Aliases for ATAT1 Gene
External Ids for ATAT1 Gene
Previous HGNC Symbols for ATAT1 Gene
Previous GeneCards Identifiers for ATAT1 Gene
This gene encodes a protein that localizes to clathrin-coated pits, where it acetylates alpha tubulin on lysine 40. This process may be important in microtubule growth, for instance during chemotaxis and the formation of cilium. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
GeneCards Summary for ATAT1 Gene
ATAT1 (Alpha Tubulin Acetyltransferase 1) is a Protein Coding gene. Diseases associated with ATAT1 include Blood Coagulation Disease. Among its related pathways are Organelle biogenesis and maintenance. Gene Ontology (GO) annotations related to this gene include coenzyme binding and tubulin N-acetyltransferase activity.
UniProtKB/Swiss-Prot for ATAT1 Gene
Specifically acetylates Lys-40 in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly.