Aliases for ASXL3 Gene
External Ids for ASXL3 Gene
Previous HGNC Symbols for ASXL3 Gene
Previous GeneCards Identifiers for ASXL3 Gene
GeneCards Summary for ASXL3 Gene
ASXL3 (Additional Sex Combs Like Transcriptional Regulator 3) is a Protein Coding gene. Diseases associated with ASXL3 include bainbridge-ropers syndrome and severe feeding difficulties - failure to thrive - microcephaly due to asxl3 deficiency. An important paralog of this gene is ASXL2.
UniProtKB/Swiss-Prot for ASXL3 Gene
Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity).