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Aliases for ASTN1 Gene

Aliases for ASTN1 Gene

  • Astrotactin 1 2 3
  • ASTN 3 4 6
  • Astrotactin-1 3
  • Astrotactin 2
  • KIAA0289 4

External Ids for ASTN1 Gene

Previous Symbols for ASTN1 Gene

  • ASTN

Summaries for ASTN1 Gene

Entrez Gene Summary for ASTN1 Gene

  • Astrotactin is a neuronal adhesion molecule required for glial-guided migration of young postmitotic neuroblasts in cortical regions of developing brain, including cerebrum, hippocampus, cerebellum, and olfactory bulb (Fink et al., 1995).[supplied by OMIM, Jun 2009]

GeneCards Summary for ASTN1 Gene

ASTN1 (Astrotactin 1) is a Protein Coding gene. An important paralog of this gene is ASTN2.

UniProtKB/Swiss-Prot for ASTN1 Gene

  • Neuronal adhesion molecule that is required for glial-guided migration of young postmitotic neuroblasts in cortical regions of developing brain, including cerebrum, hippocampus, cerebellum and olfactory bulb

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASTN1 Gene

Genomics for ASTN1 Gene

Genomic Location for ASTN1 Gene

Start:
176,857,302 bp from pter
End:
177,164,973 bp from pter
Size:
307,672 bases
Orientation:
Minus strand

Genomic View for ASTN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ASTN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASTN1 Gene

Regulatory Elements for ASTN1 Gene

Proteins for ASTN1 Gene

  • Protein details for ASTN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14525-ASTN1_HUMAN
    Recommended name:
    Astrotactin-1
    Protein Accession:
    O14525
    Secondary Accessions:
    • A5PL12
    • B4DHI9
    • E9PFR8
    • O60799
    • Q5W0V7
    • Q5W0V8

    Protein attributes for ASTN1 Gene

    Size:
    1302 amino acids
    Molecular mass:
    144913 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA22958.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ASTN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASTN1 Gene

Proteomics data for ASTN1 Gene at MOPED

Post-translational modifications for ASTN1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn115, Asn226, Asn382, Asn453, Asn729, Asn742, Asn804, and Asn984

Other Protein References for ASTN1 Gene

No data available for DME Specific Peptides for ASTN1 Gene

Domains for ASTN1 Gene

Protein Domains for ASTN1 Gene

UniProtKB/Swiss-Prot:

ASTN1_HUMAN
Domain:
  • Contains 3 EGF-like domains.:
    • O14525
  • Contains 1 fibronectin type-III domain.:
    • O14525
Family:
  • Belongs to the astrotactin family.:
    • O14525
genes like me logo Genes that share domains with ASTN1: view

No data available for Gene Families for ASTN1 Gene

Function for ASTN1 Gene

Molecular function for ASTN1 Gene

UniProtKB/Swiss-Prot Function: Neuronal adhesion molecule that is required for glial-guided migration of young postmitotic neuroblasts in cortical regions of developing brain, including cerebrum, hippocampus, cerebellum and olfactory bulb

Gene Ontology (GO) - Molecular Function for ASTN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ASTN1: view

Phenotypes for ASTN1 Gene

genes like me logo Genes that share phenotypes with ASTN1: view

Animal Models for ASTN1 Gene

MGI Knock Outs for ASTN1:

miRNA for ASTN1 Gene

miRTarBase miRNAs that target ASTN1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ASTN1 Gene

Localization for ASTN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ASTN1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ASTN1 Gene COMPARTMENTS Subcellular localization image for ASTN1 gene
Compartment Confidence
plasma membrane 3
extracellular 2

Gene Ontology (GO) - Cellular Components for ASTN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005768 endosome IEA --
GO:0009897 external side of plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ASTN1: view

Pathways for ASTN1 Gene

SuperPathways for ASTN1 Gene

No Data Available

Interacting Proteins for ASTN1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000354536%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000354536 O14525-ASTN1_HUMAN for ASTN1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for ASTN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration IEA --
GO:0007158 neuron cell-cell adhesion IEA --
GO:0007626 locomotory behavior IEA --
GO:0016337 single organismal cell-cell adhesion --
GO:0016477 cell migration --
genes like me logo Genes that share ontologies with ASTN1: view

No data available for Pathways by source for ASTN1 Gene

Transcripts for ASTN1 Gene

Unigene Clusters for ASTN1 Gene

Astrotactin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ASTN1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - -
SP2:
SP3: -
SP4:

ExUns: 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26
SP1: -
SP2:
SP3:
SP4:

Relevant External Links for ASTN1 Gene

GeneLoc Exon Structure for
ASTN1
ECgene alternative splicing isoforms for
ASTN1

Expression for ASTN1 Gene

mRNA expression in normal human tissues for ASTN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ASTN1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (5.5), Brain - Anterior cingulate cortex (BA24) (5.4), Brain - Cortex (5.3), Brain - Nucleus accumbens (basal ganglia) (5.0), and Brain - Amygdala (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ASTN1 Gene

SOURCE GeneReport for Unigene cluster for ASTN1 Gene Hs.495897

genes like me logo Genes that share expressions with ASTN1: view

Orthologs for ASTN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ASTN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ASTN1 36
  • 99.64 (n)
  • 99.77 (a)
ASTN1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ASTN1 36
  • 91.42 (n)
  • 98.17 (a)
ASTN1 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ASTN1 36
  • 92.83 (n)
  • 98.29 (a)
ASTN1 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Astn1 36
  • 90.81 (n)
  • 97.97 (a)
Astn1 16
Astn1 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ASTN1 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ASTN1 37
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Astn1 36
  • 90.92 (n)
  • 97.97 (a)
chicken
(Gallus gallus)
Aves ASTN1 36
  • 83.22 (n)
  • 93.39 (a)
ASTN1 37
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ASTN1 37
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia astn1 36
  • 74.2 (n)
  • 82.35 (a)
zebrafish
(Danio rerio)
Actinopterygii astn1 36
  • 74.03 (n)
  • 79.95 (a)
astn1 37
  • 78 (a)
OneToOne
Dr.14729 36
Species with no ortholog for ASTN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ASTN1 Gene

ENSEMBL:
Gene Tree for ASTN1 (if available)
TreeFam:
Gene Tree for ASTN1 (if available)

Paralogs for ASTN1 Gene

Paralogs for ASTN1 Gene

Selected SIMAP similar genes for ASTN1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ASTN1: view

Variants for ASTN1 Gene

Sequence variations from dbSNP and Humsavar for ASTN1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs21257 -- 176,988,464(-) CTAGG(A/G)ATAAG intron-variant
rs170570 -- 177,113,830(-) CACTC(C/G/T)CTCCA intron-variant
rs170591 -- 176,970,837(+) TAAGG(C/G)CTTTA intron-variant
rs170592 -- 176,997,071(+) AACCA(A/G)TTCCC intron-variant
rs172901 -- 177,105,400(-) TTAAG(A/G)TGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ASTN1 Gene

Variant ID Type Subtype PubMed ID
nsv3677 CNV Loss 18451855
esv2673141 CNV Deletion 23128226

Relevant External Links for ASTN1 Gene

HapMap Linkage Disequilibrium report
ASTN1

Disorders for ASTN1 Gene

Relevant External Links for ASTN1

Genetic Association Database (GAD)
ASTN1
Human Genome Epidemiology (HuGE) Navigator
ASTN1
genes like me logo Genes that share disorders with ASTN1: view

No data available for UniProtKB/Swiss-Prot for ASTN1 Gene

Publications for ASTN1 Gene

  1. Astrotactin (ASTN), a gene for glial-guided neuronal migration, maps to human chromosome 1q25.2. (PMID: 9070947) Fink J.M. … Ross M.E. (Genomics 1997) 2 3 23
  2. Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins. (PMID: 9179496) Ohara O. … Nomura N. (DNA Res. 1997) 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. Association analysis of schizophrenia on 18 genes involved in neuronal migration: MDGA1 as a new susceptibility gene. (PMID: 18384059) KAohler A.K. … Andreassen O.A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 49
  5. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PMID: 18519826) Uhl G.R. … Lerman C. (Arch. Gen. Psychiatry 2008) 3 49

Products for ASTN1 Gene

Sources for ASTN1 Gene

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