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Aliases for ASPDH Gene

Aliases for ASPDH Gene

  • Aspartate Dehydrogenase Domain Containing 2 3 5
  • Aspartate Dehydrogenase Domain-Containing Protein 4
  • EC 1.4.1.21 4

External Ids for ASPDH Gene

Previous GeneCards Identifiers for ASPDH Gene

  • GC19M055710
  • GC19M051014
  • GC19M047351

Summaries for ASPDH Gene

GeneCards Summary for ASPDH Gene

ASPDH (Aspartate Dehydrogenase Domain Containing) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity and aspartate dehydrogenase activity.

UniProtKB/Swiss-Prot for ASPDH Gene

  • Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.

Additional gene information for ASPDH Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASPDH Gene

Genomics for ASPDH Gene

Regulatory Elements for ASPDH Gene

Enhancers for ASPDH Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H050555 1.8 FANTOM5 Ensembl ENCODE dbSUPER 16.4 -41.9 -41852 1 HDGF ATF1 SIN3A ZNF2 ZNF121 GLIS2 ZNF143 ZNF207 ATF7 SP3 ASPDH JOSD2 PTOV1 LINC01869 C19orf48 SNORD88C KLK4 C19orf81 SYT3 ACP4
GH19H050695 0.8 FANTOM5 19 -180.7 -180684 0 MXI1 SP3 ZNF777 NRF1 ZSCAN4 MIER2 ZNF398 REST ZNF560 GABPA ASPDH SYT3 KCNC3 LRRC4B SPACA6P-AS FUZ SHANK1 KLK6 PIR41386
GH19H050488 1.7 FANTOM5 Ensembl ENCODE dbSUPER 8.8 +24.2 24178 4 PKNOX1 KLF17 NFXL1 ZNF366 HSF1 SCRT2 EGR2 ZNF202 SP3 ZNF114 SNORD35A NUP62 POLD1 PTOV1-AS2 PRR12 SNORD35B IRF3 RPS11 ENSG00000268047 PNKP
GH19H050537 1.2 ENCODE dbSUPER 12.2 -23.2 -23189 0 SIN3A ZNF2 ZNF143 ATF7 REST ZNF592 MEF2D GLIS1 NR2C1 KDM1A ASPDH JOSD2 LRRC4B GPR32 SNORD88A SNORD88B SNORD88C NAPSA NR1H2 C19orf48
GH19H050510 1.4 ENCODE dbSUPER 10.4 +3.4 3397 2 HDGF PKNOX1 ARNT SIN3A ZNF2 YY1 CBX5 ZNF207 ZNF143 DEK NR1H2 RRAS PRR12 CTU1 PRMT1 NAPSB ENSG00000268047 ASPDH CLEC11A NUP62
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ASPDH on UCSC Golden Path with GeneCards custom track

Genomic Location for ASPDH Gene

Chromosome:
19
Start:
50,511,600 bp from pter
End:
50,514,690 bp from pter
Size:
3,091 bases
Orientation:
Minus strand

Genomic View for ASPDH Gene

Genes around ASPDH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASPDH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASPDH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASPDH Gene

Proteins for ASPDH Gene

  • Protein details for ASPDH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6ND91-ASPD_HUMAN
    Recommended name:
    Putative L-aspartate dehydrogenase
    Protein Accession:
    A6ND91
    Secondary Accessions:
    • Q6NZ37

    Protein attributes for ASPDH Gene

    Size:
    283 amino acids
    Molecular mass:
    29946 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.

    Alternative splice isoforms for ASPDH Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASPDH Gene

Post-translational modifications for ASPDH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ASPDH Gene

No data available for DME Specific Peptides for ASPDH Gene

Domains & Families for ASPDH Gene

Gene Families for ASPDH Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for ASPDH Gene

Suggested Antigen Peptide Sequences for ASPDH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6ND91

UniProtKB/Swiss-Prot:

ASPD_HUMAN :
  • Belongs to the L-aspartate dehydrogenase family.
Family:
  • Belongs to the L-aspartate dehydrogenase family.
genes like me logo Genes that share domains with ASPDH: view

Function for ASPDH Gene

Molecular function for ASPDH Gene

UniProtKB/Swiss-Prot CatalyticActivity:
L-aspartate + H(2)O + NAD(P)(+) = oxaloacetate + NH(3) + NAD(P)H.
UniProtKB/Swiss-Prot Function:
Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.

Enzyme Numbers (IUBMB) for ASPDH Gene

Phenotypes From GWAS Catalog for ASPDH Gene

Gene Ontology (GO) - Molecular Function for ASPDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
GO:0033735 aspartate dehydrogenase activity IEA --
GO:0050661 NADP binding IEA --
genes like me logo Genes that share ontologies with ASPDH: view

Phenotypes for ASPDH Gene

GenomeRNAi human phenotypes for ASPDH:
genes like me logo Genes that share phenotypes with ASPDH: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ASPDH
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ASPDH Gene

Localization for ASPDH Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ASPDH gene
Compartment Confidence
mitochondrion 3
nucleus 2
plasma membrane 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ASPDH Gene

Pathways & Interactions for ASPDH Gene

SuperPathways for ASPDH Gene

No Data Available

UniProtKB/Swiss-Prot A6ND91-ASPD_HUMAN

  • Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (dehydrogenase route): step 1/1.

Gene Ontology (GO) - Biological Process for ASPDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006742 NADP catabolic process IEA --
GO:0009435 NAD biosynthetic process IEA --
GO:0019363 pyridine nucleotide biosynthetic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with ASPDH: view

No data available for Pathways by source and SIGNOR curated interactions for ASPDH Gene

Drugs & Compounds for ASPDH Gene

(4) Drugs for ASPDH Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ammonia Approved Pharma 0
Water Approved Pharma 0
L-Aspartic acid Approved Nutra 0
NAD Pharma Full agonist, Agonist 0

(3) Additional Compounds for ASPDH Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Iminoaspartic acid
  • alpha-Iminosuccinate
  • Imino-Butanedioate
  • Imino-Butanedioic acid
  • Iminoaspartate
  • Iminoaspartic acid
79067-61-1
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
Oxalacetic acid
  • 2-Ketosuccinate
  • 2-Ketosuccinic acid
  • 2-Oxobutanedioate
  • 2-Oxobutanedioic acid
  • 2-Oxosuccinate
328-42-7
genes like me logo Genes that share compounds with ASPDH: view

Transcripts for ASPDH Gene

mRNA/cDNA for ASPDH Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ASPDH Gene

Aspartate dehydrogenase domain containing:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ASPDH
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ASPDH Gene

No ASD Table

Relevant External Links for ASPDH Gene

GeneLoc Exon Structure for
ASPDH
ECgene alternative splicing isoforms for
ASPDH

Expression for ASPDH Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ASPDH Gene

mRNA differential expression in normal tissues according to GTEx for ASPDH Gene

This gene is overexpressed in Liver (x12.3).

Protein differential expression in normal tissues from HIPED for ASPDH Gene

This gene is overexpressed in Gallbladder (12.8), Nasal epithelium (9.7), Monocytes (8.4), Neutrophil (8.1), Esophagus (7.4), and Liver, secretome (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ASPDH Gene



NURSA nuclear receptor signaling pathways regulating expression of ASPDH Gene:

ASPDH

SOURCE GeneReport for Unigene cluster for ASPDH Gene:

Hs.436338

Evidence on tissue expression from TISSUES for ASPDH Gene

  • Liver(4.3)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ASPDH: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ASPDH Gene

Orthologs for ASPDH Gene

This gene was present in the common ancestor of animals.

Orthologs for ASPDH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ASPDH 33 34
  • 99.53 (n)
dog
(Canis familiaris)
Mammalia ASPDH 33 34
  • 87.43 (n)
mouse
(Mus musculus)
Mammalia Aspdh 33 16 34
  • 86.09 (n)
cow
(Bos Taurus)
Mammalia ASPDH 34
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aspdh 33
  • 84.69 (n)
lizard
(Anolis carolinensis)
Reptilia ASPDH 34
  • 53 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii aspdh 33 34
  • 53.33 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_F17C8.9 33
  • 49.04 (n)
F17C8.9 34
  • 45 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 47 (a)
OneToOne
Species where no ortholog for ASPDH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ASPDH Gene

ENSEMBL:
Gene Tree for ASPDH (if available)
TreeFam:
Gene Tree for ASPDH (if available)

Paralogs for ASPDH Gene

No data available for Paralogs for ASPDH Gene

Variants for ASPDH Gene

Sequence variations from dbSNP and Humsavar for ASPDH Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000767299 -- 50,512,896(+) GCAGG(A/G)CTCTG intron-variant, upstream-variant-2KB
rs1001688377 -- 50,514,533(+) CAGTG(A/T)GACGT upstream-variant-2KB, utr-variant-5-prime
rs1002035677 -- 50,516,459(+) TGGAC(A/G)CAGAC downstream-variant-500B, upstream-variant-2KB
rs1003097628 -- 50,515,521(+) ACCGG(C/T)CAGAA upstream-variant-2KB
rs1003570295 -- 50,516,573(+) GCTGG(C/T)GAGGC downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ASPDH Gene

Variant ID Type Subtype PubMed ID
nsv1133010 OTHER inversion 24896259
nsv1140251 OTHER inversion 24896259
nsv1152956 OTHER inversion 26484159
nsv509750 CNV insertion 20534489
nsv953604 CNV deletion 24416366

Variation tolerance for ASPDH Gene

Residual Variation Intolerance Score: 61.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.77; 58.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ASPDH Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ASPDH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASPDH Gene

Disorders for ASPDH Gene

Relevant External Links for ASPDH

Genetic Association Database (GAD)
ASPDH
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ASPDH

No disorders were found for ASPDH Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASPDH Gene

Publications for ASPDH Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 60
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 60
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 60

Products for ASPDH Gene

Sources for ASPDH Gene

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