Aliases for ASZ1 Gene
External Ids for ASZ1 Gene
Previous HGNC Symbols for ASZ1 Gene
Previous GeneCards Identifiers for ASZ1 Gene
GeneCards Summary for ASZ1 Gene
ASZ1 (Ankyrin Repeat, SAM And Basic Leucine Zipper Domain Containing 1) is a Protein Coding gene. Diseases associated with ASZ1 include Hepatitis E. Among its related pathways are Gene Expression and Formation of the HIV-1 Early Elongation Complex. GO annotations related to this gene include signal transducer activity. An important paralog of this gene is RNASEL.
UniProtKB/Swiss-Prot for ASZ1 Gene
Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation (By similarity).