Aliases for ATAD2 Gene
External Ids for ATAD2 Gene
Previous GeneCards Identifiers for ATAD2 Gene
A large family of ATPases has been described, whose key feature is that they share a conserved region of about 220 amino acids that contains an ATP-binding site. The proteins that belong to this family either contain one or two AAA (ATPases Associated with diverse cellular Activities) domains. AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. The protein encoded by this gene contains two AAA domains, as well as a bromodomain. [provided by RefSeq, Jul 2008]
GeneCards Summary for ATAD2 Gene
ATAD2 (ATPase Family, AAA Domain Containing 2) is a Protein Coding gene. Among its related pathways are Gastric cancer network 2. GO annotations related to this gene include chromatin binding and histone binding. An important paralog of this gene is ATAD2B.
UniProtKB/Swiss-Prot for ATAD2 Gene
May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.