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Aliases for ASNSD1 Gene

Aliases for ASNSD1 Gene

  • Asparagine Synthetase Domain Containing 1 2 3 5
  • HCV NS3-Transactivated Protein 1 3 4
  • NS3TP1 3 4
  • NBLA00058 3

External Ids for ASNSD1 Gene

Previous GeneCards Identifiers for ASNSD1 Gene

  • GC02P190234
  • GC02P190526
  • GC02P182385

Summaries for ASNSD1 Gene

GeneCards Summary for ASNSD1 Gene

ASNSD1 (Asparagine Synthetase Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include asparagine synthase (glutamine-hydrolyzing) activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASNSD1 Gene

Genomics for ASNSD1 Gene

Regulatory Elements for ASNSD1 Gene

Promoters for ASNSD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ASNSD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ASNSD1 Gene

Chromosome:
2
Start:
189,661,385 bp from pter
End:
189,670,831 bp from pter
Size:
9,447 bases
Orientation:
Plus strand

Genomic View for ASNSD1 Gene

Genes around ASNSD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASNSD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASNSD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASNSD1 Gene

Proteins for ASNSD1 Gene

  • Protein details for ASNSD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWL6-ASND1_HUMAN
    Recommended name:
    Asparagine synthetase domain-containing protein 1
    Protein Accession:
    Q9NWL6
    Secondary Accessions:
    • D3DPH6
    • Q3LIC3
    • Q4ZG45

    Protein attributes for ASNSD1 Gene

    Size:
    643 amino acids
    Molecular mass:
    72080 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ASNSD1 Gene

Proteomics data for ASNSD1 Gene at MOPED

Post-translational modifications for ASNSD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ASNSD1 Gene

Domains & Families for ASNSD1 Gene

Protein Domains for ASNSD1 Gene

Suggested Antigen Peptide Sequences for ASNSD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NWL6

UniProtKB/Swiss-Prot:

ASND1_HUMAN :
  • Contains 1 asparagine synthetase domain.
Domain:
  • Contains 1 asparagine synthetase domain.
  • Contains 1 glutamine amidotransferase type-2 domain.
genes like me logo Genes that share domains with ASNSD1: view

No data available for Gene Families for ASNSD1 Gene

Function for ASNSD1 Gene

Gene Ontology (GO) - Molecular Function for ASNSD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042803 protein homodimerization activity IBA --
genes like me logo Genes that share ontologies with ASNSD1: view

Phenotypes for ASNSD1 Gene

genes like me logo Genes that share phenotypes with ASNSD1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ASNSD1

miRNA for ASNSD1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ASNSD1 Gene

Localization for ASNSD1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ASNSD1 Gene COMPARTMENTS Subcellular localization image for ASNSD1 gene
Compartment Confidence
cytosol 4
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ASNSD1 Gene

Pathways & Interactions for ASNSD1 Gene

SuperPathways for ASNSD1 Gene

No Data Available

Interacting Proteins for ASNSD1 Gene

Gene Ontology (GO) - Biological Process for ASNSD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006529 asparagine biosynthetic process IEA,IBA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ASNSD1: view

No data available for Pathways by source and SIGNOR curated interactions for ASNSD1 Gene

Drugs & Compounds for ASNSD1 Gene

No Compound Related Data Available

Transcripts for ASNSD1 Gene

Unigene Clusters for ASNSD1 Gene

Asparagine synthetase domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ASNSD1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: -
SP2:
SP3: - - - -
SP4: - -
SP5: - -
SP6: -
SP7:

Relevant External Links for ASNSD1 Gene

GeneLoc Exon Structure for
ASNSD1
ECgene alternative splicing isoforms for
ASNSD1

Expression for ASNSD1 Gene

mRNA expression in normal human tissues for ASNSD1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ASNSD1 Gene



SOURCE GeneReport for Unigene cluster for ASNSD1 Gene Hs.101364

genes like me logo Genes that share expression patterns with ASNSD1: view

Protein tissue co-expression partners for ASNSD1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ASNSD1 Gene

Orthologs for ASNSD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ASNSD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ASNSD1 36
  • 99 (a)
OneToOne
ASNSD1 35
  • 99.53 (n)
  • 99.53 (a)
cow
(Bos Taurus)
Mammalia ASNSD1 36
  • 82 (a)
OneToOne
ASNSD1 35
  • 86.47 (n)
  • 82.76 (a)
dog
(Canis familiaris)
Mammalia ASNSD1 35
  • 86.12 (n)
  • 80.91 (a)
ASNSD1 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Asnsd1 36
  • 77 (a)
OneToOne
Asnsd1 35
  • 80.78 (n)
  • 77 (a)
Asnsd1 16
oppossum
(Monodelphis domestica)
Mammalia ASNSD1 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ASNSD1 36
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Asnsd1 35
  • 80.09 (n)
  • 75.4 (a)
chicken
(Gallus gallus)
Aves ASNSD1 35
  • 66.93 (n)
  • 59.55 (a)
ASNSD1 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ASNSD1 36
  • 61 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.20871 35
tropical clawed frog
(Silurana tropicalis)
Amphibia asnsd1 35
  • 62.3 (n)
  • 60.53 (a)
Str.15869 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8980 35
zebrafish
(Danio rerio)
Actinopterygii asnsd1 35
  • 58.76 (n)
  • 58.15 (a)
sidz211o13.6 35
asnsd1 36
  • 57 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010492 35
  • 46.91 (n)
  • 38.91 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17486 35
  • 49.58 (n)
  • 38.73 (a)
CG17486 36
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea M18.3 36
  • 35 (a)
OneToOne
M18.3 35
  • 49.1 (n)
  • 41.63 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL350C 35
  • 44.18 (n)
  • 35.71 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YML096W 35
  • 45.86 (n)
  • 34.45 (a)
-- 36
  • 29 (a)
OneToOne
-- 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D10285g 35
  • 47.26 (n)
  • 35.45 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G03667 35
  • 51.07 (n)
  • 43.16 (a)
rice
(Oryza sativa)
Liliopsida Os.47110 35
Os12g0574900 35
  • 48.72 (n)
  • 43.46 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07300 35
  • 43.7 (n)
  • 38.15 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC4F6.11c 35
  • 46.35 (n)
  • 36.73 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToOne
Species with no ortholog for ASNSD1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ASNSD1 Gene

ENSEMBL:
Gene Tree for ASNSD1 (if available)
TreeFam:
Gene Tree for ASNSD1 (if available)

Paralogs for ASNSD1 Gene

No data available for Paralogs for ASNSD1 Gene

Variants for ASNSD1 Gene

Sequence variations from dbSNP and Humsavar for ASNSD1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1437880 - 189,666,700(+) TTTCC(A/G)GATGC reference, missense
rs35137531 - 189,667,433(-) CTTCC(A/G)TAGAA reference, missense
rs893782 -- 189,670,812(+) TATAA(C/T)ATAGT utr-variant-3-prime
rs893783 -- 189,670,960(+) ATGCG(G/T)TGACT downstream-variant-500B
rs1052662 -- 189,670,735(+) GATTC(A/C)CAATG utr-variant-3-prime

Variation tolerance for ASNSD1 Gene

Residual Variation Intolerance Score: 21.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.12; 38.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ASNSD1 Gene

HapMap Linkage Disequilibrium report
ASNSD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ASNSD1 Gene

Disorders for ASNSD1 Gene

Relevant External Links for ASNSD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ASNSD1

No disorders were found for ASNSD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASNSD1 Gene

Publications for ASNSD1 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 67
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. Construction of eukaryotic expression plasmid containing HCV NS3 segment and protein expression in human HL-7702 hepatocytes. (PMID: 16534843) Li J.W. … Huang Z.Q. (World J. Gastroenterol. 2006) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ASNSD1 Gene

Sources for ASNSD1 Gene

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