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Aliases for ATE1 Gene

Aliases for ATE1 Gene

  • Arginyltransferase 1 2 3 4
  • EC 2.3.2.8 4 63
  • Arginine-TRNA--Protein Transferase 1 4
  • R-Transferase 1 4

External Ids for ATE1 Gene

Previous GeneCards Identifiers for ATE1 Gene

  • GC10M122522
  • GC10M122745
  • GC10M123633
  • GC10M123167
  • GC10M123492
  • GC10M117133

Summaries for ATE1 Gene

Entrez Gene Summary for ATE1 Gene

  • This gene encodes an arginyltransferase, an enzyme that is involved in posttranslational conjugation of arginine to N-terminal aspartate or glutamate residues. Conjugation of arginine to the N-terminal aspartate or glutamate targets proteins for ubiquitin-dependent degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

GeneCards Summary for ATE1 Gene

ATE1 (Arginyltransferase 1) is a Protein Coding gene. GO annotations related to this gene include arginyltransferase activity.

UniProtKB/Swiss-Prot for ATE1 Gene

  • Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATE1 Gene

Genomics for ATE1 Gene

Regulatory Elements for ATE1 Gene

Transcription factor binding sites by QIAGEN in the ATE1 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ATE1 Gene

Start:
121,740,421 bp from pter
End:
121,928,801 bp from pter
Size:
188,381 bases
Orientation:
Minus strand

Genomic View for ATE1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATE1 Gene

Proteins for ATE1 Gene

  • Protein details for ATE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95260-ATE1_HUMAN
    Recommended name:
    Arginyl-tRNA--protein transferase 1
    Protein Accession:
    O95260
    Secondary Accessions:
    • O95261
    • Q5SQQ3
    • Q8WW04

    Protein attributes for ATE1 Gene

    Size:
    518 amino acids
    Molecular mass:
    59090 Da
    Quaternary structure:
    • Monomer. Interacts with LIAT1 (By similarity).

    Alternative splice isoforms for ATE1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATE1 Gene

Proteomics data for ATE1 Gene at MOPED

Selected DME Specific Peptides for ATE1 Gene

Post-translational modifications for ATE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for ATE1 Gene

Graphical View of Domain Structure for InterPro Entry

O95260

UniProtKB/Swiss-Prot:

ATE1_HUMAN :
  • O95260
Family:
  • Belongs to the R-transferase family.
genes like me logo Genes that share domains with ATE1: view

No data available for Gene Families for ATE1 Gene

Function for ATE1 Gene

Molecular function for ATE1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: L-arginyl-tRNA(Arg) + [protein] = tRNA(Arg) + L-arginyl-[protein]
UniProtKB/Swiss-Prot Function: Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity).

Enzyme Numbers (IUBMB) for ATE1 Gene

Gene Ontology (GO) - Molecular Function for ATE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004057 arginyltransferase activity TAS 9858543
GO:0005515 protein binding IPI 23455924
genes like me logo Genes that share ontologies with ATE1: view
genes like me logo Genes that share phenotypes with ATE1: view

Animal Models for ATE1 Gene

MGI Knock Outs for ATE1:

Animal Model Products

CRISPR Products

miRNA for ATE1 Gene

miRTarBase miRNAs that target ATE1

No data available for Transcription Factor Targeting and HOMER Transcription for ATE1 Gene

Localization for ATE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATE1 Gene

Isoform ATE1-1: Nucleus. Cytoplasm.
Isoform ATE1-2: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATE1 Gene COMPARTMENTS Subcellular localization image for ATE1 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ATE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 9858543
GO:0005737 cytoplasm IDA 9858543
genes like me logo Genes that share ontologies with ATE1: view

Pathways for ATE1 Gene

SuperPathways for ATE1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ATE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016598 protein arginylation NAS 9858543
genes like me logo Genes that share ontologies with ATE1: view

No data available for Pathways by source for ATE1 Gene

Compounds for ATE1 Gene

(1) Novoseek inferred chemical compound relationships for ATE1 Gene

Compound -log(P) Hits PubMed IDs
arginine 30.2 2
genes like me logo Genes that share compounds with ATE1: view

Transcripts for ATE1 Gene

Unigene Clusters for ATE1 Gene

Arginyltransferase 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATE1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATE1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18a · 18b · 18c ·
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - -
SP5:
SP6: - - - -
SP7: - - -
SP8: - -
SP9: - - - -
SP10: -

ExUns: 18d · 18e · 18f · 18g
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for ATE1 Gene

GeneLoc Exon Structure for
ATE1
ECgene alternative splicing isoforms for
ATE1

Expression for ATE1 Gene

mRNA expression in normal human tissues for ATE1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATE1 Gene

SOURCE GeneReport for Unigene cluster for ATE1 Gene Hs.632080

genes like me logo Genes that share expressions with ATE1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ATE1 Gene

Orthologs for ATE1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATE1 35
  • 99.29 (n)
  • 99.03 (a)
ATE1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATE1 35
  • 85.24 (n)
  • 83.37 (a)
ATE1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATE1 35
  • 89.94 (n)
  • 90.33 (a)
ATE1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ate1 35
  • 84.9 (n)
  • 82.03 (a)
Ate1 16
Ate1 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATE1 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 24 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ate1 35
  • 81.85 (n)
  • 79.8 (a)
chicken
(Gallus gallus)
Aves ATE1 35
  • 72.64 (n)
  • 71.22 (a)
ATE1 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATE1 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ate1 35
  • 63.79 (n)
  • 62.08 (a)
zebrafish
(Danio rerio)
Actinopterygii ate1 35
  • 61.33 (n)
  • 59.55 (a)
ate1 36
  • 63 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010373 35
  • 49.07 (n)
  • 44.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ate1 35
  • 49.3 (n)
  • 43.07 (a)
Ate1 36
  • 42 (a)
OneToOne
Ate1 37
  • 33 (a)
worm
(Caenorhabditis elegans)
Secernentea CELE_K07A1.9 35
  • 50.45 (n)
  • 45.16 (a)
K07A1.9 36
  • 37 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATE1 36
  • 22 (a)
OneToOne
ATE1 38
rice
(Oryza sativa)
Liliopsida Os.18844 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7900 36
  • 45 (a)
OneToOne
Species with no ortholog for ATE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATE1 Gene

ENSEMBL:
Gene Tree for ATE1 (if available)
TreeFam:
Gene Tree for ATE1 (if available)

Paralogs for ATE1 Gene

No data available for Paralogs for ATE1 Gene

Variants for ATE1 Gene

Sequence variations from dbSNP and Humsavar for ATE1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs719806 -- 121,807,231(-) AGTCA(G/T)GAAAT intron-variant
rs1058058 -- 121,743,088(-) GGTAT(C/G)CATTT utr-variant-3-prime, nc-transcript-variant
rs1128470 -- 121,828,097(-) TAAGA(A/C)ATTTC intron-variant
rs1128471 -- 121,828,066(-) CTTAC(A/G/T)AGGTA intron-variant
rs1219497 -- 121,743,417(+) TGAGC(A/G)TATCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ATE1 Gene

Variant ID Type Subtype PubMed ID
nsv896050 CNV Loss 21882294
esv269838 CNV Insertion 20981092
nsv896051 CNV Loss 21882294
esv2665421 CNV Deletion 23128226
nsv896052 CNV Loss 21882294
esv2675411 CNV Deletion 23128226
nsv896053 CNV Gain 21882294
esv2742051 CNV Deletion 23290073

Relevant External Links for ATE1 Gene

HapMap Linkage Disequilibrium report
ATE1
Human Gene Mutation Database (HGMD)
ATE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATE1 Gene

Disorders for ATE1 Gene

(1) University of Copenhagen DISEASES for ATE1 Gene

Relevant External Links for ATE1

Genetic Association Database (GAD)
ATE1
Human Genome Epidemiology (HuGE) Navigator
ATE1
genes like me logo Genes that share disorders with ATE1: view

No data available for UniProtKB/Swiss-Prot for ATE1 Gene

Publications for ATE1 Gene

  1. Alternative splicing results in differential expression, activity, and localization of the two forms of arginyl-tRNA-protein transferase, a component of the N-end rule pathway. (PMID: 9858543) Kwon Y.T. … Varshavsky A. (Mol. Cell. Biol. 1999) 3 4 23
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Identification of mammalian arginyltransferases that modify a specific subset of protein substrates. (PMID: 16002466) Rai R. … Kashina A. (Proc. Natl. Acad. Sci. U.S.A. 2005) 2 3
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48

Products for ATE1 Gene

Sources for ATE1 Gene

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