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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ATAD3A Gene

protein-coding   GIFtS: 49
GCID: GC01P001439

ATPase Family, AAA Domain Containing 3A

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ATPase Family, AAA Domain Containing 3A1 2
ATPase Family AAA Domain-Containing Protein 3A2

External Ids:    HGNC: 255671   Entrez Gene: 552102   Ensembl: ENSG000001977857   OMIM: 6123165   UniProtKB: Q9NVI73   

Export aliases for ATAD3A gene to outside databases

Previous GC identifers: GC01P001387 GC01P001532 GC01P001374 GC01P000720


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ATAD3A Gene:
ATAD3A and ATAD3B (MIM 612317) are mitochondrial membrane proteins that contribute to the stabilization of large
mitochondrial DNA (mtDNA)-protein complexes called nucleoids (He et al., 2007 (PubMed 17210950)).(supplied by
OMIM, Sep 2008)

GeneCards Summary for ATAD3A Gene: 
ATAD3A (ATPase family, AAA domain containing 3A) is a protein-coding gene. Diseases associated with ATAD3A include lung adenocarcinoma, and adenocarcinoma. GO annotations related to this gene include nucleoside-triphosphatase activity and ATP binding. An important paralog of this gene is ATAD3B.

UniProtKB/Swiss-Prot: ATD3A_HUMAN, Q9NVI7
Function: Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism
and cellular level. May play an important in mitochondrial protein synthesis. May also participate in
mitochondrial DNA replication. May bind to mitochondrial DNA D-loops and contribute to nucleoid stability.
Required for enhanced channeling of cholesterol for hormone-dependent steroidogenesis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004350.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ATAD3A gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B2   oct-B3   Arnt   POU2F2   POU2F2C   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATAD3A promoter sequence
   Search SABiosciences Chromatin IP Primers for ATAD3A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATAD3A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.33   Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36.33

ATAD3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATAD3A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P001439:  view genomic region     (about GC identifiers)

Start:
1,447,523 bp from pter      End:
1,470,067 bp from pter
Size:
22,545 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ATD3A_HUMAN, Q9NVI7 (See protein sequence)
Recommended Name: ATPase family AAA domain-containing protein 3A  
Size: 634 amino acids; 71369 Da
Subunit: Can form homooligomers. Homodimer formation at the N-terminus may be regulated by ATP and is required for
the interaction with the inner surface of the mitochondrial outer membrane and correct mitochondrial homeostasis.
Interacts with components of the mitochondrial ribosome and with other proteins involved in mitochondrial RNA
metabolism. May also interact with protein involved in lipid metabolism, including STARD9. May interact with
FAM210A. Interacts with GADD45GIP1. Interacts with S100B in a Ca(+2)- and Zn(+2)-dependent manner; this
interaction probably occurs in the cytosol prior to mitochondrial targeting. S100B could assist ATAD3A
cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. Interacts with
HSP60/HSPD1. Forms heterooligomers with ATAD3B; this interaction may affect ATAD3A activity
Subcellular location: Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion matrix,
mitochondrion nucleoid. Note=In the mitochondrial inner membrane, enriched in sites with the potential to form
contacts with the outer membrane. The N-terminal domain interacts with the inner surface of the mitochondrial
outer membrane and the C-terminal domain localizes in a specific matrix compartment, where it is associated with
nucleoids
Secondary accessions: B3KPB3 D2K8Q1 G3V1I6 Q5SV23 Q8N275 Q96A50
Alternative splicing: 3 isoforms:  Q9NVI7-1   Q9NVI7-2   Q9NVI7-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ATAD3A: NX_Q9NVI7

Explore proteomics data for ATAD3A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NVI7

  • ATAD3A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ATAD3A Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001164006.1  NP_001164007.1  NP_060658.3  

    ENSEMBL proteins: 
     ENSP00000368031   ENSP00000368030   ENSP00000339421   ENSP00000383631   ENSP00000439290  

    Human Recombinant Protein Products for ATAD3A: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ATAD3A 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane IEA--
    GO:0016021integral to membrane IEA--
    GO:0042645mitochondrial nucleoid IEA--

    ATAD3A for ontologies           About GeneDecksing



    ATAD3A Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    AATP: ATPases / AAA-type

    4 InterPro protein domains:
     IPR003959 ATPase_AAA_core
     IPR027417 P-loop_NTPase
     IPR003593 AAA+_ATPase
     IPR021911 DUF3523

    Graphical View of Domain Structure for InterPro Entry Q9NVI7

    ProtoNet protein and cluster: Q9NVI7

    UniProtKB/Swiss-Prot: ATD3A_HUMAN, Q9NVI7
    Domain: The transmembrane domain and a C-terminal adjacent region contain all information necessary for
    mitochondrial targeting (PubMed:20154147)
    Similarity: Belongs to the AAA ATPase family


    ATAD3A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATD3A_HUMAN, Q9NVI7
    Function: Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism
    and cellular level. May play an important in mitochondrial protein synthesis. May also participate in
    mitochondrial DNA replication. May bind to mitochondrial DNA D-loops and contribute to nucleoid stability.
    Required for enhanced channeling of cholesterol for hormone-dependent steroidogenesis
    Induction: Up-regulated by Angiotensin/AGT

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0005524ATP binding IEA--
    GO:0017111nucleoside-triphosphatase activity IEA--
         
    ATAD3A for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Atad3a):
     embryogenesis  growth/size  mortality/aging 

    ATAD3A for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ATAD3A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ATAD3A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ATAD3A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ATAD3A 

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    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATAD3A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ATAD3A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/340 Interacting proteins for ATAD3A (Q9NVI72, 3 ENSP000003680304) via UniProtKB, MINT, STRING, and/or I2D (see all 340)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RIPK3Q9Y5722, 3MINT-49129 I2D: score=2 
    TNFRSF1AP194382, 3MINT-49348 I2D: score=2 
    TNFRSF1BP203332, 3MINT-49433 I2D: score=2 
    TRADDQ156282, 3MINT-49488 I2D: score=2 
    PTP4A3O753653, ENSP000003322744I2D: score=2 STRING: ENSP00000332274
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016049cell growth IMP--
    GO:0043066negative regulation of apoptotic process IMP--

    ATAD3A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ATAD3A (ATD3A)

    Search CenterWatch for drugs/clinical trials and news about ATAD3A / ATD3A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ATAD3A gene (3 alternative transcripts): 
    NM_001170535.1  NM_001170536.1  NM_018188.3  

    Unigene Cluster for ATAD3A:

    ATPase family, AAA domain containing 3A
    Hs.23413  [show with all ESTs]
    Unigene Representative Sequence: NM_018188
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378756(uc001aga.2) ENST00000378755(uc001afz.2) ENST00000339113
    ENST00000439513 ENST00000429957 ENST00000400830 ENST00000536055(uc001agb.2)

    miRNA
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    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATAD3A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATAD3A

    Additional mRNA sequence: 

    AK001571.1 AK025865.1 AK056099.1 AK091144.1 AK092833.1 AK310572.1 BC007803.2 BC011814.2 
    BC014101.2 BC033109.1 BC063607.1 GU189416.1 

    19 DOTS entries:

    DT.100789528  DT.75100599  DT.95265763  DT.100031230  DT.121327937  DT.100031226  DT.121327954  DT.95265774 
    DT.97854639  DT.100789525  DT.100789527  DT.100789530  DT.121327912  DT.121327932  DT.75182947  DT.91769413 
    DT.91897777  DT.92048665  DT.99998976 

    24/466 AceView cDNA sequences (see all 466):

    BM310993 BC018701 BX104486 BG743097 BG695858 BQ642998 AI864051 C20767 
    BU155205 BF312210 BX097516 BU633185 BG740272 AI744345 AW237061 CD672423 
    CF242864 CD557191 CK823587 BQ925983 BC002542 BE561304 BM556227 BI091881 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ATAD3A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCGATCTT
    ATAD3A Expression
    About this image


    See ATAD3A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ATAD3A

    SOURCE GeneReport for Unigene cluster: Hs.23413

    UniProtKB/Swiss-Prot: ATD3A_HUMAN, Q9NVI7
    Tissue specificity: Overexpressed in lung adenocarcinomas (at protein level)

        SABiosciences Custom PCR Arrays for ATAD3A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATAD3A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ATAD3A gene from 10/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atad3a1 , 5 ATPase family, AAA domain containing 3A1, 5 84.14(n)1
    93.23(a)1
      4 (87.20 cM)5
    1088881  NM_179203.31  NP_849534.21 
     1557406415 
    chicken
    (Gallus gallus)
    Aves ATAD3A1 ATPase family, AAA domain containing 3A 77.39(n)
    88.7(a)
      419412  XM_417573.3  XP_417573.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    80(a)
    possible ortholog
    AAWZ02037771(1424-14229)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC686162 hypothetical protein MGC68616 75.23(n)    BC060012.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.257322 Transcribed sequence with moderate similarity to protein more 79.74(n)    CA473917.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta bor1 belphegor 63.8(n)
    63.68(a)
      53565  NM_080257.3  NP_524996.1 
    worm
    (Caenorhabditis elegans)
    Secernentea atad-31 Protein ATAD-3 55.22(n)
    57.57(a)
      174590  NM_063809.5  NP_496210.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPT56
    One of six ATPases of the 19S regulatory particle ...
    17(a)
    1 → many
    XV(545029-546333)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G030601 P-loop containing nucleoside triphosphate hydrolase-like more 47.11(n)
    40.07(a)
      821146  NM_111176.2  NP_186956.2 
    rice
    (Oryza sativa)
    Liliopsida Os02g06976001 hypothetical protein 49.33(n)
    39.42(a)
      4330409  NM_001054356.1  NP_001047821.1 


    ENSEMBL Gene Tree for ATAD3A (if available)
    TreeFam Gene Tree for ATAD3A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ATAD3A gene
    ATAD3B1 2  ATAD3C2  
    3 SIMAP similar genes for ATAD3A using alignment to 3 protein entries:     ATD3A_HUMAN (see all proteins):
    ATAD3B    ATAD3C    DKFZp761L1023

    ATAD3A for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ATAD3A
    PGOHUM00000259546 PGOHUM00000251105


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/845 SNPs in ATAD3A are shown (see all 845)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1849861881,2
    C--718889(+) CATGCC/TGGTGG 2 -- us2k10--------
    rs29865781,2
    --1445582(-) gatctC/Tagctc 2 -- us2k10--------
    rs1818885831,2
    --1445591(+) TCGCAC/TCATTG 2 -- us2k10--------
    rs1448521861,2
    --1445641(+) ATAAAG/TAACCA 2 -- us2k10--------
    rs1479026941,2
    --1445786(+) AACTCA/CTGGGC 2 -- us2k10--------
    rs1856345291,2
    C--1445827(+) ACTGGC/TGGGGT 2 -- us2k10--------
    rs1162727771,2
    C,F--1445849(+) GCCACC/TGCGCC 2 -- us2k12Minor allele frequency- T:0.03WA NA 238
    rs1905047691,2
    --1445924(+) CCAGGG/TTGGAG 3 -- us2k10--------
    rs1134588561,2
    C--1446221(+) TCAGTC/TGCCCA 3 -- us2k13Minor allele frequency- T:0.08CSA WA EA 240
    rs1807349891,2
    --1446305(+) GAACTC/TGAATA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for ATAD3A (1447523 - 1470067 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/24 variations for ATAD3A (see all 24):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2658581CNV Deletion23128226
    esv2747807CNV Deletion23290073
    esv2747696CNV Deletion23290073
    esv2747363CNV Deletion23290073
    nsv871421CNV Loss21882294
    nsv871954CNV Loss21882294
    dgv42n71CNV Loss21882294
    dgv10n71CNV Loss21882294
    dgv34n71CNV Loss21882294
    nsv871837CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612316    OMIM disorders: --

    5 diseases for ATAD3A:    About MalaCards
    lung adenocarcinoma    adenocarcinoma    prostate cancer    prostatitis
    breast cancer


    ATAD3A for disorders           About GeneDecksing

    Genetic Association Database (GAD): ATAD3A
    Human Genome Epidemiology (HuGE) Navigator: ATAD3A (1 document)

    Export disorders for ATAD3A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ATAD3A gene, integrated from 9 sources (see all 45):
    (articles sorted by number of sources associating them with ATAD3A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ATAD3B is a human embryonic stem cell specific mitochondrial protein, re-expressed in cancer cells, that functions as dominant negative for the ubiquitous ATAD3A. (PubMed id 22664726)1, 2 Merle N....Baudier J. (2012)
    2. Topological analysis of ATAD3A insertion in purified human mitochondria. (PubMed id 20349121)1, 2 Hubstenberger A....Rousseau D. (2010)
    3. The calcium-dependent interaction between S100B and t he mitochondrial AAA ATPase ATAD3A and the role of this complex in the cytoplas mic processing of ATAD3A. (PubMed id 20351179)1, 2 Gilquin B....Baudier J. (2010)
    4. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    5. The AAA+ ATPase ATAD3A controls mitochondrial dynamic s at the interface of the inner and outer membranes. (PubMed id 20154147)1, 2 Gilquin B....Baudier J. (2010)
    6. ATPase family AAA domain-containing 3A is a novel ant i-apoptotic factor in lung adenocarcinoma cells. (PubMed id 20332122)1, 2 Fang H.Y....Chow K.C. (2010)
    7. The layered structure of human mitochondrial DNA nucleoids. (PubMed id 18063578)1, 2 Bogenhagen D.F....Burke S. (2008)
    8. The AAA+ protein ATAD3 has displacement loop binding properties and is involved in mitochondrial nucleoid organization. (PubMed id 17210950)1, 2 He J....Holt I.J. (2007)
    9. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55210 HGNC: 25567 AceView: ATAD3AandATAD3BandFLJ37183 Ensembl:ENSG00000197785 euGenes: HUgn55210
    ECgene: ATAD3A H-InvDB: ATAD3A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ATAD3A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ATAD3A gene:
    Search GeneIP for patents involving ATAD3A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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