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Aliases for ATE1 Gene

Aliases for ATE1 Gene

  • Arginyltransferase 1 2 3 4 5
  • EC 2.3.2.8 4 63
  • Arginine-TRNA--Protein Transferase 1 4
  • R-Transferase 1 4

External Ids for ATE1 Gene

Previous GeneCards Identifiers for ATE1 Gene

  • GC10M122522
  • GC10M122745
  • GC10M123633
  • GC10M123167
  • GC10M123492
  • GC10M117133

Summaries for ATE1 Gene

Entrez Gene Summary for ATE1 Gene

  • This gene encodes an arginyltransferase, an enzyme that is involved in posttranslational conjugation of arginine to N-terminal aspartate or glutamate residues. Conjugation of arginine to the N-terminal aspartate or glutamate targets proteins for ubiquitin-dependent degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

GeneCards Summary for ATE1 Gene

ATE1 (Arginyltransferase 1) is a Protein Coding gene. Diseases associated with ATE1 include Distal 10Q Deletion Syndrome. GO annotations related to this gene include arginyltransferase activity.

UniProtKB/Swiss-Prot for ATE1 Gene

  • Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATE1 Gene

Genomics for ATE1 Gene

Regulatory Elements for ATE1 Gene

Enhancers for ATE1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ATE1 on UCSC Golden Path with GeneCards custom track

Promoters for ATE1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ATE1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ATE1 gene promoter:

Genomic Location for ATE1 Gene

Chromosome:
10
Start:
121,740,421 bp from pter
End:
121,928,801 bp from pter
Size:
188,381 bases
Orientation:
Minus strand

Genomic View for ATE1 Gene

Genes around ATE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATE1 Gene

Proteins for ATE1 Gene

  • Protein details for ATE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95260-ATE1_HUMAN
    Recommended name:
    Arginyl-tRNA--protein transferase 1
    Protein Accession:
    O95260
    Secondary Accessions:
    • O95261
    • Q5SQQ3
    • Q8WW04

    Protein attributes for ATE1 Gene

    Size:
    518 amino acids
    Molecular mass:
    59090 Da
    Quaternary structure:
    • Monomer. Interacts with LIAT1 (By similarity).

    Alternative splice isoforms for ATE1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATE1 Gene

Proteomics data for ATE1 Gene at MOPED

Selected DME Specific Peptides for ATE1 Gene

Post-translational modifications for ATE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for ATE1 Gene

Graphical View of Domain Structure for InterPro Entry

O95260

UniProtKB/Swiss-Prot:

ATE1_HUMAN :
  • Belongs to the R-transferase family.
Family:
  • Belongs to the R-transferase family.
genes like me logo Genes that share domains with ATE1: view

No data available for Gene Families for ATE1 Gene

Function for ATE1 Gene

Molecular function for ATE1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
L-arginyl-tRNA(Arg) + [protein] = tRNA(Arg) + L-arginyl-[protein].
UniProtKB/Swiss-Prot Function:
Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity).

Enzyme Numbers (IUBMB) for ATE1 Gene

Gene Ontology (GO) - Molecular Function for ATE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004057 arginyltransferase activity TAS 9858543
genes like me logo Genes that share ontologies with ATE1: view
genes like me logo Genes that share phenotypes with ATE1: view

Animal Models for ATE1 Gene

MGI Knock Outs for ATE1:

Animal Model Products

miRNA for ATE1 Gene

miRTarBase miRNAs that target ATE1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ATE1 Gene

Localization for ATE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATE1 Gene

Isoform ATE1-1: Nucleus. Cytoplasm.
Isoform ATE1-2: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATE1 Gene COMPARTMENTS Subcellular localization image for ATE1 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for ATE1 Gene

Pathways & Interactions for ATE1 Gene

SuperPathways for ATE1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ATE1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ATE1 Gene

Drugs & Compounds for ATE1 Gene

(1) Drugs for ATE1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ATE1: view

Transcripts for ATE1 Gene

Unigene Clusters for ATE1 Gene

Arginyltransferase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATE1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18a · 18b · 18c ·
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - -
SP5:
SP6: - - - -
SP7: - - -
SP8: - -
SP9: - - - -
SP10: -

ExUns: 18d · 18e · 18f · 18g
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for ATE1 Gene

GeneLoc Exon Structure for
ATE1
ECgene alternative splicing isoforms for
ATE1

Expression for ATE1 Gene

mRNA expression in normal human tissues for ATE1 Gene

Protein differential expression in normal tissues from HIPED for ATE1 Gene

This gene is overexpressed in Adrenal (17.0), Peripheral blood mononuclear cells (13.3), and Testis (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATE1 Gene



SOURCE GeneReport for Unigene cluster for ATE1 Gene Hs.632080

genes like me logo Genes that share expression patterns with ATE1: view

Protein tissue co-expression partners for ATE1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ATE1 Gene

Orthologs for ATE1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATE1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ATE1 35
  • 85.24 (n)
  • 83.37 (a)
ATE1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATE1 35
  • 89.94 (n)
  • 90.33 (a)
ATE1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ate1 35
  • 84.9 (n)
  • 82.03 (a)
Ate1 16
Ate1 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ATE1 35
  • 99.29 (n)
  • 99.03 (a)
ATE1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ate1 35
  • 81.85 (n)
  • 79.8 (a)
oppossum
(Monodelphis domestica)
Mammalia ATE1 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 24 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
chicken
(Gallus gallus)
Aves ATE1 35
  • 72.64 (n)
  • 71.22 (a)
ATE1 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATE1 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ate1 35
  • 63.79 (n)
  • 62.08 (a)
zebrafish
(Danio rerio)
Actinopterygii ate1 35
  • 61.33 (n)
  • 59.55 (a)
ate1 36
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ate1 37
  • 33 (a)
Ate1 35
  • 49.3 (n)
  • 43.07 (a)
Ate1 36
  • 42 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010373 35
  • 49.07 (n)
  • 44.54 (a)
worm
(Caenorhabditis elegans)
Secernentea CELE_K07A1.9 35
  • 50.45 (n)
  • 45.16 (a)
K07A1.9 36
  • 37 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATE1 36
  • 22 (a)
OneToOne
ATE1 38
rice
(Oryza sativa)
Liliopsida Os.18844 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7900 36
  • 45 (a)
OneToOne
Species with no ortholog for ATE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATE1 Gene

ENSEMBL:
Gene Tree for ATE1 (if available)
TreeFam:
Gene Tree for ATE1 (if available)

Paralogs for ATE1 Gene

No data available for Paralogs for ATE1 Gene

Variants for ATE1 Gene

Sequence variations from dbSNP and Humsavar for ATE1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1693674 -- 121,753,717(+) AAATA(C/T)TCATC intron-variant
rs1693675 -- 121,754,717(+) ACACC(A/G)TCTCA intron-variant
rs1693676 -- 121,755,698(+) cagag(A/T)gcttg intron-variant
rs1696834 -- 121,741,655(+) CTAAG(C/G)GAGCC nc-transcript-variant, utr-variant-3-prime
rs1696838 -- 121,750,540(-) TGGGG(A/G)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATE1 Gene

Variant ID Type Subtype PubMed ID
nsv896050 CNV Loss 21882294
esv269838 CNV Insertion 20981092
nsv896051 CNV Loss 21882294
esv2665421 CNV Deletion 23128226
nsv896052 CNV Loss 21882294
esv2675411 CNV Deletion 23128226
nsv896053 CNV Gain 21882294
esv2742051 CNV Deletion 23290073

Variation tolerance for ATE1 Gene

Residual Variation Intolerance Score: 47.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.38; 27.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATE1 Gene

Human Gene Mutation Database (HGMD)
ATE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATE1 Gene

Disorders for ATE1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ATE1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
distal 10q deletion syndrome
  • chromosome 10q26 deletion syndrome
- elite association - COSMIC cancer census association via MalaCards
Search ATE1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ATE1

Genetic Association Database (GAD)
ATE1
Human Genome Epidemiology (HuGE) Navigator
ATE1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATE1
genes like me logo Genes that share disorders with ATE1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ATE1 Gene

Publications for ATE1 Gene

  1. Alternative splicing results in differential expression, activity, and localization of the two forms of arginyl-tRNA-protein transferase, a component of the N-end rule pathway. (PMID: 9858543) Kwon Y.T. … Varshavsky A. (Mol. Cell. Biol. 1999) 3 4 23 67
  2. Arginyltransferase, its specificity, putative substrates, bidirectional promoter, and splicing-derived isoforms. (PMID: 16943202) Hu R.G. … Varshavsky A. (J. Biol. Chem. 2006) 2 3
  3. Identification of mammalian arginyltransferases that modify a specific subset of protein substrates. (PMID: 16002466) Rai R. … Kashina A. (Proc. Natl. Acad. Sci. U.S.A. 2005) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Inhibition of arginyltransferase 1 induces transcriptional activity of myocardin-related transcription factor A (MRTF-A) and promotes directional migration. (PMID: 25381249) Eisenach P.A. … Posern G. (J. Biol. Chem. 2014) 3

Products for ATE1 Gene

Sources for ATE1 Gene

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