Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ATAD3C Gene

Aliases for ATAD3C Gene

  • ATPase Family, AAA Domain Containing 3C 2 3

External Ids for ATAD3C Gene

Previous GeneCards Identifiers for ATAD3C Gene

  • GC01P001471
  • GC01P001375
  • GC01P001376
  • GC01P000662
  • GC01P001385

Summaries for ATAD3C Gene

GeneCards Summary for ATAD3C Gene

ATAD3C (ATPase Family, AAA Domain Containing 3C) is a Protein Coding gene. GO annotations related to this gene include four-way junction helicase activity. An important paralog of this gene is ATAD3A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATAD3C Gene

Genomics for ATAD3C Gene

Regulatory Elements for ATAD3C Gene

Genomic Location for ATAD3C Gene

Chromosome:
1
Start:
1,441,301 bp from pter
End:
1,470,158 bp from pter
Size:
28,858 bases
Orientation:
Plus strand

Genomic View for ATAD3C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATAD3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATAD3C Gene

Proteins for ATAD3C Gene

  • Protein details for ATAD3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T2N8-ATD3C_HUMAN
    Recommended name:
    ATPase family AAA domain-containing protein 3C
    Protein Accession:
    Q5T2N8
    Secondary Accessions:
    • Q8N1Z5

    Protein attributes for ATAD3C Gene

    Size:
    411 amino acids
    Molecular mass:
    46380 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI01212.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=AAI01213.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=BAC04369.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=CAI22067.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI22656.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for ATAD3C Gene

Proteomics data for ATAD3C Gene at MOPED

Post-translational modifications for ATAD3C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATAD3C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ATAD3C Gene

Domains & Families for ATAD3C Gene

Protein Domains for ATAD3C Gene

Suggested Antigen Peptide Sequences for ATAD3C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T2N8

UniProtKB/Swiss-Prot:

ATD3C_HUMAN :
  • Belongs to the AAA ATPase family.
Family:
  • Belongs to the AAA ATPase family.
genes like me logo Genes that share domains with ATAD3C: view

Function for ATAD3C Gene

Gene Ontology (GO) - Molecular Function for ATAD3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ATAD3C: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATAD3C

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for ATAD3C Gene

Localization for ATAD3C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATAD3C Gene COMPARTMENTS Subcellular localization image for ATAD3C gene
Compartment Confidence
endoplasmic reticulum 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ATAD3C Gene

Pathways & Interactions for ATAD3C Gene

SuperPathways for ATAD3C Gene

No Data Available

Interacting Proteins for ATAD3C Gene

Gene Ontology (GO) - Biological Process for ATAD3C Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ATAD3C Gene

Drugs & Compounds for ATAD3C Gene

No Compound Related Data Available

Transcripts for ATAD3C Gene

Unigene Clusters for ATAD3C Gene

ATPase family, AAA domain containing 3C:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATAD3C

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATAD3C Gene

No ASD Table

Relevant External Links for ATAD3C Gene

GeneLoc Exon Structure for
ATAD3C
ECgene alternative splicing isoforms for
ATAD3C

Expression for ATAD3C Gene

mRNA expression in normal human tissues for ATAD3C Gene

Protein differential expression in normal tissues from HIPED for ATAD3C Gene

This gene is overexpressed in Saliva (43.0) and Brain (19.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ATAD3C Gene



SOURCE GeneReport for Unigene cluster for ATAD3C Gene Hs.724767

genes like me logo Genes that share expression patterns with ATAD3C: view

Protein tissue co-expression partners for ATAD3C Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ATAD3C Gene

Orthologs for ATAD3C Gene

This gene was present in the common ancestor of animals.

Orthologs for ATAD3C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATAD3C 35
  • 97.08 (n)
  • 95.38 (a)
ATAD3C 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATAD3 36
  • 58 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ATAD3A 36
  • 58 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 50 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Atad3a 36
  • 58 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 35 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 53 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 75 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii atad3b 36
  • 16 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta bor 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea atad-3 36
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6689 36
  • 45 (a)
OneToMany
Species with no ortholog for ATAD3C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ATAD3C Gene

ENSEMBL:
Gene Tree for ATAD3C (if available)
TreeFam:
Gene Tree for ATAD3C (if available)

Paralogs for ATAD3C Gene

Paralogs for ATAD3C Gene

(3) SIMAP similar genes for ATAD3C Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ATAD3C: view

Variants for ATAD3C Gene

Sequence variations from dbSNP and Humsavar for ATAD3C Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs904591 -- 1,444,615(-) ATGGA(C/T)GATGC intron-variant
rs1153092 -- 1,445,187(-) ATGGG(A/C)CCGTT utr-variant-5-prime, intron-variant
rs1153093 -- 1,445,234(-) TCTCC(C/G)ATGGG utr-variant-5-prime, intron-variant
rs1153094 -- 1,445,240(-) TCTCG(C/T)TCTCC utr-variant-5-prime, intron-variant
rs1240585 -- 1,446,075(-) ccacc(C/T)gccca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATAD3C Gene

Variant ID Type Subtype PubMed ID
nsv10161 CNV Gain+Loss 18304495
dgv10n71 CNV Loss 21882294
dgv12n71 CNV Loss 21882294
dgv19n71 CNV Loss 21882294
dgv20n71 CNV Loss 21882294
dgv30n71 CNV Gain 21882294
dgv31n71 CNV Gain 21882294
dgv32n71 CNV Gain+Loss 21882294
dgv33n71 CNV Loss 21882294
dgv34n71 CNV Loss 21882294
dgv38n71 CNV Loss 21882294
nsv871837 CNV Loss 21882294
nsv871690 CNV Gain 21882294
essv5472 CNV CNV 17122850
dgv9e1 CNV Complex 17122850
dgv40n71 CNV Loss 21882294
dgv41n71 CNV Gain 21882294
nsv482135 CNV Gain 20164927
esv2747363 CNV Deletion 23290073
esv2747474 CNV Deletion 23290073
dgv42n71 CNV Loss 21882294
dgv43n71 CNV Loss 21882294
esv2662001 CNV Deletion 23128226

Variation tolerance for ATAD3C Gene

Residual Variation Intolerance Score: 98.81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.24; 94.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATAD3C Gene

HapMap Linkage Disequilibrium report
ATAD3C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATAD3C Gene

Disorders for ATAD3C Gene

Relevant External Links for ATAD3C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATAD3C
genes like me logo Genes that share disorders with ATAD3C: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATAD3C Gene

Publications for ATAD3C Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PMID: 23455922) Varjosalo M. … Superti-Furga G. (Nat. Methods 2013) 67
  3. [ATAD3, a vital membrane-bound mitochondrial ATPase involved in tumor progression]. (PMID: 22192748) Li S. … Rousseau D. (Med Sci (Paris) 2011) 67
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 67
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67

Products for ATAD3C Gene

Sources for ATAD3C Gene

Back to Top

Content