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ASPDH Gene(Protein Coding)

Aspartate Dehydrogenase Domain Containing

GCID:
GC19M050511
GIFtS:
43
Genes Participants
UDN Logo

Aliases for ASPDH Gene

Aliases for ASPDH Gene

  • Aspartate Dehydrogenase Domain Containing 2 3 5
  • Aspartate Dehydrogenase Domain-Containing Protein 4
  • EC 1.4.1.21 4

External Ids for ASPDH Gene

Previous GeneCards Identifiers for ASPDH Gene

  • GC19M055710
  • GC19M051014
  • GC19M047351

Summaries for ASPDH Gene

GeneCards Summary for ASPDH Gene

ASPDH (Aspartate Dehydrogenase Domain Containing) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity and aspartate dehydrogenase activity.

UniProtKB/Swiss-Prot for ASPDH Gene

  • Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASPDH Gene

Genomics for ASPDH Gene

Products:

  1. Regulatory Element

Regulatory Elements for ASPDH Gene

Enhancers for ASPDH Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G050555 1.8 FANTOM5 Ensembl ENCODE dbSUPER 16.5 -41.9 -41852 2.0 HDGF ATF1 SIN3A ZNF2 ZNF48 ZNF121 GLIS2 ZNF143 ZNF207 SP3 ASPDH JOSD2 LINC01869 SNORD88C C19orf48 KLK4 C19orf81 SYT3 ACPT LRRC4B
GH19G050496 1.9 FANTOM5 Ensembl ENCODE dbSUPER 8 +15.3 15343 6.1 HDGF ATF1 PKNOX1 CREB3L1 GLI4 ZNF48 TCF12 GLIS2 GATA2 KLF13 PRR12 CTU1 JOSD2 ASPDH MYH14 MYBPC2 LOC100506114
GH19G050695 0.8 FANTOM5 19 -180.7 -180684 0.4 MXI1 ZNF777 ZSCAN4 ZNF48 POLR2A ELK1 ZNF652 CREM SP3 NRF1 ASPDH SYT3 KCNC3 LRRC4B SPACA6P-AS FUZ SHANK1 KLK6 PIR41386
GH19G050488 1.7 FANTOM5 Ensembl ENCODE dbSUPER 8.9 +24.2 24178 4.6 HDAC1 PKNOX1 CBX3 KLF17 NFXL1 ZNF48 YY1 EGR1 ZNF366 HSF1 SNORD35A RPS11 SNORD35B POLD1 PTOV1-AS2 PRR12 PNKP NUP62 SIGLEC17P ASPDH
GH19G050537 1.2 ENCODE dbSUPER 12.3 -23.2 -23189 0.1 SIN3A ZNF2 ZNF48 ZNF143 KLF13 REST ZNF592 ZNF579 MEF2D SMARCA4 ASPDH JOSD2 LRRC4B GPR32 SNORD88A SNORD88B SNORD88C NAPSA NR1H2 C19orf48
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ASPDH on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ASPDH gene promoter:

Genomic Location for ASPDH Gene

Chromosome:
19
Start:
50,511,600 bp from pter
End:
50,514,690 bp from pter
Size:
3,091 bases
Orientation:
Minus strand

Genomic View for ASPDH Gene

Genes around ASPDH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASPDH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASPDH Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ASPDH Gene

Proteins for ASPDH Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ASPDH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6ND91-ASPD_HUMAN
    Recommended name:
    Putative L-aspartate dehydrogenase
    Protein Accession:
    A6ND91
    Secondary Accessions:
    • Q6NZ37

    Protein attributes for ASPDH Gene

    Size:
    283 amino acids
    Molecular mass:
    29946 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.

    Alternative splice isoforms for ASPDH Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASPDH Gene

Protein Expression for ASPDH Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ASPDH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ASPDH Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ASPDH Gene

Domains & Families for ASPDH Gene

Protein Domains for ASPDH Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ASPDH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6ND91

UniProtKB/Swiss-Prot:

ASPD_HUMAN :
  • Belongs to the L-aspartate dehydrogenase family.
Family:
  • Belongs to the L-aspartate dehydrogenase family.
genes like me logo Genes that share domains with ASPDH: view

No data available for Gene Families for ASPDH Gene

Function for ASPDH Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for ASPDH Gene

UniProtKB/Swiss-Prot CatalyticActivity:
L-aspartate + H(2)O + NAD(P)(+) = oxaloacetate + NH(3) + NAD(P)H.
UniProtKB/Swiss-Prot Function:
Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.

Enzyme Numbers (IUBMB) for ASPDH Gene

Gene Ontology (GO) - Molecular Function for ASPDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
GO:0033735 aspartate dehydrogenase activity IEA --
GO:0050661 NADP binding IEA --
genes like me logo Genes that share ontologies with ASPDH: view

Phenotypes for ASPDH Gene

GenomeRNAi human phenotypes for ASPDH:
genes like me logo Genes that share phenotypes with ASPDH: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ASPDH Gene

Localization for ASPDH Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ASPDH gene
Compartment Confidence
mitochondrion 3
nucleus 2
plasma membrane 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ASPDH Gene

Pathways & Interactions for ASPDH Gene

SuperPathways for ASPDH Gene

PathCards logo More details on SuperPathways for ASPDH
No Data Available

UniProtKB/Swiss-Prot A6ND91-ASPD_HUMAN

  • Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (dehydrogenase route): step 1/1.

Gene Ontology (GO) - Biological Process for ASPDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006742 NADP catabolic process IEA --
GO:0009435 NAD biosynthetic process IEA --
GO:0019363 pyridine nucleotide biosynthetic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with ASPDH: view

No data available for Pathways by source and SIGNOR curated interactions for ASPDH Gene

Drugs & Compounds for ASPDH Gene

Products:

  1. Drug

(3) Drugs for ASPDH Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
L-Aspartic acid Approved Nutra 0
NAD Pharma Full agonist, Agonist 0

(4) Additional Compounds for ASPDH Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ammonia
  • Ammonia anhydrous
  • Ammonia inhalant
  • Ammonia solution strong [usan]
  • Ammonia water
  • Ammoniak
 7664-41-7
Iminoaspartic acid
  • alpha-Iminosuccinate
  • Imino-Butanedioate
  • Imino-Butanedioic acid
  • Iminoaspartate
  • Iminoaspartic acid
 79067-61-1
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
 53-59-8
Oxalacetic acid
  • 2-Ketosuccinate
  • 2-Ketosuccinic acid
  • 2-Oxobutanedioate
  • 2-Oxobutanedioic acid
  • 2-Oxosuccinate
 328-42-7
genes like me logo Genes that share compounds with ASPDH: view

Transcripts for ASPDH Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for ASPDH Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ASPDH Gene

Aspartate dehydrogenase domain containing:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ASPDH Gene

No ASD Table

Relevant External Links for ASPDH Gene

GeneLoc Exon Structure for
ASPDH
ECgene alternative splicing isoforms for
ASPDH

Expression for ASPDH Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ASPDH Gene

mRNA expression in normal human tissues for ASPDH Gene
mRNA expression by BioGPS for ASPDH GenemRNA expression by GTEx for ASPDH Gene

mRNA differential expression in normal tissues according to GTEx for ASPDH Gene

This gene is overexpressed in Liver (x12.3).

Protein differential expression in normal tissues from HIPED for ASPDH Gene

This gene is overexpressed in Gallbladder (12.8), Nasal epithelium (9.7), Monocytes (8.4), Neutrophil (8.1), Esophagus (7.4), and Liver, secretome (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ASPDH Gene



NURSA nuclear receptor signaling pathways regulating expression of ASPDH Gene:

ASPDH

SOURCE GeneReport for Unigene cluster for ASPDH Gene:

Hs.436338

Evidence on tissue expression from TISSUES for ASPDH Gene

  • Liver(4.3)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ASPDH: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ASPDH Gene

Orthologs for ASPDH Gene

This gene was present in the common ancestor of animals.

Orthologs for ASPDH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ASPDH 34 35
  • 99.53 (n)
dog
(Canis familiaris)
 Mammalia ASPDH 34 35
  • 87.43 (n)
mouse
(Mus musculus)
 Mammalia Aspdh 34 16 35
  • 86.09 (n)
cow
(Bos Taurus)
 Mammalia ASPDH 35
  • 85 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Aspdh 34
  • 84.69 (n)
lizard
(Anolis carolinensis)
 Reptilia ASPDH 35
  • 53 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii aspdh 34 35
  • 53.33 (n)
worm
(Caenorhabditis elegans)
 Secernentea CELE_F17C8.9 34
  • 49.04 (n)
F17C8.9 35
  • 45 (a)
 OneToOne
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 47 (a)
 OneToOne
Species where no ortholog for ASPDH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ASPDH Gene

ENSEMBL:
Gene Tree for ASPDH (if available)
TreeFam:
Gene Tree for ASPDH (if available)

Paralogs for ASPDH Gene

No data available for Paralogs for ASPDH Gene

Variants for ASPDH Gene

Sequence variations from dbSNP and Humsavar for ASPDH Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000767299 -- 50,512,896(+) GCAGG(A/G)CTCTG intron-variant, upstream-variant-2KB
rs1001688377 -- 50,514,533(+) CAGTG(A/T)GACGT upstream-variant-2KB, utr-variant-5-prime
rs1002035677 -- 50,516,459(+) TGGAC(A/G)CAGAC downstream-variant-500B, upstream-variant-2KB
rs1003097628 -- 50,515,521(+) ACCGG(C/T)CAGAA upstream-variant-2KB
rs1003570295 -- 50,516,573(+) GCTGG(C/T)GAGGC downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ASPDH Gene

Variant ID Type Subtype PubMed ID
nsv1133010 OTHER inversion 24896259
nsv1140251 OTHER inversion 24896259
nsv1152956 OTHER inversion 26484159
nsv509750 CNV insertion 20534489
nsv953604 CNV deletion 24416366

Variation tolerance for ASPDH Gene

Residual Variation Intolerance Score: 61.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.77; 58.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ASPDH Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ASPDH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASPDH Gene

Disorders for ASPDH Gene

Relevant External Links for ASPDH

Genetic Association Database (GAD)
ASPDH
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ASPDH

No disorders were found for ASPDH Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASPDH Gene

Publications for ASPDH Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 64
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 64

Products for ASPDH Gene

Sources for ASPDH Gene

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