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Aliases for ATAD1 Gene

Aliases for ATAD1 Gene

  • ATPase Family, AAA Domain Containing 1 2 3
  • THORASE 3 4 6
  • ATPase Family AAA Domain-Containing Protein 1 3
  • EC 3.6.1.3 4
  • FNP001 3
  • AFDC1 3

External Ids for ATAD1 Gene

Summaries for ATAD1 Gene

GeneCards Summary for ATAD1 Gene

ATAD1 (ATPase Family, AAA Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include ATPase activity.

UniProtKB/Swiss-Prot for ATAD1 Gene

  • ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory. Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATAD1 Gene

Genomics for ATAD1 Gene

Genomic Location for ATAD1 Gene

Start:
87,751,512 bp from pter
End:
87,841,351 bp from pter
Size:
89,840 bases
Orientation:
Minus strand

Genomic View for ATAD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATAD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATAD1 Gene

Regulatory Elements for ATAD1 Gene

Proteins for ATAD1 Gene

  • Protein details for ATAD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBU5-ATAD1_HUMAN
    Recommended name:
    ATPase family AAA domain-containing protein 1
    Protein Accession:
    Q8NBU5
    Secondary Accessions:
    • D3DR26
    • Q6DKG1
    • Q6P4B9
    • Q8N3G1
    • Q8WYR9
    • Q969Y3

    Protein attributes for ATAD1 Gene

    Size:
    361 amino acids
    Molecular mass:
    40744 Da
    Quaternary structure:
    • Interacts with GRIA2 and GRIP1 in an ATP-dependent manner. ATAD1-catalyzed ATP hydrolysis disrupts not only its binding to GRIA2 and GRIP1, but also interaction between GRIP1 and GRIA2, leading to AMPAR complex disassembly (By similarity).

    Alternative splice isoforms for ATAD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATAD1 Gene

Proteomics data for ATAD1 Gene at MOPED

Post-translational modifications for ATAD1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys46, Lys263, and Lys274

Other Protein References for ATAD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ATAD1 Gene

Domains for ATAD1 Gene

Gene Families for ATAD1 Gene

HGNC:
  • AATP :ATPases / AAA-type

Protein Domains for ATAD1 Gene

UniProtKB/Swiss-Prot:

ATAD1_HUMAN
Family:
  • Belongs to the AAA ATPase family.:
    • Q8NBU5
genes like me logo Genes that share domains with ATAD1: view

Function for ATAD1 Gene

Molecular function for ATAD1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function: ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory. Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity).

Enzyme Numbers (IUBMB) for ATAD1 Gene

Gene Ontology (GO) - Molecular Function for ATAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
GO:0008568 microtubule-severing ATPase activity IBA --
GO:0009378 four-way junction helicase activity --
GO:0016887 ATPase activity ISS --
genes like me logo Genes that share ontologies with ATAD1: view

Phenotypes for ATAD1 Gene

genes like me logo Genes that share phenotypes with ATAD1: view

miRNA for ATAD1 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ATAD1 Gene

Localization for ATAD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATAD1 Gene

Peroxisome. Cell junction, synapse, postsynaptic cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATAD1 Gene COMPARTMENTS Subcellular localization image for ATAD1 gene
Compartment Confidence
peroxisome 5
cytosol 3
plasma membrane 3
mitochondrion 2
endoplasmic reticulum 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ATAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005739 mitochondrion IEA --
GO:0005778 peroxisomal membrane IDA 21525035
GO:0016020 membrane IDA 19946888
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with ATAD1: view

Pathways for ATAD1 Gene

SuperPathways for ATAD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ATAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002092 positive regulation of receptor internalization ISS --
GO:0006200 obsolete ATP catabolic process --
GO:0006281 DNA repair --
GO:0006310 DNA recombination --
GO:0007612 learning ISS --
genes like me logo Genes that share ontologies with ATAD1: view

No data available for Pathways by source for ATAD1 Gene

Transcripts for ATAD1 Gene

Unigene Clusters for ATAD1 Gene

ATPase family, AAA domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATAD1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2: -
SP3:
SP4:

Relevant External Links for ATAD1 Gene

GeneLoc Exon Structure for
ATAD1
ECgene alternative splicing isoforms for
ATAD1

Expression for ATAD1 Gene

mRNA expression in normal human tissues for ATAD1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATAD1 Gene

SOURCE GeneReport for Unigene cluster for ATAD1 Gene Hs.435948

genes like me logo Genes that share expressions with ATAD1: view

Orthologs for ATAD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATAD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATAD1 36
  • 100 (n)
  • 100 (a)
ATAD1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATAD1 36
  • 95.11 (n)
  • 99.72 (a)
ATAD1 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATAD1 36
  • 93.81 (n)
  • 100 (a)
ATAD1 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atad1 36
  • 92.15 (n)
  • 100 (a)
Atad1 16
Atad1 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATAD1 37
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATAD1 37
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atad1 36
  • 91.87 (n)
  • 99.72 (a)
chicken
(Gallus gallus)
Aves ATAD1 36
  • 83.1 (n)
  • 93.63 (a)
ATAD1 37
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATAD1 37
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atad1 36
  • 76.48 (n)
  • 88.61 (a)
zebrafish
(Danio rerio)
Actinopterygii atad1b 36
  • 74.14 (n)
  • 82.91 (a)
atad1b 37
  • 82 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009625 36
  • 57.54 (n)
  • 60.4 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4701 37
  • 47 (a)
OneToMany
nmd 36
  • 57.74 (n)
  • 57.14 (a)
nmd 37
  • 52 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mspn-1 37
  • 50 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR036W 36
  • 51.15 (n)
  • 51.03 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MSP1 36
  • 53.74 (n)
  • 48.4 (a)
MSP1 37
  • 43 (a)
OneToOne
MSP1 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B06094g 36
  • 56.45 (n)
  • 52.55 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G27680 36
  • 53.33 (n)
  • 45.08 (a)
rice
(Oryza sativa)
Liliopsida Os06g0714500 36
  • 49.19 (n)
  • 46.28 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07988 36
  • 54.3 (n)
  • 51.17 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC24B10.10c 36
  • 52.1 (n)
  • 45.36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11054 37
  • 48 (a)
OneToOne
Species with no ortholog for ATAD1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATAD1 Gene

ENSEMBL:
Gene Tree for ATAD1 (if available)
TreeFam:
Gene Tree for ATAD1 (if available)

Paralogs for ATAD1 Gene

Selected SIMAP similar genes for ATAD1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ATAD1 Gene

genes like me logo Genes that share paralogs with ATAD1: view

No data available for Paralogs for ATAD1 Gene

Variants for ATAD1 Gene

Sequence variations from dbSNP and Humsavar for ATAD1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs7480 -- 87,753,695(-) AACAA(A/G)TAGCT utr-variant-3-prime
rs7481 -- 87,753,361(-) TGTGT(C/T)ACTGG utr-variant-3-prime
rs959667 -- 87,756,572(-) AAGGA(A/G)AAAAA intron-variant
rs1114105 -- 87,802,680(-) agcaa(A/G)aataa intron-variant
rs1234248 -- 87,791,148(+) tacag(G/T)gagcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATAD1 Gene

Variant ID Type Subtype PubMed ID
nsv518233 CNV Loss 19592680
esv2254676 CNV Deletion 18987734
esv2739284 CNV Deletion 23290073
esv2739295 CNV Deletion 23290073
esv1509111 CNV Deletion 17803354

Relevant External Links for ATAD1 Gene

HapMap Linkage Disequilibrium report
ATAD1

Disorders for ATAD1 Gene

Relevant External Links for ATAD1

Genetic Association Database (GAD)
ATAD1
Human Genome Epidemiology (HuGE) Navigator
ATAD1
genes like me logo Genes that share disorders with ATAD1: view

No data available for UniProtKB/Swiss-Prot for ATAD1 Gene

Publications for ATAD1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 49

Products for ATAD1 Gene

Sources for ATAD1 Gene

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