ASPDH Gene
protein-coding GIFtS: 36
GCID: GC19M051014
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aspartate dehydrogenase domain containing
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Aliases
for ASPDH gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Aspartate Dehydrogenase Domain Containing1 2 | | Aspartate Dehydrogenase Domain-Containing Protein2 3 | | Putative L-Aspartate Dehydrogenase2 | | EC 1.4.1.213 |
Export aliases for ASPDH gene to outside databasesPrevious GC identifers: GC19M055710 GC19M047351 |
Summaries
for ASPDH gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ASPD_HUMAN, A6ND91Function: Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (Bysimilarity)
|
Genomic Views
for ASPDH gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ASPDH gene promoter:
PPAR-alpha Pax-5 ZIC2/Zic2 ATF Egr-4
Other transcription factors
Search SABiosciences Chromatin IP Primers for ASPDH
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASPDH |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.33 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.33ASPDH Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M051014: view genomic region
(about GC identifiers)
Start:
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51,014,857 bp from pter |
End:
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51,017,947 bp from pter |
Size:
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3,091 bases |
Orientation:
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minus strand |
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Proteins
for ASPDH gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ASPD_HUMAN, A6ND91 (See
protein sequence)Recommended Name: Putative L-aspartate dehydrogenase Size: 283 amino acids; 29946 Da
Miscellaneous: The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia(By similarity)
Secondary accessions: Q6NZ37Alternative splicing: 2 isoforms: A6ND91-1 A6ND91-2 Explore the universe of human proteins at neXtProt for ASPDH: NX_A6ND91
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A6ND91
ASPDH Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001019827.2 NP_001108070.1
ENSEMBL proteins: ENSP00000366114 ENSP00000373860
Human Recombinant Protein Products:
ASPDH Antibody Products:
Assay Products for ASPDH: |
Protein
Domains /
Families
for ASPDH gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ASPDH for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A6ND91ProtoNet protein and cluster: A6ND91 UniProtKB/Swiss-Prot: ASPD_HUMAN, A6ND91Similarity: Belongs to the L-aspartate dehydrogenase family |
Function
for ASPDH gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ASPD_HUMAN, A6ND91Function: Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (Bysimilarity)Catalytic activity: L-aspartate + H(2)O + NAD(P)(+) = oxaloacetate + NH(3) + NAD(P)HEnzyme Number (IUBMB): EC 1.4.1.211
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASPDH (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASPDH (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ASPDH (NM_001114598) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ASPDH | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASPDH |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASPDH |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0033735 | aspartate dehydrogenase activity |
IEA | -- | | GO:0050661 | NADP binding |
IEA | -- |
ASPDH for ontologies About GeneDecksing
|
Pathways & Interactions
for ASPDH gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
UniProtKB/Swiss-Prot: ASPD_HUMAN, A6ND91Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (dehydrogenase route): step 1/1Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ASPDH
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006742 | NADP catabolic process |
IEA | -- | | GO:0009435 | NAD biosynthetic process |
IEA | -- |
ASPDH for ontologies About GeneDecksing
|
Drugs & Compounds
for ASPDH gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ASPDH
3 HMDB Compounds for ASPDH About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| Iminoaspartic acid | Iminoaspartate (see all 6) | 79067-61-1 | -- | | NAD | 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28) | 53-84-9 | -- | | NADP | Adenine-nicotinamide dinucleotide phosphate (see all 18) | 53-59-8 | -- |
Search CenterWatch for drugs/clinical trials and news about ASPDH / ASPD
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Transcripts
for ASPDH gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ASPDH gene (2 alternative transcripts): NM_001024656.2 NM_001114598.1 Unigene Cluster for ASPDH: Aspartate dehydrogenase domain containing Hs.436338 [show with all ESTs]Unigene Representative Sequence: NM_0011145982 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000376916(uc002psr.4) ENST00000389208(uc010enz.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASPDH (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASPDH (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ASPDH (NM_001114598) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ASPDH | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASPDH |
Additional cDNA sequence: BC066359.1 4 DOTS entries: DT.86841248 DT.75101155 DT.97765924 DT.95096965
GeneLoc Exon Structure
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Expression
for ASPDH gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ASPDH expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCGGCGGCTG
About this image
See ASPDH Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ASPDH
SOURCE GeneReport for Unigene cluster: Hs.436338
SABiosciences Custom PCR Arrays for ASPDH
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ASPDH
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ASPDH | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ASPDH | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASPDH | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASPDH |
Orthologs
for ASPDH gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ASPDH gene from 4/12 species (see all 12) About this table
ENSEMBL Gene Tree for ASPDH (if available)
TreeFam Gene Tree for ASPDH (if available) |
Paralogs
for ASPDH gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for ASPDH gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ASPDH (51014857 - 51017947 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ASPDH: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ASPDH |
|
Disorders
/ Diseases
for ASPDH gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ASPDH gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ASPDH gene integrated from 9 sources:
(articles sorted by number of sources associating them with ASPDH) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
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External Searches for ASPDH gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing ASPDH gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ASPDH gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ASPDH gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ASPDH | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for ASPDH gene:
Search GeneIP for patents involving ASPDH
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ASPDH gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ASPDH | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ASPDH | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ASPDH | | | OriGene Protein Over-expression Lysate for ASPDH | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ASPDH | | OriGene 3'-UTR Clone for ASPDH | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASPDH | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASPDH | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ASPDH | | OriGene Custom Protein Services for ASPDH | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ASPDH | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ASPDH | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASPDH | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ASPDH | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASPDH | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ASPDH |
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 |  |  |  | |
| | | | Search Tocris compounds for ASPDH |
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 | | | ASPDH Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASPDH |
|  |  |  | | | | Search ThermoFisher Antibodies for ASPDH |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASPDH |
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