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Aliases for ATAT1 Gene

Aliases for ATAT1 Gene

  • Alpha Tubulin Acetyltransferase 1 2 3
  • C6orf134 3 4 6
  • MEC17 3 4 6
  • Acetyltransferase Mec-17 Homolog 3 4
  • Alpha-TAT1 3 4
  • Alpha-TAT 3 4
  • TAT 3 4
  • Chromosome 6 Open Reading Frame 134 2
  • Alpha-Tubulin N-Acetyltransferase 1 3
  • Alpha-Tubulin N-Acetyltransferase 2
  • EC 2.3.1.108 4
  • Nbla00487 3

External Ids for ATAT1 Gene

Previous Symbols for ATAT1 Gene

  • C6orf134

Summaries for ATAT1 Gene

GeneCards Summary for ATAT1 Gene

ATAT1 (Alpha Tubulin Acetyltransferase 1) is a Protein Coding gene. Among its related pathways are Metabolism and Carbon metabolism. GO annotations related to this gene include tubulin N-acetyltransferase activity.

UniProtKB/Swiss-Prot for ATAT1 Gene

  • Specifically acetylates Lys-40 in alpha-tubulin on the lumenal side of microtubules. Required for normal sperm flagellar function. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATAT1 Gene

Genomics for ATAT1 Gene

Genomic Location for ATAT1 Gene

Start:
30,626,836 bp from pter
End:
30,646,823 bp from pter
Size:
19,988 bases
Orientation:
Plus strand

Genomic View for ATAT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATAT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

No data available for Regulatory Elements for ATAT1 Gene

Proteins for ATAT1 Gene

  • Protein details for ATAT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SQI0-ATAT_HUMAN
    Recommended name:
    Alpha-tubulin N-acetyltransferase 1
    Protein Accession:
    Q5SQI0
    Secondary Accessions:
    • A2AB28
    • Q3LIB0
    • Q5JP39
    • Q5JP40
    • Q5JP42
    • Q5SQI1
    • Q5SU03
    • Q86X42
    • Q8NDK9
    • Q9BRS1
    • Q9H8X5

    Protein attributes for ATAT1 Gene

    Size:
    421 amino acids
    Molecular mass:
    46810 Da
    Quaternary structure:
    • Component of the BBSome complex. Interacts with AP2 alpha-adaptins, including AP2A2, but not with AP1 gamma-adaptin (AP1G1/AP1G2); this interaction is required for efficient alpha-tubulin acetylation, hence clathrin-coated pits are sites of microtubule acetylation.

    Three dimensional structures from OCA and Proteopedia for ATAT1 Gene

    Alternative splice isoforms for ATAT1 Gene

neXtProt entry for ATAT1 Gene

Proteomics data for ATAT1 Gene at MOPED

Post-translational modifications for ATAT1 Gene

  • Autoacetylation strongly increases tubulin acetylation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ATAT1 Gene

Domains for ATAT1 Gene

Protein Domains for ATAT1 Gene

UniProtKB/Swiss-Prot:

ATAT_HUMAN
Domain:
  • Contains 1 N-acetyltransferase domain.:
    • Q5SQI0
Family:
  • Belongs to the acetyltransferase ATAT1 family.:
    • Q5SQI0
genes like me logo Genes that share domains with ATAT1: view

No data available for Gene Families for ATAT1 Gene

Function for ATAT1 Gene

Molecular function for ATAT1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=2.0 uM for free alpha-tubulin {ECO:0000269 PubMed:21068373, ECO:0000269 PubMed:23071314}; KM=1.6 uM for polymerized tubulin (microtubules) {ECO:0000269 PubMed:21068373, ECO:0000269 PubMed:23071314}; KM=2.2 uM for acetyl-CoA {ECO:0000269 PubMed:21068373, ECO:0000269 PubMed:23071314}; Note=kcat is 2.2 h(-1) for the acetylation of polymerized tubulin (microtubules), 0.35 h(-1) for the acetylation of free tubulin, and 1.47 h(-1)with acetyl-CoA as substrate.;
UniProtKB/Swiss-Prot CatalyticActivity: Acetyl-CoA + [alpha-tubulin]-L-lysine = CoA + [alpha-tubulin]-N(6)-acetyl-L-lysine.
UniProtKB/Swiss-Prot Function: Specifically acetylates Lys-40 in alpha-tubulin on the lumenal side of microtubules. Required for normal sperm flagellar function. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly.

Enzyme Numbers (IUBMB) for ATAT1 Gene

Gene Ontology (GO) - Molecular Function for ATAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019799 tubulin N-acetyltransferase activity IMP 20829795
GO:0050662 coenzyme binding IDA 23071314
genes like me logo Genes that share ontologies with ATAT1: view
genes like me logo Genes that share phenotypes with ATAT1: view

Animal Models for ATAT1 Gene

MGI Knock Outs for ATAT1:

miRNA for ATAT1 Gene

miRTarBase miRNAs that target ATAT1

No data available for Transcription Factor Targeting and HOMER Transcription for ATAT1 Gene

Localization for ATAT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATAT1 Gene

Cytoplasm. Membrane, clathrin-coated pit. Cell junction, focal adhesion. Cell projection, axon. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle.

Gene Ontology (GO) - Cellular Components for ATAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0005905 coated pit IEA --
GO:0005925 focal adhesion IEA --
GO:0030054 cell junction --
genes like me logo Genes that share ontologies with ATAT1: view

Pathways for ATAT1 Gene

genes like me logo Genes that share pathways with ATAT1: view

Interacting Proteins for ATAT1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000327832%0d%0a9606.ENSP00000377262%0d%0a
Selected Interacting proteins: ENSP00000327832 Q5SQI0-ATAT_HUMAN for ATAT1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for ATAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0007283 spermatogenesis IEA --
GO:0021542 dentate gyrus development IEA --
GO:0045598 regulation of fat cell differentiation IEA --
GO:0048666 neuron development IEA --
genes like me logo Genes that share ontologies with ATAT1: view

Transcripts for ATAT1 Gene

Unigene Clusters for ATAT1 Gene

Alpha tubulin acetyltransferase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATAT1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: -
SP2: - -
SP3: - - -
SP4:

Relevant External Links for ATAT1 Gene

GeneLoc Exon Structure for
ATAT1
ECgene alternative splicing isoforms for
ATAT1

Expression for ATAT1 Gene

mRNA expression in normal human tissues for ATAT1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ATAT1 Gene

SOURCE GeneReport for Unigene cluster for ATAT1 Gene Hs.654798

genes like me logo Genes that share expressions with ATAT1: view

Orthologs for ATAT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ATAT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATAT1 36
  • 97.47 (n)
  • 96.96 (a)
ATAT1 37
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATAT1 36
  • 89.03 (n)
  • 89.37 (a)
ATAT1 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATAT1 36
  • 88.97 (n)
  • 88.72 (a)
ATAT1 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atat1 36
  • 84.98 (n)
  • 87.09 (a)
Atat1 16
Atat1 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATAT1 37
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATAT1 37
  • 48 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atat1 36
  • 84.98 (n)
  • 87.85 (a)
lizard
(Anolis carolinensis)
Reptilia ATAT1 37
  • 62 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.11468 36
tropical clawed frog
(Silurana tropicalis)
Amphibia atat1 36
  • 60.44 (n)
  • 57.98 (a)
zebrafish
(Danio rerio)
Actinopterygii atat1 36
  • 58.33 (n)
  • 58.33 (a)
atat1 37
  • 41 (a)
OneToOne
wufj19c03 36
fruit fly
(Drosophila melanogaster)
Insecta CG17003 37
  • 33 (a)
OneToMany
CG3967 37
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea atat-2 37
  • 25 (a)
OneToMany
mec-17 37
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 41 (a)
OneToOne
Species with no ortholog for ATAT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATAT1 Gene

ENSEMBL:
Gene Tree for ATAT1 (if available)
TreeFam:
Gene Tree for ATAT1 (if available)

Paralogs for ATAT1 Gene

Selected SIMAP similar genes for ATAT1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ATAT1: view

No data available for Paralogs for ATAT1 Gene

Variants for ATAT1 Gene

Sequence variations from dbSNP and Humsavar for ATAT1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1079687 -- 30,640,496(-) AGGGG(C/T)CGGCA intron-variant
rs1140809 -- 30,643,899(+) TTAGA(A/C)CACCA intron-variant, utr-variant-3-prime
rs2006098 -- 30,639,050(-) tgagc(C/T)gagat intron-variant
rs2027936 -- 30,642,722(-) AAAAA(A/C)GGAAG intron-variant, downstream-variant-500B
rs2032133 -- 30,643,838(-) CTAAC(C/T)AAGAA intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ATAT1 Gene

Variant ID Type Subtype PubMed ID
esv2731791 CNV Deletion 23290073
nsv884086 CNV Gain 21882294
esv2670269 CNV Deletion 23128226
nsv830626 CNV Loss 17160897
esv2677891 CNV Deletion 23128226
dgv6526n71 CNV Loss 21882294

Relevant External Links for ATAT1 Gene

HapMap Linkage Disequilibrium report
ATAT1

Disorders for ATAT1 Gene

No disorders were found for ATAT1 Gene.

No data available for UniProtKB/Swiss-Prot for ATAT1 Gene

Publications for ATAT1 Gene

  1. MEC-17 is an alpha-tubulin acetyltransferase. (PMID: 20829795) Akella J.S. … Gaertig J. (Nature 2010) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Structure of the I+-tubulin acetyltransferase, I+TAT1, and implications for tubulin-specific acetylation. (PMID: 23071314) Friedmann D.R. … Marmorstein R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3 4
  4. Atomic resolution structure of human alpha-tubulin acetyltransferase bound to acetyl-CoA. (PMID: 23071318) Taschner M. … Lorentzen E. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3 4
  5. alphaTAT1 catalyses microtubule acetylation at clathrin-coated pits. (PMID: 24097348) Montagnac G. … Chavrier P. (Nature 2013) 3 4

Products for ATAT1 Gene

Sources for ATAT1 Gene

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