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Aliases for ASPG Gene

Aliases for ASPG Gene

  • Asparaginase 2 3
  • 60-KDa-Lysophospholipase 2 3
  • C14orf76 3 4
  • Asparaginase Homolog (S. Cerevisiae) 2
  • Chromosome 14 Open Reading Frame 76 2
  • 60 KDa Lysophospholipase 3
  • Wild-Type L-Asparaginase 3
  • Asparaginase Homolog 3
  • EC 4
  • ASPGX1 6
  • AUTSX1 6
  • GPA/WT 3
  • NLGN3 6

External Ids for ASPG Gene

Previous HGNC Symbols for ASPG Gene

  • C14orf76

Previous GeneCards Identifiers for ASPG Gene

  • GC14P103622
  • GC14P104552
  • GC14P084732

Summaries for ASPG Gene

GeneCards Summary for ASPG Gene

ASPG (Asparaginase) is a Protein Coding gene. Among its related pathways are Cell adhesion molecules (CAMs) and asparagine degradation I. GO annotations related to this gene include lysophospholipase activity and asparaginase activity.

UniProtKB/Swiss-Prot for ASPG Gene

  • Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASPG Gene

Genomics for ASPG Gene

Regulatory Elements for ASPG Gene

Genomic Location for ASPG Gene

104,085,679 bp from pter
104,115,581 bp from pter
29,903 bases
Plus strand

Genomic View for ASPG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ASPG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASPG Gene

Proteins for ASPG Gene

  • Protein details for ASPG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60 kDa lysophospholipase
    Protein Accession:
    Secondary Accessions:
    • B9EGQ2
    • Q8IV80

    Protein attributes for ASPG Gene

    573 amino acids
    Molecular mass:
    60883 Da
    Quaternary structure:
    • Monomer.
    • Sequence=CAD62331.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Alternative splice isoforms for ASPG Gene


neXtProt entry for ASPG Gene

Proteomics data for ASPG Gene at MOPED

Post-translational modifications for ASPG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ASPG Gene

No data available for DME Specific Peptides for ASPG Gene

Domains for ASPG Gene

Gene Families for ASPG Gene

Suggested Antigen Peptide Sequences for ASPG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 asparaginase/glutaminase domain.
  • In the N-terminal section; belongs to the asparaginase 1 family.
  • Contains 5 ANK repeats.
  • Contains 1 asparaginase/glutaminase domain.
  • In the N-terminal section; belongs to the asparaginase 1 family.
  • Contains 5 ANK repeats.
genes like me logo Genes that share domains with ASPG: view

Function for ASPG Gene

Molecular function for ASPG Gene

UniProtKB/Swiss-Prot CatalyticActivity:
2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate
UniProtKB/Swiss-Prot CatalyticActivity:
L-asparagine + H(2)O = L-aspartate + NH(3)
UniProtKB/Swiss-Prot CatalyticActivity:
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H(2)O = 1-alkyl-sn-glycero-3-phosphocholine + acetate
UniProtKB/Swiss-Prot Function:
Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities

Enzyme Numbers (IUBMB) for ASPG Gene

Gene Ontology (GO) - Molecular Function for ASPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity IEA --
GO:0004067 asparaginase activity IEA --
GO:0004622 lysophospholipase activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ASPG: view

Animal Model Products

CRISPR Products

miRNA for ASPG Gene

miRTarBase miRNAs that target ASPG

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ASPG Gene

Localization for ASPG Gene

Subcellular locations from

Jensen Localization Image for ASPG Gene COMPARTMENTS Subcellular localization image for ASPG gene
Compartment Confidence
cytosol 3
mitochondrion 3
vacuole 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ASPG Gene

Pathways for ASPG Gene

genes like me logo Genes that share pathways with ASPG: view

Pathways by source for ASPG Gene

1 BioSystems pathway for ASPG Gene
1 KEGG pathway for ASPG Gene

Gene Ontology (GO) - Biological Process for ASPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006520 cellular amino acid metabolic process --
GO:0006528 asparagine metabolic process IEA --
GO:0006644 phospholipid metabolic process IEA --
GO:0016042 lipid catabolic process IEA --
genes like me logo Genes that share ontologies with ASPG: view

Compounds for ASPG Gene

(46) HMDB Compounds for ASPG Gene

Compound Synonyms Cas Number PubMed IDs
Arachidic acid
  • Arachate
Arachidonic acid
  • 5,8,11,14-Eicosatetraenoic acid
  • 2-[[(2,3-dihydroxypropoxy)hydroxyphosphinyl]oxy]-N,N,N-trimethyl-Ethanaminium inner salt
Heptadecanoic acid
  • Heptadecanoate
Heptadecanoyl CoA
  • Heptadecanoyl coenzyme A
genes like me logo Genes that share compounds with ASPG: view

Transcripts for ASPG Gene

Unigene Clusters for ASPG Gene

Asparaginase homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ASPG

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ASPG Gene

No ASD Table

Relevant External Links for ASPG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ASPG Gene

mRNA expression in normal human tissues for ASPG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ASPG Gene

This gene is overexpressed in Liver (20.2) and Heart - Atrial Appendage (14.1).

Protein differential expression in normal tissues for ASPG Gene

This gene is overexpressed in Liver (28.3), Kidney (16.1), Gallbladder (11.1), and Esophagus (9.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ASPG Gene

SOURCE GeneReport for Unigene cluster for ASPG Gene Hs.146239

genes like me logo Genes that share expressions with ASPG: view

Expression partners for ASPG Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ASPG Gene

Orthologs for ASPG Gene

This gene was present in the common ancestor of animals.

Orthologs for ASPG Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ASPG 35
  • 85.58 (n)
  • 81.44 (a)
  • 80 (a)
(Canis familiaris)
Mammalia ASPG 35
  • 83.43 (n)
  • 81.35 (a)
  • 81 (a)
(Mus musculus)
Mammalia Aspg 35
  • 80.38 (n)
  • 79.96 (a)
Aspg 16
Aspg 36
  • 80 (a)
(Pan troglodytes)
Mammalia ASPG 35
  • 98.37 (n)
  • 98.08 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Aspg 35
  • 79.79 (n)
  • 79.26 (a)
(Monodelphis domestica)
Mammalia ASPG 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia ASPG 36
  • 65 (a)
(Gallus gallus)
Aves ASPG 36
  • 49 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 50 (a)
-- 36
  • 39 (a)
(Danio rerio)
Actinopterygii aspg 36
  • 43 (a)
ASPG (2 of 3) 36
  • 15 (a)
ASPG (3 of 3) 36
  • 23 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6428 36
  • 36 (a)
CG8526 36
  • 33 (a)
(Caenorhabditis elegans)
Secernentea C27A7.5 36
  • 30 (a)
Species with no ortholog for ASPG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ASPG Gene

Gene Tree for ASPG (if available)
Gene Tree for ASPG (if available)

Paralogs for ASPG Gene

(4) SIMAP similar genes for ASPG Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ASPG: view

No data available for Paralogs for ASPG Gene

Variants for ASPG Gene

Sequence variations from dbSNP and Humsavar for ASPG Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs737393 -- 104,099,782(-) TTTGG(A/G)GCTGC intron-variant
rs737394 -- 104,099,585(-) CGGAG(A/C)GACGG intron-variant
rs747247 -- 104,099,652(-) CTGGA(A/G)CAGGC intron-variant
rs752622 -- 104,092,992(-) TTGCC(A/G)AAGCA intron-variant, utr-variant-5-prime, nc-transcript-variant
rs754415 -- 104,091,982(+) CAGAG(C/T)TGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ASPG Gene

Variant ID Type Subtype PubMed ID
nsv902319 CNV Gain 21882294
nsv526680 CNV Gain 19592680
dgv1998n71 CNV Loss 21882294
dgv1999n71 CNV Loss 21882294
nsv470674 CNV Loss 18288195
dgv2000n71 CNV Loss 21882294
dgv2001n71 CNV Loss 21882294
nsv902336 CNV Loss 21882294
nsv902339 CNV Gain 21882294
nsv519605 CNV Loss 19592680
esv2749179 CNV Deletion 23290073
esv2749180 CNV Deletion 23290073
nsv902350 CNV Loss 21882294
esv2749181 CNV Deletion 23290073
dgv303e201 CNV Deletion 23290073
esv2749183 CNV Deletion 23290073
dgv304e201 CNV Deletion 23290073
esv2749189 CNV Deletion 23290073

Relevant External Links for ASPG Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASPG Gene

Disorders for ASPG Gene

(2) OMIM Diseases for ASPG Gene (300336)

Relevant External Links for ASPG

Genetic Association Database (GAD)

No disorders were found for ASPG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ASPG Gene

Publications for ASPG Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. 60kDa lysophospholipase, a new Sgk1 molecular partner involved in the regulation of ENaC. (PMID: 21063096) Menniti M. … Perrotti N. (Cell. Physiol. Biochem. 2010) 3
  3. Structures of apo and product-bound human L-asparaginase: insights into the mechanism of autoproteolysis and substrate hydrolysis. (PMID: 22861376) Nomme J. … Lavie A. (Biochemistry 2012) 3
  4. Human 60-kDa lysophospholipase contains an N-terminal L-asparaginase domain that is allosterically regulated by L-asparagine. (PMID: 24657844) Karamitros C.S. … Konrad M. (J. Biol. Chem. 2014) 3
  5. Elucidation of the specific function of the conserved threonine triad responsible for human L-asparaginase autocleavage and substrate hydrolysis. (PMID: 24768817) Nomme J. … Lavie A. (J. Mol. Biol. 2014) 3

Products for ASPG Gene

Sources for ASPG Gene

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