ASTL Gene
protein-coding GIFtS: 41
GCID: GC02M096789
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astacin-like metallo-endopeptidase (M12 family)(Previous name: astacin-like metalloendopeptidase (M12 family) )
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Aliases for ASTL gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Astacin-Like Metallo-Endopeptidase (M12 Family)1 2 | | Astacin-Like Metalloendopeptidase2 | | Astacin-Like Metalloendopeptidase (M12 Family)1 2 | | EC 3.4.-.-3 | | Ovastacin3 | | Ovastacin3 | | Oocyte Astacin2 3 | | |
Export aliases for ASTL gene to outside databasesPrevious GC identifers: GC00U914494 GC02M096211 GC02U900795 GC02M096153 GC02M090750 |
Summaries for ASTL gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: ASTL_HUMAN, Q6HA08Function: Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in thepolyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves thesperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, renderingthe zona pellucida unable to support further sperm binding (By similarity)
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Genomic Views for ASTL gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022171.15
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ASTL gene promoter: GR HEN1 AP-1 p53 GR-beta GR-alpha Pax-4a HNF-4alpha1 Other transcription factors
Search SABiosciences Chromatin IP Primers for ASTL
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASTL |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q11.1 Ensembl cytogenetic band: 2q11.2 HGNC cytogenetic band: 2q11.1ASTL Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M096789: view genomic region
(about GC identifiers)
Start:
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96,789,589 bp from pter |
End:
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96,804,175 bp from pter |
Size:
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14,587 bases |
Orientation:
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minus strand |
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Proteins for ASTL gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: ASTL_HUMAN, Q6HA08 (See
protein sequence)Recommended Name: Astacin-like metalloendopeptidase precursor Size: 431 amino acids; 45936 Da
Subunit: Interacts (via N-terminus domain) with SPACA3; the interaction occurs during fertilization (By similarity)
Subcellular location: Cytoplasm (By similarity). Cell membrane (By similarity). Cytoplasmic granule (By similarity).Cytoplasmic vesicle, secretory vesicle (By similarity). Note=Secretory granules. Localizes to the peripheral corticalgranules of ovulated eggs. Probably exocytosed from cortical granules during post-fertilization. Detected throughoutthe ooplasm of germinal vesicle stage oocytes in early bilaminar secondary follicles shortly after birth. Detected inthe microvillar domain of the oolemma in arrested ovulated secondary oocytes and in the first polar body prior tofertilization. Upon fertilization, detected in the perivitelline space (PVS). Colocalizes with SPACA3 at themicrovillar domain of the oolemma and in the perivitelline space (PVS) (By similarity)
Secondary accessions: Q3KNT0Explore the universe of human proteins at neXtProt for ASTL: NX_Q6HA08
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6HA08 ASTL Protein expression data from MOPED and PaxDb: About this image 
 REFSEQ proteins: NP_001002036.3 ENSEMBL proteins: ENSP00000343674 Human Recombinant Protein Products for ASTL:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
ASTL for ontologies About GeneDecksing
ASTL Antibody Products: Assay Products for ASTL: |
Protein
Domains / Families for ASTL gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ASTL for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6HA08ProtoNet protein and cluster: Q6HA08 1 Blocks protein family: IPB001506 Astacin family signature
UniProtKB/Swiss-Prot: ASTL_HUMAN, Q6HA08Similarity: Belongs to the peptidase M12A family |
Function for ASTL gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Molecular Function: UniProtKB/Swiss-Prot Summary: ASTL_HUMAN, Q6HA08Function: Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in thepolyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves thesperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, renderingthe zona pellucida unable to support further sperm binding (By similarity)Enzyme regulation: Inhibited by wide spectrum metalloproteinase inhibitor batimastat (BB-94). Also inhibited by EDTABiophysicochemical properties: Kinetic parameters: Note=Enzymatic activity was assayed using synthetic quenchedfluorescent substrates QF-24, QF-35 and QF-41. Astacin displayed the highest Kcat/KM value against QF-35; pHdependence: Optimum pH is 7.5; Enzyme Number (IUBMB): EC 3.4.-.-1
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
ASTL for ontologies About GeneDecksing
Phenotypes: 1 MGI mutant phenotype (inferred from 2 alleles ) (MGI details for Astl):
ASTL for phenotypes About GeneDecksing
Animal Models: Mouse knock-outs for ASTL: Astltm1Dean Astltm1Lex
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASTL (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASTL OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): ASTL (NM_032844) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ASTL | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASTL  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASTL |
|
Pathways & Interactions for ASTL gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ASTL
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
 1 Interacting protein for ASTL (ENSP000003436744) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
ASTL for ontologies About GeneDecksing
|
Drugs & Compounds for ASTL gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for ASTL Search CenterWatch for drugs/clinical trials and news about ASTL 
|
Transcripts for ASTL gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for ASTL gene: NM_001002036.3 Unigene Cluster for ASTL: Astacin-like metallo-endopeptidase (M12 family) Hs.447993 Unigene Representative Sequence: AJ5376002 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000342380(uc010yui.2) ENST00000470582
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASTL (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASTL OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): ASTL (NM_032844) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ASTL | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASTL  |
Additional cDNA sequence: AJ537600.2 BC107126.1 BC107127.1 1 DOTS entry: DT.120964892 GeneLoc Exon Structure
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Expression for ASTL gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ASTL expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GGTGGGAGTC
 About this image See ASTL Protein Expression from SPIRE MOPED and PaxDB SOURCE GeneReport for Unigene cluster: Hs.447993
UniProtKB/Swiss-Prot: ASTL_HUMAN, Q6HA08Tissue specificity: Expressed in promyelocytic leukemia HL-60 cells, Burkitt's lymphoma Raji cells, and also in someovarian carcinomas. Not detected in normal tissues SABiosciences Custom PCR Arrays for ASTL
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ASTL Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ASTL | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ASTL | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASTL | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASTL |
Orthologs for ASTL gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ASTL gene from 4/14 species (see all 14) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
chicken (Gallus gallus) |
Aves |
F1NU57_CHICK6 |
Uncharacterized protein |
13(a) |
1 ↔ 1 |
2(109536058-109561393) |
lizard (Anolis carolinensis) |
Reptilia |
ASTL6 |
-- |
71(a) |
1 ↔ 1 |
GL344471.1(37569-40051) |
fruit fly (Drosophila melanogaster) |
Insecta |
CG66966CG102806 |
-- |
26(a)25(a) |
possible orthologpossible ortholog |
X(18554522-18556186) 3R(1836295-1837654) |
worm (Caenorhabditis elegans) |
Secernentea |
nas-96 |
Zinc metalloproteinase nas-9 |
12(a) |
1 ↔ 1 |
V(4836014-4839996) |
ENSEMBL Gene Tree for ASTL (if available) TreeFam Gene Tree for ASTL (if available)  |
Paralogs for ASTL gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for ASTL gene
- MEP1A2 MEP1B2
ASTL for paralogs About GeneDecksing
|
Genomic Variants for ASTL gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 2 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for ASTL (96789589 - 96804175 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 3 variations for ASTL 3 CNVs: 89826 89827 89825  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ASTL |
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Disorders
/ Diseases for ASTL gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ASTL for disorders About GeneDecksing
OMIM gene information: 608860
OMIM disorders: --
4 diseases for ASTL: About MalaCardsburkitt's lymphoma ovarian carcinoma carcinoma leukemia Human Genome Epidemiology (HuGE) Navigator: ASTL (5 documents) Export disorders for ASTL gene to outside databases
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Publications for ASTL gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ASTL gene integrated from 9 sources: (articles sorted by number of sources associating them with ASTL) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Identification and characterization of human and mouse ovastacin, a novel metalloproteinase similar to hatching enzymes from arthropods, birds, amphibians, and fish. (PubMed id 15087446)1, 2, 3, 9 Quesada V.... Lopez-Otin C. (2004)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Meprins, membrane-bound and secreted astacin metalloproteinases. (PubMed id 18783725)9 Sterchi E.E....Bond J.S. (2008)
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External Searches for ASTL gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
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Genome Databases showing ASTL gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ASTL gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ASTL gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for ASTL | Pharmacogenomics, SNPs, Pathways | | Protein Spotlight | http://web.expasy.org/spotlight/back_issues/sptlt141.shtml |
|
| | |
About This Section
| Patent Information for ASTL gene: Search GeneIP for patents involving ASTL
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for ASTL gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory) About This Section
|
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 | |
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| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for ASTL | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ASTL | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ASTL | | OriGene Protein Over-expression Lysate for ASTL | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for ASTL | | Browse 3'-UTR reporter clones for miRNA target validation | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASTL | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASTL | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for ASTL | | OriGene Custom Protein Services for ASTL | | OriGene Custom Immunoassay Development | | |
| |  |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ASTL | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ASTL | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASTL | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ASTL | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASTL | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ASTL |
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 | | ASTL Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASTL |
|  |  |  |  | | | Search ThermoFisher Antibodies for ASTL |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASTL |
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