Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ASPG Gene

protein-coding   GIFtS: 50
GCID: GC14P104552

Asparaginase

(Previous names: chromosome 14 open reading frame 76, asparaginase homolog...)
(Previous symbol: C14orf76)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
asparaginase1 2     Asparaginase Homolog2
C14orf761 2 3     Wild-Type L-Asparaginase2
60-kDa-lysophospholipase1 2     EC 3.1.1.53
Asparaginase Homolog (S. Cerevisiae)1     ASPGX15
Chromosome 14 Open Reading Frame 761     AUTSX15
60 KDa Lysophospholipase2     NLGN35
GPA/WT2     

External Ids:    HGNC: 201231   Entrez Gene: 3745692   Ensembl: ENSG000001661837   OMIM: 3003365   UniProtKB: Q86U103   

Export aliases for ASPG gene to outside databases

Previous GC identifers: GC14P103622 GC14P084732


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for ASPG Gene:
ASPG (asparaginase) is a protein-coding gene. GO annotations related to this gene include asparaginase activity and lysophospholipase activity.

UniProtKB/Swiss-Prot: LPP60_HUMAN, Q86U10
Function: Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ASPG gene promoter:
         FOXF2   NRSF form 1   ATF-2   NRSF form 2   LCR-F1   HNF-4alpha1   CREB   CRE-BP1   deltaCREB   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidASPG promoter sequence
   Search Chromatin IP Primers for ASPG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ASPG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.33

ASPG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASPG gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P104552:  view genomic region     (about GC identifiers)

Start:
104,552,016 bp from pter      End:
104,579,098 bp from pter
Size:
27,083 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: LPP60_HUMAN, Q86U10 (See protein sequence)
Recommended Name: 60 kDa lysophospholipase  
Size: 573 amino acids; 60883 Da
Subunit: Monomer (By similarity)
Sequence caution: Sequence=CAD62331.1; Type=Erroneous translation; Note=Wrong choice of frame;
Secondary accessions: B9EGQ2 Q8IV80
Alternative splicing: 2 isoforms:  Q86U10-1   Q86U10-3   (May be due to a competing acceptor splice site)

Explore the universe of human proteins at neXtProt for ASPG: NX_Q86U10

Explore proteomics data for ASPG at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ASPG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001073933.2  
    ENSEMBL proteins: 
     ENSP00000450040   ENSP00000448911   ENSP00000447032   ENSP00000446856   ENSP00000389003  

    ASPG Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ASPG
    OriGene Protein Over-expression Lysate for ASPG
    OriGene MassSpec for ASPG
    OriGene Custom Protein Services for ASPG
    GenScript Custom Purified and Recombinant Proteins Services for ASPG
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ASPG

     
    Search eBioscience for Proteins for ASPG 

     
    antibodies-online proteins for ASPG (3 products) 

     
    antibodies-online peptides for ASPG

    ASPG Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ASPG
    Abcam antibodies for ASPG
    Cloud-Clone Corp. Antibodies for ASPG
    Search ThermoFisher Antibodies for ASPG
    antibodies-online antibodies for ASPG (24 products) 

    ASPG Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ASPG
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ASPG
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ASPG
    Cloud-Clone Corp. CLIAs for ASPG
    Search eBioscience for ELISAs for ASPG 
    antibodies-online kits for ASPG (7 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing

    Selected InterPro protein domains (see all 7):
     IPR027473 L-asparaginase_C
     IPR027474 L-asparaginase_N
     IPR006033 AsnASEI
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q86U10

    ProtoNet protein and cluster: Q86U10

    1 Blocks protein domain: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: LPP60_HUMAN, Q86U10
    Similarity: In the N-terminal section; belongs to the asparaginase 1 family
    Similarity: Contains 5 ANK repeats


    Find genes that share domains with ASPG           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LPP60_HUMAN, Q86U10
    Function: Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities
    Catalytic activity: 2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate
    Catalytic activity: L-asparagine + H(2)O = L-aspartate + NH(3)
    Catalytic activity: 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H(2)O = 1-alkyl-sn-glycero-3-phosphocholine +
    acetate

         Enzyme Number (IUBMB): EC 3.1.1.51

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00038471-alkyl-2-acetylglycerophosphocholine esterase activity IEA--
    GO:0004067asparaginase activity IEA--
    GO:0004622lysophospholipase activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with ASPG           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ASPG

    miRNA
    Products:
        
    miRTarBase miRNAs that target ASPG:
    hsa-mir-335-5p (MIRT018153)

    Block miRNA regulation of human, mouse, rat ASPG using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ASPG
    SwitchGear 3'UTR luciferase reporter plasmidASPG 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ASPG
    Predesigned siRNA for gene silencing in human, mouse, rat ASPG

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ASPG

    Clone
    Products:
         
    OriGene clones in human, mouse for ASPG (see all 5)
    OriGene ORF clones in mouse, rat for ASPG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ASPG (NM_001080464)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ASPG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASPG

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ASPG
    Browse ESI BIO Cell Lines and PureStem Progenitors for ASPG 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASPG


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    mitochondrion3
    vacuole1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ASPG About    
    See pathways by source

    SuperPathContained pathways About
    1asparagine degradation I
    asparagine degradation I


    1 BioSystems Pathway for ASPG
        asparagine degradation I


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ASPG
    Interactions:

        Search GeneGlobe Interaction Network for ASPG

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for ASPG (ENSP000003890034) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VCPENSP000003517774STRING: ENSP00000351777
    EIF4BENSP000002620564STRING: ENSP00000262056
    ZC3H14ENSP000002510384STRING: ENSP00000251038
    PTGES3ENSP000002620334STRING: ENSP00000262033
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006520cellular amino acid metabolic process ----
    GO:0006528asparagine metabolic process IEA--
    GO:0006644phospholipid metabolic process IEA--
    GO:0016042lipid catabolic process IEA--

    Find genes that share ontologies with ASPG           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ASPG (LPP60)

    Selected HMDB Compounds for ASPG (see all 46)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Arachidic acidArachate (see all 10)506-30-9--
    Arachidonic acid5,8,11,14-Eicosatetraenoic acid (see all 16)506-32-1--
    Glycerophosphocholine2-[[(2,3-dihydroxypropoxy)hydroxyphosphinyl]oxy]-N,N,N-trimethyl-Ethanaminium inner salt (see all 21)28319-77-9--
    Heptadecanoic acidHeptadecanoate (see all 16)506-12-7--
    Heptadecanoyl CoAHeptadecanoyl coenzyme A (see all 19)3546-17-6--
    L-Asparagine(-)-Asparagine (see all 32)70-47-3--
    LysoPC(0:0/18:0)1-Hydroxy-2-stearoyl-sn-glycero-3-phosphocholine (see all 4)----
    LysoPC(10:0)1-Decanoyllysolecithin (see all 14)22248-63-1--
    LysoPC(14:0)LysoPC(14:0) (see all 9)----
    LysoPC(14:1(9Z))LysoPC(14:1) (see all 17)----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ASPG gene: 
    NM_001080464.2  

    Unigene Cluster for ASPG:

    Asparaginase homolog (S. cerevisiae)
    Hs.146239  [show with all ESTs]
    Unigene Representative Sequence: NM_001080464
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000551177(uc001yop.2 uc001yoq.2 uc001yor.2) ENST00000548372(uc001yoo.2)
    ENST00000546892 ENST00000551170 ENST00000549809 ENST00000552126 ENST00000556267
    ENST00000550583 ENST00000551871 ENST00000455920
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ASPG using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ASPG
    SwitchGear 3'UTR luciferase reporter plasmidASPG 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ASPG
    Predesigned siRNA for gene silencing in human, mouse, rat ASPG
    Clone
    Products:
         
    OriGene clones in human, mouse for ASPG (see all 5)
    OriGene ORF clones in mouse, rat for ASPG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ASPG (NM_001080464)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ASPG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASPG
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ASPG
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ASPG
      QuantiTect SYBR Green Assays in human, mouse, rat ASPG
      QuantiFast Probe-based Assays in human, mouse, rat ASPG

    Additional mRNA sequence: 

    BC035836.1 BC136637.1 

    6 DOTS entries:

    DT.40267311  DT.100835622  DT.75101104  DT.75185120  DT.91753118  DT.95363552 

    Selected AceView cDNA sequences (see all 37):

    AI264819 BC035836 CA841092 BX282189 BX280385 BX247999 AI090540 BE464276 
    AW304444 AW024833 AI436722 AA700625 AX781428 AX781435 BX410108 AW084572 
    AW269191 BX407951 AX781430 AX781433 BX414463 BX106433 BM544197 AW025309 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ASPG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTCAGGAA
    ASPG Expression
    About this image


    ASPG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Thoracic Perivascular Adipose
    ASPG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ASPG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.146239
        Custom PCR Arrays for ASPG
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ASPG
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ASPG
    QuantiTect SYBR Green Assays in human, mouse, rat ASPG
    QuantiFast Probe-based Assays in human, mouse, rat ASPG
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASPG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for ASPG gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aspg1 , 5 asparaginase homolog (S. cerevisiae)1, 5 80.38(n)1
    79.96(a)1
      12 (61.14 cM)5
    1048161  NM_001081169.11  NP_001074638.11 
     1121066835 
    chicken
    (Gallus gallus)
    Aves ASPG6
    asparaginase homolog (S. cerevisiae)
    49(a)
    1 ↔ 1
    5(50534850-50582291)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    50(a)
    39(a)
    many → 1
    many → 1
    1(5642332-5731139)
    1(5744416-5763225)
    zebrafish
    (Danio rerio)
    Actinopterygii aspg6
    ASPG (3 of 3)6
    (see all 3)
    asparaginase homolog (S. cerevisiae)
    (see all 3)
    43(a)
    23(a)
    (see all 3)
    many → 1
    many → 1
    (see all 3)
    17(45905508-45942116) ENSDARG00000052942
    5(64399400-64411678) ENSDARG00000093734
    fruit fly
    (Drosophila melanogaster)
    Insecta CG64286
    CG85266
    --
    36(a)
    33(a)
    many → 1
    many → 1
    X(3859459-3862597)
    3R(5627008-5629183)
    worm
    (Caenorhabditis elegans)
    Secernentea C27A7.56
    Protein C27A7.5, isoform a
    30(a)
    1 ↔ 1
    V(12154875-12162299) WBGene00007756


    ENSEMBL Gene Tree for ASPG (if available)
    TreeFam Gene Tree for ASPG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ASPG gene
    4 SIMAP similar genes for ASPG using alignment to 4 protein entries:     LPP60_HUMAN (see all proteins):
    PPP1R12A    PSMD10    DKFZp761E1322    MTPN

    Find genes that share paralogs with ASPG           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ASPG (see all 713)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1834892121,2
    --104550052(+) CTATAA/GAAAGA 1 -- us2k10--------
    rs1441131461,2
    --104550164(+) ACCAAC/TCTGTG 1 -- us2k10--------
    rs1464851561,2
    --104550262(+) CAGAAA/GACTAA 1 -- us2k10--------
    rs1409477101,2
    C--104550372(+) CATGGC/TGGCTC 1 -- us2k10--------
    rs17442751,2
    C,A--104550468(+) GAAACC/TCCGTC 1 -- us2k10--------
    rs17442761,2
    C,A--104550471(+) ACCCCC/GTCTCT 1 -- us2k10--------
    rs574287741,2
    C,F--104550487(+) AAAAA-/A/AA  
            
    GAAAA
    1 -- us2k12NA CSA 4
    rs1823237911,2
    --104550544(+) CCCAGC/TTATTC 1 -- us2k10--------
    rs1149940951,2
    F--104550550(+) TATTCG/AGGGAG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1175815391,2
    C,F--104550688(+) GCCTTC/TTGGGG 1 -- us2k12Minor allele frequency- T:0.01NA EA 240

    HapMap Linkage Disequilibrium report for ASPG (104552016 - 104579098 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ASPG (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv303e201CNV Deletion23290073
    esv2749183CNV Deletion23290073
    esv2749189CNV Deletion23290073
    esv2749180CNV Deletion23290073
    dgv304e201CNV Deletion23290073
    esv2749181CNV Deletion23290073
    esv2749179CNV Deletion23290073
    nsv902336CNV Loss21882294
    dgv2000n71CNV Loss21882294
    nsv470674CNV Loss18288195

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ASPG
    DNA2.0 Custom Variant and Variant Library Synthesis for ASPG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 300336   
    OMIM disorders: 300425  300494  

    Find genes that share disorders with ASPG           About GenesLikeMe

    Genetic Association Database (GAD): ASPG

    Export disorders for ASPG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ASPG gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ASPG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structures of apo and product-bound human L-asparaginase: insights into the mechanism of autoproteolysis and substrate hydrolysis. (PubMed id 22861376)1 Nomme J.... Lavie A. (Biochemistry 2012)
    2. 60kDa lysophospholipase, a new Sgk1 molecular partner involved in the regulation of ENaC. (PubMed id 21063096)1 Menniti M....Perrotti N. (Cell. Physiol. Biochem. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (Nature 2003)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 374569 HGNC: 20123 AceView: LOC374569 Ensembl:ENSG00000166183 euGenes: HUgn374569
    ECgene: ASPG H-InvDB: ASPG

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ASPG Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ASPG gene:
    Search GeneIP for patents involving ASPG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ASPG  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for ASPG  
     OriGene MassSpec for ASPG   OriGene clones in human, mouse for ASPG  
     OriGene qSTAR qPCR primer pairs in human, mouse for ASPG   OriGene Purified Protein for ASPG  
     OriGene ORF clones in mouse, rat for ASPG   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ASPG   OriGene Custom Protein Services for ASPG  

     
     
     Block miRNA regulation of human, mouse, rat ASPG using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ASPG
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ASPG Predesigned siRNA for gene silencing in human, mouse, rat ASPG
     QuantiFast Probe-based Assays in human, mouse, rat ASPG QuantiTect SYBR Green Assays in human, mouse, rat ASPG
     Custom PCR Arrays for ASPG Search Chromatin IP Primers for ASPG
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ASPG  Search GeneGlobe Interaction Network for ASPG
     Regulatory tfbs in ASPG promoter
     GenScript Custom Purified and Recombinant Proteins Services for ASPG GenScript cDNA clones with any tag delivered in your preferred vector for ASPG
     GenScript Custom Assay Services for ASPG GenScript Custom overexpressing Cell Line Services for ASPG
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ASPG (LPP60)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Biologicals
     Novus Tissue Slides
     Antibodies for ASPG
     See all of Abcam's Antibodies, Kits and Proteins for ASPG
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ASPG
     Antibodies for ASPG
     ELISAs for ASPG
     CLIAs for ASPG



     Browse ESI BIO Cell Lines and PureStem Progenitors for ASPG
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASPG
     SwitchGear 3'UTR luciferase reporter plasmids for ASPG
     SwitchGear Promoter luciferase reporter plasmids for ASPG
     Search ThermoFisher Antibodies for ASPG
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASPG
     Browse compounds at ApexBio
     Search Addgene for plasmids for ASPG
      Search eBioscience for proteins for ASPG
      Search eBioscience for elisas for ASPG
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for ASPG
     antibodies-online antibodies for ASPG (24 products)
     antibodies-online kits for ASPG (7 products)
     antibodies-online peptides for ASPG
     antibodies-online proteins for ASPG (3 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ASPG gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4