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Aliases for ASRGL1 Gene

Aliases for ASRGL1 Gene

  • Asparaginase Like 1 2 3
  • Asparaginase-Like 1 Protein 2 3
  • Asparaginase-Like Protein 1 3 4
  • L-Asparagine Amidohydrolase 3 4
  • Isoaspartyl Dipeptidase 3 4
  • Beta-Aspartyl-Peptidase 3 4
  • EC 3.5.1.1 4 63
  • CRASH 3 4
  • ALP 3 4
  • Isoaspartyl Peptidase/L-Asparaginase 3
  • L-Asparaginase 3
  • EC 3.4.19.5 4
  • ALP1 3

External Ids for ASRGL1 Gene

Previous GeneCards Identifiers for ASRGL1 Gene

  • GC00U991098
  • GC11P063680
  • GC11P061880
  • GC11P061861
  • GC11P062104
  • GC11P058433

Summaries for ASRGL1 Gene

GeneCards Summary for ASRGL1 Gene

ASRGL1 (Asparaginase Like 1) is a Protein Coding gene. Diseases associated with ASRGL1 include central nervous system leukemia. Among its related pathways are asparagine degradation I. GO annotations related to this gene include N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity and beta-aspartyl-peptidase activity. An important paralog of this gene is TASP1.

UniProtKB/Swiss-Prot for ASRGL1 Gene

  • Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine.

Gene Wiki entry for ASRGL1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASRGL1 Gene

Genomics for ASRGL1 Gene

Regulatory Elements for ASRGL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ASRGL1 Gene

Start:
62,337,302 bp from pter
End:
62,393,415 bp from pter
Size:
56,114 bases
Orientation:
Plus strand

Genomic View for ASRGL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ASRGL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASRGL1 Gene

Proteins for ASRGL1 Gene

  • Protein details for ASRGL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L266-ASGL1_HUMAN
    Recommended name:
    Isoaspartyl peptidase/L-asparaginase
    Protein Accession:
    Q7L266
    Secondary Accessions:
    • B2R7Q0
    • Q567Q4
    • Q6P1P0
    • Q8NI34
    • Q9H6F7

    Protein attributes for ASRGL1 Gene

    Size:
    308 amino acids
    Molecular mass:
    32055 Da
    Quaternary structure:
    • Heterodimer of an alpha and beta chain produced by autocleavage. This heterodimer may then dimerize in turn, giving rise to a heterotetramer.
    SequenceCaution:
    • Sequence=BAB15302.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15302.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ASRGL1 Gene

    Alternative splice isoforms for ASRGL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASRGL1 Gene

Proteomics data for ASRGL1 Gene at MOPED

Selected DME Specific Peptides for ASRGL1 Gene

Post-translational modifications for ASRGL1 Gene

  • Cleaved into an alpha and beta chain by autocatalysis; this activates the enzyme. The N-terminal residue of the beta subunit is responsible for the nucleophile hydrolase activity
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for ASRGL1 Gene

Protein Domains for ASRGL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q7L266

UniProtKB/Swiss-Prot:

ASGL1_HUMAN :
  • Q7L266
Family:
  • Belongs to the Ntn-hydrolase family.
genes like me logo Genes that share domains with ASRGL1: view

No data available for Gene Families for ASRGL1 Gene

Function for ASRGL1 Gene

Molecular function for ASRGL1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=3.4 mM for L-asparagine (L-Asn) {ECO:0000269 PubMed:19839645}; KM=0.4 mM for L-aspartic acid beta-methyl ester {ECO:0000269 PubMed:19839645}; KM=0.4 mM for L-Asp-L-Phe {ECO:0000269 PubMed:19839645}; KM=1.0 mM for L-Asp-L-Ala {ECO:0000269 PubMed:19839645};
UniProtKB/Swiss-Prot CatalyticActivity: L-asparagine + H(2)O = L-aspartate + NH(3)
UniProtKB/Swiss-Prot CatalyticActivity: Cleavage of a beta-linked Asp residue from the N-terminus of a polypeptide
UniProtKB/Swiss-Prot EnzymeRegulation: Glycine accelerates autocleavage into an alpha and beta chain.
UniProtKB/Swiss-Prot Function: Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine.
UniProtKB/Swiss-Prot Induction: By 5-alpha-di-hydrotestosterone and progesterone.

Enzyme Numbers (IUBMB) for ASRGL1 Gene

Gene Ontology (GO) - Molecular Function for ASRGL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003948 NOT N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity IDA 19839645
GO:0004067 asparaginase activity IDA 19839645
GO:0008798 beta-aspartyl-peptidase activity IDA 19839645
GO:0016787 hydrolase activity --
genes like me logo Genes that share ontologies with ASRGL1: view

Animal Model Products

CRISPR Products

miRNA for ASRGL1 Gene

miRTarBase miRNAs that target ASRGL1

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ASRGL1 Gene

Localization for ASRGL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ASRGL1 Gene

Cytoplasm. Note=Midpiece of sperm tail.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ASRGL1 Gene COMPARTMENTS Subcellular localization image for ASRGL1 gene
Compartment Confidence
cytoskeleton 4
nucleus 4
cytosol 2
extracellular 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ASRGL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with ASRGL1: view

Pathways for ASRGL1 Gene

SuperPathways for ASRGL1 Gene

Superpath Contained pathways
1 asparagine degradation I
genes like me logo Genes that share pathways with ASRGL1: view

Pathways by source for ASRGL1 Gene

1 BioSystems pathway for ASRGL1 Gene

Interacting Proteins for ASRGL1 Gene

Gene Ontology (GO) - Biological Process for ASRGL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0008152 metabolic process --
GO:0033345 asparagine catabolic process via L-aspartate ISS --
genes like me logo Genes that share ontologies with ASRGL1: view

Compounds for ASRGL1 Gene

(4) HMDB Compounds for ASRGL1 Gene

Compound Synonyms Cas Number PubMed IDs
Ammonia
  • NH3
7664-41-7
L-Asparagine
  • (-)-Asparagine
70-47-3
L-Aspartic acid
  • (+)-Aspartate
56-84-8
Water
  • Dihydrogen oxide
7732-18-5

(2) Drugbank Compounds for ASRGL1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Asparagine
  • (-)-Asparagine
70-47-3 target
L-Aspartic Acid
  • (+)-Aspartic acid
56-84-8 target

(4) Novoseek inferred chemical compound relationships for ASRGL1 Gene

Compound -log(P) Hits PubMed IDs
sq 22536 71.3 2
beraprost sodium 70.4 3
prostacyclin 26.3 1
adenylate 16.2 1
genes like me logo Genes that share compounds with ASRGL1: view

Transcripts for ASRGL1 Gene

Unigene Clusters for ASRGL1 Gene

Asparaginase like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ASRGL1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ASRGL1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b
SP1: - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - -
SP5: - - - -
SP6: -
SP7: -
SP8:

Relevant External Links for ASRGL1 Gene

GeneLoc Exon Structure for
ASRGL1
ECgene alternative splicing isoforms for
ASRGL1

Expression for ASRGL1 Gene

mRNA expression in normal human tissues for ASRGL1 Gene

mRNA differential expression in normal tissues according to GTEx for ASRGL1 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ASRGL1 Gene

SOURCE GeneReport for Unigene cluster for ASRGL1 Gene Hs.535326

mRNA Expression by UniProt/SwissProt for ASRGL1 Gene

Q7L266-ASGL1_HUMAN
Tissue specificity: Expressed in brain, kidney, testis and tissues of the gastrointestinal tract. Present in sperm (at protein level). Over-expressed in uterine, mammary, prostatic and ovarian carcinoma.
genes like me logo Genes that share expressions with ASRGL1: view

In Situ Assay Products

Orthologs for ASRGL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ASRGL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ASRGL1 35
  • 99.24 (n)
  • 98.38 (a)
ASRGL1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ASRGL1 35
  • 82.3 (n)
  • 82.41 (a)
ASRGL1 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ASRGL1 35
  • 83.23 (n)
  • 83.12 (a)
ASRGL1 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Asrgl1 35
  • 79.56 (n)
  • 78.36 (a)
Asrgl1 16
Asrgl1 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ASRGL1 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ASRGL1 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Asrgl1 35
  • 78.58 (n)
  • 77.7 (a)
chicken
(Gallus gallus)
Aves ASRGL1 35
  • 67.34 (n)
  • 66.44 (a)
ASRGL1 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ASRGL1 36
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii asrgl1 35
  • 61.24 (n)
  • 62.71 (a)
asrgl1 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7860 36
  • 39 (a)
OneToOne
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6054 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G16150 35
  • 49.6 (n)
  • 45.33 (a)
Species with no ortholog for ASRGL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ASRGL1 Gene

ENSEMBL:
Gene Tree for ASRGL1 (if available)
TreeFam:
Gene Tree for ASRGL1 (if available)

Paralogs for ASRGL1 Gene

Paralogs for ASRGL1 Gene

Selected SIMAP similar genes for ASRGL1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ASRGL1: view

Variants for ASRGL1 Gene

Sequence variations from dbSNP and Humsavar for ASRGL1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs6863 -- 62,393,253(-) GCCCA(A/C)CGAGG utr-variant-3-prime
rs15810 -- 62,392,494(-) CCTCC(A/T)GGGCT utr-variant-3-prime
rs951677 -- 62,339,777(+) ACTTG(C/G)TGGAA intron-variant
rs1043785 -- 62,393,251(+) TTCCT(C/T)GGTGG utr-variant-3-prime
rs1043789 -- 62,393,257(+) GGTGG(A/G)CAGTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ASRGL1 Gene

Variant ID Type Subtype PubMed ID
nsv516460 CNV Gain 19592680
dgv218e199 CNV Deletion 23128226
nsv468586 CNV Loss 19166990
esv1580794 CNV Insertion 17803354

Relevant External Links for ASRGL1 Gene

HapMap Linkage Disequilibrium report
ASRGL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASRGL1 Gene

Disorders for ASRGL1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ASRGL1 Gene including...

Search for ASRGL1 Gene in MalaCards »

(5) University of Copenhagen DISEASES for ASRGL1 Gene

(1) Novoseek inferred disease relationships for ASRGL1 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 1
genes like me logo Genes that share disorders with ASRGL1: view

No data available for UniProtKB/Swiss-Prot for ASRGL1 Gene

Publications for ASRGL1 Gene

  1. A novel asparaginase-like protein is a sperm autoantigen in rats. (PMID: 11984834) Bush L.A. … Flickinger C.J. (Mol. Reprod. Dev. 2002) 3 4 23
  2. The human asparaginase-like protein 1 hASRGL1 is an Ntn hydrolase with beta-aspartyl peptidase activity. (PMID: 19839645) Cantor J.R. … Georgiou G. (Biochemistry 2009) 3 4 23
  3. Uncoupling intramolecular processing and substrate hydrolysis in the N-terminal nucleophile hydrolase hASRGL1 by circular permutation. (PMID: 22891768) Li W. … Zhang Y. (ACS Chem. Biol. 2012) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3

Products for ASRGL1 Gene

Sources for ASRGL1 Gene

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