Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ATF1 Gene

protein-coding   GIFtS: 72
GCID: GC12P051189

Activating Transcription Factor 1

  See ATF1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Activating Transcription Factor 11 2 3     FUS/ATF-12
CAMP-Dependent Transcription Factor ATF-12 3     Cyclic AMP-Dependent Transcription Factor ATF-12
TREB362 5     Protein TREB363
EWS-ATF12     

External Ids:    HGNC: 7831   Entrez Gene: 4662   Ensembl: ENSG000001232687   OMIM: 1238035   UniProtKB: P188463   

Export aliases for ATF1 gene to outside databases

Previous GC identifers: GC12P051390 GC12P050874 GC12P049444 GC12P048190


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ATF1 Gene:
This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region
leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream
target genes, which are related to growth, survival, and other cellular activities. This protein is
phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein
kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and
cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional
activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome
22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell
sarcoma. This gene has a pseudogene on chromosome 6. (provided by RefSeq, Aug 2010)

GeneCards Summary for ATF1 Gene:
ATF1 (activating transcription factor 1) is a protein-coding gene. Diseases associated with ATF1 include fibrous histiocytoma, and clear cell sarcoma. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is CREB1.

UniProtKB/Swiss-Prot: ATF1_HUMAN, P18846
Function: This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence
present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates
PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant
detoxification genes. Triggers cell proliferation and transformation

Gene Wiki entry for ATF1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the ATF1 gene promoter:
         TBP   ATF-2   TFIID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATF1 promoter sequence
   Search Chromatin IP Primers for ATF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q13

ATF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATF1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P051189:  view genomic region     (about GC identifiers)

Start:
51,157,493 bp from pter      End:
51,214,943 bp from pter
Size:
57,451 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ATF1_HUMAN, P18846 (See protein sequence)
Recommended Name: Cyclic AMP-dependent transcription factor ATF-1  
Size: 271 amino acids; 29233 Da
Subunit: Binds DNA as a dimer. Interacts with HIPK2 and CDK3
Sequence caution: Sequence=CAC15058.1; Type=Erroneous initiation;
Secondary accessions: P25168 Q9H4A8

Explore the universe of human proteins at neXtProt for ATF1: NX_P18846

Explore proteomics data for ATF1 at MOPED

Post-translational modifications: 

  • Phosphorylated at Ser-198 by HIPK2 in response to genotoxic stress. This phosphorylation promotes transcription
    repression of FTH1 and other antioxidant detoxification genes. The CDK3-mediated phosphorylation at Ser-63
    promotes its transactivation and transcriptional activities. Phosphorylated at Ser-63 by RPS6KA4 and RPS6KA5 in
    response to mitogenic or stress stimuli1
  • Ubiquitination2 at Lys260
  • Modification sites at PhosphoSitePlus

  • See ATF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005162.1  
    ENSEMBL proteins: 
     ENSP00000448592   ENSP00000448421   ENSP00000262053   ENSP00000448987   ENSP00000448921  
     ENSP00000438403  
    Reactome Protein details: P18846

    ATF1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ATF1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ATF1
    GenScript Custom Purified and Recombinant Proteins Services for ATF1
    Novus Biologicals ATF1 Proteins
    Novus Biologicals ATF1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for ATF1
    Cloud-Clone Corp. Proteins for ATF1

     
    Search eBioscience for Proteins for ATF1 

     
    antibodies-online proteins for ATF1 (11 products) 

     
    antibodies-online peptides for ATF1

    ATF1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ATF1
    R&D Systems Antibodies for ATF1
    OriGene Antibodies for ATF1
    OriGene Custom Antibody Services for ATF1
    Novus Biologicals ATF1 Antibodies
    Abcam antibodies for ATF1
    Cloud-Clone Corp. Antibodies for ATF1
    ThermoFisher Antibodies for ATF1
    antibodies-online antibodies for ATF1 (100 products) 

    ATF1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ATF1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ATF1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ATF1
    Cloud-Clone Corp. CLIAs for ATF1
    Search eBioscience for ELISAs for ATF1 
    antibodies-online kits for ATF1 (25 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    bZIP: basic leucine zipper proteins

    3 InterPro protein domains:
     IPR004827 bZIP
     IPR003102 Coactivator_CBP_pKID
     IPR001630 Leuzip_CREB

    Graphical View of Domain Structure for InterPro Entry P18846

    ProtoNet protein and cluster: P18846

    2 Blocks protein domains:
    IPB001630 cAMP response element binding (CREB) protein signature
    IPB011616 bZIP transcription factor


    UniProtKB/Swiss-Prot: ATF1_HUMAN, P18846
    Similarity: Belongs to the bZIP family. ATF subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain
    Similarity: Contains 1 KID (kinase-inducible) domain


    Find genes that share domains with ATF1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATF1_HUMAN, P18846
    Function: This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence
    present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates
    PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant
    detoxification genes. Triggers cell proliferation and transformation

         Genatlas biochemistry entry for ATF1:
    activating transcription factor,cAMP regulated,mediating the E1A responsiveness and heterodimerizing with members
    of the JUN/FOS family,ubiquitous,with main expression in hippocampus and dentate gyrus,involved in malignant
    melanoma of soft tissues with translocation t(12;22)(q13;q12) (see EWSR1)

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity TAS2196176
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI10722738
    GO:0032403protein complex binding IEA--
         
    Find genes that share ontologies with ATF1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ATF1:
     Increased S DNA content 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Atf1):
     cellular  embryogenesis  immune system  mortality/aging  nervous system 
     normal 

    Find genes that share phenotypes with ATF1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ATF1

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  GATGACGTCA 

    miRNA
    Products:
        
    miRTarBase miRNAs that target ATF1:
    hsa-mir-23a-5p (MIRT038958), hsa-mir-215-5p (MIRT024634), hsa-mir-192-5p (MIRT026443)

    Block miRNA regulation of human, mouse, rat ATF1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ATF1 (see all 19):
    hsa-miR-30c hsa-miR-30d hsa-miR-410 hsa-miR-340 hsa-miR-192 hsa-miR-548m hsa-miR-9 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidATF1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ATF1
    Predesigned siRNA for gene silencing in human, mouse, rat ATF1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ATF1

    Clone
    Products:
         
    OriGene clones in human, mouse for ATF1 (see all 7)
    OriGene ORF clones in mouse, rat for ATF1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ATF1 (NM_005171)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATF1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ATF1
    Browse ESI BIO Cell Lines and PureStem Progenitors for ATF1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATF1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ATF1_HUMAN, P18846: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IEA--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with ATF1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ATF1 About   (see all 31)  
    See pathways by source

    SuperPathContained pathways About
    1Toll Like Receptor 7/8 (TLR7/8) Cascade
    Toll Like Receptor 9 (TLR9) Cascade0.93
    MyD88 dependent cascade initiated on endosome0.69
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation0.93
    MyD88-independent cascade0.69
    Toll Like Receptor 7/8 (TLR7/8) Cascade0.69
    Toll Like Receptor 3 (TLR3) Cascade0.69
    2MAPK targets/ Nuclear events mediated by MAP kinases
    Nuclear Events (kinase and transcription factor activation)0.88
    MAP kinase activation in TLR cascade0.61
    MAPK targets/ Nuclear events mediated by MAP kinases0.80
    CREB phosphorylation0.00
    3Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    4ERK Signaling
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    5ErbB4 Pathway
    LPS Stimulated MAPK Signaling0.47
    PI3K Signaling in B-Lymphocyte0.35
    PACAP Signaling0.37


    Find genes that share SuperPaths with ATF1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for ATF1
        TGF-beta Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ATF1 (see all 18)
        MAPK Signaling
    PKA Signaling
    BRCA1 Pathway
    PI3K Signaling in B-Lymphocyte
    PACAP Signaling

    4 GeneGo (Thomson Reuters) Pathways for ATF1
        DNA damage Role of Brca1 and Brca2 in DNA repair
    Beta-2 adrenergic-dependent CFTR expression
    Development EDNRB signaling
    Development Thrombopoietin-regulated cell processes

    Selected BioSystems Pathways for ATF1 (see all 9)
        Myometrial Relaxation and Contraction Pathways
    EGFR1 Signaling Pathway
    Serotonin Receptor 4/6/7 and NR3C Signaling
    Integrated Breast Cancer Pathway
    IL-3 Signaling Pathway

    1 Reactome Pathway for ATF1
        CREB phosphorylation


    2 Kegg Pathways  (Kegg details for ATF1):
        HTLV-I infection
    Transcriptional misregulation in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ATF1: 
              NFKB Signaling Pathway in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              Transcription Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ATF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for ATF1 (P188461, 2, 3 ENSP000002620534) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000224774P678703, ENSP000004156154I2D: score=1 STRING: ENSP00000415615
    CSNK2BP678703I2D: score=1 
    ENSG00000206406P678703I2D: score=1 
    ENSG00000224398P678703I2D: score=1 
    ENSG00000228875P678703I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006351transcription, DNA-templated ----
    GO:0006355regulation of transcription, DNA-templated ----

    Find genes that share ontologies with ATF1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ATF1

    1 HMDB Compound for ATF1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    Selected Novoseek inferred chemical compound relationships for ATF1 gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cyclic amp 68 32 7776975 (3), 9489722 (2), 10706690 (2), 7730336 (1) (see all 14)
    leucine 52.9 8 2196176 (1), 14713288 (1), 10525188 (1), 9685505 (1) (see all 7)
    forskolin 44.7 1 11526505 (1)
    sb 203580 38 1 11243876 (1)
    (+-)-pgf2-alpha 37.3 3 15913451 (2), 15710429 (1)
    oligonucleotide 32.1 2 7779811 (1), 8294429 (1)
    12-o-tetradecanoylphorbol 13-acetate 32 1 12489106 (1)
    okadaic acid 19.8 1 12489106 (1)
    adenylate 12.1 2 16306050 (1), 10697414 (1)
    glucose 4.22 1 12846747 (1)



    Find genes that share compounds with ATF1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ATF1 gene: 
    NM_005171.4  

    Unigene Cluster for ATF1:

    Activating transcription factor 1
    Hs.648565  [show with all ESTs]
    Unigene Representative Sequence: NM_005171
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000552510 ENST00000549612 ENST00000262053(uc001rww.4 uc010smu.2)
    ENST00000551831 ENST00000552487 ENST00000539132
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ATF1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ATF1 (see all 19):
    hsa-miR-30c hsa-miR-30d hsa-miR-410 hsa-miR-340 hsa-miR-192 hsa-miR-548m hsa-miR-9 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidATF1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ATF1
    Predesigned siRNA for gene silencing in human, mouse, rat ATF1
    Clone
    Products:
         
    OriGene clones in human, mouse for ATF1 (see all 7)
    OriGene ORF clones in mouse, rat for ATF1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ATF1 (NM_005171)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATF1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ATF1
    OriGene qSTAR qPCR primer pairs in human, mouse for ATF1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ATF1
      QuantiTect SYBR Green Assays in human, mouse, rat ATF1
      QuantiFast Probe-based Assays in human, mouse, rat ATF1

    Additional mRNA sequence: 

    AK313406.1 BC029619.1 

    9 DOTS entries:

    DT.110842  DT.100768094  DT.95154366  DT.97823676  DT.121165334  DT.100768095  DT.121165341  DT.91725266 
    DT.91755802 

    Selected AceView cDNA sequences (see all 118):

    BM766993 CA424161 BX102171 AI498334 NM_005171 CR622614 AA173511 AA286945 
    CR624071 AA416928 BQ015538 AU280122 CD103623 AI004969 AA173421 BG402683 
    AI915422 BX509520 BV179619 BE616960 BX392004 BU069921 AW849006 BM127599 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ATF1 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10
    SP1:                    -           -     -                                                   
    SP2:                                -     -                                                   
    SP3:                    -           -                                                         
    SP4:        -     -     -           -     -                                                   
    SP5:                    -                 -                                                   


    ECgene alternative splicing isoforms for ATF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ATF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGGAGTAT
    ATF1 Expression
    About this image


    ATF1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    ATF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ATF1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.648565
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ATF1: 
              NFKB Signaling Pathway in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              Transcription Factors in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ATF1
    OriGene qSTAR qPCR primer pairs in human, mouse for ATF1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ATF1
    QuantiTect SYBR Green Assays in human, mouse, rat ATF1
    QuantiFast Probe-based Assays in human, mouse, rat ATF1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for ATF1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atf11 , 5 activating transcription factor 11, 5 86.74(n)1
    91.82(a)1
      15 (56.22 cM)5
    119081  NM_007497.31  NP_031523.31 
     1002278195 
    chicken
    (Gallus gallus)
    Aves ATF11 activating transcription factor 1 80.3(n)
    87.36(a)
      426873  XM_004949718.1  XP_004949775.1 
    lizard
    (Anolis carolinensis)
    Reptilia ATF16
    activating transcription factor 1
    68(a)
    1 ↔ 1
    2(91108479-91132965)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL898881.22   -- 72.66(n)    AL898881.2 
    zebrafish
    (Danio rerio)
    Actinopterygii atf11 activating transcription factor 1 66.82(n)
    75(a)
      325609  NM_199723.1  NP_956017.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CrebB-17A6
    Cyclic-AMP response element binding protein B at 1...
    22(a)
    1 → many
    X(18260733-18271897)
    worm
    (Caenorhabditis elegans)
    Secernentea crh-16
    Protein CRH-1, isoform g
    21(a)
    1 → many
    III(11657738-11693837) WBGene00000793


    ENSEMBL Gene Tree for ATF1 (if available)
    TreeFam Gene Tree for ATF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ATF1 gene
    CREB12  CREM2  
    Selected SIMAP similar genes for ATF1 using alignment to 6 protein entries:     ATF1_HUMAN (see all proteins) (see all similar genes):
    EWSR1/ATF1 fusion    BEAN1    CREB1    IRF2    LOC101929849    AAR2
    HINFP    TMEM78    PACRG    PPP2R5C    SLC35E3    PFKFB3
    CDK10    NEK4    PTPLAD1    pp12301    ABI2    ADCK1

    Find genes that share paralogs with ATF1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ATF1
    PGOHUM00000243295


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ATF1 (see all 1144)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1931506311,2
    --50989603(+) CAACAA/TCTGCC 1 -- us2k10--------
    rs1388161431,2
    --50989740(+) GTCTCA/GAACTC 1 -- us2k10--------
    rs108760811,2
    C,A--50989747(+) ACTCCC/TGACCT 1 -- us2k1 tfbs30--------
    rs1152714871,2
    F--50989793(+) GGAATT/AACAGT 1 -- us2k11Minor allele frequency- A:0.09WA 118
    rs1857082481,2
    --50989825(+) CCTCCC/TCCGCT 1 -- us2k10--------
    rs1902321071,2
    --50989889(+) AACACC/TAAAGA 1 -- us2k10--------
    rs1913551701,2
    --50989922(+) CTTCCA/GGCCAT 1 -- us2k10--------
    rs1835329171,2
    --50990036(+) TTTCAC/GTAATG 1 -- us2k10--------
    rs1160089561,2
    F--50990069(+) GTTGTC/ACCCTG 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1463306651,2
    --50990142(+) CTCTTA/GAGACT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ATF1 (51157493 - 51214943 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ATF1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv899078CNV Loss21882294
    nsv899077CNV Loss21882294

    Human Gene Mutation Database (HGMD): ATF1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ATF1
    DNA2.0 Custom Variant and Variant Library Synthesis for ATF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 123803    OMIM disorders: --

    UniProtKB/Swiss-Prot: ATF1_HUMAN, P18846
  • Angiomatoid fibrous histiocytoma (AFH) [MIM:612160]: A distinct variant of malignant fibrous histiocytoma
    that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic
    microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of
    hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a
    lymph node metastasis. Note=The gene represented in this entry may be involved in disease pathogenesis.
    Chromosomal aberrations involving ATF1 are found in patients with angiomatoid fibrous histiocytoma. Translocation
    t(12;16)(q13;p11.2) with FUS generates a chimeric ATF1/FUS protein. Translocation t(12;22)(q13;q12) with EWSR1
    generates a chimeric ATF1/EWSR1 protein

  • 7 diseases for ATF1:    
    About MalaCards
    fibrous histiocytoma    clear cell sarcoma    melanoma of soft parts    vulvar melanoma
    histiocytoma    peripheral primitive neuroectodermal tumor    liposarcoma

    4 diseases from the University of Copenhagen DISEASES database for ATF1:
    Sarcoma     Vulvar melanoma     Peripheral primitive neuroectodermal tumor     Myxoid liposarcoma

    Find genes that share disorders with ATF1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ATF1 gene (see all 21)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sarcoma clear cell 89.5 14 17000668 (1), 7493135 (1), 20362353 (1), 16285301 (1) (see all 11)
    histiocytoma fibrous 66.7 4 11063792 (1), 18300800 (1), 12915480 (1), 15884099 (1)
    ewings sarcoma 62 13 15150091 (1), 7493135 (1), 10766345 (1), 12021921 (1) (see all 9)
    liposarcoma myxoid 50.7 3 7493135 (1), 11063792 (1), 12915480 (1)
    carcinoma embryonal 48.2 2 7687341 (1), 7843287 (1)
    melanoma 48 13 16306050 (1), 7829090 (1), 10766345 (1), 16285301 (1) (see all 11)
    metastatic melanoma 43.6 4 16306050 (1), 19308689 (1), 10851072 (1)
    sarcoma 41.5 5 12721254 (1), 9160316 (1), 17724745 (1)
    tumors 29 12 17409099 (2), 16306050 (1), 7829090 (1), 7493135 (1) (see all 11)
    neoplastic transformation 22.7 3 15706412 (1), 10874008 (1), 12506033 (1)

    Genetic Association Database (GAD): ATF1
    Human Genome Epidemiology (HuGE) Navigator: ATF1 (23 documents)

    Export disorders for ATF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ATF1 gene, integrated from 10 sources (see all 262):
    (articles sorted by number of sources associating them with ATF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A. (PubMed id 1655749)1, 2, 9 Rehfuss R.P.... Goodman R.H. (J. Biol. Chem. 1991)
    2. EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts. (PubMed id 8401579)1, 3, 9 Zucman J....Thomas G. (Nat. Genet. 1993)
    3. Multiple cDNA clones encoding nuclear proteins that bind to the tax- dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain. (PubMed id 2196176)1, 2, 9 Yoshimura T.... Yoshida M. (EMBO J. 1990)
    4. Fusion of the EWSR1 and ATF1 genes without expression of the MITF-M transcript in angiomatoid fibrous histiocytoma. (PubMed id 15884099)1, 2, 9 Hallor K.H.... Panagopoulos I. (Genes Chromosomes Cancer 2005)
    5. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PubMed id 21658281)1, 4 Aouizerat B.E....Tseng Z.H. (BMC Cardiovasc Disord 2011)
    6. Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women. (PubMed id 19950226)1, 4 Kontorovich T....Friedman E. (Int. J. Cancer 2010)
    7. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population. (PubMed id 19714462)1, 4 Loizidou M.A....Kyriacou K. (Breast Cancer Res. Treat. 2010)
    10. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1, 4 Vega A....Carracedo A. (Gynecol. Oncol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 466 HGNC: 783 AceView: ATF1 Ensembl:ENSG00000123268 euGenes: HUgn466
    ECgene: ATF1 Kegg: 466 H-InvDB: ATF1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ATF1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ATF1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ATF1 gene:
    Search GeneIP for patents involving ATF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of ATF1
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for ATF1 (ATF1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ATF1   OriGene RNAi products in human, mouse, rat for ATF1  
     OriGene qPCR primer pairs and template standards for ATF1   OriGene Protein Over-expression Lysate for ATF1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ATF1  
     OriGene qSTAR qPCR primer pairs in human, mouse for ATF1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ATF1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ATF1   OriGene Custom Protein Services for ATF1  

     
     
     Block miRNA regulation of human, mouse, rat ATF1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ATF1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATF1 Predesigned siRNA for gene silencing in human, mouse, rat ATF1
     QuantiFast Probe-based Assays in human, mouse, rat ATF1 QuantiTect SYBR Green Assays in human, mouse, rat ATF1
     PCR Arrays including human, mouse, rat ATF1 Search Chromatin IP Primers for ATF1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ATF1  GeneGlobe Interaction Network for ATF1
     Regulatory tfbs in ATF1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ATF1 GenScript cDNA clones with any tag delivered in your preferred vector for ATF1
     GenScript Custom Assay Services for ATF1 GenScript Custom overexpressing Cell Line Services for ATF1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ATF1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ATF1 antibodies
     ATF1 proteins
     ATF1 lysates
     Antibodies for ATF1
     See all of Abcam's Antibodies, Kits and Proteins for ATF1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for ATF1
     Proteins for ATF1
     Antibodies for ATF1
     ELISAs for ATF1
     CLIAs for ATF1



     Browse ESI BIO Cell Lines and PureStem Progenitors for ATF1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATF1
     SwitchGear 3'UTR luciferase reporter plasmids for ATF1
     SwitchGear Promoter luciferase reporter plasmids for ATF1
     ThermoFisher Antibodies for ATF1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATF1
     Browse compounds at ApexBio
     Search Addgene for plasmids for ATF1
      Search eBioscience for proteins for ATF1
      Search eBioscience for elisas for ATF1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for ATF1
     antibodies-online antibodies for ATF1 (100 products)
     antibodies-online kits for ATF1 (25 products)
     antibodies-online peptides for ATF1
     antibodies-online proteins for ATF1 (11 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ATF1 gene at Home site.
    Version: 3.12.252 27 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4