Aliases for ASMT Gene
Aliases for ASMT Gene
External Ids for ASMT Gene
Previous GeneCards Identifiers for ASMT Gene
- GC0XP001185
- GC0XP001125
- GC0XP001294
- GC0XP001359
- GC0XP001356
- GC0YP001758
- GC0XP001758
- GC0XP001714
Summaries for ASMT Gene
-
This gene belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin, and is abundant in the pineal gland. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2010]
GeneCards Summary for ASMT Gene
ASMT (Acetylserotonin O-Methyltransferase) is a Protein Coding gene. Diseases associated with ASMT include Pineoblastoma and Pineocytoma. Among its related pathways are Amine-derived hormones and Viral mRNA Translation. GO annotations related to this gene include protein homodimerization activity and methyltransferase activity. An important paralog of this gene is ASMTL.
UniProtKB/Swiss-Prot for ASMT Gene
-
Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASMT Gene
Genomics for ASMT Gene
Regulatory Elements for ASMT Gene
Enhancers for ASMT Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH0XG001405 | 0.7 | FANTOM5 | 8.4 | -189.8 | -189798 | 0.3 | HDGF ZNF114 ZNF473 ZNF571 YBX1 ZNF776 ZNF366 IKZF1 TARDBP EED | AKAP17A ASMT ASMTL SLC25A6 CRLF2 P2RY8 CSF2RA IL3RA ASMTL-AS1 |
| GH0XG001471 | 1.5 | FANTOM5 Ensembl dbSUPER | 2.9 | -123.5 | -123455 | 0.8 | HDGF ATF1 ARID4B DMAP1 YY1 GLIS2 ELK1 SP3 JUNB TBX21 | P2RY8 AKAP17A ASMTL ASMT CSF2RA |
| GH0XG001395 | 0.7 | FANTOM5 | 6.1 | -199.6 | -199620 | 0.3 | HDGF ZFHX2 ZNF366 IKZF1 TARDBP YBX1 PCBP1 EGR2 | ASMT AKAP17A SLC25A6 ASMTL LINC00106 |
| GH0XG001500 | 1.5 | FANTOM5 Ensembl dbSUPER | 2.4 | -92.4 | -92355 | 5.0 | HDGF PKNOX1 ATF1 CREB3L1 ZNF48 ZNF121 ZNF766 GATA2 ELK1 ZNF207 | P2RY8 AKAP17A CSF2RA IL3RA ASMTL ASMT CRLF2 SLC25A6 |
| GH0XG001247 | 1.2 | FANTOM5 Ensembl | 2.8 | -346.3 | -346271 | 2.4 | TBP ETS1 ZNF121 ZNF366 FOS ETV6 USF2 REST NR2F2 RAD51 | CSF2RA IL3RA ASMTL AKAP17A CRLF2 ASMT P2RY8 SLC25A6 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ASMT on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the ASMT gene promoter:
Regulatory Element Products
Genomic Location for ASMT Gene
- Chromosome:
- X
- Start:
- 1,595,455 bp from pter
- End:
- 1,643,081 bp from pter
- Size:
- 47,627 bases
- Orientation:
- Plus strand
Genomic View for ASMT Gene
Genes around ASMT on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xp22.33 by Ensembl
- Xp22.33 and Yp11.2 by Entrez Gene
- Xp22.3 and Yp11.3 by HGNC
ASMT Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ASMT Gene
Proteins for ASMT Gene
-
Protein details for ASMT Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P46597-ASMT_HUMAN
- Recommended name:
- Acetylserotonin O-methyltransferase
- Protein Accession:
- P46597
- B2RC33
- Q16598
- Q5JQ72
- Q5JQ73
Protein attributes for ASMT Gene
- Size:
- 345 amino acids
- Molecular mass:
- 38453 Da
- Quaternary structure:
-
- Homodimer.
- Miscellaneous:
-
- The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.
Protein Expression for ASMT Gene
Post-translational modifications for ASMT Gene
No Post-translational modifications
Other Protein References for ASMT Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ASMT
- Invitrogen Antibodies for ASMT
- antibodies-online Antibodies for ASMT: See all 40
- GeneTex ASMT antibody for ASMT
Protein Products
-
OriGene Purified Proteins for ASMT
- Search Origene for MassSpec and Protein Over-expression Lysates for ASMT
- Origene Custom Protein Services for ASMT
- ProSpec Recombinant Proteins for ASMT
- antibodies-online Proteins for ASMT: See all 13
- Search antibodies-online for peptides
- Search GeneTex for Proteins for ASMT
Assay Products
- antibodies-online Kits for ASMT: See all 6
No data available for DME Specific Peptides for ASMT Gene
Domains & Families for ASMT Gene
Gene Families for ASMT Gene
Protein Domains for ASMT Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ASMT Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P46597UniProtKB/Swiss-Prot:
ASMT_HUMAN :- Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
- Family:
-
- Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
Function for ASMT Gene
Molecular function for ASMT Gene
- GENATLAS Biochemistry:
- methyltransferase,hydroxyindole-O,catalyzing the final step of melatonin synthesis,expressed in the pineal gland
- UniProtKB/Swiss-Prot CatalyticActivity:
- S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin.
- UniProtKB/Swiss-Prot Function:
- Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity.
- UniProtKB/Swiss-Prot Induction:
- By all-trans-, 9-cis- and 13-cis-retinoic acid and by serum treatment, following starvation, in the retinoblastoma cell line Y79.
Enzyme Numbers (IUBMB) for ASMT Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008168 | methyltransferase activity | IEA | -- |
| GO:0008171 | O-methyltransferase activity | IEA,TAS | 8397829 |
| GO:0008172 | S-methyltransferase activity | TAS | -- |
| GO:0008757 | S-adenosylmethionine-dependent methyltransferase activity | IEA | -- |
| GO:0016740 | transferase activity | IEA | -- |
Phenotypes for ASMT Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ASMT
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ASMT gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ASMT gene
- Search ViGene Biosciences for ASMT
CRISPR Products
-
OriGene CRISPR knockouts for ASMT
miRNA Products
- Search ViGene Biosciences for ASMT
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ASMT
- Browse OriGene Inhibitory RNA Products For ASMT
-
ViGene Biosciences ready-to-package AAV shRNAs for ASMT gene
Clone Products
- Sino Biological Human cDNA Clone for ASMT
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ASMT
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ASMT
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ASMT
-
ViGene Biosciences adenoviral particle packaged cDNA for ASMT gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ASMT gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ASMT gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ASMT Gene
Localization for ASMT Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| mitochondrion | 2 |
| extracellular | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for ASMT Gene
Pathways & Interactions for ASMT Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Metabolism |
.37
|
|
| 2 | superpathway of tryptophan utilization | ||
| 3 | Amine-derived hormones | ||
| 4 | Viral mRNA Translation | ||
| 5 | Biogenic Amine Synthesis | ||
Pathways by source for ASMT Gene
2 BioSystems pathways for ASMT Gene
4 Reactome pathways for ASMT Gene
2 KEGG pathways for ASMT Gene
UniProtKB/Swiss-Prot P46597-ASMT_HUMAN
- Pathway: Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.
Interacting Proteins for ASMT Gene
Selected Interacting proteins:
P46597-ASMT_HUMAN
ENSP00000370639
for ASMT Gene via
IID
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006412 | translation | TAS | 8397829 |
| GO:0030187 | melatonin biosynthetic process | IEA | -- |
| GO:0032259 | methylation | IEA | -- |
| GO:0046219 | indolalkylamine biosynthetic process | TAS | -- |
No data available for SIGNOR curated interactions for ASMT Gene
Drugs & Compounds for ASMT Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 5-Hydroxyindoleacetic acid |
|
54-16-0 |
|
|||
| 5-Methoxyindoleacetate |
|
608-07-1 |
|
|||
| n-acetylserotonin |
|
1210-83-9 |
|
Drug Products
- Enzo Life Sciences drugs & compounds for ASMT
Transcripts for ASMT Gene
mRNA/cDNA for ASMT Gene
- (3) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (277) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ASMT Gene
CRISPR Products
-
OriGene CRISPR knockouts for ASMT
miRNA Products
- Search ViGene Biosciences for ASMT
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ASMT
- Browse OriGene Inhibitory RNA Products For ASMT
-
ViGene Biosciences ready-to-package AAV shRNAs for ASMT gene
Clone Products
- Sino Biological Human cDNA Clone for ASMT
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ASMT
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ASMT
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||
| SP4: |
Expression for ASMT Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
This gene is overexpressed in Heart (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ASMT Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ASMT Gene:
ASMTSOURCE GeneReport for Unigene cluster for ASMT Gene:
Hs.522572mRNA Expression by UniProt/SwissProt for ASMT Gene:
P46597-ASMT_HUMAN
Tissue specificity:
Expressed in the pineal gland (at protein level). In the retina, very low expression is found at the mRNA level (PubMed:7989373), and not at the protein level (PubMed:8574683).
Evidence on tissue expression from TISSUES for ASMT Gene
- Nervous system(4.7)
- Eye(4.6)
- Intestine(2.4)
Primer Products
-
OriGene qPCR primer pairs for ASMT
-
OriGene qPCR primer pairs and template standards for ASMT
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ASMT Gene
Orthologs for ASMT Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| dog (Canis familiaris) |
Mammalia | ASMT 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | ASMT 35 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Asmt 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ASMT 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ASMT 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Asmt 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ASMT 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | asmt 34 |
|
||
| Str.8492 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | asmt 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG9515 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | dod-18 35 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | -- 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for ASMT was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ASMT Gene
(1) SIMAP similar genes for ASMT Gene using alignment to 2 proteins:
Variants for ASMT Gene
| SNP ID | Clin | Chr 0X pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs199647924 | Uncertain significance | 1,623,156(+) | GCCTG(A/C/T)GAGCT | reference, synonymous-codon, stop-gained | |
| rs10534149 | -- | 1,607,473(+) | AAAGA(-/TAAT)TAATC | intron-variant | |
| rs10582998 | -- | 1,629,096(+) | TATAT(-/AT)GTGTG | intron-variant | |
| rs111161782 | -- | 1,596,662(+) | TGAGG(C/T)GGATT | intron-variant | |
| rs111161783 | -- | 1,596,666(+) | GTGGA(A/T)TCCTC | intron-variant |
Residual Variation Intolerance Score:
95.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.85;
83.59% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ASMT Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASMT Gene
Disorders for ASMT Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pineoblastoma |
|
|
| pineocytoma |
|
|
| pineal gland cancer |
|
|
| pineal parenchymal tumor of intermediate differentiation |
|
|
| branchiootic syndrome |
|
|
Search ASMT in MalaCards
View complete list of genes associated with diseases
Relevant External Links for ASMT
No data available for UniProtKB/Swiss-Prot and Genatlas for ASMT Gene
Publications for ASMT Gene
- Structural analysis of the human hydroxyindole-O-methyltransferase gene. Presence of two distinct promoters. (PMID: 7989373) Rodriguez I.R. … Chader G.J. (J. Biol. Chem. 1994) 2 3 4 22 64
- Human hydroxyindole-O-methyltransferase: presence of LINE-1 fragment in a cDNA clone and pineal mRNA. (PMID: 8397829) Donohue S.J. … Klein D.C. (DNA Cell Biol. 1993) 2 3 4 22 64
- Single-nucleotide polymorphisms and mRNA expression for melatonin synthesis rate-limiting enzyme in recurrent depressive disorder. (PMID: 20433639) GaA8ecki P. … Karbownik-LewiA8ska M. (J. Pineal Res. 2010) 3 22 46 64
- Sequencing ASMT identifies rare mutations in Chinese Han patients with autism. (PMID: 23349736) Wang L. … Zhang D. (PLoS ONE 2013) 3 4 64
- Genetic and functional abnormalities of the melatonin biosynthesis pathway in patients with bipolar disorder. (PMID: 22694957) Etain B. … Jamain S. (Hum. Mol. Genet. 2012) 3 4 64
Products for ASMT Gene
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- Browse R&D Systems for biochemical assays
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- Custom Assay Services
- OriGene Purified Proteins for ASMT
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- OriGene qPCR primer pairs and template standards for ASMT
- OriGene qPCR primer pairs for ASMT
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Browse GenScript CRISPR for ASMT
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- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for ASMT
- Novus Biologicals proteins and lysates for ASMT
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ProSpec Recombinant Proteins for ASMT
- antibodies-online Antibodies for ASMT: See all 40
- antibodies-online Kits for ASMT: See all 6
- antibodies-online Proteins for ASMT: See all 13
- Search antibodies-online for peptides
- GeneTex ASMT antibody for ASMT
- Search GeneTex for Proteins for ASMT
- ViGene Biosciences adenoviral particle packaged cDNA for ASMT gene
- ViGene Biosciences lentiviral particle packaged cDNA for ASMT gene
- ViGene Biosciences ready-to-package AAV shRNAs for ASMT gene
- Search ViGene Biosciences for ASMT
- Horizon Cell Lines for ASMT
- Cyagen custom Knockout/knockin (KOKI) mouse models for ASMT
- VectorBuilder custom plasmid, inducible vectors for ASMT
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ASMT
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ASMT Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
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