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Aliases for ATAD2B Gene

Aliases for ATAD2B Gene

  • ATPase Family, AAA Domain Containing 2B 2 3
  • KIAA1240 4 6
  • EC 63
  • EC 63

External Ids for ATAD2B Gene

Previous GeneCards Identifiers for ATAD2B Gene

  • GC02M023825
  • GC02M023971

Summaries for ATAD2B Gene

Entrez Gene Summary for ATAD2B Gene

  • The protein encoded by this gene belongs to the AAA ATPase family. This family member includes an N-terminal bromodomain. It has been found to be localized to the nucleus, partly to replication sites, consistent with a chromatin-related function. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for ATAD2B Gene

ATAD2B (ATPase Family, AAA Domain Containing 2B) is a Protein Coding gene. GO annotations related to this gene include nucleoside-triphosphatase activity and lysine-acetylated histone binding. An important paralog of this gene is ATAD2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATAD2B Gene

Genomics for ATAD2B Gene

Regulatory Elements for ATAD2B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ATAD2B Gene

23,690,576 bp from pter
23,927,114 bp from pter
236,539 bases
Minus strand

Genomic View for ATAD2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATAD2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATAD2B Gene

Proteins for ATAD2B Gene

  • Protein details for ATAD2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ATPase family AAA domain-containing protein 2B
    Protein Accession:
    Secondary Accessions:
    • B9ZVQ5
    • Q6ZNA6
    • Q8N9E7

    Protein attributes for ATAD2B Gene

    1458 amino acids
    Molecular mass:
    164914 Da
    Quaternary structure:
    • Binds acetylated lysine residues in histone H1.4, H2A, H2B, H3 and H4 (in vitro).
    • Sequence=BAD18469.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ATAD2B Gene

    Alternative splice isoforms for ATAD2B Gene


neXtProt entry for ATAD2B Gene

Proteomics data for ATAD2B Gene at MOPED

Selected DME Specific Peptides for ATAD2B Gene

Post-translational modifications for ATAD2B Gene

  • Ubiquitination at Lys447 and Lys478
  • Modification sites at PhosphoSitePlus

Other Protein References for ATAD2B Gene

Domains for ATAD2B Gene

Protein Domains for ATAD2B Gene

Suggested Antigen Peptide Sequences for ATAD2B Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 bromo domain.
  • Belongs to the AAA ATPase family.
  • Contains 1 bromo domain.
  • Belongs to the AAA ATPase family.
genes like me logo Genes that share domains with ATAD2B: view

Function for ATAD2B Gene

Enzyme Numbers (IUBMB) for ATAD2B Gene

Gene Ontology (GO) - Molecular Function for ATAD2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IBA --
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
GO:0016887 ATPase activity IBA --
GO:0070577 lysine-acetylated histone binding IDA 22464331
genes like me logo Genes that share ontologies with ATAD2B: view

Phenotypes for ATAD2B Gene

GenomeRNAi human phenotypes for ATAD2B:
genes like me logo Genes that share phenotypes with ATAD2B: view

Animal Model Products

miRNA for ATAD2B Gene

miRTarBase miRNAs that target ATAD2B

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATAD2B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Animal Models , Transcription Factor Targets and HOMER Transcription for ATAD2B Gene

Localization for ATAD2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATAD2B Gene

Nucleus. Note=Partially localizes to replication sites.

Subcellular locations from

Jensen Localization Image for ATAD2B Gene COMPARTMENTS Subcellular localization image for ATAD2B gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for ATAD2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 24561620
genes like me logo Genes that share ontologies with ATAD2B: view

Pathways for ATAD2B Gene

SuperPathways for ATAD2B Gene

No Data Available

Gene Ontology (GO) - Biological Process for ATAD2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IBA --
GO:0031936 negative regulation of chromatin silencing IBA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with ATAD2B: view

No data available for Pathways by source for ATAD2B Gene

Transcripts for ATAD2B Gene

mRNA/cDNA for ATAD2B Gene

(22) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ATAD2B Gene

ATPase family, AAA domain containing 2B:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATAD2B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATAD2B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b
SP1: - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: -

Relevant External Links for ATAD2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ATAD2B Gene

mRNA expression in normal human tissues for ATAD2B Gene

Protein differential expression in normal tissues for ATAD2B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (33.4), CD8 Tcells (13.0), and Monocytes (9.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATAD2B Gene

SOURCE GeneReport for Unigene cluster for ATAD2B Gene Hs.467862

genes like me logo Genes that share expressions with ATAD2B: view

Expression partners for ATAD2B Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ATAD2B Gene

Orthologs for ATAD2B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATAD2B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ATAD2B 35
  • 94.29 (n)
  • 96.97 (a)
  • 96 (a)
(Canis familiaris)
Mammalia ATAD2B 35
  • 94.68 (n)
  • 96.28 (a)
  • 95 (a)
(Mus musculus)
Mammalia Atad2b 35
  • 88.27 (n)
  • 92.05 (a)
Atad2b 16
Atad2b 36
  • 91 (a)
(Pan troglodytes)
Mammalia ATAD2B 35
  • 99.79 (n)
  • 99.66 (a)
  • 100 (a)
(Monodelphis domestica)
Mammalia ATAD2B 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia ATAD2B 36
  • 89 (a)
(Gallus gallus)
Aves ATAD2B 35
  • 81.24 (n)
  • 86.69 (a)
  • 85 (a)
(Anolis carolinensis)
Reptilia ATAD2B 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia atad2b 35
  • 70.95 (n)
  • 74.91 (a)
Str.7080 35
(Danio rerio)
Actinopterygii atad2b 35
  • 61.8 (n)
  • 63.97 (a)
atad2b 36
  • 60 (a)
(Caenorhabditis elegans)
Secernentea lex-1 36
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YTA7 36
  • 26 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.869 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
Species with no ortholog for ATAD2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATAD2B Gene

Gene Tree for ATAD2B (if available)
Gene Tree for ATAD2B (if available)

Paralogs for ATAD2B Gene

Paralogs for ATAD2B Gene

genes like me logo Genes that share paralogs with ATAD2B: view

Variants for ATAD2B Gene

Sequence variations from dbSNP and Humsavar for ATAD2B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs13419385 -- 23,761,911(+) GGCAT(A/C)TAAAA intron-variant
rs13419431 -- 23,887,173(+) gcagg(A/G)gaatc intron-variant
rs13415783 -- 23,886,119(+) tttat(A/G)ttttt intron-variant
rs13411029 -- 23,723,125(+) catct(C/G)tacaa intron-variant
rs13405614 -- 23,812,713(+) aaaaa(A/T)ttagc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATAD2B Gene

Variant ID Type Subtype PubMed ID
nsv527636 CNV Gain 19592680
nsv2640 CNV Loss 18451855
esv33590 CNV Loss 17666407
nsv214066 CNV Loss 16902084
esv1350131 CNV Insertion 17803354
nsv524917 CNV Loss 19592680
nsv511769 CNV Loss 21212237
esv1080283 CNV Deletion 17803354
nsv507003 CNV Insertion 20534489
esv2659738 CNV Deletion 23128226

Relevant External Links for ATAD2B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATAD2B Gene

Disorders for ATAD2B Gene

No disorders were found for ATAD2B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ATAD2B Gene

Publications for ATAD2B Gene

  1. Histone recognition and large-scale structural analysis of the human bromodomain family. (PMID: 22464331) Filippakopoulos P. … Knapp S. (Cell 2012) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components. (PMID: 24561620) Alabert C. … Groth A. (Nat. Cell Biol. 2014) 3 4
  4. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 3 4
  5. ATAD2B is a phylogenetically conserved nuclear protein expressed during neuronal differentiation and tumorigenesis. (PMID: 21158754) Leachman N.T. … Tucker R.P. (Dev. Growth Differ. 2010) 3

Products for ATAD2B Gene

Sources for ATAD2B Gene

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