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Aliases for ATAD3B Gene

Aliases for ATAD3B Gene

  • ATPase Family, AAA Domain Containing 3B 2 3
  • TOB3 3 4 6
  • AAA-TOB3 3 4
  • KIAA1273 4 6
  • ATPase Family AAA Domain-Containing Protein 3B 3
  • AAA-ATPase TOB3 3

External Ids for ATAD3B Gene

Summaries for ATAD3B Gene

Entrez Gene Summary for ATAD3B Gene

  • ATAD3A (MIM 612316) and ATAD3B are mitochondrial membrane proteins that contribute to the stabilization of large mitochondrial DNA (mtDNA)-protein complexes called nucleoids (He et al., 2007 [PubMed 17210950]).[supplied by OMIM, Sep 2008]

GeneCards Summary for ATAD3B Gene

ATAD3B (ATPase Family, AAA Domain Containing 3B) is a Protein Coding gene. GO annotations related to this gene include nucleoside-triphosphatase activity. An important paralog of this gene is ATAD3A.

UniProtKB/Swiss-Prot for ATAD3B Gene

  • May play a role in a mitochondrial network organization typical for stem cells, characterized by reduced mitochondrial metabolism, low mtDNA copies and fragmentated mitochondrial network. may act by suppressing ATAD3A function, interfering with ATAD3A interaction with matrix nucleoid complexes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATAD3B Gene

Genomics for ATAD3B Gene

Genomic Location for ATAD3B Gene

Start:
1,471,759 bp from pter
End:
1,509,472 bp from pter
Size:
37,714 bases
Orientation:
Plus strand

Genomic View for ATAD3B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATAD3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATAD3B Gene

Regulatory Elements for ATAD3B Gene

Proteins for ATAD3B Gene

  • Protein details for ATAD3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T9A4-ATD3B_HUMAN
    Recommended name:
    ATPase family AAA domain-containing protein 3B
    Protein Accession:
    Q5T9A4
    Secondary Accessions:
    • A8K3H1
    • Q6ZRB5
    • Q9BUK4
    • Q9ULE7

    Protein attributes for ATAD3B Gene

    Size:
    648 amino acids
    Molecular mass:
    72573 Da
    Quaternary structure:
    • Forms heterooligomers with ATAD3A. Interacts with components of the mitochondrial ribosome, including MRPL11 and MRPS18B, and with other proteins involved in mitochondrial RNA metabolism, possibly via interaction with ATAD3A. Interacts with GADD45GIP1.
    SequenceCaution:
    • Sequence=BAA86587.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ATAD3B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATAD3B Gene

Proteomics data for ATAD3B Gene at MOPED

Post-translational modifications for ATAD3B Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys394

Other Protein References for ATAD3B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ATAD3B Gene

Domains for ATAD3B Gene

Gene Families for ATAD3B Gene

HGNC:
  • AATP :ATPases / AAA-type

Protein Domains for ATAD3B Gene

UniProtKB/Swiss-Prot:

ATD3B_HUMAN
Family:
  • Belongs to the AAA ATPase family.:
    • Q5T9A4
genes like me logo Genes that share domains with ATAD3B: view

Function for ATAD3B Gene

Molecular function for ATAD3B Gene

UniProtKB/Swiss-Prot Function: May play a role in a mitochondrial network organization typical for stem cells, characterized by reduced mitochondrial metabolism, low mtDNA copies and fragmentated mitochondrial network. may act by suppressing ATAD3A function, interfering with ATAD3A interaction with matrix nucleoid complexes.
UniProtKB/Swiss-Prot Induction: Up-regulated by MYC.

Gene Ontology (GO) - Molecular Function for ATAD3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ATAD3B: view

miRNA for ATAD3B Gene

miRTarBase miRNAs that target ATAD3B

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ATAD3B Gene

Localization for ATAD3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATAD3B Gene

Mitochondrion inner membrane; Peripheral membrane protein. Note=Has been found to co-purify with nucleoids (PubMed:22453275). Since it does not face the mitochondrial matrix, the association with nucleoids could be mediated by ATAD3A. {ECO:0000269 PubMed:22453275}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATAD3B Gene COMPARTMENTS Subcellular localization image for ATAD3B gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 2
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ATAD3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IEA --
genes like me logo Genes that share ontologies with ATAD3B: view

Pathways for ATAD3B Gene

SuperPathways for ATAD3B Gene

No Data Available

Gene Ontology (GO) - Biological Process for ATAD3B Gene

None

No data available for Pathways by source for ATAD3B Gene

Transcripts for ATAD3B Gene

Unigene Clusters for ATAD3B Gene

ATPase family, AAA domain containing 3B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATAD3B Gene

No ASD Table

Relevant External Links for ATAD3B Gene

GeneLoc Exon Structure for
ATAD3B
ECgene alternative splicing isoforms for
ATAD3B

Expression for ATAD3B Gene

mRNA expression in normal human tissues for ATAD3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATAD3B Gene

SOURCE GeneReport for Unigene cluster for ATAD3B Gene Hs.729021

mRNA Expression by UniProt/SwissProt for ATAD3B Gene

Q5T9A4-ATD3B_HUMAN
Tissue specificity: Tends to be down-regulated in differentiated cells and re-expressed in pluripotent stem cells or cancer cells (at protein level).
genes like me logo Genes that share expressions with ATAD3B: view

Orthologs for ATAD3B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATAD3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATAD3B 37
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATAD3 37
  • 87 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ATAD3A 37
  • 87 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Atad3a 37
  • 87 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 79 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 86 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 37
  • 77 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 75 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii atad3b 37
  • 81 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta bor 37
  • 58 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea atad-3 37
  • 54 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G18330 36
  • 47.47 (n)
  • 40.12 (a)
rice
(Oryza sativa)
Liliopsida Os02g0706500 36
  • 47.45 (n)
  • 38.88 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6689 37
  • 63 (a)
OneToMany
Species with no ortholog for ATAD3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ATAD3B Gene

ENSEMBL:
Gene Tree for ATAD3B (if available)
TreeFam:
Gene Tree for ATAD3B (if available)

Paralogs for ATAD3B Gene

Paralogs for ATAD3B Gene

Selected SIMAP similar genes for ATAD3B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ATAD3B: view

Variants for ATAD3B Gene

Sequence variations from dbSNP and Humsavar for ATAD3B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs8241 -- 1,496,122(+) TCTGA(A/G)GCCGC utr-variant-3-prime, intron-variant, nc-transcript-variant
rs705580 -- 1,481,959(-) GGCCC(A/G)CACCA intron-variant
rs711179 -- 1,481,583(+) TTCAC(C/T)GTGGG intron-variant
rs819969 -- 1,482,123(-) AGAGG(C/T)AGGGC intron-variant
rs819970 -- 1,482,316(+) CTGCC(C/G)AGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATAD3B Gene

Variant ID Type Subtype PubMed ID
nsv10161 CNV Gain+Loss 18304495
dgv10n71 CNV Loss 21882294
dgv19n71 CNV Loss 21882294
dgv20n71 CNV Loss 21882294
dgv31n71 CNV Gain 21882294
dgv33n71 CNV Loss 21882294
dgv34n71 CNV Loss 21882294
nsv871837 CNV Loss 21882294
nsv871690 CNV Gain 21882294
essv5472 CNV CNV 17122850
dgv9e1 CNV Complex 17122850
dgv41n71 CNV Gain 21882294
esv2747363 CNV Deletion 23290073
esv2747474 CNV Deletion 23290073
dgv42n71 CNV Loss 21882294
dgv43n71 CNV Loss 21882294
esv2662001 CNV Deletion 23128226
nsv482146 CNV Gain 20164927
esv1254392 CNV Insertion 17803354
esv2661503 CNV Deletion 23128226
esv25832 CNV Loss 19812545
nsv871421 CNV Loss 21882294
nsv871696 CNV Loss 21882294
dgv44n71 CNV Gain+Loss 21882294
nsv871954 CNV Loss 21882294
esv2747585 CNV Deletion 23290073
esv2747696 CNV Deletion 23290073

Relevant External Links for ATAD3B Gene

HapMap Linkage Disequilibrium report
ATAD3B

Disorders for ATAD3B Gene

Relevant External Links for ATAD3B

Genetic Association Database (GAD)
ATAD3B
Human Genome Epidemiology (HuGE) Navigator
ATAD3B
genes like me logo Genes that share disorders with ATAD3B: view

No data available for UniProtKB/Swiss-Prot for ATAD3B Gene

Publications for ATAD3B Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for ATAD3B Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ATAD3B
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ATAD3B
    • Block miRNA regulation of ATAD3B using miScript Target Protectors

    Sources for ATAD3B Gene

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