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ASMT Gene

protein-coding   GIFtS: 61
GCID: GC0XP001714

Acetylserotonin O-Methyltransferase

  See ASMT-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Acetylserotonin O-Methyltransferase1 2     HIOMTY2
Hydroxyindole O-Methyltransferase2 3     Acetylserotonin Methyltransferase (Y Chromosome)2
HIOMT2 3     Acetylserotonin N-Methyltransferase2
ASMTY2     EC 2.1.1.43

External Ids:    HGNC: 7501   Entrez Gene: 4382   Ensembl: ENSG000001964337   OMIM: 300015,4025005   UniProtKB: P465973   

Export aliases for ASMT gene to outside databases

Previous GC identifers: GC0XP001185 GC0XP001125 GC0XP001294 GC0XP001359 GC0XP001356 GC0YP001758 GC0XP001758 GC0XP001674


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ASMT Gene:
This gene belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the
end of the short arms of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the
synthesis of melatonin, and is abundant in the pineal gland. Alternatively spliced transcript variants have been
noted for this gene. (provided by RefSeq, Jan 2010)

GeneCards Summary for ASMT Gene:
ASMT (acetylserotonin O-methyltransferase) is a protein-coding gene. Diseases associated with ASMT include pineocytoma, and pineoblastoma. GO annotations related to this gene include O-methyltransferase activity and protein homodimerization activity. An important paralog of this gene is ASMTL.

UniProtKB/Swiss-Prot: ASMT_HUMAN, P46597
Function: Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin
(N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity

Gene Wiki entry for ASMT (Acetylserotonin O-methyltransferase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_000024.9  NC_018934.2  NT_167201.2  NT_187358.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the ASMT gene promoter:
         PPAR-alpha   p53   RelA   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidASMT promoter sequence
   Search Chromatin IP Primers for ASMT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ASMT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.3 or Yp11.3   Ensembl cytogenetic band:  Xp22.33   HGNC cytogenetic band: Xp22.3 and Yp11.3

ASMT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASMT gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP001714:  view genomic region     (about GC identifiers)

Start:
1,714,348 bp from pter      End:
1,761,974 bp from pter
Size:
47,627 bases      Orientation:
plus strand

1 alternative location:
ChrY+ 1,664,348-1,711,974     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ASMT_HUMAN, P46597 (See protein sequence)
Recommended Name: Acetylserotonin O-methyltransferase  
Size: 345 amino acids; 38453 Da
Subunit: Homodimer
Miscellaneous: The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y
chromosomes
2 PDB 3D structures from and Proteopedia for ASMT:
4A6D (3D)        4A6E (3D)    
Secondary accessions: B2RC33 Q16598 Q5JQ72 Q5JQ73
Alternative splicing: 3 isoforms:  P46597-1   P46597-2   P46597-3   (Includes part of a LINE-1 element. Ref.1 (AAA58582/AAA58583/AAA75290), Ref.2 (AAA17020) and Ref.3 (BAG37430) sequences are in conflict in position: 190:W->R)

Explore the universe of human proteins at neXtProt for ASMT: NX_P46597

Explore proteomics data for ASMT at MOPED


See ASMT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts): 
NP_001164509.1  NP_001164510.1  NP_004034.2  

ENSEMBL proteins: 
 ENSP00000370639   ENSP00000370627   ENSP00000370631   ENSP00000392053  
Reactome Protein details: P46597

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antibodies-online peptides for ASMT

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
PAR1: Pseudoautosomal regions / PAR1

4 InterPro protein domains:
 IPR025781 AS_MeTrfase
 IPR016461 COMT
 IPR011991 WHTH_DNA-bd_dom
 IPR001077 O_MeTrfase_2

Graphical View of Domain Structure for InterPro Entry P46597

ProtoNet protein and cluster: P46597

1 Blocks protein domain: IPB001077 O-methyltransferase

UniProtKB/Swiss-Prot: ASMT_HUMAN, P46597
Similarity: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent
O-methyltransferase family


Find genes that share domains with ASMT           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ASMT_HUMAN, P46597
Function: Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin
(N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity
Catalytic activity: S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin
Induction: By all-trans-, 9-cis- and 13-cis-retinoic acid and by serum treatment, following starvation, in the
retinoblastoma cell line Y79

     Genatlas biochemistry entry for ASMT:
methyltransferase,hydroxyindole-O,catalyzing the final step of melatonin synthesis,expressed in the pineal gland

     Enzyme Number (IUBMB): EC 2.1.1.41

     Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008168methyltransferase activity ----
GO:0008171O-methyltransferase activity TAS8397829
GO:0008757S-adenosylmethionine-dependent methyltransferase activity ----
GO:0017096acetylserotonin O-methyltransferase activity IDA--
GO:0042802identical protein binding IPI--
     
Find genes that share ontologies with ASMT           About GenesLikeMe


Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for ASMT

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol4
mitochondrion2
cytoskeleton1
extracellular1
nucleus1
peroxisome1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005829cytosol TAS--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for ASMT About   (see all 6)  
See pathways by source

SuperPathContained pathways About
1Tryptophan metabolism
Tryptophan metabolism0.46
Tryptophan metabolism0.46
2Metabolism
Metabolism0.38
Metabolic pathways0.38
3serotonin and melatonin biosynthesis
serotonin and melatonin biosynthesis
Serotonin and melatonin biosynthesis0.00
4Metabolism of amino acids and derivatives
Metabolism of amino acids and derivatives
Amine-derived hormones0.00
5tryptophan utilization II
tryptophan utilization I0.71


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Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


4 BioSystems Pathways for ASMT
    Biogenic Amine Synthesis
serotonin and melatonin biosynthesis
Tryptophan metabolism
tryptophan utilization I


1 Reactome Pathway for ASMT
    Serotonin and melatonin biosynthesis


2 Kegg Pathways  (Kegg details for ASMT):
    Tryptophan metabolism
Metabolic pathways

UniProtKB/Swiss-Prot: ASMT_HUMAN, P46597
Pathway: Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2

    Pathway & Disease-focused RT2 Profiler PCR Array including ASMT: 

          Drug Metabolism: Phase II Enzymes in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for ASMT

STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

Selected Interacting proteins for ASMT (P465971 ENSP000003706394) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
InteractantInteraction Details
GeneCardExternal ID(s)
ASMTP465971EBI-6502097,EBI-6502097
AANATENSP000002506154STRING: ENSP00000250615
ALDH1B1ENSP000003669274STRING: ENSP00000366927
ALDH2ENSP000002617334STRING: ENSP00000261733
ALDH3A2ENSP000003457744STRING: ENSP00000345774
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Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006412translation TAS8397829
GO:0030187melatonin biosynthetic process IEA--
GO:0034641cellular nitrogen compound metabolic process TAS--
GO:0044281small molecule metabolic process TAS--
GO:0046219indolalkylamine biosynthetic process TAS--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Enzo Life Sciences drugs & compounds for ASMT
  Browse compounds at ApexBio 

Browse Tocris compounds for ASMT

6 HMDB Compounds for ASMT    About this table
CompoundSynonyms CAS #PubMed Ids
Melatonin5-Methoxy-N-acetyltryptamine (see all 23)73-31-4180879
5-Hydroxyindoleacetic acid5-Hydroxy-1H-indole-3-acetate (see all 18)54-16-0--
5-Methoxyindoleacetate5-Methoxyindol-3-ylacetate (see all 8)608-07-1--
N-Acetylserotonin5-Hydroxy-N-acetyltryptamine (see all 5)1210-83-9--
S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--

1 DrugBank Compound for ASMT    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
MelatoninMEL (see all 4)73-31-4target--180879
enzymesubstrate180879 180879

7 Novoseek inferred chemical compound relationships for ASMT gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
arylalkylamine 90.6 8 10338362 (1), 16150106 (1), 20377855 (1), 10496148 (1) (see all 8)
melatonin 84.2 66 20377855 (3), 10801305 (3), 10338362 (2), 10496148 (2) (see all 31)
dbc-amp 43 9 10496148 (4), 2162375 (1)
cyclic amp 38.2 2 2054606 (1), 10496148 (1)
butyrate 31.9 10 10496148 (5), 2162375 (1)
5-hydroxytryptamine 25.1 1 14675129 (1)
oligonucleotide 6.09 2 8397829 (1)



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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ASMT gene (3 alternative transcripts): 
NM_001171038.1  NM_001171039.1  NM_004043.2  

Unigene Cluster for ASMT:

Acetylserotonin O-methyltransferase
Hs.522572  [show with all ESTs]
Unigene Representative Sequence: NR_027383
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000381241(uc004cqd.3 uc010ncy.3 uc004cqe.3) ENST00000381229
ENST00000381233 ENST00000509780 ENST00000432523
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  QuantiFast Probe-based Assays in human, mouse, rat ASMT

Additional mRNA sequence: 

AK308367.1 AK314922.1 AY037933.1 BC001620.1 BC015800.1 BC016935.1 BC028151.1 BC110496.1 
BC110497.1 L03426.1 M83779.1 M99578.1 NR_027383.1 U11090.1 U11091.1 

Selected DOTS entries (see all 30):

DT.100672944  DT.91867980  DT.100802797  DT.209941  DT.120653611  DT.121323179  DT.121323194  DT.75172484 
DT.100748362  DT.121323191  DT.75140614  DT.95122194  DT.100000439  DT.121323164  DT.120653594  DT.121323176 
DT.116247  DT.121323170  DT.121323173  DT.91733938  DT.91789023  DT.95290492  DT.120653545  DT.121166704 

Selected AceView cDNA sequences (see all 301):

AW978405 AI217889 AA975839 AI129402 BE646344 BM510017 BQ433141 NM_004043 
AI083532 U11090 BX105929 CR620922 AI189957 AL041971 AI885136 AI433949 
BQ930425 NM_005088 U11091 AI143357 AI810064 BE858964 AA768174 BC028151 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ASMT    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9
SP1:                                      -                       -     -                     
SP2:                                      -           -     -     -     -                     
SP3:                                            -     -     -                                 
SP4:                                                                                          


ECgene alternative splicing isoforms for ASMT

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ASMT expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
ASMT Expression
About this image

ASMT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ASMT Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.522572

UniProtKB/Swiss-Prot: ASMT_HUMAN, P46597
Tissue specificity: Expressed in the pineal gland (at protein level). In the retina, very low expression is found
at the mRNA level (PubMed:7989373), and not at the protein level (PubMed:8574683)

    Pathway & Disease-focused RT2 Profiler PCR Array including ASMT: 
          Drug Metabolism: Phase II Enzymes in human mouse rat

Primer
Products:
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OriGene qSTAR qPCR primer pairs in human, mouse for ASMT
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ASMT
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QuantiFast Probe-based Assays in human, mouse, rat ASMT
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASMT

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for ASMT gene from Selected species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves ASMT1 acetylserotonin O-methyltransferase 62.51(n)
57.1(a)
  396286  NM_205343.1  NP_990674.1 
lizard
(Anolis carolinensis)
Reptilia --
--
(see all 7)
Uncharacterized protein
(see all 7)
55(a)
47(a)
(see all 7)
many → 1
many → 1
(see all 7)
3(113364919-113384627)
2(41562071-41579120)
tropical clawed frog
(Xenopus tropicalis)
Amphibia Str.84922 Transcribed sequence with weak similarity to protein more 71(n)    CF591017.1 
zebrafish
(Danio rerio)
Actinopterygii asmt1 acetylserotonin O-methyltransferase 61.11(n)
51.82(a)
  100141344  NM_001114909.1  NP_001108381.1 
fruit fly
(Drosophila melanogaster)
Insecta CG95156
--
16(a)
1 → many
2L(8939780-8943264)
worm
(Caenorhabditis elegans)
Secernentea dod-186
Protein DOD-18 (dod-18) mRNA, complete cds
16(a)
1 → many
I(8019579-8020903) WBGene00008316
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes --
Putative protein of unknown function
11(a)
1 → many
XV(530429-531127) YOR111W
        Species with no ortholog for ASMT

ENSEMBL Gene Tree for ASMT (if available)
TreeFam Gene Tree for ASMT (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ASMT gene
ASMTL2  
1 SIMAP similar gene for ASMT using alignment to 2 protein entries:     ASMT_HUMAN (see all proteins):
ASMTL

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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ASMT (see all 23)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr X posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs2013161811,2,4
----see VAR_0691212 mis40--------
rs1173435701,2,4
----see VAR_0691132 mis40--------
rs1461216551,2,4
----see VAR_0691262 mis40--------
VAR_0691254
----see VAR_0691252 Y H mis40--------
rs1480361601,2,4
----see VAR_0691222 mis40--------
rs1219188261,2,4
----see VAR_0691242 mis40--------
rs1219188271,2,4
----see VAR_0691272 mis40--------
VAR_0691324
----see VAR_0691322 V M mis40--------
VAR_0691284
----see VAR_0691282 G A mis40--------
VAR_0691174
----see VAR_0691172 V I mis40--------

HapMap Linkage Disequilibrium report for ASMT (1714348 - 1761974 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for ASMT (see all 40):    About this table    
Variant IDTypeSubtypePubMed ID
esv2739759CNV Deletion23290073
esv1988316CNV Deletion18987734
esv2657890CNV Deletion23128226
esv2739752CNV Deletion23290073
esv2739747CNV Deletion23290073
esv2739741CNV Deletion23290073
esv2314773CNV Deletion18987734
dgv1364e201CNV Deletion23290073
esv2739750CNV Deletion23290073
nsv821241CNV Deletion20802225

Human Gene Mutation Database (HGMD): ASMT
Locus Specific Mutation Databases (LSDB): ASMT

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 300015,402500    OMIM disorders: --

3 diseases for ASMT:    
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pineocytoma    pineoblastoma    insomnia

1 disease from the University of Copenhagen DISEASES database for ASMT:
Pineoblastoma

Find genes that share disorders with ASMT           About GenesLikeMe

5 Novoseek inferred disease relationships for ASMT gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
pineocytoma 82.4 6 10831155 (4), 16825954 (1)
pineal tumors 79.6 2 10831155 (1)
pineoblastoma 79.2 6 10831155 (4), 16825954 (1)
retinoblastoma 58.6 5 10496148 (2), 8842389 (1), 2162375 (1), 8574683 (1)
tumors 0 6 10831155 (2), 20418777 (1)

Genetic Association Database (GAD): ASMT
Human Genome Epidemiology (HuGE) Navigator: ASMT (4 documents)

Export disorders for ASMT gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ASMT gene, integrated from 10 sources (see all 56):
(articles sorted by number of sources associating them with ASMT)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Human hydroxyindole-O-methyltransferase: presence of LINE-1 fragment in a cDNA clone and pineal mRNA. (PubMed id 8397829)1, 2, 3, 9 Donohue S.J.... Klein D.C. (DNA Cell Biol. 1993)
  2. Structural analysis of the human hydroxyindole-O-methyltransferase gene. Presence of two distinct promoters. (PubMed id 7989373)1, 2, 3, 9 Rodriguez I.R.... Chader G.J. (J. Biol. Chem. 1994)
  3. Single-nucleotide polymorphisms and mRNA expression for melatonin synthesis rate-limiting enzyme in recurrent depressive disorder. (PubMed id 20433639)1, 4, 9 GaA8ecki P....Karbownik-LewiA8ska M. (J. Pineal Res. 2010)
  4. Sequencing ASMT identifies rare mutations in Chinese Han patients with autism. (PubMed id 23349736)1, 2 Wang L.... Zhang D. (PLoS ONE 2013)
  5. Genetic and functional abnormalities of the melatonin biosynthesis pathway in patients with bipolar disorder. (PubMed id 22694957)1, 2 Etain B.... Jamain S. (Hum. Mol. Genet. 2012)
  6. Mutation screening of ASMT, the last enzyme of the melatonin pathway, in a large sample of patients with intellectual disability. (PubMed id 21251267)1, 2 Pagan C.... Bourgeron T. (BMC Med. Genet. 2011)
  7. Genetic variations of the melatonin pathway in patients with attention-deficit and hyperactivity disorders. (PubMed id 21615493)1, 2 Chaste P.... Bourgeron T. (J. Pineal Res. 2011)
  8. Linkage and candidate gene studies of autism spectrum disorders in European populations. (PubMed id 20442744)1, 4 Holt R....Monaco A.P. (Eur. J. Hum. Genet. 2010)
  9. Abnormal melatonin synthesis in autism spectrum disorders. (PubMed id 17505466)1, 2 Melke J.... Bourgeron T. (Mol. Psychiatry 2008)
  10. Is ASMT a susceptibility gene for autism spectrum disorders? A replication study in European populations. (PubMed id 17957233)1, 2 Toma C.... Maestrini E. (Mol. Psychiatry 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 438 HGNC: 750 AceView: ASMT.1 Ensembl:ENSG00000196433 euGenes: HUgn438
ECgene: ASMT Kegg: 438 H-InvDB: ASMT

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ASMT Pharmacogenomics, SNPs, Pathways
Wikipedia http://en.wikipedia.org/wiki/5-hydroxyindole-O-methyltransferase

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ASMT gene:
Search GeneIP for patents involving ASMT

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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