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Aliases for ASPHD2 Gene

Aliases for ASPHD2 Gene

  • Aspartate Beta-Hydroxylase Domain Containing 2 2 3
  • EC 1.14.11.- 4
  • EC 1.14.11 64

External Ids for ASPHD2 Gene

Summaries for ASPHD2 Gene

GeneCards Summary for ASPHD2 Gene

ASPHD2 (Aspartate Beta-Hydroxylase Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include dioxygenase activity. An important paralog of this gene is ASPH.

UniProtKB/Swiss-Prot for ASPHD2 Gene

  • May function as 2-oxoglutarate-dependent dioxygenase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASPHD2 Gene

Genomics for ASPHD2 Gene

Genomic Location for ASPHD2 Gene

Start:
26,429,273 bp from pter
End:
26,445,015 bp from pter
Size:
15,743 bases
Orientation:
Plus strand

Genomic View for ASPHD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ASPHD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASPHD2 Gene

Regulatory Elements for ASPHD2 Gene

Proteins for ASPHD2 Gene

  • Protein details for ASPHD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ICH7-ASPH2_HUMAN
    Recommended name:
    Aspartate beta-hydroxylase domain-containing protein 2
    Protein Accession:
    Q6ICH7
    Secondary Accessions:
    • B2RCH3
    • Q7L0W3
    • Q9NSN3

    Protein attributes for ASPHD2 Gene

    Size:
    369 amino acids
    Molecular mass:
    41699 Da
    Cofactor:
    Name=Fe cation; Xref=ChEBI:CHEBI:24875;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH36753.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG37570.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ASPHD2 Gene

Proteomics data for ASPHD2 Gene at MOPED

Selected DME Specific Peptides for ASPHD2 Gene

Post-translational modifications for ASPHD2 Gene

Other Protein References for ASPHD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for ASPHD2 Gene

Protein Domains for ASPHD2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

ASPH2_HUMAN
Family:
  • Belongs to the aspartyl/asparaginyl beta-hydroxylase family.:
    • Q6ICH7
genes like me logo Genes that share domains with ASPHD2: view

No data available for Gene Families for ASPHD2 Gene

Function for ASPHD2 Gene

Molecular function for ASPHD2 Gene

UniProtKB/Swiss-Prot Function: May function as 2-oxoglutarate-dependent dioxygenase.

Enzyme Numbers (IUBMB) for ASPHD2 Gene

Gene Ontology (GO) - Molecular Function for ASPHD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
GO:0051213 dioxygenase activity IEA --
genes like me logo Genes that share ontologies with ASPHD2: view
genes like me logo Genes that share phenotypes with ASPHD2: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ASPHD2 Gene

Localization for ASPHD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ASPHD2 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ASPHD2 Gene COMPARTMENTS Subcellular localization image for ASPHD2 gene
Compartment Confidence
cytosol 2
golgi apparatus 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ASPHD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ASPHD2: view

Pathways for ASPHD2 Gene

SuperPathways for ASPHD2 Gene

No Data Available

Interacting Proteins for ASPHD2 Gene

Gene Ontology (GO) - Biological Process for ASPHD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018193 peptidyl-amino acid modification IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with ASPHD2: view

No data available for Pathways by source for ASPHD2 Gene

Transcripts for ASPHD2 Gene

mRNA/cDNA for ASPHD2 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(67) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ASPHD2 Gene

Aspartate beta-hydroxylase domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ASPHD2 Gene

No ASD Table

Relevant External Links for ASPHD2 Gene

GeneLoc Exon Structure for
ASPHD2
ECgene alternative splicing isoforms for
ASPHD2

Expression for ASPHD2 Gene

mRNA expression in normal human tissues for ASPHD2 Gene

mRNA differential expression in normal tissues according to GTEx for ASPHD2 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (5.3) and Brain - Cerebellar Hemisphere (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ASPHD2 Gene

SOURCE GeneReport for Unigene cluster for ASPHD2 Gene Hs.567547

genes like me logo Genes that share expressions with ASPHD2: view

Orthologs for ASPHD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ASPHD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ASPHD2 36
  • 99.64 (n)
  • 100 (a)
ASPHD2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ASPHD2 36
  • 89.31 (n)
  • 91.84 (a)
ASPHD2 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ASPHD2 36
  • 92.5 (n)
  • 94.85 (a)
ASPHD2 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Asphd2 36
  • 88.44 (n)
  • 94.17 (a)
Asphd2 16
Asphd2 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ASPHD2 37
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Asphd2 36
  • 87.76 (n)
  • 93.59 (a)
chicken
(Gallus gallus)
Aves ASPHD2 36
  • 84.06 (n)
  • 88.05 (a)
ASPHD2 37
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6340 36
tropical clawed frog
(Silurana tropicalis)
Amphibia asphd2 36
  • 72.36 (n)
  • 78.32 (a)
zebrafish
(Danio rerio)
Actinopterygii asphd2 36
  • 67.57 (n)
  • 70.57 (a)
asphd2 37
  • 62 (a)
OneToOne
Dr.17168 36
fruit fly
(Drosophila melanogaster)
Insecta Asph 37
  • 10 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K09A9.6 37
  • 7 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 34 (a)
OneToMany
Species with no ortholog for ASPHD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ASPHD2 Gene

ENSEMBL:
Gene Tree for ASPHD2 (if available)
TreeFam:
Gene Tree for ASPHD2 (if available)

Paralogs for ASPHD2 Gene

Paralogs for ASPHD2 Gene

Selected SIMAP similar genes for ASPHD2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ASPHD2: view

Variants for ASPHD2 Gene

Sequence variations from dbSNP and Humsavar for ASPHD2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs880421 -- 26,431,369(+) TAGCC(G/T)TTTCC intron-variant
rs880422 -- 26,431,575(+) GAAAC(A/T)GGGAA intron-variant
rs1000815 -- 26,435,111(-) aaggc(C/T)gtcta intron-variant
rs2001153 -- 26,436,874(+) AAACA(A/C/T)GCCCA intron-variant
rs2003137 -- 26,432,408(-) ACTCA(A/G)GGAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ASPHD2 Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
esv999415 CNV Loss 20482838

Relevant External Links for ASPHD2 Gene

HapMap Linkage Disequilibrium report
ASPHD2

Disorders for ASPHD2 Gene

Relevant External Links for ASPHD2

Genetic Association Database (GAD)
ASPHD2
Human Genome Epidemiology (HuGE) Navigator
ASPHD2
genes like me logo Genes that share disorders with ASPHD2: view

No data available for UniProtKB/Swiss-Prot for ASPHD2 Gene

Publications for ASPHD2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for ASPHD2 Gene

Sources for ASPHD2 Gene

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