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Aliases for ASPDH Gene

Aliases for ASPDH Gene

  • Aspartate Dehydrogenase Domain Containing 2 3
  • Aspartate Dehydrogenase Domain-Containing Protein 4
  • EC 4

External Ids for ASPDH Gene

Previous GeneCards Identifiers for ASPDH Gene

  • GC19M055710
  • GC19M051014
  • GC19M047351

Summaries for ASPDH Gene

GeneCards Summary for ASPDH Gene

ASPDH (Aspartate Dehydrogenase Domain Containing) is a Protein Coding gene. GO annotations related to this gene include NADP binding and aspartate dehydrogenase activity.

UniProtKB/Swiss-Prot for ASPDH Gene

  • Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASPDH Gene

Genomics for ASPDH Gene

Regulatory Elements for ASPDH Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ASPDH Gene

50,511,600 bp from pter
50,515,432 bp from pter
3,833 bases
Minus strand

Genomic View for ASPDH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ASPDH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASPDH Gene

Proteins for ASPDH Gene

  • Protein details for ASPDH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative L-aspartate dehydrogenase
    Protein Accession:
    Secondary Accessions:
    • Q6NZ37

    Protein attributes for ASPDH Gene

    283 amino acids
    Molecular mass:
    29946 Da
    Quaternary structure:
    No Data Available
    • The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.

    Alternative splice isoforms for ASPDH Gene


neXtProt entry for ASPDH Gene

Proteomics data for ASPDH Gene at MOPED

Post-translational modifications for ASPDH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ASPDH Gene

Antibody Products

No data available for DME Specific Peptides for ASPDH Gene

Domains for ASPDH Gene

Protein Domains for ASPDH Gene

Suggested Antigen Peptide Sequences for ASPDH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the L-aspartate dehydrogenase family.
  • Belongs to the L-aspartate dehydrogenase family.
genes like me logo Genes that share domains with ASPDH: view

No data available for Gene Families for ASPDH Gene

Function for ASPDH Gene

Molecular function for ASPDH Gene

UniProtKB/Swiss-Prot CatalyticActivity:
L-aspartate + H(2)O + NAD(P)(+) = oxaloacetate + NH(3) + NAD(P)H
UniProtKB/Swiss-Prot Function:
Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.

Enzyme Numbers (IUBMB) for ASPDH Gene

Gene Ontology (GO) - Molecular Function for ASPDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity --
GO:0033735 aspartate dehydrogenase activity IEA --
GO:0050661 NADP binding IEA --
genes like me logo Genes that share ontologies with ASPDH: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ASPDH

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ASPDH Gene

Localization for ASPDH Gene

Subcellular locations from

Jensen Localization Image for ASPDH Gene COMPARTMENTS Subcellular localization image for ASPDH gene
Compartment Confidence
mitochondrion 3
nucleus 2
cytosol 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ASPDH Gene

Pathways for ASPDH Gene

SuperPathways for ASPDH Gene

No Data Available

UniProtKB/Swiss-Prot A6ND91-ASPD_HUMAN

  • Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (dehydrogenase route): step 1/1

Interacting Proteins for ASPDH Gene

Gene Ontology (GO) - Biological Process for ASPDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006742 NADP catabolic process IEA --
GO:0009435 NAD biosynthetic process IEA --
GO:0019363 pyridine nucleotide biosynthetic process --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with ASPDH: view

No data available for Pathways by source for ASPDH Gene

Drugs for ASPDH Gene

(7) HMDB Compounds for ASPDH Gene

Compound Synonyms Cas Number PubMed IDs
  • Ammonia anhydrous
Iminoaspartic acid
  • alpha-Iminosuccinate
L-Aspartic acid
  • Asp
  • 3-Carbamoyl-1-beta-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate inner salt
  • Adenine-nicotinamide dinucleotide phosphate
genes like me logo Genes that share compounds with ASPDH: view

Transcripts for ASPDH Gene

mRNA/cDNA for ASPDH Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ASPDH Gene

Aspartate dehydrogenase domain containing:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ASPDH

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ASPDH Gene

No ASD Table

Relevant External Links for ASPDH Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ASPDH Gene

mRNA expression in normal human tissues for ASPDH Gene

mRNA differential expression in normal tissues according to GTEx for ASPDH Gene

This gene is overexpressed in Liver (12.3).

Protein differential expression in normal tissues for ASPDH Gene

This gene is overexpressed in Gallbladder (12.8), Nasal epithelium (9.7), Monocytes (8.4), Neutrophil (8.1), Esophagus (7.4), and Liver, secretome (7.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ASPDH Gene

SOURCE GeneReport for Unigene cluster for ASPDH Gene Hs.436338

genes like me logo Genes that share expressions with ASPDH: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Expression partners for ASPDH Gene

Orthologs for ASPDH Gene

This gene was present in the common ancestor of animals.

Orthologs for ASPDH Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia ASPDH 35
  • 87.43 (n)
  • 87.19 (a)
  • 85 (a)
(Mus musculus)
Mammalia Aspdh 35
  • 86.09 (n)
  • 89.21 (a)
Aspdh 16
Aspdh 36
  • 86 (a)
(Pan troglodytes)
Mammalia ASPDH 35
  • 99.53 (n)
  • 98.94 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Aspdh 35
  • 84.69 (n)
  • 88.34 (a)
(Bos Taurus)
Mammalia ASPDH 36
  • 85 (a)
(Anolis carolinensis)
Reptilia ASPDH 36
  • 53 (a)
(Danio rerio)
Actinopterygii aspdh 35
  • 53.33 (n)
  • 49.82 (a)
aspdh 36
  • 48 (a)
(Caenorhabditis elegans)
Secernentea CELE_F17C8.9 35
  • 49.04 (n)
  • 47.89 (a)
F17C8.9 36
  • 45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
Species with no ortholog for ASPDH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ASPDH Gene

Gene Tree for ASPDH (if available)
Gene Tree for ASPDH (if available)

Paralogs for ASPDH Gene

No data available for Paralogs for ASPDH Gene

Variants for ASPDH Gene

Sequence variations from dbSNP and Humsavar for ASPDH Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs889131 -- 50,514,578(+) CTCGC(A/G)TCAGC utr-variant-5-prime, upstream-variant-2KB, reference, missense
rs1644735 -- 50,515,518(+) TGAAC(C/T)GGCCA upstream-variant-2KB
rs1644736 -- 50,515,556(+) CGCAG(C/G)CCCAG upstream-variant-2KB
rs1644737 -- 50,515,604(+) CTCTG(C/G)AGCAG upstream-variant-2KB
rs1673021 -- 50,515,407(-) AACCC(C/T)GAGCG upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ASPDH Gene

Variant ID Type Subtype PubMed ID
nsv912282 CNV Loss 21882294
nsv509750 CNV Insertion 20534489
nsv912283 CNV Gain 21882294
nsv912284 CNV Loss 21882294

Relevant External Links for ASPDH Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASPDH Gene

Disorders for ASPDH Gene

Relevant External Links for ASPDH

Genetic Association Database (GAD)

No disorders were found for ASPDH Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ASPDH Gene

Publications for ASPDH Gene

  1. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for ASPDH Gene

Sources for ASPDH Gene

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