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ATAD2 Gene

protein-coding   GIFtS: 53
GCID: GC08M124332

ATPase Family, AAA Domain Containing 2

Pneumococci & Pneumococcal Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ATPase Family, AAA Domain Containing 21 2     PRO20002
ANCCA2 3 5     ATPase Family AAA Domain-Containing Protein 22
AAA Nuclear Coregulator Cancer-Associated Protein2 3     EC 3.6.1.33
CT1372     

External Ids:    HGNC: 301231   Entrez Gene: 290282   Ensembl: ENSG000001568027   OMIM: 6119415   UniProtKB: Q6PL183   

Export aliases for ATAD2 gene to outside databases

Previous GC identifers: GC08M124292 GC08M124401 GC08M119657


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ATAD2 Gene:
A large family of ATPases has been described, whose key feature is that they share a conserved region of about 220
amino acids that contains an ATP-binding site. The proteins that belong to this family either contain one or two
AAA (ATPases Associated with diverse cellular Activities) domains. AAA family proteins often perform
chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. The protein
encoded by this gene contains two AAA domains, as well as a bromodomain. (provided by RefSeq, Jul 2008)

GeneCards Summary for ATAD2 Gene:
ATAD2 (ATPase family, AAA domain containing 2) is a protein-coding gene. Diseases associated with ATAD2 include anogenital venereal wart, and genital herpes. GO annotations related to this gene include ATPase activity. An important paralog of this gene is ATAD2B.

UniProtKB/Swiss-Prot: ATAD2_HUMAN, Q6PL18
Function: May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a
subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of
CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the
estrogen-induced cell proliferation and cell cycle progression of breast cancer cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_008046.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ATAD2 gene promoter:
         AML1a   p53   RREB-1   CREB   HEN1   POU2F1   FOXO4   POU2F1a   deltaCREB   ZIC2/Zic2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATAD2 promoter sequence
   Search Chromatin IP Primers for ATAD2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATAD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.13   Ensembl cytogenetic band:  8q24.13   HGNC cytogenetic band: 8q24.13

ATAD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATAD2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M124332:  view genomic region     (about GC identifiers)

Start:
124,332,090 bp from pter      End:
124,428,590 bp from pter
Size:
96,501 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ATAD2_HUMAN, Q6PL18 (See protein sequence)
Recommended Name: ATPase family AAA domain-containing protein 2  
Size: 1390 amino acids; 158554 Da
Subunit: Interacts with ESR1 and NCOA3 and these interactions are enhanced by estradiol. Interacts with acetylated
lysine residues on histone H1.4, H2A, H2B and H3 (in vitro)
Sequence caution: Sequence=AAF22032.1; Type=Erroneous initiation; Sequence=AAH10686.1; Type=Miscellaneous
discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part (676-679);
Sequence=AAH19909.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for ATAD2:
3DAI (3D)    
Secondary accessions: Q14CR1 Q658P2 Q68CQ0 Q6PJV6 Q8N890 Q9UHS5
Alternative splicing: 2 isoforms:  Q6PL18-1   Q6PL18-2   (No experimental confirmation available. Dubious isoform. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for ATAD2: NX_Q6PL18

Explore proteomics data for ATAD2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys175, Lys311, Lys473, Lys489, Lys504, Lys931, Lys1042
  • Modification sites at PhosphoSitePlus

  • See ATAD2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_054828.2  
    ENSEMBL proteins: 
     ENSP00000429331   ENSP00000287394   ENSP00000429213   ENSP00000429617  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    AATP: ATPases / AAA-type

    Selected InterPro protein domains (see all 6):
     IPR003959 ATPase_AAA_core
     IPR011989 ARM-like
     IPR003960 ATPase_AAA_CS
     IPR027417 P-loop_NTPase
     IPR001487 Bromodomain

    Graphical View of Domain Structure for InterPro Entry Q6PL18

    ProtoNet protein and cluster: Q6PL18

    2 Blocks protein domains:
    IPB001487 Bromodomain signature
    IPB003960 AAA-protein subdomain


    UniProtKB/Swiss-Prot: ATAD2_HUMAN, Q6PL18
    Similarity: Belongs to the AAA ATPase family
    Similarity: Contains 1 bromo domain


    ATAD2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATAD2_HUMAN, Q6PL18
    Function: May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a
    subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of
    CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the
    estrogen-induced cell proliferation and cell cycle progression of breast cancer cells
    Catalytic activity: ATP + H(2)O = ADP + phosphate
    Induction: Up-regulated in breast, uterus, colon, ovary, and stomach tumors. Induced in breast cancer cells
    overexpressing NCOA3 or treated with estrogen. Down-regulated in 5-fluorouracil-resistant derivatives of the
    colon cancer cell line HCT 116

         Enzyme Number (IUBMB): EC 3.6.1.31

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
    GO:0016887ATPase activity IDA17998543
    GO:0017111nucleoside-triphosphatase activity ----
         
    ATAD2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ATAD2
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    miRTarBase miRNAs that target ATAD2:
    hsa-mir-941 (MIRT036581), hsa-mir-106b-5p (MIRT020472), hsa-mir-193b-3p (MIRT041465), hsa-mir-215-5p (MIRT024263), hsa-mir-192-5p (MIRT026860), hsa-mir-17-3p (MIRT050753)

    Block miRNA regulation of human, mouse, rat ATAD2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ATAD2 (see all 43):
    hsa-miR-548j hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-106a hsa-miR-374a hsa-miR-374a* hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidATAD2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ATAD2

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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATAD2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATAD2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ATAD2_HUMAN, Q6PL18: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    cytoskeleton1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    ATAD2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ATAD2 About    
    See pathways by source

    SuperPathContained pathways About
    1Gastric cancer network 2
    Gastric cancer network 2


    1 BioSystems Pathway for ATAD2
        Gastric cancer network 2


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ATAD2
    Interactions:

        Search GeneGlobe Interaction Network for ATAD2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ATAD2 (Q6PL183 ENSP000002873944) via UniProtKB, MINT, STRING, and/or I2D (see all 264)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4HP628053, ENSP000002893524I2D: score=5 STRING: ENSP00000289352
    HIST2H4AP628053, ENSP000003581624I2D: score=5 STRING: ENSP00000358162
    HIST1H4FP628053, ENSP000003669744I2D: score=5 STRING: ENSP00000366974
    HIST1H4AP628053I2D: score=5 
    HIST1H4BP628053I2D: score=5 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006200ATP catabolic process IDA17998543
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0045893positive regulation of transcription, DNA-templated IDA17998543

    ATAD2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ATAD2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ATAD2 gene: 
    NM_014109.3  

    Unigene Cluster for ATAD2:

    ATPase family, AAA domain containing 2
    Hs.370834  [show with all ESTs]
    Unigene Representative Sequence: NM_014109
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000517666 ENST00000287394(uc011lii.2 uc003yqh.4 uc003yqi.4)
    ENST00000521903 ENST00000519124 ENST00000521496(uc003yqj.3) ENST00000550993
    ENST00000534257 ENST00000530065

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ATAD2 (see all 43):
    hsa-miR-548j hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-106a hsa-miR-374a hsa-miR-374a* hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidATAD2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ATAD2
    Predesigned siRNA for gene silencing in human, mouse, rat ATAD2
    Clone
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    OriGene clones in human, mouse for ATAD2 (see all 6)
    OriGene ORF clones in mouse, rat for ATAD2
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    GenScript: all cDNA clones in your preferred vector: ATAD2 (NM_014109)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATAD2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ATAD2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ATAD2
      QuantiTect SYBR Green Assays in human, mouse, rat ATAD2
      QuantiFast Probe-based Assays in human, mouse, rat ATAD2

    Additional mRNA sequence: 

    AF118088.1 AK097133.1 AL833653.1 AY598335.1 BC010686.1 BC019909.1 BC112942.1 BC113656.1 
    BC143716.1 CR749832.1 

    12 DOTS entries:

    DT.441446  DT.100777335  DT.91750028  DT.100777333  DT.121485529  DT.422400  DT.100655985  DT.121485560 
    DT.91734891  DT.91862825  DT.92022435  DT.95367627 

    Selected AceView cDNA sequences (see all 170):

    AW512894 AI133393 AW151919 AY598335 CB161159 AA897632 N50322 AW512901 
    AK097133 BM014842 NM_014109 CB120155 CD244182 CD359169 BX643073 AI458836 
    AA287933 BI861220 BE672344 BC019909 AA995158 BG292361 AW168205 CB159561 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ATAD2 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c · 16d ^ 17a ·
    SP1:                          -                                                                                                                                 
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 17b · 17c ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21a · 21b · 21c ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25
    SP1:                                                                                                
    SP2:                                                                                                
    SP3:                                                                                                
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for ATAD2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ATAD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTGCGGGA
    ATAD2 Expression
    About this image


    ATAD2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Mesencephalic Ventricular Zone
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             XX Germ Cells Ovigerous Cord
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Gonad
             XX Germ Cells Ovigerous Cord
    ATAD2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ATAD2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.370834

    UniProtKB/Swiss-Prot: ATAD2_HUMAN, Q6PL18
    Tissue specificity: Highly expressed in estrogen receptor positive breast tumors and in osteosarcoma tumors

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    QuantiFast Probe-based Assays in human, mouse, rat ATAD2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATAD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ATAD2 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atad21 , 5 ATPase family, AAA domain containing 21, 5 85.27(n)1
    84.68(a)1
      15 (24.32 cM)5
    704721  NM_027435.21  NP_081711.21 
     580940475 
    chicken
    (Gallus gallus)
    Aves ATAD21 ATPase family, AAA domain containing 2 66.64(n)
    62.74(a)
      420346  XM_418453.4  XP_418453.4 
    lizard
    (Anolis carolinensis)
    Reptilia ATAD26
    ATPase family, AAA domain containing 2
    62(a)
    1 ↔ 1
    4(6795919-6828489)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.256752 Xenopus laevis transcribed sequence with moderate similarity more 75.69(n)    BU901193.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wu:fi16e041 wu:fi16e04 60.11(n)
    59.91(a)
      327543  XM_003200248.2  XP_003200296.2 
    worm
    (Caenorhabditis elegans)
    Secernentea lex-16
    Protein LEX-1, isoform a (lex-1) mRNA, complete cd...
    31(a)
    1 → many
    IV(12079473-12084360) WBGene00008682
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YTA7(YGR270W)4 Protein that localizes to chromatin and has a role more   --   7(1027370-1031509) 853186  NP_011786.1 
    rice
    (Oryza sativa)
    Liliopsida Os.88862 Oryza sativa (japonica cultivar-group) cDNA clone0 more 71.36(n)    AK099978.1 


    ENSEMBL Gene Tree for ATAD2 (if available)
    TreeFam Gene Tree for ATAD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ATAD2 gene
    ATAD2B2  
    6 SIMAP similar genes for ATAD2 using alignment to 3 protein entries:     ATAD2_HUMAN (see all proteins):
    PSMC1    PSMC5    PSMC2    PSMC6    ATAD2B    PSMC3

    ATAD2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ATAD2 (see all 1499)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1462409831,2
    --124331891(+) AGACAA/TAACAC 1 -- ds50010--------
    rs1155485691,2
    C,F--124331959(+) ATGTAC/GCATAT 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1928145261,2
    --124332214(+) TGTATC/TTCCAG 1 -- ut310--------
    rs1392630171,2
    --124332254(+) GACTGA/GCATTG 1 -- ut310--------
    rs1855281081,2
    --124332451(+) AGCTAC/TTTCAC 1 -- ut310--------
    rs1123086231,2
    C,F--124332475(+) GAATGT/ACTTCT 1 -- ut312Minor allele frequency- A:0.05CSA WA 120
    rs1176983291,2
    C,F--124332556(+) CCATTA/CATATA 1 -- ut311Minor allele frequency- C:0.01NA 120
    rs40065091,2
    H--124332701(-) TGTGTT/AAATAA 1 -- ut314Minor allele frequency- A:0.00NS EA 418
    rs781467421,2
    F--124332710(+) CATTTA/GTTGTG 1 -- ut310--------
    rs1121891991,2
    C,F--124332742(+) CAAGAA/TATATT 1 -- ut312Minor allele frequency- T:0.04CSA WA 120

    HapMap Linkage Disequilibrium report for ATAD2 (124332090 - 124428590 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ATAD2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv891428CNV Loss21882294
    nsv831449CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing ATAD2:
    Ovarian Cancer
    SeqTarget long-range PCR primers for resequencing ATAD2
    DNA2.0 Custom Variant and Variant Library Synthesis for ATAD2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611941    OMIM disorders: --

    15 diseases for ATAD2:    
    About MalaCards
    anogenital venereal wart    genital herpes    gonorrhea    human immunodeficiency virus infectious disease
    intrahepatic cholangiocarcinoma    cholangiocarcinoma    osteosarcoma    lung adenocarcinoma
    tonsillitis    tuberculosis    lung cancer    prostatitis
    prostate cancer    breast cancer    adenocarcinoma

    3 diseases from the University of Copenhagen DISEASES database for ATAD2:
    Human immunodeficiency virus infectious disease     Genital herpes     Gonorrhea

    ATAD2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    Export disorders for ATAD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ATAD2 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with ATAD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ANCCA, an estrogen-regulated AAA+ ATPase coactivator for ERalpha, is required for coregulator occupancy and chromatin modification. (PubMed id 17998543)1, 2 Zou J.X.... Chen H.-W. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PubMed id 15334068)1, 2 Petroziello J.... Carter P. (Oncogene 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. Integrated genomic analysis of the 8q24 amplification in endometrial cancers identifies ATAD2 as essential to MYC-dependent cancers. (PubMed id 23393560)1 Raeder M.B....Salvesen H.B. (PLoS ONE 2013)
    8. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)
    9. Direct cooperation between androgen receptor and E2F1 reveals a common regulation mechanism for androgen-responsive genes in prostate cells. (PubMed id 22771493)1 Altintas D.M....Samarut J. (Mol. Endocrinol. 2012)
    10. Histone recognition and large-scale structural analysis of the human bromodomain family. (PubMed id 22464331)2 Filippakopoulos P.... Knapp S. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29028 HGNC: 30123 AceView: ATAD2 Ensembl:ENSG00000156802 euGenes: HUgn29028
    ECgene: ATAD2 H-InvDB: ATAD2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ATAD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ATAD2 gene:
    Search GeneIP for patents involving ATAD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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