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Aliases for ATAD2 Gene

Aliases for ATAD2 Gene

  • ATPase Family, AAA Domain Containing 2 2 3
  • ANCCA 3 4 6
  • AAA Nuclear Coregulator Cancer-Associated Protein 3 4
  • ATPase Family AAA Domain-Containing Protein 2 3
  • EC 3.6.1.3 4
  • PRO2000 3
  • CT137 3

External Ids for ATAD2 Gene

Summaries for ATAD2 Gene

Entrez Gene Summary for ATAD2 Gene

  • A large family of ATPases has been described, whose key feature is that they share a conserved region of about 220 amino acids that contains an ATP-binding site. The proteins that belong to this family either contain one or two AAA (ATPases Associated with diverse cellular Activities) domains. AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. The protein encoded by this gene contains two AAA domains, as well as a bromodomain. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATAD2 Gene

ATAD2 (ATPase Family, AAA Domain Containing 2) is a Protein Coding gene. Diseases associated with ATAD2 include gonorrhea and genital herpes. Among its related pathways are Gastric cancer network 2. GO annotations related to this gene include ATPase activity. An important paralog of this gene is ATAD2B.

UniProtKB/Swiss-Prot for ATAD2 Gene

  • May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATAD2 Gene

Genomics for ATAD2 Gene

Genomic Location for ATAD2 Gene

Start:
123,319,850 bp from pter
End:
123,416,350 bp from pter
Size:
96,501 bases
Orientation:
Minus strand

Genomic View for ATAD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATAD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATAD2 Gene

Regulatory Elements for ATAD2 Gene

Proteins for ATAD2 Gene

  • Protein details for ATAD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PL18-ATAD2_HUMAN
    Recommended name:
    ATPase family AAA domain-containing protein 2
    Protein Accession:
    Q6PL18
    Secondary Accessions:
    • Q14CR1
    • Q658P2
    • Q68CQ0
    • Q6PJV6
    • Q8N890
    • Q9UHS5

    Protein attributes for ATAD2 Gene

    Size:
    1390 amino acids
    Molecular mass:
    158554 Da
    Quaternary structure:
    • Interacts with ESR1 and NCOA3 and these interactions are enhanced by estradiol. Interacts with acetylated lysine residues on histone H1.4, H2A, H2B and H3 (in vitro).
    SequenceCaution:
    • Sequence=AAF22032.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH10686.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part (676-679).; Evidence={ECO:0000305}; Sequence=AAH19909.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ATAD2 Gene

    Alternative splice isoforms for ATAD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATAD2 Gene

Proteomics data for ATAD2 Gene at MOPED

Post-translational modifications for ATAD2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys175, Lys311, Lys473, Lys489, Lys504, Lys931, and Lys1042

Other Protein References for ATAD2 Gene

No data available for DME Specific Peptides for ATAD2 Gene

Domains for ATAD2 Gene

Gene Families for ATAD2 Gene

HGNC:
  • AATP :ATPases / AAA-type

Suggested Antigen Peptide Sequences for ATAD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PL18

UniProtKB/Swiss-Prot:

ATAD2_HUMAN
Domain:
  • Contains 1 bromo domain.:
    • Q6PL18
Family:
  • Belongs to the AAA ATPase family.:
    • Q6PL18
genes like me logo Genes that share domains with ATAD2: view

Function for ATAD2 Gene

Molecular function for ATAD2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function: May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.
UniProtKB/Swiss-Prot Induction: Up-regulated in breast, uterus, colon, ovary, and stomach tumors. Induced in breast cancer cells overexpressing NCOA3 or treated with estrogen. Down-regulated in 5-fluorouracil-resistant derivatives of the colon cancer cell line HCT 116.

Enzyme Numbers (IUBMB) for ATAD2 Gene

Gene Ontology (GO) - Molecular Function for ATAD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IBA --
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
GO:0016887 ATPase activity IDA 17998543
GO:0042393 histone binding IBA --
genes like me logo Genes that share ontologies with ATAD2: view

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ATAD2 Gene

Localization for ATAD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATAD2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATAD2 Gene COMPARTMENTS Subcellular localization image for ATAD2 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for ATAD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with ATAD2: view

Pathways for ATAD2 Gene

SuperPathways for ATAD2 Gene

Superpath Contained pathways
1 Gastric cancer network 2
genes like me logo Genes that share pathways with ATAD2: view

Pathways by source for ATAD2 Gene

1 BioSystems pathway for ATAD2 Gene

Gene Ontology (GO) - Biological Process for ATAD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006351 transcription, DNA-templated IEA --
GO:0031936 negative regulation of chromatin silencing IBA --
GO:0045893 positive regulation of transcription, DNA-templated IDA 17998543
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with ATAD2: view

Transcripts for ATAD2 Gene

Unigene Clusters for ATAD2 Gene

ATPase family, AAA domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATAD2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c · 16d ^ 17a ·
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

ExUns: 17b · 17c ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21a · 21b · 21c ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -

Relevant External Links for ATAD2 Gene

GeneLoc Exon Structure for
ATAD2
ECgene alternative splicing isoforms for
ATAD2

Expression for ATAD2 Gene

mRNA expression in normal human tissues for ATAD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATAD2 Gene

SOURCE GeneReport for Unigene cluster for ATAD2 Gene Hs.370834

mRNA Expression by UniProt/SwissProt for ATAD2 Gene

Q6PL18-ATAD2_HUMAN
Tissue specificity: Highly expressed in estrogen receptor positive breast tumors and in osteosarcoma tumors.
genes like me logo Genes that share expressions with ATAD2: view

No data available for mRNA differential expression in normal tissues for ATAD2 Gene

Orthologs for ATAD2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATAD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATAD2 35
  • 99.16 (n)
  • 98.63 (a)
ATAD2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATAD2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATAD2 35
  • 91.63 (n)
  • 92.41 (a)
ATAD2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atad2 35
  • 85.27 (n)
  • 84.68 (a)
Atad2 16
Atad2 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATAD2 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATAD2 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atad2 35
  • 86.02 (n)
  • 85.46 (a)
chicken
(Gallus gallus)
Aves ATAD2 35
  • 66.64 (n)
  • 62.74 (a)
ATAD2 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATAD2 36
  • 62 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25675 35
tropical clawed frog
(Silurana tropicalis)
Amphibia atad2 35
  • 67.29 (n)
  • 68.5 (a)
Str.3073 35
zebrafish
(Danio rerio)
Actinopterygii ATAD2 36
  • 54 (a)
OneToOne
wu:fi16e04 35
  • 60.11 (n)
  • 59.91 (a)
worm
(Caenorhabditis elegans)
Secernentea lex-1 36
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YTA7 36
  • 23 (a)
OneToMany
YTA7 38
corn
(Zea mays)
Liliopsida Zm.12719 35
rice
(Oryza sativa)
Liliopsida Os.8886 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToMany
Species with no ortholog for ATAD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATAD2 Gene

ENSEMBL:
Gene Tree for ATAD2 (if available)
TreeFam:
Gene Tree for ATAD2 (if available)

Paralogs for ATAD2 Gene

Paralogs for ATAD2 Gene

Selected SIMAP similar genes for ATAD2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ATAD2: view

Variants for ATAD2 Gene

Sequence variations from dbSNP and Humsavar for ATAD2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs9021 -- 123,320,660(-) TCCCT(C/T)GTCTT utr-variant-3-prime
rs15060 -- 123,320,682(+) GATGG(G/T)AGGAG utr-variant-3-prime
rs900628 -- 123,352,621(-) CTTAC(G/T)GAACC intron-variant
rs900629 -- 123,352,219(-) CTTGC(C/G)GGGGG intron-variant
rs922068 -- 123,391,637(-) TATTT(C/T)TTAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATAD2 Gene

Variant ID Type Subtype PubMed ID
nsv831449 CNV Loss 17160897
nsv891428 CNV Loss 21882294

Relevant External Links for ATAD2 Gene

HapMap Linkage Disequilibrium report
ATAD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATAD2 Gene

Disorders for ATAD2 Gene

(2) MalaCards Diseases for ATAD2 Gene

Search for ATAD2 Gene in MalaCards »

(3) University of Copenhagen DISEASES for ATAD2 Gene

genes like me logo Genes that share disorders with ATAD2: view

No data available for UniProtKB/Swiss-Prot for ATAD2 Gene

Publications for ATAD2 Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  2. ANCCA, an estrogen-regulated AAA+ ATPase coactivator for ERalpha, is required for coregulator occupancy and chromatin modification. (PMID: 17998543) Zou J.X. … Chen H.-W. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PMID: 15334068) Petroziello J. … Carter P. (Oncogene 2004) 3 4

Products for ATAD2 Gene

Sources for ATAD2 Gene

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