Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ATAD3B Gene

Aliases for ATAD3B Gene

  • ATPase Family, AAA Domain Containing 3B 2 3 5
  • AAA-TOB3 3 4
  • TOB3 3 4
  • AAA-ATPase TOB3 3
  • KIAA1273 4

External Ids for ATAD3B Gene

Previous GeneCards Identifiers for ATAD3B Gene

  • GC01P001359
  • GC01P001493
  • GC01P001397
  • GC01P000680

Summaries for ATAD3B Gene

Entrez Gene Summary for ATAD3B Gene

  • The protein encoded by this gene is localized to the mitochondrial inner membrane, where it can bind to a highly-related protein, ATAD3A. ATAD3A appears to interact with matrix nucleoid complexes, and the encoded protein negatively regulates that interaction. This gene is expressed almost exclusively in pluripotent embryonic stem cells and some cancer cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

GeneCards Summary for ATAD3B Gene

ATAD3B (ATPase Family, AAA Domain Containing 3B) is a Protein Coding gene. An important paralog of this gene is ATAD3A.

UniProtKB/Swiss-Prot for ATAD3B Gene

  • May play a role in a mitochondrial network organization typical for stem cells, characterized by reduced mitochondrial metabolism, low mtDNA copies and fragmentated mitochondrial network. may act by suppressing ATAD3A function, interfering with ATAD3A interaction with matrix nucleoid complexes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATAD3B Gene

Genomics for ATAD3B Gene

Regulatory Elements for ATAD3B Gene

Enhancers for ATAD3B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ATAD3B on UCSC Golden Path with GeneCards custom track

Promoters for ATAD3B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ATAD3B on UCSC Golden Path with GeneCards custom track

Genomic Location for ATAD3B Gene

1,471,732 bp from pter
1,509,479 bp from pter
37,748 bases
Plus strand

Genomic View for ATAD3B Gene

Genes around ATAD3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATAD3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATAD3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATAD3B Gene

Proteins for ATAD3B Gene

  • Protein details for ATAD3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ATPase family AAA domain-containing protein 3B
    Protein Accession:
    Secondary Accessions:
    • A8K3H1
    • Q6ZRB5
    • Q9BUK4
    • Q9ULE7

    Protein attributes for ATAD3B Gene

    648 amino acids
    Molecular mass:
    72573 Da
    Quaternary structure:
    • Forms heterooligomers with ATAD3A. Interacts with components of the mitochondrial ribosome, including MRPL11 and MRPS18B, and with other proteins involved in mitochondrial RNA metabolism, possibly via interaction with ATAD3A. Interacts with GADD45GIP1.
    • Sequence=BAA86587.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ATAD3B Gene


neXtProt entry for ATAD3B Gene

Proteomics data for ATAD3B Gene at MOPED

Post-translational modifications for ATAD3B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATAD3B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ATAD3B Gene

Domains & Families for ATAD3B Gene

Gene Families for ATAD3B Gene

Protein Domains for ATAD3B Gene

Suggested Antigen Peptide Sequences for ATAD3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the AAA ATPase family.
  • Belongs to the AAA ATPase family.
genes like me logo Genes that share domains with ATAD3B: view

Function for ATAD3B Gene

Molecular function for ATAD3B Gene

UniProtKB/Swiss-Prot Function:
May play a role in a mitochondrial network organization typical for stem cells, characterized by reduced mitochondrial metabolism, low mtDNA copies and fragmentated mitochondrial network. may act by suppressing ATAD3A function, interfering with ATAD3A interaction with matrix nucleoid complexes.
UniProtKB/Swiss-Prot Induction:
Up-regulated by MYC.

Phenotypes for ATAD3B Gene

genes like me logo Genes that share phenotypes with ATAD3B: view

Animal Model Products

CRISPR Products

miRNA for ATAD3B Gene

miRTarBase miRNAs that target ATAD3B

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATAD3B Gene

Localization for ATAD3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATAD3B Gene

Mitochondrion inner membrane; Peripheral membrane protein. Note=Has been found to co-purify with nucleoids (PubMed:22453275). Since it does not face the mitochondrial matrix, the association with nucleoids could be mediated by ATAD3A. {ECO:0000269 PubMed:22453275}.

Subcellular locations from

Jensen Localization Image for ATAD3B Gene COMPARTMENTS Subcellular localization image for ATAD3B gene
Compartment Confidence
mitochondrion 4
cytosol 2
nucleus 2
extracellular 1
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for ATAD3B Gene

Pathways & Interactions for ATAD3B Gene

SuperPathways for ATAD3B Gene

No Data Available

Gene Ontology (GO) - Biological Process for ATAD3B Gene


No data available for Pathways by source and SIGNOR curated interactions for ATAD3B Gene

Drugs & Compounds for ATAD3B Gene

No Compound Related Data Available

Transcripts for ATAD3B Gene

Unigene Clusters for ATAD3B Gene

ATPase family, AAA domain containing 3B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATAD3B Gene

No ASD Table

Relevant External Links for ATAD3B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ATAD3B Gene

mRNA expression in normal human tissues for ATAD3B Gene

Protein differential expression in normal tissues from HIPED for ATAD3B Gene

This gene is overexpressed in Breast (17.4), Pancreas (11.7), Brain (11.5), Peripheral blood mononuclear cells (11.1), and Bone (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATAD3B Gene

SOURCE GeneReport for Unigene cluster for ATAD3B Gene Hs.729021

mRNA Expression by UniProt/SwissProt for ATAD3B Gene

Tissue specificity: Tends to be down-regulated in differentiated cells and re-expressed in pluripotent stem cells or cancer cells (at protein level).
genes like me logo Genes that share expression patterns with ATAD3B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for ATAD3B Gene

Orthologs for ATAD3B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATAD3B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ATAD3 36
  • 87 (a)
(Canis familiaris)
Mammalia ATAD3A 36
  • 87 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 79 (a)
(Mus musculus)
Mammalia Atad3a 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 86 (a)
(Pan troglodytes)
Mammalia ATAD3B 36
  • 95 (a)
(Gallus gallus)
Aves -- 36
  • 77 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 75 (a)
(Danio rerio)
Actinopterygii atad3b 36
  • 81 (a)
fruit fly
(Drosophila melanogaster)
Insecta bor 36
  • 58 (a)
(Caenorhabditis elegans)
Secernentea atad-3 36
  • 54 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G18330 35
  • 47.47 (n)
  • 40.12 (a)
(Oryza sativa)
Liliopsida Os02g0706500 35
  • 47.45 (n)
  • 38.88 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6689 36
  • 63 (a)
Species with no ortholog for ATAD3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ATAD3B Gene

Gene Tree for ATAD3B (if available)
Gene Tree for ATAD3B (if available)

Paralogs for ATAD3B Gene

Paralogs for ATAD3B Gene

(3) SIMAP similar genes for ATAD3B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ATAD3B: view

Variants for ATAD3B Gene

Sequence variations from dbSNP and Humsavar for ATAD3B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1240504 - 1,471,903(-) GTTAA(C/T)GCCGA nc-transcript-variant, reference, missense, utr-variant-5-prime
rs8241 -- 1,496,122(+) TCTGA(A/G)GCCGC intron-variant, nc-transcript-variant, utr-variant-3-prime
rs705580 -- 1,481,959(-) GGCCC(A/G)CACCA intron-variant
rs711179 -- 1,481,583(+) TTCAC(C/T)GTGGG intron-variant
rs819969 -- 1,482,123(-) AGAGG(C/T)AGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATAD3B Gene

Variant ID Type Subtype PubMed ID
nsv10161 CNV Gain+Loss 18304495
dgv10n71 CNV Loss 21882294
dgv19n71 CNV Loss 21882294
dgv20n71 CNV Loss 21882294
dgv31n71 CNV Gain 21882294
dgv33n71 CNV Loss 21882294
dgv34n71 CNV Loss 21882294
nsv871837 CNV Loss 21882294
nsv871690 CNV Gain 21882294
essv5472 CNV CNV 17122850
dgv9e1 CNV Complex 17122850
dgv41n71 CNV Gain 21882294
esv2747363 CNV Deletion 23290073
esv2747474 CNV Deletion 23290073
dgv42n71 CNV Loss 21882294
dgv43n71 CNV Loss 21882294
esv2662001 CNV Deletion 23128226
nsv482146 CNV Gain 20164927
esv1254392 CNV Insertion 17803354
esv2661503 CNV Deletion 23128226
esv25832 CNV Loss 19812545
nsv871421 CNV Loss 21882294
nsv871696 CNV Loss 21882294
dgv44n71 CNV Gain+Loss 21882294
nsv871954 CNV Loss 21882294
esv2747585 CNV Deletion 23290073
esv2747696 CNV Deletion 23290073

Variation tolerance for ATAD3B Gene

Residual Variation Intolerance Score: 99.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.40; 97.71% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ATAD3B Gene

Disorders for ATAD3B Gene

Relevant External Links for ATAD3B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ATAD3B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATAD3B Gene

Publications for ATAD3B Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Expression analysis of ATAD3 isoforms in rodent and human cell lines and tissues. (PMID: 24239551) Li S. … Rousseau D. (Gene 2014) 3

Products for ATAD3B Gene

Sources for ATAD3B Gene