ASNSD1 Gene
protein-coding GIFtS: 44
GCID: GC02P190526
|
|
asparagine synthetase domain containing 1
| |
Aliases
for ASNSD1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Asparagine Synthetase Domain Containing 11 2 | | NS3TP11 2 3 | | NBLA000581 2 | | HCV NS3-Transactivated Protein 12 3 | | FLJ207521 | | Asparagine Synthetase Domain-Containing Protein 12 |
Export aliases for ASNSD1 gene to outside databasesPrevious GC identifers: GC02P190234 GC02P182385 |
Summaries
for ASNSD1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ASNSD1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ASNSD1 gene promoter:
MEF-2 Brachyury HSF1 (long) MEF-2A COMP1 HSF1short Cart-1 aMEF-2 RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for ASNSD1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASNSD1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p24.3-q21.3 Ensembl cytogenetic band: 2q32.2 HGNC cytogenetic band: 2q32.2ASNSD1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P190526: view genomic region
(about GC identifiers)
Start:
|
190,526,125 bp from pter |
End:
|
190,535,557 bp from pter |
Size:
|
9,433 bases |
Orientation:
|
plus strand |
|
Proteins
for ASNSD1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ASND1_HUMAN, Q9NWL6 (See
protein sequence)Recommended Name: Asparagine synthetase domain-containing protein 1 Size: 643 amino acids; 72080 Da
Secondary accessions: D3DPH6 Q3LIC3 Q4ZG45Explore the universe of human proteins at neXtProt for ASNSD1: NX_Q9NWL6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NWL6
ASNSD1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_061921.1
ENSEMBL proteins: ENSP00000260952 ENSP00000398129 ENSP00000406790
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
ASNSD1 for ontologies About GeneDecksing
ASNSD1 Antibody Products:
Assay Products for ASNSD1: |
Protein
Domains /
Families
for ASNSD1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ASNSD1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NWL6ProtoNet protein and cluster: Q9NWL6 UniProtKB/Swiss-Prot: ASND1_HUMAN, Q9NWL6Similarity: Contains 1 asparagine synthetase domainSimilarity: Contains 1 glutamine amidotransferase type-2 domain |
Function
for ASNSD1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASNSD1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASNSD1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ASNSD1 (NM_019048) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ASNSD1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASNSD1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASNSD1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- | | GO:0004066 | asparagine synthase (glutamine-hydrolyzing) activity |
IEA | -- |
ASNSD1 for ontologies About GeneDecksing
|
Pathways & Interactions
for ASNSD1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ASNSD1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for ASNSD1 (ENSP000002609524) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006529 | asparagine biosynthetic process |
IEA | -- | | GO:0006541 | glutamine metabolic process |
IEA | -- | | GO:0008150 | biological_process |
ND | -- |
ASNSD1 for ontologies About GeneDecksing
|
Drugs & Compounds
for ASNSD1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ASNSD1
Search CenterWatch for drugs/clinical trials and news about ASNSD1 / ASND1
|
Transcripts
for ASNSD1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ASNSD1 gene: NM_019048.2 Unigene Cluster for ASNSD1: Asparagine synthetase domain containing 1 Hs.101364 [show with all ESTs]Unigene Representative Sequence: NM_0190483 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000260952(uc002uqt.3) ENST00000425590 ENST00000420250
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASNSD1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASNSD1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ASNSD1 (NM_019048) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ASNSD1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASNSD1 |
Additional cDNA sequence: AB075481.1 AK000759.1 AY116969.1 BC001243.1 13 DOTS entries: DT.455725 DT.100790918 DT.100790913 DT.86852551 DT.120996545 DT.100790910 DT.100790909 DT.40120077 DT.101955390 DT.86852550 DT.100790912 DT.120996556 DT.95278109 24/274 AceView cDNA sequences (see all 274): CR594310 AV706244 F11018 CR621025 AL578731 CR621606 T30561 CB163773 BI712528 BX107229 AI879983 BG031674 BM918758 CR594492 BM802677 AI815682 BM713603 BM801530 AI720921 BQ421158 BM766987 BM670756 AA970486 BM840284
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ASNSD1 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ASNSD1
|
Expression
for ASNSD1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ASNSD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCTTAGAAA
About this image
See ASNSD1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ASNSD1
SOURCE GeneReport for Unigene cluster: Hs.101364
SABiosciences Custom PCR Arrays for ASNSD1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ASNSD1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ASNSD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ASNSD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASNSD1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASNSD1 |
Orthologs
for ASNSD1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ASNSD1 gene from 10/34 species (see all 34) About this table
ENSEMBL Gene Tree for ASNSD1 (if available)
TreeFam Gene Tree for ASNSD1 (if available) |
Paralogs
for ASNSD1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for ASNSD1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ASNSD1 (190526125 - 190535557 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ASNSD1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ASNSD1 |
|
Disorders
/ Diseases
for ASNSD1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ASNSD1 for disorders About GeneDecksing
3  diseases for ASNSD1: About MalaCardsloeys-dietz syndrome ehlers-danlos syndrome neuroblastoma
1 disease from the University of Copenhagen DISEASES database for ASNSD1:Loeys-Dietz syndrome Export disorders for ASNSD1 gene to outside databases
|
Publications
for ASNSD1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ASNSD1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ASNSD1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Construction of eukaryotic expression plasmid containing HCV NS3 segment and protein expression in human HL-7702 hepatocytes. (PubMed id 16534843)1 Li J.W....Huang Z.Q. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma. (PubMed id 12880961)2 Ohira M.... Nakagawara A. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for ASNSD1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ASNSD1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ASNSD1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ASNSD1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ASNSD1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ASNSD1 gene:
Search GeneIP for patents involving ASNSD1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ASNSD1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ASNSD1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ASNSD1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ASNSD1 | | | OriGene Protein Over-expression Lysate for ASNSD1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ASNSD1 | | OriGene 3'-UTR Clone for ASNSD1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASNSD1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASNSD1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ASNSD1 | | OriGene Custom Protein Services for ASNSD1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ASNSD1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ASNSD1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASNSD1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ASNSD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASNSD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ASNSD1 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for ASNSD1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | ASNSD1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASNSD1 |
|  |  |  | | | | ThermoFisher Antibodies for ASNSD1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASNSD1 |
|
|
|
|
