor 3) is a Protein Coding gene. Diseases associated with ATF3 include Hypospadias and Bone Cancer. Among its related pathways are TNFR1 Pathway and Tacrolimus/Cyclosporine Pathway, Pharmacodynamics. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is JDP2.

UniProtKB/Swiss-Prot for ATF3 Gene

  • This protein binds the cAMP response element (CRE) (consensus: 5-GTGACGT[AC][AG]-3), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.

Gene Wiki entry for ATF3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATF3 Gene

Genomics for ATF3 Gene

Regulatory Elements for ATF3 Gene

Enhancers for ATF3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G212481 2 FANTOM5 Ensembl ENCODE dbSUPER 39.1 -79.4 -79418 8.2 PKNOX1 FOXA2 ARNT SIN3A FEZF1 ZNF2 ZNF766 FOS DEK SP3 LOC105372907 ATF3 ANGEL2 BATF3 LOC105372908
GH01G212490 2 FANTOM5 Ensembl ENCODE dbSUPER 38.8 -73.9 -73935 1.3 HDGF ARID4B SIN3A ZNF2 ZNF143 ZNF207 ZNF548 ZNF263 SP3 REST LOC105372907 ATF3 BATF3 LOC105372908
GH01G212531 1.5 VISTA FANTOM5 ENCODE 34.6 -32.7 -32657 2.5 ATF1 L3MBTL2 RNF2 MAFG GABPA FOSL1 ZNF589 IRF1 FOXJ2 NFE2 ATF3 BATF3 LOC105372907 LINC01740 LOC105372908
GH01G212476 1.8 FANTOM5 Ensembl ENCODE dbSUPER 27.7 -87.6 -87562 1.7 PKNOX1 ATF1 WRNIP1 BRCA1 YY1 ZNF766 GATA2 ELK1 ZNF143 KLF13 LOC105372907 ATF3 NENF FAM71A ENSG00000235862 BATF3 TMEM206 ENSG00000212187 VASH2 LOC105372908
GH01G212594 2 FANTOM5 Ensembl ENCODE dbSUPER 19.1 +31.1 31123 3.3 PKNOX1 FOXA2 ARNT WRNIP1 FEZF1 ZNF2 YY1 CBX5 ZNF143 ZNF207 ATF3 FAM71A ENSG00000235862 BATF3 ANGEL2 TMEM206 PPP2R5A GC01M212615
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ATF3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ATF3 Gene

Chromosome:
1
Start:
212,565,334 bp from pter
End:
212,620,777 bp from pter
Size:
55,444 bases
Orientation:
Plus strand

Genomic View for ATF3 Gene

Genes around ATF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATF3 Gene

Proteins for ATF3 Gene

  • Protein details for ATF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18847-ATF3_HUMAN
    Recommended name:
    Cyclic AMP-dependent transcription factor ATF-3
    Protein Accession:
    P18847
    Secondary Accessions:
    • Q5VTZ2
    • Q6ICQ9
    • Q7Z566
    • Q8WYM6

    Protein attributes for ATF3 Gene

    Size:
    181 amino acids
    Molecular mass:
    20576 Da
    Quaternary structure:
    • Binds DNA as a homodimer or a heterodimer.

    Alternative splice isoforms for ATF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATF3 Gene

Post-translational modifications for ATF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ATF3 (ATF-3)
  • Abcam antibodies for ATF3

No data available for DME Specific Peptides for ATF3 Gene

Domains & Families for ATF3 Gene

Gene Families for ATF3 Gene

Protein Domains for ATF3 Gene

Graphical View of Domain Structure for InterPro Entry

P18847

UniProtKB/Swiss-Prot:

ATF3_HUMAN :
  • Belongs to the bZIP family. ATF subfamily.
Family:
  • Belongs to the bZIP family. ATF subfamily.
genes like me logo Genes that share domains with ATF3: view

Function for ATF3 Gene

Molecular function for ATF3 Gene

UniProtKB/Swiss-Prot Function:
This protein binds the cAMP response element (CRE) (consensus: 5-GTGACGT[AC][AG]-3), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.

Gene Ontology (GO) - Molecular Function for ATF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IDA 24939851
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 2516827
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IC --
genes like me logo Genes that share ontologies with ATF3: view
genes like me logo Genes that share phenotypes with ATF3: view

Animal Models for ATF3 Gene

MGI Knock Outs for ATF3:

Animal Model Products

Targeted motifs for ATF3 Gene
HOMER Transcription Factor Regulatory Elements motif ATF3
  • Consensus sequence: DATGASTCATHN Submotif: canonical Cell Type: GBM GEO ID: GSE33912

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for ATF3 Gene

Localization for ATF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATF3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATF3 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for ATF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 8622660
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:1990622 CHOP-ATF3 complex IDA 8622660
genes like me logo Genes that share ontologies with ATF3: view

Pathways & Interactions for ATF3 Gene

genes like me logo Genes that share pathways with ATF3: view

SIGNOR curated interactions for ATF3 Gene

Activates:

Gene Ontology (GO) - Biological Process for ATF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 8622660
GO:0006094 gluconeogenesis IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with ATF3: view

Drugs & Compounds for ATF3 Gene

(19) Drugs for ATF3 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pseudoephedrine Approved Pharma Target 628
cyclic amp Experimental Pharma 0

(12) Additional Compounds for ATF3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ATF3: view

Transcripts for ATF3 Gene

Unigene Clusters for ATF3 Gene

Activating transcription factor 3:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATF3 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b
SP1: - - - - - - - -
SP2: - -
SP3: - - - - -
SP4: - - - -
SP5: - - -
SP6: - - - - - - -
SP7: - - -
SP8: - -
SP9: -
SP10: - - -
SP11: -

Relevant External Links for ATF3 Gene

GeneLoc Exon Structure for
ATF3
ECgene alternative splicing isoforms for
ATF3

Expression for ATF3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ATF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ATF3 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ATF3 Gene



Protein tissue co-expression partners for ATF3 Gene

NURSA nuclear receptor signaling pathways regulating expression of ATF3 Gene:

ATF3

SOURCE GeneReport for Unigene cluster for ATF3 Gene:

Hs.460

Evidence on tissue expression from TISSUES for ATF3 Gene

  • Nervous system(4.7)
  • Lung(4.6)
  • Muscle(4.5)
  • Liver(2.9)
  • Heart(2.6)
  • Intestine(2.5)
  • Kidney(2.5)
  • Pancreas(2.3)
  • Adrenal gland(2.1)
  • Blood(2)
genes like me logo Genes that share expression patterns with ATF3: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATF3 Gene

Orthologs for ATF3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ATF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATF3 34 35
  • 99.63 (n)
cow
(Bos Taurus)
Mammalia ATF3 34 35
  • 93.74 (n)
dog
(Canis familiaris)
Mammalia ATF3 34 35
  • 93.37 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ATF3 35
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATF3 35
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atf3 34 16 35
  • 88.95 (n)
rat
(Rattus norvegicus)
Mammalia Atf3 34
  • 88.03 (n)
chicken
(Gallus gallus)
Aves ATF3 34 35
  • 76.06 (n)
lizard
(Anolis carolinensis)
Reptilia ATF3 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atf3 34
  • 74.22 (n)
zebrafish
(Danio rerio)
Actinopterygii atf3 34 35
  • 67.8 (n)
zgc55526 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 27 (a)
OneToMany
Species where no ortholog for ATF3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATF3 Gene

ENSEMBL:
Gene Tree for ATF3 (if available)
TreeFam:
Gene Tree for ATF3 (if available)

Paralogs for ATF3 Gene

Paralogs for ATF3 Gene

(7) SIMAP similar genes for ATF3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ATF3: view

Variants for ATF3 Gene

Sequence variations from dbSNP and Humsavar for ATF3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000007038 -- 212,615,933(+) CACAG(A/G)GATGA intron-variant
rs1000014351 -- 212,593,132(+) CATGT(A/C)CTTTG intron-variant
rs1000073434 -- 212,606,402(+) TGAAG(C/T)AAGAT intron-variant, upstream-variant-2KB
rs1000087672 -- 212,566,721(+) AAAGT(A/G)TCTGA intron-variant
rs1000171183 -- 212,596,739(+) ACATG(A/G)ATGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATF3 Gene

Variant ID Type Subtype PubMed ID
esv2758996 CNV loss 17122850
esv3394920 CNV insertion 20981092
nsv549139 CNV gain 21841781

Variation tolerance for ATF3 Gene

Residual Variation Intolerance Score: 63.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.01; 20.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATF3 Gene

Human Gene Mutation Database (HGMD)
ATF3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATF3 Gene

Disorders for ATF3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ATF3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hypospadias
  • familial hypospadias
bone cancer
  • bone neoplasm
pharyngoconjunctival fever
  • adenoviral pharyngoconjunctivitis
- elite association - COSMIC cancer census association via MalaCards
Search ATF3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ATF3

Genetic Association Database (GAD)
ATF3
Human Genome Epidemiology (HuGE) Navigator
ATF3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATF3
genes like me logo Genes that share disorders with ATF3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ATF3 Gene

Publications for ATF3 Gene

  1. ATF3 and ATF3 delta Zip. Transcriptional repression versus activation by alternatively spliced isoforms. (PMID: 7515060) Chen B.P.C. … Hai T. (J. Biol. Chem. 1994) 2 3 4 22 64
  2. Genetics of hypospadias: are single-nucleotide polymorphisms in SRD5A2, ESR1, ESR2, and ATF3 really associated with the malformation? (PMID: 20215396) van der Zanden L.F. … Franke B. (J. Clin. Endocrinol. Metab. 2010) 3 22 46 64
  3. Activating transcription factor 3: a hormone responsive gene in the etiology of hypospadias. (PMID: 18426833) Beleza-Meireles A. … NordenskjAPld A. (Eur. J. Endocrinol. 2008) 3 22 46 64
  4. Amino acid deprivation and endoplasmic reticulum stress induce expression of multiple activating transcription factor-3 mRNA species that, when overexpressed in HepG2 cells, modulate transcription by the human asparagine synthetase promoter. (PMID: 12881527) Pan Y. … Kilberg M.S. (J. Biol. Chem. 2003) 3 4 22 64
  5. NSAID-activated gene-1 as a molecular target for capsaicin-induced apoptosis through a novel molecular mechanism involving GSK3beta, C/EBPbeta and ATF3. (PMID: 20110283) Lee S.H. … Baek S.J. (Carcinogenesis 2010) 3 22 64

Products for ATF3 Gene

  • Addgene plasmids for ATF3

Sources for ATF3 Gene

Content
Loading form....