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Aliases for ATAD5 Gene

Aliases for ATAD5 Gene

  • ATPase Family, AAA Domain Containing 5 2 3
  • C17orf41 3 4 6
  • FRAG1 3 4 6
  • Chromosome Fragility-Associated Gene 1 Protein 3 4
  • Enhanced Level Of Genomic Instability 1 Homolog (S. Cerevisiae) 2
  • Enhanced Level Of Genomic Instability 1 Homolog 3
  • ATPase Family AAA Domain-Containing Protein 5 3
  • Chromosome Fragility Associated Gene 1 3
  • Chromosome 17 Open Reading Frame 41 2
  • FLJ12735 6
  • ELG1 3

External Ids for ATAD5 Gene

Previous HGNC Symbols for ATAD5 Gene

  • C17orf41

Previous GeneCards Identifiers for ATAD5 Gene

  • GC17P026185
  • GC17P029159
  • GC17P025369

Summaries for ATAD5 Gene

GeneCards Summary for ATAD5 Gene

ATAD5 (ATPase Family, AAA Domain Containing 5) is a Protein Coding gene. GO annotations related to this gene include nucleoside-triphosphatase activity.

UniProtKB/Swiss-Prot for ATAD5 Gene

  • Involved in DNA damage response. Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damages-induced apoptosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATAD5 Gene

Genomics for ATAD5 Gene

Regulatory Elements for ATAD5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ATAD5 Gene

Start:
30,831,970 bp from pter
End:
30,895,869 bp from pter
Size:
63,900 bases
Orientation:
Plus strand

Genomic View for ATAD5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATAD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATAD5 Gene

Proteins for ATAD5 Gene

  • Protein details for ATAD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QE3-ATAD5_HUMAN
    Recommended name:
    ATPase family AAA domain-containing protein 5
    Protein Accession:
    Q96QE3
    Secondary Accessions:
    • Q05DH0
    • Q69YR6
    • Q9H9I1

    Protein attributes for ATAD5 Gene

    Size:
    1844 amino acids
    Molecular mass:
    207570 Da
    Quaternary structure:
    • Interacts with RB1 predominantly in G1 phase via its LXCXE motif. Interacts with RAD9A in growing cells. The interaction with RAD9A is reduced after exposure to DNA replication-inhibiting agents. Interacts with BRD4.
    SequenceCaution:
    • Sequence=AAH15051.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAB14248.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ATAD5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATAD5 Gene

Proteomics data for ATAD5 Gene at MOPED

Post-translational modifications for ATAD5 Gene

Other Protein References for ATAD5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ATAD5 Gene

Domains for ATAD5 Gene

Gene Families for ATAD5 Gene

HGNC:
  • AATP :ATPases / AAA-type

Protein Domains for ATAD5 Gene

Suggested Antigen Peptide Sequences for ATAD5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96QE3

UniProtKB/Swiss-Prot:

ATAD5_HUMAN :
  • Q96QE3
Family:
  • Belongs to the AAA ATPase family.
genes like me logo Genes that share domains with ATAD5: view

Function for ATAD5 Gene

Molecular function for ATAD5 Gene

UniProtKB/Swiss-Prot Function: Involved in DNA damage response. Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damages-induced apoptosis.

Gene Ontology (GO) - Molecular Function for ATAD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ATAD5: view
genes like me logo Genes that share phenotypes with ATAD5: view

Animal Model Products

CRISPR Products

miRNA for ATAD5 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATAD5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ATAD5 Gene

Localization for ATAD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATAD5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATAD5 Gene COMPARTMENTS Subcellular localization image for ATAD5 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ATAD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ATAD5: view

Pathways for ATAD5 Gene

SuperPathways for ATAD5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ATAD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006974 cellular response to DNA damage stimulus IEA --
genes like me logo Genes that share ontologies with ATAD5: view

No data available for Pathways by source for ATAD5 Gene

Transcripts for ATAD5 Gene

Unigene Clusters for ATAD5 Gene

ATPase family, AAA domain containing 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATAD5

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ATAD5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATAD5 Gene

No ASD Table

Relevant External Links for ATAD5 Gene

GeneLoc Exon Structure for
ATAD5
ECgene alternative splicing isoforms for
ATAD5

Expression for ATAD5 Gene

mRNA expression in normal human tissues for ATAD5 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATAD5 Gene

SOURCE GeneReport for Unigene cluster for ATAD5 Gene Hs.528902

genes like me logo Genes that share expressions with ATAD5: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ATAD5 Gene

Orthologs for ATAD5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ATAD5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATAD5 35
  • 99.28 (n)
  • 98.54 (a)
ATAD5 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATAD5 35
  • 85.55 (n)
  • 78.88 (a)
ATAD5 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATAD5 35
  • 87.16 (n)
  • 80.87 (a)
ATAD5 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atad5 35
  • 79 (n)
  • 70.23 (a)
Atad5 16
Atad5 36
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATAD5 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 58 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
-- 36
  • 56 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Atad5 35
  • 79.23 (n)
  • 71.78 (a)
chicken
(Gallus gallus)
Aves ATAD5 35
  • 62.89 (n)
  • 52.63 (a)
ATAD5 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATAD5 36
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atad5 35
  • 54.21 (n)
  • 45.2 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
atad5a 35
  • 51.27 (n)
  • 41.39 (a)
atad5a 36
  • 34 (a)
OneToMany
atad5b 36
  • 29 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG16838 36
  • 21 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y53F4B.9 36
  • 17 (a)
OneToOne
Species with no ortholog for ATAD5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATAD5 Gene

ENSEMBL:
Gene Tree for ATAD5 (if available)
TreeFam:
Gene Tree for ATAD5 (if available)

Paralogs for ATAD5 Gene

No data available for Paralogs for ATAD5 Gene

Variants for ATAD5 Gene

Sequence variations from dbSNP and Humsavar for ATAD5 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs999796 -- 30,832,386(-) GGAGG(C/G)GGAGC synonymous-codon, reference
rs999797 -- 30,832,311(-) GACCT(C/T)ACGCG utr-variant-5-prime
rs999798 -- 30,831,822(-) TTGAA(C/T)TTCTG upstream-variant-2KB
rs1137934 -- 30,857,052(+) GGTAT(A/T)GCTCT synonymous-codon, reference
rs1139210 -- 30,887,320(-) ATCCA(G/T)AATTG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for ATAD5 Gene

Variant ID Type Subtype PubMed ID
esv2715813 CNV Deletion 23290073
nsv457720 CNV Loss 19166990
nsv908050 CNV Loss 21882294
dgv3140n71 CNV Loss 21882294
nsv908053 CNV Loss 21882294
nsv833412 CNV Loss 17160897
nsv908054 CNV Loss 21882294
esv2285349 CNV Deletion 18987734
esv2715815 CNV Deletion 23290073
dgv543e199 CNV Deletion 23128226
nsv908055 CNV Gain 21882294
esv2669402 CNV Deletion 23128226

Relevant External Links for ATAD5 Gene

HapMap Linkage Disequilibrium report
ATAD5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATAD5 Gene

Disorders for ATAD5 Gene

Relevant External Links for ATAD5

Genetic Association Database (GAD)
ATAD5
Human Genome Epidemiology (HuGE) Navigator
ATAD5
genes like me logo Genes that share disorders with ATAD5: view

No data available for UniProtKB/Swiss-Prot for ATAD5 Gene

Publications for ATAD5 Gene

  1. Molecular characterization and gene content of breakpoint boundaries in patients with neurofibromatosis type 1 with 17q11.2 microdeletions. (PMID: 11468690) Jenne D.E. … Kehrer-Sawatzki H. (Am. J. Hum. Genet. 2001) 2 3 4
  2. Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis. (PMID: 15983387) Ishii H. … Furukawa Y. (Proc. Natl. Acad. Sci. U.S.A. 2005) 2 3 4
  3. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson D.F. … Stefansson K. (Nat. Genet. 2008) 3 48
  4. RNF135 mutations are not present in patients with Sotos syndrome-like features. (PMID: 19291764) Visser R. … Losekoot M. (Am. J. Med. Genet. A 2009) 3 48
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for ATAD5 Gene

  • Addgene plasmids for ATAD5

Sources for ATAD5 Gene

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