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ASPA Gene

protein-coding GIFtS: 63

GC17P003326

aspartoacylase (Canavan disease)
(Previous names: aspartoacylase (aminoacylase 2, Canavan disease) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ACY-2 ^³
ACY2 ^¹, ², ³
ASP ^¹, ², ³
Aminoacylase-2 ^³
EC 3.5.1.15 ^³
aspartoacylase ^²

Descriptions
aminoacylase 2 ^²
aspartoacylase (Canavan disease) ^²
aspartoacylase (aminoacylase 2, Canavan disease) ^¹

External Ids
HGNC: 756¹
Entrez Gene: 443²
UniProtKB: P45381³
Ensembl: ENSG00000108381⁷

Search outside databases for aliases for ASPA gene

Previous GC identifers: GC17P003693 GC17P003330 GC17P003585

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ASPA:

This gene encodes an enzyme that catalyzes the conversion of N-acetyl_L-aspartic acid (NAA) to

aspartate and acetate. NAA is abundant in the brain where hydrolysis by aspartoacylase is thought

to help maintain white matter. This protein is an NAA scavenger in other tissues. Mutations in

this gene cause Canavan disease. Alternatively spliced transcript variants have been found for

this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: ACY2_HUMAN, P45381

Function: Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and

L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant

part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from

body fluids

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ASPA gene

Entrez Gene cytogenetic band: 17pter-p13 Ensembl cytogenetic band: 17p13.3 HGNC cytogenetic band: 17p13.3

ASPA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P003326: (about GC identifiers)

Start:	3,326,046 bp from pter
End:	3,349,450 bp from pter
Size:	23,405 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000017.9 NT_010718.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ACY2_HUMAN, P45381 (See protein sequence)

Recommended Name: Aspartoacylase

Size: 313 amino acids; 35735 Da

Cofactor: Binds 1 zinc ion per subunit

Subunit: Homodimer (Probable)

Subcellular location: Cytoplasm. Nucleus (By similarity)

PDB structures from and Proteopedia :

2I3C (3D)

2O4H (3D)

2O53 (3D)

2Q51 (3D)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_000040.1 NP_001121557.1

ENSEMBL proteins:

ENSP00000263080

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ASPA)
	Human Recombinant Proteins from Abnova (ASPA)

OriGene Purified Recombinant Human Protein: ASPA

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--

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Antibodies for ASPA:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ASPA
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ASPA), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ASPA)
	Novus Biologicals Antibodies for ASPA

Assays for ASPA:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P45381

ProtoNet protein and cluster: P45381

1 Blocks protein family: IPB007036 Succinylglutamate desuccinylase/aspartoacylase

UniProtKB/Swiss-Prot: ACY2_HUMAN, P45381

Similarity: Belongs to the aspA/astE family. Aspartoacylase subfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ASPA)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ASPA)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000049

Applied Biosystems Silencer® siRNAs for ASPA

Sigma-Aldrich siRNA and siRNA Panels for ASPA

Sigma-Aldrich shRNA for ASPA

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ASPA
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000049
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000049
untagged cDNA clones in CMV expression vector (see all 2): NM_000049

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001128085

UniProtKB/Swiss-Prot: ACY2_HUMAN, P45381

Function: Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and

L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant

part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from

body fluids

Catalytic activity: N-acyl-L-aspartate + H(2)O = a carboxylate + L-aspartate

Enzyme Number (IUBMB): EC 3.5.1.15

Genatlas biochemistry entry for ASPA:

aspartoacylase,36kDa,expressed in skeletal muscle,kidney,brain,hydrolyzing preferentially

N-acetyl-L-aspartic acid

10 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Aspa):

adipose tissue	behavior/neurological	craniofacial	growth/size	lethality-postnatal
life span-post-weaning/aging	nervous system	skeleton	touch/vibrissae	vision/eye

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004046	aminoacylase activity	TAS	8252036
GO:0008270	zinc ion binding	IEA	--
GO:0016788	hydrolase activity, acting on ester bonds	IEA	--
GO:0019807	aspartoacylase activity	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

3 Sigma-Aldrich "Your Favorite Gene" Pathways for ASPA (Your Favorite Gene powered by Ingenuity)

Histidine Metabolism
Urea Cycle and Metabolism of Amino Groups
Alanine and Aspartate Metabolism

GeneDecks ASPA for the pathways selected above

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1 Interacting protein for ASPA (P45381²) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
ASPA P45381² MINT-67799
About this table
2 Gene Ontology (GO) biological process terms (links to tree view):
GO ID Qualified GO term Evidence PubMed IDs
GO:0006533 aspartate catabolic process TAS 8252036
GO:0008152 metabolic process IEA --
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ASPA
6 Novoseek chemical compound relationships for ASPA gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
n-acetylaspartate	91.67	86	8295397 (2), 10894262 (2), 15857674 (2), 16707098 (2) (see all 39)
acetyl-coa	36.20	2	16647192 (1), 16730130 (1)
carboxylate	22.35	1	17027983 (1)
zinc	9.04	5	16669630 (1), 17027983 (1), 17391648 (1), 17194761 (1)
lipid	0.00	5	16647192 (2), 17254025 (1), 15784740 (1)
fatty acid	0.00	2	12670701 (1), 17275978 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ASPA)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ASPA)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000049

Sigma-Aldrich siRNA and siRNA Panels for ASPA

Sigma-Aldrich shRNA for ASPA

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000049 NM_001128085

REFSEQ mRNAs for ASPA gene (2 alternative transcripts):

NM_000049.2 NM_001128085.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000049 NM_001128085

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000049
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000049
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_000049

Additional cDNA sequence:

AK312901.1 BC010941.1 BC029128.1 CR541908.1 S67156.1

2 DOTS entries:

DT.410219 DT.99959714

24/38 AceView cDNA sequences (see all 38 ):

CR541908 H24491 BX280301 BC029128 S67156 NM_000049 AA860932 BI561787

AA112139 AL703699 AI798654 AI830459 AW298248 H99458 BF115120 BC010941

BI762332 BP360924 BG428490 AI522292 BI823975 AI767553 AI888020 AI309783

highest scoring ESTs for ASPA:

S67156 AA909573 AI283796 AI309783 AI522292 AI767553 AI798654 AI830459 AI888020 AV723785

Unigene Cluster for ASPA:

Aspartoacylase (Canavan disease)

Hs.171142 [show with all ESTs]

Unigene Representative Sequence: BC029128

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for ASPA

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7a	·	7b	·	7c
SP1:
SP2:															-
SP3:

About this scheme

ECgene alternative splicing isoforms for ASPA

1 Ensembl transcript including schematic representation:

ENST00000263080

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ASPA expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ASPA

¹ / ² / ³

3 probe-sets matching ASPA gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39654_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	S67156	1.00	1.00	1.00	1
206030_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000049	0.60	1.00	0.82	1
206030_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ASPA for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ATACTTGGGT

SOURCE GeneReport for Unigene cluster: Hs.171142
Expression variation in blood from EXPOLDB for ASPA
UniProtKB/Swiss-Prot: ACY2_HUMAN, P45381
Tissue specificity: Brain white matter, skeletal muscle, kidney, adrenal glands, lung and liver

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ASPA gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ASPA¹	--	aspartoacylase (Canavan disease)	90.73(n) 90.42(a)	611064 XM_863442.1 XP_868535.1
chimpanzee (Pan troglodytes)	ASPA¹	--	aspartoacylase (Canavan disease)	99.57(n) 100(a)	454430 XM_001158110.1 XP_001158110.1
cow (Bos taurus)	ASPA¹	--	aspartoacylase (Canavan disease)	90.38(n) 92.44(a)	509432 NM_001046033.1 NP_001039498.1
rat (Rattus norvegicus)	Aspa¹	--	aspartoacylase	85.58(n) 86.86(a)	79251 NM_024399.1 NP_077375.1
mouse (Mus musculus)	Aspa^{1, 5}	11 (34.00 cM)⁵	aspartoacylase^{1, 5}	86.75(n)¹ 86.54(a)¹	11484¹ NM_023113.4¹ NP_075602.2¹ AA068581⁵ AF212998⁵ (see all 14)

About this table Species with no ortholog for ASPA

ENSEMBL Gene Tree for ASPA

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ASPA gene

ACY3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/167 NCBI SNPs in ASPA are shown (see all 167 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 90)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs11078451^1,2	A,C,F,H	3324493(+)	`ACCATG/AGTTAC`	1	--	ng5¹ tfbs³		12	EU EA WA	1254
	rs11078450^1,2	A,C,F,H	3324146(+)	`CTCTAC/GTTCTG`	1	--	ng5¹		4	EU EA WA	418
--	rs12948217^1,2	A,C,F	3344452(+)	`GATTAA/C/TCCCCG`	4	Y/X Y/Y	non¹ syn¹ ese³		4	NA MN	324
	rs3829957^1,2	C,F,H	3325626(+)	`GGCGCC/TGGTTC`	1	--	ng5¹		4	EU EA WA	418
	rs9896885^1,2	F,H	3349135(+)	`TAGAAA/GTCACT`	2	--	ut3¹		4	EU EA WA	420
	rs3814886^1,2	F,H	3324691(+)	`TCTCTA/GTCTCT`	1	--	ng5¹		5	EA EU WA	1894
	rs8069497^1,2	H	3324089(+)	`GGAGTT/AAAAAA`	1	--	ng5¹		4	EU EA WA	416
	rs28940279^1,2	C	3349044(+)	`GAATGA/CGGCCG`	2	E/A	mis¹ ese³		1	NA	74
--	rs1552830^1,2	C	3349271(+)	`aagcaA/Catttc`	2	--	ut3¹		1	MN	184
	rs2131517^1,2	A,C,F,H,O	3338200(+)	`GTAAAT/AGGTTT`	1	--	int¹		7	NA EU EA WA	562

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HapMap Linkage Disequilibrium images for ASPA (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 608034 disorders: 271900

UniProtKB/Swiss-Prot: ACY2_HUMAN, P45381

Defects in ASPA are the cause of Canavan disease (CAND) [MIM:271900]; also known as spongy

degeneration of the brain. CAND is a rare neurodegenerative condition of infancy or childhood

characterized by white matter vacuolization and demeylination that gives rise to a spongy

appearance. The clinical features are onset in early infancy, atonia of neck muscles, hypotonia,

hyperextension of legs and flexion of arms, blindness, severe mental defect, megalocephaly, and

death by 18 months on the average

10/11 Novoseek disease relationships for ASPA gene (see all 11 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
canavan disease	99.22	136	8088831 (4), 16802706 (3), 12162821 (3), 17391648 (3) (see all 68)
leukodystrophy	94.59	23	2309767 (2), 10894262 (1), 17275978 (1), 8023850 (1) (see all 14)
macrocephaly	85.99	1	10894262 (1)
enzyme deficiency	68.02	5	12638939 (1), 15686967 (1), 15907664 (1)
severe mental retardation	64.12	2	10894262 (1)
neurodegenerative diseases	58.33	9	7668285 (1), 16854607 (1), 17027983 (1), 17391648 (1) (see all 8)
developmental delay	55.78	2	16113575 (1)
mental retardation	33.03	1	16121806 (1)
genetic disorder	20.58	1	15784740 (1)
neurological disorders	12.17	3	18293939 (1), 10894213 (1)

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GeneTests: ASPA

Canavan Disease

Human Gene Mutation Database: ASPA
Genetic Association Database: ASPA
Human Genome Epidemiology Navigator: ASPA (4 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/106 PubMed articles for ASPA gene (see all 106 ):

Cloning of the human aspartoacylase cDNA and a common missense mutation in Canavan disease. (PubMed id 8252036)^{1, 2, 3, 4} Kaul R.... Matalon R. (1993)
Structure of aspartoacylase, the brain enzyme impaired in Canavan disease. (PubMed id 17194761)^{1, 3, 4} Bitto E....Phillips G.N. (2007)
Canavan disease: mutations among Jewish and non-Jewish patients. (PubMed id 8023850)^{1, 3, 4} Kaul R....Matalon R. (1994)
Purification and preliminary characterization of brain aspartoacylase. (PubMed id 12706335)^{1, 3, 4} Moore R.A.... Viola R.E. (2003)
Identification and characterization of novel mutations of the aspartoacylase gene in non-Jewish patients with Canavan disease. (PubMed id 12638939)^{1, 3, 4} Zeng B.J.... Kolodny E.H. (2002)
Identification and expression of eight novel mutations among non- Jewish patients with Canavan disease. (PubMed id 8659549)^{1, 3, 4} Kaul R.... Clarke J.T.R. (1996)
The molecular basis of canavan (aspartoacylase deficiency) disease in European non-Jewish patients. (PubMed id 7668285)^{1, 3, 4} Shaag A....Elpeleg O.N. (1995)
Two novel aspartoacylase gene (ASPA) missense mutations specific to Norwegian and Swedish patients with Canavan disease. (PubMed id 12205125)^{1, 3, 4} Olsen T.R....Nilssen O. (2002)
Examination of the mechanism of human brain aspartoacylase through the binding of an intermediate analogue. (PubMed id 18293939)^{1, 3, 4} Le Coq J....Viola R.E. (2008)
Canavan disease: carrier-frequency determination in the Ashkenazi Jewish population and development of a novel molecular diagnostic assay. (PubMed id 14699612)^{3, 6} Feigenbaum A....Stockley T.L. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 443	HGNC: 756	AceView: ASPA	Ensembl:ENSG00000108381	euGenes: HUgn443
ECgene: ASPA	H-InvDB: ASPA

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
GeneReviews	http://www.genetests.org/query?gene=ASPA

Licensable Technologies for ASPA
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ASPA:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ASPA-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ASPA		Antibodies for ASPA
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ASPA		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ASPA)
	Antibodies (ASPA)
	Chimera RNAi (ASPA)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (ASPA)
	Antibodies (ASPA)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for ASPA

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ASPA

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ASPA Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for ASPA

Summaries
for ASPA

Genomic Location
for ASPA

Proteins
for ASPA

Protein Domains/
Families
for ASPA

Gene Function
for ASPA

Pathways & Interactions
for ASPA

Drugs & Compounds
for ASPA

Transcripts
for ASPA

Expression
for ASPA

Orthologs
for ASPA

Paralogs
for ASPA

SNPs/Variants
for ASPA

Disorders & Mutations
for ASPA

Medical News
for ASPA

Publications
for ASPA

Search for ASPA

Genome Databases showing ASPA

Other Databases showing ASPA

Specialized Databases showing ASPA

Licensable Technologies
for ASPA

Services
for ASPA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ASPA Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor ASPA

Summariesfor ASPA

Genomic Locationfor ASPA

Proteinsfor ASPA

Protein Domains/Familiesfor ASPA

Gene Functionfor ASPA

Pathways & Interactionsfor ASPA

Drugs & Compoundsfor ASPA

Transcriptsfor ASPA

Expression for ASPA

Orthologsfor ASPA

Paralogsfor ASPA

SNPs/Variantsfor ASPA

Disorders & Mutationsfor ASPA

Medical Newsfor ASPA

Publicationsfor ASPA

Search for ASPA

Genome Databases showing ASPA

Other Databases showing ASPA

Specialized Databases showing ASPA

Licensable Technologiesfor ASPA

Servicesfor ASPA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ASPA

Summaries
for ASPA

Genomic Location
for ASPA

Proteins
for ASPA

Protein Domains/
Families
for ASPA

Gene Function
for ASPA

Pathways & Interactions
for ASPA

Drugs & Compounds
for ASPA

Transcripts
for ASPA

Expression
for ASPA

Orthologs
for ASPA

Paralogs
for ASPA

SNPs/Variants
for ASPA

Disorders & Mutations
for ASPA

Medical News
for ASPA

Publications
for ASPA

Licensable Technologies
for ASPA

Services
for ASPA