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Aliases for ATE1 Gene

Aliases for ATE1 Gene

  • Arginyltransferase 1 2 3 4 5
  • EC 2.3.2.8 4 61
  • Arginine-TRNA--Protein Transferase 1 4
  • R-Transferase 1 4

External Ids for ATE1 Gene

Previous GeneCards Identifiers for ATE1 Gene

  • GC10M122522
  • GC10M122745
  • GC10M123633
  • GC10M123167
  • GC10M123492
  • GC10M117133

Summaries for ATE1 Gene

Entrez Gene Summary for ATE1 Gene

  • This gene encodes an arginyltransferase, an enzyme that is involved in posttranslational conjugation of arginine to N-terminal aspartate or glutamate residues. Conjugation of arginine to the N-terminal aspartate or glutamate targets proteins for ubiquitin-dependent degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

GeneCards Summary for ATE1 Gene

ATE1 (Arginyltransferase 1) is a Protein Coding gene. Diseases associated with ATE1 include Chromosome 10Q26 Deletion Syndrome. GO annotations related to this gene include arginyltransferase activity.

UniProtKB/Swiss-Prot for ATE1 Gene

  • Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATE1 Gene

Genomics for ATE1 Gene

Regulatory Elements for ATE1 Gene

Enhancers for ATE1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G121926 1.4 Ensembl ENCODE 12.7 0.0 -4 5.3 HDGF PKNOX1 FOXA2 ARNT WRNIP1 SIN3A DMAP1 ZNF2 YY1 ZNF766 ATE1-AS1 NSMCE4A ATE1 GC10P121933
GH10G121854 1 ENCODE 14.1 +73.8 73796 1.3 FOXA2 ATF1 MLX ARID4B SIN3A DMAP1 ZNF48 YY1 SLC30A9 ZNF143 ATE1-AS1 ATE1 ENSG00000201884 GC10P121871
GH10G121935 0.9 ENCODE 12.2 -7.2 -7236 1.6 HNRNPUL1 FOXA2 ARID4B DMAP1 ZNF48 YY1 ZNF121 PPARG KAT8 RCOR2 ATE1-AS1 ATE1 GC10P121933 GC10M121942
GH10G121942 0.9 Ensembl ENCODE 12.1 -14.3 -14276 1.3 JUN HLF CEBPB NR3C1 ZEB1 JUND ZNF692 GATA2 IKZF1 CEBPA NSMCE4A ATE1 ATE1-AS1 GC10M121943 GC10M121946
GH10G121910 0.7 ENCODE 14 +17.8 17803 1.5 MAFG BACH1 JUNB RELA ZNF316 MAFF NFE2L1 HNF4A NFE2 RELB ATE1 NSMCE4A ATE1-AS1 GC10M121896 GC10M121895 GC10M121913
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ATE1 on UCSC Golden Path with GeneCards custom track

Promoters for ATE1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000034486 1001 2401 HDGF ARNT WRNIP1 SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF207 ZNF143

Transcription factor binding sites by QIAGEN in the ATE1 gene promoter:

Genomic Location for ATE1 Gene

Chromosome:
10
Start:
121,740,421 bp from pter
End:
121,928,801 bp from pter
Size:
188,381 bases
Orientation:
Minus strand

Genomic View for ATE1 Gene

Genes around ATE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATE1 Gene

Proteins for ATE1 Gene

  • Protein details for ATE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95260-ATE1_HUMAN
    Recommended name:
    Arginyl-tRNA--protein transferase 1
    Protein Accession:
    O95260
    Secondary Accessions:
    • O95261
    • Q5SQQ3
    • Q8WW04

    Protein attributes for ATE1 Gene

    Size:
    518 amino acids
    Molecular mass:
    59090 Da
    Quaternary structure:
    • Monomer. Interacts with LIAT1 (By similarity).

    Alternative splice isoforms for ATE1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATE1 Gene

Selected DME Specific Peptides for ATE1 Gene

O95260:
  • LLCPETY
  • YDPDYSFLSLG
  • VGVIDILP
  • GYGSFHQ
  • TCCPQYTIR

Post-translational modifications for ATE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for ATE1 Gene

Graphical View of Domain Structure for InterPro Entry

O95260

UniProtKB/Swiss-Prot:

ATE1_HUMAN :
  • Belongs to the R-transferase family.
Family:
  • Belongs to the R-transferase family.
genes like me logo Genes that share domains with ATE1: view

No data available for Gene Families for ATE1 Gene

Function for ATE1 Gene

Molecular function for ATE1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
L-arginyl-tRNA(Arg) + [protein] = tRNA(Arg) + L-arginyl-[protein].
UniProtKB/Swiss-Prot Function:
Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity).

Enzyme Numbers (IUBMB) for ATE1 Gene

Gene Ontology (GO) - Molecular Function for ATE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004057 arginyltransferase activity TAS 9858543
GO:0005515 protein binding IPI 23455924
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
genes like me logo Genes that share ontologies with ATE1: view
genes like me logo Genes that share phenotypes with ATE1: view

Animal Models for ATE1 Gene

MGI Knock Outs for ATE1:

Animal Model Products

CRISPR Products

miRNA for ATE1 Gene

miRTarBase miRNAs that target ATE1

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ATE1 Gene

Localization for ATE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATE1 Gene

Isoform ATE1-1: Nucleus. Cytoplasm.
Isoform ATE1-2: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATE1 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ATE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 9858543
GO:0005737 cytoplasm IEA,IDA 9858543
genes like me logo Genes that share ontologies with ATE1: view

Pathways & Interactions for ATE1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ATE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016598 protein arginylation IEA,NAS 9858543
genes like me logo Genes that share ontologies with ATE1: view

No data available for Pathways by source and SIGNOR curated interactions for ATE1 Gene

Drugs & Compounds for ATE1 Gene

(1) Drugs for ATE1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ATE1: view

Transcripts for ATE1 Gene

Unigene Clusters for ATE1 Gene

Arginyltransferase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATE1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18a · 18b · 18c ·
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - -
SP5:
SP6: - - - -
SP7: - - -
SP8: - -
SP9: - - - -
SP10: -

ExUns: 18d · 18e · 18f · 18g
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for ATE1 Gene

GeneLoc Exon Structure for
ATE1
ECgene alternative splicing isoforms for
ATE1

Expression for ATE1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ATE1 Gene

Protein differential expression in normal tissues from HIPED for ATE1 Gene

This gene is overexpressed in Adrenal (17.0), Peripheral blood mononuclear cells (13.3), and Testis (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ATE1 Gene



Protein tissue co-expression partners for ATE1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ATE1 Gene:

ATE1

SOURCE GeneReport for Unigene cluster for ATE1 Gene:

Hs.632080

Evidence on tissue expression from TISSUES for ATE1 Gene

  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with ATE1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATE1 Gene

Orthologs for ATE1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATE1 34 35
  • 99.29 (n)
dog
(Canis familiaris)
Mammalia ATE1 34 35
  • 89.94 (n)
cow
(Bos Taurus)
Mammalia ATE1 34 35
  • 85.24 (n)
mouse
(Mus musculus)
Mammalia Ate1 34 16 35
  • 84.9 (n)
rat
(Rattus norvegicus)
Mammalia Ate1 34
  • 81.85 (n)
oppossum
(Monodelphis domestica)
Mammalia ATE1 35
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 70 (a)
OneToMany
-- 35
  • 58 (a)
OneToMany
-- 35
  • 24 (a)
OneToMany
chicken
(Gallus gallus)
Aves ATE1 34 35
  • 72.64 (n)
lizard
(Anolis carolinensis)
Reptilia ATE1 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ate1 34
  • 63.79 (n)
zebrafish
(Danio rerio)
Actinopterygii ate1 34 35
  • 61.33 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ate1 36 34 35
  • 49.3 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010373 34
  • 49.07 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_K07A1.9 34
  • 50.45 (n)
K07A1.9 35
  • 37 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATE1 35 37
  • 22 (a)
OneToOne
rice
(Oryza sativa)
Liliopsida Os.18844 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7900 35
  • 45 (a)
OneToOne
Species where no ortholog for ATE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATE1 Gene

ENSEMBL:
Gene Tree for ATE1 (if available)
TreeFam:
Gene Tree for ATE1 (if available)

Paralogs for ATE1 Gene

No data available for Paralogs for ATE1 Gene

Variants for ATE1 Gene

Sequence variations from dbSNP and Humsavar for ATE1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000027516 -- 121,835,377(+) TCTCC(C/T)CAGTC intron-variant
rs1000032107 -- 121,912,343(+) CCAAA(A/T)ATAAA intron-variant
rs1000039739 -- 121,783,384(+) AGTCA(C/T)CTAAA intron-variant
rs1000049246 -- 121,740,752(+) CATAA(C/T)AGATT nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1000086373 -- 121,762,369(+) TCAAT(C/G)ACCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATE1 Gene

Variant ID Type Subtype PubMed ID
esv2665421 CNV deletion 23128226
esv2675411 CNV deletion 23128226
esv3305561 CNV mobile element insertion 20981092
esv3354144 CNV insertion 20981092
esv3358854 CNV insertion 20981092
esv3624760 CNV loss 21293372
esv3624761 CNV loss 21293372
nsv475443 CNV novel sequence insertion 20440878

Variation tolerance for ATE1 Gene

Residual Variation Intolerance Score: 47.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.38; 27.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATE1 Gene

Human Gene Mutation Database (HGMD)
ATE1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATE1 Gene

Disorders for ATE1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ATE1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
chromosome 10q26 deletion syndrome
  • distal 10q deletion syndrome
- elite association - COSMIC cancer census association via MalaCards
Search ATE1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ATE1

Genetic Association Database (GAD)
ATE1
Human Genome Epidemiology (HuGE) Navigator
ATE1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATE1
genes like me logo Genes that share disorders with ATE1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ATE1 Gene

Publications for ATE1 Gene

  1. Alternative splicing results in differential expression, activity, and localization of the two forms of arginyl-tRNA-protein transferase, a component of the N-end rule pathway. (PMID: 9858543) Kwon Y.T. … Varshavsky A. (Mol. Cell. Biol. 1999) 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Arginyltransferase, its specificity, putative substrates, bidirectional promoter, and splicing-derived isoforms. (PMID: 16943202) Hu R.G. … Varshavsky A. (J. Biol. Chem. 2006) 2 3 64
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
  5. Identification of mammalian arginyltransferases that modify a specific subset of protein substrates. (PMID: 16002466) Rai R. … Kashina A. (Proc. Natl. Acad. Sci. U.S.A. 2005) 2 3 64

Products for ATE1 Gene

  • Addgene plasmids for ATE1

Sources for ATE1 Gene

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