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Aliases for ASTE1 Gene

Aliases for ASTE1 Gene

  • Asteroid Homolog 1 (Drosophila) 2 3
  • HT001 3

External Ids for ASTE1 Gene

Previous GeneCards Identifiers for ASTE1 Gene

  • GC03M132216
  • GC03M130732
  • GC03M128116

Summaries for ASTE1 Gene

GeneCards Summary for ASTE1 Gene

ASTE1 (Asteroid Homolog 1 (Drosophila)) is a Protein Coding gene. GO annotations related to this gene include nuclease activity.

UniProtKB/Swiss-Prot for ASTE1 Gene

  • Possible role in EGF receptor signaling.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASTE1 Gene

Genomics for ASTE1 Gene

Regulatory Elements for ASTE1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ASTE1 Gene

131,013,873 bp from pter
131,027,649 bp from pter
13,777 bases
Minus strand

Genomic View for ASTE1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ASTE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASTE1 Gene

Proteins for ASTE1 Gene

  • Protein details for ASTE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein asteroid homolog 1
    Protein Accession:
    Secondary Accessions:
    • B4DFL9
    • Q3MIB6
    • Q8N6G4
    • Q96JY1
    • Q9UHX6

    Protein attributes for ASTE1 Gene

    679 amino acids
    Molecular mass:
    77093 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF14876.1; Type=Frameshift; Positions=336; Evidence={ECO:0000305}; Sequence=AAH30274.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI03710.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ASTE1 Gene


neXtProt entry for ASTE1 Gene

Proteomics data for ASTE1 Gene at MOPED

Post-translational modifications for ASTE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ASTE1 Gene

Domains & Families for ASTE1 Gene

Protein Domains for ASTE1 Gene

Suggested Antigen Peptide Sequences for ASTE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the asteroid family.
  • Belongs to the asteroid family.
genes like me logo Genes that share domains with ASTE1: view

No data available for Gene Families for ASTE1 Gene

Function for ASTE1 Gene

Molecular function for ASTE1 Gene

UniProtKB/Swiss-Prot Function:
Possible role in EGF receptor signaling.

Gene Ontology (GO) - Molecular Function for ASTE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004518 nuclease activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ASTE1: view

Phenotypes for ASTE1 Gene

MGI mutant phenotypes for ASTE1:
inferred from 1 alleles
GenomeRNAi human phenotypes for ASTE1:
genes like me logo Genes that share phenotypes with ASTE1: view

Animal Model Products

miRNA for ASTE1 Gene

miRTarBase miRNAs that target ASTE1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ASTE1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ASTE1 Gene

Localization for ASTE1 Gene

Subcellular locations from

Jensen Localization Image for ASTE1 Gene COMPARTMENTS Subcellular localization image for ASTE1 gene
Compartment Confidence
endoplasmic reticulum 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ASTE1 Gene

Pathways & Interactions for ASTE1 Gene

SuperPathways for ASTE1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ASTE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with ASTE1: view

No data available for Pathways by source and SIGNOR curated interactions for ASTE1 Gene

Drugs & Compounds for ASTE1 Gene

No Compound Related Data Available

Transcripts for ASTE1 Gene

Unigene Clusters for ASTE1 Gene

Asteroid homolog 1 (Drosophila):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ASTE1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ASTE1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10
SP1: - -
SP2: - - - -
SP4: - -
SP5: -
SP6: - - - -

Relevant External Links for ASTE1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ASTE1 Gene

mRNA expression in normal human tissues for ASTE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ASTE1 Gene

This gene is overexpressed in Lung (67.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ASTE1 Gene

SOURCE GeneReport for Unigene cluster for ASTE1 Gene Hs.100878

genes like me logo Genes that share expression patterns with ASTE1: view

Protein tissue co-expression partners for ASTE1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ASTE1 Gene

Orthologs for ASTE1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ASTE1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ASTE1 35
  • 82.78 (n)
  • 79.49 (a)
ASTE1 36
  • 79 (a)
(Canis familiaris)
Mammalia ASTE1 35
  • 90.43 (n)
  • 90.5 (a)
ASTE1 36
  • 89 (a)
(Mus musculus)
Mammalia Aste1 35
  • 83.26 (n)
  • 79.14 (a)
Aste1 16
Aste1 36
  • 79 (a)
(Pan troglodytes)
Mammalia ASTE1 35
  • 99.75 (n)
  • 99.85 (a)
ASTE1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Aste1 35
  • 84.25 (n)
  • 80.18 (a)
(Monodelphis domestica)
Mammalia ASTE1 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia ASTE1 36
  • 66 (a)
(Gallus gallus)
Aves ASTE1 35
  • 51.09 (n)
  • 44.61 (a)
ASTE1 36
  • 45 (a)
(Anolis carolinensis)
Reptilia ASTE1 36
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia aste1 35
  • 57.38 (n)
  • 50.84 (a)
(Danio rerio)
Actinopterygii LOC100003699 35
  • 49.24 (n)
  • 40.48 (a)
aste1 36
  • 33 (a)
CABZ01002626.1 36
  • 40 (a)
fruit fly
(Drosophila melanogaster)
Insecta ast 36
  • 19 (a)
Species with no ortholog for ASTE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ASTE1 Gene

Gene Tree for ASTE1 (if available)
Gene Tree for ASTE1 (if available)

Paralogs for ASTE1 Gene

No data available for Paralogs for ASTE1 Gene

Variants for ASTE1 Gene

Sequence variations from dbSNP and Humsavar for ASTE1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs218501 -- 131,020,135(-) TGCAG(A/G)GCGGA intron-variant
rs218502 -- 131,019,632(-) CTTTT(C/G)TTTTT intron-variant
rs218503 -- 131,018,788(-) CTTCA(C/T)GCTAT intron-variant
rs218504 -- 131,017,601(-) AATAC(C/T)TCAGT intron-variant
rs1466702 -- 131,021,856(-) TTTTT(A/T)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ASTE1 Gene

Variant ID Type Subtype PubMed ID
nsv877498 CNV Gain 21882294

Variation tolerance for ASTE1 Gene

Residual Variation Intolerance Score: 74.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.57; 30.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ASTE1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASTE1 Gene

Disorders for ASTE1 Gene

Relevant External Links for ASTE1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ASTE1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASTE1 Gene

Publications for ASTE1 Gene

  1. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  2. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PMID: 24163370) Lu L. … Zhang L. (J. Biol. Chem. 2013) 67
  3. Overlapping ATP2C1 and ASTE1 genes in human genome: implications for SPCA1 expression? (PMID: 23344038) Micaroni M. … Malquori L. (Int J Mol Sci 2013) 67
  4. Tumor-infiltrating lymphocytes in colorectal cancers with microsatellite instability are correlated with the number and spectrum of frameshift mutations. (PMID: 19503063) Tougeron D. … Latouche J.B. (Mod. Pathol. 2009) 67
  5. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 67

Products for ASTE1 Gene

Sources for ASTE1 Gene

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