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ATAD1 Gene

protein-coding   GIFtS: 55
GCID: GC10M089502

ATPase Family, AAA Domain Containing 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ATPase Family, AAA Domain Containing 11 2
THORASE2 5
AFDC12
ATPase Family AAA Domain-Containing Protein 12
EC 3.6.1.33
Thorase3

External Ids:    HGNC: 259031   Entrez Gene: 848962   Ensembl: ENSG000001381387   OMIM: 6144525   UniProtKB: Q8NBU53   

Export aliases for ATAD1 gene to outside databases

Previous GC identifers: GC10M089178 GC10M083148


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ATAD1 Gene:
ATAD1 (ATPase family, AAA domain containing 1) is a protein-coding gene. Diseases associated with ATAD1 include breast and colorectal cancer, and alzheimer's disease. GO annotations related to this gene include ATPase activity.

UniProtKB/Swiss-Prot: ATAD1_HUMAN, Q8NBU5
Function: ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR),
thereby regulating synaptic plasticity and learning and memory. Required for NMDA-stimulated AMPAR
internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are
ATPase-dependent (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ATAD1 gene promoter:
         MyoD   CUTL1   HNF-1A   C/EBPalpha   MEF-2A   HNF-1   FOXJ2 (long isoform)   FOXJ2   aMEF-2   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATAD1 promoter sequence
   Search Chromatin IP Primers for ATAD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATAD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.31   Ensembl cytogenetic band:  10q23.31   HGNC cytogenetic band: 10q23.31

ATAD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATAD1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M089502:  view genomic region     (about GC identifiers)

Start:
89,511,269 bp from pter      End:
89,601,100 bp from pter
Size:
89,832 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ATAD1_HUMAN, Q8NBU5 (See protein sequence)
Recommended Name: ATPase family AAA domain-containing protein 1  
Size: 361 amino acids; 40744 Da
Subunit: Interacts with GRIA2 and GRIP1 in an ATP-dependent manner. ATAD1-catalyzed ATP hydrolysis disrupts not
only its binding to GRIA2 and GRIP1, but also interaction between GRIP1 and GRIA2, leading to AMPAR complex
disassembly (By similarity)
Secondary accessions: D3DR26 Q6DKG1 Q6P4B9 Q8N3G1 Q8WYR9 Q969Y3
Alternative splicing: 2 isoforms:  Q8NBU5-1   Q8NBU5-2   

Explore the universe of human proteins at neXtProt for ATAD1: NX_Q8NBU5

Explore proteomics data for ATAD1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys46, Lys263, Lys274
  • Modification sites at PhosphoSitePlus

  • See ATAD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_116199.2  
    ENSEMBL proteins: 
     ENSP00000339017   ENSP00000339016   ENSP00000412968   ENSP00000445500  

    ATAD1 Human Recombinant Protein Products:

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    Novus Biologicals ATAD1 Protein
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for ATAD1

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    Abcam antibodies for ATAD1
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    LSBio Antibodies in human, mouse, rat for ATAD1

    ATAD1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. CLIAs for ATAD1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    AATP: ATPases / AAA-type

    4 InterPro protein domains:
     IPR003959 ATPase_AAA_core
     IPR003960 ATPase_AAA_CS
     IPR027417 P-loop_NTPase
     IPR003593 AAA+_ATPase

    Graphical View of Domain Structure for InterPro Entry Q8NBU5

    ProtoNet protein and cluster: Q8NBU5

    1 Blocks protein domain: IPB003960 AAA-protein subdomain

    UniProtKB/Swiss-Prot: ATAD1_HUMAN, Q8NBU5
    Similarity: Belongs to the AAA ATPase family


    ATAD1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATAD1_HUMAN, Q8NBU5
    Function: ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR),
    thereby regulating synaptic plasticity and learning and memory. Required for NMDA-stimulated AMPAR
    internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are
    ATPase-dependent (By similarity)
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Number (IUBMB): EC 3.6.1.31

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
    GO:0009378four-way junction helicase activity ----
    GO:0016301kinase activity ----
         
    ATAD1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ATAD1:
     Increased G1 DNA content 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Atad1):
     behavior/neurological  growth/size/body  mortality/aging  nervous system 

    ATAD1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ATAD1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ATAD1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ATAD1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ATAD1

    miRNA
    Products:
        
    miRTarBase miRNAs that target ATAD1:
    hsa-mir-1260b (MIRT052731), hsa-mir-215-5p (MIRT024433), hsa-mir-192-5p (MIRT026753), hsa-mir-146b-5p (MIRT041617)

    Block miRNA regulation of human, mouse, rat ATAD1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ATAD1 (see all 23):
    hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-496 hsa-miR-3129-5p hsa-miR-139-5p hsa-miR-340 hsa-miR-3133 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidATAD1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ATAD1
    Predesigned siRNA for gene silencing in human, mouse, rat ATAD1

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for ATAD1 (see all 7)
    OriGene ORF clones in mouse, rat for ATAD1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ATAD1 (NM_021167)
    Sino Biological Human cDNA Clone for ATAD1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATAD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATAD1

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATAD1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ATAD1_HUMAN, Q8NBU5: Peroxisome (By similarity). Cell junction, synapse, postsynaptic cell membrane (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    peroxisome5
    cytosol3
    plasma membrane3
    mitochondrion2
    endoplasmic reticulum1
    extracellular1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0005778peroxisomal membrane IDA--
    GO:0030054cell junction IEA--
    GO:0045211postsynaptic membrane ISS--

    ATAD1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ATAD1
    Interactions:

        Search GeneGlobe Interaction Network for ATAD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ATAD1 (Q8NBU53 ENSP000003390164) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BABAM1Q9NWV83, ENSP000003524084I2D: score=2 STRING: ENSP00000352408
    TADA2AO754783, ENSP000002253964I2D: score=1 STRING: ENSP00000225396
    USP19O949663, ENSP000003818634I2D: score=2 STRING: ENSP00000381863
    TRRAPQ9Y4A53, ENSP000003477334I2D: score=1 STRING: ENSP00000347733
    ASNA1O436813, ENSP000003498874I2D: score=2 STRING: ENSP00000349887
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002092positive regulation of receptor internalization ISS--
    GO:0006200ATP catabolic process ----
    GO:0006281DNA repair ----
    GO:0006310DNA recombination ----
    GO:0007612learning ISS--

    ATAD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ATAD1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ATAD1 gene: 
    NM_032810.2  

    Unigene Cluster for ATAD1:

    ATPase family, AAA domain containing 1
    Hs.435948  [show with all ESTs]
    Unigene Representative Sequence: NM_032810
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000308448(uc001kez.1) ENST00000328142(uc010qmr.1 uc009xth.1 uc001key.1)
    ENST00000495903 ENST00000400215 ENST00000541004
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ATAD1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ATAD1 (see all 23):
    hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-496 hsa-miR-3129-5p hsa-miR-139-5p hsa-miR-340 hsa-miR-3133 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidATAD1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ATAD1
    Predesigned siRNA for gene silencing in human, mouse, rat ATAD1
    Clone
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    OriGene clones in human, mouse for ATAD1 (see all 7)
    OriGene ORF clones in mouse, rat for ATAD1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ATAD1 (NM_021167)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATAD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATAD1
    Primer
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    OriGene qPCR primer pairs and template standards for ATAD1
    OriGene qSTAR qPCR primer pairs in human, mouse for ATAD1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ATAD1
      QuantiTect SYBR Green Assays in human, mouse, rat ATAD1
      QuantiFast Probe-based Assays in human, mouse, rat ATAD1

    Additional mRNA sequence: 

    AF361493.1 AK027506.1 AK075223.1 AK304297.1 AL834370.1 BC010868.1 BC063530.1 BC073998.1 

    14 DOTS entries:

    DT.447965  DT.99965258  DT.95271271  DT.100786150  DT.92431407  DT.100786154  DT.92431404  DT.92431405 
    DT.95336328  DT.100786158  DT.121254280  DT.121254334  DT.95327999  DT.100671692 

    Selected AceView cDNA sequences (see all 275):

    AW664415 AA749063 AK027506 AA319692 AI418914 BF941440 BQ694273 BM984201 
    BC010868 AA757577 BC063530 BU689767 AA280617 AW590234 BQ000331 BX333390 
    AI184905 AL711860 W32476 AA369840 AK075223 AA304993 AA770430 AI470700 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ATAD1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:              -                                                                           
    SP2:                                                                          -               
    SP3:                                                                                          
    SP4:                                                                                          


    ECgene alternative splicing isoforms for ATAD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ATAD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGAAAACGG
    ATAD1 Expression
    About this image

    ATAD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ATAD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.435948
        Custom PCR Arrays for ATAD1
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    QuantiFast Probe-based Assays in human, mouse, rat ATAD1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATAD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ATAD1 gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atad11 , 5 ATPase family, AAA domain containing 11, 5 92.15(n)1
    100(a)1
      19 (27.55 cM)5
    679791  NM_026487.31  NP_080763.21 
     326725635 
    chicken
    (Gallus gallus)
    Aves ATAD11 ATPase family, AAA domain containing 1 83.1(n)
    93.63(a)
      423676  XM_004941993.1  XP_004942050.1 
    lizard
    (Anolis carolinensis)
    Reptilia ATAD16
    ATPase family, AAA domain containing 1
    92(a)
    1 ↔ 1
    GL343246.1(1024122-1045771)
    African clawed frog
    (Xenopus laevis)
    Amphibia BG407830.12   -- 78.4(n)    BG407830.1 
    zebrafish
    (Danio rerio)
    Actinopterygii atad1b1 ATPase family, AAA domain containing 1b 74.14(n)
    82.91(a)
      368412  NM_001024421.2  NP_001019592.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta nmd1 no mitochondrial derivative 57.74(n)
    57.14(a)
      44021  NM_135529.2  NP_609373.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mspn-16
    Protein MSPN-1, isoform a (mspn-1) mRNA, complete ...
    50(a)
    1 ↔ 1
    IV(10177968-10180307) WBGene00010557
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MSP1(YGR028W)4
    MSP11
    Mitochondrial protein involved in sorting of proteins more4
    MSP11
    53.74(n)1
    48.4(a)1
      7(542203-543291)4
    8529151, 4  NP_011542.31  NP_011542.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G276801 AT4G27680 53.33(n)
    45.08(a)
      828882  NM_118907.3  NP_194498.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g07145001 Os06g0714500 49.19(n)
    46.28(a)
      4342062  NM_001065110.1  NP_001058575.1 


    ENSEMBL Gene Tree for ATAD1 (if available)
    TreeFam Gene Tree for ATAD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ATAD1 gene
    12 SIMAP similar genes for ATAD1 using alignment to 2 protein entries:     ATAD1_HUMAN (see all proteins):
    VPS4B    SPATA5    DKFZp667C165    KATNA1    FIGN    PSMC6
    NVL    ATAD2B    DKFZp434K0126    VCP    KATNAL2    PSMC3

    ATAD1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ATAD1
    PGOHUM00000234837


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ATAD1 (see all 1140)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0359034
    A colorectal cancer sample4--see VAR_0359032 V I mis40--------
    rs1174834221,2
    F--89512543(+) GATTAG/CTATAC 1 -- ds50011Minor allele frequency- C:0.01NA 120
    rs569390551,2
    F--89512818(+) AAAAAT/CCCCAG 1 -- ds50011Minor allele frequency- C:0.03WA 118
    rs1887843481,2
    --89512838(+) AATTAC/TTGAAA 1 -- ds50010--------
    rs122531131,2
    C,F,A,H--89512839(+) ATTACT/CGAAAA 1 -- ds500124Minor allele frequency- C:0.28NA NS EA WA CSA 2486
    rs558976491,2
    C--89512925(+) GTTATC/TAAAAA 1 -- ut310--------
    rs112025371,2
    C--89513069(+) ATAAAA/C/TGATCT 2 -- ut310--------
    rs74811,2
    C,F,A,H--89513118(-) TGTGTC/TACTGG 1 -- ut31 ese318Minor allele frequency- T:0.26MN NS EA NA WA 2312
    rs115466811,2
    C--89513122(+) TGACAC/GATGAA 1 -- ut31 ese32Minor allele frequency- G:0.00NA 4
    rs1476448641,2
    --89513309(+) ATTCAC/TATTAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ATAD1 (89511269 - 89601100 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ATAD1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1509111CNV Deletion17803354
    esv2254676CNV Deletion18987734
    esv2739284CNV Deletion23290073
    esv2739295CNV Deletion23290073
    nsv518233CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614452    OMIM disorders: --

    4 diseases for ATAD1:    
    About MalaCards
    breast and colorectal cancer    alzheimer's disease    malaria    colorectal cancer


    ATAD1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ATAD1
    Human Genome Epidemiology (HuGE) Navigator: ATAD1 (3 documents)

    Export disorders for ATAD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ATAD1 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with ATAD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells. (PubMed id 17203973)1, 2 Vasilescu J.... Figeys D. (J. Proteome Res. 2007)
    4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84896 HGNC: 25903 AceView: ATAD1 Ensembl:ENSG00000138138 euGenes: HUgn84896
    ECgene: ATAD1 H-InvDB: ATAD1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ATAD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ATAD1 gene:
    Search GeneIP for patents involving ATAD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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