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Aliases & Descriptions for ATAD2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| ANCCA 2, 3, 5 | | DKFZp667N1320 1, 2 | | EC 3.6.1.3 3 | | MGC131938 2 | | MGC142216 2 | | MGC29843 1, 2 | | MGC5254 1, 2 | | PRO2000 1, 2 |
| | | Descriptions |
|---|
| AAA nuclear coregulator cancer-associated protein 3 | | ATPase family, AAA domain containing 2 2 |
|
| | Search outside databases for aliases for ATAD2 genePrevious GC identifer: GC08M124292 |
Summaries for ATAD2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for ATAD2: A large family of ATPases has been described, whose key feature is that they share a conserved region of about 220 amino acids that contains an ATP-binding site. The proteins that belong to this family either contain one or two AAA (ATPases Associated with diverse cellular Activities) domains. AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. The protein encoded by this gene contains two AAA domains, as well as a bromodomain. [provided by RefSeq] UniProtKB/Swiss-Prot: ATAD2_HUMAN, Q6PL18Function: May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells |
Genomic Location for ATAD2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the ATAD2 gene 
Entrez Gene cytogenetic band: 8q24.13 Ensembl cytogenetic band: 8q24.13 HGNC cytogenetic band: 8q24.13ATAD2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M124401:
(about GC identifiers)
Start:
|
124,401,922 bp from pter |
End:
|
124,477,868 bp from pter |
Size:
|
75,947 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000008.9 NT_008046.15
| Proteins for ATAD2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: ATAD2_HUMAN, Q6PL18 (See
protein sequence)Recommended Name: ATPase family AAA domain-containing protein 2 Size: 1390 amino acids; 158554 Da
Subunit: Interacts with ESR1 and NCOA3 and these interactions are enhanced by estradiol
Subcellular location: Nucleus
Sequence caution: Sequence=AAH10686.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part (676-679);
PDB structures from and Proteopedia :3DAI (3D)
 
Secondary accessions: Q14CR1 Q658P2 Q68CQ0 Q6PJV6 Q8N890 Q9UHS5Alternative splicing: 2 isoforms: Q6PL18-1 Q6PL18-2 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_054828.2
ENSEMBL proteins: ENSP00000287394
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- | About this table
Antibodies for ATAD2: Assays for ATAD2: | Protein
Domains/ Families for ATAD2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q6PL18
ProtoNet protein and cluster: Q6PL18 2 Blocks protein families: IPB001487 Bromodomain signature IPB003960 AAA-protein subdomain
UniProtKB/Swiss-Prot: ATAD2_HUMAN, Q6PL18Similarity: Belongs to the AAA ATPase familySimilarity: Contains 1 bromo domain | Gene Function for ATAD2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014109
Applied Biosystems Silencer® siRNAs for ATAD2
Sigma-Aldrich siRNA for ATAD2  Sigma-Aldrich shRNA for ATAD2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014109                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014109                                  untagged cDNA clones in CMV expression vector (see all 2): BC007123 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_014109
UniProtKB/Swiss-Prot: ATAD2_HUMAN, Q6PL18Function: May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cellsCatalytic activity: ATP + H(2)O = ADP + phosphateInduction: Up-regulated in breast, uterus, colon, ovary, and stomach tumors. Induced in breast cancer cells overexpressing NCOA3 or treated with estrogen. Down-regulated in 5-fluorouracil-resistant derivatives of the colon cancer cell line HCT116Enzyme Number (IUBMB): EC 3.6.1.3 5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6
): About this table | Pathways & Interactions for ATAD2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
2 Interacting proteins for ATAD2 (ENSP000002873943) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | About this table
|
Drugs & Compounds for ATAD2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for ATAD2
|
Transcripts for ATAD2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014109
Sigma-Aldrich siRNA for ATAD2  Sigma-Aldrich shRNA for ATAD2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_014109 REFSEQ mRNAs for ATAD2 gene: NM_014109.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_014109               OriGene GFP tagged cDNA clone in CMV expression vector: NM_014109                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014109                                  untagged cDNA clones in CMV expression vector (see all 2): BC007123  Additional cDNA sequence: AF118088.1 AK097133.1 AL833653.1 AY598335.1 BC010686.1 BC019909.1 BC112942.1 BC113656.1 BC143716.1 CR749832.1 12 DOTS entries: DT.441446 DT.100777335 DT.91750028 DT.100777333 DT.121485529 DT.422400 DT.100655985 DT.121485560 DT.91734891 DT.91862825 DT.92022435 DT.95367627 24/170 AceView cDNA sequences (see all 170
):AA808229 AA995158 AI133393 AL833653 AA287933 BX643073 BQ425008 AA897632 CB120155 CB159561 BC007123 AF118088 NM_014109 AK097133 AW168205 BQ896166 AW151919 CB161159 CD244182 AI240868 BI861220 BM014842 BP356240 BM559313
highest scoring ESTs for ATAD2:AA451665 AA355899 AA455762 AA522645 AA974408 AA995158 AL556876 BE504612 BE541451 BF062930 Unigene Cluster for ATAD2: ATPase family, AAA domain containing 2 Hs.370834 [show with all ESTs]Unigene Representative Sequence: NM_014109
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for ATAD2 (see all 12
)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b | · | 16c | · | 16d | ^ | 17a | · | |
| SP1: | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 17b | · | 17c | ^ | 18a | · | 18b | ^ | 19a | · | 19b | ^ | 20 | ^ | 21a | · | 21b | · | 21c | ^ | 22a | · | 22b | ^ | 23 | ^ | 24a | · | 24b | ^ | 25 | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for ATAD2
1 Ensembl transcript including schematic representation: ENST00000287394
|
Expression for ATAD2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| ATAD2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for ATAD2
1 / 2 / 3 13 probe-sets matching ATAD2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: ATTTGCGGGA
SOURCE GeneReport for Unigene cluster: Hs.370834 UniProtKB/Swiss-Prot: ATAD2_HUMAN, Q6PL18Tissue specificity: Highly expressed in estrogen receptor positive breast tumors and in osteosarcoma tumors |
Orthologs for ATAD2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ATAD2 gene from 5/15 species (see all 15
)
About this table Species with no ortholog for ATAD2
ENSEMBL Gene Tree for ATAD2 | Paralogs for ATAD2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for ATAD2 gene
- ATAD2B2 ATAD12
|
SNPs/Variants for ATAD2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for ATAD2 (up to first 250kb)
|
Disorders & Mutations for ATAD2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 611941
|
Medical News for ATAD2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for ATAD2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/16 PubMed articles for ATAD2 gene (see all 16
):- ANCCA, an estrogen-regulated AAA+ ATPase coactivator for ERalpha, is required for coregulator occupancy and chromatin modification. (PubMed id 17998543)3, 4 Zou J.X....Chen H.W. (2007)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PubMed id 15334068)3, 4 Petroziello J.... Carter P. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)3, 4 Beausoleil S.A....Gygi S.P. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)2, 3 Strausberg R.L....Marra M.A. (2002)
- Androgen-induced coactivator ANCCA mediates specific androgen receptor signaling in prostate cancer. (PubMed id 19318566)3 Zou J.X....Chen H.W. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)4 Dephoure N.... Gygi S.P. (2008)
- Prognostic significance of drug-regulated genes in high-grade osteosarcoma. (PubMed id 17660802)4 Fellenberg J....Zahlten-Hinguranage A. (2007)
|
Search for ATAD2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ATAD2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing ATAD2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ATAD2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for ATAD2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for ATAD2:

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Incremental update: 13 Oct 2009
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