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Aliases for ASPRV1 Gene

Aliases for ASPRV1 Gene

  • Aspartic Peptidase, Retroviral-Like 1 2 3
  • Taps 3 4 6
  • SASP 3 4 6
  • Skin-Specific Retroviral-Like Aspartic Protease 3 4
  • TPA-Inducible Aspartic Proteinase-Like Protein 3 4
  • Skin Aspartic Protease 3 4
  • SASPase 3 4
  • MUNO 3 6
  • Retroviral-Like Aspartic Protease 1 3
  • Skin ASpartic Protease 2
  • EC 3.4.23.- 4

External Ids for ASPRV1 Gene

Previous GeneCards Identifiers for ASPRV1 Gene

  • GC02M070041
  • GC02M070187
  • GC02M069923

Summaries for ASPRV1 Gene

GeneCards Summary for ASPRV1 Gene

ASPRV1 (Aspartic Peptidase, Retroviral-Like 1) is a Protein Coding gene. GO annotations related to this gene include aspartic-type endopeptidase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASPRV1 Gene

Genomics for ASPRV1 Gene

Regulatory Elements for ASPRV1 Gene

Genomic Location for ASPRV1 Gene

Start:
69,960,089 bp from pter
End:
69,962,265 bp from pter
Size:
2,177 bases
Orientation:
Minus strand

Genomic View for ASPRV1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ASPRV1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASPRV1 Gene

Proteins for ASPRV1 Gene

  • Protein details for ASPRV1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53RT3-APRV1_HUMAN
    Recommended name:
    Retroviral-like aspartic protease 1
    Protein Accession:
    Q53RT3
    Secondary Accessions:
    • Q8N5P2
    • Q96LT3
    • Q96N43

    Protein attributes for ASPRV1 Gene

    Size:
    343 amino acids
    Molecular mass:
    36991 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=BAB71587.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ASPRV1 Gene

Proteomics data for ASPRV1 Gene at MOPED

Post-translational modifications for ASPRV1 Gene

  • Undergoes autocleavage which is necessary for activation of the protein.
  • Glycosylation at Asn276
  • Modification sites at PhosphoSitePlus

Other Protein References for ASPRV1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ASPRV1 Gene

Domains for ASPRV1 Gene

Protein Domains for ASPRV1 Gene

Suggested Antigen Peptide Sequences for ASPRV1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q53RT3

UniProtKB/Swiss-Prot:

APRV1_HUMAN :
  • Q53RT3
Domain:
  • Contains 1 peptidase A2 domain.
genes like me logo Genes that share domains with ASPRV1: view

No data available for Gene Families for ASPRV1 Gene

Function for ASPRV1 Gene

Enzyme Numbers (IUBMB) for ASPRV1 Gene

Gene Ontology (GO) - Molecular Function for ASPRV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004190 aspartic-type endopeptidase activity IDA 16098038
genes like me logo Genes that share ontologies with ASPRV1: view

Phenotypes for ASPRV1 Gene

MGI mutant phenotypes for ASPRV1:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with ASPRV1: view

Animal Models for ASPRV1 Gene

MGI Knock Outs for ASPRV1:

miRNA for ASPRV1 Gene

miRTarBase miRNAs that target ASPRV1

No data available for Molecular function , Transcription Factor Targeting and HOMER Transcription for ASPRV1 Gene

Localization for ASPRV1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ASPRV1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ASPRV1 Gene COMPARTMENTS Subcellular localization image for ASPRV1 gene
Compartment Confidence
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ASPRV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane NAS 16098038
genes like me logo Genes that share ontologies with ASPRV1: view

Pathways for ASPRV1 Gene

SuperPathways for ASPRV1 Gene

No Data Available

Interacting Proteins for ASPRV1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000315383%0d%0a9606.ENSP00000294008%0d%0a9606.ENSP00000356425%0d%0a
Selected Interacting proteins: ENSP00000315383 Q53RT3-APRV1_HUMAN for ASPRV1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for ASPRV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis --
GO:0016485 protein processing IDA 16098038
GO:0043588 skin development ISS --
genes like me logo Genes that share ontologies with ASPRV1: view

No data available for Pathways by source for ASPRV1 Gene

Transcripts for ASPRV1 Gene

mRNA/cDNA for ASPRV1 Gene

(39) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ASPRV1 Gene

Aspartic peptidase, retroviral-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ASPRV1 Gene

No ASD Table

Relevant External Links for ASPRV1 Gene

GeneLoc Exon Structure for
ASPRV1
ECgene alternative splicing isoforms for
ASPRV1

Expression for ASPRV1 Gene

mRNA expression in normal human tissues for ASPRV1 Gene

mRNA differential expression in normal tissues according to GTEx for ASPRV1 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (25.5) and Skin - Not Sun Exposed (Suprapubic) (16.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ASPRV1 Gene

SOURCE GeneReport for Unigene cluster for ASPRV1 Gene Hs.516253

mRNA Expression by UniProt/SwissProt for ASPRV1 Gene

Q53RT3-APRV1_HUMAN
Tissue specificity: Expressed primarily in the granular layer of the epidermis and inner root sheath of hair follicles. In psoriatic skin, expressed throughout the stratum corneum. In ulcerated skin, expressed in the stratum granulosum of intact epidermis but almost absent from ulcerated regions. Expressed in differentiated areas of squamous cell carcinomas but not in undifferentiated tumors.
genes like me logo Genes that share expressions with ASPRV1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ASPRV1 Gene

Orthologs for ASPRV1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ASPRV1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ASPRV1 35
  • 99.32 (n)
  • 98.25 (a)
ASPRV1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ASPRV1 35
  • 85.77 (n)
  • 83.23 (a)
dog
(Canis familiaris)
Mammalia ASPRV1 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Asprv1 35
  • 75.05 (n)
  • 74.24 (a)
Asprv1 16
Asprv1 36
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ASPRV1 36
  • 64 (a)
OneToOne
Species with no ortholog for ASPRV1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ASPRV1 Gene

ENSEMBL:
Gene Tree for ASPRV1 (if available)
TreeFam:
Gene Tree for ASPRV1 (if available)

Paralogs for ASPRV1 Gene

No data available for Paralogs for ASPRV1 Gene

Variants for ASPRV1 Gene

Sequence variations from dbSNP and Humsavar for ASPRV1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs2276686 -- 69,959,593(+) TCCCA(A/C)CGCCG downstream-variant-500B
rs3087933 -- 69,960,406(+) ATCAA(C/T)AGCAG utr-variant-3-prime
rs3796097 - 69,961,544(+) CAGAG(C/T)GGGGA reference, missense
rs3821276 -- 69,960,041(+) TGATG(C/T)TGACT downstream-variant-500B
rs12464297 -- 69,960,595(+) ATGCA(A/C)CCCCC utr-variant-3-prime

Relevant External Links for ASPRV1 Gene

HapMap Linkage Disequilibrium report
ASPRV1
Human Gene Mutation Database (HGMD)
ASPRV1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ASPRV1 Gene

Disorders for ASPRV1 Gene

No disorders were found for ASPRV1 Gene.

No data available for UniProtKB/Swiss-Prot for ASPRV1 Gene

Publications for ASPRV1 Gene

  1. Identification and characterization of a novel retroviral-like aspartic protease specifically expressed in human epidermis. (PMID: 16098038) Bernard D. … Schmidt R. (J. Invest. Dermatol. 2005) 2 3 4 23
  2. A novel aspartic proteinase-like gene expressed in stratified epithelia and squamous cell carcinoma of the skin. (PMID: 16565508) Rhiemeier V. … Angel P. (Am. J. Pathol. 2006) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4

Products for ASPRV1 Gene

Sources for ASPRV1 Gene

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