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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ATF1 Gene

protein-coding   GIFtS: 70
GCID: GC12P051189

Activating Transcription Factor 1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Activating Transcription Factor 11 2 3     FUS/ATF-12
CAMP-Dependent Transcription Factor ATF-12 3     Cyclic AMP-Dependent Transcription Factor ATF-12
TREB362 5     Protein TREB363
EWS-ATF12     

External Ids:    HGNC: 7831   Entrez Gene: 4662   Ensembl: ENSG000001232687   OMIM: 1238035   UniProtKB: P188463   

Export aliases for ATF1 gene to outside databases

Previous GC identifers: GC12P051390 GC12P050874 GC12P049444 GC12P048190


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ATF1 Gene:
This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region
leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream
target genes, which are related to growth, survival, and other cellular activities. This protein is
phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein
kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and
cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional
activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome
22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell
sarcoma. This gene has a pseudogene on chromosome 6. (provided by RefSeq, Aug 2010)

GeneCards Summary for ATF1 Gene: 
ATF1 (activating transcription factor 1) is a protein-coding gene. Diseases associated with ATF1 include clear cell sarcoma, and histiocytoma, and among its related super-pathways are MAP kinase activation in TLR cascade and Activation of cAMP-Dependent PKA. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is CREB1.

UniProtKB/Swiss-Prot: ATF1_HUMAN, P18846
Function: This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence
present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates
PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant
detoxification genes. Triggers cell proliferation and transformation

Gene Wiki entry for ATF1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ATF1 gene promoter:
         TBP   ATF-2   TFIID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATF1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ATF1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q13

ATF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATF1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P051189:  view genomic region     (about GC identifiers)

Start:
51,157,493 bp from pter      End:
51,214,943 bp from pter
Size:
57,451 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ATF1_HUMAN, P18846 (See protein sequence)
Recommended Name: Cyclic AMP-dependent transcription factor ATF-1  
Size: 271 amino acids; 29233 Da
Subunit: Binds DNA as a dimer. Interacts with HIPK2 and CDK3
Subcellular location: Nucleus
Sequence caution: Sequence=CAC15058.1; Type=Erroneous initiation;
Secondary accessions: P25168 Q9H4A8

Explore the universe of human proteins at neXtProt for ATF1: NX_P18846

Explore proteomics data for ATF1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated at Ser-198 by HIPK2 in response to genotoxic stress. This phosphorylation promotes transcription
    repression of FTH1 and other antioxidant detoxification genes. The CDK3-mediated phosphorylation at Ser-63
    promotes its transactivation and transcriptional activities. Phosphorylated at Ser-63 by RPS6KA4 and RPS6KA5 in
    response to mitogenic or stress stimuli
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P18846

  • ATF1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ATF1 Protein Expression
    REFSEQ proteins: NP_005162.1  
    ENSEMBL proteins: 
     ENSP00000448592   ENSP00000448421   ENSP00000262053   ENSP00000448987   ENSP00000448921  
     ENSP00000438403  
    Reactome Protein details: P18846
    Human Recombinant Protein Products for ATF1: 
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    Novus Biologicals ATF1 Proteins
    Novus Biologicals ATF1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for ATF1
    Cloud-Clone Corp. Proteins for ATF1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA8798441
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IEA--

    ATF1 for ontologies           About GeneDecksing



    ATF1 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for ATF1 

    Assay Products for ATF1: 
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    Cloud-Clone Corp. ELISAs for ATF1 
    Cloud-Clone Corp. CLIAs for ATF1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    bZIP: basic leucine zipper proteins

    3 InterPro protein domains:
     IPR004827 bZIP
     IPR003102 Coactivator_CBP_pKID
     IPR001630 Leuzip_CREB

    Graphical View of Domain Structure for InterPro Entry P18846

    ProtoNet protein and cluster: P18846

    2 Blocks protein domains:
    IPB001630 cAMP response element binding (CREB) protein signature
    IPB011616 bZIP transcription factor


    UniProtKB/Swiss-Prot: ATF1_HUMAN, P18846
    Similarity: Belongs to the bZIP family. ATF subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain
    Similarity: Contains 1 KID (kinase-inducible) domain


    ATF1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATF1_HUMAN, P18846
    Function: This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence
    present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates
    PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant
    detoxification genes. Triggers cell proliferation and transformation

         Genatlas biochemistry entry for ATF1:
    activating transcription factor,cAMP regulated,mediating the E1A responsiveness and heterodimerizing with members
    of the JUN/FOS family,ubiquitous,with main expression in hippocampus and dentate gyrus,involved in malignant
    melanoma of soft tissues with translocation t(12;22)(q13;q12) (see EWSR1)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI10722738
    GO:0043565sequence-specific DNA binding IEA--
         
    ATF1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ATF1:
     Increased S DNA content 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Atf1):
     cellular  embryogenesis  immune system  mortality/aging  nervous system 
     normal 

    ATF1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ATF1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ATF1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ATF1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ATF1 

    miRNA
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    hsa-miR-30c hsa-miR-30d hsa-miR-410 hsa-miR-340 hsa-miR-192 hsa-miR-548m hsa-miR-9 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidATF1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATF1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ATF1 About   (see all 33)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1TRAF6 Mediated Induction of proinflammatory cytokines
    Toll Like Receptor 5 (TLR5) Cascade0.93
    MyD88-independent cascade 0.87
    MyD88 cascade initiated on plasma membrane0.93
    Toll Like Receptor 3 (TLR3) Cascade0.87
    Toll Like Receptor 10 (TLR10) Cascade0.93
    Toll Like Receptor 4 (TLR4) Cascade0.87
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation0.93
    Toll-Like Receptors Cascades0.87
    2Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    3Rho Family GTPases
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    4ErbB4 Pathway
    LPS Stimulated MAPK Signaling0.47
    PI3K Signaling in B-Lymphocyte0.35
    PACAP Signaling0.37
    5ERK/MAPK targets
    Nuclear Events (kinase and transcription factor activation)0.88
    MAPK targets/ Nuclear events mediated by MAP kinases0.80

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for ATF1
        Development EDNRB signaling
    Development Thrombopoietin-regulated cell processes
    DNA damage Role of Brca1 and Brca2 in DNA repair

    1 R&D Systems Pathway for ATF1
        TGF-beta Signaling Pathways

    5/18 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ATF1 (see all 18)
        MAPK Signaling
    PKA Signaling
    BRCA1 Pathway
    PI3K Signaling in B-Lymphocyte
    PACAP Signaling

    4 GeneGo (Thomson Reuters) Pathways for ATF1
        DNA damage Role of Brca1 and Brca2 in DNA repair
    Beta-2 adrenergic-dependent CFTR expression
    Development EDNRB signaling
    Development Thrombopoietin-regulated cell processes

    5/9 BioSystems Pathways for ATF1 (see all 9)
        Myometrial Relaxation and Contraction Pathways
    EGFR1 Signaling Pathway
    Serotonin Receptor 4/6/7 and NR3C Signaling
    Integrated Breast Cancer Pathway
    IL-3 Signaling Pathway

    5/27        Reactome Pathways for ATF1 (see all 27)
        CREB phosphorylation
    Toll Like Receptor 2 (TLR2) Cascade
    Toll Like Receptor TLR6:TLR2 Cascade
    Toll-Like Receptors Cascades
    TRAF6 Mediated Induction of proinflammatory cytokines


    2         Kegg Pathways  (Kegg details for ATF1):
        HTLV-I infection
    Transcriptional misregulation in cancer


    ATF1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ATF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    5/31 Interacting proteins for ATF1 (P188462, 3 ENSP000002620534) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000224774P678703, ENSP000004156154I2D: score=1 STRING: ENSP00000415615
    CSNK2BP678703I2D: score=1 
    ENSG00000206406P678703I2D: score=1 
    ENSG00000224398P678703I2D: score=1 
    ENSG00000228875P678703I2D: score=1 
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----

    ATF1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ATF1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ATF1

    1 HMDB Compound for ATF1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    10/19 Novoseek inferred chemical compound relationships for ATF1 gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cyclic amp 68 32 7776975 (3), 9489722 (2), 10706690 (2), 7730336 (1) (see all 14)
    leucine 52.9 8 2196176 (1), 14713288 (1), 10525188 (1), 9685505 (1) (see all 7)
    forskolin 44.7 1 11526505 (1)
    sb 203580 38 1 11243876 (1)
    (+-)-pgf2-alpha 37.3 3 15913451 (2), 15710429 (1)
    oligonucleotide 32.1 2 7779811 (1), 8294429 (1)
    12-o-tetradecanoylphorbol 13-acetate 32 1 12489106 (1)
    okadaic acid 19.8 1 12489106 (1)
    adenylate 12.1 2 16306050 (1), 10697414 (1)
    glucose 4.22 1 12846747 (1)

    Search CenterWatch for drugs/clinical trials and news about ATF1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ATF1 gene: 
    NM_005171.4  

    Unigene Cluster for ATF1:

    Activating transcription factor 1
    Hs.648565  [show with all ESTs]
    Unigene Representative Sequence: NM_005171
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000552510 ENST00000549612 ENST00000262053(uc001rww.4 uc010smu.2)
    ENST00000551831 ENST00000552487 ENST00000539132
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATF1

    Additional mRNA sequence: 

    AK313406.1 BC029619.1 

    9 DOTS entries:

    DT.110842  DT.100768094  DT.95154366  DT.97823676  DT.121165334  DT.100768095  DT.121165341  DT.91725266 
    DT.91755802 

    24/118 AceView cDNA sequences (see all 118):

    AA416928 BX102171 AA173511 BQ015538 AA286945 CA424161 AI498334 CR624071 
    CR622614 NM_005171 BM766993 AA528209 BX646978 BI712419 AU280122 BF516566 
    BI754311 BG111947 BX380829 BV179619 AI915422 BM662307 BU069921 AA286980 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ATF1 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10
    SP1:                    -           -     -                                                   
    SP2:                                -     -                                                   
    SP3:                    -           -                                                         
    SP4:        -     -     -           -     -                                                   
    SP5:                    -                 -                                                   


    ECgene alternative splicing isoforms for ATF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ATF1 expression in normal human tissues (normalized intensities)      ATF1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGGAGTAT
    ATF1 Expression
    About this image


    ATF1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/30 selected tissues (see all 30) fully expand
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Uterus (Reproductive System)    fully expand to see all 3 entries
             uterus, pre-menopause ; glandular cells   
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; squamous epithelial cells   

    See ATF1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ATF1

    SOURCE GeneReport for Unigene cluster: Hs.648565
        SABiosciences Expression via Pathway-Focused PCR Arrays including ATF1: 
              NFKB Signaling Pathway in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              Transcription Factors in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ATF1 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atf11 , 5 activating transcription factor 11, 5 86.74(n)1
    91.82(a)1
      15 (56.22 cM)5
    119081  NM_007497.31  NP_031523.31 
     1002278195 
    chicken
    (Gallus gallus)
    Aves ATF11 activating transcription factor 1 79.43(n)
    87.36(a)
      426873  XM_424481.3  XP_424481.3 
    lizard
    (Anolis carolinensis)
    Reptilia ATF16
    Uncharacterized protein
    67(a)
    1 ↔ 1
    2(91108479-91132965)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL898881.22   -- 72.66(n)    AL898881.2 
    zebrafish
    (Danio rerio)
    Actinopterygii atf11 activating transcription factor 1 67.25(n)
    74.24(a)
      325609  NM_199723.1  NP_956017.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CrebB-17A6
    Cyclic-AMP response element binding protein B at 1...
    17(a)
    1 → many
    X(18260733-18271897)
    worm
    (Caenorhabditis elegans)
    Secernentea crh-16
    Protein CRH-1, isoform c
    16(a)
    1 → many
    III(11657738-11693837)


    ENSEMBL Gene Tree for ATF1 (if available)
    TreeFam Gene Tree for ATF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ATF1 gene
    CREB12  CREM2  
    18/83 SIMAP similar genes for ATF1 using alignment to 6 protein entries:     ATF1_HUMAN (see all proteins) (see all similar genes):
    EWSR1/ATF1 fusion    BEAN1    CREB1    IRF2    AAR2    HINFP
    TMEM78    PACRG    PPP2R5C    SLC35E3    LOC100996426    PFKFB3
    CDK10    NEK4    PTPLAD1    pp12301    ABI2    ADCK1

    ATF1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ATF1
    PGOHUM00000243295


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1144 SNPs in ATF1 are shown (see all 1144)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1931506311,2
    --50989603(+) CAACAA/TCTGCC 1 -- us2k10--------
    rs1388161431,2
    --50989740(+) GTCTCA/GAACTC 1 -- us2k10--------
    rs108760811,2
    C,A--50989747(+) ACTCCC/TGACCT 1 -- us2k1 tfbs30--------
    rs1152714871,2
    F--50989793(+) GGAATT/AACAGT 1 -- us2k11Minor allele frequency- A:0.09WA 118
    rs1857082481,2
    --50989825(+) CCTCCC/TCCGCT 1 -- us2k10--------
    rs1902321071,2
    --50989889(+) AACACC/TAAAGA 1 -- us2k10--------
    rs1913551701,2
    --50989922(+) CTTCCA/GGCCAT 1 -- us2k10--------
    rs1835329171,2
    --50990036(+) TTTCAC/GTAATG 1 -- us2k10--------
    rs1160089561,2
    F--50990069(+) GTTGTC/ACCCTG 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1463306651,2
    --50990142(+) CTCTTA/GAGACT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ATF1 (51157493 - 51214943 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ATF1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv899078CNV Loss21882294
    nsv899077CNV Loss21882294


    Human Gene Mutation Database (HGMD): ATF1
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 123803    OMIM disorders: --

    UniProtKB/Swiss-Prot: ATF1_HUMAN, P18846
  • Angiomatoid fibrous histiocytoma (AFH) [MIM:612160]: A distinct variant of malignant fibrous histiocytoma
    that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic
    microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of
    hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a
    lymph node metastasis. Note=The gene represented in this entry may be involved in disease pathogenesis.
    Chromosomal aberrations involving ATF1 are found in patients with angiomatoid fibrous histiocytoma. Translocation
    t(12;16)(q13;p11.2) with FUS generates a chimeric ATF1/FUS protein. Translocation t(12;22)(q13;q12) with EWSR1
    generates a chimeric ATF1/EWSR1 protein

  • 20/36 diseases for ATF1 (see all 36):    About MalaCards
    clear cell sarcoma    histiocytoma    fibrous histiocytoma    gdnf-related hirschsprung disease
    vulvar melanoma    melanoma of soft part    hirschsprung's disease    peripheral primitive neuroectodermal tumor
    steroid-resistant nephrotic syndrome    liposarcoma    blastoma    myxoid liposarcoma
    primitive neuroectodermal tumor    human t-cell leukemia virus type 1    nephrotic syndrome    sarcoma
    sporadic breast cancer    melanoma    chronic myeloid leukemia    esophageal adenocarcinoma

    4 diseases from the University of Copenhagen DISEASES database for ATF1:
    Sarcoma     Vulvar melanoma     Peripheral primitive neuroectodermal tumor     Myxoid liposarcoma

    ATF1 for disorders           About GeneDecksing

    10/21 Novoseek inferred disease relationships for ATF1 gene (see all 21)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sarcoma clear cell 89.5 14 17000668 (1), 7493135 (1), 20362353 (1), 16285301 (1) (see all 11)
    histiocytoma fibrous 66.7 4 11063792 (1), 18300800 (1), 12915480 (1), 15884099 (1)
    ewings sarcoma 62 13 15150091 (1), 7493135 (1), 10766345 (1), 12021921 (1) (see all 9)
    liposarcoma myxoid 50.7 3 7493135 (1), 11063792 (1), 12915480 (1)
    carcinoma embryonal 48.2 2 7687341 (1), 7843287 (1)
    melanoma 48 13 16306050 (1), 7829090 (1), 10766345 (1), 16285301 (1) (see all 11)
    metastatic melanoma 43.6 4 16306050 (1), 19308689 (1), 10851072 (1)
    sarcoma 41.5 5 12721254 (1), 9160316 (1), 17724745 (1)
    tumors 29 12 17409099 (2), 16306050 (1), 7829090 (1), 7493135 (1) (see all 11)
    neoplastic transformation 22.7 3 15706412 (1), 10874008 (1), 12506033 (1)

    Genetic Association Database (GAD): ATF1
    Human Genome Epidemiology (HuGE) Navigator: ATF1 (23 documents)

    Export disorders for ATF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ATF1 gene, integrated from 9 sources (see all 261):
    (articles sorted by number of sources associating them with ATF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A. (PubMed id 1655749)1, 2, 9 Rehfuss R.P.... Goodman R.H. (1991)
    2. EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts. (PubMed id 8401579)1, 3, 9 Zucman J....Thomas G. (1993)
    3. Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain. (PubMed id 2196176)1, 2, 9 Yoshimura T....Yoshida M. (1990)
    4. Fusion of the EWSR1 and ATF1 genes without expression of the MITF-M transcript in angiomatoid fibrous histiocytoma. (PubMed id 15884099)1, 2, 9 Hallor K.H.... Panagopoulos I. (2005)
    5. GWAS for discovery and replication of genetic loci as sociated with sudden cardiac arrest in patients with coronary artery disease. (PubMed id 21658281)1, 4 Aouizerat B.E....Tseng Z.H. (2011)
    6. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (2010)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    8. Genetic variation in genes interacting with BRCA1/2 a nd risk of breast cancer in the Cypriot population. (PubMed id 19714462)1, 4 Loizidou M.A....Kyriacou K. (2010)
    9. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1, 4 Vega A....Carracedo A. (2009)
    10. Single nucleotide polymorphisms in miRNA binding site s and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk w omen. (PubMed id 19950226)1, 4 Kontorovich T....Friedman E. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 466 HGNC: 783 AceView: ATF1 Ensembl:ENSG00000123268 euGenes: HUgn466
    ECgene: ATF1 Kegg: 466 H-InvDB: ATF1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ATF1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ATF1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ATF1 gene:
    Search GeneIP for patents involving ATF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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