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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ASTN1 Gene

protein-coding GIFtS: 47
GCID: GC01M176826

astrotactin 1

(Previous name: astrotactin )
(Previous symbol: ASTN)

Explore 2 diseases affiliated with
ASTN1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Astrotactin 1¹ ²
ASTN¹ ² ³ ⁵
Astrotactin¹
Astrotactin-1¹
KIAA0289³

External Ids:	HGNC: 773¹	Entrez Gene: 460²	Ensembl: ENSG00000152092⁷	OMIM: 600904⁵	UniProtKB: O14525³

Export aliases for ASTN1 gene to outside databases

Previous GC identifers: GC01M175093 GC01M148056

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ASTN1:

Astrotactin is a neuronal adhesion molecule required for glial-guided migration of young postmitotic neuroblasts in

cortical regions of developing brain, including cerebrum, hippocampus, cerebellum, and olfactory bulb (Fink et al.,

1995).(supplied by OMIM, Jun 2009)

UniProtKB/Swiss-Prot: ASTN1_HUMAN, O14525

Function: Neuronal adhesion molecule that is required for glial-guided migration of young postmitotic neuroblasts in

cortical regions of developing brain, including cerebrum, hippocampus, cerebellum and olfactory bulb

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ASTN1 gene promoter:
Nkx3-1 Nkx3-1 v4 Pbx1a Nkx3-1 v1 Nkx2-5 AP-4 Nkx3-1 v2 SRY NF-Y CBF(2)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ASTN1 promoter sequence

Search SABiosciences Chromatin IP Primers for ASTN1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASTN1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25.2 Ensembl cytogenetic band: 1q25.2 HGNC cytogenetic band: 1q25.2

ASTN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASTN1 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M176826: view genomic region (about GC identifiers)

Start:	176,826,438 bp from pter	End:	177,134,109 bp from pter
Size:	307,672 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ASTN1_HUMAN, O14525 (See protein sequence)

Recommended Name: Astrotactin-1 precursor

Size: 1302 amino acids; 144913 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Sequence caution: Sequence=BAA22958.1; Type=Erroneous initiation;

Secondary accessions: A5PL12 B4DHI9 E9PFR8 O60799 Q5W0V7 Q5W0V8

Alternative splicing: 3 isoforms: O14525-1 O14525-2 O14525-3 (Ref.2 (BAG58151) sequence is in conflict in position: 1216:R->RYQ)

Explore the universe of human proteins at neXtProt for ASTN1: NX_O14525

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O14525

ASTN1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_004310.1 NP_996991.1

ENSEMBL proteins:

ENSP00000356629 ENSP00000354536 ENSP00000356626 ENSP00000395041

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for ASTN1
	GenScript Custom Purified and Recombinant Proteins Services for ASTN1
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ASTN1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0016021	integral to membrane	IEA	--

ASTN1 for ontologies About GeneDecksing

ASTN1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for ASTN1
	GenScript Custom Superior Antibodies Services for ASTN1
	Search for Antibodies for ASTN1 at Abcam
	Uscn Antibodies for ASTN1
	Search ThermoFisher Antibodies for ASTN1

Assay Products for ASTN1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ASTN1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ASTN1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ASTN1 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR026995 Astrotactin

IPR000742 EG-like_dom

IPR003961 Fibronectin_type3

IPR026996 Astrotactin_1

IPR020864 MACPF

Graphical View of Domain Structure for InterPro Entry O14525

ProtoNet protein and cluster: O14525

1 Blocks protein family: IPB006210 Type I EGF

UniProtKB/Swiss-Prot: ASTN1_HUMAN, O14525

Similarity: Belongs to the astrotactin family

Similarity: Contains 3 EGF-like domains

Similarity: Contains 1 fibronectin type-III domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ASTN1_HUMAN, O14525

Function: Neuronal adhesion molecule that is required for glial-guided migration of young postmitotic neuroblasts in

cortical regions of developing brain, including cerebrum, hippocampus, cerebellum and olfactory bulb

miRNA Products:		OriGene 3'-UTR Clone (see all 2): ASTN1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ASTN1
		8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate ASTN1 (see all 23):
		hsa-miR-4328 hsa-miR-330-5p hsa-miR-875-5p hsa-miR-25 hsa-miR-1271 hsa-miR-200a hsa-miR-885-5p hsa-miR-141

		SwitchGear 3'UTR luciferase reporter plasmid: ASTN1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ASTN1 (see all 4) OriGene shRNA RFP: ASTN1 OriGene siRNA: ASTN1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ASTN1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ASTN1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASTN1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASTN1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): ASTN1 (NM_004319)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ASTN1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASTN1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ASTN1
		Search LifeMap BioReagents cell lines for ASTN1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASTN1

Animal Models:
Mouse knock-out Astn1^tm1Hatn for ASTN1
3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Astn1):

behavior/neurological

cellular

nervous system

ASTN1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ASTN1

1 Interacting protein for ASTN1 (O14525³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
YWHAB	P31946³	I2D: score=1

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007158	neuron cell-cell adhesion	NAS	--
GO:0007626	locomotory behavior	IEA	--
GO:0016337	cell-cell adhesion	--	--
GO:0016477	cell migration	NAS	--

ASTN1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ASTN1
Search CenterWatch for drugs/clinical trials and news about ASTN1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ASTN1 gene (2 alternative transcripts):

NM_004319.1 NM_207108.1

Unigene Cluster for ASTN1:

Astrotactin 1

Hs.495897 [show with all ESTs]

Unigene Representative Sequence: NM_004319

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000367657(uc001glb.1 uc001gld.1) ENST00000361833(uc001glc.3)

ENST00000367654 ENST00000424564 ENST00000281881(uc009wwx.1) ENST00000473640(uc001gle.4)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): ASTN1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ASTN1
		8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate ASTN1 (see all 23):
		hsa-miR-4328 hsa-miR-330-5p hsa-miR-875-5p hsa-miR-25 hsa-miR-1271 hsa-miR-200a hsa-miR-885-5p hsa-miR-141

		SwitchGear 3'UTR luciferase reporter plasmid: ASTN1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ASTN1 (see all 4) OriGene shRNA RFP: ASTN1 OriGene siRNA: ASTN1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ASTN1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASTN1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASTN1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): ASTN1 (NM_004319)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ASTN1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASTN1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ASTN1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ASTN1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ASTN1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASTN1

Additional cDNA sequence:

AB006627.1 AK295126.1 AK307820.1 AK309094.1 BC015438.1 BC032870.1 BC049377.1 BC064147.1

BC142697.1 BC146795.1

5 DOTS entries:

DT.99979924 DT.101978405 DT.100755034 DT.100718674 DT.100738106

24/127 AceView cDNA sequences (see all 127):

BM683113 Z39954 T33100 BM722747 AB006627 NM_207108 BE328137 BM682135

AI333790 CR618154 T08055 NM_004319 BE047923 F09135 BF594232 BC064147

BU620695 AI380069 T08714 F02075 T16766 F03156 R59057 T08472

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ASTN1 About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4a	·	4b	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16a	·	16b	^	17	^	18	^	19	^	20	^	21	^
SP1:					-																						-		-
SP2:
SP3:																					-
SP4:

ExUns:	22	^	23	^	24	^	25a	·	25b	^	26
SP1:									-
SP2:
SP3:
SP4:

ECgene alternative splicing isoforms for ASTN1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ASTN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGTTTGGTC

About this image

ASTN1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Zeugopod

Mesenchymal Condensate Cells

Bone, Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ASTN1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ASTN1

SOURCE GeneReport for Unigene cluster: Hs.495897

SABiosciences Custom PCR Arrays for ASTN1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ASTN1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ASTN1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ASTN1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASTN1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASTN1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ASTN1 gene from 3/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ASTN1¹	astrotactin 1	83.22(n) 93.31(a)		429070 XM_426626.3 XP_426626.3
lizard (Anolis carolinensis)	Reptilia	ASTN1⁶	--	90(a)	1 ↔ 1	4(72962994-73127810)
zebrafish (Danio rerio)	Actinopterygii	Dr.14729²	Transcribed sequence with moderate similarity to protein more	78.16(n)		CK362652.1

ENSEMBL Gene Tree for ASTN1 (if available)
TreeFam Gene Tree for ASTN1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ASTN1 gene

ASTN2²

1 SIMAP similar gene for ASTN1 using alignment to 4 protein entries: ASTN1_HUMAN (see all proteins):

ASTN2

ASTN1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs35493221^1,2	C,	--	148096856(+)	`GTAGC-/CAATAA`	1	--	int¹		2		NA	4
rs35062067^1,2	C	--	148102301(+)	`AAAAA-/AGAAAA`	1	--	int¹		2		NA	4
rs191527178^1,2		--	176829740(+)	`CTTTTC/GCAACA`	1	--	ds500¹		0	--	--	--	--
rs140205712^1,2	C,	--	176829745(+)	`CAACA-/TTTTTTTT`	1	--	ds500¹		0	--	--	--	--
rs79430461^1,2	C	--	176829746(+)	`TTTTT-/TTTCTTCA`	1	--	ds500¹		0	--	--	--	--
rs115854691^1,2		--	176829945(+)	`AGCAGC/TTGTGC`	1	--	ds500¹		1		NA	120
rs183545939^1,2		--	176829957(+)	`ACAAAC/TACATT`	1	--	ds500¹		0	--	--	--	--
rs6699353^1,2	C,H	--	176830002(+)	`GAAGAT/AGGGAC`	1	--	ds500¹		4		NS EA	414
rs116305483^1,2	F,	--	176830158(+)	`TCTAAC/TCAGTT`	1	--	ds500¹		1		WA	118
rs188073786^1,2		--	176830325(+)	`TTCCTC/TCTGCA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ASTN1 (176826438 - 177076438 bp, first 250kb of ASTN1)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ASTN1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ASTN1

DNA2.0 Custom Variant and Variant Library Synthesis for ASTN1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ASTN1 for disorders           About GeneDecksing

OMIM gene information: 600904    OMIM disorders: --

2 diseases for ASTN1:    About MalaCards

neuronitis schizophrenia

Human Genome Epidemiology (HuGE) Navigator: ASTN1 (4 documents)

Export disorders for ASTN1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ASTN1 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with ASTN1)

Utopia: connect your pdf to the dynamic
world of online information

Astrotactin (ASTN), a gene for glial-guided neuronal migration, maps to human chromosome 1q25.2. (PubMed id 9070947)^{1, 3, 9} Fink J.M....Ross M.E. (1997)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins. (PubMed id 9179496)^{1, 2} Ohara O....Nomura N. (1997)
ASTN1 and alcohol dependence: family-based association analysis in multiplex alcohol dependence families. (PubMed id 22488871)¹ Hill S.Y....Stiffler S. (2012)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826)¹ Uhl G.R....Lerman C. (2008)
Association analysis of schizophrenia on 18 genes involved in neuronal migration: MDGA1 as a new susceptibility gene. (PubMed id 18384059)¹ Kahler A.K....Andreassen O.A. (2008)
Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)¹ GratacA^s M....Carracedo A. (2008)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 460	HGNC: 773	AceView: ASTN	Ensembl:ENSG00000152092	euGenes: HUgn460
ECgene: ASTN1	H-InvDB: ASTN1

(According to HUGE)
About This Section

HUGE: KIAA0289

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ASTN1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ASTN1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ASTN1 gene:
Search GeneIP for patents involving ASTN1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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	Browse OriGene Antibodies		OriGene shRNA RFP for ASTN1
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ASTN1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ASTN1
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	OriGene siRNA for ASTN1		OriGene 3'-UTR Clone for ASTN1
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	OriGene Custom Antibody Services for ASTN1		OriGene Custom Protein Services for ASTN1
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ASTN1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ASTN1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASTN1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ASTN1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASTN1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ASTN1

	GenScript Custom Purified and Recombinant Proteins Services for ASTN1		GenScript cDNA clones with any tag delivered in your preferred vector for ASTN1
	GenScript Custom Assay Services for ASTN1		GenScript Custom Superior Antibodies Services for ASTN1
	GenScript Custom overexpressing Cell Line Services for ASTN1		CloneReady with Over 120,000 Genes
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	Regulatory tfbs in ASTN1 promoter
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASTN1

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Search ThermoFisher Antibodies for ASTN1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASTN1

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ASTN1 gene at Home site.

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ASTN1 Gene

astrotactin 1

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ASTN1 Gene

astrotactin 1

Aliasesfor ASTN1 gene

Summariesfor ASTN1 gene

Genomic Viewsfor ASTN1 gene

Proteinsfor ASTN1 gene

Protein Domains /Familiesfor ASTN1 gene

Functionfor ASTN1 gene

Pathways & Interactionsfor ASTN1 gene

Drugs & Compoundsfor ASTN1 gene

Transcriptsfor ASTN1 gene

Expression for ASTN1 gene

Orthologsfor ASTN1 gene

Paralogsfor ASTN1 gene

Genomic Variantsfor ASTN1 gene

Disorders / Diseasesfor ASTN1 gene

Publicationsfor ASTN1 gene

External Searches for ASTN1 gene

Genome Databases showing ASTN1 gene

Other Databases showing ASTN1 gene

Specialized Databases showing ASTN1 gene

Intellectual Propertyfor ASTN1 gene

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View Random Gene

Aliases
for ASTN1 gene

Summaries
for ASTN1 gene

Genomic Views
for ASTN1 gene

Proteins
for ASTN1 gene

Protein Domains /
Families
for ASTN1 gene

Function
for ASTN1 gene

Pathways & Interactions
for ASTN1 gene

Drugs & Compounds
for ASTN1 gene

Transcripts
for ASTN1 gene

Expression
for ASTN1 gene

Orthologs
for ASTN1 gene

Paralogs
for ASTN1 gene

Genomic Variants
for ASTN1 gene

Disorders / Diseases
for ASTN1 gene

Publications
for ASTN1 gene

Intellectual Property
for ASTN1 gene

Products
for ASTN1 gene