ATF1 Gene
protein-coding GIFtS: 66
GCID: GC12P051189
|
|
activating transcription factor 1
| |
Aliases
for ATF1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Activating Transcription Factor 11 2 3 | | FUS/ATF-12 | | TREB361 2 5 | | Cyclic AMP-Dependent Transcription Factor ATF-12 | | CAMP-Dependent Transcription Factor ATF-12 3 | | Protein TREB363 | | EWS-ATF12 | | |
Export aliases for ATF1 gene to outside databasesPrevious GC identifers: GC12P051390 GC12P050874 GC12P049444 GC12P048190 |
Summaries
for ATF1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ATF1:
This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucinezipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes,which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 inits kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent proteinkinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylationenhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene andFUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoidfibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. (provided by RefSeq, Aug2010)
UniProtKB/Swiss-Prot: ATF1_HUMAN, P18846Function: This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present inmany viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-inducedstimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes.Triggers cell proliferation and transformation
Gene Wiki entry for ATF1
|
Genomic Views
for ATF1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ATF1 gene promoter:
TBP ATF-2 TFIID
Other transcription factors
Search SABiosciences Chromatin IP Primers for ATF1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATF1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13 Ensembl cytogenetic band: 12q13.12 HGNC cytogenetic band: 12q13ATF1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P051189: view genomic region
(about GC identifiers)
Start:
|
51,157,493 bp from pter |
End:
|
51,214,943 bp from pter |
Size:
|
57,451 bases |
Orientation:
|
plus strand |
|
Proteins
for ATF1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ATF1_HUMAN, P18846 (See
protein sequence)Recommended Name: Cyclic AMP-dependent transcription factor ATF-1 Size: 271 amino acids; 29233 Da
Subunit: Binds DNA as a dimer. Interacts with HIPK2 and CDK3
Subcellular location: Nucleus
Sequence caution: Sequence=CAC15058.1; Type=Erroneous initiation;
Secondary accessions: P25168 Q9H4A8Explore the universe of human proteins at neXtProt for ATF1: NX_P18846
Post-translational modifications:
Phosphorylated at Ser-198 by HIPK2 in response to genotoxic stress. This phosphorylation promotes transcriptionrepression of FTH1 and other antioxidant detoxification genes. The CDK3-mediated phosphorylation at Ser-63 promotesits transactivation and transcriptional activities. Phosphorylated at Ser-63 by RPS6KA4 and RPS6KA5 in response tomitogenic or stress stimuli1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P18846
ATF1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005162.1
ENSEMBL proteins: ENSP00000448592 ENSP00000448421 ENSP00000262053 ENSP00000448987 ENSP00000448921 ENSP00000438403 Reactome Protein details: P18846
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
ATF1 for ontologies About GeneDecksing
ATF1 Antibody Products:
Assay Products for ATF1: |
Protein
Domains /
Families
for ATF1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ATF1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P18846ProtoNet protein and cluster: P18846 2 Blocks protein families: IPB001630 cAMP response element binding (CREB) protein signature IPB011616 bZIP transcription factor
UniProtKB/Swiss-Prot: ATF1_HUMAN, P18846Similarity: Belongs to the bZIP family. ATF subfamilySimilarity: Contains 1 bZIP (basic-leucine zipper) domainSimilarity: Contains 1 KID (kinase-inducible) domain |
Function
for ATF1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ATF1_HUMAN, P18846Function: This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present inmany viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-inducedstimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes.Triggers cell proliferation and transformation Genatlas biochemistry entry for ATF1:activating transcription factor,cAMP regulated,mediating the E1A responsiveness and heterodimerizing with members ofthe JUN/FOS family,ubiquitous,with main expression in hippocampus and dentate gyrus,involved in malignant melanoma ofsoft tissues with translocation t(12;22)(q13;q12) (see EWSR1)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATF1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATF1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ATF1 (NM_005171) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ATF1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATF1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATF1 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
-- | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0003705 | RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity |
-- | -- | | GO:0010843 | promoter binding |
-- | -- | | GO:0032403 | protein complex binding |
-- | -- |
ATF1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ATF1:
Animal Models:
5 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Atf1):
ATF1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for ATF1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/31 super-pathways (see all 31) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | TRAF6 Mediated Induction of proinflammatory cytokines | | | 2 | Activation of cAMP-Dependent PKA | | | 3 | Rho Family GTPases | | | 4 | Immune System | | | 5 | ERK/MAPK targets | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 EMD Millipore Pathways for ATF1
1  R&D Systems Pathway for ATF1
5/18 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ATF1 (see all 18)
4  GeneGo (Thomson Reuters) Pathways for ATF1
5/8  BioSystems Pathways for ATF1 (see all 8)
5/27 
Reactome Pathways for ATF1 (see all 27)
ATF1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ATF1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 21)
5/26 Interacting proteins for ATF1 (P188462, 3 ENSP000002620534) via UniProtKB, MINT, STRING, and/or I2D (see all 26)About this table
Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0002224 | toll-like receptor signaling pathway |
TAS | -- | | GO:0002755 | MyD88-dependent toll-like receptor signaling pathway |
TAS | -- | | GO:0002756 | MyD88-independent toll-like receptor signaling pathway |
TAS | -- | | GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- |
ATF1 for ontologies About GeneDecksing
|
Drugs & Compounds
for ATF1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ATF1 for compounds About GeneDecksing
 Browse Tocris compounds for ATF1
1 HMDB Compound for ATF1 About this table
10/19 Novoseek chemical compound relationships for ATF1 gene (see all 19) About this table
Search CenterWatch for drugs/clinical trials and news about ATF1
|
Transcripts
for ATF1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ATF1 gene: NM_005171.4 Unigene Cluster for ATF1: Activating transcription factor 1 Hs.648565 [show with all ESTs]Unigene Representative Sequence: NM_0051716 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000552510 ENST00000549612 ENST00000262053(uc001rww.4 uc010smu.2)
ENST00000551831 ENST00000552487 ENST00000539132
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATF1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATF1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ATF1 (NM_005171) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ATF1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATF1 |
Additional cDNA sequence: AK313406.1 BC029619.1 9 DOTS entries: DT.110842 DT.100768094 DT.95154366 DT.97823676 DT.121165334 DT.100768095 DT.121165341 DT.91725266 DT.91755802 24/118 AceView cDNA sequences (see all 118): BQ015538 CR624071 BX102171 AI498334 AA286945 CR622614 NM_005171 CA424161 AA173511 BM766993 AA416928 BX392004 AW575133 BG496501 AL546447 H54541 AA528209 AA376809 BQ024737 BE616960 BU069921 CD103623 BV179619 AA286980
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ATF1 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 |
|---|
|
| SP1: | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | - | | - | | - | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ATF1
|
Expression
for ATF1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ATF1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATGGAGTAT
About this image
See ATF1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ATF1
SOURCE GeneReport for Unigene cluster: Hs.648565
SABiosciences Expression via Pathway-Focused PCR Arrays including ATF1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATF1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ATF1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATF1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATF1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATF1 |
Orthologs
for ATF1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ATF1 gene from 6/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ATF11 |
activating transcription factor 1 |
79.43(n)
87.36(a) |
|
426873 XM_424481.3 XP_424481.3 |
lizard
(Anolis carolinensis) |
Reptilia |
ATF16 |
-- |
73(a) |
1 ↔ 1 |
2(91112242-91123015) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
AL898881.22 |
-- |
72.66(n) |
|
AL898881.2 |
zebrafish
(Danio rerio) |
Actinopterygii |
atf11 |
activating transcription factor 1 |
67.25(n)
74.24(a) |
|
325609 NM_199723.1 NP_956017.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CrebB-17A6 |
Cyclic-AMP response element binding protein B at 1... |
20(a) |
possible ortholog |
X(18260733-18271897) |
worm
(Caenorhabditis elegans) |
Secernentea |
crh-16 |
CREB Homolog family member (crh-1) |
18(a) |
possible ortholog |
III(11657638-11693737) |
ENSEMBL Gene Tree for ATF1 (if available)
TreeFam Gene Tree for ATF1 (if available) |
Paralogs
for ATF1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ATF1 gene
- CREB12 CREM2
18/76 SIMAP similar genes for ATF1 using alignment to 6 protein entries: ATF1_HUMAN (see all proteins)
(see all similar genes):EWSR1/ATF1 fusion BEAN1 CREB1 IRF2 AAR2 HINFP
TMEM78 PPP2R5C SLC35E3 NCKAP1L PFKFB3 CDK10
NEK4 PTPLAD1 pp12301 ABI2 ADCK1 TBCB
ATF1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ATF1
PGOHUM00000243295
|
Genomic Variants
for ATF1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ATF1 (51157493 - 51214943 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ATF1: --
Human Gene Mutation Database (HGMD): ATF1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ATF1 |
|
Disorders
/ Diseases
for ATF1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ATF1 for disorders About GeneDecksing
OMIM gene information: 123803
OMIM disorders: --
UniProtKB/Swiss-Prot: ATF1_HUMAN, P18846
Defects in ATF1 may be a cause of angiomatoid fibrous histiocytoma (AFH) [MIM:612160]. A distinct variant ofmalignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodularsubcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimatelyassociated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatorycells, mimicking a lymph node metastasis. Note=Chromosomal aberrations involving ATF1 are found in patients withangiomatoid fibrous histiocytoma. Translocation t(12;16)(q13;p11.2) with FUS generates a chimeric ATF1/FUS protein.Translocation t(12;22)(q13;q12) with EWSR1 generates a chimeric ATF1/EWSR1 protein
20/40  diseases for ATF1 (see all 40): About MalaCardsfibrous histiocytoma clear cell sarcoma histiocytoma sarcoma
steroid-resistant nephrotic syndrome human t-cell leukemia virus type 1 primitive neuroectodermal tumor peripheral primitive neuroectodermal tumor
malignant fibrous histiocytoma myxoid liposarcoma neuroectodermal tumors liposarcoma
nephrotic syndrome sporadic breast cancer breast-ovarian cancer chronic myeloid leukemia
blastoma myeloid leukemia adrenocortical tumor cystic fibrosis
4 diseases from the University of Copenhagen DISEASES database for ATF1:Sarcoma Vulvar melanoma Peripheral primitive neuroectodermal tumor Myxoid liposarcoma 10/21 Novoseek disease relationships for ATF1 gene (see all 21) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| sarcoma clear cell |
89.5 |
14 |
17000668 (1), 7493135 (1), 20362353 (1), 16285301 (1) (see all 11) |
| histiocytoma fibrous |
66.7 |
4 |
11063792 (1), 18300800 (1), 12915480 (1), 15884099 (1) |
| ewings sarcoma |
62 |
13 |
15150091 (1), 7493135 (1), 10766345 (1), 12021921 (1) (see all 9) |
| liposarcoma myxoid |
50.7 |
3 |
7493135 (1), 11063792 (1), 12915480 (1) |
| carcinoma embryonal |
48.2 |
2 |
7687341 (1), 7843287 (1) |
| melanoma |
48 |
13 |
16306050 (1), 7829090 (1), 10766345 (1), 16285301 (1) (see all 11) |
| metastatic melanoma |
43.6 |
4 |
16306050 (1), 19308689 (1), 10851072 (1) |
| sarcoma |
41.5 |
5 |
12721254 (1), 9160316 (1), 17724745 (1) |
| tumors |
29 |
12 |
17409099 (2), 16306050 (1), 7829090 (1), 7493135 (1) (see all 11) |
| neoplastic transformation |
22.7 |
3 |
15706412 (1), 10874008 (1), 12506033 (1) |
Human Genome Epidemiology (HuGE) Navigator: ATF1 (23 documents)
Export disorders for ATF1 gene to outside databases
|
Publications
for ATF1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ATF1 gene, integrated from 9 sources (see all 260):
(articles sorted by number of sources associating them with ATF1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A. (PubMed id 1655749)1, 2, 9 Rehfuss R.P.... Goodman R.H. (1991)
- EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts. (PubMed id 8401579)1, 3, 9 Zucman J....Thomas G. (1993)
- Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain. (PubMed id 2196176)1, 2, 9 Yoshimura T....Yoshida M. (1990)
- Fusion of the EWSR1 and ATF1 genes without expression of the MITF-M transcript in angiomatoid fibrous histiocytoma. (PubMed id 15884099)1, 2, 9 Hallor K.H.... Panagopoulos I. (2005)
- Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation. (PubMed id 18794154)1, 2 Zheng D....Dong Z. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Regulation of activating transcription factor-1 and the cAMP response element-binding protein by Ca2+/calmodulin-dependent protein kinases type I, II, and IV. (PubMed id 8621702)1, 2 Sun P.... Maurer R.A. (1996)
- Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers. (PubMed id 2516827)1, 2 Hai T.... Green M.R. (1989)
- Molecular genetic characterization of the EWS/ATF1 fusion gene in clear cell sarcoma of tendons and aponeuroses. (PubMed id 11992546)1, 9 Panagopoulos I....Mandahl N. (2002)
- PIAS3 interacts with ATF1 and regulates the human ferritin H gene through an antioxidant-responsive element. (PubMed id 17565989)1, 9 Iwasaki K....Tsuji Y. (2007)
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External Searches for ATF1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing ATF1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing ATF1 gene
(According to HUGE)
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Specialized Databases showing ATF1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for ATF1 gene:
Search GeneIP for patents involving ATF1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for ATF1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for ATF1 | | OriGene shRNA RFP for ATF1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ATF1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATF1 | | | OriGene Protein Over-expression Lysate for ATF1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ATF1 | | OriGene 3'-UTR Clone for ATF1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATF1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATF1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ATF1 | | OriGene Custom Protein Services for ATF1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ATF1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ATF1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATF1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ATF1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATF1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATF1 |
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| | | | Search Tocris compounds for ATF1 |
| |  |  |  |  | | | | | | Recombinant Protein for ATF1 |
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 | | | ATF1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATF1 |
|  |  |  | | | | ThermoFisher Antibodies for ATF1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATF1 |
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