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ASIP Gene

protein-coding   GIFtS: 56
GCID: GC20P032790

Agouti Signaling Protein

(Previous names: agouti (mouse)-signaling protein, agouti signaling protein,...)
(Previous symbol: AGTIL)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Agouti Signaling Protein1 2     Agouti Signaling Protein, Nonagouti Homolog (Mouse)1
AGTIL1 2 3 5     Nonagouti Homolog (Mouse)1
Agouti Switch Protein2 3     AGSW2
AGTI2 3     Agouti Signaling Protein, Nonagouti Homolog2
ASP2 3     Agouti-Signaling Protein2
SHEP92 5     Nonagouti Homolog2
Agouti (Mouse)-Signaling Protein1     

External Ids:    HGNC: 7451   Entrez Gene: 4342   Ensembl: ENSG000001014407   OMIM: 6002015   UniProtKB: P421273   

Export aliases for ASIP gene to outside databases

Previous GC identifers: GC20P032606 GC20P033516 GC20P033563 GC20P032312 GC20P032848 GC20P029629 GC20P032783 GC20P032785


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ASIP Gene:
In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to
synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects
of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and
premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1)
affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating
hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in
regulating lipid metabolism in adipocytes. (provided by RefSeq, Jul 2008)

GeneCards Summary for ASIP Gene:
ASIP (agouti signaling protein) is a protein-coding gene. Diseases associated with ASIP include familial melanoma, and cutaneous malignant melanoma. GO annotations related to this gene include type 4 melanocortin receptor binding and receptor binding.

UniProtKB/Swiss-Prot: ASIP_HUMAN, P42127
Function: Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated
signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black
pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect
the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine
aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ASIP gene promoter:
         AML1a   NF-E2 p45   E47   CREB   POU2F1   POU2F1a   deltaCREB   Zic3   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidASIP promoter sequence
   Search Chromatin IP Primers for ASIP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ASIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.2-q12   Ensembl cytogenetic band:  20q11.22   HGNC cytogenetic band: 20q11.2-q12

ASIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASIP gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P032790:  view genomic region     (about GC identifiers)

Start:
32,782,375 bp from pter      End:
32,857,150 bp from pter
Size:
74,776 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ASIP_HUMAN, P42127 (See protein sequence)
Recommended Name: Agouti-signaling protein precursor  
Size: 132 amino acids; 14515 Da
5 PDB 3D structures from and Proteopedia for ASIP:
1Y7J (3D)        1Y7K (3D)        2IQW (3D)        2KZA (3D)        2L1J (3D)    
Secondary accessions: Q3SXL2

Explore the universe of human proteins at neXtProt for ASIP: NX_P42127

Explore proteomics data for ASIP at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn39

  • See ASIP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001663.2  
    ENSEMBL proteins: 
     ENSP00000454804   ENSP00000364092  

    ASIP Human Recombinant Protein Products:

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    Novus Biologicals ASIP Protein
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    Cloud-Clone Corp. Proteins for ASIP

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    ASIP Assay Products:

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    Cloud-Clone Corp. CLIAs for ASIP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR027300 Agouti_dom
     IPR007733 Agouti

    Graphical View of Domain Structure for InterPro Entry P42127

    ProtoNet protein and cluster: P42127

    1 Blocks protein domain: IPB007733 Agouti

    UniProtKB/Swiss-Prot: ASIP_HUMAN, P42127
    Domain: The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin
    Similarity: Contains 1 agouti domain


    ASIP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ASIP_HUMAN, P42127
    Function: Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated
    signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black
    pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect
    the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine
    aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes

         Genatlas biochemistry entry for ASIP:
    murine agouti (A) signaling protein,homolog,also antagonizing MC4R,predominantly expressed in
    skin,testis,ovary,heart,melanocortin receptor (MC1R) antagonist

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS7757071
    GO:0005515protein binding ----
    GO:0031779melanocortin receptor binding ----
    GO:0031781type 3 melanocortin receptor binding IEA--
    GO:0031782type 4 melanocortin receptor binding IEA--
         
    ASIP for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ASIP:
     Increased HPV18 LCR reporter a 

         Selected MGI mutant phenotypes (inferred from 85 alleles(MGI details for a) (see all 24):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     embryogenesis  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  integument  limbs/digits/tail  liver/biliary system 

    ASIP for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ASIP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ASIP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ASIP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ASIP

    miRNA
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    miRTarBase miRNAs that target ASIP:
    hsa-mir-335-5p (MIRT016804)

    Block miRNA regulation of human, mouse, rat ASIP using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmidASIP 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ASIP
    Predesigned siRNA for gene silencing in human, mouse, rat ASIP

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for ASIP

    Clone
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    GenScript: all cDNA clones in your preferred vector: ASIP (NM_001672)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ASIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASIP

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for ASIP
    Browse ESI BIO Cell Lines and PureStem Progenitors for ASIP 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASIP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ASIP_HUMAN, P42127: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space TAS7937887

    ASIP for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ASIP About    
    See pathways by source

    SuperPathContained pathways About
    1Basal cell carcinoma
    Melanogenesis0.32
    2Insulin-mediated glucose transport
    Insulin-mediated glucose transport
    3Adipogenesis
    Adipogenesis
    4Adenylate cyclase activating neuropeptides
    Adenylate cyclase activating neuropeptides

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for ASIP
        Adipogenesis
    Insulin-mediated glucose transport


    1 Kegg Pathway  (Kegg details for ASIP):
        Melanogenesis


    ASIP for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ASIP
    Interactions:

        GeneGlobe Interaction Network for ASIP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for ASIP (P421273 ENSP000003640924) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MC3RP419683, ENSP000002439114I2D: score=1 STRING: ENSP00000243911
    MC4RP322453, ENSP000002997664I2D: score=1 STRING: ENSP00000299766
    MC5RP330323, ENSP000003180774I2D: score=1 STRING: ENSP00000318077
    MC2RQ017183, ENSP000003338214I2D: score=1 STRING: ENSP00000333821
    MC1RQ017263I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006091generation of precursor metabolites and energy IEA--
    GO:0007165signal transduction TAS7757071
    GO:0007267cell-cell signaling TAS7757071
    GO:0008343adult feeding behavior IEA--
    GO:0009755hormone-mediated signaling pathway IEA--

    ASIP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ASIP

    1 HMDB Compound for ASIP    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    6 Novoseek inferred chemical compound relationships for ASIP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    eumelanin 89.2 4 16914083 (2), 16005546 (1), 11041354 (1)
    alpha msh 79.1 3 16081629 (1), 16914083 (1), 15748644 (1)
    phaeomelanin 76.7 2 15726415 (1)
    acth 46.6 5 9058374 (2), 15748644 (1), 12851336 (1)
    forskolin 11.6 1 9182807 (1)
    lipid 0 2 11395927 (1)



    ASIP for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ASIP gene: 
    NM_001672.2  

    Unigene Cluster for ASIP:

    Agouti signaling protein
    Hs.659995  [show with all ESTs]
    Unigene Representative Sequence: NM_001672
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000568305 ENST00000374954(uc002xah.1)
    miRNA
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    Block miRNA regulation of human, mouse, rat ASIP using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmidASIP 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ASIP
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ASIP (NM_001672)
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ASIP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ASIP
      QuantiTect SYBR Green Assays in human, mouse, rat ASIP
      QuantiFast Probe-based Assays in human, mouse, rat ASIP

    Additional mRNA sequence: 

    AY805391.1 BC104238.1 BC104239.2 

    1 DOTS entry:

    DT.405132 

    8 AceView cDNA sequences:

    AW206665 BX280085 NM_001672 AI220203 W02039 AI378919 W32238 AI698587 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ASIP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ASIP Expression
    About this image


    ASIP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
     
     Ovary (Reproductive System)
     
     Pancreas (Endocrine System)
    ASIP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ASIP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.659995

    UniProtKB/Swiss-Prot: ASIP_HUMAN, P42127
    Tissue specificity: Expressed in adipose tissue, testis, ovary and heart and at lower levels in liver, kidney and
    foreskin

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASIP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ASIP gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia a1 , 5 nonagouti1, 5 84.62(n)1
    80.77(a)1
      2 (76.83 cM)5
    505181  NM_015770.31  NP_056585.21 
     1547914025 
    chicken
    (Gallus gallus)
    Aves ASIP6
    Gallus gallus agouti signaling protein (ASIP), mRN...
    40(a)
    1 ↔ 1
    20(1874674-1904718)
    zebrafish
    (Danio rerio)
    Actinopterygii asip6
    agouti signaling protein
    33(a)
    1 ↔ 1
    6(49927576-49934995) ENSDARG00000077858


    ENSEMBL Gene Tree for ASIP (if available)
    TreeFam Gene Tree for ASIP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    ASIP_HUMAN, P42127: Genetic variants in ASIP define the skin/hair/eye pigmentation variation locus 9 (SHEP9)
    [MIM:611742]. Hair, eye and skin pigmentation are among the most visible examples of human phenotypic variation,
    with a broad normal range that is subject to substantial geographic stratification. In the case of skin,
    individuals tend to have lighter pigmentation with increasing distance from the equator. By contrast, the
    majority of variation in human eye and hair color is found among individuals of European ancestry, with most
    other human populations fixed for brown eyes and black hair


    Selected SNPs for ASIP (see all 256)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs342595901,2
    C--29637558(+) ATTTA-/CT    
       T
    /TTC
    TTTTT
    2 -- cds10--------
    rs1405985571,2
    C--29638366(+) CAAAC-/AAAAAA 1 -- int10--------
    rs114713041,2
    C--32846502(+) ATATA-/C/    
       CATAC
    TATAT
    1 -- us2k10--------
    rs754853141,2
    C--32849879(+) AATGTA/TTGTAT 1 -- us2k10--------
    rs767957271,2
    C--32849880(+) ATGTTG/TGTATA 1 -- us2k10--------
    rs711928011,2
    C--32850068(-) AGTAT-/GT/TATATATATA
    TATATATATATATATA
    ATATA
    1 -- us2k11NA 2
    rs556693571,2
    --32850069(+) ATATAC/TATACT 1 -- us2k10--------
    rs752508381,2
    C--32850096(+) TATATA/GTTATA 1 -- us2k10--------
    rs785326981,2
    C--32850101(+) ATTATA/GAAATA 1 -- us2k10--------
    rs722800511,2
    C--32850133(+) ATATA-/ATATATG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ASIP (32782375 - 32857150 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ASIP: --
    Human Gene Mutation Database (HGMD): ASIP
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ASIP
    DNA2.0 Custom Variant and Variant Library Synthesis for ASIP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600201   
    OMIM disorders: 611742  
    15 diseases for ASIP:    
    About MalaCards
    familial melanoma    cutaneous malignant melanoma    autoimmune hepatitis    hemoglobinopathy
    infertility    obesity    vitiligo    basal cell carcinoma
    melanoma    diabetes mellitus    hepatocellular carcinoma    hepatitis
    breast cancer    pancreatitis    neuronitis


    ASIP for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for ASIP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 53.2 22 15998953 (4), 12519127 (3), 19384953 (2), 11833005 (2) (see all 7)
    skin cancer 45.6 1 19384953 (1)
    obesity 26.1 6 10509601 (2), 10078851 (2), 9326333 (1)
    niddm 0.93 2 7757071 (1)
    necrosis 0 1 9326333 (1)

    Genetic Association Database (GAD): ASIP
    Human Genome Epidemiology (HuGE) Navigator: ASIP (29 documents)

    Export disorders for ASIP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ASIP gene, integrated from 10 sources (see all 88):
    (articles sorted by number of sources associating them with ASIP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A polymorphism in the agouti signaling protein gene is associated with human pigmentation. (PubMed id 11833005)1, 2, 4, 9 Kanetsky P.A....Rebbeck T.R. (Am. J. Hum. Genet. 2002)
    2. Structure and function of ASP, the human homolog of the mouse agouti gene. (PubMed id 7757071)1, 2, 3, 9 Wilson B.D.... Barsh G.S. (Hum. Mol. Genet. 1995)
    3. Molecular structure and chromosomal mapping of the human homolog of the agouti gene. (PubMed id 7937887)1, 2, 3 Kwon H.-Y.... Woychik R.P. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    4. The 8818G allele of the agouti signaling protein (ASIP) gene is ancestral and is associated with darker skin color in African Americans. (PubMed id 15726415)1, 4, 9 Bonilla C....Kittles R.A. (Hum. Genet. 2005)
    5. A polymorphism in the agouti signalling protein (ASIP) is associated with decreased levels of mRNA. (PubMed id 16704456)1, 4, 9 Voisey J....van Daal A. (Pigment Cell Res. 2006)
    6. Population differences in the frequency of the agouti signaling protein g.8818a&gt;G polymorphism. (PubMed id 15016309)1, 4, 9 Zeigler-Johnson C....Kanetsky P.A. (Pigment Cell Res. 2004)
    7. The contribution of melanocortin 1 receptor gene polymorphisms and the agouti signalling protein gene 8818A&gt;G polymorphism to cutaneous melanoma and basal cell carcinoma in a Polish population. (PubMed id 18637131)1, 4, 9 Brudnik U....Kanas P. (Exp. Dermatol. 2009)
    8. Multiple pigmentation gene polymorphisms account for a substantial proportion of risk of cutaneous malignant melanoma. (PubMed id 19710684)1, 4, 9 Duffy D.L....Montgomery G.W. (J. Invest. Dermatol. 2010)
    9. Genetic variants in pigmentation genes, pigmentary phenotypes, and risk of skin cancer in Caucasians. (PubMed id 19384953)1, 4, 9 Nan H....Han J. (Int. J. Cancer 2009)
    10. Two newly identified genetic determinants of pigmentation in Europeans. (PubMed id 18488028)1, 4, 9 Sulem P.... Stefansson K. (Nat. Genet. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Disorders
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 434 HGNC: 745 AceView: ASIP Ensembl:ENSG00000101440 euGenes: HUgn434
    ECgene: ASIP Kegg: 434 H-InvDB: ASIP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ASIP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ASIP Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ASIP gene:
    Search GeneIP for patents involving ASIP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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