Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ASMTL Gene

Aliases for ASMTL Gene

  • Acetylserotonin O-Methyltransferase-Like 2 3
  • N-Acetylserotonin O-Methyltransferase-Like Protein 3
  • Acetylserotonin N-Methyltransferase-Like 3
  • EC 2.1.1.- 4
  • ASMTLX 3
  • ASMTLY 3
  • ASTML 3

External Ids for ASMTL Gene

Previous GeneCards Identifiers for ASMTL Gene

  • GC0XM000997
  • GC0XM000838
  • GC0XM001102
  • GC0XM001167
  • GC0YM001565
  • GC0XM001565
  • GC0XM001482
  • GC0XM001522

Summaries for ASMTL Gene

Entrez Gene Summary for ASMTL Gene

  • The protein encoded by this gene has an N-terminus that is similar to the multicopy associated filamentation (maf) protein of Bacillus subtilis and to orfE of Escherichia coli, while the C-terminus is similar to N-acetylserotonin O-methyltransferase. This gene is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

GeneCards Summary for ASMTL Gene

ASMTL (Acetylserotonin O-Methyltransferase-Like) is a Protein Coding gene. Diseases associated with ASMTL include patau syndrome. GO annotations related to this gene include O-methyltransferase activity. An important paralog of this gene is ASMT.

UniProtKB/Swiss-Prot for ASMTL Gene

  • Unknown. The presence of the putative catalytic domain of S-adenosyl-L-methionine binding argues for a methyltransferase activity

Gene Wiki entry for ASMTL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASMTL Gene

Genomics for ASMTL Gene

Regulatory Elements for ASMTL Gene

Genomic Location for ASMTL Gene

Start:
1,403,139 bp from pter
End:
1,453,794 bp from pter
Size:
50,656 bases
Orientation:
Minus strand

Genomic View for ASMTL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ASMTL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASMTL Gene

Proteins for ASMTL Gene

  • Protein details for ASMTL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95671-ASML_HUMAN
    Recommended name:
    N-acetylserotonin O-methyltransferase-like protein
    Protein Accession:
    O95671
    Secondary Accessions:
    • B4DX75
    • F5GXH4
    • J3JS33
    • Q5JQ53
    • Q8NBH5
    • Q96G02
    • Q9BUL6

    Protein attributes for ASMTL Gene

    Size:
    621 amino acids
    Molecular mass:
    68857 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. It represents a unique fusion product of 2 different genes of different evolutionary origin and function. The N-terminus is homologous to the bacterial maf/orfE genes and the C-terminus is homologous to ASMT. Exon duplication, exon shuffling and gene fusion seem to be common characteristics of the PAR1 region
    SequenceCaution:
    • Sequence=CAA75675.1; Type=Frameshift; Positions=616; Evidence={ECO:0000305}; Sequence=CAA75676.1; Type=Frameshift; Positions=616; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ASMTL Gene

    Alternative splice isoforms for ASMTL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASMTL Gene

Proteomics data for ASMTL Gene at MOPED

Post-translational modifications for ASMTL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ASMTL Gene

No data available for DME Specific Peptides for ASMTL Gene

Domains for ASMTL Gene

Gene Families for ASMTL Gene

HGNC:
  • PAR1 :Pseudoautosomal regions / PAR1

Suggested Antigen Peptide Sequences for ASMTL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95671

UniProtKB/Swiss-Prot:

ASML_HUMAN :
  • O95671
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
  • In the N-terminal section; belongs to the maf family.
genes like me logo Genes that share domains with ASMTL: view

Function for ASMTL Gene

Molecular function for ASMTL Gene

GENATLAS Biochemistry: acetylserotonin methyltransferase-like due to a unique fusion product of two genes of different evolutionary origin and function,(see ASMTLY)
UniProtKB/Swiss-Prot Function: Unknown. The presence of the putative catalytic domain of S-adenosyl-L-methionine binding argues for a methyltransferase activity

Enzyme Numbers (IUBMB) for ASMTL Gene

Gene Ontology (GO) - Molecular Function for ASMTL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 16189514
GO:0008171 O-methyltransferase activity IEA --
genes like me logo Genes that share ontologies with ASMTL: view

miRNA for ASMTL Gene

miRTarBase miRNAs that target ASMTL

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ASMTL Gene

Localization for ASMTL Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ASMTL Gene COMPARTMENTS Subcellular localization image for ASMTL gene
Compartment Confidence
mitochondrion 3
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ASMTL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ASMTL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ASMTL Gene

Pathways for ASMTL Gene

SuperPathways for ASMTL Gene

No Data Available

Gene Ontology (GO) - Biological Process for ASMTL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with ASMTL: view

No data available for Pathways by source for ASMTL Gene

Compounds for ASMTL Gene

(1) HMDB Compounds for ASMTL Gene

Compound Synonyms Cas Number PubMed IDs
S-Adenosylmethionine
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
29908-03-0
genes like me logo Genes that share compounds with ASMTL: view

Transcripts for ASMTL Gene

Unigene Clusters for ASMTL Gene

Acetylserotonin O-methyltransferase-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ASMTL Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14
SP1: - - -
SP2: -
SP3:
SP4: - - - - -
SP5:
SP6: -
SP7:

Relevant External Links for ASMTL Gene

GeneLoc Exon Structure for
ASMTL
ECgene alternative splicing isoforms for
ASMTL

Expression for ASMTL Gene

mRNA expression in normal human tissues for ASMTL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ASMTL Gene

SOURCE GeneReport for Unigene cluster for ASMTL Gene Hs.533514

mRNA Expression by UniProt/SwissProt for ASMTL Gene

O95671-ASML_HUMAN
Tissue specificity: Widely expressed. In adult, highly expressed in pancreas, placenta, fibroblast, thymus, prostate, testis, ovary and colon. Expressed at lower levels in spleen, small intestine and leukocytes. In fetus, expressed at high levels in the lung and kidney and at lower level in brain and liver
genes like me logo Genes that share expressions with ASMTL: view

No data available for mRNA differential expression in normal tissues for ASMTL Gene

Orthologs for ASMTL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ASMTL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ASMTL 35
  • 97.74 (n)
  • 95.76 (a)
ASMTL 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ASMTL 35
  • 71.73 (n)
  • 62.42 (a)
ASMTL 36
  • 58 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ASMTL 35
  • 75.06 (n)
  • 68.61 (a)
ASMTL 36
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ASMTL 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ASMTL 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Asmtl 35
  • 58.68 (n)
  • 49.77 (a)
chicken
(Gallus gallus)
Aves ASMTL 35
  • 63.19 (n)
  • 62.48 (a)
ASMTL 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ASMTL 36
  • 61 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25671 35
tropical clawed frog
(Silurana tropicalis)
Amphibia asmtl 35
  • 59.38 (n)
  • 59.05 (a)
Str.17108 35
zebrafish
(Danio rerio)
Actinopterygii asmtl 35
  • 58.21 (n)
  • 56.34 (a)
asmtl 36
  • 52 (a)
OneToOne
wufc48g07 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008707 35
  • 52.81 (n)
  • 46.04 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9515 35
  • 46.8 (n)
  • 43.35 (a)
CG9515 36
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dod-18 35
  • 45.34 (n)
  • 38.17 (a)
dod-18 36
  • 13 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL225W 35
  • 50.69 (n)
  • 38.02 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 12 (a)
OneToMany
YOR111W 35
  • 48.5 (n)
  • 38 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F23628g 35
  • 46.47 (n)
  • 39.41 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03130 35
  • 54.17 (n)
  • 44 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC3G6.03c 35
  • 46.01 (n)
  • 41.67 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 18 (a)
OneToMany
Species with no ortholog for ASMTL:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ASMTL Gene

ENSEMBL:
Gene Tree for ASMTL (if available)
TreeFam:
Gene Tree for ASMTL (if available)

Paralogs for ASMTL Gene

Paralogs for ASMTL Gene

Selected SIMAP similar genes for ASMTL Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ASMTL: view

Variants for ASMTL Gene

Sequence variations from dbSNP and Humsavar for ASMTL Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
VAR_054802 -
VAR_054803 -

Structural Variations from Database of Genomic Variants (DGV) for ASMTL Gene

Variant ID Type Subtype PubMed ID
esv29996 CNV Loss 17803354
dgv1357e201 CNV Deletion 23290073
esv2666429 CNV Deletion 23128226
esv2739698 CNV Deletion 23290073
esv2739703 CNV Deletion 23290073
esv2667783 CNV Deletion 23128226
esv2669866 CNV Deletion 23128226
esv2739704 CNV Deletion 23290073
esv2739705 CNV Deletion 23290073
esv2678263 CNV Deletion 23128226
esv2739706 CNV Deletion 23290073
esv2739708 CNV Deletion 23290073
esv2196117 CNV Deletion 18987734
esv2739709 CNV Deletion 23290073
esv2739710 CNV Deletion 23290073
dgv1359e201 CNV Deletion 23290073
esv2739712 CNV Deletion 23290073
esv2246827 CNV Deletion 18987734
esv2739714 CNV Deletion 23290073
dgv1360e201 CNV Deletion 23290073
esv2739716 CNV Deletion 23290073
esv2739719 CNV Deletion 23290073
esv2739720 CNV Deletion 23290073
esv2666911 CNV Deletion 23128226
esv1981196 CNV Deletion 18987734

Relevant External Links for ASMTL Gene

HapMap Linkage Disequilibrium report
ASMTL
Locus Specific Mutation Databases (LSDB)
ASMTL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASMTL Gene

Disorders for ASMTL Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ASMTL Gene including...

Search for ASMTL Gene in MalaCards »

(1) University of Copenhagen DISEASES for ASMTL Gene

genes like me logo Genes that share disorders with ASMTL: view

No data available for UniProtKB/Swiss-Prot for ASMTL Gene

Publications for ASMTL Gene

  1. Gene duplications as a recurrent theme in the evolution of the human pseudoautosomal region 1: isolation of the gene ASMTL. (PMID: 9736779) Ried K. … Rappold G.A. (Hum. Mol. Genet. 1998) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for ASMTL Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ASMTL
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ASMTL
    • Block miRNA regulation of ASMTL using miScript Target Protectors

    Sources for ASMTL Gene

    Back to Top

    Content