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Aliases for ASNS Gene

Aliases for ASNS Gene

  • Asparagine Synthetase (Glutamine-Hydrolyzing) 2 3
  • Glutamine-Dependent Asparagine Synthetase 3 4
  • EC 4 63
  • ASNSD 3 6
  • TS11 3 4
  • Asparagine Synthetase [Glutamine-Hydrolyzing] 3
  • TS11 Cell Cycle Control Protein 3
  • Cell Cycle Control Protein TS11 4
  • Asparagine Synthetase 2

External Ids for ASNS Gene

Previous GeneCards Identifiers for ASNS Gene

  • GC07M096016
  • GC07M097079
  • GC07M097093
  • GC07M097126
  • GC07M097319
  • GC07M097481
  • GC07M092082

Summaries for ASNS Gene

Entrez Gene Summary for ASNS Gene

  • The protein encoded by this gene is involved in the synthesis of asparagine. This gene complements a mutation in the temperature-sensitive hamster mutant ts11, which blocks progression through the G1 phase of the cell cycle at nonpermissive temperature. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]

GeneCards Summary for ASNS Gene

ASNS (Asparagine Synthetase (Glutamine-Hydrolyzing)) is a Protein Coding gene. Diseases associated with ASNS include asparagine synthetase deficiency and congenital microcephaly-severe encephalopathy-progressive cerebral atrophy syndrome. Among its related pathways are Metabolism and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include protein homodimerization activity and asparagine synthase (glutamine-hydrolyzing) activity.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASNS Gene

Genomics for ASNS Gene

Regulatory Elements for ASNS Gene

Transcription factor binding sites by QIAGEN in the ASNS gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ASNS Gene

97,852,117 bp from pter
97,872,542 bp from pter
20,426 bases
Minus strand

Genomic View for ASNS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ASNS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASNS Gene

Proteins for ASNS Gene

  • Protein details for ASNS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Asparagine synthetase [glutamine-hydrolyzing]
    Protein Accession:
    Secondary Accessions:
    • A4D1I8
    • B4DXZ1
    • B7ZAA9
    • D6W5R3
    • E9PCI3
    • E9PCX6
    • P08184
    • Q15666
    • Q549T9
    • Q96HD0

    Protein attributes for ASNS Gene

    561 amino acids
    Molecular mass:
    64370 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ASNS Gene


neXtProt entry for ASNS Gene

Proteomics data for ASNS Gene at MOPED

Post-translational modifications for ASNS Gene

  • Ubiquitination at Lys168, Lys460, Lys478, and Lys504
  • Modification sites at PhosphoSitePlus

Domains for ASNS Gene

Suggested Antigen Peptide Sequences for ASNS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 asparagine synthetase domain.
  • Contains 1 asparagine synthetase domain.
  • Contains 1 glutamine amidotransferase type-2 domain.
genes like me logo Genes that share domains with ASNS: view

No data available for Gene Families for ASNS Gene

Function for ASNS Gene

Molecular function for ASNS Gene

GENATLAS Biochemistry:
asparagine synthetase
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-aspartate + L-glutamine + H(2)O = AMP + diphosphate + L-asparagine + L-glutamate.

Enzyme Numbers (IUBMB) for ASNS Gene

Gene Ontology (GO) - Molecular Function for ASNS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity IDA 16023613
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
GO:0042803 protein homodimerization activity IEA --
GO:0048037 cofactor binding IEA --
genes like me logo Genes that share ontologies with ASNS: view
genes like me logo Genes that share phenotypes with ASNS: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ASNS

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for ASNS Gene

Localization for ASNS Gene

Subcellular locations from

Jensen Localization Image for ASNS Gene COMPARTMENTS Subcellular localization image for ASNS gene
Compartment Confidence
cytosol 4
nucleus 2
chloroplast 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ASNS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ASNS: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ASNS Gene

Pathways for ASNS Gene

genes like me logo Genes that share pathways with ASNS: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot P08243-ASNS_HUMAN

  • Pathway: Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (L-Gln route): step 1/1

Gene Ontology (GO) - Biological Process for ASNS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001889 liver development IEA --
GO:0006520 cellular amino acid metabolic process --
GO:0006529 asparagine biosynthetic process IDA 2573597
GO:0006541 glutamine metabolic process IEA --
GO:0006987 activation of signaling protein activity involved in unfolded protein response --
genes like me logo Genes that share ontologies with ASNS: view

Drugs for ASNS Gene

(5) Drugbank Compounds for ASNS Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • (2S)-2-amino-4-carbamoylbutanoic acid
56-85-9 Enzyme substrate approved, investigational, nutraceutical
Adenosine triphosphate
  • Adenosine 5'-triphosphate
56-65-5 Target approved, nutraceutical
  • (2S)-2-amino-3-carbamoylpropanoic acid
70-47-3 6267 Target approved, nutraceutical
L-Aspartic Acid
  • (S)-2-aminobutanedioic acid
56-84-8 5960 Target approved, nutraceutical
L-Glutamic Acid
  • (2S)-2-Aminopentanedioic acid
56-86-0 33032 Target nutraceutical

(10) HMDB Compounds for ASNS Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-Adenosine monophosphate
Adenosine triphosphate
  • 5'-(Tetrahydrogen triphosphate) Adenosine
  • Gastridan
  • (-)-Asparagine
L-Aspartic acid
  • Asp

(13) Novoseek inferred chemical compound relationships for ASNS Gene

Compound -log(P) Hits PubMed IDs
asparagine 94.6 157
albizziin 90.3 2
amino acid 69.8 6
glutamine 57.4 10
carbamoyl phosphate 43.5 2
genes like me logo Genes that share compounds with ASNS: view

Transcripts for ASNS Gene

Unigene Clusters for ASNS Gene

Asparagine synthetase (glutamine-hydrolyzing):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ASNS

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ASNS Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b
SP1: - -
SP2: - - -
SP3: - - - - -
SP5: - -
SP7: -
SP8: - -

Relevant External Links for ASNS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ASNS Gene

mRNA expression in normal human tissues for ASNS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for ASNS Gene

This gene is overexpressed in Breast (22.2), Stomach (11.4), and Islet of Langerhans (8.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ASNS Gene

SOURCE GeneReport for Unigene cluster for ASNS Gene Hs.489207

genes like me logo Genes that share expressions with ASNS: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for ASNS Gene

Orthologs for ASNS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ASNS Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ASNS 35
  • 91.09 (n)
  • 94.65 (a)
  • 95 (a)
(Canis familiaris)
Mammalia LOC475240 35
  • 91.8 (n)
  • 95.19 (a)
  • 95 (a)
(Mus musculus)
Mammalia Asns 35
  • 87.76 (n)
  • 93.94 (a)
Asns 16
Asns 36
  • 94 (a)
(Pan troglodytes)
Mammalia ASNS 35
  • 99.58 (n)
  • 99.82 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Asns 35
  • 88 (n)
  • 93.58 (a)
(Ornithorhynchus anatinus)
Mammalia ASNS 36
  • 54 (a)
(Gallus gallus)
Aves ASNS 35
  • 77.02 (n)
  • 80.71 (a)
  • 81 (a)
(Anolis carolinensis)
Reptilia ASNS 36
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia asns 35
  • 73.43 (n)
  • 79.49 (a)
Str.4783 35
(Danio rerio)
Actinopterygii asns 35
  • 68.83 (n)
  • 72.25 (a)
zgc56605 35
asns 36
  • 71 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9138 35
fruit fly
(Drosophila melanogaster)
Insecta asparagine-synthetase 36
  • 37 (a)
(Caenorhabditis elegans)
Secernentea nrs-2 37
  • 36 (a)
asns-1 35
  • 51.06 (n)
  • 40.25 (a)
asns-1 36
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ASN1 36
  • 36 (a)
ASN2 36
  • 37 (a)
ASN2 38
(Oryza sativa)
Liliopsida Os.135 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14999 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
-- 36
  • 51 (a)
-- 36
  • 51 (a)
Species with no ortholog for ASNS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ASNS Gene

Gene Tree for ASNS (if available)
Gene Tree for ASNS (if available)

Paralogs for ASNS Gene

genes like me logo Genes that share paralogs with ASNS: view

No data available for Paralogs for ASNS Gene

Variants for ASNS Gene

Sequence variations from dbSNP and Humsavar for ASNS Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1017070 -- 97,860,118(-) TTCAG(C/T)GCTAC intron-variant
rs1049674 - 97,859,257(-) GGATG(A/T)ACCCC missense, reference
rs1049677 -- 97,854,609(-) GTTCT(C/G)CGCGC reference, synonymous-codon
rs1803163 -- 97,852,305(-) TGACC(A/C)TTCTG missense, reference
rs1974562 -- 97,873,425(-) TGTTG(A/G)CGTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ASNS Gene

Variant ID Type Subtype PubMed ID
nsv428178 CNV Gain 18775914
dgv2118e1 CNV Complex 17122850
esv2734862 CNV Deletion 23290073
esv2672632 CNV Deletion 23128226

Relevant External Links for ASNS Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASNS Gene

Disorders for ASNS Gene

(1) OMIM Diseases for ASNS Gene (108370)


  • Asparagine synthetase deficiency (ASNSD) [MIM:615574]: An inborn error of asparagine biosynthesis that results in a severe neurologic disorder characterized by microcephaly, severely delayed psychomotor development, progressive encephalopathy, cortical atrophy, and seizure or hyperekplexic activity. {ECO:0000269 PubMed:24139043}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for ASNS Gene

(8) Novoseek inferred disease relationships for ASNS Gene

Disease -log(P) Hits PubMed IDs
lymphoblastic leukemia acute childhood 64.5 5
lymphoblastic leukemia acute 62.9 4
t-all 58.7 4
leukemia 58.5 13
ovarian cancer 29.8 5

Relevant External Links for ASNS

Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ASNS: view

No data available for Genatlas for ASNS Gene

Publications for ASNS Gene

  1. Regulation of asparagine synthetase gene transcription by the basic region leucine zipper transcription factors ATF5 and CHOP. (PMID: 16164412) Al Sarraj J. … Thiel G. (Biol. Chem. 2005) 23 25 26
  2. Differences in the molecular mechanisms involved in the transcriptional activation of the CHOP and asparagine synthetase genes in response to amino acid deprivation or activation of the unfolded protein response. (PMID: 12351626) Bruhat A. … Fafournoux P. (J. Biol. Chem. 2002) 3 23
  3. [Study of the correlation between the expression level of asparagine synthetase and the outcome of children with acute lymphocytic leukemia]. (PMID: 19035175) Luo C.Y. … Gu L.J. (Zhonghua Xue Ye Xue Za Zhi 2008) 3 23
  4. Molecular structure of the human asparagine synthetase gene. (PMID: 2565875) Zhang Y.P. … Andrulis I.L. (Genomics 1989) 3 4
  5. Molecular cloning of a gene that is necessary for G1 progression in mammalian cells. (PMID: 3470743) Greco A. … Basilico C. (Proc. Natl. Acad. Sci. U.S.A. 1987) 3 4

Products for ASNS Gene

Sources for ASNS Gene

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