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ASTL Gene

protein-coding   GIFtS: 43
GCID: GC02M096789

Astacin-Like Metallo-Endopeptidase (M12 Family)

(Previous name: astacin-like metalloendopeptidase (M12 family))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Astacin-Like Metallo-Endopeptidase (M12 Family)1 2     ovastacin2
Astacin-Like Metalloendopeptidase (M12 Family)1 2     EC 3.4.-.-3
Oocyte Astacin2 3     Ovastacin3
Astacin-Like Metalloendopeptidase2     

External Ids:    HGNC: 317041   Entrez Gene: 4317052   Ensembl: ENSG000001888867   OMIM: 6088605   UniProtKB: Q6HA083   

Export aliases for ASTL gene to outside databases

Previous GC identifers: GC00U914494 GC02M096211 GC02U900795 GC02M096153 GC02M090750


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ASTL Gene:
ASTL (astacin-like metallo-endopeptidase (M12 family)) is a protein-coding gene. Diseases associated with ASTL include burkitt's lymphoma, and leukemia. GO annotations related to this gene include aspartic-type peptidase activity and metalloendopeptidase activity. An important paralog of this gene is MEP1A.

UniProtKB/Swiss-Prot: ASTL_HUMAN, Q6HA08
Function: Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in
the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the
sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis,
rendering the zona pellucida unable to support further sperm binding (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the ASTL gene promoter:
         GR   HEN1   AP-1   p53   GR-beta   GR-alpha   Pax-4a   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidASTL promoter sequence
   Search Chromatin IP Primers for ASTL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ASTL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.1   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q11.1

ASTL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASTL gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M096789:  view genomic region     (about GC identifiers)

Start:
96,789,589 bp from pter      End:
96,804,175 bp from pter
Size:
14,587 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ASTL_HUMAN, Q6HA08 (See protein sequence)
Recommended Name: Astacin-like metalloendopeptidase precursor  
Size: 431 amino acids; 45936 Da
Subunit: Interacts (via N-terminus domain) with SPACA3; the interaction occurs during fertilization (By
similarity)
Secondary accessions: Q3KNT0

Explore the universe of human proteins at neXtProt for ASTL: NX_Q6HA08

Explore proteomics data for ASTL at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ASTL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001002036.3  
    ENSEMBL proteins: 
     ENSP00000343674  

    ASTL Human Recombinant Protein Products:

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    ASTL Assay Products:

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    Cloud-Clone Corp. CLIAs for ASTL


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR024079 MetalloPept_cat_dom
     IPR001506 Peptidase_M12A
     IPR006026 Peptidase_Metallo

    Graphical View of Domain Structure for InterPro Entry Q6HA08

    ProtoNet protein and cluster: Q6HA08

    1 Blocks protein domain: IPB001506 Astacin family signature

    UniProtKB/Swiss-Prot: ASTL_HUMAN, Q6HA08
    Similarity: Belongs to the peptidase M12A family


    ASTL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ASTL_HUMAN, Q6HA08
    Function: Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in
    the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the
    sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis,
    rendering the zona pellucida unable to support further sperm binding (By similarity)
    Enzyme regulation: Inhibited by wide spectrum metalloproteinase inhibitor batimastat (BB-94). Also inhibited by
    EDTA
    Biophysicochemical properties: Kinetic parameters: Note=Enzymatic activity was assayed using synthetic quenched
    fluorescent substrates QF-24, QF-35 and QF-41. Astacin displayed the highest Kcat/KM value against QF-35; pH
    dependence: Optimum pH is 7.5;

         Enzyme Number (IUBMB): EC 3.4.-.-1

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IDA15087446
    GO:0005515protein binding ----
    GO:0008233peptidase activity IDA15087446
    GO:0008237metallopeptidase activity ----
    GO:0008270zinc ion binding IEA--
         
    ASTL for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Astl):
     reproductive system 

    ASTL for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ASTL: Astltm1Dean Astltm1Lex

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ASTL
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ASTL
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ASTL

    miRNA
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    miRTarBase miRNAs that target ASTL:
    hsa-mir-1226-3p (MIRT036503)

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    Predesigned siRNA for gene silencing in human, mouse, rat ASTL

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): ASTL (NM_032844)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ASTL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASTL

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASTL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ASTL_HUMAN, Q6HA08: Cytoplasm (By similarity). Cell membrane (By similarity). Cytoplasmic granule (By
    similarity). Cytoplasmic vesicle, secretory vesicle (By similarity). Note=Secretory granules. Localizes to the
    peripheral cortical granules of ovulated eggs. Probably exocytosed from cortical granules during
    post-fertilization. Detected throughout the ooplasm of germinal vesicle stage oocytes in early bilaminar
    secondary follicles shortly after birth. Detected in the microvillar domain of the oolemma in arrested ovulated
    secondary oocytes and in the first polar body prior to fertilization. Upon fertilization, detected in the
    perivitelline space (PVS). Colocalizes with SPACA3 at the microvillar domain of the oolemma and in the
    perivitelline space (PVS) (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular2
    cytosol1
    lysosome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--
    GO:0005886plasma membrane ISS--
    GO:0030133transport vesicle IEA--
    GO:0060473cortical granule ISS--

    ASTL for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ASTL
    Interactions:

        Search GeneGlobe Interaction Network for ASTL

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ASTL (ENSP000003436744) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDAC1ENSP000003626494STRING: ENSP00000362649
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IDA15087446
    GO:0007155cell adhesion ISS--
    GO:0009566fertilization ISS--
    GO:0010954positive regulation of protein processing ISS--
    GO:0060468prevention of polyspermy ISS--

    ASTL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ASTL



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ASTL gene: 
    NM_001002036.3  

    Unigene Cluster for ASTL:

    Astacin-like metallo-endopeptidase (M12 family)
    Hs.447993
    Unigene Representative Sequence: AJ537600
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000342380(uc010yui.2) ENST00000470582
    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ASTL
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    OriGene ORF clones in mouse, rat for ASTL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ASTL (NM_032844)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ASTL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASTL
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ASTL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ASTL
      QuantiTect SYBR Green Assays in human, mouse, rat ASTL
      QuantiFast Probe-based Assays in human, mouse, rat ASTL

    Additional mRNA sequence: 

    AJ537600.2 BC107126.1 BC107127.1 

    1 DOTS entry:

    DT.120964892 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ASTL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTGGGAGTC
    ASTL Expression
    About this image

    ASTL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ASTL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.447993

    UniProtKB/Swiss-Prot: ASTL_HUMAN, Q6HA08
    Tissue specificity: Expressed in promyelocytic leukemia HL-60 cells, Burkitt's lymphoma Raji cells, and also in
    some ovarian carcinomas. Not detected in normal tissues

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASTL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ASTL gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Astl1 , 5 astacin-like metalloendopeptidase (M12 family)1, 5 75.22(n)1
    68.7(a)1
      2 (61.93 cM)5
    2150951  NM_172539.21  NP_766127.11 
     1273386395 
    chicken
    (Gallus gallus)
    Aves ASTL6
    --
    Uncharacterized protein
    27(a)
    25(a)
    1 ↔ many
    1 ↔ many
    5(21649227-21661084)
    5(23499664-23510541)
    lizard
    (Anolis carolinensis)
    Reptilia ASTL6
    astacin-like metallo-endopeptidase (M12 family)
    71(a)
    1 ↔ 1
    GL344471.1(37569-40051)
    zebrafish
    (Danio rerio)
    Actinopterygii he1a6
    he1b6
    (see all 10)
    hatching enzyme 1b
    (see all 10)
    41(a)
    40(a)
    (see all 10)
    1 ↔ many
    1 ↔ many
    (see all 10)
    22(14237424-14238861) ENSDARG00000023656
    22(14242143-14243514) ENSDARG00000019122
    fruit fly
    (Drosophila melanogaster)
    Insecta CG57151 CG5715 49.59(n)
    42.79(a)
      42895  NM_142985.4  NP_651242.1 
    worm
    (Caenorhabditis elegans)
    Secernentea nas-16
    nas-66
    (see all 39)
    Protein NAS-6, isoform a
    (see all 39)
    30(a)
    27(a)
    (see all 39)
    1 ↔ many
    1 ↔ many
    (see all 39)
    III(13406000-13409286) WBGene00003520
    IV(17486982-17490497) WBGene00003525


    ENSEMBL Gene Tree for ASTL (if available)
    TreeFam Gene Tree for ASTL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ASTL gene
    MEP1A2  MEP1B2  

    ASTL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ASTL (see all 358)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1386938471,2
    --96789090(+) CTGGAA/GGCTAC 1 -- ds50010--------
    rs744403461,2
    C,F--96789466(+) GCCCTC/TTGAGA 1 -- ds50011Minor allele frequency- T:0.10EA 120
    rs729358911,2
    C,F--96789531(+) GTAGAC/TGACCC 1 -- ds50011Minor allele frequency- T:0.50WA 2
    rs2003644921,2
    C--96789582(+) GAAGCC/GACAGG 1 -- ds50011Minor allele frequency- G:0.00EU 1321
    rs2001610601,2
    --96789597(+) ATCTTC/TGGACA 2 K E mis10--------
    rs1421604461,2
    C,F--96789598(+) TCTTCG/AGACAT 2 /S syn11Minor allele frequency- A:0.00NA 4538
    rs112921691,2
    C--96789603(+) GGACAT/-CCCCT 2 /C /M fra11Minor allele frequency- -:0.00NA 2
    rs749969071,2
    C--96789610(+) CCCTTA/GAAATG 2 F syn10--------
    rs2008984991,2
    --96789737(+) GCTCCC/TGAGCA 2 Q R mis10--------
    rs2004466981,2
    C--96789747(+) AACACC/TGGGGG 2 S G mis10--------

    HapMap Linkage Disequilibrium report for ASTL (96789589 - 96804175 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ASTL:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2720410CNV Deletion23290073
    dgv650e201CNV Deletion23290073
    dgv4247n71CNV Loss21882294
    dgv4248n71CNV Loss21882294
    nsv874677CNV Loss21882294
    esv5003CNV Complex18987735

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ASTL
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608860    OMIM disorders: --

    2 diseases for ASTL:    
    About MalaCards
    burkitt's lymphoma    leukemia


    ASTL for disorders           About GeneDecksing

    Genetic Association Database (GAD): ASTL
    Human Genome Epidemiology (HuGE) Navigator: ASTL (5 documents)

    Export disorders for ASTL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ASTL gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ASTL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of human and mouse ovastacin, a novel metalloproteinase similar to hatching enzymes from arthropods, birds, amphibians, and fish. (PubMed id 15087446)1, 2, 3, 9 Quesada V.... Lopez-Otin C. (J. Biol. Chem. 2004)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. Meprins, membrane-bound and secreted astacin metalloproteinases. (PubMed id 18783725)9 Sterchi E.E....Bond J.S. (Mol. Aspects Med. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 431705 HGNC: 31704 Ensembl:ENSG00000188886 euGenes: HUgn431705 ECgene: ASTL
    H-InvDB: ASTL

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ASTL Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/141

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ASTL gene:
    Search GeneIP for patents involving ASTL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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