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ATF3 Gene

protein-coding GIFtS: 57

GC01P210805

activating transcription factor 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ATF3deltaZip2 ^²
ATF3deltaZip2c ^²
ATF3deltaZip3 ^²
OTTHUMP00000034887 ^²
OTTHUMP00000034890 ^²

Descriptions
activating transcription factor 3 ^², ³
cAMP-dependent transcription factor ATF-3 ^³

External Ids
HGNC: 785¹
Entrez Gene: 467²
UniProtKB: P18847³
Ensembl: ENSG00000162772⁷

Search outside databases for aliases for ATF3 gene

Previous GC identifers: GC01P211461 GC01P208625 GC01P209398 GC01P209838 GC01P209170

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ATF3:

Activating transcription factor 3 is a member of the mammalian activation transcription factor/cAMP

responsive element-binding (CREB) protein family of transcription factors. Multiple transcript

variants encoding two different isoforms have been found for this gene. The longer isoform

represses rather than activates transcription from promoters with ATF binding elements. The

shorter isoform (deltaZip2) lacks the leucine zipper protein-dimerization motif and does not bind

to DNA, and it stimulates transcription presumably by sequestering inhibitory co-factors away from

the promoter. It is possible that alternative splicing of the ATF3 gene may be physiologically

important in the regulation of target genes. [provided by RefSeq]

UniProtKB/Swiss-Prot: ATF3_HUMAN, P18847

Function: This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a

sequence present in many viral and cellular promoters. Represses transcription from promoters with

ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the

promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away

from the promoters

Gene Wiki entry for ATF3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ATF3 gene

Entrez Gene cytogenetic band: 1q32.3 Ensembl cytogenetic band: 1q32.3 HGNC cytogenetic band: 1q32.3

ATF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P210805: (about GC identifiers)

Start:	210,805,320 bp from pter
End:	210,860,740 bp from pter
Size:	55,421 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_021877.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ATF3_HUMAN, P18847 (See protein sequence)

Recommended Name: Cyclic AMP-dependent transcription factor ATF-3

Size: 181 amino acids; 20576 Da

Subunit: Binds DNA as a homodimer or a heterodimer

Subcellular location: Nucleus

Alternative splicing: 2 isoforms: P18847-1 P18847-2

REFSEQ proteins (4 alternative transcripts):

NP_001025458.1 NP_001035709.1 NP_001665.1 NP_004015.4

ENSEMBL proteins:

ENSP00000355954 ENSP00000344352 ENSP00000375771 ENSP00000355951 ENSP00000355950 ENSP00000336908

ENSP00000355948 ENSP00000355952

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ATF3)
	Human Recombinant Proteins from Abnova (ATF3)

OriGene Purified Recombinant Human Protein: ATF3

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005730	nucleolus	IDA	18029348

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Antibodies for ATF3:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ATF3
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ATF3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ATF3)
	Novus Biologicals Antibodies for ATF3

Assays for ATF3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P18847

ProtoNet protein and cluster: P18847

1 Blocks protein family: IPB000837 Fos transforming protein signature

UniProtKB/Swiss-Prot: ATF3_HUMAN, P18847

Similarity: Belongs to the bZIP family. ATF subfamily

Similarity: Contains 1 bZIP domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ATF3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ATF3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001040619

Applied Biosystems Silencer® siRNAs for ATF3

Sigma-Aldrich siRNA for ATF3

Sigma-Aldrich shRNA Panels and shRNA for ATF3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ATF3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001030287
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001030287
untagged cDNA clones in CMV expression vector (see all 6): AB078027

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001674

UniProtKB/Swiss-Prot: ATF3_HUMAN, P18847

Function: This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a

sequence present in many viral and cellular promoters. Represses transcription from promoters with

ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the

promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away

from the promoters

4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Atf3):

digestive/alimentary

endocrine/exocrine gland

immune system

respiratory system

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	TAS	7515060
GO:0003714	transcription corepressor activity	TAS	7515060
GO:0042802	identical protein binding	IPI	18255255
GO:0043565	sequence-specific DNA binding	IEA	--
GO:0046983	protein dimerization activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for ATF3

5/41 Interacting proteins for ATF3 (ENSP00000355954³ P18847^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 41 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RELA	Q04206¹	STRING (score=.85) EBI-712767, EBI-73886
ATF3	P18847¹	EBI-712767, EBI-712767
FHL2	Q14192¹	EBI-712767, EBI-701903
JUN	P05412²	MINT-6628036
SMAD3	ENSP00000332973³	STRING (score=.994)

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ATF3
10/16 Novoseek chemical compound relationships for ATF3 gene (see all 16 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
amino acid	61.84	12	16989641 (4), 17042743 (1), 16026328 (1), 12881527 (1)
leucine	37.99	6	12815047 (1), 12225289 (1), 8152431 (1), 16516039 (1)
oligonucleotide	37.33	4	10965025 (2), 11589305 (1), 15280448 (1)
deoxynivalenol	33.65	3	19360757 (2), 19101521 (1)
cyclic amp	33.30	12	7935470 (2), 17952119 (1), 8007991 (1), 16263788 (1) (see all 7)
ccl4	6.95	7	8622660 (3), 9343434 (1)
12-o-tetradecanoylphorbol 13-acetate	5.78	7	17108111 (5)
oxygen	0.00	3	16847457 (1), 12833146 (1), 18776171 (1)
nitric oxide	0.00	5	15102941 (3), 15199129 (2)
homocysteine	0.00	10	10979959 (6), 11726207 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ATF3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ATF3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001040619

Sigma-Aldrich siRNA for ATF3

Sigma-Aldrich shRNA Panels and shRNA for ATF3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001030287 NM_001040619 NM_001674 NM_004024

REFSEQ mRNAs for ATF3 gene (4 alternative transcripts):

NM_001030287.2 NM_001040619.1 NM_001674.2 NM_004024.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001030287 NM_001040619 NM_001674 NM_004024

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001030287
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001030287
                                 untagged cDNA clones in CMV expression vector (see all 6): AB078027

Additional cDNA sequence:

AB066566.1 AB078026.1 AB078027.1 AB078028.1 AK123699.1 AK125255.1 AK294296.1 AK312998.1

AY313926.1 AY313927.1 BC006322.2 BT006996.1 CR450334.1 CR600751.1 CR602765.1 CR612905.1

CR614684.1 CR614862.1 CR619424.1 CR620886.1 CR626784.1 L19871.1

23 DOTS entries:

DT.216448 DT.70100962 DT.95279991 DT.100029805 DT.97844923 DT.99961573 DT.100887717 DT.95279990

DT.70103799 DT.100887713 DT.100887716 DT.91775485 DT.121438085 DT.100706708 DT.95279995 DT.101981395

DT.121438139 DT.95279988 DT.97844922 DT.100887714 DT.121438163 DT.95279985 DT.95279994

24/277 AceView cDNA sequences (see all 277 ):

AB078026 CR600751 CR450334 AY313926 BM742949 AU141602 AB078028 BU752221

AB078027 AW028160 BC006322 CR612905 CB155444 AI800224 BX337431 AB066566

BQ718096 AA515294 CR614862 W15409 BQ417074 AL520149 CR614684 CR626784

highest scoring ESTs for ATF3:

L19871 AA085959 AA099382 AA099461 AA417667 AA420650 AA420689 AA463748 AA490707 AA515294

Unigene Cluster for ATF3:

Activating transcription factor 3

Hs.460 [show with all ESTs]

Unigene Representative Sequence: NM_001040619

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for ATF3 (see all 11 )

ExUns:	1	^	2a	·	2b	·	2c	·	2d	^	3	^	4a	·	4b	·	4c	·	4d	^	5a	·	5b	^	6a	·	6b	·	6c	·	6d	^	7a	·	7b	·	7c	^	8a	·	8b
SP1:											-		-										-						-		-		-		-		-
SP2:													-										-
SP3:											-		-										-						-		-
SP4:																			-				-						-		-
SP5:																							-						-		-

About this scheme

ECgene alternative splicing isoforms for ATF3

8 Ensembl transcripts including schematic representations:

ENST00000366987 ENST00000341491 ENST00000391902 ENST00000366984 ENST00000366983 ENST00000336937

ENST00000366981 ENST00000366985

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ATF3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ATF3

¹ / ² / ³

5 probe-sets matching ATF3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
287_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	L19871	1.00	1.00	1.00	1
202672_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001674	0.60	1.00	0.82	1
1554420_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1554980_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202672_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ATF3 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TAGCTGTTTT

SOURCE GeneReport for Unigene cluster: Hs.460
Expression variation in blood from EXPOLDB for ATF3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ATF3 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ATF3¹	--	activating transcription factor 3	93.37(n) 96.69(a)	612911 XM_847382.1 XP_852475.1
chimpanzee (Pan troglodytes)	ATF3¹	--	activating transcription factor 3	98.9(n) 98.9(a)	469143 XM_524528.2 XP_524528.2
cow (Bos taurus)	ATF3¹	--	activating transcription factor 3	93.74(n) 95.58(a)	515266 NM_001046193.1 NP_001039658.1
rat (Rattus norvegicus)	Atf3¹	--	activating transcription factor 3	88.03(n) 95.03(a)	25389 NM_012912.1 NP_037044.1
mouse (Mus musculus)	Atf3^{1, 5}	1 (103.20 cM)⁵	activating transcription factor 3^{1, 5}	88.95(n)¹ 95.03(a)¹	11910¹ NM_007498.2¹ NP_031524.2¹ AB291912⁵ AK133965⁵ (see all 15)

About this table Species with no ortholog for ATF3

ENSEMBL Gene Tree for ATF3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for ATF3 gene

JDP2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/399 NCBI SNPs in ATF3 are shown (see all 399 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 170)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1126526^1,2	A,C,F,H,O	210860128(+)	`GGGGGC/TGGGGC`	4	--	ut3¹ ese³		12	NS MN EU EA WA	1256
	rs10475^1,2	A,C,F,H	210860236(+)	`GGCAGC/TATGAT`	4	--	ut3¹ ese³		21	MN EA NS NA EU WA	3488
	rs4406706^1,2	A,C,F,H	210847094(+)	`CGTGGA/GGAGGT`	4	--	ng5¹ int¹		5	EU EA WA NS	596
	rs1195474^1,2	A,C,F,H	210804825(-)	`aggcaT/Atacaa`	1	--	ng5¹		8	EU EA WA	836
	rs4951627^1,2	A,C,F,H	210847649(+)	`CTGAAG/CATGGG`	4	--	ng5¹ int¹		12	NS EU EA WA NA	1100
	rs1126700^1,2	C,F,H	210860472(+)	`TTAGCA/GTTATT`	4	--	ut3¹		16	NS MN EU EA WA NA	1472
	rs11571558^1,2	C,F,H	210860915(+)	`CCTCAG/CTCTTG`	4	--	ng3¹		14	NS EU EA WA NA	1214
	rs1803173^1,2	C,F,H	210859673(+)	`TCAGCA/GGGCCC`	4	--	ut3¹ ese³		5	NS EU EA WA	582
	rs11571553^1,2	C,F,H	210859203(+)	`CTCTCG/ACAGCT`	4	--	ut3¹ int¹ ese³		9	NS EU EA WA	1016
	rs11571556^1,2	C,F,H	210860054(+)	`TCCGAT/CGTTTG`	4	--	ut3¹		5	NS EU EA WA	598

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HapMap Linkage Disequilibrium images for ATF3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603148

10/21 Novoseek disease relationships for ATF3 gene (see all 21 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hypospadias	53.80	30	18804813 (9), 18426833 (6), 16306208 (4), 18001166 (3) (see all 5)
adenovirus infections	31.38	1	16860366 (1)
tumors	28.95	29	18808719 (3), 17178897 (3), 15674352 (2), 17952119 (2) (see all 13)
colon cancer	18.65	6	10965025 (3), 11341467 (1), 11589305 (1), 19063862 (1)
cancer	14.78	17	17952119 (3), 19136462 (3), 16628010 (2), 16847457 (1) (see all 6)
inflammation	13.57	5	18794337 (2), 12161427 (1), 19155971 (1), 18315734 (1)
colorectal cancer	13.53	8	17964072 (2), 16489044 (2), 15897233 (1), 15670751 (1) (see all 6)
leukemia t-cell	13.09	1	8007991 (1)
prostate cancer	12.62	19	18755691 (4), 16516039 (4), 17178897 (4), 18998462 (1)
breast cancer	8.72	1	9927194 (1)

About this table

Human Genome Epidemiology Navigator: ATF3 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/188 PubMed articles for ATF3 gene (see all 188 ):

ATF3 and ATF3 delta Zip. Transcriptional repression versus activation by alternatively spliced isoforms. (PubMed id 7515060)^{1, 2, 3, 4} Chen B.P.C.... Hai T. (1994)
An unappreciated role for RNA surveillance. (PubMed id 14759258)^{3, 4} Hillman R.T.... Brenner S.E. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers. (PubMed id 2516827)^{3, 4} Hai T.... Green M.R. (1989)
Transcriptional regulation of activating transcription factor 3 involves the early growth response-1 gene. (PubMed id 16079301)^{1, 3} Bottone F.G....Eling T.E. (2005)
The regulation of ATF3 gene expression by mitogen-activated protein kinases. (PubMed id 17014422)^{1, 3} Lu D....Hai T. (2007)
Coxsackievirus B3 modulates cell death by downregulating activating transcription factor 3 in HeLa cells. (PubMed id 17599613)^{1, 3} Hwang H.Y....Park S.I. (2007)
ATF3 induction following DNA damage is regulated by distinct signaling pathways and over-expression of ATF3 protein suppresses cells growth. (PubMed id 12386811)^{1, 3} Fan F....Zhan Q. (2002)
Estradiol upregulates activating transcription factor 3, a candidate gene in the etiology of hypospadias. (PubMed id 18001166)^{1, 3} Liu B....Baskin L.S. (2007)
Activation of the ATF3 gene through a co-ordinated amino acid-sensing response programme that controls transcriptional regulation of responsive genes following amino acid limitation. (PubMed id 16989641)^{1, 3} Pan Y.X....Kilberg M.S. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 467	HGNC: 785	AceView: ATF3	Ensembl:ENSG00000162772	euGenes: HUgn467
ECgene: ATF3	H-InvDB: ATF3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ATF3	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/atf3/

Licensable Technologies for ATF3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ATF3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ATF3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ATF3		Antibodies for ATF3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ATF3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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Antibodies for ATF3

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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ATF3 Gene at Home site.
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ATF3 Gene

protein-coding GIFtS: 57

Aliases &
Descriptions
for ATF3

Summaries
for ATF3

Genomic Location
for ATF3

Proteins
for ATF3

Protein Domains/
Families
for ATF3

Gene Function
for ATF3

Pathways & Interactions
for ATF3

Drugs & Compounds
for ATF3

Transcripts
for ATF3

Expression
for ATF3

Orthologs
for ATF3

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SNPs/Variants
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Disorders & Mutations
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for ATF3

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for ATF3

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for ATF3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ATF3 Gene

protein-coding GIFtS: 57

Aliases & Descriptionsfor ATF3

Summariesfor ATF3

Genomic Locationfor ATF3

Proteinsfor ATF3

Protein Domains/Familiesfor ATF3

Gene Functionfor ATF3

Pathways & Interactionsfor ATF3

Drugs & Compoundsfor ATF3

Transcriptsfor ATF3

Expression for ATF3

Orthologsfor ATF3

Paralogsfor ATF3

SNPs/Variantsfor ATF3

Disorders & Mutationsfor ATF3

Medical Newsfor ATF3

Publicationsfor ATF3

Search for ATF3

Genome Databases showing ATF3

Other Databases showing ATF3

Specialized Databases showing ATF3

Licensable Technologiesfor ATF3

Servicesfor ATF3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ATF3

Summaries
for ATF3

Genomic Location
for ATF3

Proteins
for ATF3

Protein Domains/
Families
for ATF3

Gene Function
for ATF3

Pathways & Interactions
for ATF3

Drugs & Compounds
for ATF3

Transcripts
for ATF3

Expression
for ATF3

Orthologs
for ATF3

Paralogs
for ATF3

SNPs/Variants
for ATF3

Disorders & Mutations
for ATF3

Medical News
for ATF3

Publications
for ATF3

Licensable Technologies
for ATF3

Services
for ATF3