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Aliases for ASTE1 Gene

Aliases for ASTE1 Gene

  • Asteroid Homolog 1 2 3 5
  • Asteroid Homolog 1 (Drosophila) 2
  • Protein Asteroid Homolog 1 3
  • HT001 3

External Ids for ASTE1 Gene

Previous GeneCards Identifiers for ASTE1 Gene

  • GC03M132216
  • GC03M130732
  • GC03M128116

Summaries for ASTE1 Gene

GeneCards Summary for ASTE1 Gene

ASTE1 (Asteroid Homolog 1) is a Protein Coding gene. GO annotations related to this gene include nuclease activity.

UniProtKB/Swiss-Prot for ASTE1 Gene

  • Possible role in EGF receptor signaling.

Additional gene information for ASTE1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASTE1 Gene

Genomics for ASTE1 Gene

Regulatory Elements for ASTE1 Gene

Enhancers for ASTE1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H130745 1.1 ENCODE 15.6 +280.6 280569 3.3 HDGF PKNOX1 ATF1 ARID4B SIN3A DMAP1 BRCA1 YY1 ETS1 SLC30A9 PIK3R4 ASTE1 RN7SKP212
GH03H131380 1.3 ENCODE dbSUPER 10.1 -353.9 -353852 2.5 HDGF ATF1 ARID4B SIN3A FEZF1 DMAP1 ZBTB7B YY1 ZNF143 ZNF207 PIK3R4 ATP2C1 MRPL3 ASTE1 NUDT16 LOC339874
GH03H131221 0.2 ENCODE 9.9 -194.1 -194145 1.2 ASTE1 NEK11 NUDT16P1 RNU6-726P GC03M131093 GC03P131359
GH03H130843 0.4 ENCODE 4.5 +184.1 184088 1 ZSCAN4 NEK11 ASTE1 LOC105374108 GSTO3P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ASTE1 on UCSC Golden Path with GeneCards custom track

Promoters for ASTE1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000158419 949 1401 HDGF ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 ZNF143 SP3

Genomic Locations for ASTE1 Gene

Genomic Locations for ASTE1 Gene
13,777 bases
Minus strand

Genomic View for ASTE1 Gene

Genes around ASTE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASTE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASTE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASTE1 Gene

Proteins for ASTE1 Gene

  • Protein details for ASTE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein asteroid homolog 1
    Protein Accession:
    Secondary Accessions:
    • B4DFL9
    • Q3MIB6
    • Q8N6G4
    • Q96JY1
    • Q9UHX6

    Protein attributes for ASTE1 Gene

    679 amino acids
    Molecular mass:
    77093 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF14876.1; Type=Frameshift; Positions=336; Evidence={ECO:0000305}; Sequence=AAH30274.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI03710.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ASTE1 Gene


neXtProt entry for ASTE1 Gene

Post-translational modifications for ASTE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ASTE1 Gene

Domains & Families for ASTE1 Gene

Gene Families for ASTE1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ASTE1 Gene

Suggested Antigen Peptide Sequences for ASTE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the asteroid family.
  • Belongs to the asteroid family.
genes like me logo Genes that share domains with ASTE1: view

Function for ASTE1 Gene

Molecular function for ASTE1 Gene

UniProtKB/Swiss-Prot Function:
Possible role in EGF receptor signaling.

Gene Ontology (GO) - Molecular Function for ASTE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004518 nuclease activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ASTE1: view
genes like me logo Genes that share phenotypes with ASTE1: view

Animal Models for ASTE1 Gene

MGI Knock Outs for ASTE1:

Animal Model Products

miRNA for ASTE1 Gene

miRTarBase miRNAs that target ASTE1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ASTE1 Gene

Localization for ASTE1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ASTE1 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ASTE1 Gene

Pathways & Interactions for ASTE1 Gene

SuperPathways for ASTE1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ASTE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with ASTE1: view

No data available for Pathways by source and SIGNOR curated interactions for ASTE1 Gene

Drugs & Compounds for ASTE1 Gene

No Compound Related Data Available

Transcripts for ASTE1 Gene

Unigene Clusters for ASTE1 Gene

Asteroid homolog 1 (Drosophila):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ASTE1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10
SP1: - -
SP2: - - - -
SP4: - -
SP5: -
SP6: - - - -

Relevant External Links for ASTE1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ASTE1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ASTE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ASTE1 Gene

This gene is overexpressed in Lung (67.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ASTE1 Gene

Protein tissue co-expression partners for ASTE1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ASTE1 Gene:


SOURCE GeneReport for Unigene cluster for ASTE1 Gene:


Evidence on tissue expression from TISSUES for ASTE1 Gene

  • Nervous system(4.3)
  • Lung(4.1)
  • Skin(4.1)
genes like me logo Genes that share expression patterns with ASTE1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ASTE1 Gene

Orthologs for ASTE1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ASTE1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ASTE1 33 34
  • 99.75 (n)
(Canis familiaris)
Mammalia ASTE1 33 34
  • 90.43 (n)
(Rattus norvegicus)
Mammalia Aste1 33
  • 84.25 (n)
(Mus musculus)
Mammalia Aste1 33 16 34
  • 83.26 (n)
(Bos Taurus)
Mammalia ASTE1 33 34
  • 82.78 (n)
(Ornithorhynchus anatinus)
Mammalia ASTE1 34
  • 66 (a)
(Monodelphis domestica)
Mammalia ASTE1 34
  • 63 (a)
(Gallus gallus)
Aves ASTE1 33 34
  • 51.09 (n)
(Anolis carolinensis)
Reptilia ASTE1 34
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia aste1 33
  • 57.38 (n)
(Danio rerio)
Actinopterygii LOC100003699 33
  • 49.24 (n)
CABZ01002626.1 34
  • 40 (a)
aste1 34
  • 33 (a)
fruit fly
(Drosophila melanogaster)
Insecta ast 34
  • 19 (a)
Species where no ortholog for ASTE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ASTE1 Gene

Gene Tree for ASTE1 (if available)
Gene Tree for ASTE1 (if available)

Paralogs for ASTE1 Gene

No data available for Paralogs for ASTE1 Gene

Variants for ASTE1 Gene

Sequence variations from dbSNP and Humsavar for ASTE1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000438403 -- 131,018,166(+) AACTG(C/G)ATAGG intron-variant
rs1000612831 -- 131,017,599(+) CACTG(-/AGGTATTA)AAGTA intron-variant
rs1000684954 -- 131,017,924(+) AAGAT(A/T)GCACC intron-variant
rs1000723679 -- 131,016,876(+) AATCC(C/T)AGGAA intron-variant, downstream-variant-500B
rs1000776319 -- 131,016,580(+) AATAA(A/G)ATCTT intron-variant, utr-variant-3-prime

Variation tolerance for ASTE1 Gene

Residual Variation Intolerance Score: 74.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.57; 30.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ASTE1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ASTE1 Gene

Disorders for ASTE1 Gene

Relevant External Links for ASTE1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ASTE1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASTE1 Gene

Publications for ASTE1 Gene

  1. Overlapping ATP2C1 and ASTE1 genes in human genome: implications for SPCA1 expression? (PMID: 23344038) Micaroni M … Malquori L (International journal of molecular sciences 2013) 2 3 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60

Products for ASTE1 Gene

Sources for ASTE1 Gene

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