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Aliases for ASUN Gene

Aliases for ASUN Gene

  • Asunder, Spermatogenesis Regulator 2 3
  • Asunder, Spermatogenesis Regulator Homolog (Drosphila) 2 3
  • Cell Cycle Regulator Mat89Bb Homolog 3 4
  • Asunder Spermatogenesis Regulator 3 5
  • Spermatogenesis Associated 30 2 3
  • Sarcoma Antigen NY-SAR-95 3 4
  • Germ Cell Tumor 1 3 4
  • C12orf11 3 4
  • GCT1 3 4
  • Chromosome 12 Open Reading Frame 11 2
  • Mat89Bb 3
  • SPATA30 3
  • NET48 3

External Ids for ASUN Gene

Previous HGNC Symbols for ASUN Gene

  • C12orf11

Previous GeneCards Identifiers for ASUN Gene

  • GC12M027059

Summaries for ASUN Gene

GeneCards Summary for ASUN Gene

ASUN (Asunder, Spermatogenesis Regulator) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA Polymerase II Transcription Initiation And Promoter Clearance.

UniProtKB/Swiss-Prot for ASUN Gene

  • Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis.

Gene Wiki entry for ASUN Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASUN Gene

Genomics for ASUN Gene

Regulatory Elements for ASUN Gene

Enhancers for ASUN Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ASUN on UCSC Golden Path with GeneCards custom track

Promoters for ASUN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ASUN on UCSC Golden Path with GeneCards custom track

Genomic Location for ASUN Gene

Chromosome:
12
Start:
26,905,057 bp from pter
End:
26,938,326 bp from pter
Size:
33,270 bases
Orientation:
Minus strand

Genomic View for ASUN Gene

Genes around ASUN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASUN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASUN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASUN Gene

Proteins for ASUN Gene

  • Protein details for ASUN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVM9-ASUN_HUMAN
    Recommended name:
    Protein asunder homolog
    Protein Accession:
    Q9NVM9
    Secondary Accessions:
    • B4DNK1
    • Q86WE2
    • Q96HM2
    • Q9BTX2
    • Q9NTB6
    • Q9NVM5

    Protein attributes for ASUN Gene

    Size:
    706 amino acids
    Molecular mass:
    80225 Da
    Quaternary structure:
    • Interacts with PAFAH1B1; this interaction may be required for proper recruitment of dynein complexes to the nuclear envelope at prophase.
    Miscellaneous:
    • RNAi in HeLa cells results in a multinucleated phenotype.
    SequenceCaution:
    • Sequence=AAO65180.1; Type=Frameshift; Positions=414, 445, 483, 498, 507; Evidence={ECO:0000305};

    Alternative splice isoforms for ASUN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASUN Gene

Proteomics data for ASUN Gene at MOPED

Post-translational modifications for ASUN Gene

  • Ubiquitination at Lys 73 and Lys 436
  • Modification sites at PhosphoSitePlus

Other Protein References for ASUN Gene

No data available for DME Specific Peptides for ASUN Gene

Domains & Families for ASUN Gene

Protein Domains for ASUN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ASUN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NVM9

UniProtKB/Swiss-Prot:

ASUN_HUMAN :
  • Belongs to the asunder family.
Family:
  • Belongs to the asunder family.
genes like me logo Genes that share domains with ASUN: view

No data available for Gene Families for ASUN Gene

Function for ASUN Gene

Molecular function for ASUN Gene

UniProtKB/Swiss-Prot Function:
Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis.

Phenotypes for ASUN Gene

genes like me logo Genes that share phenotypes with ASUN: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ASUN Gene

Localization for ASUN Gene

Subcellular locations from UniProtKB/Swiss-Prot for ASUN Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ASUN Gene COMPARTMENTS Subcellular localization image for ASUN gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ASUN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,ISS --
genes like me logo Genes that share ontologies with ASUN: view

Pathways & Interactions for ASUN Gene

genes like me logo Genes that share pathways with ASUN: view

Pathways by source for ASUN Gene

Gene Ontology (GO) - Biological Process for ASUN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007346 regulation of mitotic cell cycle IMP 15737938
GO:0030317 sperm motility ISS --
GO:0042795 snRNA transcription from RNA polymerase II promoter TAS --
GO:0051301 cell division IEA --
GO:0051642 centrosome localization IMP 23097494
genes like me logo Genes that share ontologies with ASUN: view

No data available for SIGNOR curated interactions for ASUN Gene

Drugs & Compounds for ASUN Gene

No Compound Related Data Available

Transcripts for ASUN Gene

Unigene Clusters for ASUN Gene

Asunder, spermatogenesis regulator:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ASUN Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - - -
SP2: -
SP3: -
SP4:
SP5: -
SP6:
SP7: -
SP8:
SP9:

ExUns: 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for ASUN Gene

GeneLoc Exon Structure for
ASUN
ECgene alternative splicing isoforms for
ASUN

Expression for ASUN Gene

mRNA expression in normal human tissues for ASUN Gene

Protein differential expression in normal tissues from HIPED for ASUN Gene

This gene is overexpressed in Breast (29.0) and Peripheral blood mononuclear cells (15.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ASUN Gene



SOURCE GeneReport for Unigene cluster for ASUN Gene Hs.505077

mRNA Expression by UniProt/SwissProt for ASUN Gene

Q9NVM9-ASUN_HUMAN
Tissue specificity: Widely expressed. Tends to be up-regulated in seminomas compared to normal testis.
genes like me logo Genes that share expression patterns with ASUN: view

Protein tissue co-expression partners for ASUN Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ASUN Gene

Orthologs for ASUN Gene

This gene was present in the common ancestor of animals.

Orthologs for ASUN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ASUN 35
  • 94.38 (n)
  • 99.15 (a)
C5H12ORF11 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ASUN 35
  • 95.23 (n)
  • 98.73 (a)
ASUN 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Asun 35
  • 88.67 (n)
  • 95.61 (a)
Asun 16
Asun 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ASUN 35
  • 99.91 (n)
  • 100 (a)
ASUN 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Asun 35
  • 88.82 (n)
  • 95.4 (a)
oppossum
(Monodelphis domestica)
Mammalia ASUN 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ASUN 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1H12ORF11 35
  • 83.71 (n)
  • 94.19 (a)
ASUN 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ASUN 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia asun 35
  • 72.1 (n)
  • 86.12 (a)
Str.10184 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.25220 35
zebrafish
(Danio rerio)
Actinopterygii asun 35
  • 70.09 (n)
  • 80.63 (a)
wufi39e09 35
asun 36
  • 80 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002295 35
  • 46.99 (n)
  • 47.18 (a)
fruit fly
(Drosophila melanogaster)
Insecta asun 35
  • 48.32 (n)
  • 44.04 (a)
asun 36
  • 38 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_R02D3.4 35
  • 43.52 (n)
  • 29.49 (a)
R02D3.4 36
  • 24 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToOne
Species with no ortholog for ASUN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ASUN Gene

ENSEMBL:
Gene Tree for ASUN (if available)
TreeFam:
Gene Tree for ASUN (if available)

Paralogs for ASUN Gene

No data available for Paralogs for ASUN Gene

Variants for ASUN Gene

Sequence variations from dbSNP and Humsavar for ASUN Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_035673 A colorectal cancer sample
VAR_050864 -
rs2029309 -- 26,928,633(+) CTCTA(C/G)TATTC intron-variant
rs2029310 -- 26,928,940(+) CAAGA(A/G)TATGT intron-variant
rs2046692 -- 26,912,090(-) GTTAC(C/T)CATCA intron-variant

Variation tolerance for ASUN Gene

Residual Variation Intolerance Score: 9.54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.34; 41.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ASUN Gene

HapMap Linkage Disequilibrium report
ASUN
Human Gene Mutation Database (HGMD)
ASUN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ASUN Gene

Disorders for ASUN Gene

Relevant External Links for ASUN

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ASUN

No disorders were found for ASUN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASUN Gene

Publications for ASUN Gene

  1. Human Asunder promotes dynein recruitment and centrosomal tethering to the nucleus at mitotic entry. (PMID: 23097494) Jodoin J.N. … Lee L.A. (Mol. Biol. Cell 2012) 2 3 4 67
  2. Asunder is a critical regulator of dynein-dynactin localization during Drosophila spermatogenesis. (PMID: 19357193) Anderson M.A. … Lee L.A. (Mol. Biol. Cell 2009) 2 3
  3. Genomic and expression analysis of the 12p11-p12 amplicon using EST arrays identifies two novel amplified and overexpressed genes. (PMID: 12414650) Bourdon V. … Chaganti R.S. (Cancer Res. 2002) 2 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for ASUN Gene

Sources for ASUN Gene

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