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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ASPG Gene

protein-coding   GIFtS: 46
GCID: GC14P104552

Asparaginase Homolog (S. Cerevisiae)

(Previous name: chromosome 14 open reading frame 76)
(Previous symbol: C14orf76)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Asparaginase Homolog (S. Cerevisiae)1 2     GPA/WT2
C14orf761 2 3     Wild-Type L-Asparaginase2
Chromosome 14 Open Reading Frame 761     EC 3.1.1.53
60 KDa Lysophospholipase2     

External Ids:    HGNC: 201231   Entrez Gene: 3745692   Ensembl: ENSG000001661837   UniProtKB: Q86U103   

Export aliases for ASPG gene to outside databases

Previous GC identifers: GC14P103622 GC14P084732


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ASPG Gene: 
ASPG (asparaginase homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with ASPG include nasopharynx carcinoma, and cystadenoma. GO annotations related to this gene include asparaginase activity and lysophospholipase activity.

UniProtKB/Swiss-Prot: LPP60_HUMAN, Q86U10
Function: Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ASPG gene promoter:
         FOXF2   NRSF form 1   ATF-2   NRSF form 2   LCR-F1   HNF-4alpha1   CREB   CRE-BP1   deltaCREB   c-Myb   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ASPG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASPG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.33

ASPG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASPG gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P104552:  view genomic region     (about GC identifiers)

Start:
104,552,016 bp from pter      End:
104,579,098 bp from pter
Size:
27,083 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LPP60_HUMAN, Q86U10 (See protein sequence)
Recommended Name: 60 kDa lysophospholipase  
Size: 573 amino acids; 60883 Da
Subunit: Monomer (By similarity)
Sequence caution: Sequence=CAD62331.1; Type=Erroneous translation; Note=Wrong choice of frame;
Secondary accessions: B9EGQ2 Q8IV80
Alternative splicing: 2 isoforms:  Q86U10-1   Q86U10-3   (May be due to a competing acceptor splice site)

Explore the universe of human proteins at neXtProt for ASPG: NX_Q86U10

Explore proteomics data for ASPG at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86U10

  • ASPG Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ASPG Protein Expression
    REFSEQ proteins: NP_001073933.2  
    ENSEMBL proteins: 
     ENSP00000450040   ENSP00000448911   ENSP00000447032   ENSP00000446856   ENSP00000389003  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ANKRD: Ankyrin repeat domain containing

    5/7 InterPro protein domains (see all 7):
     IPR027473 L-asparaginase_C
     IPR027474 L-asparaginase_N
     IPR020683 Ankyrin_rpt-contain_dom
     IPR006034 Asparaginase/glutaminase
     IPR006033 AsnASEI

    Graphical View of Domain Structure for InterPro Entry Q86U10

    ProtoNet protein and cluster: Q86U10

    1 Blocks protein domain: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: LPP60_HUMAN, Q86U10
    Similarity: In the N-terminal section; belongs to the asparaginase 1 family
    Similarity: Contains 5 ANK repeats


    ASPG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LPP60_HUMAN, Q86U10
    Function: Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities
    Catalytic activity: 2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate
    Catalytic activity: L-asparagine + H(2)O = L-aspartate + NH(3)
    Catalytic activity: 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H(2)O = 1-alkyl-sn-glycero-3-phosphocholine +
    acetate

         Enzyme Number (IUBMB): EC 3.1.1.51

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00038471-alkyl-2-acetylglycerophosphocholine esterase activity IEA--
    GO:0004067asparaginase activity IEA--
    GO:0004622lysophospholipase activity IEA--
    GO:0005515protein binding ----
         
    ASPG for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ASPG 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ASPG About                                                                                                See pathways by source

    SuperPathContained pathways About
    1asparagine degradation I
    asparagine degradation I


    1 BioSystems Pathway for ASPG
        asparagine degradation I


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ASPG

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006520cellular amino acid metabolic process ----
    GO:0006528asparagine metabolic process IEA--
    GO:0006644phospholipid metabolic process IEA--
    GO:0016042lipid catabolic process IEA--

    ASPG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ASPG (LPP60)

    10/46 HMDB Compounds for ASPG (see all 46)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Arachidic acidArachate (see all 10)506-30-9--
    Arachidonic acid5,8,11,14-Eicosatetraenoic acid (see all 16)506-32-1--
    Glycerophosphocholine2-[[(2,3-dihydroxypropoxy)hydroxyphosphinyl]oxy]-N,N,N-trimethyl-Ethanaminium inner salt (see all 21)28319-77-9--
    Heptadecanoic acidHeptadecanoate (see all 16)506-12-7--
    Heptadecanoyl CoAHeptadecanoyl coenzyme A (see all 19)3546-17-6--
    L-Asparagine(-)-Asparagine (see all 32)70-47-3--
    LysoPC(0:0/18:0)1-Hydroxy-2-stearoyl-sn-glycero-3-phosphocholine (see all 4)----
    LysoPC(10:0)1-Decanoyllysolecithin (see all 14)22248-63-1--
    LysoPC(14:0)LysoPC(14:0) (see all 9)----
    LysoPC(14:1(9Z))LysoPC(14:1) (see all 17)----

    Search CenterWatch for drugs/clinical trials and news about ASPG / LPP60

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ASPG gene: 
    NM_001080464.2  

    Unigene Cluster for ASPG:

    Asparaginase homolog (S. cerevisiae)
    Hs.146239  [show with all ESTs]
    Unigene Representative Sequence: NM_001080464
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000551177(uc001yop.2 uc001yoq.2 uc001yor.2) ENST00000548372(uc001yoo.2)
    ENST00000546892 ENST00000551170 ENST00000549809 ENST00000552126 ENST00000556267
    ENST00000550583 ENST00000551871 ENST00000455920
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASPG

    Additional mRNA sequence: 

    BC035836.1 BC136637.1 

    6 DOTS entries:

    DT.40267311  DT.100835622  DT.75101104  DT.75185120  DT.91753118  DT.95363552 

    24/37 AceView cDNA sequences (see all 37):

    AI090540 BC035836 AW024833 CA841092 AI436722 BX247999 BX282189 AW304444 
    AI264819 BX280385 BE464276 AX781435 BM544197 AW084572 AX781430 BX106433 
    AX781428 BX410108 AX781429 BX414463 BX407951 BM543773 AW025309 AX781431 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ASPG expression in normal human tissues (normalized intensities)      ASPG embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTCAGGAA
    ASPG Expression
    About this image


    ASPG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Thoracic Perivascular Adipose
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...

    See ASPG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ASPG

    SOURCE GeneReport for Unigene cluster: Hs.146239
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ASPG gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aspg1 , 5 asparaginase homolog (S. cerevisiae)1, 5 80.71(n)1
    80.18(a)1
      12 (61.14 cM)5
    1048161  NM_001081169.11  NP_001074638.11 
     1121066835 
    chicken
    (Gallus gallus)
    Aves ASPG6
    asparaginase homolog (S. cerevisiae)
    49(a)
    1 ↔ 1
    5(50534850-50582291)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    49(a)
    39(a)
    many → 1
    many → 1
    1(5642332-5731139)
    1(5744416-5763225)
    zebrafish
    (Danio rerio)
    Actinopterygii aspg6
    si:ch211-209a2.26
    (see all 3)
    si:ch211-209a2.2
    (see all 3)
    43(a)
    26(a)
    (see all 3)
    1 ↔ 1
    possible ortholog
    (see all 3)
    17(45905508-45942116)
    5(64399400-64411678)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG64286
    CG85266
    --
    38(a)
    36(a)
    many → 1
    many → 1
    X(3859459-3862597)
    3R(5627008-5629183)
    worm
    (Caenorhabditis elegans)
    Secernentea C27A7.56
    Protein C27A7.5, isoform d
    32(a)
    1 ↔ 1
    V(12154875-12162299)


    ENSEMBL Gene Tree for ASPG (if available)
    TreeFam Gene Tree for ASPG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ASPG gene
    4 SIMAP similar genes for ASPG using alignment to 4 protein entries:     LPP60_HUMAN (see all proteins):
    PPP1R12A    PSMD10    DKFZp761E1322    MTPN

    ASPG for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/713 SNPs in ASPG are shown (see all 713)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1834892121,2
    --104550052(+) CTATAA/GAAAGA 1 -- us2k10--------
    rs1441131461,2
    --104550164(+) ACCAAC/TCTGTG 1 -- us2k10--------
    rs1464851561,2
    --104550262(+) CAGAAA/GACTAA 1 -- us2k10--------
    rs1409477101,2
    C--104550372(+) CATGGC/TGGCTC 1 -- us2k10--------
    rs17442751,2
    C,A--104550468(+) GAAACC/TCCGTC 1 -- us2k10--------
    rs17442761,2
    C,A--104550471(+) ACCCCC/GTCTCT 1 -- us2k10--------
    rs574287741,2
    C,F--104550487(+) AAAAA-/A/AA  
            
    GAAAA
    1 -- us2k12NA CSA 4
    rs1823237911,2
    --104550544(+) CCCAGC/TTATTC 1 -- us2k10--------
    rs1149940951,2
    F--104550550(+) TATTCG/AGGGAG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1175815391,2
    C,F--104550688(+) GCCTTC/TTGGGG 1 -- us2k12Minor allele frequency- T:0.01NA EA 240

    HapMap Linkage Disequilibrium report for ASPG (104552016 - 104579098 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/18 variations for ASPG (see all 18):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv303e201CNV Deletion23290073
    esv2749183CNV Deletion23290073
    esv2749189CNV Deletion23290073
    esv2749180CNV Deletion23290073
    dgv304e201CNV Deletion23290073
    esv2749181CNV Deletion23290073
    esv2749179CNV Deletion23290073
    nsv902336CNV Loss21882294
    dgv2000n71CNV Loss21882294
    nsv470674CNV Loss18288195

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    3 diseases for ASPG:    About MalaCards
    nasopharynx carcinoma    cystadenoma    pneumonia


    ASPG for disorders           About GeneDecksing

    Genetic Association Database (GAD): ASPG

    Export disorders for ASPG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ASPG gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ASPG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structures of apo and product-bound human L-asparaginase: insights into the mechanism of autoproteolysis and substrate hydrolysis. (PubMed id 22861376)1 Nomme J.... Lavie A. (2012)
    2. 60kDa lysophospholipase, a new Sgk1 molecular partner involved in the regulation of ENaC. (PubMed id 21063096)1 Menniti M....Perrotti N. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (2003)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 374569 HGNC: 20123 AceView: LOC374569 Ensembl:ENSG00000166183 euGenes: HUgn374569
    ECgene: ASPG H-InvDB: ASPG

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ASPG Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ASPG gene:
    Search GeneIP for patents involving ASPG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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