ASTE1 Gene
protein-coding GIFtS: 43
GCID: GC03M130732
|
|
asteroid homolog 1 (Drosophila)
| |
Aliases
for ASTE1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Asteroid Homolog 1 (Drosophila)1 2 | | HT0011 | | Protein Asteroid Homolog 12 |
Export aliases for ASTE1 gene to outside databasesPrevious GC identifers: GC03M132216 GC03M128116 |
Summaries
for ASTE1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ASTE1_HUMAN, Q2TB18Function: Possible role in EGF receptor signaling (By similarity)
|
Genomic Views
for ASTE1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ASTE1 gene promoter:
SRF C/EBPbeta ATF-2 Nkx2-5 LCR-F1 HNF-1A GATA-2 CRE-BP1 HNF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ASTE1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASTE1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q22.1 Ensembl cytogenetic band: 3q22.1 HGNC cytogenetic band: 3q21.3ASTE1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M130732: view genomic region
(about GC identifiers)
Start:
|
130,732,719 bp from pter |
End:
|
130,746,493 bp from pter |
Size:
|
13,775 bases |
Orientation:
|
minus strand |
|
Proteins
for ASTE1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ASTE1_HUMAN, Q2TB18 (See
protein sequence)Recommended Name: Protein asteroid homolog 1 Size: 679 amino acids; 77093 Da
Sequence caution: Sequence=AAF14876.1; Type=Frameshift; Positions=336; Sequence=AAH30274.2; Type=Erroneous initiation;Sequence=AAI03710.1; Type=Erroneous initiation;
Secondary accessions: Q3MIB6 Q8N6G4 Q96JY1 Q9UHX6Explore the universe of human proteins at neXtProt for ASTE1: NX_Q2TB18
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q2TB18
ASTE1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_054784.2
ENSEMBL proteins: ENSP00000426421 ENSP00000264992 ENSP00000421019 ENSP00000423347 ENSP00000426363 ENSP00000425683 ENSP00000422851 ENSP00000427303
Human Recombinant Protein Products for ASTE1:
ASTE1 Antibody Products:
Assay Products for ASTE1: |
Protein
Domains /
Families
for ASTE1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ASTE1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q2TB18ProtoNet protein and cluster: Q2TB18 UniProtKB/Swiss-Prot: ASTE1_HUMAN, Q2TB18Similarity: Belongs to the asteroid family |
Function
for ASTE1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ASTE1_HUMAN, Q2TB18Function: Possible role in EGF receptor signaling (By similarity) Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004518 | nuclease activity |
IEA | -- |
ASTE1 for ontologies About GeneDecksing
Phenotypes:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Aste1):
ASTE1 for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASTE1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASTE1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ASTE1 (NM_014065) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ASTE1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASTE1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASTE1 |
|
Pathways & Interactions
for ASTE1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ASTE1
1 Interacting protein for ASTE1 (Q2TB183) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006281 | DNA repair |
IEA | -- |
ASTE1 for ontologies About GeneDecksing
|
Drugs & Compounds
for ASTE1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ASTE1
Search CenterWatch for drugs/clinical trials and news about ASTE1
|
Transcripts
for ASTE1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ASTE1 gene: NM_014065.2 Unigene Cluster for ASTE1: Asteroid homolog 1 (Drosophila) Hs.100878 [show with all ESTs]Unigene Representative Sequence: AK2941568 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000514044(uc010htm.1) ENST00000264992(uc003env.1 uc011blj.1)
ENST00000507978 ENST00000505290 ENST00000504964 ENST00000505545 ENST00000504725
ENST00000509060
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASTE1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASTE1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ASTE1 (NM_014065) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ASTE1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASTE1 |
Additional cDNA sequence: AF113539.1 AK027258.1 AK027806.1 AK294156.1 AK301388.1 BC030274.1 BC069265.1 BC103709.1 BC110616.2 10 DOTS entries: DT.443998 DT.120871848 DT.92446986 DT.100754523 DT.100688106 DT.120871865 DT.95156684 DT.120871896 DT.95107438 DT.97805368 24/78 AceView cDNA sequences (see all 78): BX507326 AI017204 AI374771 AA361773 AK027806 NM_014065 AW450093 AA453645 BC069265 BM720591 BX281662 AA668674 AW182623 N46587 BQ923541 AA454228 AA972721 AA648895 AA426141 AA345255 N58008 AA768532 BM992874 AA767173
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ASTE1 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ASTE1
|
Expression
for ASTE1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ASTE1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGCAACCAA
About this image
See ASTE1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ASTE1
SOURCE GeneReport for Unigene cluster: Hs.100878
SABiosciences Custom PCR Arrays for ASTE1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ASTE1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ASTE1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ASTE1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASTE1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASTE1 |
Orthologs
for ASTE1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ASTE1 gene from 5/13 species (see all 13) About this table
ENSEMBL Gene Tree for ASTE1 (if available)
TreeFam Gene Tree for ASTE1 (if available) |
Paralogs
for ASTE1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for ASTE1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ASTE1 (130732719 - 130746493 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ASTE1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ASTE1 |
|
Disorders
/ Diseases
for ASTE1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ASTE1 for disorders About GeneDecksing
1  disease for ASTE1: About MalaCardscolorectal cancer
1 disease from the University of Copenhagen DISEASES database for ASTE1:Hailey-Hailey disease Export disorders for ASTE1 gene to outside databases
|
Publications
for ASTE1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ASTE1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ASTE1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Tumor-infiltrating lymphocytes in colorectal cancers with microsatellite instability are correlated with the number and spectrum of frameshift mutations. (PubMed id 19503063)1 Tougeron D....Latouche J.B. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)2 Hu R.-M.... Chen J.-L. (2000)
|
External Searches for ASTE1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ASTE1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ASTE1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ASTE1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for ASTE1 gene:
Search GeneIP for patents involving ASTE1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ASTE1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ASTE1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ASTE1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ASTE1 | | | OriGene Protein Over-expression Lysate for ASTE1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for ASTE1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASTE1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASTE1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ASTE1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ASTE1 | | OriGene Custom Protein Services for ASTE1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ASTE1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ASTE1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASTE1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ASTE1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASTE1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ASTE1 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for ASTE1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | ASTE1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASTE1 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for ASTE1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASTE1 |
| |  | |
|
|
|
