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ATE1 Gene

protein-coding   GIFtS: 55
GCID: GC10M123492

Arginyltransferase 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Arginyltransferase 11 2 3
Arginine-TRNA--Protein Transferase 12 3
R-Transferase 12 3
EC 2.3.2.83 8
Arginyl-TRNA--Protein Transferase 12
Arginyl-TRNA-Protein Transferase2

External Ids:    HGNC: 7821   Entrez Gene: 111012   Ensembl: ENSG000001076697   OMIM: 6071035   UniProtKB: O952603   

Export aliases for ATE1 gene to outside databases

Previous GC identifers: GC10M122522 GC10M122745 GC10M123633 GC10M123167 GC10M117133


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ATE1 Gene:
This gene encodes an arginyltransferase, an enzyme that is involved in posttranslational conjugation of arginine
to N-terminal aspartate or glutamate residues. Conjugation of arginine to the N-terminal aspartate or glutamate
targets proteins for ubiquitin-dependent degradation. Alternative splicing results in multiple transcript
variants. (provided by RefSeq, Dec 2013)

GeneCards Summary for ATE1 Gene:
ATE1 (arginyltransferase 1) is a protein-coding gene. Diseases associated with ATE1 include amelogenesis imperfecta, and breast cancer. GO annotations related to this gene include arginyltransferase activity.

UniProtKB/Swiss-Prot: ATE1_HUMAN, O95260
Function: Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a
protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not
arginylate cysteine residues (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ATE1 gene promoter:
         ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATE1 promoter sequence
   Search Chromatin IP Primers for ATE1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATE1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.13   Ensembl cytogenetic band:  10q26.13   HGNC cytogenetic band: 10q26

ATE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATE1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M123492:  view genomic region     (about GC identifiers)

Start:
123,499,939 bp from pter      End:
123,688,316 bp from pter
Size:
188,378 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ATE1_HUMAN, O95260 (See protein sequence)
Recommended Name: Arginyl-tRNA--protein transferase 1  
Size: 518 amino acids; 59090 Da
Subunit: Monomer (Potential)
Caution: It is uncertain whether Met-1 or Met-37 is the initiator
Secondary accessions: O95261 Q5SQQ3 Q8WW04
Alternative splicing: 2 isoforms:  O95260-1   O95260-2   

Explore the universe of human proteins at neXtProt for ATE1: NX_O95260

Explore proteomics data for ATE1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ATE1 (O95260) (see all 5)
     LLCPETY  GYGSFHQ  VGVIDILP  TCCPQYTIR 


    See ATE1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001001976.1  NP_001275663.1  NP_001275664.1  NP_001275665.1  NP_008972.2  

    ENSEMBL proteins: 
     ENSP00000358039   ENSP00000397787   ENSP00000405099   ENSP00000440881   ENSP00000224652  
     ENSP00000358036   ENSP00000444852   ENSP00000444514  

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    Novus Biologicals ATE1 Protein
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    Cloud-Clone Corp. Proteins for ATE1

    ATE1 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for ATE1

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    Cloud-Clone Corp. ELISAs for ATE1
    Cloud-Clone Corp. CLIAs for ATE1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR007471 Arg_tRNA_PTrfase_N
     IPR016181 Acyl_CoA_acyltransferase
     IPR007472 Arg-tRNA-P_Trfase_C
     IPR017137 Arg-tRNA-P_Trfase_1_euk

    Graphical View of Domain Structure for InterPro Entry O95260

    ProtoNet protein and cluster: O95260

    1 Blocks protein domain: IPB007471 Arginine-tRNA-protein transferase

    UniProtKB/Swiss-Prot: ATE1_HUMAN, O95260
    Similarity: Belongs to the R-transferase family


    ATE1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATE1_HUMAN, O95260
    Function: Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a
    protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not
    arginylate cysteine residues (By similarity)
    Catalytic activity: L-arginyl-tRNA(Arg) + [protein] = tRNA(Arg) + L-arginyl-[protein]

         Enzyme Number (IUBMB): EC 2.3.2.81 2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004057arginyltransferase activity TAS9858543
    GO:0005515protein binding IPI--
         
    ATE1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ATE1:
     Synthetic lethal with c-Myc af 

         Selected MGI mutant phenotypes (inferred from 4 alleles(MGI details for Ate1) (see all 18):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism 
     integument  mortality/aging  muscle  nervous system  pigmentation 

    ATE1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ate1tm1Akas for ATE1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ATE1
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ATE1

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    miRTarBase miRNAs that target ATE1:
    hsa-let-7b-5p (MIRT051987), hsa-mir-335-5p (MIRT018958), hsa-mir-130b-3p (MIRT020247)

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    GenScript: all cDNA clones in your preferred vector (see all 2): ATE1 (NM_007041)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATE1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATE1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATE1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ATE1_HUMAN, O95260: Isoform ATE1-1: Nucleus (By similarity). Cytoplasm (By similarity)
    ATE1_HUMAN, O95260: Isoform ATE1-2: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    cytoskeleton1
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA9858543
    GO:0005737cytoplasm IDA9858543

    ATE1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ATE1
    Interactions:

        Search GeneGlobe Interaction Network for ATE1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for ATE1 (O952601, 3 ENSP000002246524) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHMP243863, ENSP000003503864I2D: score=1 STRING: ENSP00000350386
    RAE1P784063, ENSP000003602864I2D: score=1 STRING: ENSP00000360286
    TOP2BQ028803, ENSP000003967044I2D: score=1 STRING: ENSP00000396704
    TOP3AQ134723, ENSP000003216364I2D: score=1 STRING: ENSP00000321636
    RPS6P627533, ENSP000003697574I2D: score=3 STRING: ENSP00000369757
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016598protein arginylation NAS9858543

    ATE1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ATE1

    1 Novoseek inferred chemical compound relationship for ATE1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arginine 30.2 2 9858543 (1), 2168415 (1)



    ATE1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ATE1 gene (5 alternative transcripts): 
    NM_001001976.2  NM_001288734.1  NM_001288735.1  NM_001288736.1  NM_007041.3  

    Unigene Cluster for ATE1:

    Arginyltransferase 1
    Hs.632080  [show with all ESTs]
    Unigene Representative Sequence: AK124669
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369043(uc001lfp.3 uc010qts.2 uc010qtt.2) ENST00000423243
    ENST00000485281 ENST00000481784 ENST00000455628 ENST00000540606 ENST00000224652(uc001lfq.3 uc010qtr.2)
    ENST00000369040 ENST00000543447 ENST00000535655(uc001lfr.3 uc009xzu.3)


    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ATE1
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    GenScript: all cDNA clones in your preferred vector (see all 2): ATE1 (NM_007041)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATE1
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    OriGene qPCR primer pairs and template standards for ATE1
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      QuantiTect SYBR Green Assays in human, mouse, rat ATE1
      QuantiFast Probe-based Assays in human, mouse, rat ATE1

    Additional mRNA sequence: 

    AF079098.1 AF079099.1 AK124669.1 AK292657.1 AK295642.1 AK296356.1 AK299101.1 AK303604.1 
    AK308926.1 AK313057.1 BC022026.1 

    11 DOTS entries:

    DT.431583  DT.100723678  DT.40130136  DT.100749761  DT.121225604  DT.95330587  DT.100749762  DT.121225601 
    DT.95240465  DT.121225552  DT.75114388 

    Selected AceView cDNA sequences (see all 147):

    AI417642 NM_001001976 AW025861 BI962986 BU607520 AA308819 N73626 T30215 
    AI750147 CD677896 AL545886 F10714 BE552440 Z45747 BI712469 NM_007041 
    AA856726 BQ772132 BU674138 BX491024 CA841006 AA831822 CB161622 AI091391 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ATE1 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18a · 18b · 18c ·
    SP1:                                                                    -                 -           -     -     -           -           -                     
    SP2:                                                                          -           -           -     -     -           -           -                     
    SP3:              -     -     -           -                 -     -           -           -           -     -     -           -           -                     
    SP4:              -     -     -                                                                                                                                 
    SP5:                                                                                                                                                            

    ExUns: 18d · 18e · 18f · 18g
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for ATE1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ATE1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTTACGGTG
    ATE1 Expression
    About this image

    ATE1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ATE1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632080
        Custom PCR Arrays for ATE1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATE1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ATE1 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ate11 , 5 arginyltransferase 11, 5 84.9(n)1
    82.03(a)1
      7 (73.19 cM)5
    119071  NM_001136054.21  NP_001129526.11 
     1303915265 
    chicken
    (Gallus gallus)
    Aves ATE11 arginyltransferase 1 72.64(n)
    71.22(a)
      423936  NM_001079733.2  NP_001073201.1 
    lizard
    (Anolis carolinensis)
    Reptilia ATE16
    arginyltransferase 1
    58(a)
    1 ↔ 1
    3(64392055-64488833)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ate11 arginyltransferase 1 63.79(n)
    62.08(a)
      100495601  XM_002939522.2  XP_002939568.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ate11 arginyltransferase 1 61.33(n)
    59.55(a)
      100037311  NM_001089468.1  NP_001082937.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ate11 , 3 protein arginylation arginyltransferase3
    Ate11
    33(a)3
    49.3(n)1
    43.07(a)1
      56F113
    372881  NM_001274172.11  NP_001261101.11 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_K07A1.91 CELE_K07A1.9 50.45(n)
    45.16(a)
      172800  NM_182029.3  NP_871829.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ATE1(YGL017W)4 Arginyl-tRNA-protein transferase, catalyzes post-translational more   --   7(459854-461365) 852867  NP_011498.1 
    rice
    (Oryza sativa)
    Liliopsida Os.188442 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 70.72(n)    AK071336.1 


    ENSEMBL Gene Tree for ATE1 (if available)
    TreeFam Gene Tree for ATE1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ATE1 (see all 3704)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs37637521,2
    C,F,H--117132879(-) GCCAGC/GCCCCT 2 -- ds5001 trp39Minor allele frequency- G:0.06NS EA WA NA 744
    rs1889537681,2
    --117133029(+) ACTATC/GAAAGT 2 -- ds50010--------
    rs70923081,2
    C,F,A,H--117133125(+) ATGAGA/GCTTAG 2 -- ds5001 ese312Minor allele frequency- G:0.02NS EA NA CSA WA 1372
    rs1482996631,2
    --117133236(+) TCCAAA/GCTGGG 2 -- ds50010--------
    rs10580581,2
    F--117133332(-) GGTATC/GCATTT 2 -- ds50013Minor allele frequency- G:0.00MN NA 188
    rs744187731,2
    C--117133339(+) TACCTA/GATGCT 2 -- ds50010--------
    rs760303741,2
    C--117133340(+) ACCTGA/GTGCTA 2 -- ds50010--------
    rs748836561,2
    C,F--117133428(+) GAACAC/TTGAGT 2 -- ut311Minor allele frequency- T:0.01NA 120
    rs1130777431,2
    C,F--117133467(+) GACATA/GTTTTC 2 -- ut313Minor allele frequency- G:0.05CSA WA 122
    rs1856390441,2
    --117133487(+) AAATGA/GACTTT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for ATE1 (123499939 - 123688316 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ATE1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2742051CNV Deletion23290073
    esv2675411CNV Deletion23128226
    esv2665421CNV Deletion23128226
    esv269838CNV Insertion20981092
    nsv896051CNV Loss21882294
    nsv896050CNV Loss21882294
    nsv896052CNV Loss21882294
    nsv896053CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 607103    OMIM disorders: --

    4 diseases for ATE1:    About MalaCards
    amelogenesis imperfecta    breast cancer    alzheimer's disease    malaria

    1 disease from the University of Copenhagen DISEASES database for ATE1:
    Amelogenesis imperfecta

    ATE1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): ATE1
    Human Genome Epidemiology (HuGE) Navigator: ATE1 (2 documents)

    Export disorders for ATE1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ATE1 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with ATE1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Alternative splicing results in differential expression, activity, and localization of the two forms of arginyl-tRNA-protein transferase, a component of the N-end rule pathway. (PubMed id 9858543)1, 2, 9 Kwon Y.T.... Varshavsky A. (Mol. Cell. Biol. 1999)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    4. Arginyltransferase, its specificity, putative substrates, bidirectional promoter, and splicing-derived isoforms. (PubMed id 16943202)1, 3 Hu R.G....Varshavsky A. (J. Biol. Chem. 2006)
    5. Identification of mammalian arginyltransferases that modify a specific subset of protein substrates. (PubMed id 16002466)1, 3 Rai R. and Kashina A. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    8. The C-terminal proteolytic fragment of the breast cancer susceptibility type 1 protein (BRCA1) is degraded by the N-end rule pathway. (PubMed id 22262859)1 Xu Z....Fahlman R.P. (J. Biol. Chem. 2012)
    9. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    10. Arginylation-dependent regulation of a proteolytic product of talin is essential for cell-cell adhesion. (PubMed id 22665520)1 Zhang F....Kashina A. (J. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 11101 HGNC: 782 AceView: ATE1 Ensembl:ENSG00000107669 euGenes: HUgn11101
    ECgene: ATE1 H-InvDB: ATE1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ATE1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ATE1 gene:
    Search GeneIP for patents involving ATE1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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