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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ATF2 Gene

protein-coding GIFtS: 68
GCID: GC02M175937

activating transcription factor 2

(Previous name: cAMP responsive element binding protein 2 )
(Previous symbol: CREB2)

Explore 43 diseases affiliated with
ATF2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Activating Transcription Factor 2¹ ² ³		CAMP-Dependent Transcription Factor ATF-2² ³
CREB2¹ ² ³ ⁵		CAMP-Responsive Element-Binding Protein 2² ³
HB16¹ ² ³		CAMP Responsive Element Binding Protein 2¹
CRE-BP1¹ ²		Activating Transcription Factor 2 Splice Variant ATF2-Var2²
TREB7¹ ²		CAMP Responsive Element Binding Protein 2, Formerly²
Cyclic AMP-Responsive Element-Binding Protein 2² ³		Cyclic AMP-Dependent Transcription Factor ATF-2²
CREB-2² ³		CREBP1³
CAMP Response Element-Binding Protein CRE-BP1² ³

External Ids:	HGNC: 784¹	Entrez Gene: 1386²	Ensembl: ENSG00000115966⁷	OMIM: 123811⁵	UniProtKB: P15336³

Export aliases for ATF2 gene to outside databases

Previous GC identifers: GC02M173991 GC02M174600 GC02M175903 GC02M176141 GC02M175762 GC02M175645 GC02M167819

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ATF2:

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This

protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer

with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that

specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that

activate transcription by direct effects on chromatin components. Several alternatively spliced transcript variants

have been found for this gene. (provided by RefSeq, Jan 2012)

UniProtKB/Swiss-Prot: ATF2_HUMAN, P15336

Function: Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE)

(consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Interaction with JUN

redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as

part of an ATF2/JUN complex

Gene Wiki entry for ATF2 (Activating transcription factor 2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ATF2 gene promoter:
AREB6 FAC1 HOXA5 p300 ATF-2 ATF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ATF2 promoter sequence

Search SABiosciences Chromatin IP Primers for ATF2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATF2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32 Ensembl cytogenetic band: 2q31.1 HGNC cytogenetic band: 2q32

ATF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATF2 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M175937: view genomic region (about GC identifiers)

Start:	175,936,978 bp from pter	End:	176,033,110 bp from pter
Size:	96,133 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ATF2_HUMAN, P15336 (See protein sequence)

Recommended Name: Cyclic AMP-dependent transcription factor ATF-2

Size: 505 amino acids; 54537 Da

Subunit: Binds DNA as a dimer and can form a homodimer in the absence of DNA. Can form a heterodimer with JUN.

Interacts with SMAD3 and SMAD4. Binds through its N-terminal region to UTF1 which acts as a coactivator of ATF2

transcriptional activity

Subcellular location: Nucleus

Caution: It is uncertain whether Met-1 or Met-19 is the initiator

3 PDB 3D structures from and Proteopedia for ATF2:

1BHI (3D)

1T2K (3D)

4H36 (3D)

Secondary accessions: A1L3Z2 D3DPE9 Q13000 Q4ZFU9 Q53RY2 Q8TAR1

Alternative splicing: 3 isoforms: P15336-1 P15336-2 P15336-3

Explore the universe of human proteins at neXtProt for ATF2: NX_P15336

Post-translational modifications:

Phosphorylation of Thr-69 by MAPK14 and MAPK11, and at Thr-71 by MAPK1/ERK2, MAPK3/ERK1, MAPK11, MAPK12 and MAPK14 in

response to external stimulus like insulin causes increased transcriptional activity. Phosphorylated by PLK3 following

hyperosmotic stress. Also phosphorylated and activated by JNK and CaMK4¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P15336

ATF2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (6 alternative transcripts):

NP_001243019.1 NP_001243020.1 NP_001243021.1 NP_001243022.1 NP_001243023.1 NP_001871.2

ENSEMBL proteins:

ENSP00000264110 ENSP00000340576 ENSP00000386326 ENSP00000387093 ENSP00000406995

ENSP00000412293 ENSP00000376327 ENSP00000389504 ENSP00000402190 ENSP00000410224

ENSP00000402229 ENSP00000410086 ENSP00000386282 ENSP00000414171 ENSP00000416854

ENSP00000386526 ENSP00000444239 ENSP00000407911 ENSP00000376326 ENSP00000437952

ENSP00000443513

Reactome Protein details: P15336
Human Recombinant Protein Products for ATF2:

	EMD Millipore Purified and/or Recombinant ATF2 Protein
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	ProSpec Recombinant Protein for ATF2
	Uscn Proteins for ATF2

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005624	membrane fraction	--	--
GO:0005634	nucleus	IDA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005730	NOT nucleolus	IDA	--

ATF2 for ontologies About GeneDecksing

ATF2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of ATF2
	R&D Systems Antibodies for ATF2
	Cell Signaling Technology (CST) Antibodies for ATF2 (ATF-2)
	OriGene Antibodies (see all 5): ATF2 OriGene Custom Antibody Services for ATF2
	GenScript Superior Antibodies for ATF2
	Novus Biologicals ATF2 Antibodies
	Abcam antibodies for ATF2
	Uscn Antibodies for ATF2
	ThermoFisher Antibody for ATF2

Assay Products for ATF2:

	EMD Millipore Kits and Assays for the Analysis of ATF2
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ATF2
	Cell Signaling Technology (CST) Sandwich ELISA Kits for ATF2 (ATF-2)
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ATF2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ATF2 for domains About GeneDecksing

5 InterPro domains/families:

IPR004827 bZIP

IPR015880 Znf_C2H2-like

IPR016378 TF_cAMP-dep

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry P15336

ProtoNet protein and cluster: P15336

1 Blocks protein family: IPB011616 bZIP transcription factor

UniProtKB/Swiss-Prot: ATF2_HUMAN, P15336

Similarity: Belongs to the bZIP family. ATF subfamily

Similarity: Contains 1 bZIP (basic-leucine zipper) domain

Similarity: Contains 1 C2H2-type zinc finger

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ATF2_HUMAN, P15336

Function: Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE)

(consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Interaction with JUN

redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as

part of an ATF2/JUN complex

Genatlas biochemistry entry for ATF2:

activating transcription factor 2,cAMP response element binding protein

Gene Ontology (GO): 5/18 molecular function terms (GO ID links to tree view) (see all 18): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	IDA	19861239
GO:0001076	RNA polymerase II transcription factor binding transcription factor activity	IC	19861239
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	IEA	--
GO:0001102	RNA polymerase II activating transcription factor binding	IPI	19861239
GO:0003676	nucleic acid binding	--	--

ATF2 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for ATF2:

Decreased homologous recombina

15/20 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Atf2) (see all 20):

adipose tissue	behavior/neurological	cardiovascular system	cellular	embryogenesis
growth/size	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system
integument	limbs/digits/tail	liver/biliary system	mortality/aging	nervous system

ATF2 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for ATF2: Atf2^tm1Nicj Atf2^tm1Sis Atf2^tm1Glm

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ATF2

		10/196 SABiosciences Target genes for ATF2 (see all 196):
		AARS ACOX1 ACTL7A ACTL7B ACTN2 ADAMTS10 ADORA2B AFG3L2 AGPAT3 ANKS6

miRNA Products:		OriGene 3'-UTR Clone: ATF2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ATF2
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate ATF2 (see all 12):
		hsa-miR-623 hsa-miR-374b hsa-miR-548e hsa-miR-374a hsa-miR-1297 hsa-miR-211 hsa-miR-548a-3p hsa-miR-369-3p

		SwitchGear 3'UTR luciferase reporter plasmid: ATF2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ATF2 (see all 7) OriGene shRNA RFP: ATF2 OriGene siRNA: ATF2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ATF2
		Sirion Biotech Custom design and validation of potent shRNA sequences against ATF2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for ATF2
			Sirion Biotech Customized adenovirus for overexpression of ATF2 Sirion Biotech Customized adenovirus for potent knockdown of ATF2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATF2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATF2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ATF2 (NM_001880)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATF2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATF2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ATF2
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		Sirion Biotech Customized stable knockdown cell line services for ATF2 Sirion Biotech Customized inducible knockdown cell line services for ATF2 Sirion Biotech Customized stable overexpressing cell line services for ATF2 Sirion Biotech Customized inducible overexpressing cell line services for ATF2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATF2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/66 super-pathways (see all 66) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

TRAF6 Mediated Induction of proinflammatory cytokines

8/19 pathways (see all 19)
TRAF6 Mediated Induction of proinflammatory cytokines	1.00	Toll Like Receptor TLR1:TLR2 Cascade	0.78
MAP kinase activation in TLR cascade	0.88	Toll Like Receptor 2 (TLR2) Cascade	0.78
Toll Like Receptor 5 (TLR5) Cascade	0.86	MyD88:Mal cascade initiated on plasma membrane	0.78
Toll Like Receptor 10 (TLR10) Cascade	0.86	TRIF-mediated TLR3/TLR4 signaling	0.73

G-protein signaling_Ras family GTPases in kinase cascades (scheme)

G-protein signaling Ras family GTPases in kinase cascades (scheme)	1.00	Activation of the AP-1 family of transcription factors	0.33
G-protein signaling_Ras family GTPases in kinase cascades (scheme)	1.00	Immune response_Role of integrins in NK cells cytotoxicity	0.28
Immune response_Oncostatin M signaling via MAPK in human cells	0.39	Immune response Role of integrins in NK cells cytotoxicity	0.28
Immune response Oncostatin M signaling via MAPK in human cells	0.39

Development FGFR signaling pathway

	Development FGFR signaling pathway	1.00			Development_Flt3 signaling	0.45
	Development_FGFR signaling pathway	0.98			Development Flt3 signaling	0.45

Immune response_IL-2 activation and signaling pathway

	Immune response IL-2 activation and signaling pathway	1.00			Immune response_IL-3 activation and signaling pathway	0.41
	Immune response_IL-2 activation and signaling pathway	1.00			Immune response IL-3 activation and signaling pathway	0.41

Immune response IL-12-induced IFN-gamma production

	Immune response IL-12-induced IFN-gamma production	1.00			IL12-mediated signaling events	0.33
	Immune response_IL-12-induced IFN-gamma production	0.88

Pathway sources
See GeneCards unified pathways
Show all pathways

5/19 EMD Millipore Pathways for ATF2 (see all 19)

	Immune response CD16 signaling in NK cells
	Development A1 receptor signaling
	G-protein signaling Ras family GTPases in kinase cascades (scheme)
	Immune response IL-1 signaling pathway
	Immune response IL-2 activation and signaling pathway

1 R&D Systems Pathway for ATF2

TGF-beta Signaling Pathways

5/34 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ATF2 (see all 34)

	Toll-Like Receptors Pathway
	Antioxidant Action of Vitamin-C
	JNK Pathway
	PI3K Signaling in B-Lymphocyte
	BMP Pathway

1 Cell Signaling Technology (CST) Pathway for ATF2

MAP Kinase Signaling

5/21 GeneGo (Thomson Reuters) Pathways for ATF2 (see all 21)

	Development A2A receptor signaling
	G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
	Immune response CD16 signaling in NK cells
	Immune response IL-12-induced IFN-gamma production
	Mucin expression in CF via IL-6, IL-17 signaling pathways

5/20 BioSystems Pathways for ATF2 (see all 20)

	AGE/RAGE pathway
	Myometrial Relaxation and Contraction Pathways
	MAPK signaling pathway
	p38 MAPK Signaling Pathway
	B Cell Receptor Signaling Pathway

5/23 Reactome Pathways for ATF2 (see all 23)

	Toll Like Receptor 2 (TLR2) Cascade
	Toll Like Receptor TLR6:TLR2 Cascade
	Toll-Like Receptors Cascades
	TRAF6 Mediated Induction of proinflammatory cytokines
	Toll Like Receptor 7/8 (TLR7/8) Cascade

1 PharmGKB Pathway for ATF2

Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

2 Kegg Pathways (Kegg details for ATF2):

	MAPK signaling pathway
	Influenza A

ATF2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ATF2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/238 Interacting proteins for ATF2 (P15336^{1, 2, 3} ENSP00000264110⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 238)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
JUN	P05412¹^,²^,³, ENSP00000360266⁴	EBI-1170906,EBI-852823 MINT-6699748 MINT-6628041 I2D: score=6 STRING: ENSP00000360266
HDAC4	P56524²^,³, ENSP00000264606⁴	MINT-7555712 MINT-7555703 I2D: score=2 STRING: ENSP00000264606
CITED1	Q99966²^,³, ENSP00000388548⁴	MINT-6628046 MINT-6628051 I2D: score=1 STRING: ENSP00000388548
FOS	P01100¹^,³, ENSP00000306245⁴	EBI-1170906,EBI-852851 I2D: score=5 STRING: ENSP00000306245
MAPK11	Q15759²^,³, ENSP00000333685⁴	MINT-4789511 I2D: score=5 STRING: ENSP00000333685

About this table

Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002224	toll-like receptor signaling pathway	TAS	--
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	TAS	--
GO:0002756	MyD88-independent toll-like receptor signaling pathway	TAS	--
GO:0003151	outflow tract morphogenesis	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	--	--

ATF2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ATF2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ATF2

1 HMDB Compound for ATF2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Cyclic AMP	Cyclic AMP (see all 19)	60-92-4	--

10/43 Novoseek chemical compound relationships for ATF2 gene (see all 43) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
sb 203580	79.6	14	18028805 (2), 10082133 (1), 12093796 (1), 10201899 (1) (see all 9)
sp 600125	76.3	7	12663670 (1), 15466475 (1), 19517066 (1), 12898508 (1) (see all 7)
leucine	63.5	49	8479741 (5), 8440710 (3), 1836214 (2), 2320002 (2) (see all 20)
cyclic amp	59.9	36	1453687 (4), 20178980 (2), 10871653 (2), 8816436 (1) (see all 17)
anisomycin	57.1	2	8805335 (2)
pd 98,059	50.7	2	12663670 (1), 16050133 (1)
12-o-tetradecanoylphorbol 13-acetate	37.5	12	19176525 (3), 8020141 (1), 8440710 (1), 12592382 (1) (see all 6)
threonine	36	6	19176525 (1), 11533064 (1), 17397142 (1), 11163354 (1) (see all 6)
pge2	28.8	3	15640148 (1), 11564156 (1)
forskolin	20.4	1	14519095 (1)

Search CenterWatch for drugs/clinical trials and news about ATF2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ATF2 gene (6 alternative transcripts):

NM_001256090.1 NM_001256091.1 NM_001256092.1 NM_001256093.1 NM_001256094.1 NM_001880.3

Unigene Cluster for ATF2:

Activating transcription factor 2

Hs.592510 [show with all ESTs]

Unigene Representative Sequence: NR_045769

18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):

ENST00000264110(uc002ujl.3 uc002ujv.3 uc002ujp.3 uc002ujq.3 uc010fqu.3 uc002ujr.3 uc002ujt.3)

ENST00000345739(uc002ujm.3) ENST00000409437 ENST00000409635 ENST00000435004

ENST00000428760 ENST00000392544 ENST00000417080(uc002ujw.1 uc002ujx.1)

ENST00000456655 ENST00000421438 ENST00000429579 ENST00000415955 ENST00000409499

ENST00000478905 ENST00000435231 ENST00000437522 ENST00000409833(uc002ujy.1)

ENST00000413123

miRNA Products:		OriGene 3'-UTR Clone: ATF2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ATF2
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate ATF2 (see all 12):
		hsa-miR-623 hsa-miR-374b hsa-miR-548e hsa-miR-374a hsa-miR-1297 hsa-miR-211 hsa-miR-548a-3p hsa-miR-369-3p

		SwitchGear 3'UTR luciferase reporter plasmid: ATF2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ATF2 (see all 7) OriGene shRNA RFP: ATF2 OriGene siRNA: ATF2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ATF2
		Sirion Biotech Custom design and validation of potent shRNA sequences against ATF2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATF2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATF2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ATF2 (NM_001880)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATF2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATF2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATF2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ATF2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATF2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATF2

Additional cDNA sequence:

AF283776.2 AK128731.1 AL050192.1 AY029364.1 BC026175.1 BC107698.1 BC130335.1 BC130337.1

BX648469.1 DQ003036.1 DQ003037.1 DQ003038.1 DQ003039.1 DQ003040.1 DQ003041.1 DQ003042.1

DQ003043.1 DQ003044.1 DQ003045.1 DQ003046.1 DQ003047.1 DQ003048.1 DQ003049.1 M31630.1

NR_045768.1 NR_045769.1 NR_045770.1 NR_045771.1 NR_045772.1 NR_045773.1 NR_045774.1 X15875.1

21 DOTS entries:

DT.120968633 DT.100783893 DT.95106445 DT.100716537 DT.100783898 DT.40295835 DT.120968676 DT.120968505

DT.120968595 DT.313621 DT.120968464 DT.120968580 DT.95132221 DT.92040518 DT.92381070 DT.120968564

DT.120968630 DT.95113271 DT.120968507 DT.120968548 DT.120968730

24/167 AceView cDNA sequences (see all 167):

AW593615 BE786164 AI092519 BM312012 BF477989 AA683611 AA773979 AA151848

AW591709 BX107614 AI824548 BQ722122 BF477683 BM980871 AI191455 BM678028

AI471983 BM725921 CK821771 CK821770 AI571921 AA992382 BQ029188 AA703894

GeneLoc Exon Structure

5/17 Alternative Splicing Database (ASD) splice patterns (SP) for ATF2 (see all 17) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13a	·	13b	^	14	^	15a	·	15b	^	16	^	17a	·	17b
SP1:																					-																-
SP2:																					-																-				-
SP3:																					-		-														-				-
SP4:																					-												-				-		-		-
SP5:											-		-								-																-		-		-

ECgene alternative splicing isoforms for ATF2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ATF2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGTAAACCAT

About this image

ATF2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Cartilage

Rostral Synchondroses

Bone, Cartilage

Bone, Cartilage

Bone, Cartilage

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ATF2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ATF2

SOURCE GeneReport for Unigene cluster: Hs.592510

UniProtKB/Swiss-Prot: ATF2_HUMAN, P15336

Tissue specificity: Abundant expression seen in the brain

SABiosciences Expression via Pathway-Focused PCR Arrays including ATF2 (see all 6):

Epigenetic Chromatin Modification Enzymes in human mouse rat

Cancer Drug Targets in human mouse rat

NFKB Signaling Pathway in human mouse rat

EGF / PDGF Signaling Pathway in human mouse rat

Transcription Factors in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ATF2 gene from 5/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ATF2¹	activating transcription factor 2	85.08(n) 93.84(a)		395727 NM_204904.1 NP_990235.1
lizard (Anolis carolinensis)	Reptilia	ATF2⁶	--	93(a)	1 ↔ 1	GL343377.1(380857-440707)
African clawed frog (Xenopus laevis)	Amphibia	atf2-A²	activating transcription factor 2	94.47(n)		U16158.1
zebrafish (Danio rerio)	Actinopterygii	atf2¹	activating transcription factor 2	67.22(n) 74.48(a)		100006516 XM_001345201.4 XP_001345237.4
honey bee (Apis mellifera)	Insecta	--	--	24(a)	1 → many	Group13.2(464747-466871)

ENSEMBL Gene Tree for ATF2 (if available)
TreeFam Gene Tree for ATF2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ATF2 gene

ENSG00000267281² ATF7² CREB5²

3 SIMAP similar genes for ATF2 using alignment to 19 protein entries: ATF2_HUMAN (see all proteins):

CREB5 ATF7 ATF3

ATF2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs148029544^1,2		--	175936501(+)	`CTTGAC/TGGACT`	12	--	ds500¹		0	--	--	--	--
rs140810180^1,2		--	175936943(+)	`TGATGC/TTACTT`	12	--	ds500¹		0	--	--	--	--
rs150145569^1,2		--	175937191(+)	`TTACAA/GTGAAA`	12	--	ut3¹ nc-transcript-variant		0	--	--	--	--
rs138423213^1,2		--	175937255(+)	`TGTAGC/TTTTAT`	12	--	nc-transcript-variantut3¹		0	--	--	--	--
rs141685111^1,2		--	175937394(+)	`AAAAAC/TAGCCT`	12	--	ut3¹ nc-transcript-variant		0	--	--	--	--
rs116222057^1,2	C,F	--	175937495(+)	`AATGAA/TATTAG`	12	--	nc-transcript-variantut3¹		1		WA	118
rs186084026^1,2		--	175937517(+)	`AAATTA/TAAAAA`	12	--	nc-transcript-variantut3¹		0	--	--	--	--
rs145241336^1,2		--	175937618(+)	`ATAATC/TTGAAT`	12	--	nc-transcript-variantut3¹		0	--	--	--	--
rs35507277^1,2	C	--	175937662(+)	`TTTCCG/TTGAAT`	12	--	ut3¹ nc-transcript-variant		1		NA	2
rs189549380^1,2		--	175937885(+)	`TCTACC/TACTTT`	12	--	nc-transcript-variantut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ATF2 (175936978 - 176033110 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ATF2: --

SABiosciences Cancer Mutation PCR Assays

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DNA2.0 Custom Variant and Variant Library Synthesis for ATF2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ATF2 for disorders           About GeneDecksing

OMIM gene information: 123811    OMIM disorders: --

20/43 diseases for ATF2 (see all 43):    About MalaCards

eccrine porocarcinoma human t-cell leukemia virus type 1 polycystic kidney disease wegener's granulomatosis

pick's disease hypochondroplasia kidney disease basal cell carcinoma

fanconi's anemia insulinoma ulcerative colitis angiosarcoma

squamous cell carcinoma chondrodysplasia cystitis t-cell leukemia

alzheimer's disease rheumatoid arthritis neurodegeneration retinoblastoma

10/22 Novoseek disease relationships for ATF2 gene (see all 22) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia t-cell	46.3	3	8610463 (1), 8407959 (1), 11478948 (1)
picks disease	42.6	1	16496165 (1)
necrosis	32.2	7	10318823 (2), 11234888 (1), 17804813 (1), 10521481 (1) (see all 6)
melanoma	31	37	14678960 (5), 10318823 (5), 11234888 (3), 9484842 (3) (see all 11)
tumors	26.9	39	18677098 (5), 11836564 (3), 11234888 (2), 10318823 (2) (see all 15)
retinoblastoma	15.9	4	11566021 (2), 7786026 (2)
adpkd	5.08	1	16049073 (1)
polycystic kidney diseases	1.98	1	16049073 (1)
glioma	1.16	3	15488325 (2)
insulinoma	0	1	8617262 (1)

Genetic Association Database (GAD): ATF2
Human Genome Epidemiology (HuGE) Navigator: ATF2 (25 documents)

Export disorders for ATF2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ATF2 gene, integrated from 9 sources (see all 509):
(articles sorted by number of sources associating them with ATF2)

Utopia: connect your pdf to the dynamic
world of online information

A cDNA for a human cyclic AMP response element-binding protein which is distinct from CREB and expressed preferentially in brain. (PubMed id 2320002)^{1, 2, 9} Kara C.J.... Glimcher L.H. (1990)
Characterization of functional domains of an embryonic stem cell coactivator UTF1 which are conserved and essential for potentiation of ATF-2 activity. (PubMed id 9748258)^{1, 2, 9} Fukushima A....Muramatsu M. (1998)
Assignment of the gene for cyclic AMP-response element binding protein 2 (CREB2) to human chromosome 2q24.1-q32. (PubMed id 1838349)^{1, 3, 9} Diep A....Lusis A.J. (1991)
Hyperosmotic stress-induced ATF-2 activation through Polo-like kinase 3 in human corneal epithelial cells. (PubMed id 21098032)^{1, 2} Wang L....Lu L. (2011)
No association between a transcription factor Activating Protein 2beta (AP-2beta) gene variant and schizophrenia. (PubMed id 12270648)^{1, 4} Jonsson E.G....Sedvall G.C. (2002)
Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38. (PubMed id 12110590)^{1, 2} Ouwens D.M....van Dam H. (2002)
Identification of a novel, spliced variant of CREB that is preferentially expressed in the thymus. (PubMed id 9058782)^{1, 2} Yang L.... Kraig E. (1997)
Assignment of the human CREB2 (CRE-BP1) gene to 2q32. (PubMed id 1833307)^{1, 3} Ozawa K....Ishii S. (1991)
Leucine zipper structure of the protein CRE-BP1 binding to the cyclic AMP response element in brain. (PubMed id 2529117)^{1, 2} Maekawa T.... Ishii S. (1989)
Ubiquitination and degradation of ATF2 are dimerization dependent. (PubMed id 10207054)^{1, 9} Fuchs S.Y. and Ronai Z. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1386	HGNC: 784	AceView: ATF2	Ensembl:ENSG00000115966	euGenes: HUgn1386
ECgene: ATF2	Kegg: 1386	H-InvDB: ATF2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ATF2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ATF2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for ATF2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ATF2 gene:
Search GeneIP for patents involving ATF2

GeneCards and IP:
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activating transcription factor 2

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