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ASXL2 Gene

protein-coding   GIFtS: 50
GCID: GC02M025960

Additional Sex Combs Like 2 (Drosophila)

Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Additional Sex Combs Like 2 (Drosophila)1 2
Additional Sex Combs-Like Protein 22 3
ASXH22 3
KIAA16853 5
Polycomb Group Protein ASXH22
Putative Polycomb Group Protein ASXL22

External Ids:    HGNC: 238051   Entrez Gene: 552522   Ensembl: ENSG000001439707   OMIM: 6129915   UniProtKB: Q76L833   

Export aliases for ASXL2 gene to outside databases

Previous GC identifers: GC02M025936 GC02M025872 GC02M025815 GC02M025699


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ASXL2 Gene:
ASXL2 is a human homolog of the Drosophila asx gene. Drosophila asx is an enhancer of trithorax (see MIM 159555)
and polycomb (see MIM 610231) (ETP) gene that encodes a chromatin protein with dual functions in transcriptional
activation and silencing (Katoh and Katoh, 2003 (PubMed 12888926)).(supplied by OMIM, Sep 2009)

GeneCards Summary for ASXL2 Gene:
ASXL2 (additional sex combs like 2 (Drosophila)) is a protein-coding gene. Diseases associated with ASXL2 include coloboma, and myelodysplastic syndromes. GO annotations related to this gene include peroxisome proliferator activated receptor binding. An important paralog of this gene is ASXL3.

UniProtKB/Swiss-Prot: ASXL2_HUMAN, Q76L83
Function: Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are
required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG
proteins are not required to initiate repression, but to maintain it during later stages of development. They
probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By
similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as
peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its
adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated
and methylated histone H3




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ASXL2 gene promoter:
         GR   Max1   Egr-3   p53   GR-beta   FOXL1   E47   FOXO1a   GR-alpha   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidASXL2 promoter sequence
   Search Chromatin IP Primers for ASXL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ASXL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p24.1   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p24.1

ASXL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASXL2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M025960:  view genomic region     (about GC identifiers)

Start:
25,956,622 bp from pter      End:
26,101,385 bp from pter
Size:
144,764 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ASXL2_HUMAN, Q76L83 (See protein sequence)
Recommended Name: Putative Polycomb group protein ASXL2  
Size: 1435 amino acids; 153820 Da
Subunit: Interacts with PPARA and PPARG
Sequence caution: Sequence=BAA91889.1; Type=Erroneous initiation; Sequence=BAB21776.2; Type=Erroneous initiation;
Sequence=BAD00088.1; Type=Erroneous initiation;
Secondary accessions: Q53TC9 Q5H9U4 Q76L81 Q86XM1 Q9C0H8 Q9NV67
Alternative splicing: 2 isoforms:  Q76L83-1   Q76L83-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ASXL2: NX_Q76L83

Explore proteomics data for ASXL2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys370
  • Modification sites at PhosphoSitePlus

  • See ASXL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060733.4  
    ENSEMBL proteins: 
     ENSP00000391447   ENSP00000383920   ENSP00000337250   ENSP00000272341  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR024811 ASX/ASX-like
     IPR024817 ASXL2
     IPR028020 ASXH
     IPR007759 DNA-dir_RNA_pol_delta/Asxl
     IPR026905 ASX-like_PHD

    Graphical View of Domain Structure for InterPro Entry Q76L83

    ProtoNet protein and cluster: Q76L83

    UniProtKB/Swiss-Prot: ASXL2_HUMAN, Q76L83
    Domain: Contains two Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, which may be required for an association with nuclear
    receptors (By similarity)
    Similarity: Belongs to the Asx family
    Similarity: Contains 1 PHD-type zinc finger


    ASXL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ASXL2_HUMAN, Q76L83
    Function: Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are
    required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG
    proteins are not required to initiate repression, but to maintain it during later stages of development. They
    probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By
    similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as
    peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its
    adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated
    and methylated histone H3

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0042975peroxisome proliferator activated receptor binding IDA--
    GO:0046872metal ion binding IEA--
         
    ASXL2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ASXL2:
     Decreased Tat-dependent transc 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Asxl2):
     behavior/neurological  cardiovascular system  growth/size/body  mortality/aging  skeleton 

    ASXL2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ASXL2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ASXL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ASXL2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ASXL2

    miRNA
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    miRTarBase miRNAs that target ASXL2:
    hsa-mir-326 (MIRT043632), hsa-mir-15a-5p (MIRT000819), hsa-mir-502-3p (MIRT037979), hsa-mir-221-3p (MIRT046874), hsa-mir-378a-5p (MIRT044010), hsa-mir-16-5p (MIRT000818)

    Block miRNA regulation of human, mouse, rat ASXL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ASXL2 (see all 77):
    hsa-miR-548j hsa-miR-323-3p hsa-miR-549 hsa-miR-520e hsa-miR-300 hsa-miR-519a hsa-miR-890 hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidASXL2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ASXL2
    Predesigned siRNA for gene silencing in human, mouse, rat ASXL2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: ASXL2 (NM_018263)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ASXL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASXL2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASXL2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ASXL2_HUMAN, Q76L83: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ASXL2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including ASXL2: 
              Polycomb & Trithorax Complexes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ASXL2

    Selected Interacting proteins for ASXL2 (Q76L832, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRPF40AO754002, 3MINT-61856 I2D: score=3 
    BAP1Q925603I2D: score=2 
    EEDO755303I2D: score=2 
    EZH2Q159103I2D: score=2 
    TRAF6Q9Y4K33I2D: score=2 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0035360positive regulation of peroxisome proliferator activated receptor signaling pathway IDA--
    GO:0045600positive regulation of fat cell differentiation IDA--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA--

    ASXL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ASXL2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ASXL2 gene: 
    NM_018263.4  

    Unigene Cluster for ASXL2:

    Additional sex combs like 2 (Drosophila)
    Hs.119815  [show with all ESTs]
    Unigene Representative Sequence: BX648218
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000435504 ENST00000404843(uc002rgt.1) ENST00000497092 ENST00000336112(uc002rgs.2)
    ENST00000272341

    miRNA
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    Block miRNA regulation of human, mouse, rat ASXL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ASXL2 (see all 77):
    hsa-miR-548j hsa-miR-323-3p hsa-miR-549 hsa-miR-520e hsa-miR-300 hsa-miR-519a hsa-miR-890 hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidASXL2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ASXL2
    Predesigned siRNA for gene silencing in human, mouse, rat ASXL2
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    GenScript: all cDNA clones in your preferred vector: ASXL2 (NM_018263)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ASXL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASXL2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ASXL2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ASXL2
      QuantiTect SYBR Green Assays in human, mouse, rat ASXL2
      QuantiFast Probe-based Assays in human, mouse, rat ASXL2

    Additional mRNA sequence: 

    AB051472.2 AB084279.1 AK000649.1 AK001760.1 BC042999.2 BX647527.1 BX648218.1 CR933613.1 
    FJ230888.1 

    9 DOTS entries:

    DT.97838913  DT.101983488  DT.121031024  DT.444941  DT.121030993  DT.70105140  DT.91854209  DT.92013785 
    DT.97793898 

    Selected AceView cDNA sequences (see all 218):

    AI347313 AB084279 BX498174 BM992125 AI935493 BQ025353 AA907848 CK823034 
    AI304650 AA458864 CN482374 AB051472 CB216451 BE550706 AI147402 AI378062 
    AI273375 AW571857 BQ100965 BM742611 BM742015 AA947136 BX280169 AA505830 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ASXL2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c
    SP1:                                                                                          
    SP2:                                                                          -               


    ECgene alternative splicing isoforms for ASXL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ASXL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ASXL2 Expression
    About this image

    ASXL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ASXL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.119815
        Pathway & Disease-focused RT2 Profiler PCR Array including ASXL2: 
              Polycomb & Trithorax Complexes in human mouse rat

    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASXL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ASXL2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Asxl21 , 5 additional sex combs like 2 (Drosophila)1, 5 85.46(n)1
    81.52(a)1
      12 (1.81 cM)5
    753021  NM_001270988.11  NP_001257917.11 
     34268575 
    chicken
    (Gallus gallus)
    Aves ASXL21 additional sex combs like 2 (Drosophila) 66.54(n)
    62.54(a)
      421993  NM_001031096.1  NP_001026267.1 
    lizard
    (Anolis carolinensis)
    Reptilia ASXL26
    additional sex combs like 2 (Drosophila)
    62(a)
    1 ↔ 1
    AAWZ02038845(21-9546)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1001502671 putative Polycomb group protein ASXL2-like 60.86(n)
    58.23(a)
      100150267  XM_005158856.1  XP_005158913.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Asx6
    Additional sex combs
    14(a)
    1 → many
    2R(10391463-10399998)


    ENSEMBL Gene Tree for ASXL2 (if available)
    TreeFam Gene Tree for ASXL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ASXL2 gene
    ASXL32  ASXL12  
    1 SIMAP similar gene for ASXL2 using alignment to 2 protein entries:     ASXL2_HUMAN (see all proteins):
    ASXL1

    ASXL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ASXL2 (see all 2563)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1408118301,2
    C--25961766(+) CCACAG/TATAGC 1 -- ds50010--------
    rs1865401931,2
    --25961907(+) TTTACC/TAGACA 1 -- ds50010--------
    rs133924711,2
    C,F,H--25962237(+) TAATGT/AGtttt 1 -- ds50015Minor allele frequency- A:0.01NS EA WA 532
    rs173920591,2
    C,F,H--25962324(+) ATAAAT/CAGACT 1 -- ut3116Minor allele frequency- C:0.03NA NS EA 1902
    rs1897437491,2
    --25962347(+) ACTACC/TCAACT 1 -- ut310--------
    rs1830698201,2
    --25962502(+) CCTATC/GTATAA 1 -- ut310--------
    rs1887665711,2
    --25962616(+) TAAGTA/TAAGGG 1 -- ut310--------
    rs1932951211,2
    --25962745(+) CAGCAC/TGCAGA 1 -- ut310--------
    rs1161575111,2
    C,F--25962759(+) GCCCTC/TGGCCC 1 -- ut311Minor allele frequency- T:0.03WA 118
    rs1447624021,2
    --25962839(+) TCCTGA/GATTGC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ASXL2 (25956622 - 26101385 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ASXL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2676793CNV Deletion23128226
    nsv873744CNV Loss21882294
    nsv873743CNV Loss21882294
    esv33316CNV Loss17666407
    nsv508716CNV Loss20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ASXL2
    DNA2.0 Custom Variant and Variant Library Synthesis for ASXL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612991    OMIM disorders: --

    UniProtKB/Swiss-Prot: ASXL2_HUMAN, Q76L83
  • Note=A chromosomal aberration involving ASXL2 is a cause of therapy-related myelodysplastic syndrome.
    Translocation t(2;8)(p23;p11.2) with KAT6A generates a KAT6A-ASXL2 fusion protein

  • 5 diseases for ASXL2:    
    About MalaCards
    coloboma    myelodysplastic syndromes    hiv-1    multiple myeloma
    myeloma


    ASXL2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Genetic Association Database (GAD): ASXL2
    Human Genome Epidemiology (HuGE) Navigator: ASXL2 (2 documents)

    Export disorders for ASXL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ASXL2 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with ASXL2)
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    1. Identification and characterization of ASXL2 gene in silico. (PubMed id 12888926)1, 3, 9 Katoh M. and Katoh M. (Int. J. Oncol. 2003)
    2. Additional sex comb-like (ASXL) proteins 1 and 2 play opposite roles in adipogenesis via reciprocal regulation of peroxisome proliferator- activated receptor {gamma}. (PubMed id 21047783)1, 2 Park U.H.... Um S.J. (J. Biol. Chem. 2011)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55252 HGNC: 23805 AceView: ASXL2 Ensembl:ENSG00000143970 euGenes: HUgn55252
    ECgene: ASXL2 H-InvDB: ASXL2

    (According to HUGE)
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    HUGE: KIAA1685

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ASXL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ASXL2 gene:
    Search GeneIP for patents involving ASXL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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