Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ASTE1 Gene

Aliases for ASTE1 Gene

  • Asteroid Homolog 1 (Drosophila) 2 3
  • Protein Asteroid Homolog 1 3
  • HT001 3

External Ids for ASTE1 Gene

Summaries for ASTE1 Gene

GeneCards Summary for ASTE1 Gene

ASTE1 (Asteroid Homolog 1 (Drosophila)) is a Protein Coding gene. Diseases associated with ASTE1 include hailey-hailey disease. GO annotations related to this gene include nuclease activity.

UniProtKB/Swiss-Prot for ASTE1 Gene

  • Possible role in EGF receptor signaling.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASTE1 Gene

Genomics for ASTE1 Gene

Genomic Location for ASTE1 Gene

Start:
131,013,873 bp from pter
End:
131,027,649 bp from pter
Size:
13,777 bases
Orientation:
Minus strand

Genomic View for ASTE1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ASTE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASTE1 Gene

Regulatory Elements for ASTE1 Gene

Proteins for ASTE1 Gene

  • Protein details for ASTE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2TB18-ASTE1_HUMAN
    Recommended name:
    Protein asteroid homolog 1
    Protein Accession:
    Q2TB18
    Secondary Accessions:
    • B4DFL9
    • Q3MIB6
    • Q8N6G4
    • Q96JY1
    • Q9UHX6

    Protein attributes for ASTE1 Gene

    Size:
    679 amino acids
    Molecular mass:
    77093 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF14876.1; Type=Frameshift; Positions=336; Evidence={ECO:0000305}; Sequence=AAH30274.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI03710.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ASTE1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASTE1 Gene

Proteomics data for ASTE1 Gene at MOPED

Post-translational modifications for ASTE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ASTE1 Gene

Domains for ASTE1 Gene

Protein Domains for ASTE1 Gene

UniProtKB/Swiss-Prot:

ASTE1_HUMAN
Family:
  • Belongs to the asteroid family.:
    • Q2TB18
genes like me logo Genes that share domains with ASTE1: view

No data available for Gene Families for ASTE1 Gene

Function for ASTE1 Gene

Molecular function for ASTE1 Gene

UniProtKB/Swiss-Prot Function: Possible role in EGF receptor signaling.

Gene Ontology (GO) - Molecular Function for ASTE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004518 nuclease activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ASTE1: view

Phenotypes for ASTE1 Gene

MGI mutant phenotypes for ASTE1:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with ASTE1: view

miRNA for ASTE1 Gene

miRTarBase miRNAs that target ASTE1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ASTE1 Gene

Localization for ASTE1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ASTE1 Gene COMPARTMENTS Subcellular localization image for ASTE1 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for ASTE1 Gene

Pathways for ASTE1 Gene

SuperPathways for ASTE1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ASTE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with ASTE1: view

No data available for Pathways by source for ASTE1 Gene

Transcripts for ASTE1 Gene

Unigene Clusters for ASTE1 Gene

Asteroid homolog 1 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ASTE1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10
SP1: - -
SP2: - - - -
SP3:
SP4: - -
SP5: -
SP6: - - - -
SP7:

Relevant External Links for ASTE1 Gene

GeneLoc Exon Structure for
ASTE1
ECgene alternative splicing isoforms for
ASTE1

Expression for ASTE1 Gene

mRNA expression in normal human tissues for ASTE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ASTE1 Gene

SOURCE GeneReport for Unigene cluster for ASTE1 Gene Hs.100878

genes like me logo Genes that share expressions with ASTE1: view

Orthologs for ASTE1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ASTE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ASTE1 36
  • 99.75 (n)
  • 99.85 (a)
ASTE1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ASTE1 36
  • 82.78 (n)
  • 79.49 (a)
ASTE1 37
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ASTE1 36
  • 90.43 (n)
  • 90.5 (a)
ASTE1 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aste1 36
  • 83.26 (n)
  • 79.14 (a)
Aste1 16
Aste1 37
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ASTE1 37
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ASTE1 37
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aste1 36
  • 84.25 (n)
  • 80.18 (a)
chicken
(Gallus gallus)
Aves ASTE1 36
  • 51.09 (n)
  • 44.61 (a)
ASTE1 37
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ASTE1 37
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia aste1 36
  • 57.38 (n)
  • 50.84 (a)
zebrafish
(Danio rerio)
Actinopterygii aste1 37
  • 33 (a)
OneToMany
CABZ01002626.1 37
  • 40 (a)
OneToMany
LOC100003699 36
  • 49.24 (n)
  • 40.48 (a)
fruit fly
(Drosophila melanogaster)
Insecta ast 37
  • 19 (a)
OneToOne
Species with no ortholog for ASTE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ASTE1 Gene

ENSEMBL:
Gene Tree for ASTE1 (if available)
TreeFam:
Gene Tree for ASTE1 (if available)

Paralogs for ASTE1 Gene

No data available for Paralogs for ASTE1 Gene

Variants for ASTE1 Gene

Sequence variations from dbSNP and Humsavar for ASTE1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs218501 -- 131,020,135(-) TGCAG(A/G)GCGGA intron-variant
rs218502 -- 131,019,632(-) CTTTT(C/G)TTTTT intron-variant
rs218503 -- 131,018,788(-) CTTCA(C/T)GCTAT intron-variant
rs218504 -- 131,017,601(-) AATAC(C/T)TCAGT intron-variant
rs1466702 -- 131,021,856(-) TTTTT(A/T)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ASTE1 Gene

Variant ID Type Subtype PubMed ID
nsv877498 CNV Gain 21882294

Relevant External Links for ASTE1 Gene

HapMap Linkage Disequilibrium report
ASTE1

Disorders for ASTE1 Gene

(1) MalaCards Diseases for ASTE1 Gene

Search for ASTE1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ASTE1 Gene

genes like me logo Genes that share disorders with ASTE1: view

No data available for UniProtKB/Swiss-Prot for ASTE1 Gene

Publications for ASTE1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Tumor-infiltrating lymphocytes in colorectal cancers with microsatellite instability are correlated with the number and spectrum of frameshift mutations. (PMID: 19503063) Tougeron D. … Latouche J.B. (Mod. Pathol. 2009) 3
  3. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PMID: 24163370) Lu L. … Zhang L. (J. Biol. Chem. 2013) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 4

Products for ASTE1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ASTE1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ASTE1
    • Block miRNA regulation of ASTE1 using miScript Target Protectors

    Sources for ASTE1 Gene

    Back to Top

    Content