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Aliases for ASPG Gene

Aliases for ASPG Gene

  • Asparaginase 2 3 5
  • 60-KDa-Lysophospholipase 2 3
  • C14orf76 3 4
  • Asparaginase Homolog (S. Cerevisiae) 2
  • Chromosome 14 Open Reading Frame 76 2
  • Wild-Type L-Asparaginase 3
  • Asparaginase Homolog 3
  • EC 3.1.1.5 4
  • GPA/WT 3

External Ids for ASPG Gene

Previous HGNC Symbols for ASPG Gene

  • C14orf76

Previous GeneCards Identifiers for ASPG Gene

  • GC14P103622
  • GC14P104552
  • GC14P084732

Summaries for ASPG Gene

GeneCards Summary for ASPG Gene

ASPG (Asparaginase) is a Protein Coding gene. Among its related pathways are Amino acid synthesis and interconversion (transamination) and Viral mRNA Translation. GO annotations related to this gene include lysophospholipase activity and asparaginase activity.

UniProtKB/Swiss-Prot for ASPG Gene

  • Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASPG Gene

Genomics for ASPG Gene

Regulatory Elements for ASPG Gene

Enhancers for ASPG Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ASPG on UCSC Golden Path with GeneCards custom track

Genomic Location for ASPG Gene

Chromosome:
14
Start:
104,085,670 bp from pter
End:
104,115,581 bp from pter
Size:
29,912 bases
Orientation:
Plus strand

Genomic View for ASPG Gene

Genes around ASPG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASPG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASPG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASPG Gene

Proteins for ASPG Gene

  • Protein details for ASPG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86U10-LPP60_HUMAN
    Recommended name:
    60 kDa lysophospholipase
    Protein Accession:
    Q86U10
    Secondary Accessions:
    • B9EGQ2
    • Q8IV80

    Protein attributes for ASPG Gene

    Size:
    573 amino acids
    Molecular mass:
    60883 Da
    Quaternary structure:
    • Monomer.
    SequenceCaution:
    • Sequence=CAD62331.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Alternative splice isoforms for ASPG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASPG Gene

Proteomics data for ASPG Gene at MOPED

Post-translational modifications for ASPG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ASPG Gene

No data available for DME Specific Peptides for ASPG Gene

Domains & Families for ASPG Gene

Gene Families for ASPG Gene

Suggested Antigen Peptide Sequences for ASPG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86U10

UniProtKB/Swiss-Prot:

LPP60_HUMAN :
  • Contains 1 asparaginase/glutaminase domain.
  • In the N-terminal section; belongs to the asparaginase 1 family.
  • Contains 5 ANK repeats.
Domain:
  • Contains 1 asparaginase/glutaminase domain.
Family:
  • In the N-terminal section; belongs to the asparaginase 1 family.
Similarity:
  • Contains 5 ANK repeats.
genes like me logo Genes that share domains with ASPG: view

Function for ASPG Gene

Molecular function for ASPG Gene

UniProtKB/Swiss-Prot CatalyticActivity:
2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate.
UniProtKB/Swiss-Prot CatalyticActivity:
L-asparagine + H(2)O = L-aspartate + NH(3).
UniProtKB/Swiss-Prot CatalyticActivity:
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H(2)O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.
UniProtKB/Swiss-Prot Function:
Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities.

Enzyme Numbers (IUBMB) for ASPG Gene

Gene Ontology (GO) - Molecular Function for ASPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004622 lysophospholipase activity IEA --
genes like me logo Genes that share ontologies with ASPG: view

Phenotypes for ASPG Gene

genes like me logo Genes that share phenotypes with ASPG: view

Animal Model Products

CRISPR Products

miRNA for ASPG Gene

miRTarBase miRNAs that target ASPG

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ASPG Gene

Localization for ASPG Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ASPG Gene COMPARTMENTS Subcellular localization image for ASPG gene
Compartment Confidence
cytosol 3
mitochondrion 3
extracellular 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ASPG Gene

Pathways & Interactions for ASPG Gene

genes like me logo Genes that share pathways with ASPG: view

Pathways by source for ASPG Gene

Gene Ontology (GO) - Biological Process for ASPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008652 cellular amino acid biosynthetic process TAS --
genes like me logo Genes that share ontologies with ASPG: view

No data available for SIGNOR curated interactions for ASPG Gene

Drugs & Compounds for ASPG Gene

(8) Drugs for ASPG Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
acetic acid Approved Nutra Full agonist, Agonist 97
L-Asparagine Approved Nutra 0
L-Aspartic acid Approved Nutra NMDA agonist 0
MYRISTIC ACID Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 22

(42) Additional Compounds for ASPG Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ammonia
  • Ammonia anhydrous
  • Ammonia inhalant
  • Ammonia solution strong [usan]
  • Ammonia water
  • Ammoniak
7664-41-7
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
506-30-9
glycerophosphocholine
  • 2-[[(2,3-Dihydroxypropoxy)hydroxyphosphinyl]oxy]-N,N,N-trimethyl-Ethanaminium inner salt
  • a-Glycerophosphorylcholine
  • a-Glycerylphosphorylcholine
  • alpha-Glycerophosphorylcholine
  • alpha-Glycerylphosphorylcholine
28319-77-9
Heptadecanoic acid
  • Heptadecanoate
  • Heptadecanoic acid
  • Margarate
  • Margaric acid
  • Margarinate
506-12-7
Heptadecanoyl CoA
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid coa
  • Heptadecanoyl coenzyme A
  • Heptadecanoyl-coA
3546-17-6
genes like me logo Genes that share compounds with ASPG: view

Transcripts for ASPG Gene

Unigene Clusters for ASPG Gene

Asparaginase homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ASPG Gene

No ASD Table

Relevant External Links for ASPG Gene

GeneLoc Exon Structure for
ASPG
ECgene alternative splicing isoforms for
ASPG

Expression for ASPG Gene

mRNA expression in normal human tissues for ASPG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ASPG Gene

This gene is overexpressed in Liver (x20.2) and Heart - Atrial Appendage (x14.1).

Protein differential expression in normal tissues from HIPED for ASPG Gene

This gene is overexpressed in Liver (28.3), Kidney (16.1), Gallbladder (11.1), and Esophagus (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ASPG Gene



SOURCE GeneReport for Unigene cluster for ASPG Gene Hs.146239

genes like me logo Genes that share expression patterns with ASPG: view

Protein tissue co-expression partners for ASPG Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ASPG Gene

Orthologs for ASPG Gene

This gene was present in the common ancestor of animals.

Orthologs for ASPG Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ASPG 35
  • 85.58 (n)
  • 81.44 (a)
ASPG 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ASPG 35
  • 83.43 (n)
  • 81.35 (a)
ASPG 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aspg 35
  • 80.38 (n)
  • 79.96 (a)
Aspg 16
Aspg 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ASPG 35
  • 98.37 (n)
  • 98.08 (a)
ASPG 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aspg 35
  • 79.79 (n)
  • 79.26 (a)
oppossum
(Monodelphis domestica)
Mammalia ASPG 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ASPG 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves ASPG 36
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 50 (a)
OneToMany
-- 36
  • 39 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii aspg 36
  • 43 (a)
OneToMany
ASPG (2 of 3) 36
  • 15 (a)
OneToMany
ASPG (3 of 3) 36
  • 23 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6428 36
  • 36 (a)
OneToMany
CG8526 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C27A7.5 36
  • 30 (a)
OneToOne
Species with no ortholog for ASPG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ASPG Gene

ENSEMBL:
Gene Tree for ASPG (if available)
TreeFam:
Gene Tree for ASPG (if available)

Paralogs for ASPG Gene

(4) SIMAP similar genes for ASPG Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ASPG: view

No data available for Paralogs for ASPG Gene

Variants for ASPG Gene

Sequence variations from dbSNP and Humsavar for ASPG Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1770984 - 104,093,582(-) AAGGC(A/G)AACCC nc-transcript-variant, reference, missense
rs1744284 - 104,093,585(+) TTTGC(C/G)TTGCC nc-transcript-variant, reference, missense
rs8012505 - 104,104,717(+) CTGAG(C/G/T)CTGGA nc-transcript-variant, reference, missense
rs1465163 -- 104,097,595(-) CCCAG(A/C)AGGTT nc-transcript-variant, reference, synonymous-codon
rs1467844 -- 104,103,372(-) CGGCC(C/T)GTGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ASPG Gene

Variant ID Type Subtype PubMed ID
nsv902319 CNV Gain 21882294
nsv526680 CNV Gain 19592680
dgv1998n71 CNV Loss 21882294
dgv1999n71 CNV Loss 21882294
nsv470674 CNV Loss 18288195
dgv2000n71 CNV Loss 21882294
dgv2001n71 CNV Loss 21882294
nsv902336 CNV Loss 21882294
nsv902339 CNV Gain 21882294
nsv519605 CNV Loss 19592680
esv2749179 CNV Deletion 23290073
esv2749180 CNV Deletion 23290073
nsv902350 CNV Loss 21882294
esv2749181 CNV Deletion 23290073
dgv303e201 CNV Deletion 23290073
esv2749183 CNV Deletion 23290073
dgv304e201 CNV Deletion 23290073
esv2749189 CNV Deletion 23290073

Variation tolerance for ASPG Gene

Residual Variation Intolerance Score: 89.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.97; 95.99% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ASPG Gene

Disorders for ASPG Gene

Relevant External Links for ASPG

Genetic Association Database (GAD)
ASPG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ASPG

No disorders were found for ASPG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASPG Gene

Publications for ASPG Gene

  1. An atlas of genetic influences on human blood metabolites. (PMID: 24816252) Shin S.Y. … Soranzo N. (Nat. Genet. 2014) 3 67
  2. Human 60-kDa lysophospholipase contains an N-terminal L-asparaginase domain that is allosterically regulated by L-asparagine. (PMID: 24657844) Karamitros C.S. … Konrad M. (J. Biol. Chem. 2014) 3
  3. Elucidation of the specific function of the conserved threonine triad responsible for human L-asparaginase autocleavage and substrate hydrolysis. (PMID: 24768817) Nomme J. … Lavie A. (J. Mol. Biol. 2014) 3
  4. Structures of apo and product-bound human L-asparaginase: insights into the mechanism of autoproteolysis and substrate hydrolysis. (PMID: 22861376) Nomme J. … Lavie A. (Biochemistry 2012) 3
  5. 60kDa lysophospholipase, a new Sgk1 molecular partner involved in the regulation of ENaC. (PMID: 21063096) Menniti M. … Perrotti N. (Cell. Physiol. Biochem. 2010) 3

Products for ASPG Gene

Sources for ASPG Gene

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