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Aliases for ATF1 Gene

Aliases for ATF1 Gene

  • Activating Transcription Factor 1 2 3 4 5
  • CAMP-Dependent Transcription Factor ATF-1 3 4
  • Cyclic AMP-Dependent Transcription Factor ATF-1 3
  • Protein TREB36 4
  • FUS/ATF-1 3
  • EWS-ATF1 3
  • TREB36 3

External Ids for ATF1 Gene

Previous GeneCards Identifiers for ATF1 Gene

  • GC12P051390
  • GC12P051189
  • GC12P050874
  • GC12P049444
  • GC12P048190

Summaries for ATF1 Gene

Entrez Gene Summary for ATF1 Gene

  • This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. [provided by RefSeq, Aug 2010]

GeneCards Summary for ATF1 Gene

ATF1 (Activating Transcription Factor 1) is a Protein Coding gene. Diseases associated with ATF1 include Melanoma Of Soft Tissue and Clear Cell Sarcoma. Among its related pathways are Signaling mediated by p38-alpha and p38-beta and Activated TLR4 signalling. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is CREB1.

UniProtKB/Swiss-Prot for ATF1 Gene

  • This protein binds the cAMP response element (CRE) (consensus: 5-GTGACGT[AC][AG]-3), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.

Gene Wiki entry for ATF1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATF1 Gene

Genomics for ATF1 Gene

Regulatory Elements for ATF1 Gene

Enhancers for ATF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G051019 1.7 Ensembl ENCODE dbSUPER 35.5 +260.9 260855 11.1 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC SLC11A2 ATF1 ENSG00000257298 LIMA1 HNRNPA3P10 LETMD1 TFCP2 CSRNP2 ENSG00000272368 GC12M051017
GH12G050612 1.8 FANTOM5 Ensembl ENCODE dbSUPER 27.8 -145.9 -145909 10.4 PKNOX1 ATF1 ZNF133 SIN3A GLI4 FEZF1 ZNF121 FOS ZNF263 YY2 LIMA1 ATF1 ENSG00000257298 TFCP2 DIP2B LARP4 FAM186A GC12P050634
GH12G050762 1.4 ENCODE dbSUPER 32.9 +1.1 1087 5.6 HDGF PKNOX1 FOXA2 CREB3L1 ARNT AGO1 ARID4B SIN3A FEZF1 DMAP1 ATF1 HNRNPA3P10 SLC11A2 BCDIN3D RNU6-1273P RNU6-769P FAM186A LARP4 CERS5 DIP2B
GH12G050783 1.8 FANTOM5 Ensembl ENCODE dbSUPER 21.5 +23.5 23541 6.6 FOXA2 PKNOX1 ZNF133 SIN3A BRCA1 GLIS2 ZNF207 FOS ZNF263 JUNB ATF1 CERS5 TFCP2 CSRNP2 BCDIN3D RNU6-1273P SLC11A2 HNRNPA3P10 DIP2B LIMA1
GH12G050056 1.3 ENCODE dbSUPER 23.2 -706.2 -706240 1.1 ZNF493 ZNF133 ARID4B SIN3A GLI4 ZNF2 GLIS2 ZNF302 ZNF416 ZNF207 LIMA1 ATF1 ENSG00000257298 CERS5 LOC101927267 PRPF40B BCDIN3D LOC100422296 ENSG00000257964 C1QL4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ATF1 on UCSC Golden Path with GeneCards custom track

Promoters for ATF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000051816 490 2801 HDGF PKNOX1 MLX CREB3L1 ARNT AGO1 ARID4B SIN3A FEZF1 DMAP1

Transcription factor binding sites by QIAGEN in the ATF1 gene promoter:

Genomic Location for ATF1 Gene

Chromosome:
12
Start:
50,763,710 bp from pter
End:
50,821,167 bp from pter
Size:
57,458 bases
Orientation:
Plus strand

Genomic View for ATF1 Gene

Genes around ATF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATF1 Gene

Proteins for ATF1 Gene

  • Protein details for ATF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18846-ATF1_HUMAN
    Recommended name:
    Cyclic AMP-dependent transcription factor ATF-1
    Protein Accession:
    P18846
    Secondary Accessions:
    • B4DRF9
    • P25168
    • Q9H4A8

    Protein attributes for ATF1 Gene

    Size:
    271 amino acids
    Molecular mass:
    29233 Da
    Quaternary structure:
    • Binds DNA as a dimer. Interacts with HIPK2 and CDK3.
    SequenceCaution:
    • Sequence=CAC15058.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ATF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATF1 Gene

Post-translational modifications for ATF1 Gene

  • Phosphorylated at Ser-198 by HIPK2 in response to genotoxic stress. This phosphorylation promotes transcription repression of FTH1 and other antioxidant detoxification genes. The CDK3-mediated phosphorylation at Ser-63 promotes its transactivation and transcriptional activities. Phosphorylated at Ser-63 by RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli.
  • Ubiquitination at Lys260
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ATF1 Gene

Domains & Families for ATF1 Gene

Gene Families for ATF1 Gene

Suggested Antigen Peptide Sequences for ATF1 Gene

Graphical View of Domain Structure for InterPro Entry

P18846

UniProtKB/Swiss-Prot:

ATF1_HUMAN :
  • Belongs to the bZIP family. ATF subfamily.
Family:
  • Belongs to the bZIP family. ATF subfamily.
genes like me logo Genes that share domains with ATF1: view

Function for ATF1 Gene

Molecular function for ATF1 Gene

GENATLAS Biochemistry:
activating transcription factor,cAMP regulated,mediating the E1A responsiveness and heterodimerizing with members of the JUN/FOS family,ubiquitous,with main expression in hippocampus and dentate gyrus,involved in malignant melanoma of soft tissues with translocation t(12;22)(q13;q12) (see EWSR1)
UniProtKB/Swiss-Prot Function:
This protein binds the cAMP response element (CRE) (consensus: 5-GTGACGT[AC][AG]-3), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.

Gene Ontology (GO) - Molecular Function for ATF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 1655749
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IDA 1655749
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS,IEA 2196176
GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IEA --
genes like me logo Genes that share ontologies with ATF1: view
genes like me logo Genes that share phenotypes with ATF1: view

Animal Model Products

miRNA for ATF1 Gene

Targeted motifs for ATF1 Gene
HOMER Transcription Factor Regulatory Elements motif ATF1
  • Consensus sequence: GATGACGTCA Submotif: canonical Cell Type: K562 GEO ID: GSE31477

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ATF1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ATF1 Gene

Localization for ATF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATF1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATF1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ATF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 8798441
GO:0005654 nucleoplasm TAS,IDA --
GO:0005667 transcription factor complex IEA --
GO:1990590 ATF1-ATF4 transcription factor complex IDA 12871976
genes like me logo Genes that share ontologies with ATF1: view

Pathways & Interactions for ATF1 Gene

genes like me logo Genes that share pathways with ATF1: view

SIGNOR curated interactions for ATF1 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ATF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0010976 positive regulation of neuron projection development IEA --
GO:0014070 response to organic cyclic compound IEA --
genes like me logo Genes that share ontologies with ATF1: view

Drugs & Compounds for ATF1 Gene

(12) Drugs for ATF1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pseudoephedrine Approved Pharma Target 628
cyclic amp Experimental Pharma 0

(8) Additional Compounds for ATF1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ATF1: view

Transcripts for ATF1 Gene

Unigene Clusters for ATF1 Gene

Activating transcription factor 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ATF1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATF1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10
SP1: - - -
SP2: - -
SP3: - -
SP4: - - - - -
SP5: - -
SP6: - -

Relevant External Links for ATF1 Gene

GeneLoc Exon Structure for
ATF1
ECgene alternative splicing isoforms for
ATF1

Expression for ATF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ATF1 Gene

Protein differential expression in normal tissues from HIPED for ATF1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (68.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ATF1 Gene



Protein tissue co-expression partners for ATF1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ATF1 Gene:

ATF1

SOURCE GeneReport for Unigene cluster for ATF1 Gene:

Hs.648565

Evidence on tissue expression from TISSUES for ATF1 Gene

  • Bone marrow(4.2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with ATF1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATF1 Gene

Orthologs for ATF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ATF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATF1 34 35
  • 99.75 (n)
cow
(Bos Taurus)
Mammalia ATF1 34 35
  • 93.7 (n)
oppossum
(Monodelphis domestica)
Mammalia ATF1 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATF1 34 35
  • 90.99 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ATF1 35
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atf1 34
  • 86.82 (n)
mouse
(Mus musculus)
Mammalia Atf1 34 35
  • 86.74 (n)
Gm1862 16
chicken
(Gallus gallus)
Aves ATF1 34 35
  • 80.3 (n)
lizard
(Anolis carolinensis)
Reptilia ATF1 35
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atf1 34
  • 72.05 (n)
zebrafish
(Danio rerio)
Actinopterygii atf1 34 35
  • 66.82 (n)
fruit fly
(Drosophila melanogaster)
Insecta CrebB-17A 35
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea crh-1 35
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.714 35
  • 36 (a)
OneToMany
Species where no ortholog for ATF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATF1 Gene

ENSEMBL:
Gene Tree for ATF1 (if available)
TreeFam:
Gene Tree for ATF1 (if available)

Paralogs for ATF1 Gene

Paralogs for ATF1 Gene

Pseudogenes.org Pseudogenes for ATF1 Gene

genes like me logo Genes that share paralogs with ATF1: view

Variants for ATF1 Gene

Sequence variations from dbSNP and Humsavar for ATF1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000027016 -- 50,773,535(+) ACCTC(C/T)GCCTC intron-variant
rs1000058315 -- 50,773,119(+) GCTGC(A/G)TAGTA intron-variant
rs1000105244 -- 50,795,295(+) CTGGT(A/G)ACTCC intron-variant
rs1000136423 -- 50,794,944(+) TATTT(-/A)AAAAA intron-variant
rs1000141638 -- 50,779,458(+) GGGTA(C/T)GTATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATF1 Gene

Variant ID Type Subtype PubMed ID
esv3629489 CNV loss 21293372
nsv1069665 CNV deletion 25765185
nsv1127269 CNV deletion 24896259
nsv1138132 CNV deletion 24896259

Variation tolerance for ATF1 Gene

Residual Variation Intolerance Score: 55.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.06; 37.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATF1 Gene

Human Gene Mutation Database (HGMD)
ATF1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATF1 Gene

Disorders for ATF1 Gene

MalaCards: The human disease database

(11) MalaCards diseases for ATF1 Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
melanoma of soft tissue
  • clear cell sarcoma of the tendons and aponeuroses
clear cell sarcoma
  • adult soft part clear cell sarcoma
fibrous histiocytoma
  • benign fibrous histiocytoma
histiocytoma
  • cutaneous fibrous histiocytoma
sarcomatosis
  • sarcomatosis nos
- elite association - COSMIC cancer census association via MalaCards
Search ATF1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ATF1_HUMAN
  • Angiomatoid fibrous histiocytoma (AFH) [MIM:612160]: A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis. Note=The gene represented in this entry may be involved in disease pathogenesis. Chromosomal aberrations involving ATF1 are found in patients with angiomatoid fibrous histiocytoma. Translocation t(12;16)(q13;p11.2) with FUS generates a chimeric ATF1/FUS protein. Translocation t(12;22)(q13;q12) with EWSR1 generates a chimeric ATF1/EWSR1 protein.

Relevant External Links for ATF1

Genetic Association Database (GAD)
ATF1
Human Genome Epidemiology (HuGE) Navigator
ATF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATF1
genes like me logo Genes that share disorders with ATF1: view

No data available for Genatlas for ATF1 Gene

Publications for ATF1 Gene

  1. Fusion of the EWSR1 and ATF1 genes without expression of the MITF-M transcript in angiomatoid fibrous histiocytoma. (PMID: 15884099) Hallor K.H. … Panagopoulos I. (Genes Chromosomes Cancer 2005) 3 4 22 64
  2. EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts. (PMID: 8401579) Zucman J. … Thomas G. (Nat. Genet. 1993) 2 3 22 64
  3. The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A. (PMID: 1655749) Rehfuss R.P. … Goodman R.H. (J. Biol. Chem. 1991) 3 4 22 64
  4. Multiple cDNA clones encoding nuclear proteins that bind to the tax- dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain. (PMID: 2196176) Yoshimura T. … Yoshida M. (EMBO J. 1990) 3 4 22 64
  5. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PMID: 21658281) Aouizerat B.E. … Tseng Z.H. (BMC Cardiovasc Disord 2011) 3 46 64

Products for ATF1 Gene

Sources for ATF1 Gene

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