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ATF2 Gene

protein-coding GIFtS: 71

GC02M175645

activating transcription factor 2
(Previous name: cAMP responsive element binding protein 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CREB2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CRE-BP1 ^¹, ²
CREB-2 ^³
CREB2 ^², ³, ⁵
CREBP1 ^³
HB16 ^¹, ², ³
MGC111558 ^²
OTTHUMP00000163262 ^²
TREB7 ^¹, ²

Descriptions
Cyclic AMP-responsive element-binding protein 2 ^³
activating transcription factor 2 ^², ³
activating transcription factor 2 splice variant ATF2-var2 ^²
cAMP response element-binding protein CRE-BP1 ^³
cAMP responsive element binding protein 2 ^¹
cAMP responsive element binding protein 2, formerly ^²
cAMP-dependent transcription factor ATF-2 ^³
cAMP-responsive element-binding protein 2 ^³

External Ids
HGNC: 784¹
Entrez Gene: 1386²
UniProtKB: P15336³
Ensembl: ENSG00000115966⁷

Search outside databases for aliases for ATF2 gene

Previous GC identifers: GC02M173991 GC02M174600 GC02M175903 GC02M176141 GC02M175762

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ATF2:

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA

binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric

palindrome. The protein forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent

transcription. The protein is also a histone acetyltransferase (HAT) that specifically acetylates

histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that

activate transcription by direct effects on chromatin components. Additional transcript variants

have been identified but their biological validity has not been determined. [provided by RefSeq]

UniProtKB/Swiss-Prot: ATF2_HUMAN, P15336

Function: Transcriptional activator, probably constitutive, which binds to the cAMP-responsive

element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular

promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the

12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2-c-Jun complex

Gene Wiki entry for ATF2 (Activating_transcription_factor_2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ATF2 gene

Entrez Gene cytogenetic band: 2q32 Ensembl cytogenetic band: 2q31.1 HGNC cytogenetic band: 2q32

ATF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M175645: (about GC identifiers)

Start:	175,645,224 bp from pter
End:	175,741,180 bp from pter
Size:	95,957 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000002.10 NT_005403.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ATF2_HUMAN, P15336 (See protein sequence)

Recommended Name: Cyclic AMP-dependent transcription factor ATF-2

Size: 505 amino acids; 54537 Da

Subunit: Binds DNA as a dimer and can form a homodimer in the absence of DNA. Can form a

heterodimer with JUN. Interacts with SMAD3 and SMAD4. Binds through its N-terminal region to UTF1

which acts as a coactivator of ATF2 transcriptional activity

Subcellular location: Nucleus

Caution: It is uncertain whether Met-1 or Met-19 is the initiator

PDB structure from and Proteopedia :

1BHI (3D)

1T2K (3D)

Secondary accessions: Q13000 Q4ZFU9 Q53RY2

Alternative splicing: 2 isoforms: P15336-1 P15336-2

Post-translational modifications:

Phosphorylation of Thr-69 and Thr-71 by MAPK14 causes increased transcriptional activity. Also

phosphorylated and activated by JNK¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001871.2

ENSEMBL proteins:

ENSP00000264110 ENSP00000376326 ENSP00000376327 ENSP00000386282 ENSP00000386326 ENSP00000340576

ENSP00000387093 ENSP00000386526

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant ATF2 Protein
	Sigma-Aldrich Proteins for ATF2
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for ATF2
	Recombinant Proteins from Abcam (ATF2)
	Human Recombinant Proteins from Abnova (ATF2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IEA	--
GO:0005829	cytosol	EXP	9030721 10878576

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Antibodies for ATF2:

	Invitrogen Antibodies for ATF2
	Millipore Mono- and Polyclonal Antibodies for the study of ATF2
	Sigma-Aldrich Antibody Arrays and Antibodies for ATF2
	R&D Systems Antibodies for ATF2
	Cell Signaling Technology (CST) Antibodies for ATF2 (ATF-2)
	Antibodies from Abcam (ATF2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ATF2)
	Novus Biologicals Antibodies for ATF2

Assays for ATF2:

	Invitrogen Assays for ATF2
	Millipore Kits and Assays for the Analysis of ATF2
	Browse R&D Systems for biochemical assays
	Cell Signaling Technology (CST) Sandwich ELISA Kits for ATF2 (ATF-2)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P15336

ProtoNet protein and cluster: P15336

1 Blocks protein family: IPB011616 bZIP transcription factor

UniProtKB/Swiss-Prot: ATF2_HUMAN, P15336

Similarity: Belongs to the bZIP family. ATF subfamily

Similarity: Contains 1 bZIP domain

Similarity: Contains 1 C2H2-type zinc finger

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ATF2)
		Millipore RNAi Products for the Analysis of ATF2 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (ATF2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001880

Applied Biosystems Silencer® siRNAs for ATF2

Sigma-Aldrich siRNA for ATF2

Sigma-Aldrich shRNA Panels and shRNA for ATF2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ATF2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001880
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001880
untagged cDNA clone in CMV expression vector: NM_001880

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001880

UniProtKB/Swiss-Prot: ATF2_HUMAN, P15336

Function: Transcriptional activator, probably constitutive, which binds to the cAMP-responsive

element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular

promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the

12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2-c-Jun complex

Genatlas biochemistry entry for ATF2:

activating transcription factor 2,cAMP response element binding protein

15/20 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Atf2) (see all 20 ):

	behavior/neurological	cellular	embryogenesis	growth/size
hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	lethality-postnatal
lethality-prenatal/perinatal	limbs/digits/tail	liver/biliary system	nervous system	normal

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	IEA	--
GO:0003702	RNA polymerase II transcription factor activity	TAS	10909971
GO:0003713	transcription coactivator activity	TAS	2529117
GO:0008270	zinc ion binding	IEA	--
GO:0043565	sequence-specific DNA binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/35 Sigma-Aldrich "Your Favorite Gene" Pathways for ATF2 (Your Favorite Gene powered by Ingenuity) (see all 35 )

ERK/MAPK Signaling
Cholecystokinin/Gastrin-mediated Signaling
B Cell Receptor Signaling
FLT3 Signaling in Hematopoietic Progenitor Cells
Role of PKR in Interferon Induction and Antiviral Response

GeneDecks ATF2 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for ATF2

5/42 Interacting proteins for ATF2 (P15336^{1, 2} ENSP00000264110³) via UniProtKB, MINT, and/or STRING (see all 42 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAPK14	Q16539², ENSP00000229794³	MINT-4789501 STRING (score=.999)
JDP2	Q8WYK2², ENSP00000267569³	MINT-6699748 STRING (score=.88)
VRK1	Q99986¹, ENSP00000216639³	EBI-1170906, EBI-1769146 STRING (score=.802)
MAPK11	Q15759¹^,², ENSP00000333685³	EBI-1170906, EBI-298304 MINT-4789511 EBI-1170906, EBI-298304 MINT-4789511 STRING (score=.999)
MAPK13	O15264¹	EBI-1170906, EBI-2116951

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ATF2
10/22 Novoseek chemical compound relationships for ATF2 gene (see all 22 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
sp 600125	76.11	6	12663670 (1), 15466475 (1), 12898508 (1), 17397142 (1) (see all 6)
leucine	63.32	49	8479741 (5), 8440710 (3), 1836214 (2), 2320002 (2) (see all 20)
cyclic amp	58.26	32	1453687 (4), 10871653 (2), 8816436 (1), 15663480 (1) (see all 16)
pd 98,059	50.89	2	12663670 (1), 16050133 (1)
12-o-tetradecanoylphorbol 13-acetate	38.88	12	19176525 (3), 8020141 (1), 8440710 (1), 12592382 (1) (see all 6)
threonine	38.02	6	19176525 (1), 11533064 (1), 17397142 (1), 11163354 (1) (see all 6)
forskolin	22.15	1	14519095 (1)
tyrosine	13.35	8	15663480 (1), 12196528 (1), 16515541 (1), 16452470 (1) (see all 7)
phosphoenolpyruvate	12.71	1	9712902 (1)
okadaic acid	8.50	2	11163354 (1), 10777545 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ATF2)
		Millipore RNAi Products for the Analysis of ATF2 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (ATF2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001880

Sigma-Aldrich siRNA for ATF2

Sigma-Aldrich shRNA Panels and shRNA for ATF2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001880

REFSEQ mRNAs for ATF2 gene:

NM_001880.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001880

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001880
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001880
                                 untagged cDNA clone in CMV expression vector: NM_001880

Additional cDNA sequence:

AF283776.2 AK128731.1 AL050192.1 AY029364.1 BC026175.1 BC107698.1 BC130335.1 BC130337.1

BX648469.1 DQ003036.1 DQ003037.1 DQ003038.1 DQ003039.1 DQ003040.1 DQ003041.1 DQ003042.1

DQ003043.1 DQ003044.1 DQ003045.1 DQ003046.1 DQ003047.1 DQ003048.1 DQ003049.1 M31630.1

U16028.1 X15875.1

22 DOTS entries:

DT.120968633 DT.100783893 DT.95106445 DT.100783898 DT.100716537 DT.40295835 DT.120968676 DT.120968505

DT.120968595 DT.313621 DT.120968464 DT.120968580 DT.92040518 DT.95132221 DT.92381070 DT.120968564

DT.120968630 DT.95113271 DT.120968507 DT.120968548 DT.120968666 DT.120968730

24/167 AceView cDNA sequences (see all 167 ):

AA417022 AW591709 AW576316 AW593615 BX107614 AI824548 CA413806 AA151848

AI571921 BQ086150 BF477989 AK128731 BM312012 BM083469 CK821771 BF477683

BQ722122 AI620747 AA773979 BM980871 CK821770 NM_001880 AI078416 BU620862

highest scoring ESTs for ATF2:

AL050192 AL119505 AU279581 BC026175 BI548366 CB961368 U16028 X15875 AA083516 AA151848

Unigene Cluster for ATF2:

Activating transcription factor 2

Hs.592510 [show with all ESTs]

Unigene Representative Sequence: BC107698

GeneLoc Exon Structure

5/17 Alternative Splicing Database (ASD) splice patterns (SP) for ATF2 (see all 17 )

ExUns:	1	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13a	·	13b	^	14	^	15a	·	15b	^	16	^	17a	·	17b
SP1:																					-																-
SP2:																					-																-				-
SP3:																					-		-														-				-
SP4:																					-												-				-		-		-
SP5:											-		-								-																-		-		-

About this scheme

ECgene alternative splicing isoforms for ATF2

8 Ensembl transcripts including schematic representations:

ENST00000264110 ENST00000392543 ENST00000392544 ENST00000409499 ENST00000409437 ENST00000345739

ENST00000409635 ENST00000409833

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ATF2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ATF2

¹ / ² / ³

8 probe-sets matching ATF2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37575_at²^{, 3}	U95-A	1	1.00	1.00	0.81	1.25	AL050192	0.80	1.00	0.91	1
38902_r_at²^{, 3}	U95-A	1	1.00	1.00	0.80	0.71	X15875	0.80	1.00	0.91	1
1994_at²^{, 3}	U95-A	1	1.00	1.00	0.95	1.04	U16028	0.80	1.00	0.91	1
212984_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BE786164	0.60	1.00	0.82	1
205446_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001880	0.60	1.00	0.82	1
212984_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1555146_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205446_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGTAAACCAT

SOURCE GeneReport for Unigene cluster: Hs.592510
Expression variation in blood from EXPOLDB for ATF2
UniProtKB/Swiss-Prot: ATF2_HUMAN, P15336
Tissue specificity: Abundant expression seen in the brain

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ATF2 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ATF2¹	--	activating transcription factor 2	96.37(n) 99.41(a)	478806 XM_535970.2 XP_535970.2
cow (Bos taurus)	ATF2¹	--	activating transcription factor 2	95.84(n) 98.61(a)	509827 XM_875924.2 XP_881017.2
rat (Rattus norvegicus)	Atf2¹	--	activating transcription factor 2	93.57(n) 98.36(a)	81647 NM_031018.1 NP_112280.1
mouse (Mus musculus)	Atf2^{1, 5}	2⁵	activating transcription factor 2^{1, 5}	94.39(n)¹ 99.18(a)¹	11909¹ NM_001025093.1¹ NP_001020264.1¹ AF483482⁵ AF483483⁵ (see all 30)
chicken (Gallus gallus)	ATF2¹	--	activating transcription factor 2	85.08(n) 93.84(a)	395727 NM_204904.1 NP_990235.1

About this table Species with no ortholog for ATF2

ENSEMBL Gene Tree for ATF2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ATF2 gene

ATF7² CREB5²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/556 NCBI SNPs in ATF2 are shown (see all 556 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 175)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs166531^1,2	A,C,F,H	175741617(+)	`CCGAGT/CCCAGC`	1	--	ng3¹		11		EU EA WA MN NA	2608
	rs10497434^1,2	A,C,F,H	175724086(+)	`TACCTT/CAGCTG`	1	--	ut5¹ ese³		12		NS NA EU EA WA	664
	rs268214^1,2	A,C,F,H	175741461(+)	`TAAACT/CCGGAG`	1	--	ng3¹		13		EU EA WA NA MN	1278
	rs268215^1,2	C,F,H	175742250(+)	`AGTACT/CGTCCC`	1	--	ng3¹		4		EU EA WA	420
	rs6759500^1,2	A,C	175742510(+)	`TTTTTA/TAAAAA`	1	--	ng3¹		0	--	--	--	--
	rs13397904^1,2	F,H	175743142(+)	`ACCTCT/CTCTTT`	1	--	ng3¹ trp³		4		EU EA WA	400
	rs13027835^1,2	H	175741643(+)	`TCTCCG/ATTTCC`	1	--	ng3¹		4		EU EA WA	418
	rs1963339^1,2	H	175647324(+)	`ATACAA/TTTTAC`	1	--	ut3¹		4		EU EA WA	410
--	rs3217492^1,2	C	175741568(+)	`AGGTG-/GTGAGCTC`	1	--	ng3¹		0	--	--	--	--
	rs13026486^1,2	H	175741157(+)	`GTCCTC/TTCTCG`	1	--	ng3¹ ese³		4		EU EA WA	420

About this table

HapMap Linkage Disequilibrium images for ATF2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 123811

10/21 Novoseek disease relationships for ATF2 gene (see all 21 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia t-cell	47.89	3	8610463 (1), 8407959 (1), 11478948 (1)
picks disease	44.28	1	16496165 (1)
necrosis	33.85	7	10318823 (2), 11234888 (1), 17804813 (1), 10521481 (1) (see all 6)
melanoma	28.60	37	14678960 (5), 10318823 (5), 11234888 (3), 9484842 (3) (see all 11)
tumors	28.02	39	18677098 (5), 11836564 (3), 11234888 (2), 10318823 (2) (see all 15)
retinoblastoma	17.99	4	11566021 (2), 7786026 (2)
adpkd	7.50	1	16049073 (1)
polycystic kidney diseases	4.46	1	16049073 (1)
breast cancer	2.98	11	11836564 (4), 16050133 (3), 17189429 (1), 12520731 (1)
insulinoma	0.05	1	8617262 (1)

About this table

1 PharmGKB disease relationship for ATF2 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872

About this table

Genetic Association Database: ATF2
Human Genome Epidemiology Navigator: ATF2 (15 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/412 PubMed articles for ATF2 gene (see all 412 ):

A cDNA for a human cyclic AMP response element-binding protein which is distinct from CREB and expressed preferentially in brain. (PubMed id 2320002)^{1, 3, 4} Kara C.J.... Glimcher L.H. (1990)
Characterization of functional domains of an embryonic stem cell coactivator UTF1 which are conserved and essential for potentiation of ATF-2 activity. (PubMed id 9748258)^{1, 3, 4} Fukushima A....Muramatsu M. (1998)
Assignment of the gene for cyclic AMP-response element binding protein 2 (CREB2) to human chromosome 2q24.1-q32. (PubMed id 1838349)^{1, 2, 3} Diep A....Lusis A.J. (1991)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
No association between a transcription factor Activating Protein 2beta (AP-2beta) gene variant and schizophrenia. (PubMed id 12270648)^{3, 6} Jonsson E.G....Sedvall G.C. (2002)
Identification of a novel, spliced variant of CREB that is preferentially expressed in the thymus. (PubMed id 9058782)^{3, 4} Yang L.... Kraig E. (1997)
Assignment of the human CREB2 (CRE-BP1) gene to 2q32. (PubMed id 1833307)^{2, 3} Ozawa K....Ishii S. (1991)
Leucine zipper structure of the protein CRE-BP1 binding to the cyclic AMP response element in brain. (PubMed id 2529117)^{3, 4} Maekawa T.... Ishii S. (1989)
Subcellular localization of activating transcription factor 2 in melanoma specimens predicts patient survival. (PubMed id 14678960)^{1, 3} Berger A.J....Rimm D.L. (2003)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 1386	HGNC: 784	AceView: ATF2	Ensembl:ENSG00000115966	euGenes: HUgn1386
ECgene: ATF2	H-InvDB: ATF2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ATF2	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for ATF2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ATF2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ATF2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ATF2		Antibodies for ATF2
	Explore super-pooled esiRNAs		Proteins for ATF2
	Lentivirus-delivered shRNAs for ATF2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ATF2)
	Antibodies (ATF2)
	Chimera RNAi (ATF2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for ATF2 (ATF-2)

	Recombinant Proteins (ATF2)
	Antibodies (ATF2)

Search OriGene for ATF2

Search Tocris compounds for ATF2

	Proteins for ATF2
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ATF2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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ATF2 Gene at Home site.
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ATF2 Gene

protein-coding GIFtS: 71

Aliases &
Descriptions
for ATF2

Summaries
for ATF2

Genomic Location
for ATF2

Proteins
for ATF2

Protein Domains/
Families
for ATF2

Gene Function
for ATF2

Pathways & Interactions
for ATF2

Drugs & Compounds
for ATF2

Transcripts
for ATF2

Expression
for ATF2

Orthologs
for ATF2

Paralogs
for ATF2

SNPs/Variants
for ATF2

Disorders & Mutations
for ATF2

Medical News
for ATF2

Publications
for ATF2

Search for ATF2

Genome Databases showing ATF2

Other Databases showing ATF2

Specialized Databases showing ATF2

Licensable Technologies
for ATF2

Services
for ATF2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ATF2 Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor ATF2

Summariesfor ATF2

Genomic Locationfor ATF2

Proteinsfor ATF2

Protein Domains/Familiesfor ATF2

Gene Functionfor ATF2

Pathways & Interactionsfor ATF2

Drugs & Compoundsfor ATF2

Transcriptsfor ATF2

Expression for ATF2

Orthologsfor ATF2

Paralogsfor ATF2

SNPs/Variantsfor ATF2

Disorders & Mutationsfor ATF2

Medical Newsfor ATF2

Publicationsfor ATF2

Search for ATF2

Genome Databases showing ATF2

Other Databases showing ATF2

Specialized Databases showing ATF2

Licensable Technologiesfor ATF2

Servicesfor ATF2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ATF2

Summaries
for ATF2

Genomic Location
for ATF2

Proteins
for ATF2

Protein Domains/
Families
for ATF2

Gene Function
for ATF2

Pathways & Interactions
for ATF2

Drugs & Compounds
for ATF2

Transcripts
for ATF2

Expression
for ATF2

Orthologs
for ATF2

Paralogs
for ATF2

SNPs/Variants
for ATF2

Disorders & Mutations
for ATF2

Medical News
for ATF2

Publications
for ATF2

Licensable Technologies
for ATF2

Services
for ATF2