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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ASRGL1 Gene

protein-coding   GIFtS: 59
GCID: GC11P062104

asparaginase like 1
 Explore 16 diseases affiliated with
ASRGL1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ASRGL1    

Aliases
for ASRGL1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Asparaginase Like 11 2     FLJ223161
ALP1 2 3     L-Asparaginase1
ALP11 2     Asparaginase-Like 1 Protein2
Asparaginase-Like Protein 12 3     Beta-Aspartyl-Peptidase1
Isoaspartyl Dipeptidase2 3     Isoaspartyl Peptidase/L-Asparaginase2
CRASH2 3     Beta-Aspartyl-Peptidase1
L-Asparagine Amidohydrolase2 3     EC 3.4.19.53
EC 3.5.1.13 8     

External Ids:    HGNC: 164481   Entrez Gene: 801502   Ensembl: ENSG000001621747   OMIM: 6092125   UniProtKB: Q7L2663   

Export aliases for ASRGL1 gene to outside databases

Previous GC identifers: GC00U991098 GC11P063680 GC11P062355 GC11P061880 GC11P061861 GC11P058433


Summaries
for ASRGL1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: ASGL1_HUMAN, Q7L266
Function: Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of
L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp
beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including
beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys.
Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward
glutamine

Gene Wiki entry for ASRGL1


Genomic Views
for ASRGL1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ASRGL1 gene promoter:
         STAT5B   STAT1   STAT4   STAT1beta   STAT6   STAT5A   STAT1alpha   STAT2   STAT3   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ASRGL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ASRGL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASRGL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.3   Ensembl cytogenetic band:  11q12.3   HGNC cytogenetic band: 11q12.3

ASRGL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASRGL1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P062104:  view genomic region     (about GC identifiers)

Start:
 62,104,774 bp from pter      End:
 62,160,887 bp from pter
Size:
 56,114 bases      Orientation:
 plus strand

Proteins
for ASRGL1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ASGL1_HUMAN, Q7L266 (See protein sequence)
Recommended Name: Isoaspartyl peptidase/L-asparaginase precursor  
Size: 308 amino acids; 32055 Da
Subunit: Heterodimer of an alpha and beta chain produced by autocleavage. This heterodimer may then dimerize in turn,
giving rise to a heterotetramer
Subcellular location: Cytoplasm. Note=Midpiece of sperm tail
Sequence caution: Sequence=BAB15302.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB15302.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence;
6 PDB 3D structures from and Proteopedia for ASRGL1:
3TKJ (3D)        4ET0 (3D)        4GDT (3D)        4GDU (3D)        4GDV (3D)        4GDW (3D)    
Secondary accessions: B2R7Q0 Q567Q4 Q6P1P0 Q8NI34 Q9H6F7
Alternative splicing: 2 isoforms:  Q7L266-1   Q7L266-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ASRGL1: NX_Q7L266

Post-translational modifications:

  • Cleaved into an alpha and beta chain by autocatalysis; this activates the enzyme. The N-terminal residue of the beta
    • subunit is responsible for the nucleophile hydrolase activity1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q7L266

    • 2 DME Specific Peptides for ASRGL1 (Q7L266)
     NKMVGRVGD  STTGHGESILKVNLARL 

    ASRGL1 Protein expression data from MOPED and PaxDb:    About this image 
    ASRGL1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001077395.1  NP_079356.3  

    ENSEMBL proteins: 
     ENSP00000400057   ENSP00000431772   ENSP00000301776   ENSP00000433136   ENSP00000443284  

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    Novus Biologicals ASRGL1 Proteins
    Novus Biologicals ASRGL1 Lysates
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    ProSpec Recombinant Protein for ASRGL1
    Uscn Proteins for ASRGL1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm ISS--
    GO:0015630microtubule cytoskeleton IDA--

    ASRGL1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ASRGL1

    Protein Domains /
    Families
    for ASRGL1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ASRGL1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR000246 Peptidase_T2

    Graphical View of Domain Structure for InterPro Entry Q7L266

    ProtoNet protein and cluster: Q7L266

    1 Blocks protein family: IPB000246 Asparaginase 2 family

    UniProtKB/Swiss-Prot: ASGL1_HUMAN, Q7L266
    Similarity: Belongs to the Ntn-hydrolase family


    Function
    for ASRGL1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ASGL1_HUMAN, Q7L266
    Function: Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of
    L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp
    beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including
    beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys.
    Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward
    glutamine
    Catalytic activity: L-asparagine + H(2)O = L-aspartate + NH(3)
    Catalytic activity: Cleavage of a beta-linked Asp residue from the N-terminus of a polypeptide
    Enzyme regulation: Glycine accelerates autocleavage into an alpha and beta chain
    Biophysicochemical properties: Kinetic parameters: KM=3.4 mM for L-asparagine (L-Asn); KM=0.4 mM for L-aspartic acid
    beta-methyl ester; KM=0.4 mM for L-Asp-L-Phe; KM=1.0 mM for L-Asp-L-Ala;
    Induction: By 5-alpha-di-hydrotestosterone and progesterone

         Enzyme Numbers (IUBMB): EC 3.5.1.11 2 EC 3.4.19.51

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003948NOT N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity IDA19839645
    GO:0004067asparaginase activity IDA19839645
    GO:0008798beta-aspartyl-peptidase activity IDA19839645
    GO:0016787hydrolase activity ----
         
    ASRGL1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ASRGL1 

    miRNA
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    hsa-miR-607 hsa-miR-922 hsa-miR-196a* hsa-miR-3660 hsa-miR-3065-5p hsa-miR-520a-5p hsa-miR-621 hsa-miR-199a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: ASRGL1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Pathways & Interactions
    for ASRGL1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1asparagine degradation I
    		asparagine degradation I1.00


    1 BioSystems Pathway for ASRGL1 
        asparagine degradation I


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ASRGL1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/9 Interacting proteins for ASRGL1 (Q7L2662, 3 ENSP000003017764) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GSK3BP498412, 3MINT-8256877 I2D: score=2 
    MAPK8IP2Q133872, 3MINT-8262396 I2D: score=2 
    TAB1Q157502, 3MINT-8259998 I2D: score=2 
    MAP2K5Q131632, 3, ENSP000001786404MINT-8259855 I2D: score=2 STRING: ENSP00000178640
    RPS3P233963I2D: score=5 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0033345asparagine catabolic process via L-aspartate ISS--

    ASRGL1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ASRGL1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ASRGL1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ASRGL1

    4 HMDB Compounds for ASRGL1    About this table
    CompoundSynonyms CAS #PubMed Ids
    AmmoniaNH3 (see all 31)7664-41-7--
    L-Asparagine(-)-Asparagine (see all 32)70-47-3--
    L-Aspartic acid(+)-Aspartate (see all 41)56-84-8--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 DrugBank Compounds for ASRGL1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Asparagine(-)-Asparagine (see all 15)70-47-3target--17139284 17016423
    L-Aspartic Acid(+)-Aspartic acid (see all 23)56-84-8target--17139284 17016423

    4 Novoseek chemical compound relationships for ASRGL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sq 22536 71.3 2 12606604 (1), 14727527 (1)
    beraprost sodium 70.4 3 14727527 (2), 12606604 (1)
    prostacyclin 26.3 1 12606604 (1)
    adenylate 16.2 1 12606604 (1)

    Search CenterWatch for drugs/clinical trials and news about ASRGL1 / ASGL1 

    Transcripts
    for ASRGL1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ASRGL1 gene (2 alternative transcripts): 
    NM_001083926.1  NM_025080.3  

    Unigene Cluster for ASRGL1:

    Asparaginase like 1
    Hs.535326  [show with all ESTs]
    Unigene Representative Sequence: BX640832
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000415229(uc001nte.4 uc001ntf.4 uc001ntg.4) ENST00000534183
    ENST00000301776 ENST00000525496 ENST00000529226 ENST00000534571 ENST00000526096
    ENST00000528206(uc001nth.1) ENST00000525708 ENST00000533970 ENST00000535727


    miRNA
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    hsa-miR-607 hsa-miR-922 hsa-miR-196a* hsa-miR-3660 hsa-miR-3065-5p hsa-miR-520a-5p hsa-miR-621 hsa-miR-199a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: ASRGL1 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF411076.1 AK090908.1 AK091403.1 AK091894.1 AK225802.1 AK297158.1 AK309845.1 AK313069.1 
    BC006267.2 BC021295.2 BC064963.1 BC093070.1 BX640832.1 

    17 DOTS entries:

    DT.102831842  DT.100783188  DT.100028117  DT.100028119  DT.402167  DT.95247161  DT.92428247  DT.120716913 
    DT.120716927  DT.92428251  DT.95188695  DT.95247674  DT.99959575  DT.120716958  DT.65287104  DT.91861099 
    DT.92428248 

    24/206 AceView cDNA sequences (see all 206):

    CB116680 BM930627 BE896604 AI962178 BU169415 AW440338 AI352590 AI208856 
    AI800322 AA477368 BF821810 AA931265 BU156650 BE783412 AA476944 AI961462 
    BU183811 BM465903 CR617167 BC064963 CR620676 AA236726 AI811358 BQ425447 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ASRGL1 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b
    SP1:                    -                 -                       -                 -                     
    SP2:                    -     -           -                       -                 -                     
    SP3:                    -     -           -     -                 -                 -                     
    SP4:                    -     -           -                                                               
    SP5:                    -                 -     -                 -                                       


    ECgene alternative splicing isoforms for ASRGL1

    Expression
    for ASRGL1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ASRGL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGCCGCTAAT
    ASRGL1 Expression
    About this image

    ASRGL1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartEndocardiumEndocardial Tube CellsEndocardium
    BrainStriatumBrain
    Neural TubeDiencephalic Ventricular ZoneNeural Tube
    Neural TubeMesencephalic Ventricular ZoneNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)

    See ASRGL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ASRGL1

    SOURCE GeneReport for Unigene cluster: Hs.535326

    UniProtKB/Swiss-Prot: ASGL1_HUMAN, Q7L266
    Tissue specificity: Expressed in brain, kidney, testis and tissues of the gastrointestinal tract. Present in sperm (at
    protein level). Over-expressed in uterine, mammary, prostatic and ovarian carcinoma

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    Orthologs
    for ASRGL1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ASRGL1 gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ASRGL11 asparaginase like 1 66.89(n)
    66.44(a)    		   421868  XM_419885.3  XP_419885.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ASRGL16
    		 --
    		 65(a)
    		 1 ↔ 1
    		 1(168188022-168221560)
    African clawed frog
    (Xenopus laevis)    		 Amphibia CF521899.12   -- 73.44(n)    CF521899.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii asrgl11 asparaginase like 1 61.02(n)
    62.71(a)    		   541402  NM_001013529.1  NP_001013547.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG78601 CG7860 53.29(n)
    45.24(a)    		   32488  NM_132811.2  NP_573039.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G161501 Isoaspartyl peptidase/L-asparaginase 2 subunit beta 49.71(n)
    44.98(a)    		   820860  NM_112485.3  NP_566536.1 


    ENSEMBL Gene Tree for ASRGL1 (if available)
    TreeFam Gene Tree for ASRGL1 (if available) 

    Paralogs
    for ASRGL1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ASRGL1 gene
    AGA2  TASP12  
    1 SIMAP similar gene for ASRGL1 using alignment to 4 protein entries:     ASGL1_HUMAN (see all proteins):
    TASP1

    ASRGL1 for paralogs           About GeneDecksing



    Genomic Variants
    for ASRGL1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1084 NCBI SNPs in ASRGL1 are shown (see all 1084)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs734940081,2
    		C--62102834(+) AAAGTC/ACACTT 2 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1420673611,2
    		--62102862(+) GCTAGA/GGAGCT 2 -- us2k10--------
    rs793653621,2
    		--62102873(+) TTCCTA/GAATTA 2 -- us2k10--------
    rs1149683001,2
    		C,F--62102959(+) GGTGCC/TTAGGA 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1394697721,2
    		C--62103070(+) ATGTC-/TTGTTG
                TTGTT     		2 -- us2k10--------
    rs1460941551,2
    		C--62103070(+) ATGTC-/TTGTTGTT 2 -- us2k10--------
    rs679390311,2
    		C--62103075(+) TTGTT-/GTTGTT
                ATTGT     		2 -- us2k11Minor allele frequency- GTTGTT:0.00NA 2
    rs803110681,2
    		--62103093(+) TTGTTA/GTTGTT 2 -- us2k10--------
    rs79287321,2
    		C,F,A--62103096(+) TTGTTA/C/GTTATT 2 -- us2k13WA NA EA 358
    rs1392121081,2
    		--62103137(+) AACCAC/GTGTGG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ASRGL1 (62104774 - 62160887 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ASRGL1
         1 CNV: 48865

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    Disorders / Diseases
    for ASRGL1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ASRGL1 for disorders           About GeneDecksing

    OMIM gene information: 609212    OMIM disorders: --

    16 diseases for ASRGL1:    About MalaCards
    sagittal sinus thrombosis    disseminated intravascular coagulation    neonatal abstinence syndrome    lymphosarcoma
    sinusitis    thrombosis    rheumatoid arthritis    parkinson's disease
    ovarian carcinoma    arthritis    periodontitis    pancreatic cancer
    breast cancer    pancreatitis    carcinoma    prostatitis

    5 diseases from the University of Copenhagen DISEASES database for ASRGL1:
    Hydrocephalus     Paraplegia     Telogen effluvium     Intellectual disability
    Aphasia

    1 Novoseek disease relationship for ASRGL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 11857030 (1)


    Export disorders for ASRGL1 gene to outside databases

    Publications
    for ASRGL1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ASRGL1 gene, integrated from 9 sources (see all 49):
    (articles sorted by number of sources associating them with ASRGL1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel asparaginase-like protein is a sperm autoantigen in rats. (PubMed id 11984834)1, 2, 9 Bush L.A....Flickinger C.J. (2002)
    2. The human asparaginase-like protein 1 hASRGL1 is an N tn hydrolase with beta-aspartyl peptidase activity. (PubMed id 19839645)1, 2, 9 Cantor J.R....Georgiou G. (2009)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Structures of apo and product-bound human L-asparaginase: insights into the mechanism of autoproteolysis and substrate hydrolysis. (PubMed id 22861376)2 Nomme J.... Lavie A. (2012)
    5. Uncoupling intramolecular processing and substrate hydrolysis in the N-terminal nucleophile hydrolase hASRGL1 by circular permutation. (PubMed id 22891768)2 Li W.... Zhang Y. (2012)
    6. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. Cell growth stimulation by CRASH, an asparaginase-lik e protein overexpressed in human tumors and metastatic breast cancers. (PubMed id 19414332)1 Weidle U.H....Kaul S. (2009)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    External Searches for ASRGL1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ASRGL1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80150 HGNC: 16448 AceView: ASRGL1 Ensembl:ENSG00000162174 euGenes: HUgn80150
    ECgene: ASRGL1 H-InvDB: ASRGL1

    Other Databases showing ASRGL1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ASRGL1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ASRGL1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ASRGL1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ASRGL1 gene:
    Search GeneIP for patents involving ASRGL1

    GeneCards and IP:
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