Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ASNA1 Gene

Aliases for ASNA1 Gene

  • ArsA Arsenite Transporter, ATP-Binding, Homolog 1 (Bacterial) 2 3
  • Transmembrane Domain Recognition Complex 40 KDa ATPase Subunit 3 4
  • HASNA-I 3 4
  • ARSA1 3 6
  • TRC40 3 4
  • ArsA (Bacterial) Arsenite Transporter, ATP-Binding, Homolog 1 2
  • Transmembrane Domain Recognition Complex, 40kDa 3
  • Golgi To ER Traffic 3 Homolog (S. Cerevisiae) 2
  • Transmembrane Domain Recognition Complex 2
  • Golgi To ER Traffic 3 Homolog 3
  • Arsenical Pump-Driving ATPase 4
  • Arsenite-Stimulated ATPase 4
  • ATPase ASNA1 3
  • EC 3.6.3.16 63
  • EC 3.6.-.- 4
  • HARSA-I 4
  • ARSA-I 3
  • ASNA-I 3
  • 40kDa 2
  • GET3 3
  • ARSA 4

External Ids for ASNA1 Gene

Previous GeneCards Identifiers for ASNA1 Gene

  • GC19P012979
  • GC19P013071
  • GC19P012693
  • GC19P012848
  • GC19P012421

Summaries for ASNA1 Gene

Entrez Gene Summary for ASNA1 Gene

  • This gene represents the human homolog of the bacterial arsA gene, encoding the arsenite-stimulated ATPase component of the arsenite transporter responsible for resistance to arsenicals. This protein is also a central component of a transmembrane domain (TMD) recognition complex (TRC) that is involved in the post-translational delivery of tail-anchored (TA) proteins from the cytosol to the endoplasmic reticulum (ER). It recognizes and selectively binds the TMD of TA proteins in the cytosol, and delivers them to the ER for insertion. [provided by RefSeq, Oct 2011]

GeneCards Summary for ASNA1 Gene

ASNA1 (ArsA Arsenite Transporter, ATP-Binding, Homolog 1 (Bacterial)) is a Protein Coding gene. Diseases associated with ASNA1 include breast adenoma. Among its related pathways are PTM- gamma carboxylation, hypusine formation and arylsulfatase activation and PTM- gamma carboxylation, hypusine formation and arylsulfatase activation. GO annotations related to this gene include transporter activity and arsenite transmembrane transporter activity.

UniProtKB/Swiss-Prot for ASNA1 Gene

  • ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting (By similarity). May be involved in insulin signaling.

Gene Wiki entry for ASNA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASNA1 Gene

Genomics for ASNA1 Gene

Regulatory Elements for ASNA1 Gene

Genomic Location for ASNA1 Gene

Start:
12,737,139 bp from pter
End:
12,748,323 bp from pter
Size:
11,185 bases
Orientation:
Plus strand

Genomic View for ASNA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ASNA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASNA1 Gene

Proteins for ASNA1 Gene

  • Protein details for ASNA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43681-ASNA_HUMAN
    Recommended name:
    ATPase ASNA1
    Protein Accession:
    O43681
    Secondary Accessions:
    • A6NHP8
    • A8K740
    • Q53FC6
    • Q92849

    Protein attributes for ASNA1 Gene

    Size:
    348 amino acids
    Molecular mass:
    38793 Da
    Quaternary structure:
    • Homodimer (By similarity). Component of a transmembrane domain recognition complex (TRC) (By similarity). Interacts with SERP1 and SEC61B (By similarity). Interacts with WRB.
    SequenceCaution:
    • Sequence=AAC50731.1; Type=Frameshift; Positions=19; Evidence={ECO:0000305};

neXtProt entry for ASNA1 Gene

Proteomics data for ASNA1 Gene at MOPED

Post-translational modifications for ASNA1 Gene

  • Ubiquitination at Lys156 and Lys317
  • Modification sites at PhosphoSitePlus

Other Protein References for ASNA1 Gene

Domains for ASNA1 Gene

Suggested Antigen Peptide Sequences for ASNA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43681

UniProtKB/Swiss-Prot:

ASNA_HUMAN :
  • O43681
Family:
  • Belongs to the arsA ATPase family.
genes like me logo Genes that share domains with ASNA1: view

No data available for Gene Families for ASNA1 Gene

Function for ASNA1 Gene

Molecular function for ASNA1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=0.22 mM for ATP {ECO:0000269 PubMed:9712828}; Vmax=16.6 nmol/min/mg enzyme for ATP {ECO:0000269 PubMed:9712828};
UniProtKB/Swiss-Prot Function: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting (By similarity). May be involved in insulin signaling.

Enzyme Numbers (IUBMB) for ASNA1 Gene

Gene Ontology (GO) - Molecular Function for ASNA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity TAS 9736449
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
GO:0015105 arsenite transmembrane transporter activity TAS 8884272
GO:0016887 ATPase activity IEA --
genes like me logo Genes that share ontologies with ASNA1: view

Phenotypes for ASNA1 Gene

MGI mutant phenotypes for ASNA1:
inferred from 1 alleles
GenomeRNAi human phenotypes for ASNA1:
genes like me logo Genes that share phenotypes with ASNA1: view

Animal Models for ASNA1 Gene

MGI Knock Outs for ASNA1:

miRNA for ASNA1 Gene

miRTarBase miRNAs that target ASNA1

No data available for Transcription Factor Targeting and HOMER Transcription for ASNA1 Gene

Localization for ASNA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ASNA1 Gene

Cytoplasm. Endoplasmic reticulum. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ASNA1 Gene COMPARTMENTS Subcellular localization image for ASNA1 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 5
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for ASNA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm TAS 9736449
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with ASNA1: view

Pathways for ASNA1 Gene

genes like me logo Genes that share pathways with ASNA1: view

Gene Ontology (GO) - Biological Process for ASNA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006810 transport TAS 9736449
GO:0015698 inorganic anion transport TAS 8884272
GO:0030968 endoplasmic reticulum unfolded protein response TAS --
GO:0036498 IRE1-mediated unfolded protein response TAS --
genes like me logo Genes that share ontologies with ASNA1: view

Compounds for ASNA1 Gene

(2) HMDB Compounds for ASNA1 Gene

Compound Synonyms Cas Number PubMed IDs
Arsenic
  • As
7440-38-2
Arsenite
  • AArsenite (AsO33-)
15502-74-6

(1) Drugbank Compounds for ASNA1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Adenosine triphosphate
  • 5'-ATP
56-65-5 target

(4) Novoseek inferred chemical compound relationships for ASNA1 Gene

Compound -log(P) Hits PubMed IDs
antimonite 96.7 7
arsenite 85.4 7
arsenate 82.5 2
atp 27.3 4
genes like me logo Genes that share compounds with ASNA1: view

Transcripts for ASNA1 Gene

Unigene Clusters for ASNA1 Gene

ArsA arsenite transporter, ATP-binding, homolog 1 (bacterial):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ASNA1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
SP1:
SP2:
SP3: -

Relevant External Links for ASNA1 Gene

GeneLoc Exon Structure for
ASNA1
ECgene alternative splicing isoforms for
ASNA1

Expression for ASNA1 Gene

mRNA expression in normal human tissues for ASNA1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ASNA1 Gene

SOURCE GeneReport for Unigene cluster for ASNA1 Gene Hs.465985

mRNA Expression by UniProt/SwissProt for ASNA1 Gene

O43681-ASNA_HUMAN
Tissue specificity: Expressed in the epithelial cells of the liver, kidney, and stomach wall, in the adrenal medulla, in the islet cells of the pancreas, in the red pulp of the spleen, and in cardiac and skeletal muscle.
genes like me logo Genes that share expressions with ASNA1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ASNA1 Gene

Orthologs for ASNA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ASNA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ASNA1 35
  • 99.55 (n)
  • 100 (a)
ASNA1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ASNA1 35
  • 92.15 (n)
  • 100 (a)
ASNA1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 94 (a)
OneToMany
-- 36
  • 100 (a)
OneToMany
ASNA1 35
  • 93.01 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Asna1 35
  • 90.52 (n)
  • 99.71 (a)
Asna1 16
Asna1 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ASNA1 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ASNA1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Asna1 35
  • 90.13 (n)
  • 99.71 (a)
chicken
(Gallus gallus)
Aves ASNA1 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ASNA1 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia asna1 35
  • 80.65 (n)
  • 89.58 (a)
Str.11846 35
zebrafish
(Danio rerio)
Actinopterygii asna1 35
  • 82.68 (n)
  • 96.1 (a)
asna1 36
  • 95 (a)
OneToOne
zgc56540 35
African malaria mosquito
(Anopheles gambiae)
Insecta ASNA_ANOGA 35
  • 68.82 (n)
  • 70.46 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1598 35
  • 70.64 (n)
  • 69.11 (a)
CG1598 36
  • 67 (a)
OneToOne
CG1598 37
  • 68 (a)
worm
(Caenorhabditis elegans)
Secernentea asna-1 35
  • 56.35 (n)
  • 56.56 (a)
asna-1 36
  • 53 (a)
OneToMany
asna-2 36
  • 32 (a)
OneToMany
ZK637.5 37
  • 54 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR285W 35
  • 55.83 (n)
  • 50.31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GET3 35
  • 51.96 (n)
  • 50.48 (a)
GET3 36
  • 44 (a)
OneToOne
GET3 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E01497g 35
  • 51.76 (n)
  • 49.84 (a)
soybean
(Glycine max)
eudicotyledons Gma.10970 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G01910 35
  • 56.86 (n)
  • 55.7 (a)
corn
(Zea mays)
Liliopsida Zm.5442 35
rice
(Oryza sativa)
Liliopsida Os.15713 35
Os09g0521500 35
  • 57.71 (n)
  • 56.96 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06717 35
  • 59.82 (n)
  • 54.6 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes get3 35
  • 54.52 (n)
  • 56.7 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8413 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 63 (a)
OneToOne
Species with no ortholog for ASNA1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ASNA1 Gene

ENSEMBL:
Gene Tree for ASNA1 (if available)
TreeFam:
Gene Tree for ASNA1 (if available)

Paralogs for ASNA1 Gene

Pseudogenes.org Pseudogenes for ASNA1 Gene

genes like me logo Genes that share paralogs with ASNA1: view

No data available for Paralogs for ASNA1 Gene

Variants for ASNA1 Gene

Sequence variations from dbSNP and Humsavar for ASNA1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs750796 -- 12,748,445(+) gatgc(A/G)tgttt downstream-variant-500B
rs896388 -- 12,739,152(+) GGGGA(A/G)AAGTA intron-variant
rs1802249 -- 12,747,547(+) TGCAA(A/G)ATGTG synonymous-codon, reference
rs1802250 -- 12,748,145(+) TCACC(C/T)TCCAC utr-variant-3-prime
rs1802251 -- 12,748,284(+) TACCT(A/C)TCCCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ASNA1 Gene

Variant ID Type Subtype PubMed ID
dgv3733n71 CNV Loss 21882294
nsv911077 CNV Loss 21882294

Relevant External Links for ASNA1 Gene

HapMap Linkage Disequilibrium report
ASNA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASNA1 Gene

Disorders for ASNA1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ASNA1 Gene including...

Search for ASNA1 Gene in MalaCards »

Relevant External Links for ASNA1

Genetic Association Database (GAD)
ASNA1
genes like me logo Genes that share disorders with ASNA1: view

No data available for UniProtKB/Swiss-Prot for ASNA1 Gene

Publications for ASNA1 Gene

  1. Isolation of the ATP-binding human homolog of the arsA component of the bacterial arsenite transporter. (PMID: 8884272) Kurdi-Haidar B. … Howell S.B. (Genomics 1996) 2 3 4 23
  2. Biochemical characterization of the human arsenite-stimulated ATPase (hASNA-I). (PMID: 9712828) Kurdi-Haidar B. … Howell S.B. (J. Biol. Chem. 1998) 3 4 23
  3. Identification of a targeting factor for posttranslational membrane protein insertion into the ER. (PMID: 17382883) Stefanovic S. … Hegde R.S. (Cell 2007) 2 3 4
  4. ASNA-1 positively regulates insulin secretion in C. elegans and mammalian cells. (PMID: 17289575) Kao G. … Naredi P. (Cell 2007) 3 23
  5. Increased sensitivity to platinating agents and arsenite in human ovarian cancer by downregulation of ASNA1. (PMID: 19724867) Hemmingsson O. … Naredi P. (Oncol. Rep. 2009) 3 23

Products for ASNA1 Gene

Sources for ASNA1 Gene

Back to Top

Content