Aliases for ASRGL1 Gene
Aliases for ASRGL1 Gene
External Ids for ASRGL1 Gene
- HGNC: 16448
- Entrez Gene: 80150
- Ensembl: ENSG00000162174
- OMIM: 609212
- UniProtKB: Q7L266
Previous GeneCards Identifiers for ASRGL1 Gene
- GC00U991098
- GC11P063680
- GC11P061880
- GC11P061861
- GC11P062104
- GC11P058433
Summaries for ASRGL1 Gene
GeneCards Summary for ASRGL1 Gene
ASRGL1 (Asparaginase Like 1) is a Protein Coding gene. Diseases associated with ASRGL1 include Masa Syndrome. Among its related pathways are asparagine degradation and Viral mRNA Translation. GO annotations related to this gene include hydrolase activity and asparaginase activity. An important paralog of this gene is TASP1.
UniProtKB/Swiss-Prot for ASRGL1 Gene
-
Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASRGL1 Gene
Genomics for ASRGL1 Gene
Regulatory Elements for ASRGL1 Gene
Enhancers for ASRGL1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ASRGL1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the ASRGL1 gene promoter:
Regulatory Element Products
Genomic Location for ASRGL1 Gene
- Chromosome:
- 11
- Start:
- 62,337,302 bp from pter
- End:
- 62,401,378 bp from pter
- Size:
- 64,077 bases
- Orientation:
- Plus strand
Genomic View for ASRGL1 Gene
Genes around ASRGL1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q12.3 by Ensembl
- 11q12.3 by Entrez Gene
- 11q12.3 by HGNC
ASRGL1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ASRGL1 Gene
Proteins for ASRGL1 Gene
-
Protein details for ASRGL1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q7L266-ASGL1_HUMAN
- Recommended name:
- Isoaspartyl peptidase/L-asparaginase
- Protein Accession:
- Q7L266
- B2R7Q0
- Q567Q4
- Q6P1P0
- Q8NI34
- Q9H6F7
Protein attributes for ASRGL1 Gene
- Size:
- 308 amino acids
- Molecular mass:
- 32055 Da
- Quaternary structure:
-
- Heterodimer of an alpha and beta chain produced by autocleavage. This heterodimer may then dimerize in turn, giving rise to a heterotetramer.
- SequenceCaution:
-
- Sequence=BAB15302.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15302.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for ASRGL1 Gene
Protein Expression for ASRGL1 Gene
Selected DME Specific Peptides for ASRGL1 Gene
- Q7L266:
-
- STTGHGESILKVNLARL
- NKMVGRVGD
Post-translational modifications for ASRGL1 Gene
- Cleaved into an alpha and beta chain by autocatalysis; this activates the enzyme. The N-terminal residue of the beta subunit is responsible for the nucleophile hydrolase activity.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for ASRGL1 Gene
Antibody Products
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- antibodies-online Antibodies for ASRGL1: See all 158
- GeneTex ASRGL1 antibody for ASRGL1
-
Santa Cruz Biotechnology (SCBT) Antibodies for ASRGL1
Protein Products
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OriGene Purified Proteins for ASRGL1
- Search Origene for MassSpec and Protein Over-expression Lysates for ASRGL1
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- ProSpec Recombinant Proteins for ASRGL1
- antibodies-online Proteins for ASRGL1: See all 11
- Search antibodies-online for peptides
- Search GeneTex for Proteins for ASRGL1
Assay Products
- antibodies-online Kits for ASRGL1: See all 35
Domains & Families for ASRGL1 Gene
Protein Domains for ASRGL1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ASRGL1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q7L266- Family:
-
- Belongs to the Ntn-hydrolase family.
No data available for Gene Families for ASRGL1 Gene
Function for ASRGL1 Gene
Molecular function for ASRGL1 Gene
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=3.4 mM for L-asparagine (L-Asn) {ECO:0000269 PubMed:19839645}; KM=0.4 mM for L-aspartic acid beta-methyl ester {ECO:0000269 PubMed:19839645}; KM=0.4 mM for L-Asp-L-Phe {ECO:0000269 PubMed:19839645}; KM=1.0 mM for L-Asp-L-Ala {ECO:0000269 PubMed:19839645};
- UniProtKB/Swiss-Prot CatalyticActivity:
- L-asparagine + H(2)O = L-aspartate + NH(3).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Cleavage of a beta-linked Asp residue from the N-terminus of a polypeptide.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Glycine accelerates autocleavage into an alpha and beta chain.
- UniProtKB/Swiss-Prot Function:
- Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine.
- UniProtKB/Swiss-Prot Induction:
- By 5-alpha-di-hydrotestosterone and progesterone.
Enzyme Numbers (IUBMB) for ASRGL1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003948 | NOT N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity | IDA | 19839645 |
| GO:0004067 | asparaginase activity | IDA | 19839645 |
| GO:0008233 | peptidase activity | IEA | -- |
| GO:0008798 | beta-aspartyl-peptidase activity | TAS | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for ASRGL1 Gene
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for ASRGL1 gene
-
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- Search ViGene Biosciences for ASRGL1
CRISPR Products
-
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-
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miRNA for ASRGL1 Gene
- miRTarBase miRNAs that target ASRGL1
miRNA Products
- Search ViGene Biosciences for ASRGL1
Inhibitory RNA Products
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-
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ASRGL1
-
ViGene Biosciences adenoviral particle packaged cDNA for ASRGL1 gene
-
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-
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Flow Cytometry Products
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ASRGL1 Gene
Localization for ASRGL1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ASRGL1 Gene
- Cytoplasm. Note=Midpiece of sperm tail.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| cytoskeleton | 2 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 21630459 |
| GO:0005737 | cytoplasm | ISS | -- |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for ASRGL1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism | ||
| 2 | Metabolism |
.37
|
|
| 3 | Viral mRNA Translation | ||
| 4 | asparagine degradation | ||
Pathways by source for ASRGL1 Gene
1 BioSystems pathway for ASRGL1 Gene
Interacting Proteins for ASRGL1 Gene
Selected Interacting proteins:
Q7L266-ASGL1_HUMAN
ENSP00000301776
for ASRGL1 Gene via
MINT
STRING
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006508 | proteolysis | IEA | -- |
| GO:0006559 | L-phenylalanine catabolic process | TAS | -- |
| GO:0033345 | asparagine catabolic process via L-aspartate | ISS | -- |
No data available for SIGNOR curated interactions for ASRGL1 Gene
Drugs & Compounds for ASRGL1 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Ammonia |
|
7664-41-7 |
|
Transcripts for ASRGL1 Gene
mRNA/cDNA for ASRGL1 Gene
- (7) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (206) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for ASRGL1
-
Santa Cruz Biotechnology (SCBT) CRISPR for ASRGL1
- GenScript: Design CRISPR guide RNA sequences for ASRGL1
miRNA Products
- Search ViGene Biosciences for ASRGL1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ASRGL1
- Browse OriGene Inhibitory RNA Products For ASRGL1
-
ViGene Biosciences ready-to-package AAV shRNAs for ASRGL1 gene
Clone Products
- Sino Biological Human cDNA Clone for ASRGL1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ASRGL1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ASRGL1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||||||
| SP8: |
Expression for ASRGL1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
- Seminiferous Tubules
- Testis Interstitium
-
Glial Cells
- Protoplasmic Astrocyte Cells Neocortex
-
Spinal Cord (Nervous System)
mRNA differential expression in normal tissues according to GTEx for ASRGL1 Gene
This gene is overexpressed in Brain - Putamen (basal ganglia) (x4.4).
This gene is overexpressed in Liver (25.2) and Ovary (18.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ASRGL1 Gene
NURSA nuclear receptor signaling pathways regulating expression of ASRGL1 Gene:
ASRGL1SOURCE GeneReport for Unigene cluster for ASRGL1 Gene:
Hs.535326mRNA Expression by UniProt/SwissProt for ASRGL1 Gene:
Q7L266-ASGL1_HUMAN
Tissue specificity:
Expressed in brain, kidney, testis and tissues of the gastrointestinal tract. Present in sperm (at protein level). Over-expressed in uterine, mammary, prostatic and ovarian carcinoma.
Evidence on tissue expression from TISSUES for ASRGL1 Gene
- Nervous system(4.9)
- Eye(4.3)
- Lung(4.3)
- Skin(4.1)
Primer Products
-
OriGene qPCR primer pairs for ASRGL1
-
OriGene qPCR primer pairs and template standards for ASRGL1
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ASRGL1 Gene
Orthologs for ASRGL1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ASRGL1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | ASRGL1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | ASRGL1 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Asrgl1 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Asrgl1 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ASRGL1 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | ASRGL1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ASRGL1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ASRGL1 35 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | asrgl1 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG7860 35 |
|
OneToOne | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT3G16150 34 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.6054 34 |
|
- Species where no ortholog for ASRGL1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ASRGL1 Gene
(1) SIMAP similar genes for ASRGL1 Gene using alignment to 4 proteins:
Variants for ASRGL1 Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000017071 | -- | 62,378,487(+) | TTATG(C/G)CTGGT | intron-variant | |
| rs1000031432 | -- | 62,364,663(+) | CTTGG(G/T)AGGAA | intron-variant | |
| rs1000090850 | -- | 62,371,914(+) | GCGCC(A/G)CTGCA | intron-variant | |
| rs1000122886 | -- | 62,355,800(+) | TACTT(C/G)AGATT | intron-variant | |
| rs1000156768 | -- | 62,373,345(+) | ACTAC(C/T)TTTTT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv202e214 | CNV | loss | 21293372 |
| dgv218e199 | CNV | deletion | 23128226 |
| esv1580794 | CNV | insertion | 17803354 |
| esv3408585 | CNV | insertion | 20981092 |
| esv3626599 | CNV | gain | 21293372 |
| esv3626600 | CNV | gain | 21293372 |
| esv3626603 | CNV | gain | 21293372 |
| esv3626604 | CNV | loss | 21293372 |
| nsv1039105 | CNV | gain | 25217958 |
| nsv1053587 | CNV | gain | 25217958 |
| nsv468586 | CNV | loss | 19166990 |
| nsv516460 | CNV | gain | 19592680 |
| nsv555172 | CNV | loss | 21841781 |
| nsv555173 | CNV | loss | 21841781 |
| nsv983031 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
47.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.20;
24.18% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ASRGL1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASRGL1 Gene
Disorders for ASRGL1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| masa syndrome |
|
|
Search ASRGL1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for ASRGL1
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- ASRGL1
No data available for UniProtKB/Swiss-Prot and Genatlas for ASRGL1 Gene
Publications for ASRGL1 Gene
- The human asparaginase-like protein 1 hASRGL1 is an Ntn hydrolase with beta-aspartyl peptidase activity. (PMID: 19839645) Cantor J.R. … Georgiou G. (Biochemistry 2009) 3 4 22 64
- A novel asparaginase-like protein is a sperm autoantigen in rats. (PMID: 11984834) Bush L.A. … Flickinger C.J. (Mol. Reprod. Dev. 2002) 3 4 22 64
- Uncoupling intramolecular processing and substrate hydrolysis in the N-terminal nucleophile hydrolase hASRGL1 by circular permutation. (PMID: 22891768) Li W. … Zhang Y. (ACS Chem. Biol. 2012) 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- Intramolecular Cleavage of the hASRGL1 Homodimer Occurs in Two Stages. (PMID: 26780688) Li W. … Stone E. (Biochemistry 2016) 3 64
Products for ASRGL1 Gene
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- antibodies-online Antibodies for ASRGL1: See all 158
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- GeneTex ASRGL1 antibody for ASRGL1
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- ViGene Biosciences adenoviral particle packaged cDNA for ASRGL1 gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for ASRGL1
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- Santa Cruz Biotechnology (SCBT) CRISPR for ASRGL1
- Horizon Cell Lines for ASRGL1
- Cyagen custom Knockout/knockin (KOKI) mouse models for ASRGL1
- VectorBuilder custom plasmid, inducible vectors for ASRGL1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ASRGL1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ASRGL1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
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