ATAD5 Gene
protein-coding GIFtS: 45
GCID: GC17P029159
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ATPase family, AAA domain containing 5(Previous name: chromosome 17 open reading frame 41 )
(Previous symbol: C17orf41)
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Aliases
for ATAD5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| ATPase Family, AAA Domain Containing 51 2 | | FLJ127351 | | C17orf411 2 3 | | Chromosome 17 Open Reading Frame 411 | | FRAG11 2 3 | | ATPase Family AAA Domain-Containing Protein 52 | | ELG11 2 | | Chromosome Fragility Associated Gene 12 | | Chromosome Fragility-Associated Gene 1 Protein2 3 | | Enhanced Level Of Genomic Instability 1 Homolog2 |
Export aliases for ATAD5 gene to outside databasesPrevious GC identifers: GC17P026185 GC17P025369 |
Summaries
for ATAD5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ATAD5_HUMAN, Q96QE3Function: Involved in DNA damage response. Involved in a RAD9A-related damage checkpoint, a pathway that is importantin determining whether DNA damage is compatible with cell survival or whether it requires cell elimination byapoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damages-induced apoptosis
|
Genomic Views
for ATAD5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010799.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ATAD5 gene promoter:
AML1a ATF-2 GATA-1 FOXL1 C/EBPalpha Arnt POU2F1 POU2F1a c-Myb MRF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ATAD5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATAD5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q11.2 Ensembl cytogenetic band: 17q11.2 HGNC cytogenetic band: 17q11.2ATAD5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P029159: view genomic region
(about GC identifiers)
Start:
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29,158,988 bp from pter |
End:
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29,222,887 bp from pter |
Size:
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63,900 bases |
Orientation:
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plus strand |
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Proteins
for ATAD5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ATAD5_HUMAN, Q96QE3 (See
protein sequence)Recommended Name: ATPase family AAA domain-containing protein 5 Size: 1844 amino acids; 207570 Da
Subunit: Interacts with RB1 predominantly in G1 phase via its LXCXE motif. Interacts with RAD9A in growing cells. Theinteraction with RAD9A is reduced after exposure to DNA replication-inhibiting agents
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=AAH15051.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-Asequence; Sequence=BAB14248.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q05DH0 Q69YR6 Q9H9I1Alternative splicing: 2 isoforms: Q96QE3-1 Q96QE3-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ATAD5: NX_Q96QE3
Post-translational modifications:
ATR may stimulate the RAD9A dissociation1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96QE3
ATAD5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079133.3
ENSEMBL proteins: ENSP00000463102 ENSP00000313171
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ATAD5 for ontologies About GeneDecksing
ATAD5 Antibody Products:
Assay Products for ATAD5: |
Protein
Domains /
Families
for ATAD5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ATAD5 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96QE3ProtoNet protein and cluster: Q96QE3 UniProtKB/Swiss-Prot: ATAD5_HUMAN, Q96QE3Similarity: Belongs to the AAA ATPase family |
Function
for ATAD5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ATAD5_HUMAN, Q96QE3Function: Involved in DNA damage response. Involved in a RAD9A-related damage checkpoint, a pathway that is importantin determining whether DNA damage is compatible with cell survival or whether it requires cell elimination byapoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damages-induced apoptosis
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATAD5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: ATAD5 (NM_024857) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ATAD5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATAD5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATAD5 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005524 | ATP binding |
IEA | -- | | GO:0017111 | nucleoside-triphosphatase activity |
IEA | -- |
ATAD5 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for ATAD5:
Animal Models:
5 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Atad5):
ATAD5 for phenotypes About GeneDecksing
|
Pathways & Interactions
for ATAD5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ATAD5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 11)
5/11 Interacting proteins for ATAD5 (Q96QE33 ENSP000003131714) via UniProtKB, MINT, STRING, and/or I2D (see all 11)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006974 | response to DNA damage stimulus |
IEA | -- |
ATAD5 for ontologies About GeneDecksing
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Drugs & Compounds
for ATAD5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ATAD5
Search CenterWatch for drugs/clinical trials and news about ATAD5
|
Transcripts
for ATAD5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ATAD5 gene: NM_024857.3 Unigene Cluster for ATAD5: ATPase family, AAA domain containing 5 Hs.528902 [show with all ESTs]Unigene Representative Sequence: AY5576113 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000578295(uc002hft.1) ENST00000321990(uc002hfs.1) ENST00000585133
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATAD5 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATAD5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ATAD5 (NM_024857) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ATAD5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATAD5 |
Additional cDNA sequence: AJ314648.2 AK022797.1 AL832103.1 AY557611.1 BC015051.1 9 DOTS entries: DT.101284 DT.100744566 DT.314907 DT.206716 DT.97773111 DT.97800374 DT.75121201 DT.91889460 DT.95334559 24/47 AceView cDNA sequences (see all 47): BC015051 AL832103 BE042824 AA651909 CN483340 AA724028 AI623298 NM_024857 BE551573 AK022797 AA744478 AJ314648 CD643489 BU169441 AU126948 BG389184 BU509262 AA136031 BF669931 BE886708 BM312382 CB161634 BX435523 AA857981
GeneLoc Exon Structure
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Expression
for ATAD5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ATAD5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAAATTCTG
About this image
See ATAD5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ATAD5
SOURCE GeneReport for Unigene cluster: Hs.528902
SABiosciences Custom PCR Arrays for ATAD5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATAD5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ATAD5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATAD5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATAD5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATAD5 |
Orthologs
for ATAD5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ATAD5 gene from 8/21 species (see all 21) About this table
ENSEMBL Gene Tree for ATAD5 (if available)
TreeFam Gene Tree for ATAD5 (if available) |
Paralogs
for ATAD5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ATAD5 gene
- RFC12
ATAD5 for paralogs About GeneDecksing
|
Genomic Variants
for ATAD5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ATAD5 (29158988 - 29222887 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ATAD5
1 Indel: 45524 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ATAD5 |
|
Disorders
/ Diseases
for ATAD5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ATAD5 for disorders About GeneDecksing
OMIM gene information: 609534
OMIM disorders: --
4  diseases for ATAD5: About MalaCardssotos syndrome fanconi's anemia neurofibromatosis anemia
Human Genome Epidemiology (HuGE) Navigator: ATAD5 (3 documents)
Export disorders for ATAD5 gene to outside databases
|
Publications
for ATAD5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ATAD5 gene, integrated from 9 sources (see all 30):
(articles sorted by number of sources associating them with ATAD5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis. (PubMed id 15983387)1, 2, 3 Ishii H.... Furukawa Y. (2005)
- Molecular characterization and gene content of breakpoint boundaries in patients with neurofibromatosis type 1 with 17q11.2 microdeletions. (PubMed id 11468690)1, 2, 3 Jenne D.E....Kehrer-Sawatzki H. (2001)
- DNA damage responses by human ELG1 in S phase are imp ortant to maintain genomic integrity. (PubMed id 19755857)1, 3 Sikdar N....Myung K. (2009)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- Predisposition to cancer caused by genetic and functi onal defects of mammalian Atad5. (PubMed id 21901109)1 Bell D.W....Myung K. (2011)
- The Brd4 extraterminal domain confers transcription a ctivation independent of pTEFb by recruiting multiple proteins, including NSD3. (PubMed id 21555454)1 Rahman S....Howley P.M. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Dynamic regulation of PCNA ubiquitylation/deubiquityl ation. (PubMed id 21640107)1 Fox J.T....Myung K. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
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External Searches for ATAD5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ATAD5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ATAD5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ATAD5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ATAD5 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for ATAD5 gene:
Search GeneIP for patents involving ATAD5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ATAD5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ATAD5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ATAD5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATAD5 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ATAD5 | | OriGene 3'-UTR Clone for ATAD5 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATAD5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATAD5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ATAD5 | | OriGene Custom Protein Services for ATAD5 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ATAD5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ATAD5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATAD5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ATAD5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATAD5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATAD5 |
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 | | | ATAD5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATAD5 |
|  |  |  | | | | Search ThermoFisher Antibodies for ATAD5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATAD5 |
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