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ASPDH Gene

protein-coding   GIFtS: 40
GCID: GC19M051014

Aspartate Dehydrogenase Domain Containing

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Aspartate Dehydrogenase Domain Containing1 2
Aspartate Dehydrogenase Domain-Containing Protein2 3
Putative L-Aspartate Dehydrogenase2
EC 1.4.1.213

External Ids:    HGNC: 338561   Entrez Gene: 5542352   Ensembl: ENSG000002046537   UniProtKB: A6ND913   
ORGUL members:         

Export aliases for ASPDH gene to outside databases

Previous GC identifers: GC19M055710 GC19M047351


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ASPDH Gene:
ASPDH (aspartate dehydrogenase domain containing) is a protein-coding gene. GO annotations related to this gene include NADP binding and aspartate dehydrogenase activity.

UniProtKB/Swiss-Prot: ASPD_HUMAN, A6ND91
Function: Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ASPDH gene promoter:
         PPAR-alpha   Pax-5   ZIC2/Zic2   ATF   Egr-4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ASPDH

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ASPDH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.33   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.33

ASPDH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASPDH gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M051014:  view genomic region     (about GC identifiers)

Start:
51,014,857 bp from pter      End:
51,017,947 bp from pter
Size:
3,091 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ASPD_HUMAN, A6ND91 (See protein sequence)
Recommended Name: Putative L-aspartate dehydrogenase  
Size: 283 amino acids; 29946 Da
Miscellaneous: The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and
ammonia (By similarity)
Secondary accessions: Q6NZ37
Alternative splicing: 2 isoforms:  A6ND91-1   A6ND91-2   

Explore the universe of human proteins at neXtProt for ASPDH: NX_A6ND91

Explore proteomics data for ASPDH at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ASPDH Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001019827.2  NP_001108070.1  

    ENSEMBL proteins: 
     ENSP00000366114   ENSP00000373860   ENSP00000470360   ENSP00000469754  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR005106 Asp/hSer_DH_NAD-bd
     IPR011182 Asp_DH_NAD_syn
     IPR016040 NAD(P)-bd_dom
     IPR002811 Asp_DH

    Graphical View of Domain Structure for InterPro Entry A6ND91

    ProtoNet protein and cluster: A6ND91

    UniProtKB/Swiss-Prot: ASPD_HUMAN, A6ND91
    Similarity: Belongs to the L-aspartate dehydrogenase family


    Find genes that share domains with ASPDH           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ASPD_HUMAN, A6ND91
    Function: Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By
    similarity)
    Catalytic activity: L-aspartate + H(2)O + NAD(P)(+) = oxaloacetate + NH(3) + NAD(P)H

         Enzyme Number (IUBMB): EC 1.4.1.211

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016491oxidoreductase activity ----
    GO:0033735aspartate dehydrogenase activity IEA--
    GO:0050661NADP binding IEA--
         
    Find genes that share ontologies with ASPDH           About GenesLikeMe


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion3
    nucleus2
    cytosol1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: ASPD_HUMAN, A6ND91
    Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (dehydrogenase route): step
    1/1

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    Interactions:

        Search GeneGlobe Interaction Network for ASPDH

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006742NADP catabolic process IEA--
    GO:0009435NAD biosynthetic process IEA--
    GO:0019363pyridine nucleotide biosynthetic process ----
    GO:0055114oxidation-reduction process ----

    Find genes that share ontologies with ASPDH           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Tocris compounds for ASPDH (ASPD)

    3 HMDB Compounds for ASPDH    About this table
    CompoundSynonyms CAS #PubMed Ids
    Iminoaspartic acidIminoaspartate (see all 6)79067-61-1--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ASPDH gene (2 alternative transcripts): 
    NM_001024656.2  NM_001114598.1  

    Unigene Cluster for ASPDH:

    Aspartate dehydrogenase domain containing
    Hs.436338  [show with all ESTs]
    Unigene Representative Sequence: NM_001114598
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376916(uc002psr.4) ENST00000597232 ENST00000389208(uc010enz.3)
    ENST00000601207 ENST00000601287 ENST00000597030 ENST00000593569 ENST00000598657

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    Additional mRNA sequence: BC066359.1 

    4 DOTS entries:

    DT.86841248  DT.75101155  DT.97765924  DT.95096965 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ASPDH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGGCGGCTG
    ASPDH Expression
    About this image

    ASPDH Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ASPDH Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.436338
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ASPDH gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aspdh1 , 5 aspartate dehydrogenase domain containing1, 5 86.09(n)1
    89.21(a)1
      7 (28.83 cM)5
    683521  NM_026690.11  NP_080966.11 
     444653915 
    lizard
    (Anolis carolinensis)
    Reptilia ASPDH6
    aspartate dehydrogenase domain containing
    53(a)
    1 ↔ 1
    6(78872251-78884510)
    zebrafish
    (Danio rerio)
    Actinopterygii aspdh1 aspartate dehydrogenase domain containing 53.33(n)
    49.82(a)
      447919  NM_001004657.1  NP_001004657.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_F17C8.91 CELE_F17C8.9 49.04(n)
    47.89(a)
      13189316  NM_001267991.1  NP_001254920.1 


    ENSEMBL Gene Tree for ASPDH (if available)
    TreeFam Gene Tree for ASPDH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ASPDH (see all 84)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1407230661,2
    --51016833(+) ACAGTA/GGGGTG 2 -- int10--------
    rs1446588721,2
    C--51016870(+) AGAGAC/TGGAGA 2 -- int10--------
    rs1478763131,2
    --51017051(+) ACCACA/GCCCAC 3 G int1 syn10--------
    rs771772541,2
    C--51017063(+) CTCCAC/TGGGCC 3 P int1 syn10--------
    rs72482721,2
    C,F--51017064(+) TCCACG/CGGCCC 3 /P /R int1 mis12Minor allele frequency- C:0.10WA EA 238
    rs1818145231,2
    --51017153(+) CAGCCA/GCTGCT 2 -- int1 us2k10--------
    rs17268241,2
    C,F,A,H--51017325(+) TGGGAG/ACCCTG 2 -- int1 us2k114Minor allele frequency- A:0.21NA WA CSA EA 380
    rs350179731,2
    C,F--51017377(+) CTGATG/ATGGAA 2 -- int1 us2k16Minor allele frequency- A:0.20NA WA EA 364
    rs1863783761,2
    C--51017711(+) CCCTCC/TGCTCT 2 -- int1 us2k10--------
    rs16730231,2
    C,F,H--51017726(-) AACTGA/GAGGAT 2 -- int1 us2k16Minor allele frequency- G:0.01NS NA 606

    HapMap Linkage Disequilibrium report for ASPDH (51014857 - 51017947 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ASPDH:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509750CNV Insertion20534489
    nsv912284CNV Loss21882294
    nsv912282CNV Loss21882294
    nsv912283CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with ASPDH           About GenesLikeMe

    Genetic Association Database (GAD): ASPDH

    Export disorders for ASPDH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ASPDH gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ASPDH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    2. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)
    6. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 554235 HGNC: 33856 Ensembl:ENSG00000204653 euGenes: HUgn554235 ECgene: ASPDH
    H-InvDB: ASPDH

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ASPDH Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ASPDH gene:
    Search GeneIP for patents involving ASPDH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     Search for Antibodies & Assays

     Search Tocris compounds for ASPDH (ASPD)
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
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     See all of Abcam's Antibodies, Kits and Proteins for ASPDH
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     Browse compounds at ApexBio
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     antibodies-online antibodies for ASPDH (4 products)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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