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Aliases for ASIC5 Gene

Aliases for ASIC5 Gene

  • Acid Sensing (Proton Gated) Ion Channel Family Member 5 2 3
  • Acid-Sensing (Proton-Gated) Ion Channel Family Member 5 2 3
  • Amiloride-Sensitive Cation Channel 5, Intestinal 2 3
  • Human Intestine Na(+) Channel 3 4
  • ACCN5 3 4
  • HINAC 3 4
  • Amiloride-Sensitive Cation Channel 5 4
  • Amiloride-Sensitive Sodium Channel 3
  • Acid-Sensing Ion Channel 5 3
  • INAC 3

External Ids for ASIC5 Gene

Previous HGNC Symbols for ASIC5 Gene

  • ACCN5

Previous GeneCards Identifiers for ASIC5 Gene

  • GC04M156751

Summaries for ASIC5 Gene

Entrez Gene Summary for ASIC5 Gene

  • This gene belongs to the amiloride-sensitive Na+ channel and degenerin (NaC/DEG) family, members of which have been identified in many animal species ranging from the nematode to human. The amiloride-sensitive Na(+) channel encoded by this gene is primarily expressed in the small intestine, however, its exact function is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for ASIC5 Gene

ASIC5 (Acid Sensing (Proton Gated) Ion Channel Family Member 5) is a Protein Coding gene. Diseases associated with ASIC5 include hypoaldosteronism. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include ligand-gated sodium channel activity and hydrogen ion channel activity. An important paralog of this gene is SCNN1G.

UniProtKB/Swiss-Prot for ASIC5 Gene

  • Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASIC5 Gene

Genomics for ASIC5 Gene

Genomic Location for ASIC5 Gene

Start:
155,829,729 bp from pter
End:
155,866,273 bp from pter
Size:
36,545 bases
Orientation:
Minus strand

Genomic View for ASIC5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ASIC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASIC5 Gene

No data available for Regulatory Elements for ASIC5 Gene

Proteins for ASIC5 Gene

  • Protein details for ASIC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NY37-ASIC5_HUMAN
    Recommended name:
    Acid-sensing ion channel 5
    Protein Accession:
    Q9NY37
    Secondary Accessions:

    Protein attributes for ASIC5 Gene

    Size:
    505 amino acids
    Molecular mass:
    57464 Da
    Quaternary structure:
    • Homotrimer or heterotrimer with other ASIC proteins.

neXtProt entry for ASIC5 Gene

Proteomics data for ASIC5 Gene at MOPED

Post-translational modifications for ASIC5 Gene

  • Glycosylation at Asn147 and Asn163
  • Modification sites at PhosphoSitePlus

Other Protein References for ASIC5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ASIC5 Gene

Domains for ASIC5 Gene

Protein Domains for ASIC5 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NY37

UniProtKB/Swiss-Prot:

ASIC5_HUMAN :
  • Q9NY37
Family:
  • Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC5 subfamily.
genes like me logo Genes that share domains with ASIC5: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for ASIC5 Gene

Function for ASIC5 Gene

Molecular function for ASIC5 Gene

UniProtKB/Swiss-Prot Function: Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride.

Gene Ontology (GO) - Molecular Function for ASIC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005272 sodium channel activity --
GO:0015252 hydrogen ion channel activity IEA --
GO:0015280 ligand-gated sodium channel activity IEA --
genes like me logo Genes that share ontologies with ASIC5: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ASIC5 Gene

Localization for ASIC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ASIC5 Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for ASIC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ASIC5: view

No data available for Subcellular locations from COMPARTMENTS for ASIC5 Gene

Pathways for ASIC5 Gene

genes like me logo Genes that share pathways with ASIC5: view

Pathways by source for ASIC5 Gene

Interacting Proteins for ASIC5 Gene

Gene Ontology (GO) - Biological Process for ASIC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006814 sodium ion transport --
GO:0015992 proton transport IEA --
GO:0034220 ion transmembrane transport TAS --
GO:0035725 sodium ion transmembrane transport IEA --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with ASIC5: view

Compounds for ASIC5 Gene

(8) Novoseek inferred chemical compound relationships for ASIC5 Gene

Compound -log(P) Hits PubMed IDs
amiloride 80.7 21
sodium 79.9 71
serine 12.1 2
nacl 9.6 2
cyclic amp 9.22 2
genes like me logo Genes that share compounds with ASIC5: view

Transcripts for ASIC5 Gene

mRNA/cDNA for ASIC5 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ASIC5 Gene

No ASD Table

Relevant External Links for ASIC5 Gene

GeneLoc Exon Structure for
ASIC5
ECgene alternative splicing isoforms for
ASIC5

Expression for ASIC5 Gene

mRNA expression in normal human tissues for ASIC5 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ASIC5 Gene

SOURCE GeneReport for Unigene cluster for ASIC5 Gene Hs.381349

mRNA Expression by UniProt/SwissProt for ASIC5 Gene

Q9NY37-ASIC5_HUMAN
Tissue specificity: Detected in small intestine, duodenum and jejunum. Detected at very low levels in testis and rectum.
genes like me logo Genes that share expressions with ASIC5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ASIC5 Gene

Orthologs for ASIC5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ASIC5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ASIC5 35
  • 99.54 (n)
  • 99.21 (a)
ASIC5 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ACCN5 35
  • 84.29 (n)
  • 81.71 (a)
ASIC5 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ASIC5 35
  • 87.33 (n)
  • 83.17 (a)
ASIC5 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Asic5 35
  • 80.93 (n)
  • 78.9 (a)
Asic5 16
Asic5 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ASIC5 36
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Asic5 35
  • 80.93 (n)
  • 78.9 (a)
chicken
(Gallus gallus)
Aves ASIC5 35
  • 68.4 (n)
  • 60.4 (a)
ASIC5 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ASIC5 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia asic5 35
  • 63.52 (n)
  • 58.2 (a)
worm
(Caenorhabditis elegans)
Secernentea acd-1 36
  • 17 (a)
OneToMany
acd-2 36
  • 15 (a)
OneToMany
acd-4 36
  • 15 (a)
OneToMany
acd-5 36
  • 14 (a)
OneToMany
delm-1 36
  • 17 (a)
OneToMany
delm-2 36
  • 17 (a)
OneToMany
flr-1 36
  • 15 (a)
OneToMany
Species with no ortholog for ASIC5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ASIC5 Gene

ENSEMBL:
Gene Tree for ASIC5 (if available)
TreeFam:
Gene Tree for ASIC5 (if available)

Paralogs for ASIC5 Gene

Paralogs for ASIC5 Gene

Selected SIMAP similar genes for ASIC5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ASIC5: view

Variants for ASIC5 Gene

Sequence variations from dbSNP and Humsavar for ASIC5 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs898362 -- 155,830,847(+) ACATT(A/G)TTAAT intron-variant
rs932081 -- 155,863,818(-) TTTAC(A/G)GATAG intron-variant
rs985335 -- 155,856,376(-) TGTGT(A/G)TGCCC intron-variant
rs1017728 -- 155,851,430(+) TTTTA(C/T)TTTTC intron-variant
rs1017729 -- 155,851,782(+) GATAT(A/G)CATTC intron-variant

Relevant External Links for ASIC5 Gene

HapMap Linkage Disequilibrium report
ASIC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ASIC5 Gene

Disorders for ASIC5 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ASIC5 Gene including...

Search for ASIC5 Gene in MalaCards »

(5) Novoseek inferred disease relationships for ASIC5 Gene

Disease -log(P) Hits PubMed IDs
liddles syndrome 82.2 1
pseudohypoaldosteronism 75.8 2
edema 23.4 1
cystic fibrosis 15.5 1
leukemia 0 1
genes like me logo Genes that share disorders with ASIC5: view

No data available for UniProtKB/Swiss-Prot for ASIC5 Gene

Publications for ASIC5 Gene

  1. Molecular cloning, functional expression and chromosomal localization of an amiloride-sensitive Na(+) channel from human small intestine. (PMID: 10767424) Schaefer L. … Lingueglia E. (FEBS Lett. 2000) 2 3 4
  2. Pharmacological and electrophysiological characterization of the human bile acid-sensitive ion channel (hBASIC). (PMID: 23842738) LefA"vre C.M. … Wiemuth D. (Pflugers Arch. 2014) 3
  3. Molecular characteristics of amiloride-sensitive sodium channels. (PMID: 1325667) Benos D.J. … Smith P.R. (Rev. Physiol. Biochem. Pharmacol. 1992) 23
  4. Effects of 5-hydroxytryptamine and 5-hydroxytryptamine receptor agonists on ion transport across mammalian airway epithelia. (PMID: 1327651) Graham A. … Geddes D.M. (Clin. Sci. 1992) 23
  5. Role of amiloride-sensitive sodium channels in taste. (PMID: 1369767) Avenet P. (Soc. Gen. Physiol. Ser. 1992) 23

Products for ASIC5 Gene

Sources for ASIC5 Gene

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