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Aliases for ATAD2 Gene

Aliases for ATAD2 Gene

  • ATPase Family, AAA Domain Containing 2 2 3 5
  • AAA Nuclear Coregulator Cancer-Associated Protein 3 4
  • ANCCA 3 4
  • ATPase Family AAA Domain-Containing Protein 2 3
  • EC 3.6.1.3 4
  • PRO2000 3
  • CT137 3

External Ids for ATAD2 Gene

Previous GeneCards Identifiers for ATAD2 Gene

  • GC08M124292
  • GC08M124401
  • GC08M119657
  • GC08M124332

Summaries for ATAD2 Gene

Entrez Gene Summary for ATAD2 Gene

  • A large family of ATPases has been described, whose key feature is that they share a conserved region of about 220 amino acids that contains an ATP-binding site. The proteins that belong to this family either contain one or two AAA (ATPases Associated with diverse cellular Activities) domains. AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. The protein encoded by this gene contains two AAA domains, as well as a bromodomain. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATAD2 Gene

ATAD2 (ATPase Family, AAA Domain Containing 2) is a Protein Coding gene. Among its related pathways are Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors and Gene Expression. GO annotations related to this gene include chromatin binding and histone binding. An important paralog of this gene is ATAD2B.

UniProtKB/Swiss-Prot for ATAD2 Gene

  • May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATAD2 Gene

Genomics for ATAD2 Gene

Regulatory Elements for ATAD2 Gene

Enhancers for ATAD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F123386 1 Ensembl ENCODE 11.6 +29.2 29150 2.4 OSR2 IRF2 GATA3 MTA2 IKZF1 EBF1 IRF1 PRDM1 SPI1 WDYHV1 DUTP2 MIR548AA1 RNU6-875P ATAD2 FAM91A1 IMPDH1P6 GC08M123342
GH08F123462 0.9 Ensembl ENCODE 11.6 -46.6 -46596 0.3 HDGF ATF1 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 YY1 NCOA1 REST TRMT12 ATAD2 WDYHV1 ANXA13 FBXO32 DUTP2 MIR548AA1 RNU6-875P ENSG00000278374 GC08M123499
GH08F123460 0.9 ENCODE 11.6 -45.1 -45104 1.0 ARNT CREB3L1 SIN3A DMAP1 RCOR1 ZBTB11 REST ZNF592 SMARCA4 IKZF1 WDYHV1 ATAD2 ANXA13 FBXO32 DUTP2 MIR548AA1 RNU6-875P ENSG00000278374 GC08M123499
GH08F123465 1 Ensembl ENCODE 11.2 -50.5 -50453 1.9 SOX13 ARID4B ZNF384 CEBPG ZNF644 ZBTB40 NR2F6 GATAD2A CEBPB NFIL3 WDYHV1 ATAD2 FBXO32 ENSG00000278374 GC08M123499
GH08F123471 1.1 Ensembl ENCODE 11.1 -58.6 -58617 6.9 PKNOX1 INSM2 SIN3A THRB RAD21 SCRT2 FOS SMAD5 ZEB2 ZNF843 WDYHV1 FBXO32 ATAD2 LOC105375738 FAM91A1 FAM83A-AS1 MIR548AA1 DUTP2 RNU6-875P FAM83A
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ATAD2 on UCSC Golden Path with GeneCards custom track

Promoters for ATAD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001400598 -350 2201 HDGF ATF1 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 YY1 GLIS2 ELK1

Genomic Location for ATAD2 Gene

Chromosome:
8
Start:
123,319,850 bp from pter
End:
123,416,350 bp from pter
Size:
96,501 bases
Orientation:
Minus strand

Genomic View for ATAD2 Gene

Genes around ATAD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATAD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATAD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATAD2 Gene

Proteins for ATAD2 Gene

  • Protein details for ATAD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PL18-ATAD2_HUMAN
    Recommended name:
    ATPase family AAA domain-containing protein 2
    Protein Accession:
    Q6PL18
    Secondary Accessions:
    • Q14CR1
    • Q658P2
    • Q68CQ0
    • Q6PJV6
    • Q8N890
    • Q9UHS5

    Protein attributes for ATAD2 Gene

    Size:
    1390 amino acids
    Molecular mass:
    158554 Da
    Quaternary structure:
    • Interacts with ESR1 and NCOA3 and these interactions are enhanced by estradiol. Interacts with acetylated lysine residues on histone H1.4, H2A, H2B and H3 (in vitro).
    SequenceCaution:
    • Sequence=AAF22032.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH10686.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part (676-679).; Evidence={ECO:0000305}; Sequence=AAH19909.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ATAD2 Gene

    Alternative splice isoforms for ATAD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATAD2 Gene

Post-translational modifications for ATAD2 Gene

  • Ubiquitination at Lys 175, Lys 311, Lys 489, Lys 931, and Lys 1042
  • Modification sites at PhosphoSitePlus

Other Protein References for ATAD2 Gene

No data available for DME Specific Peptides for ATAD2 Gene

Domains & Families for ATAD2 Gene

Gene Families for ATAD2 Gene

Suggested Antigen Peptide Sequences for ATAD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PL18

UniProtKB/Swiss-Prot:

ATAD2_HUMAN :
  • Contains 1 bromo domain.
  • Belongs to the AAA ATPase family.
Domain:
  • Contains 1 bromo domain.
Family:
  • Belongs to the AAA ATPase family.
genes like me logo Genes that share domains with ATAD2: view

Function for ATAD2 Gene

Molecular function for ATAD2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.
UniProtKB/Swiss-Prot Induction:
Up-regulated in breast, uterus, colon, ovary, and stomach tumors. Induced in breast cancer cells overexpressing NCOA3 or treated with estrogen. Down-regulated in 5-fluorouracil-resistant derivatives of the colon cancer cell line HCT 116.

Enzyme Numbers (IUBMB) for ATAD2 Gene

Gene Ontology (GO) - Molecular Function for ATAD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IBA --
GO:0005524 ATP binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0016887 ATPase activity IEA,IDA 17998543
GO:0042393 histone binding IBA --
genes like me logo Genes that share ontologies with ATAD2: view

Phenotypes for ATAD2 Gene

genes like me logo Genes that share phenotypes with ATAD2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ATAD2

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATAD2 Gene

Localization for ATAD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATAD2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATAD2 Gene COMPARTMENTS Subcellular localization image for ATAD2 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for ATAD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
GO:0005654 nucleoplasm IDA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with ATAD2: view

Pathways & Interactions for ATAD2 Gene

genes like me logo Genes that share pathways with ATAD2: view

Gene Ontology (GO) - Biological Process for ATAD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0031936 negative regulation of chromatin silencing IBA --
GO:0045893 positive regulation of transcription, DNA-templated IDA 17998543
genes like me logo Genes that share ontologies with ATAD2: view

No data available for SIGNOR curated interactions for ATAD2 Gene

Drugs & Compounds for ATAD2 Gene

(3) Drugs for ATAD2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for ATAD2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with ATAD2: view

Transcripts for ATAD2 Gene

Unigene Clusters for ATAD2 Gene

ATPase family, AAA domain containing 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ATAD2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATAD2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c · 16d ^ 17a ·
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

ExUns: 17b · 17c ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21a · 21b · 21c ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -

Relevant External Links for ATAD2 Gene

GeneLoc Exon Structure for
ATAD2
ECgene alternative splicing isoforms for
ATAD2

Expression for ATAD2 Gene

mRNA expression in normal human tissues for ATAD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ATAD2 Gene

This gene is overexpressed in Lung (21.7), Testis (17.3), Ovary (12.6), and Synovial fluid (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ATAD2 Gene



NURSA nuclear receptor signaling pathways regulating expression of ATAD2 Gene:

ATAD2

SOURCE GeneReport for Unigene cluster for ATAD2 Gene:

Hs.370834

mRNA Expression by UniProt/SwissProt for ATAD2 Gene:

Q6PL18-ATAD2_HUMAN
Tissue specificity: Highly expressed in estrogen receptor positive breast tumors and in osteosarcoma tumors.
genes like me logo Genes that share expression patterns with ATAD2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for ATAD2 Gene

Orthologs for ATAD2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATAD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATAD2 34 35
  • 99.16 (n)
dog
(Canis familiaris)
Mammalia ATAD2 34 35
  • 91.63 (n)
cow
(Bos Taurus)
Mammalia ATAD2 35
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atad2 34
  • 86.02 (n)
mouse
(Mus musculus)
Mammalia Atad2 34 16 35
  • 85.27 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ATAD2 35
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATAD2 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATAD2 34 35
  • 66.64 (n)
lizard
(Anolis carolinensis)
Reptilia ATAD2 35
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atad2 34
  • 67.29 (n)
Str.3073 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.25675 34
zebrafish
(Danio rerio)
Actinopterygii wu:fi16e04 34
  • 60.11 (n)
ATAD2 35
  • 54 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea lex-1 35
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YTA7 35 37
  • 23 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.8886 34
corn
(Zea mays)
Liliopsida Zm.12719 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 50 (a)
OneToMany
Species where no ortholog for ATAD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATAD2 Gene

ENSEMBL:
Gene Tree for ATAD2 (if available)
TreeFam:
Gene Tree for ATAD2 (if available)

Paralogs for ATAD2 Gene

Paralogs for ATAD2 Gene

(6) SIMAP similar genes for ATAD2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ATAD2: view

Variants for ATAD2 Gene

Sequence variations from dbSNP and Humsavar for ATAD2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10087057 -- 123,374,542(+) GAACC(A/G)CCCAC intron-variant
rs10089462 -- 123,378,191(+) tactg(C/T)cagtg intron-variant
rs10089968 -- 123,360,585(+) AAATA(A/T)TCAGA intron-variant
rs10099639 -- 123,329,729(+) cttgc(A/G)tgacg intron-variant
rs10099717 -- 123,329,981(+) GGCtt(C/T)ttttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATAD2 Gene

Variant ID Type Subtype PubMed ID
esv3572974 CNV loss 25503493
nsv1109989 CNV deletion 24896259
nsv831449 CNV loss 17160897

Variation tolerance for ATAD2 Gene

Residual Variation Intolerance Score: 2.19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.68; 46.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATAD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATAD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATAD2 Gene

Disorders for ATAD2 Gene

Relevant External Links for ATAD2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATAD2

No disorders were found for ATAD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATAD2 Gene

Publications for ATAD2 Gene

  1. ANCCA, an estrogen-regulated AAA+ ATPase coactivator for ERalpha, is required for coregulator occupancy and chromatin modification. (PMID: 17998543) Zou J.X. … Chen H.-W. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 4 64
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PMID: 15334068) Petroziello J. … Carter P. (Oncogene 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for ATAD2 Gene

Sources for ATAD2 Gene

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