ASPA Gene
protein-coding GIFtS: 65
GCID: GC17P003326
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|
aspartoacylase(Previous names: aspartoacylase (aminoacylase 2, Canavan disease) )
| |
Aliases
for ASPA gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Aspartoacylase1 | | Aspartoacylase (Aminoacylase 2, Canavan Disease)1 | | ACY21 2 3 | | Aminoacylase 22 | | ASP1 2 3 | | Aminoacylase-23 | | ACY-22 3 | | Aminoacylase-23 | | EC 3.5.1.153 8 | | |
Export aliases for ASPA gene to outside databasesPrevious GC identifers: GC17P003693 GC17P003330 GC17P003585 GC17P003269 |
Summaries
for ASPA gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ASPA:
This gene encodes an enzyme that catalyzes the conversion of N-acetyl_L-aspartic acid (NAA) to aspartate and acetate.NAA is abundant in the brain where hydrolysis by aspartoacylase is thought to help maintain white matter. This proteinis an NAA scavenger in other tissues. Mutations in this gene cause Canavan disease. Alternatively spliced transcriptvariants have been found for this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: ACY2_HUMAN, P45381Function: Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs inhigh concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter.In other tissues it act as a scavenger of NAA from body fluids
|
Genomic Views
for ASPA gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ASPA gene promoter:
Elk-1 AML1a LyF-1 Cdc5 YY1 Evi-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ASPA
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASPA |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p13.3 Ensembl cytogenetic band: 17p13.2 HGNC cytogenetic band: 17p13.3ASPA Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P003326: view genomic region
(about GC identifiers)
Start:
|
3,375,668 bp from pter |
End:
|
3,406,713 bp from pter |
Size:
|
31,046 bases |
Orientation:
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plus strand |
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Proteins
for ASPA gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ACY2_HUMAN, P45381 (See
protein sequence)Recommended Name: Aspartoacylase Size: 313 amino acids; 35735 Da
Cofactor: Binds 1 zinc ion per subunit
Subunit: Homodimer (Probable)
Subcellular location: Cytoplasm. Nucleus (By similarity)
4 PDB 3D structures from  and Proteopedia  for ASPA:2I3C (3D)
2O4H (3D)
2O53 (3D)
2Q51 (3D)
Explore the universe of human proteins at neXtProt for ASPA: NX_P45381
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P45381
4/11 DME Specific Peptides for ASPA (P45381) (see all 11)
ASPA Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_000040.1 NP_001121557.1
ENSEMBL proteins: ENSP00000458324 ENSP00000409976 ENSP00000263080 ENSP00000461358
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ASPA for ontologies About GeneDecksing
ASPA Antibody Products:
Assay Products for ASPA: |
Protein
Domains /
Families
for ASPA gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ASPA for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P45381ProtoNet protein and cluster: P45381 1 Blocks protein family: IPB007036 Succinylglutamate desuccinylase/aspartoacylase
UniProtKB/Swiss-Prot: ACY2_HUMAN, P45381Similarity: Belongs to the AspA/AstE family. Aspartoacylase subfamily |
Function
for ASPA gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ACY2_HUMAN, P45381Function: Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs inhigh concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter.In other tissues it act as a scavenger of NAA from body fluidsCatalytic activity: N-acyl-L-aspartate + H(2)O = a carboxylate + L-aspartate Genatlas biochemistry entry for ASPA:aspartoacylase,36kDa,expressed in skeletal muscle,kidney,brain,hydrolyzing preferentially N-acetyl-L-aspartic acid
Enzyme Number (IUBMB): EC 3.5.1.151 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASPA (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASPA (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ASPA (NM_001128085) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ASPA | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASPA |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASPA |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
ASPA for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for ASPA:
Animal Models:
Mouse knock-out Aspatm1Mata for ASPA
11 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Aspa):
ASPA for phenotypes About GeneDecksing
|
Pathways & Interactions
for ASPA gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Alanine, aspartate and glutamate metabolism | | | 2 | Histidine metabolism | | | 3 | alanine degradation III | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for ASPA
2 
Kegg Pathways (Kegg details for ASPA):
ASPA for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ASPA
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/29 Interacting proteins for ASPA (P453812 ENSP000002630804) via UniProtKB, MINT, STRING, and/or I2D (see all 29)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006533 | aspartate catabolic process |
TAS | 8252036 | | GO:0022010 | central nervous system myelination |
IEA | -- | | GO:0048714 | positive regulation of oligodendrocyte differentiation |
IEA | -- |
ASPA for ontologies About GeneDecksing
|
Drugs & Compounds
for ASPA gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ASPA for compounds About GeneDecksing
 Browse Tocris compounds for ASPA
10/14 HMDB Compounds for ASPA (see all 14) About this table
1 DrugBank Compound for ASPA About this table
9 Novoseek chemical compound relationships for ASPA gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| n-acetylaspartate |
91.6 |
91 |
8295397 (2), 19319678 (2), 10894262 (2), 15857674 (2) (see all 42) |
| n-acetyl-aspartyl-glutamate |
76.5 |
1 |
15246864 (1) |
| aspartate |
59 |
15 |
16669630 (1), 17632691 (1), 18293939 (1), 16707098 (1) (see all 12) |
| acetyl-coa |
34.2 |
2 |
16647192 (1), 16730130 (1) |
| glutamate |
29.6 |
2 |
18433445 (1), 15246864 (1) |
| carboxylate |
20 |
1 |
17027983 (1) |
| zinc |
6.88 |
5 |
16669630 (1), 17027983 (1), 17391648 (1), 17194761 (1) |
| lipid |
0 |
6 |
16647192 (2), 17254025 (1), 15784740 (1), 19685155 (1) |
| fatty acid |
0 |
2 |
12670701 (1), 17275978 (1) |
Search CenterWatch for drugs/clinical trials and news about ASPA / ACY2
|
Transcripts
for ASPA gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ASPA gene (2 alternative transcripts): NM_000049.2 NM_001128085.1 Unigene Cluster for ASPA: Aspartoacylase Hs.171142 [show with all ESTs]Unigene Representative Sequence: BC0291284 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000577034 ENST00000456349 ENST00000263080(uc010ckg.3 uc002fvq.3)
ENST00000571278
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASPA (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASPA (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ASPA (NM_001128085) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ASPA | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASPA |
Additional cDNA sequence: AK312901.1 BC010941.1 BC029128.1 CR541908.1 S67156.1 2 DOTS entries: DT.410219 DT.99959714 24/38 AceView cDNA sequences (see all 38): BX280301 CR541908 BC029128 H24491 H99458 BG428490 BI762332 AI522292 BI561787 S67156 NM_000049 AL703699 BC010941 AI888020 BP360924 AA860932 BI823975 AI767553 AI830459 AI798654 BF115120 AA112139 AW298248 H99457
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for ASPA About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ASPA
|
Expression
for ASPA gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ASPA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATACTTGGGT
About this image
See ASPA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ASPA
SOURCE GeneReport for Unigene cluster: Hs.171142
UniProtKB/Swiss-Prot: ACY2_HUMAN, P45381Tissue specificity: Brain white matter, skeletal muscle, kidney, adrenal glands, lung and liver
SABiosciences Expression via Pathway-Focused PCR Arrays including ASPA:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ASPA
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ASPA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ASPA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASPA | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASPA |
Orthologs
for ASPA gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ASPA gene from 4/13 species (see all 13) About this table
ENSEMBL Gene Tree for ASPA (if available)
TreeFam Gene Tree for ASPA (if available) |
Paralogs
for ASPA gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ASPA gene
- ACY32
2 SIMAP similar genes for ASPA using alignment to 4 protein entries: ACY2_HUMAN (see all proteins):ACY3 HCBP1
ASPA for paralogs About GeneDecksing
|
Genomic Variants
for ASPA gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ASPA (3375668 - 3406713 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ASPA: --
Human Gene Mutation Database (HGMD): ASPA
Locus Specific Mutation Databases (LSDB): ASPA
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ASPA |
|
Disorders
/ Diseases
for ASPA gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ASPA for disorders About GeneDecksing
OMIM gene information: 608034
OMIM disorders: 271900
UniProtKB/Swiss-Prot: ACY2_HUMAN, P45381
Defects in ASPA are the cause of Canavan disease (CAND) [MIM:271900]; also known as spongy degeneration of thebrain. CAND is a rare neurodegenerative condition of infancy or childhood characterized by white matter vacuolizationand demeylination that gives rise to a spongy appearance. The clinical features are onset in early infancy, atonia ofneck muscles, hypotonia, hyperextension of legs and flexion of arms, blindness, severe mental defect, megalocephaly,and death by 18 months on the average
20  diseases for ASPA: About MalaCardscanavan disease succinic semialdehyde dehydrogenase deficiency type 2 diabetes mellitus autism spectrum disorder
cortical blindness intellectual disability leukodystrophy diabetes mellitus
neurodegenerative disease diabetic neuropathy tremor neurologic diseases
blindness neuropathy hypotonia seizures
obesity cerebritis retinitis neuronitis
3 diseases from the University of Copenhagen DISEASES database for ASPA:Canavan disease Ascaridiasis Ancylostomiasis 10/11 Novoseek disease relationships for ASPA gene (see all 11) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| canavan disease |
99.2 |
146 |
8088831 (4), 16802706 (3), 12162821 (3), 2309767 (3) (see all 72) |
| leukodystrophy |
94.5 |
23 |
2309767 (2), 10894262 (1), 17275978 (1), 8023850 (1) (see all 14) |
| macrocephaly |
85.2 |
1 |
10894262 (1) |
| enzyme deficiency |
67 |
5 |
12638939 (1), 15686967 (1), 15907664 (1) |
| severe mental retardation |
66.6 |
2 |
10894262 (1) |
| neurodegenerative diseases |
57.4 |
10 |
7668285 (1), 16854607 (1), 19764455 (1), 17027983 (1) (see all 9) |
| developmental delay |
53.9 |
2 |
16113575 (1) |
| mental retardation |
36.6 |
1 |
16121806 (1) |
| genetic disorder |
33.9 |
2 |
15784740 (1), 19685155 (1) |
| neurological disorders |
9.62 |
3 |
18293939 (1), 10894213 (1) |
GeneTests: ASPA
Canavan Disease
Genetic Association Database (GAD): ASPA
Human Genome Epidemiology (HuGE) Navigator: ASPA (8 documents)
Export disorders for ASPA gene to outside databases
|
Publications
for ASPA gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ASPA gene, integrated from 9 sources (see all 120):
(articles sorted by number of sources associating them with ASPA) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Structure of aspartoacylase, the brain enzyme impaired in Canavan disease. (PubMed id 17194761)1, 2, 7, 9 Bitto E.... Phillips G.N. Jr. (2007)
- Cloning of the human aspartoacylase cDNA and a common missense mutation in Canavan disease. (PubMed id 8252036)1, 2, 3, 9 Kaul R.... Matalon R. (1993)
- Canavan disease: mutations among Jewish and non-Jewish patients. (PubMed id 8023850)1, 2, 9 Kaul R....Matalon R. (1994)
- Identification of the zinc binding ligands and the catalytic residue in human aspartoacylase, an enzyme involved in Canavan disease. (PubMed id 17027983)1, 2, 9 Herga S....Giardina T. (2006)
- Purification and preliminary characterization of brain aspartoacylase. (PubMed id 12706335)1, 2, 9 Moore R.A.... Viola R.E. (2003)
- Identification and characterization of novel mutations of the aspartoacylase gene in non-Jewish patients with Canavan disease. (PubMed id 12638939)1, 2, 9 Zeng B.J.... Kolodny E.H. (2002)
- Identification and expression of eight novel mutations among non- Jewish patients with Canavan disease. (PubMed id 8659549)1, 2, 9 Kaul R.... Clarke J.T.R. (1996)
- The molecular basis of canavan (aspartoacylase deficiency) disease in European non-Jewish patients. (PubMed id 7668285)1, 2, 9 Shaag A....Elpeleg O.N. (1995)
- Two novel aspartoacylase gene (ASPA) missense mutations specific to Norwegian and Swedish patients with Canavan disease. (PubMed id 12205125)1, 2, 9 Olsen T.R....Nilssen O. (2002)
- Examination of the mechanism of human brain aspartoacylase through the binding of an intermediate analogue. (PubMed id 18293939)1, 2, 9 Le Coq J.... Viola R.E. (2008)
|
External Searches for ASPA gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ASPA gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ASPA gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ASPA gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ASPA | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/ASPA |
|
| | |
About This Section
| Patent Information for ASPA gene:
Search GeneIP for patents involving ASPA
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ASPA gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | OriGene Antibodies for ASPA | | OriGene shRNA RFP for ASPA | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ASPA | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ASPA | | | OriGene Protein Over-expression Lysate for ASPA | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ASPA | | OriGene 3'-UTR Clone for ASPA | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASPA | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASPA | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ASPA | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ASPA | | OriGene Custom Protein Services for ASPA | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ASPA | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ASPA | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASPA | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ASPA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASPA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ASPA |
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| | | | Search Tocris compounds for ASPA |
| |  |  |  |  | | | | | | Recombinant Protein for ASPA |
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 | | | ASPA Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASPA |
|  |  |  | | | | ThermoFisher Antibody for ASPA |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASPA |
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