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ASTN1 Gene

protein-coding   GIFtS: 51
GCID: GC01M176826

Astrotactin 1

(Previous name: astrotactin)
(Previous symbol: ASTN)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Astrotactin 11 2
ASTN1 2 3 5
astrotactin1
astrotactin-12
KIAA02893

External Ids:    HGNC: 7731   Entrez Gene: 4602   Ensembl: ENSG000001520927   OMIM: 6009045   UniProtKB: O145253   

Export aliases for ASTN1 gene to outside databases

Previous GC identifers: GC01M175093 GC01M148056


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ASTN1 Gene:
Astrotactin is a neuronal adhesion molecule required for glial-guided migration of young postmitotic neuroblasts
in cortical regions of developing brain, including cerebrum, hippocampus, cerebellum, and olfactory bulb (Fink et
al., 1995).(supplied by OMIM, Jun 2009)

GeneCards Summary for ASTN1 Gene:
ASTN1 (astrotactin 1) is a protein-coding gene. An important paralog of this gene is ASTN2.

UniProtKB/Swiss-Prot: ASTN1_HUMAN, O14525
Function: Neuronal adhesion molecule that is required for glial-guided migration of young postmitotic neuroblasts
in cortical regions of developing brain, including cerebrum, hippocampus, cerebellum and olfactory bulb




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the ASTN1 gene promoter:
         Nkx3-1   Nkx3-1 v4   Pbx1a   Nkx3-1 v1   Nkx2-5   AP-4   Nkx3-1 v2   SRY   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidASTN1 promoter sequence
   Search Chromatin IP Primers for ASTN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ASTN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25.2   Ensembl cytogenetic band:  1q25.2   HGNC cytogenetic band: 1q25.2

ASTN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASTN1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M176826:  view genomic region     (about GC identifiers)

Start:
176,826,438 bp from pter      End:
177,134,109 bp from pter
Size:
307,672 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ASTN1_HUMAN, O14525 (See protein sequence)
Recommended Name: Astrotactin-1 precursor  
Size: 1302 amino acids; 144913 Da
Sequence caution: Sequence=BAA22958.1; Type=Erroneous initiation;
Secondary accessions: A5PL12 B4DHI9 E9PFR8 O60799 Q5W0V7 Q5W0V8
Alternative splicing: 3 isoforms:  O14525-1   O14525-2   O14525-3   (Ref.2 (BAG58151) sequence is in conflict in position: 1216:R->RYQ)

Explore the universe of human proteins at neXtProt for ASTN1: NX_O14525

Explore proteomics data for ASTN1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn115, Asn226, Asn382, Asn453, Asn729, Asn742, Asn804, Asn984
  • Modification sites at PhosphoSitePlus

  • See ASTN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001273093.1  NP_004310.1  NP_996991.1  

    ENSEMBL proteins: 
     ENSP00000356629   ENSP00000354536   ENSP00000395041   ENSP00000356626  

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    Cloud-Clone Corp. Proteins for ASTN1

     
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    Search eBioscience for ELISAs for ASTN1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR000742 EG-like_dom
     IPR003961 Fibronectin_type3
     IPR020864 MACPF
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry O14525

    ProtoNet protein and cluster: O14525

    1 Blocks protein domain: IPB006210 Type I EGF

    UniProtKB/Swiss-Prot: ASTN1_HUMAN, O14525
    Similarity: Belongs to the astrotactin family
    Similarity: Contains 3 EGF-like domains
    Similarity: Contains 1 fibronectin type-III domain


    Find genes that share domains with ASTN1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ASTN1_HUMAN, O14525
    Function: Neuronal adhesion molecule that is required for glial-guided migration of young postmitotic neuroblasts
    in cortical regions of developing brain, including cerebrum, hippocampus, cerebellum and olfactory bulb

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with ASTN1           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Astn1):
     behavior/neurological  cellular  nervous system 

    Find genes that share phenotypes with ASTN1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Astn1tm1Hatn for ASTN1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ASTN1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ASTN1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ASTN1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ASTN1

    miRNA
    Products:
        
    miRTarBase miRNAs that target ASTN1:
    hsa-mir-335-5p (MIRT019216)

    Block miRNA regulation of human, mouse, rat ASTN1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ASTN1 (see all 23):
    hsa-miR-4328 hsa-miR-330-5p hsa-miR-875-5p hsa-miR-25 hsa-miR-1271 hsa-miR-200a hsa-miR-885-5p hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidASTN1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ASTN1

    Gene Editing
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    OriGene ORF clones in mouse, rat for ASTN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ASTN1 (NM_004319)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ASTN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASTN1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ASTN1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASTN1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ASTN1_HUMAN, O14525: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    extracellular2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005768endosome IEA--
    GO:0009897external side of plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with ASTN1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ASTN1
    Interactions:

        Search GeneGlobe Interaction Network for ASTN1

    1 Interacting protein for ASTN1 (O145253) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHABP319463I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001764neuron migration IEA--
    GO:0007158neuron cell-cell adhesion IEA--
    GO:0007626locomotory behavior IEA--
    GO:0016337cell-cell adhesion ----
    GO:0016477cell migration ----

    Find genes that share ontologies with ASTN1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ASTN1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ASTN1 gene (3 alternative transcripts): 
    NM_001286164.1  NM_004319.2  NM_207108.2  

    Unigene Cluster for ASTN1:

    Astrotactin 1
    Hs.495897  [show with all ESTs]
    Unigene Representative Sequence: NM_004319
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367657(uc001glb.1 uc001gld.1) ENST00000361833(uc001glc.3)
    ENST00000424564 ENST00000281881(uc009wwx.1) ENST00000473640(uc001gle.4)
    ENST00000367654
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ASTN1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ASTN1 (see all 23):
    hsa-miR-4328 hsa-miR-330-5p hsa-miR-875-5p hsa-miR-25 hsa-miR-1271 hsa-miR-200a hsa-miR-885-5p hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidASTN1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ASTN1
    Predesigned siRNA for gene silencing in human, mouse, rat ASTN1
    Clone
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    OriGene clones in human, mouse for ASTN1 (see all 12)
    OriGene ORF clones in mouse, rat for ASTN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ASTN1 (NM_004319)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ASTN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASTN1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ASTN1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ASTN1
      QuantiTect SYBR Green Assays in human, mouse, rat ASTN1
      QuantiFast Probe-based Assays in human, mouse, rat ASTN1

    Additional mRNA sequence: 

    AB006627.1 AK295126.1 AK307820.1 AK309094.1 BC015438.1 BC032870.1 BC049377.1 BC064147.1 
    BC142697.1 BC146795.1 

    5 DOTS entries:

    DT.99979924  DT.101978405  DT.100755034  DT.100718674  DT.100738106 

    Selected AceView cDNA sequences (see all 127):

    AI380069 BC064147 BU620695 BE047923 BF594232 F09135 AB006627 NM_207108 
    R59057 T08472 BC015438 Z39954 BM722747 T33100 F03156 CR618154 
    T08055 F02075 T16766 T08714 NM_004319 BM683113 AI333790 BM682135 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ASTN1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
    SP1:              -                                                                 -     -                                                                     
    SP2:                                                                                                                                                            
    SP3:                                                              -                                                                                             
    SP4:                                                                                                                                                            

    ExUns: 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26
    SP1:                          -         
    SP2:                                    
    SP3:                                    
    SP4:                                    


    ECgene alternative splicing isoforms for ASTN1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ASTN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGTTTGGTC
    ASTN1 Expression
    About this image


    ASTN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Spinal Cord (Nervous System)
             Oligodendrocyte progenitor cells
     
     Brain (Nervous System)
             Oligodendrocyte progenitor cells
     
     Limb (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Bone (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Cartilage (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
    ASTN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ASTN1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.495897
        Custom PCR Arrays for ASTN1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASTN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ASTN1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Astn11 , 5 astrotactin 11, 5 90.81(n)1
    97.97(a)1
      1 (68.35 cM)5
    118991  NM_007495.41  NP_031521.21 
     1583623045 
    chicken
    (Gallus gallus)
    Aves ASTN11 astrotactin 1 83.22(n)
    93.39(a)
      429070  XM_004943258.1  XP_004943315.1 
    lizard
    (Anolis carolinensis)
    Reptilia ASTN16
    astrotactin 1
    88(a)
    1 ↔ 1
    4(72962994-73248665)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia astn11 astrotactin 1 74.2(n)
    82.35(a)
      779977  NM_001079054.1  NP_001072522.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.147292 Transcribed sequence with moderate similarity to protein more 78.16(n)    CK362652.1 


    ENSEMBL Gene Tree for ASTN1 (if available)
    TreeFam Gene Tree for ASTN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ASTN1 gene
    ASTN22  
    1 SIMAP similar gene for ASTN1 using alignment to 4 protein entries:     ASTN1_HUMAN (see all proteins):
    ASTN2

    Find genes that share paralogs with ASTN1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ASTN1 (see all 5760)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1915271781,2
    --176829740(+) CTTTTC/GCAACA 1 -- ds50010--------
    rs794304611,2
    C--176829745(+) TTTTT-/TTTCTTCA 1 -- cds10--------
    rs1158546911,2
    C,F--176829945(+) AGCAGC/TTGTGC 1 -- ds50011Minor allele frequency- T:0.01NA 120
    rs1835459391,2
    --176829957(+) ACAAAC/TACATT 1 -- ds50010--------
    rs66993531,2
    C,H--176830002(+) GAAGAT/AGGGAC 1 -- ds50014Minor allele frequency- A:0.00NS EA 414
    rs1163054831,2
    F--176830158(+) TCTAAC/TCAGTT 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1880737861,2
    --176830325(+) TTCCTC/TCTGCA 1 -- ut310--------
    rs1928253781,2
    --176830437(+) AAAACA/G/TATTGC 2 -- ut310--------
    rs412671441,2
    C,F--176830826(+) CGTGTG/ATGTGT 1 -- ut314Minor allele frequency- A:0.09NA EA 244
    rs64253971,2
    C,F,A,H--176830978(+) GGAGAT/CTGAGG 1 -- ut31 ese324Minor allele frequency- C:0.15NS EA NA WA CSA 2342

    HapMap Linkage Disequilibrium report for ASTN1 (176826438 - 177076438 bp, first 250kb of ASTN1)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ASTN1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2673141CNV Deletion23128226
    nsv3677CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ASTN1
    DNA2.0 Custom Variant and Variant Library Synthesis for ASTN1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600904    OMIM disorders: --


    Find genes that share disorders with ASTN1           About GenesLikeMe

    Genetic Association Database (GAD): ASTN1
    Human Genome Epidemiology (HuGE) Navigator: ASTN1 (4 documents)

    Export disorders for ASTN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ASTN1 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with ASTN1)
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    1. Astrotactin (ASTN), a gene for glial-guided neuronal migration, maps to human chromosome 1q25.2. (PubMed id 9070947)1, 3, 9 Fink J.M....Ross M.E. (Genomics 1997)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    4. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826)1, 4 Uhl G.R....Lerman C. (Arch. Gen. Psychiatry 2008)
    5. Association analysis of schizophrenia on 18 genes involved in neuronal migration: MDGA1 as a new susceptibility gene. (PubMed id 18384059)1, 4 KAohler A.K....Andreassen O.A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    7. Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins. (PubMed id 9179496)1, 2 Ohara O....Nomura N. (DNA Res. 1997)
    8. ASTN1 and alcohol dependence: family-based association analysis in multiplex alcohol dependence families. (PubMed id 22488871)1 Hill S.Y....Stiffler S. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2012)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 460 HGNC: 773 AceView: ASTN Ensembl:ENSG00000152092 euGenes: HUgn460
    ECgene: ASTN1 H-InvDB: ASTN1

    (According to HUGE)
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    HUGE: KIAA0289

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ASTN1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ASTN1 gene:
    Search GeneIP for patents involving ASTN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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