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Aliases for ATAD2B Gene

Aliases for ATAD2B Gene

  • ATPase Family, AAA Domain Containing 2B 2 3 5
  • EC 3.5.1.15 61
  • EC 3.6.1.3 61
  • KIAA1240 4

External Ids for ATAD2B Gene

Previous GeneCards Identifiers for ATAD2B Gene

  • GC02M023825
  • GC02M023971

Summaries for ATAD2B Gene

Entrez Gene Summary for ATAD2B Gene

  • The protein encoded by this gene belongs to the AAA ATPase family. This family member includes an N-terminal bromodomain. It has been found to be localized to the nucleus, partly to replication sites, consistent with a chromatin-related function. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for ATAD2B Gene

ATAD2B (ATPase Family, AAA Domain Containing 2B) is a Protein Coding gene. GO annotations related to this gene include chromatin binding and lysine-acetylated histone binding. An important paralog of this gene is ATAD2.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATAD2B Gene

Genomics for ATAD2B Gene

Regulatory Elements for ATAD2B Gene

Enhancers for ATAD2B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G023900 1.3 Ensembl ENCODE 17.7 +25.6 25628 2.8 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF143 ZNF207 UBXN2A ATAD2B FAM228B SF3B6 PFN4 RPS13P4
GH02G024268 1.6 FANTOM5 Ensembl ENCODE 6.6 -342.3 -342329 1.4 HDGF ATF1 FOXA2 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 GLIS2 ZNF143 ATAD2B ITSN2 FAM228A NCOA1 ENSG00000251805 GC02M024275 PIR61843
GH02G024009 1.6 FANTOM5 ENCODE dbSUPER 6.4 -84.3 -84341 4.1 HDGF PKNOX1 CREB3L1 ARNT ZFP64 YY1 ZNF766 ZNF592 MEF2D SMARCA4 MFSD2B UBXN2A ATAD2B RNU6-370P
GH02G023824 0.9 ENCODE 11.1 +102.2 102229 0.2 HDGF PKNOX1 ATF1 CREB3L1 DMAP1 YY1 ELK1 ZNF143 CEBPZ NFYC WDCP ATAD2B UBXN2A FAM228B SF3B6 MFSD2B PFN4 PGAM1P6 GC02P023754
GH02G024048 0.9 ENCODE 10.7 -122.7 -122688 1.6 AGO1 ARID4B ZNF2 ZNF48 ZNF121 GLIS2 GATA2 FOS SP3 SP5 FAM228B SF3B6 MFSD2B TP53I3 ATAD2B UBXN2A PFN4 FKBP1B PIR43014 GC02M024079
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ATAD2B on UCSC Golden Path with GeneCards custom track

Promoters for ATAD2B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000114000 514 3201 HDGF PKNOX1 ARNT CREB3L1 AGO1 ZFP64 WRNIP1 ARID4B SIN3A FEZF1

Genomic Location for ATAD2B Gene

Chromosome:
2
Start:
23,685,229 bp from pter
End:
23,927,114 bp from pter
Size:
241,886 bases
Orientation:
Minus strand

Genomic View for ATAD2B Gene

Genes around ATAD2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATAD2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATAD2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATAD2B Gene

Proteins for ATAD2B Gene

  • Protein details for ATAD2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULI0-ATD2B_HUMAN
    Recommended name:
    ATPase family AAA domain-containing protein 2B
    Protein Accession:
    Q9ULI0
    Secondary Accessions:
    • B9ZVQ5
    • Q6ZNA6
    • Q8N9E7

    Protein attributes for ATAD2B Gene

    Size:
    1458 amino acids
    Molecular mass:
    164914 Da
    Quaternary structure:
    • Binds acetylated lysine residues in histone H1.4, H2A, H2B, H3 and H4 (in vitro).
    SequenceCaution:
    • Sequence=BAD18469.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ATAD2B Gene

    Alternative splice isoforms for ATAD2B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATAD2B Gene

Selected DME Specific Peptides for ATAD2B Gene

Q9ULI0:
  • TLILEDS
  • LFYGPPG

Post-translational modifications for ATAD2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for ATAD2B Gene

Gene Families for ATAD2B Gene

Suggested Antigen Peptide Sequences for ATAD2B Gene

Graphical View of Domain Structure for InterPro Entry

Q9ULI0

UniProtKB/Swiss-Prot:

ATD2B_HUMAN :
  • Belongs to the AAA ATPase family.
Family:
  • Belongs to the AAA ATPase family.
genes like me logo Genes that share domains with ATAD2B: view

Function for ATAD2B Gene

Enzyme Numbers (IUBMB) for ATAD2B Gene

Gene Ontology (GO) - Molecular Function for ATAD2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IBA --
GO:0005524 ATP binding IEA --
GO:0016887 ATPase activity IBA --
GO:0070577 lysine-acetylated histone binding IDA 22464331
genes like me logo Genes that share ontologies with ATAD2B: view
genes like me logo Genes that share phenotypes with ATAD2B: view

Animal Models for ATAD2B Gene

MGI Knock Outs for ATAD2B:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ATAD2B Gene

Localization for ATAD2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATAD2B Gene

Nucleus. Note=Partially localizes to replication sites.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATAD2B gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ATAD2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 24561620
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ATAD2B: view

Pathways & Interactions for ATAD2B Gene

SuperPathways for ATAD2B Gene

No Data Available

Gene Ontology (GO) - Biological Process for ATAD2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031936 negative regulation of chromatin silencing IBA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with ATAD2B: view

No data available for Pathways by source and SIGNOR curated interactions for ATAD2B Gene

Drugs & Compounds for ATAD2B Gene

No Compound Related Data Available

Transcripts for ATAD2B Gene

mRNA/cDNA for ATAD2B Gene

(17) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ATAD2B Gene

ATPase family, AAA domain containing 2B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATAD2B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b
SP1: - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: -
SP5:

Relevant External Links for ATAD2B Gene

GeneLoc Exon Structure for
ATAD2B
ECgene alternative splicing isoforms for
ATAD2B

Expression for ATAD2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ATAD2B Gene

Protein differential expression in normal tissues from HIPED for ATAD2B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (33.4), CD8 Tcells (13.0), and Monocytes (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ATAD2B Gene



Protein tissue co-expression partners for ATAD2B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ATAD2B Gene:

ATAD2B

SOURCE GeneReport for Unigene cluster for ATAD2B Gene:

Hs.467862

Evidence on tissue expression from TISSUES for ATAD2B Gene

  • Liver(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ATAD2B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATAD2B Gene

Orthologs for ATAD2B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATAD2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATAD2B 34 35
  • 99.79 (n)
dog
(Canis familiaris)
Mammalia ATAD2B 34 35
  • 94.68 (n)
cow
(Bos Taurus)
Mammalia ATAD2B 34 35
  • 94.29 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ATAD2B 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atad2b 34 16 35
  • 88.27 (n)
oppossum
(Monodelphis domestica)
Mammalia ATAD2B 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATAD2B 34 35
  • 81.24 (n)
lizard
(Anolis carolinensis)
Reptilia ATAD2B 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atad2b 34
  • 70.95 (n)
Str.7080 34
zebrafish
(Danio rerio)
Actinopterygii atad2b 34 35
  • 61.8 (n)
worm
(Caenorhabditis elegans)
Secernentea lex-1 35
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YTA7 35
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 49 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.869 34
Species where no ortholog for ATAD2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATAD2B Gene

ENSEMBL:
Gene Tree for ATAD2B (if available)
TreeFam:
Gene Tree for ATAD2B (if available)

Paralogs for ATAD2B Gene

Paralogs for ATAD2B Gene

genes like me logo Genes that share paralogs with ATAD2B: view

Variants for ATAD2B Gene

Sequence variations from dbSNP and Humsavar for ATAD2B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000006475 -- 23,773,456(+) TATGA(G/T)GGCTA intron-variant, utr-variant-3-prime
rs1000021922 -- 23,903,661(+) CTTCA(G/T)GCCCA intron-variant
rs1000043481 -- 23,882,598(+) GGTCA(A/G)GAGAT intron-variant
rs1000075843 -- 23,697,369(+) CTTTT(A/G)GAGAA intron-variant
rs1000087184 -- 23,771,177(+) CTTAC(A/G)TGTTC intron-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ATAD2B Gene

Variant ID Type Subtype PubMed ID
dgv3741n100 CNV loss 25217958
esv1080283 CNV deletion 17803354
esv1350131 CNV insertion 17803354
esv2659738 CNV deletion 23128226
esv33590 CNV loss 17666407
esv3553789 CNV deletion 23714750
esv3583668 CNV loss 25503493
esv3590060 CNV loss 21293372
nsv1004502 CNV gain 25217958
nsv1008906 CNV loss 25217958
nsv1143933 CNV deletion 24896259
nsv214066 CNV deletion 16902084
nsv2640 CNV deletion 18451855
nsv507003 OTHER sequence alteration 20534489
nsv511769 CNV loss 21212237
nsv524917 CNV loss 19592680
nsv527636 CNV gain 19592680
nsv961018 CNV duplication 23825009
nsv997445 CNV gain 25217958

Variation tolerance for ATAD2B Gene

Residual Variation Intolerance Score: 18.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.51; 55.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATAD2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATAD2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATAD2B Gene

Disorders for ATAD2B Gene

Relevant External Links for ATAD2B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATAD2B

No disorders were found for ATAD2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATAD2B Gene

Publications for ATAD2B Gene

  1. Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components. (PMID: 24561620) Alabert C. … Groth A. (Nat. Cell Biol. 2014) 3 4 64
  2. Histone recognition and large-scale structural analysis of the human bromodomain family. (PMID: 22464331) Filippakopoulos P. … Knapp S. (Cell 2012) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 3 4 64
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64

Products for ATAD2B Gene

Sources for ATAD2B Gene

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