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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ASMT Gene

protein-coding   GIFtS: 62
GCID: GC0XP001674

Acetylserotonin O-Methyltransferase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Acetylserotonin O-Methyltransferase1 2     HIOMTY2
HIOMT2 3 5     Acetylserotonin Methyltransferase (Y Chromosome)2
Hydroxyindole O-Methyltransferase2 3     Acetylserotonin N-Methyltransferase2
ASMTY2     EC 2.1.1.43

External Ids:    HGNC: 7501   Entrez Gene: 4382   Ensembl: ENSG000001964337   OMIM: 3000155   UniProtKB: P465973   

Export aliases for ASMT gene to outside databases

Previous GC identifers: GC0XP001185 GC0XP001125 GC0XP001294 GC0XP001359 GC0XP001356 GC0YP001758 GC0XP001758


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ASMT Gene:
This gene belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the
end of the short arms of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the
synthesis of melatonin, and is abundant in the pineal gland. Alternatively spliced transcript variants have been
noted for this gene. (provided by RefSeq, Jan 2010)

GeneCards Summary for ASMT Gene: 
ASMT (acetylserotonin O-methyltransferase) is a protein-coding gene. Diseases associated with ASMT include pineocytoma, and pineoblastoma, and among its related super-pathways are Amine-derived hormones and Tryptophan metabolism. GO annotations related to this gene include O-methyltransferase activity and protein homodimerization activity. An important paralog of this gene is ASMTL.

UniProtKB/Swiss-Prot: ASMT_HUMAN, P46597
Function: Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin
(N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity

Gene Wiki entry for ASMT (Acetylserotonin O-methyltransferase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_167196.1  NC_000024.9  NT_167204.1  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ASMT gene promoter:
         PPAR-alpha   p53   RelA   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidASMT promoter sequence
   Search SABiosciences Chromatin IP Primers for ASMT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASMT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.3 or Yp11.3   Ensembl cytogenetic band:  Xp22.33   HGNC cytogenetic band: Xp22.3 and Yp11.3

ASMT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASMT gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP001674:  view genomic region     (about GC identifiers)

Start:
1,714,348 bp from pter      End:
1,761,974 bp from pter
Size:
47,627 bases      Orientation:
plus strand

1 alternative location:
ChrY+ 1,664,348-1,711,974     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ASMT_HUMAN, P46597 (See protein sequence)
Recommended Name: Acetylserotonin O-methyltransferase  
Size: 345 amino acids; 38453 Da
Subunit: Homodimer
Miscellaneous: The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y
chromosomes
2 PDB 3D structures from and Proteopedia for ASMT:
4A6D (3D)        4A6E (3D)    
Secondary accessions: B2RC33 Q16598 Q5JQ72 Q5JQ73
Alternative splicing: 3 isoforms:  P46597-1   P46597-2   P46597-3   (Includes part of a LINE-1 element. Ref.1 (AAA58582/AAA58583/AAA75290), Ref.2 (AAA17020) and Ref.3 (BAG37430) sequences are in conflict in position: 190:W->R)

Explore the universe of human proteins at neXtProt for ASMT: NX_P46597

Explore proteomics data for ASMT at MOPED 

ASMT Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

ASMT Protein Expression

REFSEQ proteins (3 alternative transcripts): 
NP_001164509.1  NP_001164510.1  NP_004034.2  

ENSEMBL proteins: 
 ENSP00000370639   ENSP00000370627   ENSP00000370631   ENSP00000392053  
Reactome Protein details: P46597
Human Recombinant Protein Products for ASMT: 
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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005829cytosol TAS--

ASMT for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
PAR1: Pseudoautosomal regions / PAR1

4 InterPro protein domains:
 IPR011991 WHTH_DNA-bd_dom
 IPR001077 O_MeTrfase_2
 IPR025781 AS_MeTrfase
 IPR016461 COMT

Graphical View of Domain Structure for InterPro Entry P46597

ProtoNet protein and cluster: P46597

1 Blocks protein domain: IPB001077 O-methyltransferase

UniProtKB/Swiss-Prot: ASMT_HUMAN, P46597
Similarity: Belongs to the methyltransferase superfamily


ASMT for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: ASMT_HUMAN, P46597
Function: Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin
(N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity
Catalytic activity: S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin
Induction: By all-trans-, 9-cis- and 13-cis-retinoic acid and by serum treatment, following starvation, in the
retinoblastoma cell line Y79

     Genatlas biochemistry entry for ASMT:
methyltransferase,hydroxyindole-O,catalyzing the final step of melatonin synthesis,expressed in the pineal gland

     Enzyme Number (IUBMB): EC 2.1.1.41

     Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008168methyltransferase activity ----
GO:0008171O-methyltransferase activity TAS8397829
GO:0008757S-adenosylmethionine-dependent methyltransferase activity ----
GO:0017096acetylserotonin O-methyltransferase activity IDA--
GO:0042802identical protein binding IPI--
     
ASMT for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for ASMT About                                                                                                See pathways by source

SuperPathContained pathways About
1Regulation of thyroid hormone activity
Amine-derived hormones0.43
Serotonin and melatonin biosynthesis0.36
serotonin and melatonin biosynthesis0.36
Biogenic Amine Synthesis0.32
2Tryptophan metabolism
Tryptophan metabolism0.46
Tryptophan metabolism0.46
3Metabolism
Metabolism0.40
Metabolic pathways0.40
4tryptophan utilization II
tryptophan utilization I0.70
5Metabolism of amino acids and derivatives
Metabolism of amino acids and derivatives

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


4 BioSystems Pathways for ASMT
    Biogenic Amine Synthesis
serotonin and melatonin biosynthesis
Tryptophan metabolism
tryptophan utilization I


4        Reactome Pathways for ASMT
    Amine-derived hormones
Serotonin and melatonin biosynthesis
Metabolism
Metabolism of amino acids and derivatives


2         Kegg Pathways  (Kegg details for ASMT):
    Tryptophan metabolism
Metabolic pathways

UniProtKB/Swiss-Prot: ASMT_HUMAN, P46597
Pathway: Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2


ASMT for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ASMT

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

5/12 Interacting proteins for ASMT (P465971 ENSP000003706394) via UniProtKB, MINT, STRING, and/or I2D (see all 12)

InteractantInteraction Details
GeneCardExternal ID(s)
ASMTP465971EBI-6502097,EBI-6502097
AANATENSP000002506154STRING: ENSP00000250615
ALDH1B1ENSP000003669274STRING: ENSP00000366927
ALDH2ENSP000002617334STRING: ENSP00000261733
ALDH3A2ENSP000003457744STRING: ENSP00000345774
About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006412translation TAS8397829
GO:0030187melatonin biosynthetic process IEA--
GO:0034641cellular nitrogen compound metabolic process TAS--
GO:0044281small molecule metabolic process TAS--
GO:0046219indolalkylamine biosynthetic process TAS--

ASMT for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ASMT for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Enzo Life Sciences drugs & compounds for ASMT

Browse Tocris compounds for ASMT

6 HMDB Compounds for ASMT    About this table
CompoundSynonyms CAS #PubMed Ids
Melatonin5-Methoxy-N-acetyltryptamine (see all 23)73-31-4180879
5-Hydroxyindoleacetic acid5-Hydroxy-1H-indole-3-acetate (see all 18)54-16-0--
5-Methoxyindoleacetate5-Methoxyindol-3-ylacetate (see all 8)608-07-1--
N-Acetylserotonin5-Hydroxy-N-acetyltryptamine (see all 5)1210-83-9--
S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--

1 DrugBank Compound for ASMT    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
MelatoninMEL (see all 4)73-31-4target--180879
enzymesubstrate180879 180879

7 Novoseek inferred chemical compound relationships for ASMT gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
arylalkylamine 90.6 8 10338362 (1), 16150106 (1), 20377855 (1), 10496148 (1) (see all 8)
melatonin 84.2 66 20377855 (3), 10801305 (3), 10338362 (2), 10496148 (2) (see all 31)
dbc-amp 43 9 10496148 (4), 2162375 (1)
cyclic amp 38.2 2 2054606 (1), 10496148 (1)
butyrate 31.9 10 10496148 (5), 2162375 (1)
5-hydroxytryptamine 25.1 1 14675129 (1)
oligonucleotide 6.09 2 8397829 (1)

Search CenterWatch for drugs/clinical trials and news about ASMT

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ASMT gene (3 alternative transcripts): 
NM_001171038.1  NM_001171039.1  NM_004043.2  

Unigene Cluster for ASMT:

Acetylserotonin O-methyltransferase
Hs.522572  [show with all ESTs]
Unigene Representative Sequence: NR_027383
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000381241(uc004cqd.3 uc010ncy.3 uc004cqe.3) ENST00000381229
ENST00000381233 ENST00000432523
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Additional mRNA sequence: 

AK308367.1 AK314922.1 AY037933.1 BC001620.1 BC015800.1 BC016935.1 BC028151.1 BC110496.1 
BC110497.1 L03426.1 M83779.1 M99578.1 NR_027383.1 U11090.1 U11091.1 

24/30 DOTS entries (see all 30):

DT.100672944  DT.91867980  DT.100802797  DT.209941  DT.120653611  DT.121323179  DT.121323194  DT.75172484 
DT.100748362  DT.121323191  DT.75140614  DT.95122194  DT.100000439  DT.121323164  DT.120653594  DT.121323176 
DT.116247  DT.121323170  DT.121323173  DT.91733938  DT.91789023  DT.95290492  DT.120653545  DT.121166704 

24/301 AceView cDNA sequences (see all 301):

AW978405 AI217889 AA975839 AI129402 BE646344 BM510017 BQ433141 NM_004043 
AI083532 U11090 BX105929 CR620922 AI189957 AL041971 AI885136 AI433949 
BQ930425 NM_005088 U11091 AI143357 AI810064 BE858964 AA768174 BC028151 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ASMT    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9
SP1:                                      -                       -     -                     
SP2:                                      -           -     -     -     -                     
SP3:                                            -     -     -                                 
SP4:                                                                                          


ECgene alternative splicing isoforms for ASMT

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ASMT expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
ASMT Expression
About this image


See ASMT Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ASMT

SOURCE GeneReport for Unigene cluster: Hs.522572

UniProtKB/Swiss-Prot: ASMT_HUMAN, P46597
Tissue specificity: Expressed in the pineal gland (at protein level). In the retina, very low expression is found
at the mRNA level (PubMed:7989373), and not at the protein level (PubMed:8574683)

    SABiosciences Expression via Pathway-Focused PCR Array including ASMT: 
          Drug Metabolism: Phase II Enzymes in human mouse rat

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In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASMT

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ASMT gene from 9/16 species (see all 16)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves ASMT1 acetylserotonin O-methyltransferase 62.51(n)
57.1(a)
  396286  NM_205343.1  NP_990674.1 
lizard
(Anolis carolinensis)
Reptilia ASMT6
--
(see all 7)
Uncharacterized protein
(see all 7)
55(a)
45(a)
(see all 7)
many → 1
many → 1
(see all 7)
3(113364919-113384627)
2(41562071-41579120)
tropical clawed frog
(Xenopus tropicalis)
Amphibia Str.84922 Transcribed sequence with weak similarity to protein more 71(n)    CF591017.1 
zebrafish
(Danio rerio)
Actinopterygii asmt1 acetylserotonin O-methyltransferase 61.11(n)
51.82(a)
  100141344  NM_001114909.1  NP_001108381.1 
fruit fly
(Drosophila melanogaster)
Insecta CG95156
--

possible ortholog
2L(8939780-8943264)
worm
(Caenorhabditis elegans)
Secernentea dod-186
Protein DOD-18
1(a)
possible ortholog
I(8019579-8020903)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YOR111W6
Putative protein of unknown function

1 → many
XV(530429-531127)
thale cress
(Arabidopsis thaliana)
eudicotyledons OMT11 Quercetin 3-O-methyltransferase 1 41.97(n)
28.52(a)
  835504  NM_124796.3  NP_200227.1 
rice
(Oryza sativa)
Liliopsida Os08g01575001 hypothetical protein 46.71(n)
28.4(a)
  4344702  NM_001067566.1  NP_001061031.1 
        Species with no ortholog for ASMT

ENSEMBL Gene Tree for ASMT (if available)
TreeFam Gene Tree for ASMT (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for ASMT gene
ASMTL2  
1 SIMAP similar gene for ASMT using alignment to 2 protein entries:     ASMT_HUMAN (see all proteins):
ASMTL

ASMT for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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10/23 SNPs in ASMT are shown (see all 23)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr X posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0691214
----see VAR_0691212 I M mis40--------
VAR_0691134
----see VAR_0691132 K E mis40--------
VAR_0691264
----see VAR_0691262 I M mis40--------
VAR_0691254
----see VAR_0691252 Y H mis40--------
VAR_0691224
----see VAR_0691222 T M mis40--------
VAR_0691244
----see VAR_0691242 P L mis40--------
VAR_0691274
----see VAR_0691272 C S mis40--------
VAR_0691324
----see VAR_0691322 V M mis40--------
VAR_0691284
----see VAR_0691282 G A mis40--------
VAR_0691174
----see VAR_0691172 V I mis40--------

HapMap Linkage Disequilibrium report for ASMT (1714348 - 1761974 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/40 variations for ASMT (see all 40):    About this table     
Variant IDTypeSubtypePubMed ID
esv2739759CNV Deletion23290073
esv1988316CNV Deletion18987734
esv2657890CNV Deletion23128226
esv2739752CNV Deletion23290073
esv2739747CNV Deletion23290073
esv2739741CNV Deletion23290073
esv2314773CNV Deletion18987734
dgv1364e201CNV Deletion23290073
esv2739750CNV Deletion23290073
nsv821241CNV Deletion20802225


Human Gene Mutation Database (HGMD): ASMT

Locus Specific Mutation Databases (LSDB): ASMT
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing ASMT
DNA2.0 Custom Variant and Variant Library Synthesis for ASMT

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 300015    OMIM disorders: --

12 diseases for ASMT:    About MalaCards
pineocytoma    pineoblastoma    intellectual disability    autism spectrum disorder
retinoblastoma    attention deficit hyperactivity disorder    glaucoma    tuberculosis
schizophrenia    bipolar disorder    cholangiocarcinoma    retinitis

1 disease from the University of Copenhagen DISEASES database for ASMT:
Pineoblastoma

ASMT for disorders           About GeneDecksing

5 Novoseek inferred disease relationships for ASMT gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
pineocytoma 82.4 6 10831155 (4), 16825954 (1)
pineal tumors 79.6 2 10831155 (1)
pineoblastoma 79.2 6 10831155 (4), 16825954 (1)
retinoblastoma 58.6 5 10496148 (2), 8842389 (1), 2162375 (1), 8574683 (1)
tumors 0 6 10831155 (2), 20418777 (1)

Genetic Association Database (GAD): ASMT
Human Genome Epidemiology (HuGE) Navigator: ASMT (4 documents)

Export disorders for ASMT gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ASMT gene, integrated from 9 sources (see all 56):
(articles sorted by number of sources associating them with ASMT)
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  1. Human hydroxyindole-O-methyltransferase: presence of LINE-1 fragment in a cDNA clone and pineal mRNA. (PubMed id 8397829)1, 2, 3, 9 Donohue S.J.... Klein D.C. (1993)
  2. Structural analysis of the human hydroxyindole-O-methyltransferase gene. Presence of two distinct promoters. (PubMed id 7989373)1, 2, 3, 9 Rodriguez I.R....Chader G.J. (1994)
  3. Single-nucleotide polymorphisms and mRNA expression f or melatonin synthesis rate-limiting enzyme in recurrent depressive disorder. (PubMed id 20433639)1, 4, 9 GaA8ecki P....Karbownik-LewiA8ska M. (2010)
  4. Sequencing ASMT identifies rare mutations in Chinese Han patients with autism. (PubMed id 23349736)1, 2 Wang L.... Zhang D. (2013)
  5. Genetic and functional abnormalities of the melatonin biosynthesis pathway in patients with bipolar disorder. (PubMed id 22694957)1, 2 Etain B.... Jamain S. (2012)
  6. Mutation screening of ASMT, the last enzyme of the me latonin pathway, in a large sample of patients with intellectual disability. (PubMed id 21251267)1, 2 Pagan C....Bourgeron T. (2011)
  7. Genetic variations of the melatonin pathway in patient s with attention-deficit and hyperactivity disorders. (PubMed id 21615493)1, 2 Chaste P....Bourgeron T. (2011)
  8. Linkage and candidate gene studies of autism spectrum disorders in European populations. (PubMed id 20442744)1, 4 Holt R....Monaco A.P. (2010)
  9. Abnormal melatonin synthesis in autism spectrum disorders. (PubMed id 17505466)1, 2 Melke J....Bourgeron T. (2008)
  10. Is ASMT a susceptibility gene for autism spectrum disorders? A replication study in European populations. (PubMed id 17957233)1, 2 Toma C....Maestrini E. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
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OMIM
NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 438 HGNC: 750 AceView: ASMT.1 Ensembl:ENSG00000196433 euGenes: HUgn438
ECgene: ASMT Kegg: 438 H-InvDB: ASMT

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ASMT Pharmacogenomics, SNPs, Pathways
Wikipedia http://en.wikipedia.org/wiki/5-hydroxyindole-O-methyltransferase

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ASMT gene:
Search GeneIP for patents involving ASMT

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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