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ASNA1 Gene

protein-coding   GIFtS: 61
GCID: GC19P012848

ArsA Arsenite Transporter, ATP-Binding, Homolog 1 (Bacterial)

(Previous names: arsA (bacterial) arsenite transporter, ATP-binding, homolog...)
  See ASNA1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ArsA Arsenite Transporter, ATP-Binding, Homolog 1 (Bacterial)1 2     ARSA-I2
Arsenical Pump-Driving ATPase2 3     ASNA-I2
Arsenite-Stimulated ATPase2 3     GET32
Transmembrane Domain Recognition Complex 40 KDa ATPase Subunit2 3     ATPase ASNA12
TRC402 3     Golgi To ER Traffic 3 Homolog2
hASNA-I2 3     Transmembrane Domain Recognition Complex, 40kDa2
ARSA12 5     ARSA3
40kDa1     EC 3.6.-.-3
ArsA (Bacterial) Arsenite Transporter, ATP-Binding, Homolog 11     hARSA-I3
Golgi To ER Traffic 3 Homolog (S. Cerevisiae)1     EC 3.6.3.168
Transmembrane Domain Recognition Complex1     

External Ids:    HGNC: 7521   Entrez Gene: 4392   Ensembl: ENSG000001983567   OMIM: 6019135   UniProtKB: O436813   

Export aliases for ASNA1 gene to outside databases

Previous GC identifers: GC19P012979 GC19P013071 GC19P012693 GC19P012709 GC19P012421


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ASNA1 Gene:
This gene represents the human homolog of the bacterial arsA gene, encoding the arsenite-stimulated ATPase
component of the arsenite transporter responsible for resistance to arsenicals. This protein is also a central
component of a transmembrane domain (TMD) recognition complex (TRC) that is involved in the post-translational
delivery of tail-anchored (TA) proteins from the cytosol to the endoplasmic reticulum (ER). It recognizes and
selectively binds the TMD of TA proteins in the cytosol, and delivers them to the ER for insertion. (provided by
RefSeq, Oct 2011)

GeneCards Summary for ASNA1 Gene:
ASNA1 (arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)) is a protein-coding gene. Diseases associated with ASNA1 include breast adenoma. GO annotations related to this gene include arsenite transmembrane transporter activity and transporter activity.

UniProtKB/Swiss-Prot: ASNA_HUMAN, O43681
Function: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic
reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex
then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is
released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer
towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP
hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering
its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of
targeting (By similarity). May be involved in insulin signaling

Gene Wiki entry for ASNA1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the ASNA1 gene promoter:
         ER-alpha   Pax-5   Sp1   Pax-6   Nkx2-5   Tal-1beta   Arnt   CREB   GCNF-1   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidASNA1 promoter sequence
   Search Chromatin IP Primers for ASNA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ASNA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.13

ASNA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASNA1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P012848:  view genomic region     (about GC identifiers)

Start:
12,847,953 bp from pter      End:
12,859,137 bp from pter
Size:
11,185 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ASNA_HUMAN, O43681 (See protein sequence)
Recommended Name: ATPase ASNA1  
Size: 348 amino acids; 38793 Da
Subunit: Homodimer (By similarity). Component of a transmembrane domain recognition complex (TRC) (By similarity).
Interacts with SERP1 and SEC61B (By similarity). Interacts with WRB
Sequence caution: Sequence=AAC50731.1; Type=Frameshift; Positions=19;
Secondary accessions: A6NHP8 A8K740 Q53FC6 Q92849

Explore the universe of human proteins at neXtProt for ASNA1: NX_O43681

Explore proteomics data for ASNA1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys156, Lys317
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ASNA1 (O43681) (see all 11)
     YETERLIQ  NLFAMEID  ISTDPAHN  FDTAPTGHT 


    See ASNA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004308.2  
    ENSEMBL proteins: 
     ENSP00000466379   ENSP00000468450   ENSP00000349887  

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    Search eBioscience for ELISAs for ASNA1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR025723 Anion-transp_ATPase-like_dom
     IPR016300 ATPase_ArsA/GET3
     IPR027417 P-loop_NTPase
     IPR027542 ATPase_ArsA/GET3_euk

    Graphical View of Domain Structure for InterPro Entry O43681

    ProtoNet protein and cluster: O43681

    1 Blocks protein domain: IPB003348 Anion-transporting ATPase

    UniProtKB/Swiss-Prot: ASNA_HUMAN, O43681
    Similarity: Belongs to the arsA ATPase family


    Find genes that share domains with ASNA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ASNA_HUMAN, O43681
    Function: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic
    reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex
    then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is
    released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer
    towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP
    hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering
    its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of
    targeting (By similarity). May be involved in insulin signaling
    Biophysicochemical properties: Kinetic parameters: KM=0.22 mM for ATP; Vmax=16.6 nmol/min/mg enzyme for ATP;

         Enzyme Numbers (IUBMB): EC 3.6.3.162 EC 3.6.-.-1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity TAS9736449
    GO:0005524ATP binding IEA--
    GO:0015105arsenite transmembrane transporter activity TAS8884272
    GO:0016887ATPase activity IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ASNA1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ASNA1:
     Increased cell number in G1, s 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Asna1):
     mortality/aging 

    Find genes that share phenotypes with ASNA1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Asna1tm1Hbha for ASNA1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ASNA1
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    miRNA
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    miRTarBase miRNAs that target ASNA1:
    hsa-mir-26b-5p (MIRT029331), hsa-let-7b-5p (MIRT052086), hsa-mir-484 (MIRT042218)

    Block miRNA regulation of human, mouse, rat ASNA1 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate ASNA1:
    hsa-miR-185* hsa-miR-19b hsa-miR-625 hsa-miR-324-3p hsa-miR-2113 hsa-miR-19a
    SwitchGear 3'UTR luciferase reporter plasmidASNA1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ASNA1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ASNA_HUMAN, O43681: Cytoplasm. Endoplasmic reticulum. Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    nucleus5
    cytosol3
    cytoskeleton1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm TAS9736449
    GO:0005783endoplasmic reticulum IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with ASNA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including ASNA1: 
              Drug Metabolism in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ASNA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ASNA1 (O436812, 3 ENSP000003498874) via UniProtKB, MINT, STRING, and/or I2D (see all 187)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PFDN1O609252, 3MINT-8265698 I2D: score=2 
    TK1P041832, 3MINT-8272938 I2D: score=2 
    TTRP027662, 3MINT-8275721 I2D: score=2 
    CALM1P621583I2D: score=1 
    CALM2P621583I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS9736449
    GO:0015698inorganic anion transport TAS8884272
    GO:0045048protein insertion into ER membrane IEA--

    Find genes that share ontologies with ASNA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ASNA1 (ASNA)

    2 HMDB Compounds for ASNA1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ArsenicAs (see all 9)7440-38-2--
    ArseniteAArsenite (AsO33-) (see all 16)15502-74-6--

    1 DrugBank Compound for ASNA1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine triphosphate5'-ATP (see all 8)56-65-5target--17139284 17016423

    4 Novoseek inferred chemical compound relationships for ASNA1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    antimonite 96.7 10 1824941 (4), 1970649 (1), 9271073 (1), 12488319 (1)
    arsenite 85.4 8 8884272 (2), 19724867 (1), 9712828 (1), 7843081 (1) (see all 6)
    arsenate 82.5 2 1824941 (1), 9271073 (1)
    atp 27.3 5 1824941 (2), 1970649 (2)



    Find genes that share compounds with ASNA1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ASNA1 gene: 
    NM_004317.2  

    Unigene Cluster for ASNA1:

    ArsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
    Hs.465985  [show with all ESTs]
    Unigene Representative Sequence: AK293588
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000591090 ENST00000586561 ENST00000590633 ENST00000357332(uc002muv.3)

    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate ASNA1:
    hsa-miR-185* hsa-miR-19b hsa-miR-625 hsa-miR-324-3p hsa-miR-2113 hsa-miR-19a
    SwitchGear 3'UTR luciferase reporter plasmidASNA1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF047469.1 AK223363.1 AK291855.1 AK293588.1 BC002651.2 U60276.1 

    9 DOTS entries:

    DT.452642  DT.95109951  DT.121485366  DT.95109908  DT.100817852  DT.121485353  DT.121485356  DT.92444242 
    DT.97862213 

    Selected AceView cDNA sequences (see all 404):

    CB110142 BM741349 BG389726 BU179628 BE206701 NM_004317 CB266868 BQ069965 
    BE387880 BM791598 BX366084 BU628639 CA415996 BQ680654 CD675362 CF130991 
    BQ677959 BM928696 BC002651 BM920820 CR600502 BM710350 CR596298 CR604808 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ASNA1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
    SP1:                                                                  
    SP2:                                                                  
    SP3:        -                                                         


    ECgene alternative splicing isoforms for ASNA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ASNA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ASNA1 Expression
    About this image

    ASNA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ASNA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.465985

    UniProtKB/Swiss-Prot: ASNA_HUMAN, O43681
    Tissue specificity: Expressed in the epithelial cells of the liver, kidney, and stomach wall, in the adrenal
    medulla, in the islet cells of the pancreas, in the red pulp of the spleen, and in cardiac and skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Array including ASNA1: 
              Drug Metabolism in human mouse rat

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    QuantiFast Probe-based Assays in human, mouse, rat ASNA1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASNA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ASNA1 gene from Selected species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Asna11 , 5 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)1, 5 90.52(n)1
    99.71(a)1
      8 (41.48 cM)5
    564951  NM_019652.11  NP_062626.11 
     850179345 
    chicken
    (Gallus gallus)
    Aves ASNA16
    arsA arsenite transporter, ATP-binding, homolog 1 ...
    97(a)
    1 ↔ 1
    AADN03012371.1(21-1942)
    lizard
    (Anolis carolinensis)
    Reptilia ASNA16
    arsA arsenite transporter, ATP-binding, homolog 1 ...
    95(a)
    1 ↔ 1
    GL343286.1(841247-856529)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.118462 Transcribed sequence with strong similarity to protein more 83.39(n)    BX735124.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc565402 Transcribed sequence with strong similarity to protein more 79.44(n)    CA473094.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG15981 , 3 arsenite-transporting ATPase3
    CG15981
    68(a)3
    70.64(n)1
    69.11(a)1
      356901  NM_136452.31  NP_610296.21 
    worm
    (Caenorhabditis elegans)
    Secernentea ZK637.53
    asna-11
    ArsA3
    asna-11
    54(a)3
    56.35(n)1
    56.56(a)1
      III(8966811-8968223)3
    1762541  NM_066564.31  NP_498965.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GET3(YDL100C)4
    GET31
    Guanine nucleotide exchange factor for Gpa1p; amplifies more4
    GET31
    51.96(n)1
    50.48(a)1
      4(283176-282112)4
    8514581, 4  NP_010183.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G019101 AT1G01910 56.86(n)
    55.7(a)
      839305  NM_179244.1  NP_849575.1 
    rice
    (Oryza sativa)
    Liliopsida Os.157132 Oryza sativa (japonica cultivar-group) cDNA clone0 more 71.48(n)    AK105872.1 


    ENSEMBL Gene Tree for ASNA1 (if available)
    TreeFam Gene Tree for ASNA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ASNA1 gene

    Find genes that share paralogs with ASNA1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ASNA1
    PGOHUM00000242222


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ASNA1 (see all 277)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1820932161,2
    C--12847541(+) CTTCTA/GTTCCT 1 -- us2k10--------
    rs81774611,2
    C,F,H--12847552(+) GCTCTA/GAGACA 1 -- us2k17Minor allele frequency- G:0.01NS EA NA 546
    rs1861818581,2
    --12847658(+) GAATGG/TTGTCT 1 -- us2k10--------
    rs81774631,2
    C,F,H--12847716(+) GCCCAC/ATCTAA 1 -- us2k115Minor allele frequency- A:0.07NS EA NA WA 1628
    rs1905058021,2
    --12847835(+) CTGAGG/TTGAGG 1 -- us2k10--------
    rs81774641,2
    C,F--12847972(+) TAAGGT/AGAGGT 1 -- us2k18Minor allele frequency- A:0.06NS WA 766
    rs1409827691,2
    --12848023(+) AAAGAC/TATAGC 1 -- us2k10--------
    rs1819539881,2
    --12848079(+) GAGTAA/GCCTAG 1 -- us2k10--------
    rs1449179911,2
    --12848230(+) TCATGC/TTCCTA 1 -- us2k10--------
    rs1998916231,2
    --12848279(+) TTCTTC/TGTATG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ASNA1 (12847953 - 12859137 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ASNA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911077CNV Loss21882294
    dgv3733n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ASNA1
    DNA2.0 Custom Variant and Variant Library Synthesis for ASNA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601913    OMIM disorders: --

    1 disease for ASNA1:    
    About MalaCards
    breast adenoma


    Find genes that share disorders with ASNA1           About GenesLikeMe

    Genetic Association Database (GAD): ASNA1

    Export disorders for ASNA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ASNA1 gene, integrated from 10 sources (see all 51):
    (articles sorted by number of sources associating them with ASNA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of the ATP-binding human homolog of the arsA component of the bacterial arsenite transporter. (PubMed id 8884272)1, 2, 3, 9 Kurdi-Haidar B....Howell S.B. (Genomics 1996)
    2. Identification of a targeting factor for posttranslational membrane protein insertion into the ER. (PubMed id 17382883)1, 2, 3 Stefanovic S. and Hegde R.S. (Cell 2007)
    3. Biochemical characterization of the human arsenite-stimulated ATPase (hASNA-I). (PubMed id 9712828)1, 2, 9 Kurdi-Haidar B.... Howell S.B. (J. Biol. Chem. 1998)
    4. WRB is the receptor for TRC40/Asna1-mediated insertion of tail- anchored proteins into the ER membrane. (PubMed id 21444755)1, 2 Vilardi F.... Dobberstein B. (J. Cell Sci. 2011)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Dual cytoplasmic and nuclear distribution of the novel arsenite- stimulated human ATPase (hASNA-I). (PubMed id 9736449)1, 2 Kurdi-Haidar B.... Howell S.B. (J. Cell. Biochem. 1998)
    7. ASNA-1 positively regulates insulin secretion in C. elegans and mammalian cells. (PubMed id 17289575)1, 9 Kao G....Naredi P. (Cell 2007)
    8. Increased sensitivity to platinating agents and arsenite in human ovarian cancer by downregulation of ASNA1. (PubMed id 19724867)1, 9 Hemmingsson O....Naredi P. (Oncol. Rep. 2009)
    9. Immunohistochemical analysis of the distribution of the human ATPase (hASNA-I) in normal tissues and its overexpression in breast adenomas and carcinomas. (PubMed id 9774623)2, 9 Kurdi-Haidar B.... Howell S.B. (J. Histochem. Cytochem. 1998)
    10. Tail-anchored PEX26 targets peroxisomes via a PEX19-dependent and TRC40-independent class I pathway. (PubMed id 23460677)1 Yagita Y....Fujiki Y. (J. Cell Biol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 439 HGNC: 752 AceView: ASNA1 Ensembl:ENSG00000198356 euGenes: HUgn439
    ECgene: ASNA1 H-InvDB: ASNA1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ASNA1 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/asna1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ASNA1 gene:
    Search GeneIP for patents involving ASNA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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