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Aliases for ASRGL1 Gene

Aliases for ASRGL1 Gene

  • Asparaginase Like 1 2 3 5
  • Asparaginase-Like 1 Protein 2 3
  • Asparaginase-Like Protein 1 3 4
  • L-Asparagine Amidohydrolase 3 4
  • Isoaspartyl Dipeptidase 3 4
  • Beta-Aspartyl-Peptidase 3 4
  • EC 3.5.1.1 4 61
  • CRASH 3 4
  • ALP 3 4
  • Testis Secretory Sperm-Binding Protein Li 242mP 3
  • Isoaspartyl Peptidase/L-Asparaginase 3
  • L-Asparaginase 3
  • EC 3.4.19.5 4
  • ALP1 3

External Ids for ASRGL1 Gene

Previous GeneCards Identifiers for ASRGL1 Gene

  • GC00U991098
  • GC11P063680
  • GC11P061880
  • GC11P061861
  • GC11P062104
  • GC11P058433

Summaries for ASRGL1 Gene

GeneCards Summary for ASRGL1 Gene

ASRGL1 (Asparaginase Like 1) is a Protein Coding gene. Among its related pathways are Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism and asparagine degradation. GO annotations related to this gene include hydrolase activity and asparaginase activity. An important paralog of this gene is TASP1.

UniProtKB/Swiss-Prot for ASRGL1 Gene

  • Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine.

Gene Wiki entry for ASRGL1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASRGL1 Gene

Genomics for ASRGL1 Gene

Regulatory Elements for ASRGL1 Gene

Enhancers for ASRGL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ASRGL1 on UCSC Golden Path with GeneCards custom track

Promoters for ASRGL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ASRGL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ASRGL1 Gene

Chromosome:
11
Start:
62,337,302 bp from pter
End:
62,401,378 bp from pter
Size:
64,077 bases
Orientation:
Plus strand

Genomic View for ASRGL1 Gene

Genes around ASRGL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASRGL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASRGL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASRGL1 Gene

Proteins for ASRGL1 Gene

  • Protein details for ASRGL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L266-ASGL1_HUMAN
    Recommended name:
    Isoaspartyl peptidase/L-asparaginase
    Protein Accession:
    Q7L266
    Secondary Accessions:
    • B2R7Q0
    • Q567Q4
    • Q6P1P0
    • Q8NI34
    • Q9H6F7

    Protein attributes for ASRGL1 Gene

    Size:
    308 amino acids
    Molecular mass:
    32055 Da
    Quaternary structure:
    • Heterodimer of an alpha and beta chain produced by autocleavage. This heterodimer may then dimerize in turn, giving rise to a heterotetramer.
    SequenceCaution:
    • Sequence=BAB15302.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15302.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ASRGL1 Gene

    Alternative splice isoforms for ASRGL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASRGL1 Gene

Selected DME Specific Peptides for ASRGL1 Gene

Post-translational modifications for ASRGL1 Gene

  • Cleaved into an alpha and beta chain by autocatalysis; this activates the enzyme. The N-terminal residue of the beta subunit is responsible for the nucleophile hydrolase activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for ASRGL1 Gene

Protein Domains for ASRGL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q7L266

UniProtKB/Swiss-Prot:

ASGL1_HUMAN :
  • Belongs to the Ntn-hydrolase family.
Family:
  • Belongs to the Ntn-hydrolase family.
genes like me logo Genes that share domains with ASRGL1: view

No data available for Gene Families for ASRGL1 Gene

Function for ASRGL1 Gene

Molecular function for ASRGL1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=3.4 mM for L-asparagine (L-Asn) {ECO:0000269 PubMed:19839645}; KM=0.4 mM for L-aspartic acid beta-methyl ester {ECO:0000269 PubMed:19839645}; KM=0.4 mM for L-Asp-L-Phe {ECO:0000269 PubMed:19839645}; KM=1.0 mM for L-Asp-L-Ala {ECO:0000269 PubMed:19839645};
UniProtKB/Swiss-Prot CatalyticActivity:
L-asparagine + H(2)O = L-aspartate + NH(3).
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of a beta-linked Asp residue from the N-terminus of a polypeptide.
UniProtKB/Swiss-Prot EnzymeRegulation:
Glycine accelerates autocleavage into an alpha and beta chain.
UniProtKB/Swiss-Prot Function:
Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine.
UniProtKB/Swiss-Prot Induction:
By 5-alpha-di-hydrotestosterone and progesterone.

Enzyme Numbers (IUBMB) for ASRGL1 Gene

Gene Ontology (GO) - Molecular Function for ASRGL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003948 NOT N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity IDA 19839645
GO:0004067 asparaginase activity IDA 19839645
GO:0008798 beta-aspartyl-peptidase activity TAS --
genes like me logo Genes that share ontologies with ASRGL1: view
genes like me logo Genes that share phenotypes with ASRGL1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ASRGL1

CRISPR Products

miRNA for ASRGL1 Gene

miRTarBase miRNAs that target ASRGL1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ASRGL1 Gene

Localization for ASRGL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ASRGL1 Gene

Cytoplasm. Note=Midpiece of sperm tail.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ASRGL1 Gene COMPARTMENTS Subcellular localization image for ASRGL1 gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ASRGL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ASRGL1: view

Pathways & Interactions for ASRGL1 Gene

genes like me logo Genes that share pathways with ASRGL1: view

Gene Ontology (GO) - Biological Process for ASRGL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006559 L-phenylalanine catabolic process TAS --
GO:0033345 asparagine catabolic process via L-aspartate ISS --
genes like me logo Genes that share ontologies with ASRGL1: view

No data available for SIGNOR curated interactions for ASRGL1 Gene

Drugs & Compounds for ASRGL1 Gene

(4) Drugs for ASRGL1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Asparagine Approved Nutra Target 0
L-Aspartic acid Approved Nutra Target 0
Water Approved Pharma 0

(4) Additional Compounds for ASRGL1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ammonia
  • Ammonia anhydrous
  • Ammonia inhalant
  • Ammonia solution strong [usan]
  • Ammonia water
  • Ammoniak
7664-41-7
genes like me logo Genes that share compounds with ASRGL1: view

Transcripts for ASRGL1 Gene

Unigene Clusters for ASRGL1 Gene

Asparaginase like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ASRGL1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b
SP1: - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - -
SP5: - - - -
SP6: -
SP7: -
SP8:

Relevant External Links for ASRGL1 Gene

GeneLoc Exon Structure for
ASRGL1
ECgene alternative splicing isoforms for
ASRGL1

Expression for ASRGL1 Gene

mRNA expression in normal human tissues for ASRGL1 Gene

mRNA differential expression in normal tissues according to GTEx for ASRGL1 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x4.4).

Protein differential expression in normal tissues from HIPED for ASRGL1 Gene

This gene is overexpressed in Liver (25.2) and Ovary (18.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ASRGL1 Gene



NURSA nuclear receptor signaling pathways regulating expression of ASRGL1 Gene:

ASRGL1

SOURCE GeneReport for Unigene cluster for ASRGL1 Gene:

Hs.535326

mRNA Expression by UniProt/SwissProt for ASRGL1 Gene:

Q7L266-ASGL1_HUMAN
Tissue specificity: Expressed in brain, kidney, testis and tissues of the gastrointestinal tract. Present in sperm (at protein level). Over-expressed in uterine, mammary, prostatic and ovarian carcinoma.
genes like me logo Genes that share expression patterns with ASRGL1: view

Primer Products

No data available for Protein tissue co-expression partners for ASRGL1 Gene

Orthologs for ASRGL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ASRGL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ASRGL1 34
  • 82.3 (n)
  • 82.41 (a)
ASRGL1 35
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ASRGL1 34
  • 83.23 (n)
  • 83.12 (a)
ASRGL1 35
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Asrgl1 34
  • 79.56 (n)
  • 78.36 (a)
Asrgl1 16
Asrgl1 35
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ASRGL1 34
  • 99.24 (n)
  • 98.38 (a)
ASRGL1 35
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Asrgl1 34
  • 78.58 (n)
  • 77.7 (a)
oppossum
(Monodelphis domestica)
Mammalia ASRGL1 35
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ASRGL1 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves ASRGL1 34
  • 67.34 (n)
  • 66.44 (a)
ASRGL1 35
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ASRGL1 35
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii asrgl1 34
  • 61.24 (n)
  • 62.71 (a)
asrgl1 35
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7860 35
  • 39 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G16150 34
  • 49.6 (n)
  • 45.33 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6054 34
Species where no ortholog for ASRGL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ASRGL1 Gene

ENSEMBL:
Gene Tree for ASRGL1 (if available)
TreeFam:
Gene Tree for ASRGL1 (if available)

Paralogs for ASRGL1 Gene

Paralogs for ASRGL1 Gene

(1) SIMAP similar genes for ASRGL1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ASRGL1: view

Variants for ASRGL1 Gene

Sequence variations from dbSNP and Humsavar for ASRGL1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1043785 -- 62,393,251(+) TTCCT(C/T)GGTGG intron-variant, utr-variant-3-prime
rs1043789 -- 62,393,257(+) GGTGG(A/G)CAGTA intron-variant, utr-variant-3-prime
rs7943362 -- 62,364,953(+) aatcc(C/T)agcta intron-variant
rs7947190 -- 62,349,030(+) gtggc(A/G)cgatc intron-variant
rs7948891 -- 62,370,816(+) tttcc(G/T)tgggg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ASRGL1 Gene

Variant ID Type Subtype PubMed ID
dgv202e214 CNV loss 21293372
dgv218e199 CNV deletion 23128226
esv1580794 CNV insertion 17803354
esv3408585 CNV insertion 20981092
esv3626599 CNV gain 21293372
esv3626600 CNV gain 21293372
esv3626603 CNV gain 21293372
esv3626604 CNV loss 21293372
nsv1039105 CNV gain 25217958
nsv1053587 CNV gain 25217958
nsv468586 CNV loss 19166990
nsv516460 CNV gain 19592680
nsv555172 CNV loss 21841781
nsv555173 CNV loss 21841781
nsv983031 CNV duplication 23825009

Variation tolerance for ASRGL1 Gene

Residual Variation Intolerance Score: 47.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.20; 24.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ASRGL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ASRGL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASRGL1 Gene

Disorders for ASRGL1 Gene

Relevant External Links for ASRGL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ASRGL1

No disorders were found for ASRGL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASRGL1 Gene

Publications for ASRGL1 Gene

  1. The human asparaginase-like protein 1 hASRGL1 is an Ntn hydrolase with beta-aspartyl peptidase activity. (PMID: 19839645) Cantor J.R. … Georgiou G. (Biochemistry 2009) 3 4 22 65
  2. A novel asparaginase-like protein is a sperm autoantigen in rats. (PMID: 11984834) Bush L.A. … Flickinger C.J. (Mol. Reprod. Dev. 2002) 3 4 22 65
  3. Uncoupling intramolecular processing and substrate hydrolysis in the N-terminal nucleophile hydrolase hASRGL1 by circular permutation. (PMID: 22891768) Li W. … Zhang Y. (ACS Chem. Biol. 2012) 3 4 65
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  5. Intramolecular Cleavage of the hASRGL1 Homodimer Occurs in Two Stages. (PMID: 26780688) Li W. … Stone E. (Biochemistry 2016) 3 65

Products for ASRGL1 Gene

Sources for ASRGL1 Gene

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