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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ASMT Gene

protein-coding GIFtS: 59
GCID: GC0XP001674

acetylserotonin O-methyltransferase

Explore 13 diseases affiliated with
ASMT via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Acetylserotonin O-Methyltransferase¹ ²		Hydroxyindole O-Methyltransferase² ³
HIOMT¹ ² ³ ⁵		Acetylserotonin Methyltransferase (Y Chromosome)²
ASMTY¹ ²		Acetylserotonin N-Methyltransferase²
HIOMTY¹ ²		EC 2.1.1.4³

External Ids:	HGNC: 750¹	Entrez Gene: 438²	Ensembl: ENSG00000196433⁷	OMIM: 300015⁵	UniProtKB: P46597³

Export aliases for ASMT gene to outside databases

Previous GC identifers: GC0XP001185 GC0XP001125 GC0XP001294 GC0XP001359 GC0XP001356 GC0YP001758 GC0XP001758

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ASMT:

This gene belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the end

of the short arms of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of

melatonin, and is abundant in the pineal gland. Alternatively spliced transcript variants have been noted for this

gene. (provided by RefSeq, Jan 2010)

UniProtKB/Swiss-Prot: ASMT_HUMAN, P46597

Function: Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin

(N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity

Gene Wiki entry for ASMT (Acetylserotonin O-methyltransferase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_000024.9 NC_018934.1 NT_167196.1 NT_167204.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ASMT gene promoter:
PPAR-alpha p53 RelA NF-kappaB NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ASMT promoter sequence

Search SABiosciences Chromatin IP Primers for ASMT

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASMT

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.3 or Yp11.3 Ensembl cytogenetic band: Xp22.33 HGNC cytogenetic band: Xp22.3 and Yp11.3

ASMT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASMT gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP001674: view genomic region (about GC identifiers)

Start:	1,714,348 bp from pter	End:	1,761,974 bp from pter
Size:	47,627 bases	Orientation:	plus strand

1 alternative location:

ChrY+ 1,664,348-1,711,974

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ASMT_HUMAN, P46597 (See protein sequence)

Recommended Name: Acetylserotonin O-methyltransferase

Size: 345 amino acids; 38453 Da

Subunit: Homodimer

Miscellaneous: The gene encoding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y

chromosomes

2 PDB 3D structures from and Proteopedia for ASMT:

4A6D (3D)

4A6E (3D)

Secondary accessions: B2RC33 Q16598 Q5JQ72 Q5JQ73

Alternative splicing: 3 isoforms: P46597-1 P46597-2 P46597-3 (Includes part of a LINE-1 element. Ref.1 (AAA58582/AAA58583/AAA75290), Ref.2 (AAA17020) and Ref.3 (BAG37430) sequences are in conflict in position: 190:W->R)

Explore the universe of human proteins at neXtProt for ASMT: NX_P46597

ASMT Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001164509.1 NP_001164510.1 NP_004034.2

ENSEMBL proteins:

ENSP00000370639 ENSP00000370627 ENSP00000370631 ENSP00000392053

Reactome Protein details: P46597
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	Uscn Proteins for ASMT

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--

ASMT for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for ASMT

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ASMT for domains About GeneDecksing

4 InterPro domains/families:

IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom

IPR001077 O_MeTrfase_2

IPR025781 AS_MeTrfase

IPR016461 O-MeTrfase_CAOMT-type

Graphical View of Domain Structure for InterPro Entry P46597

ProtoNet protein and cluster: P46597

1 Blocks protein family: IPB001077 O-methyltransferase

UniProtKB/Swiss-Prot: ASMT_HUMAN, P46597

Similarity: Belongs to the methyltransferase superfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ASMT_HUMAN, P46597

Function: Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin

(N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity

Catalytic activity: S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin

Induction: By all-trans-, 9-cis- and 13-cis-retinoic acid and by serum treatment, following starvation, in the

retinoblastoma cell line Y79

Genatlas biochemistry entry for ASMT:

methyltransferase,hydroxyindole-O,catalyzing the final step of melatonin synthesis,expressed in the pineal gland

Enzyme Number (IUBMB): EC 2.1.1.4¹

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASMT

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008171	O-methyltransferase activity	TAS	8397829
GO:0017096	acetylserotonin O-methyltransferase activity	IDA	--
GO:0042802	identical protein binding	IPI	--
GO:0042803	protein homodimerization activity	IPI	--

ASMT for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Regulation of thyroid hormone activity

	Amine-derived hormones	0.21			Serotonin and melatonin biosynthesis	0.00
	serotonin and melatonin biosynthesis	0.00			Biogenic Amine Synthesis	0.00

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

Tryptophan metabolism

Tryptophan metabolism

1.00

Tryptophan metabolism

0.47

Metabolism of amino acids and derivatives

Metabolism of amino acids and derivatives

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

3 BioSystems Pathways for ASMT

	Biogenic Amine Synthesis
	serotonin and melatonin biosynthesis
	Tryptophan metabolism

4 Reactome Pathways for ASMT

	Amine-derived hormones
	Serotonin and melatonin biosynthesis
	Metabolism
	Metabolism of amino acids and derivatives

2 Kegg Pathways (Kegg details for ASMT):

	Tryptophan metabolism
	Metabolic pathways

UniProtKB/Swiss-Prot: ASMT_HUMAN, P46597

Pathway: Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2

ASMT for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ASMT

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

5/12 Interacting proteins for ASMT (P46597¹ ENSP00000370639⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 12)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ASMT	P46597¹	EBI-6502097,EBI-6502097
AANAT	ENSP00000250615⁴	STRING: ENSP00000250615
ALDH1B1	ENSP00000366927⁴	STRING: ENSP00000366927
ALDH2	ENSP00000261733⁴	STRING: ENSP00000261733
ALDH3A2	ENSP00000345774⁴	STRING: ENSP00000345774

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006412	translation	TAS	8397829
GO:0030187	melatonin biosynthetic process	IEA	--
GO:0034641	cellular nitrogen compound metabolic process	TAS	--
GO:0044281	small molecule metabolic process	TAS	--
GO:0046219	indolalkylamine biosynthetic process	TAS	--

ASMT for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ASMT for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for ASMT

Browse Tocris compounds for ASMT

6 HMDB Compounds for ASMT About this table

Compound	Synonyms	CAS #	PubMed Ids
Melatonin	5-Methoxy-N-acetyltryptamine (see all 23)	73-31-4	180879
5-Hydroxyindoleacetic acid	5-Hydroxy-1H-indole-3-acetate (see all 18)	54-16-0	--
5-Methoxyindoleacetate	5-Methoxyindol-3-ylacetate (see all 8)	608-07-1	--
N-Acetylserotonin	5-Hydroxy-N-acetyltryptamine (see all 5)	1210-83-9	--
S-Adenosylhomocysteine	(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)	979-92-0	--
S-Adenosylmethionine	(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)	29908-03-0	--

1 DrugBank Compound for ASMT About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Melatonin	MEL (see all 4)	73-31-4	target	--	180879
Melatonin	MEL (see all 4)	73-31-4	enzyme	substrate	180879 180879

7 Novoseek chemical compound relationships for ASMT gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
arylalkylamine	90.6	8	10338362 (1), 16150106 (1), 20377855 (1), 10496148 (1) (see all 8)
melatonin	84.2	66	20377855 (3), 10801305 (3), 10338362 (2), 10496148 (2) (see all 31)
dbc-amp	43	9	10496148 (4), 2162375 (1)
cyclic amp	38.2	2	2054606 (1), 10496148 (1)
butyrate	31.9	10	10496148 (5), 2162375 (1)
5-hydroxytryptamine	25.1	1	14675129 (1)
oligonucleotide	6.09	2	8397829 (1)

Search CenterWatch for drugs/clinical trials and news about ASMT

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ASMT gene (3 alternative transcripts):

NM_001171038.1 NM_001171039.1 NM_004043.2

Unigene Cluster for ASMT:

Acetylserotonin O-methyltransferase

Hs.522572 [show with all ESTs]

Unigene Representative Sequence: NR_027383

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000381241(uc004cqd.3 uc010ncy.3 uc004cqe.3) ENST00000381229

ENST00000381233 ENST00000432523

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Additional cDNA sequence:

AK308367.1 AK314922.1 AY037933.1 BC001620.1 BC015800.1 BC016935.1 BC028151.1 BC110496.1

BC110497.1 L03426.1 M83779.1 M99578.1 NR_027383.1 U11090.1 U11091.1

24/30 DOTS entries (see all 30):

DT.100672944 DT.91867980 DT.100802797 DT.209941 DT.120653611 DT.121323179 DT.121323194 DT.75172484

DT.100748362 DT.121323191 DT.75140614 DT.95122194 DT.100000439 DT.121323164 DT.120653594 DT.121323176

DT.116247 DT.121323170 DT.121323173 DT.91733938 DT.91789023 DT.95290492 DT.120653545 DT.121166704

24/301 AceView cDNA sequences (see all 301):

BE646344 BE676308 BG056975 AI189957 BX091147 NM_004043 AI083532 BU629522

BU788998 AW978405 AA975839 BE857665 AW003492 BC028151 AI129402 NM_005088

U11091 AI810064 BM510017 BE858964 CK825104 BQ930425 BF854430 CR620922

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ASMT About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	·	4c	^	5	^	6	^	7	^	8a	·	8b	·	8c	·	8d	^	9
SP1:													-								-		-
SP2:													-				-		-		-		-
SP3:															-		-		-
SP4:

ECgene alternative splicing isoforms for ASMT

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ASMT expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image
See ASMT Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ASMT

SOURCE GeneReport for Unigene cluster: Hs.522572

UniProtKB/Swiss-Prot: ASMT_HUMAN, P46597

Tissue specificity: Expressed in the pineal gland (at protein level). In the retina, very low expression is found at

the mRNA level (PubMed:7989373), and not at the protein level (PubMed:8574683)

SABiosciences Expression via Pathway-Focused PCR Array including ASMT:

Drug Metabolism: Phase II Enzymes in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ASMT gene from 6/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ASMT¹	acetylserotonin O-methyltransferase	62.51(n) 57.1(a)		396286 NM_205343.1 NP_990674.1
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 7)	--	56(a) 48(a) (see all 7)	many → 1 many → 1 (see all 7)	3(113364919-113384627) 2(41562071-41574797)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.8492²	Transcribed sequence with weak similarity to protein spP46597 (H.sapiens) HIOM_HUMAN Hydroxyindole O-methyltransferase (HIOMT) (Acetylserotonin O-methyltransferase) (ASMT) less	71(n)		CF591017.1
zebrafish (Danio rerio)	Actinopterygii	asmt¹	acetylserotonin O-methyltransferase	61.11(n) 51.82(a)		100141344 NM_001114909.1 NP_001108381.1
thale cress (Arabidopsis thaliana)	eudicotyledons	OMT1¹	Quercetin 3-O-methyltransferase 1	41.97(n) 28.52(a)		835504 NM_124796.3 NP_200227.1
rice (Oryza sativa)	Liliopsida	Os08g0157500¹	hypothetical protein	46.71(n) 28.4(a)		4344702 NM_001067566.1 NP_001061031.1

Species with no ortholog for ASMT

ENSEMBL Gene Tree for ASMT (if available)
TreeFam Gene Tree for ASMT (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ASMT gene

ASMTL²

1 SIMAP similar gene for ASMT using alignment to 2 protein entries: ASMT_HUMAN (see all proteins):

ASMTL

ASMT for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 14 variations for ASMT
11 CNVs: 97147 73910 83261 83259 73908 73909 96390 83898 83899 83260 83258
3 Indels: 47793 47791 47792
Human Gene Mutation Database (HGMD): ASMT

Locus Specific Mutation Databases (LSDB): ASMT

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ASMT

DNA2.0 Custom Variant and Variant Library Synthesis for ASMT

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ASMT for disorders           About GeneDecksing

OMIM gene information: 300015    OMIM disorders: --

13 diseases for ASMT:    About MalaCards

pineocytoma pineoblastoma autism spectrum disorder intellectual disability

insomnia glaucoma retinoblastoma homocysteine

cholangiocarcinoma retinitis schizophrenia tuberculosis

mycobacterium tuberculosis

1 disease from the University of Copenhagen DISEASES database for ASMT:

Pineoblastoma

5 Novoseek disease relationships for ASMT gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pineocytoma	82.4	6	10831155 (4), 16825954 (1)
pineal tumors	79.6	2	10831155 (1)
pineoblastoma	79.2	6	10831155 (4), 16825954 (1)
retinoblastoma	58.6	5	10496148 (2), 8842389 (1), 2162375 (1), 8574683 (1)
tumors	0	6	10831155 (2), 20418777 (1)

Human Genome Epidemiology (HuGE) Navigator: ASMT (4 documents)

Export disorders for ASMT gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ASMT gene, integrated from 9 sources (see all 56):
(articles sorted by number of sources associating them with ASMT)

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Human hydroxyindole-O-methyltransferase: presence of LINE-1 fragment in a cDNA clone and pineal mRNA. (PubMed id 8397829)^{1, 2, 3, 9} Donohue S.J.... Klein D.C. (1993)
Structural analysis of the human hydroxyindole-O-methyltransferase gene. Presence of two distinct promoters. (PubMed id 7989373)^{1, 2, 3, 9} Rodriguez I.R....Chader G.J. (1994)
Genetic and functional abnormalities of the melatonin biosynthesis pathway in patients with bipolar disorder. (PubMed id 22694957)^{1, 2} Etain B.... Jamain S. (2012)
Mutation screening of ASMT, the last enzyme of the me latonin pathway, in a large sample of patients with intellectual disability. (PubMed id 21251267)^{1, 2} Pagan C....Bourgeron T. (2011)
Genetic variations of the melatonin pathway in patient s with attention-deficit and hyperactivity disorders. (PubMed id 21615493)^{1, 2} Chaste P....Bourgeron T. (2011)
Abnormal melatonin synthesis in autism spectrum disorders. (PubMed id 17505466)^{1, 2} Melke J....Bourgeron T. (2008)
Is ASMT a susceptibility gene for autism spectrum disorders? A replication study in European populations. (PubMed id 17957233)^{1, 2} Toma C....Maestrini E. (2007)
The DNA sequence of the human X chromosome. (PubMed id 15772651)^{1, 2} Ross M.T.... Bentley D.R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The pharmacology of the pineal gland. (PubMed id 180879)^{6, 7} Minneman K.P. and Wurtman R.J. (1976)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 438	HGNC: 750	AceView: ASMT.1	Ensembl:ENSG00000196433	euGenes: HUgn438
ECgene: ASMT	Kegg: 438	H-InvDB: ASMT

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ASMT	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/5-hydroxyindole-O-methyltransferase

Intellectual Property for ASMT gene
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Patent Information for ASMT gene:
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acetylserotonin O-methyltransferase

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acetylserotonin O-methyltransferase

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