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Aliases for ATAD1 Gene

Aliases for ATAD1 Gene

  • ATPase Family, AAA Domain Containing 1 2 3 5
  • THORASE 3 4
  • EC 3.6.1.3 4
  • FNP001 3
  • AFDC1 3

External Ids for ATAD1 Gene

Previous GeneCards Identifiers for ATAD1 Gene

  • GC10M089178
  • GC10M089502
  • GC10M083148

Summaries for ATAD1 Gene

GeneCards Summary for ATAD1 Gene

ATAD1 (ATPase Family, AAA Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include ATPase activity and microtubule-severing ATPase activity.

UniProtKB/Swiss-Prot for ATAD1 Gene

  • ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory. Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATAD1 Gene

Genomics for ATAD1 Gene

Regulatory Elements for ATAD1 Gene

Genomic Location for ATAD1 Gene

Chromosome:
10
Start:
87,751,512 bp from pter
End:
87,841,349 bp from pter
Size:
89,838 bases
Orientation:
Minus strand

Genomic View for ATAD1 Gene

Genes around ATAD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATAD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATAD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATAD1 Gene

Proteins for ATAD1 Gene

  • Protein details for ATAD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBU5-ATAD1_HUMAN
    Recommended name:
    ATPase family AAA domain-containing protein 1
    Protein Accession:
    Q8NBU5
    Secondary Accessions:
    • D3DR26
    • Q6DKG1
    • Q6P4B9
    • Q8N3G1
    • Q8WYR9
    • Q969Y3

    Protein attributes for ATAD1 Gene

    Size:
    361 amino acids
    Molecular mass:
    40744 Da
    Quaternary structure:
    • Interacts with GRIA2 and GRIP1 in an ATP-dependent manner. ATAD1-catalyzed ATP hydrolysis disrupts not only its binding to GRIA2 and GRIP1, but also interaction between GRIP1 and GRIA2, leading to AMPAR complex disassembly (By similarity).

    Alternative splice isoforms for ATAD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATAD1 Gene

Proteomics data for ATAD1 Gene at MOPED

Post-translational modifications for ATAD1 Gene

  • Ubiquitination at Lys 46, Lys 263, and Lys 274
  • Modification sites at PhosphoSitePlus

Other Protein References for ATAD1 Gene

Antibody Products

No data available for DME Specific Peptides for ATAD1 Gene

Domains & Families for ATAD1 Gene

Gene Families for ATAD1 Gene

Protein Domains for ATAD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NBU5

UniProtKB/Swiss-Prot:

ATAD1_HUMAN :
  • Belongs to the AAA ATPase family.
Family:
  • Belongs to the AAA ATPase family.
genes like me logo Genes that share domains with ATAD1: view

Function for ATAD1 Gene

Molecular function for ATAD1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory. Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity).

Enzyme Numbers (IUBMB) for ATAD1 Gene

genes like me logo Genes that share phenotypes with ATAD1: view

Animal Models for ATAD1 Gene

MGI Knock Outs for ATAD1:

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ATAD1 Gene

Localization for ATAD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATAD1 Gene

Peroxisome. Cell junction, synapse, postsynaptic cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATAD1 Gene COMPARTMENTS Subcellular localization image for ATAD1 gene
Compartment Confidence
peroxisome 5
plasma membrane 5
cytosol 3
mitochondrion 3
nucleus 2
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for ATAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045211 postsynaptic membrane ISS --
genes like me logo Genes that share ontologies with ATAD1: view

Pathways & Interactions for ATAD1 Gene

SuperPathways for ATAD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ATAD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ATAD1 Gene

Drugs & Compounds for ATAD1 Gene

(1) Drugs for ATAD1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for ATAD1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with ATAD1: view

Transcripts for ATAD1 Gene

Unigene Clusters for ATAD1 Gene

ATPase family, AAA domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATAD1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2: -
SP3:
SP4:

Relevant External Links for ATAD1 Gene

GeneLoc Exon Structure for
ATAD1
ECgene alternative splicing isoforms for
ATAD1

Expression for ATAD1 Gene

mRNA expression in normal human tissues for ATAD1 Gene

Protein differential expression in normal tissues from HIPED for ATAD1 Gene

This gene is overexpressed in Nasal epithelium (24.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATAD1 Gene



SOURCE GeneReport for Unigene cluster for ATAD1 Gene Hs.435948

genes like me logo Genes that share expression patterns with ATAD1: view

Protein tissue co-expression partners for ATAD1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ATAD1 Gene

Orthologs for ATAD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATAD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ATAD1 35
  • 95.11 (n)
  • 99.72 (a)
ATAD1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATAD1 35
  • 93.81 (n)
  • 100 (a)
ATAD1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atad1 35
  • 92.15 (n)
  • 100 (a)
Atad1 16
Atad1 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ATAD1 35
  • 100 (n)
  • 100 (a)
ATAD1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atad1 35
  • 91.87 (n)
  • 99.72 (a)
oppossum
(Monodelphis domestica)
Mammalia ATAD1 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATAD1 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATAD1 35
  • 83.1 (n)
  • 93.63 (a)
ATAD1 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATAD1 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atad1 35
  • 76.48 (n)
  • 88.61 (a)
zebrafish
(Danio rerio)
Actinopterygii atad1b 35
  • 74.14 (n)
  • 82.91 (a)
atad1b 36
  • 82 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009625 35
  • 57.54 (n)
  • 60.4 (a)
fruit fly
(Drosophila melanogaster)
Insecta nmd 35
  • 57.74 (n)
  • 57.14 (a)
CG4701 36
  • 47 (a)
OneToMany
nmd 36
  • 52 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mspn-1 36
  • 50 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR036W 35
  • 51.15 (n)
  • 51.03 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B06094g 35
  • 56.45 (n)
  • 52.55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MSP1 35
  • 53.74 (n)
  • 48.4 (a)
MSP1 36
  • 43 (a)
OneToOne
MSP1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G27680 35
  • 53.33 (n)
  • 45.08 (a)
rice
(Oryza sativa)
Liliopsida Os06g0714500 35
  • 49.19 (n)
  • 46.28 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07988 35
  • 54.3 (n)
  • 51.17 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC24B10.10c 35
  • 52.1 (n)
  • 45.36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11054 36
  • 48 (a)
OneToOne
Species with no ortholog for ATAD1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATAD1 Gene

ENSEMBL:
Gene Tree for ATAD1 (if available)
TreeFam:
Gene Tree for ATAD1 (if available)

Paralogs for ATAD1 Gene

(12) SIMAP similar genes for ATAD1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ATAD1 Gene

genes like me logo Genes that share paralogs with ATAD1: view

No data available for Paralogs for ATAD1 Gene

Variants for ATAD1 Gene

Sequence variations from dbSNP and Humsavar for ATAD1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_035903 A colorectal cancer sample
rs7480 -- 87,753,695(-) AACAA(A/G)TAGCT nc-transcript-variant, utr-variant-3-prime
rs7481 -- 87,753,361(-) TGTGT(C/T)ACTGG nc-transcript-variant, utr-variant-3-prime
rs959667 -- 87,756,572(-) AAGGA(A/G)AAAAA intron-variant
rs1114105 -- 87,802,680(-) agcaa(A/G)aataa intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ATAD1 Gene

Variant ID Type Subtype PubMed ID
nsv518233 CNV Loss 19592680
esv2254676 CNV Deletion 18987734
esv2739284 CNV Deletion 23290073
esv2739295 CNV Deletion 23290073
esv1509111 CNV Deletion 17803354

Variation tolerance for ATAD1 Gene

Residual Variation Intolerance Score: 28.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATAD1 Gene

HapMap Linkage Disequilibrium report
ATAD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATAD1 Gene

Disorders for ATAD1 Gene

Relevant External Links for ATAD1

Genetic Association Database (GAD)
ATAD1
Human Genome Epidemiology (HuGE) Navigator
ATAD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATAD1

No disorders were found for ATAD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATAD1 Gene

Publications for ATAD1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress. (PMID: 24797263) Tong J. … Moran M.F. (Mol. Cell Proteomics 2014) 3
  5. Msp1/ATAD1 maintains mitochondrial function by facilitating the degradation of mislocalized tail-anchored proteins. (PMID: 24843043) Chen Y.C. … Rutter J. (EMBO J. 2014) 3

Products for ATAD1 Gene

Sources for ATAD1 Gene

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