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Aliases for ASPG Gene

Aliases for ASPG Gene

  • Asparaginase 2 3 5
  • C14orf76 3 4
  • Asparaginase Homolog (S. Cerevisiae) 2
  • Chromosome 14 Open Reading Frame 76 2
  • 60-KDa-Lysophospholipase 2
  • 60 KDa Lysophospholipase 3
  • Wild-Type L-Asparaginase 3
  • Asparaginase Homolog 3
  • EC 4
  • GPA/WT 3

External Ids for ASPG Gene

Previous HGNC Symbols for ASPG Gene

  • C14orf76

Previous GeneCards Identifiers for ASPG Gene

  • GC14P103622
  • GC14P104552
  • GC14P084732

Summaries for ASPG Gene

GeneCards Summary for ASPG Gene

ASPG (Asparaginase) is a Protein Coding gene. Among its related pathways are Metabolism and asparagine degradation. GO annotations related to this gene include lysophospholipase activity and asparaginase activity.

UniProtKB/Swiss-Prot for ASPG Gene

  • Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities.

Additional gene information for ASPG Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASPG Gene

Genomics for ASPG Gene

Regulatory Elements for ASPG Gene

Enhancers for ASPG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H104087 1 ENCODE dbSUPER 30.9 +2.8 2753 0.9 FOXA2 PKNOX1 TAF1 MAX RAD21 RARA YY1 HNF4G NR2F6 NFIA ASPG C14orf2 GC14P104113
GH14H104084 1 Ensembl ENCODE dbSUPER 28.2 +0.6 633 2.8 MAX REST KLF8 EZH2 YY1 ASPG C14orf2 GC14P104113
GH14H104093 0.7 dbSUPER 22.8 +7.9 7873 0.6 MAZ SP3 KLF1 ZIC2 ZFHX2 GLIS2 GLIS1 ZNF341 KLF9 ZNF600 ASPG C14orf2 GC14P104113
GH14H104085 0.4 dbSUPER 31.6 -1.2 -1242 0.5 YY1 ASPG C14orf2 LOC105370691
GH14H104100 0.9 ENCODE dbSUPER 9.8 +15.4 15414 1.3 SMARCE1 MAZ ZNF687 MNT KLF4 DPF2 ZNF217 ZFHX2 CTBP1 MTA1 ASPG GC14P104113
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ASPG on UCSC Golden Path with GeneCards custom track

Genomic Locations for ASPG Gene

Genomic Locations for ASPG Gene
29,912 bases
Plus strand

Genomic View for ASPG Gene

Genes around ASPG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASPG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASPG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASPG Gene

Proteins for ASPG Gene

  • Protein details for ASPG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60 kDa lysophospholipase
    Protein Accession:
    Secondary Accessions:
    • B9EGQ2
    • Q8IV80

    Protein attributes for ASPG Gene

    573 amino acids
    Molecular mass:
    60883 Da
    Quaternary structure:
    • Monomer.
    • Sequence=CAD62331.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Alternative splice isoforms for ASPG Gene


neXtProt entry for ASPG Gene

Post-translational modifications for ASPG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ASPG Gene

Domains & Families for ASPG Gene

Gene Families for ASPG Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ASPG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • In the N-terminal section; belongs to the asparaginase 1 family.
  • In the N-terminal section; belongs to the asparaginase 1 family.
genes like me logo Genes that share domains with ASPG: view

Function for ASPG Gene

Molecular function for ASPG Gene

UniProtKB/Swiss-Prot CatalyticActivity:
2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate.
UniProtKB/Swiss-Prot CatalyticActivity:
L-asparagine + H(2)O = L-aspartate + NH(3).
UniProtKB/Swiss-Prot CatalyticActivity:
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H(2)O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.
UniProtKB/Swiss-Prot Function:
Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities.

Enzyme Numbers (IUBMB) for ASPG Gene

Phenotypes From GWAS Catalog for ASPG Gene

Gene Ontology (GO) - Molecular Function for ASPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity IEA --
GO:0004067 asparaginase activity IEA,TAS --
GO:0004622 lysophospholipase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with ASPG: view

Phenotypes for ASPG Gene

genes like me logo Genes that share phenotypes with ASPG: view

Animal Model Products

CRISPR Products

miRNA for ASPG Gene

miRTarBase miRNAs that target ASPG

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ASPG Gene

Localization for ASPG Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ASPG gene
Compartment Confidence
cytosol 5
mitochondrion 3
lysosome 1

Gene Ontology (GO) - Cellular Components for ASPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ASPG: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for ASPG Gene

Pathways & Interactions for ASPG Gene

genes like me logo Genes that share pathways with ASPG: view

Pathways by source for ASPG Gene

Gene Ontology (GO) - Biological Process for ASPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006520 cellular amino acid metabolic process IEA --
GO:0006530 asparagine catabolic process IBA --
GO:0006629 lipid metabolic process IEA --
GO:0008652 cellular amino acid biosynthetic process TAS --
GO:0016042 lipid catabolic process IEA --
genes like me logo Genes that share ontologies with ASPG: view

No data available for SIGNOR curated interactions for ASPG Gene

Drugs & Compounds for ASPG Gene

(11) Drugs for ASPG Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ammonia Approved Pharma 0
Water Approved Pharma 0
acetic acid Approved Nutra Full agonist, Agonist 115
L-Asparagine Approved Nutra 0
L-Aspartic acid Approved Nutra 0

(39) Additional Compounds for ASPG Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
Heptadecanoic acid
  • Heptadecanoate
  • Heptadecanoic acid
  • Margarate
  • Margaric acid
  • Margarinate
Heptadecanoyl CoA
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid coa
  • Heptadecanoyl coenzyme A
  • Heptadecanoyl-coA
  • 1-Hydroxy-2-Octadecanoyl-sn-glycero-3-phosphocholine
  • 1-Hydroxy-2-stearoyl-sn-glycero-3-phosphocholine
  • Lysophosphatidylcholine
  • Stearoyl lysophosphatidylcholine
  • 1-Capryl-2-lysophosphatidylcholine
  • 1-Capryl-L-alpha-phosphorylcholine
  • 1-Decanoyl-sn-glycero-3-phosphocholine
  • 1-Decanoyl-sn-glycerol-3-phosphorylcholine
  • 1-Decanoyllysolecithin
genes like me logo Genes that share compounds with ASPG: view

Transcripts for ASPG Gene

Unigene Clusters for ASPG Gene

Asparaginase homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ASPG Gene

No ASD Table

Relevant External Links for ASPG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ASPG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ASPG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ASPG Gene

This gene is overexpressed in Liver (x20.2) and Heart - Atrial Appendage (x14.1).

Protein differential expression in normal tissues from HIPED for ASPG Gene

This gene is overexpressed in Liver (28.3), Kidney (16.1), Gallbladder (11.1), and Esophagus (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ASPG Gene

Protein tissue co-expression partners for ASPG Gene

NURSA nuclear receptor signaling pathways regulating expression of ASPG Gene:


SOURCE GeneReport for Unigene cluster for ASPG Gene:


Evidence on tissue expression from TISSUES for ASPG Gene

  • Kidney(4.2)
  • Liver(2.2)
genes like me logo Genes that share expression patterns with ASPG: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ASPG Gene

Orthologs for ASPG Gene

This gene was present in the common ancestor of animals.

Orthologs for ASPG Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ASPG 33 34
  • 98.37 (n)
(Bos Taurus)
Mammalia ASPG 33 34
  • 85.58 (n)
(Canis familiaris)
Mammalia ASPG 33 34
  • 83.43 (n)
(Mus musculus)
Mammalia Aspg 33 16 34
  • 80.38 (n)
(Rattus norvegicus)
Mammalia Aspg 33
  • 79.79 (n)
(Monodelphis domestica)
Mammalia ASPG 34
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia ASPG 34
  • 65 (a)
(Gallus gallus)
Aves ASPG 34
  • 49 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 50 (a)
-- 34
  • 39 (a)
(Danio rerio)
Actinopterygii aspg 34
  • 43 (a)
ASPG (3 of 3) 34
  • 23 (a)
ASPG (2 of 3) 34
  • 15 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6428 34
  • 36 (a)
CG8526 34
  • 33 (a)
(Caenorhabditis elegans)
Secernentea C27A7.5 34
  • 30 (a)
Species where no ortholog for ASPG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ASPG Gene

Gene Tree for ASPG (if available)
Gene Tree for ASPG (if available)

Paralogs for ASPG Gene

(4) SIMAP similar genes for ASPG Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ASPG: view

No data available for Paralogs for ASPG Gene

Variants for ASPG Gene

Sequence variations from dbSNP and Humsavar for ASPG Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000076238 -- 104,095,963(+) CTCCC(A/G)ATGCT intron-variant
rs1000083959 -- 104,083,756(+) GATGC(A/G)TGACT upstream-variant-2KB, utr-variant-3-prime
rs1000122555 -- 104,087,809(+) TCGCC(A/G)CAGCA intron-variant
rs1000189389 -- 104,084,580(+) AAGCG(G/T)CTCAA upstream-variant-2KB
rs1000282521 -- 104,108,260(+) GGGGG(C/T)GGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ASPG Gene

Variant ID Type Subtype PubMed ID
nsv952262 CNV deletion 24416366
nsv566031 CNV loss 21841781
nsv566030 CNV gain 21841781
nsv566029 CNV loss 21841781
nsv526680 CNV gain 19592680
nsv519605 CNV loss 19592680
nsv470674 CNV loss 18288195
nsv1071175 CNV deletion 25765185
nsv1054574 CNV loss 25217958
nsv1050479 CNV gain 25217958
nsv1047990 CNV gain 25217958
esv3635616 CNV gain 21293372
esv3635614 CNV gain 21293372
esv2749189 CNV deletion 23290073
esv2749183 CNV deletion 23290073
esv2749181 CNV deletion 23290073
esv2749180 CNV deletion 23290073
esv2749179 CNV deletion 23290073
dgv277e201 CNV deletion 23290073
dgv276e201 CNV deletion 23290073

Variation tolerance for ASPG Gene

Residual Variation Intolerance Score: 89.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.97; 95.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ASPG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASPG Gene

Disorders for ASPG Gene

Relevant External Links for ASPG

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ASPG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASPG Gene

Publications for ASPG Gene

  1. Human 60-kDa lysophospholipase contains an N-terminal L-asparaginase domain that is allosterically regulated by L-asparagine. (PMID: 24657844) Karamitros CS … Konrad M (The Journal of biological chemistry 2014) 3 60
  2. Elucidation of the specific function of the conserved threonine triad responsible for human L-asparaginase autocleavage and substrate hydrolysis. (PMID: 24768817) Nomme J … Lavie A (Journal of molecular biology 2014) 3 60
  3. An atlas of genetic influences on human blood metabolites. (PMID: 24816252) Shin SY … Soranzo N (Nature genetics 2014) 3 60
  4. Structures of apo and product-bound human L-asparaginase: insights into the mechanism of autoproteolysis and substrate hydrolysis. (PMID: 22861376) Nomme J … Lavie A (Biochemistry 2012) 3 60
  5. 60kDa lysophospholipase, a new Sgk1 molecular partner involved in the regulation of ENaC. (PMID: 21063096) Menniti M … Perrotti N (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2010) 3 60

Products for ASPG Gene

Sources for ASPG Gene

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