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ASRGL1 Gene

protein-coding   GIFtS: 59
GCID: GC11P062104

Asparaginase Like 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Asparaginase Like 11 2     EC 3.5.1.13 8
Asparaginase-Like 1 Protein1 2     ALP12
Asparaginase-Like Protein 12 3     L-asparaginase2
Isoaspartyl Dipeptidase2 3     beta-aspartyl-peptidase2
ALP2 3     Isoaspartyl Peptidase/L-Asparaginase2
CRASH2 3     Beta-aspartyl-peptidase3
L-Asparagine Amidohydrolase2 3     EC 3.4.19.53

External Ids:    HGNC: 164481   Entrez Gene: 801502   Ensembl: ENSG000001621747   OMIM: 6092125   UniProtKB: Q7L2663   

Export aliases for ASRGL1 gene to outside databases

Previous GC identifers: GC00U991098 GC11P063680 GC11P062355 GC11P061880 GC11P061861 GC11P058433


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ASRGL1 Gene:
ASRGL1 (asparaginase like 1) is a protein-coding gene. Diseases associated with ASRGL1 include telogen effluvium, and central nervous system leukemia. GO annotations related to this gene include beta-aspartyl-peptidase activity and N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity. An important paralog of this gene is AGA.

UniProtKB/Swiss-Prot: ASGL1_HUMAN, Q7L266
Function: Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of
L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp
beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters,
including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and
beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise,
has no activity toward glutamine

Gene Wiki entry for ASRGL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ASRGL1 gene promoter:
         STAT5B   STAT1   STAT4   STAT1beta   STAT6   STAT5A   STAT1alpha   STAT2   STAT3   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidASRGL1 promoter sequence
   Search Chromatin IP Primers for ASRGL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ASRGL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.3   Ensembl cytogenetic band:  11q12.3   HGNC cytogenetic band: 11q12.3

ASRGL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASRGL1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P062104:  view genomic region     (about GC identifiers)

Start:
62,104,774 bp from pter      End:
62,160,887 bp from pter
Size:
56,114 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ASGL1_HUMAN, Q7L266 (See protein sequence)
Recommended Name: Isoaspartyl peptidase/L-asparaginase precursor  
Size: 308 amino acids; 32055 Da
Subunit: Heterodimer of an alpha and beta chain produced by autocleavage. This heterodimer may then dimerize in
turn, giving rise to a heterotetramer
Sequence caution: Sequence=BAB15302.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB15302.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence;
Selected PDB 3D structures from and Proteopedia for ASRGL1 (see all 8):
3TKJ (3D)        4ET0 (3D)        4GDT (3D)        4GDU (3D)        4GDV (3D)        4GDW (3D)    
Secondary accessions: B2R7Q0 Q567Q4 Q6P1P0 Q8NI34 Q9H6F7
Alternative splicing: 2 isoforms:  Q7L266-1   Q7L266-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ASRGL1: NX_Q7L266

Explore proteomics data for ASRGL1 at MOPED

Post-translational modifications: 

  • Cleaved into an alpha and beta chain by autocatalysis; this activates the enzyme. The N-terminal residue of the
    beta subunit is responsible for the nucleophile hydrolase activity1
  • Modification sites at neXtProt
  • 2 DME Specific Peptides for ASRGL1 (Q7L266)
     NKMVGRVGD  STTGHGESILKVNLARL 


    See ASRGL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001077395.1  NP_079356.3  

    ENSEMBL proteins: 
     ENSP00000400057   ENSP00000431772   ENSP00000301776   ENSP00000433136   ENSP00000443284  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000246 Peptidase_T2

    Graphical View of Domain Structure for InterPro Entry Q7L266

    ProtoNet protein and cluster: Q7L266

    1 Blocks protein domain: IPB000246 Asparaginase 2 family

    UniProtKB/Swiss-Prot: ASGL1_HUMAN, Q7L266
    Similarity: Belongs to the Ntn-hydrolase family


    ASRGL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ASGL1_HUMAN, Q7L266
    Function: Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of
    L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp
    beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters,
    including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and
    beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise,
    has no activity toward glutamine
    Catalytic activity: L-asparagine + H(2)O = L-aspartate + NH(3)
    Catalytic activity: Cleavage of a beta-linked Asp residue from the N-terminus of a polypeptide
    Enzyme regulation: Glycine accelerates autocleavage into an alpha and beta chain
    Biophysicochemical properties: Kinetic parameters: KM=3.4 mM for L-asparagine (L-Asn); KM=0.4 mM for L-aspartic
    acid beta-methyl ester; KM=0.4 mM for L-Asp-L-Phe; KM=1.0 mM for L-Asp-L-Ala;
    Induction: By 5-alpha-di-hydrotestosterone and progesterone

         Enzyme Numbers (IUBMB): EC 3.5.1.11 2 EC 3.4.19.51

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003948NOT N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity IDA19839645
    GO:0004067asparaginase activity IDA19839645
    GO:0008798beta-aspartyl-peptidase activity IDA19839645
    GO:0016787hydrolase activity ----
         
    ASRGL1 for ontologies           About GeneDecksing


    Animal Models:
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    Selected qRT-PCR Assays for microRNAs that regulate ASRGL1 (see all 11):
    hsa-miR-607 hsa-miR-922 hsa-miR-196a* hsa-miR-3660 hsa-miR-3065-5p hsa-miR-520a-5p hsa-miR-621 hsa-miR-199a-5p
    SwitchGear 3'UTR luciferase reporter plasmidASRGL1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ASRGL1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ASGL1_HUMAN, Q7L266: Cytoplasm. Note=Midpiece of sperm tail
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    nucleus4
    cytosol2
    extracellular2
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm ISS--
    GO:0015630microtubule cytoskeleton ----

    ASRGL1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ASRGL1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1asparagine degradation I
    asparagine degradation I


    1 BioSystems Pathway for ASRGL1
        asparagine degradation I



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ASRGL1
    Interactions:

        Search GeneGlobe Interaction Network for ASRGL1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    Selected Interacting proteins for ASRGL1 (Q7L2662, 3 ENSP000003017764) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GSK3BP498412, 3MINT-8256877 I2D: score=2 
    MAPK8IP2Q133872, 3MINT-8262396 I2D: score=2 
    TAB1Q157502, 3MINT-8259998 I2D: score=2 
    MAP2K5Q131632, 3, ENSP000001786404MINT-8259855 I2D: score=2 STRING: ENSP00000178640
    RPS3P233963I2D: score=5 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0033345asparagine catabolic process via L-aspartate ISS--

    ASRGL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ASRGL1 (ASGL1)

    4 HMDB Compounds for ASRGL1    About this table
    CompoundSynonyms CAS #PubMed Ids
    AmmoniaNH3 (see all 31)7664-41-7--
    L-Asparagine(-)-Asparagine (see all 32)70-47-3--
    L-Aspartic acid(+)-Aspartate (see all 41)56-84-8--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 DrugBank Compounds for ASRGL1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Asparagine(-)-Asparagine (see all 15)70-47-3target--17139284 17016423
    L-Aspartic Acid(+)-Aspartic acid (see all 23)56-84-8target--17139284 17016423

    4 Novoseek inferred chemical compound relationships for ASRGL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sq 22536 71.3 2 12606604 (1), 14727527 (1)
    beraprost sodium 70.4 3 14727527 (2), 12606604 (1)
    prostacyclin 26.3 1 12606604 (1)
    adenylate 16.2 1 12606604 (1)



    ASRGL1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ASRGL1 gene (2 alternative transcripts): 
    NM_001083926.1  NM_025080.3  

    Unigene Cluster for ASRGL1:

    Asparaginase like 1
    Hs.535326  [show with all ESTs]
    Unigene Representative Sequence: BX640832
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000415229(uc001nte.4 uc001ntf.4 uc001ntg.4) ENST00000534183
    ENST00000301776 ENST00000525496 ENST00000529226 ENST00000534571 ENST00000526096
    ENST00000528206(uc001nth.1) ENST00000525708 ENST00000533970 ENST00000535727


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    hsa-miR-607 hsa-miR-922 hsa-miR-196a* hsa-miR-3660 hsa-miR-3065-5p hsa-miR-520a-5p hsa-miR-621 hsa-miR-199a-5p
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    Additional mRNA sequence: 

    AF411076.1 AK090908.1 AK091403.1 AK091894.1 AK225802.1 AK297158.1 AK309845.1 AK313069.1 
    BC006267.2 BC021295.2 BC064963.1 BC093070.1 BX640832.1 

    17 DOTS entries:

    DT.102831842  DT.100783188  DT.100028117  DT.100028119  DT.402167  DT.95247161  DT.92428247  DT.120716913 
    DT.120716927  DT.92428251  DT.95188695  DT.95247674  DT.99959575  DT.120716958  DT.65287104  DT.91861099 
    DT.92428248 

    Selected AceView cDNA sequences (see all 206):

    BE896604 AI962178 AI800322 AI208856 BU169415 CB116680 AI352590 AA931265 
    BU156650 AI811358 BM930627 AW440338 BF821810 BE783412 BU183811 AA476944 
    BC064963 AI961462 BQ425447 AA477368 CR620676 CR617167 BM465903 AA236726 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ASRGL1 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b
    SP1:                    -                 -                       -                 -                     
    SP2:                    -     -           -                       -                 -                     
    SP3:                    -     -           -     -                 -                 -                     
    SP4:                    -     -           -                                                               
    SP5:                    -                 -     -                 -                                       


    ECgene alternative splicing isoforms for ASRGL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ASRGL1 expression in normal human tissues (normalized intensities)      ASRGL1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCCGCTAAT
    ASRGL1 Expression
    About this image


    ASRGL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
             brain/forebrain/telencephalon   
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             Testis Interstitium
     
     Spinal Cord (Nervous System)
    ASRGL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ASRGL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.535326

    UniProtKB/Swiss-Prot: ASGL1_HUMAN, Q7L266
    Tissue specificity: Expressed in brain, kidney, testis and tissues of the gastrointestinal tract. Present in sperm
    (at protein level). Over-expressed in uterine, mammary, prostatic and ovarian carcinoma

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ASRGL1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Asrgl11 , 5 asparaginase like 11, 5 79.56(n)1
    78.36(a)1
      19 (6.06 cM)5
    665141  NM_025610.31  NP_079886.21 
     91098685 
    chicken
    (Gallus gallus)
    Aves ASRGL11 asparaginase like 1 67.34(n)
    66.44(a)
      421868  XM_419885.4  XP_419885.1 
    lizard
    (Anolis carolinensis)
    Reptilia ASRGL16
    asparaginase like 1
    63(a)
    1 ↔ 1
    1(168188001-168230317)
    African clawed frog
    (Xenopus laevis)
    Amphibia CF521899.12   -- 73.44(n)    CF521899.1 
    zebrafish
    (Danio rerio)
    Actinopterygii asrgl11 asparaginase like 1 61.24(n)
    62.71(a)
      541402  NM_001013529.1  NP_001013547.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG78606
    --
    39(a)
    1 ↔ 1
    X(15463026-15464474)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G161501 AT3G16150 49.6(n)
    45.33(a)
      820860  NM_112485.3  NP_566536.1 


    ENSEMBL Gene Tree for ASRGL1 (if available)
    TreeFam Gene Tree for ASRGL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ASRGL1 gene
    AGA2  TASP12  
    1 SIMAP similar gene for ASRGL1 using alignment to 4 protein entries:     ASGL1_HUMAN (see all proteins):
    TASP1

    ASRGL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ASRGL1 (see all 1286)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs734940081,2
    C,F--62102834(+) AAAGTC/ACACTT 2 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1420673611,2
    --62102862(+) GCTAGA/GGAGCT 2 -- us2k10--------
    rs793653621,2
    C--62102873(+) TTCCTA/GAATTA 2 -- us2k10--------
    rs1149683001,2
    C,F--62102959(+) GGTGCC/TTAGGA 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1394697721,2
    C--62103070(+) ATGTC-/TTGTTG
            
    TTGTT
    2 -- us2k10--------
    rs1460941551,2
    C--62103070(+) ATGTC-/TTGTTGTT 2 -- us2k10--------
    rs803110681,2
    --62103093(+) TTGTTA/GTTGTT 2 -- us2k10--------
    rs79287321,2
    C,F,A--62103096(+) TTGTTA/C/GTTATT 2 -- us2k13WA NA EA 358
    rs679390311,2
    C--62103098(+) TTGTT-/GTTGTT
            
    ATTGT
    4 -- us2k1 cds11Minor allele frequency- GTTGTT:0.00NA 2
    rs1392121081,2
    --62103137(+) AACCAC/GTGTGG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ASRGL1 (62104774 - 62160887 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ASRGL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv218e199CNV Deletion23128226
    esv1580794CNV Insertion17803354
    nsv468586CNV Loss19166990
    nsv516460CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ASRGL1
    DNA2.0 Custom Variant and Variant Library Synthesis for ASRGL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609212    OMIM disorders: --

    Selected diseases for ASRGL1 (see all 23):    About MalaCards
    telogen effluvium    central nervous system leukemia    sagittal sinus thrombosis    neonatal abstinence syndrome
    lymphosarcoma    aphasia    disseminated intravascular coagulation    sinusitis
    hydrocephalus    paraplegia    intellectual disability    periodontitis
    parkinson's disease    pancreatic cancer    rheumatoid arthritis    arthritis
    pancreatitis    endotheliitis    malaria    cerebritis

    5 diseases from the University of Copenhagen DISEASES database for ASRGL1:
    Leukemia     Lymphoma     Lymphosarcoma     Pancreatitis
    Central nervous system leukemia

    ASRGL1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for ASRGL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 11857030 (1)


    Export disorders for ASRGL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ASRGL1 gene, integrated from 10 sources (see all 51):
    (articles sorted by number of sources associating them with ASRGL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel asparaginase-like protein is a sperm autoantigen in rats. (PubMed id 11984834)1, 2, 9 Bush L.A....Flickinger C.J. (Mol. Reprod. Dev. 2002)
    2. The human asparaginase-like protein 1 hASRGL1 is an Ntn hydrolase with beta-aspartyl peptidase activity. (PubMed id 19839645)1, 2, 9 Cantor J.R.... Georgiou G. (Biochemistry 2009)
    3. Uncoupling intramolecular processing and substrate hydrolysis in the N-terminal nucleophile hydrolase hASRGL1 by circular permutation. (PubMed id 22891768)1, 2 Li W.... Zhang Y. (ACS Chem. Biol. 2012)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease. (PubMed id 23144326)1 Kim D.K....Silverman E.K. (Am. J. Respir. Crit. Care Med. 2012)
    6. Structures of apo and product-bound human L-asparaginase: insights into the mechanism of autoproteolysis and substrate hydrolysis. (PubMed id 22861376)2 Nomme J.... Lavie A. (Biochemistry 2012)
    7. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. Cell growth stimulation by CRASH, an asparaginase-like protein overexpressed in human tumors and metastatic breast cancers. (PubMed id 19414332)1 Weidle U.H....Kaul S. (Anticancer Res. 2009)
    10. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80150 HGNC: 16448 AceView: ASRGL1 Ensembl:ENSG00000162174 euGenes: HUgn80150
    ECgene: ASRGL1 H-InvDB: ASRGL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ASRGL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ASRGL1 gene:
    Search GeneIP for patents involving ASRGL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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