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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ASNS Gene

protein-coding   GIFtS: 66
GCID: GC07M097481

Asparagine Synthetase (Glutamine-Hydrolyzing)

(Previous name: asparagine synthetase)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Asparagine Synthetase (Glutamine-Hydrolyzing)1 2     Asparagine Synthetase1
Glutamine-Dependent Asparagine Synthetase2 3     Asparagine Synthetase [Glutamine-Hydrolyzing]2
TS112 3     TS11 Cell Cycle Control Protein2
EC 6.3.5.43 8     Cell Cycle Control Protein TS113

External Ids:    HGNC: 7531   Entrez Gene: 4402   Ensembl: ENSG000000706697   OMIM: 1083705   UniProtKB: P082433   

Export aliases for ASNS gene to outside databases

Previous GC identifers: GC07M096016 GC07M097079 GC07M097093 GC07M097126 GC07M097319 GC07M092082


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ASNS Gene:
The protein encoded by this gene is involved in the synthesis of asparagine. This gene complements a mutation in
the temperature-sensitive hamster mutant ts11, which blocks progression through the G1 phase of the cell cycle at
nonpermissive temperature. Alternatively spliced transcript variants have been described for this gene. (provided
by RefSeq, May 2010)

GeneCards Summary for ASNS Gene: 
ASNS (asparagine synthetase (glutamine-hydrolyzing)) is a protein-coding gene. Diseases associated with ASNS include lymphoblastic leukemia, and acute lymphocytic leukemia, and among its related super-pathways are Metabolic pathways and citrulline biosynthesis. GO annotations related to this gene include asparagine synthase (glutamine-hydrolyzing) activity and protein homodimerization activity.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ASNS gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ASNS promoter sequence
   Search SABiosciences Chromatin IP Primers for ASNS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASNS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.3   Ensembl cytogenetic band:  7q21.3   HGNC cytogenetic band: 7q21.3

ASNS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASNS gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M097481:  view genomic region     (about GC identifiers)

Start:
97,481,429 bp from pter      End:
97,501,854 bp from pter
Size:
20,426 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 96,803,932-96,824,039     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ASNS_HUMAN, P08243 (See protein sequence)
Recommended Name: Asparagine synthetase [glutamine-hydrolyzing]  
Size: 561 amino acids; 64370 Da
Secondary accessions: A4D1I8 B4DXZ1 B7ZAA9 D6W5R3 E9PCI3 E9PCX6 P08184 Q15666 Q549T9 Q96HD0
Alternative splicing: 3 isoforms:  P08243-1   P08243-2   P08243-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ASNS: NX_P08243

Explore proteomics data for ASNS at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P08243

  • 4/18 DME Specific Peptides for ASNS (P08243) (see all 18)
     FEFEYQT  SGEGSDE  SYYLSLP  NGEIYNH 

    ASNS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ASNS Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001171546.1  NP_001171547.1  NP_001171548.1  NP_001664.3  NP_597680.2  NP_899199.2  

    ENSEMBL proteins: 
     ENSP00000377846   ENSP00000401651   ENSP00000414379   ENSP00000377845   ENSP00000414901  
     ENSP00000408472   ENSP00000406994   ENSP00000400422   ENSP00000394242   ENSP00000402350  
     ENSP00000408797   ENSP00000397802   ENSP00000413797   ENSP00000175506  
    Reactome Protein details: P08243
    Human Recombinant Protein Products for ASNS: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for ASNS
    OriGene Protein Over-expression Lysate for ASNS
    OriGene MassSpec for ASNS 
    OriGene Custom Protein Services for ASNS
    GenScript Custom Purified and Recombinant Proteins Services for ASNS
    Novus Biologicals ASNS Proteins
    Novus Biologicals ASNS Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ASNS 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    ASNS for ontologies           About GeneDecksing



    ASNS Antibody Products: 
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    Novus Biologicals ASNS Antibodies
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    LSBio Antibodies in human, mouse, rat for ASNS 

    Assay Products for ASNS: 
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ASNS 
    Cloud-Clone Corp. CLIAs for ASNS


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR000583 GATase_dom
     IPR006426 Asn_synth_AEB
     IPR014729 Rossmann-like_a/b/a_fold
     IPR001962 Asn_synthase
     IPR017932 GATase_2_dom

    Graphical View of Domain Structure for InterPro Entry P08243

    ProtoNet protein and cluster: P08243

    1 Blocks protein domain: IPB001962 Asparagine synthase

    UniProtKB/Swiss-Prot: ASNS_HUMAN, P08243
    Similarity: Contains 1 asparagine synthetase domain
    Similarity: Contains 1 glutamine amidotransferase type-2 domain


    ASNS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ASNS_HUMAN, P08243
    Catalytic activity: ATP + L-aspartate + L-glutamine + H(2)O = AMP + diphosphate + L-asparagine + L-glutamate

         Genatlas biochemistry entry for ASNS:
    asparagine synthetase

         Enzyme Number (IUBMB): EC 6.3.5.41 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004066asparagine synthase (glutamine-hydrolyzing) activity IDA16023613
    GO:0005524ATP binding IEA--
    GO:0042803protein homodimerization activity IEA--
    GO:0048037cofactor binding IEA--
         
    ASNS for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ASNS:
     Decreased Salmonella enterica  

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Asns):
     cardiovascular system  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     pigmentation  vision/eye 

    ASNS for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ASNS 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ASNS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ASNS 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ASNS 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ASNS
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ASNS
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ASNS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ASNS

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ASNS
    Sirion Biotech Customized adenovirus for overexpression of ASNS

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ASNS (see all 28)
    OriGene ORF clones in mouse, rat for ASNS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): ASNS (NM_183356)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ASNS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASNS
    Sirion Biotech Customized lentivirus for stable overexpression of ASNS 
                         Customized lentivirus expression plasmids for stable overexpression of ASNS 

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASNS


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ASNS About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    2glutamine degradation I
    superpathway of citrulline metabolism0.50
    glutamine degradation I0.43
    citrulline biosynthesis0.50
    asparagine biosynthesis I0.33
    3Activation of Genes by ATF4
    Activation of Genes by ATF40.64
    PERK regulated gene expression0.64
    4Activation of Chaperone Genes by XBP1(S)
    Unfolded Protein Response0.76
    5Asparagine N-linked glycosylation
    Metabolism of proteins0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 BioSystems Pathways for ASNS
        citrulline biosynthesis
    superpathway of citrulline metabolism
    asparagine biosynthesis I
    glutamine degradation I

    5/7        Reactome Pathways for ASNS (see all 7)
        Metabolism
    PERK regulated gene expression
    Metabolism of proteins
    Amino acid synthesis and interconversion (transamination)
    Metabolism of amino acids and derivatives


    2         Kegg Pathways  (Kegg details for ASNS):
        Alanine, aspartate and glutamate metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: ASNS_HUMAN, P08243
    Pathway: Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (L-Gln route): step 1/1


    ASNS for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ASNS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/61 Interacting proteins for ASNS (P082432, 3 ENSP000001755064) via UniProtKB, MINT, STRING, and/or I2D (see all 61)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    STRN4Q9NRL32, 3MINT-65600 I2D: score=5 
    CTPS1P178123, ENSP000003616994I2D: score=2 STRING: ENSP00000361699
    UBCP0CG483, ENSP000003448184I2D: score=2 STRING: ENSP00000344818
    IKBKEQ141643, ENSP000003560874I2D: score=1 STRING: ENSP00000356087
    PRKAG2Q9UGJ03, ENSP000002878784I2D: score=2 STRING: ENSP00000287878
    About this table

    Gene Ontology (GO): 5/23 biological process terms (GO ID links to tree view) (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001889liver development IEA--
    GO:0006520cellular amino acid metabolic process ----
    GO:0006529asparagine biosynthetic process IDA2573597
    GO:0006541glutamine metabolic process IEA--
    GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--

    ASNS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ASNS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ASNS

    10 HMDB Compounds for ASNS    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    FamotidineAmfamox (see all 83)76824-35-6--
    L-Asparagine(-)-Asparagine (see all 32)70-47-3--
    L-Aspartic acid(+)-Aspartate (see all 41)56-84-8--
    L-Glutamic acid(2S)-2-Aminopentanedioate (see all 49)56-86-0--
    L-Glutamine(2S)-2,5-diamino-5-oxopentanoic acid (see all 31)56-85-9--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    5 DrugBank Compounds for ASNS    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Asparagine(-)-Asparagine (see all 15)70-47-3target--14990305 17380207 12706338 15574844 16164412
    L-Glutamine(S)-2,5-diamino-5-oxopentanoic acid (see all 4)56-85-9enzymesubstrate16931516 16164412 17329242 16870293 17397190
    Adenosine triphosphate5'-ATP (see all 8)56-65-5target--17139284 17016423
    L-Aspartic Acid(+)-Aspartic acid (see all 23)56-84-8target--17139284 17016423
    L-Glutamic Acid(2S)-2-Aminopentanedioic acid (see all 15)56-86-0target--17139284 17016423

    10/13 Novoseek inferred chemical compound relationships for ASNS gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    asparagine 94.6 187 16164412 (5), 1359839 (4), 16923354 (4), 1358303 (4) (see all 97)
    albizziin 90.3 3 8105542 (2)
    amino acid 69.8 11 11677247 (1), 12628003 (1), 10856289 (1), 18840095 (1) (see all 6)
    glutamine 57.4 10 1359839 (3), 8102140 (3), 12805577 (1), 11551215 (1) (see all 6)
    carbamoyl phosphate 43.5 2 11395405 (1), 12859215 (1)
    aspartate 37.9 3 16164412 (1), 8102140 (1), 11551215 (1)
    amide 30.4 2 8102140 (1), 12890666 (1)
    glutamate 18.6 3 15385533 (1), 12859215 (1)
    glucose 14.3 5 11677247 (1), 12628003 (1), 12881527 (1), 17409444 (1)
    histidine 1.06 1 10948265 (1)

    Search CenterWatch for drugs/clinical trials and news about ASNS

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ASNS gene (6 alternative transcripts): 
    NM_001178075.1  NM_001178076.1  NM_001178077.1  NM_001673.4  NM_133436.3  NM_183356.3  

    Unigene Cluster for ASNS:

    Asparagine synthetase (glutamine-hydrolyzing)
    Hs.489207  [show with all ESTs]
    Unigene Representative Sequence: NM_183356
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394309(uc003uot.4 uc011kin.2) ENST00000454046 ENST00000437628
    ENST00000394308 ENST00000422745 ENST00000455086 ENST00000444334 ENST00000487714
    ENST00000462436 ENST00000442734 ENST00000495255 ENST00000437657 ENST00000448127
    ENST00000453600 ENST00000451771 ENST00000414884 ENST00000175506(uc011kio.2 uc003uou.4 uc003uov.4 uc003uox.4)

    miRNA
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    GenScript: all cDNA clones in your preferred vector (see all 6): ASNS (NM_183356)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASNS
    Sirion Biotech Customized lentivirus for stable overexpression of ASNS 
                         Customized lentivirus expression plasmids for stable overexpression of ASNS 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ASNS
    OriGene qSTAR qPCR primer pairs in human, mouse for ASNS
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ASNS
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASNS

    Additional mRNA sequence: 

    AK000379.1 AK302189.1 AK302242.1 AK316224.1 BC008723.2 BC014621.2 BT007113.1 M15798.1 
    M27396.1 

    24/27 DOTS entries (see all 27):

    DT.92457837  DT.452523  DT.100877448  DT.100877477  DT.99982693  DT.121050523  DT.100839795  DT.92457840 
    DT.97821209  DT.121050297  DT.99948035  DT.100030257  DT.95262520  DT.75125009  DT.95262541  DT.95262517 
    DT.101981674  DT.91894956  DT.100877476  DT.100877480  DT.100877482  DT.101958426  DT.121050382  DT.436578 

    24/637 AceView cDNA sequences (see all 637):

    BQ049138 BU178677 BU675019 BI752279 CA447695 BU190621 BQ000664 BT007113 
    BG118510 AI278536 AA362376 CR600992 BQ049076 BU169447 AI632334 AU099152 
    CA446777 CB134584 BQ678047 BM909400 BI254975 BU688320 BQ448630 AL559639 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ASNS (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b
    SP1:                                                                                                              -     -                                 
    SP2:                          -     -     -                                                                                                               
    SP3:                          -     -     -     -     -                                                                                                   
    SP4:                                                                                                                                                      
    SP5:                          -     -                                                                                                                     


    ECgene alternative splicing isoforms for ASNS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ASNS expression in normal human tissues (normalized intensities)      ASNS embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCTTGAACT
    ASNS Expression
    About this image


    ASNS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/21 selected tissues (see all 21) fully expand
     
     Brain (Nervous System)    fully expand to see all 12 entries
             Cerebral Cortex
             ganglion/cranial/facial VII   
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Floor Plate Cells Spinal Floor Plate
             Metencephalon
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
             Human Urothelial Cells (HUC)   
             visceral organ   
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Mature Horizontal Cells Inner Nuclear Layer
             Retina
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Cardiac Fibroblasts Myocardium
             Cardiac Myocytes   

    See ASNS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ASNS

    SOURCE GeneReport for Unigene cluster: Hs.489207
        SABiosciences Expression via Pathway-Focused PCR Arrays including ASNS: 
              Amino Acid Metabolism II in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ASNS gene from 10/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Asns1 , 5 asparagine synthetase1, 5 87.76(n)1
    93.94(a)1
      6 (3.31 cM)5
    270531  NM_012055.31  NP_036185.11 
     76751695 
    chicken
    (Gallus gallus)
    Aves ASNS1 asparagine synthetase (glutamine-hydrolyzing) 77.02(n)
    80.71(a)
      420574  NM_001030977.1  NP_001026148.1 
    lizard
    (Anolis carolinensis)
    Reptilia ASNS6
    Asparagine synthetase
    80(a)
    1 ↔ 1
    6(23528980-23548969)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.47832 Transcribed sequence with moderate similarity to protein more 74.96(n)    BQ390084.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc566052 similar to asparagine synthetase 75.24(n)   394138  BC052127.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta asparagine-synthetase6
    asparagine synthetase
    36(a)
    1 ↔ 1
    3L(21166218-21168073)
    worm
    (Caenorhabditis elegans)
    Secernentea nrs-23
    asns-11
    asparagine synthetase3
    Protein ASNS-11
    36(a)3
    50.92(n)1
    40.45(a)1
      V(8548883-8551113)3
    1849351  NM_072803.21  NP_505204.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ASN2(YGR124W)4 Asparagine synthetase, isozyme of Asn1p; catalyzes more   --   7(739944-741662) 853025  NP_011640.1 
    soybean
    (Glycine max)
    eudicotyledons 445181372   -- 75.16(n)  
    rice
    (Oryza sativa)
    Liliopsida Os.1352 Oryza sativa (japonica cultivar-group) mRNA for asparagine more 75.45(n)    AK100247.1 


    ENSEMBL Gene Tree for ASNS (if available)
    TreeFam Gene Tree for ASNS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ASNS gene

    ASNS for paralogs           About GeneDecksing


    5/13 Pseudogenes.org Pseudogenes for ASNS (see all 13)
    PGOHUM00000248482 PGOHUM00000234995 PGOHUM00000244189 PGOHUM00000244888 PGOHUM00000244900


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/589 SNPs in ASNS are shown (see all 589)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs78030551,2
    C,F--97480989(+) taaaaT/Cattta 6 -- ds50015Minor allele frequency- C:0.10NA EA 246
    rs766661941,2
    --97480997(+) TTACTA/CTCTGG 6 -- ds50010--------
    rs1925260671,2
    --97481016(+) TAAAAA/GCAAAT 6 -- ds50010--------
    rs1146304051,2
    C,F--97481195(+) GGCAGA/CACAAA 6 -- ds50011Minor allele frequency- C:0.08WA 118
    rs1831042871,2
    C--97481223(+) ATGACA/GTCCCT 6 -- ds50010--------
    rs756182841,2
    C,F--97481228(+) GTCCCT/AAAGAT 6 -- ds50012Minor allele frequency- A:0.05WA EA 238
    rs351903681,2
    C,F--97481248(+) ACTGGA/TAGGAA 6 -- ds50017Minor allele frequency- T:0.08NA CSA WA EA 368
    rs1874415601,2
    --97481261(+) CACACA/GGGCAC 6 -- ds50010--------
    rs751984921,2
    C,F--97481466(+) TTTTTC/AACACC 6 -- ut311Minor allele frequency- A:0.08EA 120
    rs1152702471,2
    C,F--97481491(+) TTGACT/GCTCAT 6 -- ut311Minor allele frequency- G:0.08WA 118

    HapMap Linkage Disequilibrium report for ASNS (97481429 - 97501854 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ASNS:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2672632CNV Deletion23128226
    esv2734862CNV Deletion23290073
    nsv428178CNV Gain18775914
    dgv2118e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): ASNS
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ASNS
    DNA2.0 Custom Variant and Variant Library Synthesis for ASNS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 108370    OMIM disorders: --

    17 diseases for ASNS:    About MalaCards
    lymphoblastic leukemia    acute lymphocytic leukemia    acute lymphoblastic leukemia    bipolar disorder
    non-hodgkin lymphoma    hodgkin's lymphoma    ovarian cancer    leukemia
    hypoxia    tuberculosis    pancreatic cancer    schizophrenia
    sarcoma    hepatocellular carcinoma    pancreatitis    breast cancer
    prostatitis

    1 disease from the University of Copenhagen DISEASES database for ASNS:
    Leukemia

    ASNS for disorders           About GeneDecksing

    8 Novoseek inferred disease relationships for ASNS gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoblastic leukemia acute childhood 64.5 5 16923354 (2), 15718422 (1), 16497975 (1), 19035175 (1)
    lymphoblastic leukemia acute 62.9 4 18541474 (2), 16023613 (1), 19035175 (1)
    t-all 58.7 4 16923354 (4)
    leukemia 58.5 13 17185229 (2), 11485552 (2), 1976872 (2), 18541474 (1) (see all 10)
    ovarian cancer 29.8 6 17088436 (2), 18852115 (1), 19209300 (1), 16648555 (1)
    tumors 0 3 12894236 (1), 12802930 (1), 8093451 (1)
    lymphoma 0 1 16156856 (1)
    cancer 0 1 17088436 (1)

    Human Genome Epidemiology (HuGE) Navigator: ASNS (1 document)

    Export disorders for ASNS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ASNS gene, integrated from 9 sources (see all 154):
    (articles sorted by number of sources associating them with ASNS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mesenchymal cells regulate the response of acute lymphoblastic leukemia cells to asparaginase. (PubMed id 17380207)1, 7 Iwamoto S....Campana D. (2007)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    4. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    5. Organization and expression of the cell cycle gene, ts11, that encodes asparagine synthetase. (PubMed id 2569668)1, 2 Greco A.... Basilico C. (1989)
    6. Expression of human asparagine synthetase in Escherichia coli. (PubMed id 2564390)1, 2 van Heeke G. and Schuster S.M. (1989)
    7. Molecular structure of the human asparagine synthetase gene. (PubMed id 2565875)1, 2 Zhang Y.P....Andrulis I.L. (1989)
    8. The N-terminal cysteine of human asparagine synthetase is essential for glutamine-dependent activity. (PubMed id 2573597)1, 2 van Heeke G. and Schuster S.M. (1989)
    9. Isolation of human cDNAs for asparagine synthetase and expression in Jensen rat sarcoma cells. (PubMed id 2886907)1, 2 Andrulis I.L.... Ray P.N. (1987)
    10. Molecular cloning of a gene that is necessary for G1 progression in mammalian cells. (PubMed id 3470743)1, 2 Greco A.... Basilico C. (1987)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 440 HGNC: 753 AceView: ASNS Ensembl:ENSG00000070669 euGenes: HUgn440
    ECgene: ASNS Kegg: 440 H-InvDB: ASNS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ASNS Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ASNS Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ASNS gene:
    Search GeneIP for patents involving ASNS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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