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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ATF3 Gene

protein-coding GIFtS: 62
GCID: GC01P212738

activating transcription factor 3

Explore 41 diseases affiliated with
ATF3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Activating Transcription Factor 3¹ ² ³
CAMP-Dependent Transcription Factor ATF-3² ³
Cyclic AMP-Dependent Transcription Factor ATF-3²

External Ids:	HGNC: 785¹	Entrez Gene: 467²	Ensembl: ENSG00000162772⁷	OMIM: 603148⁵	UniProtKB: P18847³

Export aliases for ATF3 gene to outside databases

Previous GC identifers: GC01P211461 GC01P208625 GC01P209398 GC01P209838 GC01P209170 GC01P210805 GC01P183415

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ATF3:

This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB)

protein family of transcription factors. This gene is induced by a variety of signals, including many of those

encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript

variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this

gene may be physiologically important in the regulation of target genes. (provided by RefSeq, Apr 2011)

UniProtKB/Swiss-Prot: ATF3_HUMAN, P18847

Function: This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in

many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription

by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by

sequestering inhibitory cofactors away from the promoters

Gene Wiki entry for ATF3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_167186.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ATF3 gene promoter:
CREB deltaCREB C/EBPalpha ATF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ATF3 promoter sequence

Search SABiosciences Chromatin IP Primers for ATF3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATF3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.3 Ensembl cytogenetic band: 1q32.3 HGNC cytogenetic band: 1q32.3

ATF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATF3 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P212738: view genomic region (about GC identifiers)

Start:	212,738,676 bp from pter	End:	212,794,119 bp from pter
Size:	55,444 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ATF3_HUMAN, P18847 (See protein sequence)

Recommended Name: Cyclic AMP-dependent transcription factor ATF-3

Size: 181 amino acids; 20576 Da

Subunit: Binds DNA as a homodimer or a heterodimer

Subcellular location: Nucleus

Secondary accessions: Q6ICQ9 Q7Z566 Q8WYM6

Alternative splicing: 4 isoforms: P18847-1 P18847-2 P18847-3 P18847-4 (Stress-induced isoform, counteracts the transcriptional repression of isoform 1)

Explore the universe of human proteins at neXtProt for ATF3: NX_P18847

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P18847

ATF3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (6 alternative transcripts):

NP_001025458.1 NP_001035709.1 NP_001193413.2 NP_001193415.1 NP_001193417.2 NP_001665.1

ENSEMBL proteins:

ENSP00000355948 ENSP00000344352 ENSP00000355952 ENSP00000432208 ENSP00000355950

ENSP00000336908 ENSP00000355954

Reactome Protein details: P18847
Human Recombinant Protein Products for ATF3:

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	Uscn Proteins for ATF3

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005730	nucleolus	IDA	--

ATF3 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for ATF3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ATF3 for domains About GeneDecksing

2 InterPro domains/families:

IPR004827 bZIP

IPR000837 Leuzip_Fos

Graphical View of Domain Structure for InterPro Entry P18847

ProtoNet protein and cluster: P18847

1 Blocks protein family: IPB000837 Fos transforming protein signature

UniProtKB/Swiss-Prot: ATF3_HUMAN, P18847

Similarity: Belongs to the bZIP family. ATF subfamily

Similarity: Contains 1 bZIP (basic-leucine zipper) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ATF3_HUMAN, P18847

Function: This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in

many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription

by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by

sequestering inhibitory cofactors away from the promoters

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	--	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0003714	transcription corepressor activity	TAS	7515060
GO:0005515	protein binding	IPI	18255255
GO:0042802	identical protein binding	IPI	18255255

ATF3 for ontologies About GeneDecksing

Phenotypes:
3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Atf3):

endocrine/exocrine gland

immune system

respiratory system

ATF3 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Atf3^tm1Dron for ATF3

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ATF3

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATF3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/18 super-pathways (see all 18) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Activation of Genes by ATF4

Activation of Genes by ATF4

1.00

PERK regulated gene expression

0.64

Rho Family GTPases

MAPK Signaling

0.51

ILK Signaling

0.45

Expression of ATF3

Expression of ATF3

1.00

Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

1.00

SMAD Signaling Network

SMAD Signaling Network

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ATF3 (see all 8)

	MAPK Signaling
	PI3K Signaling in B-Lymphocyte
	iNOS Signaling
	SMAD Signaling Network
	TNF Signaling

5/6 BioSystems Pathways for ATF3 (see all 6)

	Myometrial Relaxation and Contraction Pathways
	Id Signaling Pathway
	TGF-beta Receptor Signaling Pathway
	Direct p53 effectors
	Regulation of nuclear SMAD2/3 signaling

5 Reactome Pathways for ATF3

	Expression of ATF3
	PERK regulated gene expression
	Metabolism of proteins
	Activation of Genes by ATF4
	Unfolded Protein Response

1 PharmGKB Pathway for ATF3

Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

ATF3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ATF3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/50 Interacting proteins for ATF3 (P18847^{1, 2, 3} ENSP00000344352⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 50)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
JUN	P05412²^,³, ENSP00000360266⁴	MINT-6628036 I2D: score=5 STRING: ENSP00000360266
RELA	Q04206¹^,³, ENSP00000384273⁴	EBI-712767,EBI-73886 I2D: score=3 STRING: ENSP00000384273
FHL2	Q14192¹^,³, ENSP00000322909⁴	EBI-712767,EBI-701903 I2D: score=1 STRING: ENSP00000322909
TP53	P04637³, ENSP00000269305⁴	I2D: score=6 STRING: ENSP00000269305
JUND	P17535³, ENSP00000252818⁴	I2D: score=4 STRING: ENSP00000252818

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006094	gluconeogenesis	IEA	--
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0006987	activation of signaling protein activity involved in unfolded protein response	TAS	--
GO:0008284	positive regulation of cell proliferation	IEA	--

ATF3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ATF3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ATF3

1 HMDB Compound for ATF3 About this table

Compound	Synonyms	CAS #	PubMed Ids
Cyclic AMP	Cyclic AMP (see all 19)	60-92-4	--

10/30 Novoseek chemical compound relationships for ATF3 gene (see all 30) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
sulindac sulfide	73.1	9	16079301 (3), 15897233 (2), 19934343 (1), 20130018 (1)
amino acid	59.7	12	16989641 (4), 17042743 (1), 16026328 (1), 12881527 (1)
anisomycin	55.1	9	17014422 (2), 8576171 (2), 16394627 (1), 19101521 (1)
deoxynivalenol	41.5	5	19360757 (2), 19101521 (1), 19591856 (1)
indole-3-carbinol	39.5	1	15670751 (1)
leucine	37.9	8	12815047 (1), 12225289 (1), 8152431 (1), 16516039 (1) (see all 5)
oligonucleotide	34.4	4	10965025 (2), 11589305 (1), 15280448 (1)
cyclic amp	34.1	14	7935470 (2), 17952119 (1), 8007991 (1), 19705082 (1) (see all 8)
troglitazone	32.3	4	16079301 (2), 15897233 (1)
resveratrol	24	2	15897233 (1), 18776171 (1)

Search CenterWatch for drugs/clinical trials and news about ATF3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ATF3 gene (8 alternative transcripts):

NM_001030287.3 NM_001040619.2 NM_001206484.2 NM_001206486.2 NM_001206488.2 NM_001674.3 NM_001206485.1 NM_004024.4

Unigene Cluster for ATF3:

Activating transcription factor 3

Hs.460 [show with all ESTs]

Unigene Representative Sequence: NM_001040619

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000366981 ENST00000341491(uc021pit.1 uc001hjh.3 uc021piu.1 uc001hji.3 uc021piv.1)

ENST00000465155(uc001hjj.3) ENST00000366985 ENST00000492118 ENST00000464547

ENST00000366983 ENST00000336937 ENST00000366987(uc001hjf.3)

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		SwitchGear 3'UTR luciferase reporter plasmid: ATF3 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATF3

Additional cDNA sequence:

AB066566.1 AB078026.1 AB078027.1 AB078028.1 AK125255.1 AK312998.1 AY313927.1 BC006322.2

BT006996.1 CR450334.1 L19871.1

22 DOTS entries:

DT.216448 DT.95279991 DT.70100962 DT.100029805 DT.99961573 DT.97844923 DT.100887717 DT.95279990

DT.70103799 DT.91775485 DT.100887713 DT.121438085 DT.100706708 DT.101981395 DT.100887716 DT.95279988

DT.121438139 DT.121438163 DT.95279994 DT.95279995 DT.97844922 DT.95279985

24/277 AceView cDNA sequences (see all 277):

BQ417074 BM764708 BF001761 BF938962 BF445768 CR602765 BC006322 CR612905

AW028160 AB078027 CB068770 AL520149 AI081317 BM773048 BQ718096 CR450334

CB156560 CR614684 W15409 AA515294 BU752221 BM764975 AU134034 AB078028

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for ATF3 (see all 11) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	·	2d	^	3	^	4a	·	4b	·	4c	·	4d	^	5a	·	5b	^	6a	·	6b	·	6c	·	6d	^	7a	·	7b	·	7c	^	8a	·	8b
SP1:											-		-										-						-		-		-		-		-
SP2:													-										-
SP3:											-		-										-						-		-
SP4:																			-				-						-		-
SP5:																							-						-		-

ECgene alternative splicing isoforms for ATF3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ATF3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGCTGTTTT

About this image

ATF3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

6 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Primitive Heart Tube

Primitive Heart Tube Cells

Myocardium

Pancreas

Dorsal Pancreatic Bud

Immature Beta Progenitor Cells

Pancreas

Ventral Pancreatic Bud

Immature Beta Progenitor Cells

Pancreas

Somite

Thoracic Ventrolateral Dermomyotome Lip

Muscle Progenitor Cells

Skeletal Muscle

Testis

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

Posterior foregut-like cells (A scalable, suspensi...)

See ATF3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ATF3

SOURCE GeneReport for Unigene cluster: Hs.460

SABiosciences Expression via Pathway-Focused PCR Arrays including ATF3:

cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

Nephrotoxicity in human mouse rat

TGFB Signaling Targets in human mouse rat

Polycomb & Trithorax Target Genes in human mouse rat

Transcription Factors in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATF3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATF3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ATF3 gene from 4/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ATF3¹	activating transcription factor 3	77.26(n) 87.42(a)		421369 XM_419429.3 XP_419429.3
lizard (Anolis carolinensis)	Reptilia	ATF3⁶	--	85(a)	1 ↔ 1	1(238620254-238623623)
zebrafish (Danio rerio)	Actinopterygii	zgc55526²	similar to activating transcription factor 3	73.64(n)		393939 BC045371.1
fruit fly (Drosophila melanogaster)	Insecta	Atf3⁶	Activating transcription factor 3	8(a)	1 → many	X(1136773-1168682)

ENSEMBL Gene Tree for ATF3 (if available)
TreeFam Gene Tree for ATF3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ATF3 gene

FOSL1² JDP2² FOSB² FOS² FOSL2²

10 SIMAP similar genes for ATF3 using alignment to 4 protein entries: ATF3_HUMAN (see all proteins):

FOSB FOSL2 FOS FOSL1 BATF3 JDP2

ATF2 CREB5 CREB3L1 BATF

ATF3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs111368586^1,2		--	183414092(+)	`AGGCCG/AGTCTC`	1	--	us2k¹		1		CSA	2
rs58402000^1,2		--	183414112(+)	`ACCTCA/GTGATC`	1	--	us2k¹		0	--	--	--	--
rs74582463^1,2	C	--	183414321(+)	`AGGTGT/CGTAGT`	1	--	us2k¹		2		WA	120
rs77487361^1,2		--	183414891(+)	`ATTCCG/ACTGTA`	1	--	us2k¹		1		EA	120
rs116874158^1,2	C,F	--	183415338(+)	`TCTCCC/TGTGAA`	1	--	us2k¹		1		EA	120
rs1195473^1,2	C,F,H	--	183415386(-)	`CCTTCG/AAGCCA`	1	--	us2k¹		9		NS EA NA WA	924
rs41314256^1,2	C,F	--	183415399(+)	`AGCCTC/TGGTGG`	1	--	us2k¹		2		WA NA	238
rs41305114^1,2	C,F	--	183415479(+)	`NNNNGG/ATGGGG`	1	--	ut5¹		1		NA	120
rs56671266^1,2	C,F	--	183416038(+)	`AGCCAT/CTGGAG`	1	--	int¹		8		WA NA CSA EA	368
rs72756328^1,2	C,F	--	183416057(+)	`CCCCTT/CCCTTC`	1	--	int¹		2		WA NA	238

HapMap Linkage Disequilibrium report for ATF3 (212738676 - 212794119 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ATF3
1 CNV: 3329
Human Gene Mutation Database (HGMD): ATF3

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ATF3 for disorders           About GeneDecksing

OMIM gene information: 603148    OMIM disorders: --

20/41 diseases for ATF3 (see all 41):    About MalaCards

erythema multiforme uterine fibroid amyotrophic lateral sclerosis lateral sclerosis

hypospadias esophageal squamous cell carcinoma squamous cell carcinoma adult t-cell leukemia

insulin resistance neuroectodermal tumors wilms tumor anoxia

hodgkin's lymphoma t-cell leukemia keratitis bone cancer

colon cancer ovarian cancer colorectal cancer skin cancer

1 disease from the University of Copenhagen DISEASES database for ATF3:

Hypospadias

10/21 Novoseek disease relationships for ATF3 gene (see all 21) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hypospadias	59.6	35	18804813 (9), 18426833 (6), 16306208 (4), 18001166 (3) (see all 7)
tumors	34.3	36	18808719 (3), 17178897 (3), 15674352 (2), 17952119 (2) (see all 17)
adenovirus infections	28.2	1	16860366 (1)
colon cancer	23.9	7	10965025 (3), 11341467 (1), 11589305 (1), 19063862 (1) (see all 5)
cancer	23.3	20	17952119 (3), 19136462 (3), 16628010 (2), 16847457 (1) (see all 9)
inflammation	20.8	6	18794337 (2), 12161427 (1), 19155971 (1), 18315734 (1) (see all 5)
colorectal cancer	13.6	9	17964072 (2), 16489044 (2), 15897233 (1), 15670751 (1) (see all 7)
carcinoma squamous cell	12	3	19423649 (1), 18808719 (1), 11092977 (1)
leukemia t-cell	10	1	8007991 (1)
cell damage	9.53	2	16854522 (1)

Human Genome Epidemiology (HuGE) Navigator: ATF3 (8 documents)

Export disorders for ATF3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ATF3 gene, integrated from 9 sources (see all 278):
(articles sorted by number of sources associating them with ATF3)

Utopia: connect your pdf to the dynamic
world of online information

ATF3 and ATF3 delta Zip. Transcriptional repression versus activation by alternatively spliced isoforms. (PubMed id 7515060)^{1, 2, 3, 9} Chen B.P.C.... Hai T. (1994)
Amino acid deprivation and endoplasmic reticulum stress induce expression of multiple activating transcription factor-3 mRNA species that, when overexpressed in HepG2 cells, modulate transcription by the human asparagine synthetase promoter. (PubMed id 12881527)^{1, 2, 9} Pan Y....Kilberg M.S. (2003)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
An unappreciated role for RNA surveillance. (PubMed id 14759258)^{1, 2} Hillman R.T.... Brenner S.E. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
An alternatively spliced isoform of transcriptional repressor ATF3 and its induction by stress stimuli. (PubMed id 12034827)^{1, 2} Hashimoto Y.... Kitajima S. (2002)
Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers. (PubMed id 2516827)^{1, 2} Hai T.... Green M.R. (1989)
Transcriptional regulation of activating transcription factor 3 involves the early growth response-1 gene. (PubMed id 16079301)^{1, 9} Bottone F.G....Eling T.E. (2005)
Coxsackievirus B3 modulates cell death by downregulating activating transcription factor 3 in HeLa cells. (PubMed id 17599613)^{1, 9} Hwang H.Y....Park S.I. (2007)
The regulation of ATF3 gene expression by mitogen-activated protein kinases. (PubMed id 17014422)^{1, 9} Lu D....Hai T. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 467	HGNC: 785	AceView: ATF3	Ensembl:ENSG00000162772	euGenes: HUgn467
ECgene: ATF3	H-InvDB: ATF3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ATF3	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ATF3	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/atf3/

Intellectual Property for ATF3 gene
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Patent Information for ATF3 gene:
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activating transcription factor 3

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