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Aliases for ASIC5 Gene

Aliases for ASIC5 Gene

  • Acid Sensing Ion Channel Subunit Family Member 5 2 3 5
  • Acid-Sensing (Proton-Gated) Ion Channel Family Member 5 2 3
  • Amiloride-Sensitive Cation Channel 5, Intestinal 2 3
  • Human Intestine Na(+) Channel 3 4
  • ACCN5 3 4
  • HINAC 3 4
  • Acid Sensing (Proton Gated) Ion Channel Family Member 5 3
  • Acid Sensing Ion Channel Family Member 5 3
  • Amiloride-Sensitive Cation Channel 5 4
  • Amiloride-Sensitive Sodium Channel 3
  • INAC 3

External Ids for ASIC5 Gene

Previous HGNC Symbols for ASIC5 Gene

  • ACCN5

Previous GeneCards Identifiers for ASIC5 Gene

  • GC04M156751

Summaries for ASIC5 Gene

Entrez Gene Summary for ASIC5 Gene

  • This gene belongs to the amiloride-sensitive Na+ channel and degenerin (NaC/DEG) family, members of which have been identified in many animal species ranging from the nematode to human. The amiloride-sensitive Na(+) channel encoded by this gene is primarily expressed in the small intestine, however, its exact function is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for ASIC5 Gene

ASIC5 (Acid Sensing Ion Channel Subunit Family Member 5) is a Protein Coding gene. Diseases associated with ASIC5 include liddle syndrome. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Development Endothelin-1/EDNRA signaling. GO annotations related to this gene include sodium channel activity and hydrogen ion channel activity. An important paralog of this gene is SCNN1G.

UniProtKB/Swiss-Prot for ASIC5 Gene

  • Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASIC5 Gene

Genomics for ASIC5 Gene

Genomic Location for ASIC5 Gene

155,829,729 bp from pter
155,866,273 bp from pter
36,545 bases
Minus strand

Genomic View for ASIC5 Gene

Genes around ASIC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASIC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASIC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASIC5 Gene

No data available for Regulatory Elements for ASIC5 Gene

Proteins for ASIC5 Gene

  • Protein details for ASIC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Acid-sensing ion channel 5
    Protein Accession:

    Protein attributes for ASIC5 Gene

    505 amino acids
    Molecular mass:
    57464 Da
    Quaternary structure:
    • Homotrimer or heterotrimer with other ASIC proteins.

neXtProt entry for ASIC5 Gene

Proteomics data for ASIC5 Gene at MOPED

Post-translational modifications for ASIC5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ASIC5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ASIC5 Gene

Domains & Families for ASIC5 Gene

Gene Families for ASIC5 Gene

Protein Domains for ASIC5 Gene

Suggested Antigen Peptide Sequences for ASIC5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC5 subfamily.
  • Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC5 subfamily.
genes like me logo Genes that share domains with ASIC5: view

Function for ASIC5 Gene

Molecular function for ASIC5 Gene

UniProtKB/Swiss-Prot Function:
Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride.

Gene Ontology (GO) - Molecular Function for ASIC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044736 acid-sensing ion channel activity TAS --
genes like me logo Genes that share ontologies with ASIC5: view

Phenotypes for ASIC5 Gene

genes like me logo Genes that share phenotypes with ASIC5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ASIC5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ASIC5 Gene

Localization for ASIC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ASIC5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ASIC5 Gene COMPARTMENTS Subcellular localization image for ASIC5 gene
Compartment Confidence
plasma membrane 4

No data available for Gene Ontology (GO) - Cellular Components for ASIC5 Gene

Pathways & Interactions for ASIC5 Gene

genes like me logo Genes that share pathways with ASIC5: view

Pathways by source for ASIC5 Gene

Interacting Proteins for ASIC5 Gene

Gene Ontology (GO) - Biological Process for ASIC5 Gene


No data available for SIGNOR curated interactions for ASIC5 Gene

Drugs & Compounds for ASIC5 Gene

(5) Drugs for ASIC5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for ASIC5 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Sodium
  • Sodium ion
genes like me logo Genes that share compounds with ASIC5: view

Transcripts for ASIC5 Gene

mRNA/cDNA for ASIC5 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ASIC5 Gene

No ASD Table

Relevant External Links for ASIC5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ASIC5 Gene

mRNA expression in normal human tissues for ASIC5 Gene

Protein differential expression in normal tissues from HIPED for ASIC5 Gene

This gene is overexpressed in Fetal gut (41.0) and Plasma (27.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ASIC5 Gene

SOURCE GeneReport for Unigene cluster for ASIC5 Gene Hs.381349

mRNA Expression by UniProt/SwissProt for ASIC5 Gene

Tissue specificity: Detected in small intestine, duodenum and jejunum. Detected at very low levels in testis and rectum.
genes like me logo Genes that share expression patterns with ASIC5: view

Protein tissue co-expression partners for ASIC5 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ASIC5 Gene

Orthologs for ASIC5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ASIC5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ACCN5 35
  • 84.29 (n)
  • 81.71 (a)
ASIC5 36
  • 81 (a)
(Canis familiaris)
Mammalia ASIC5 35
  • 87.33 (n)
  • 83.17 (a)
ASIC5 36
  • 83 (a)
(Mus musculus)
Mammalia Asic5 35
  • 80.93 (n)
  • 78.9 (a)
Asic5 16
Asic5 36
  • 79 (a)
(Pan troglodytes)
Mammalia ASIC5 35
  • 99.54 (n)
  • 99.21 (a)
ASIC5 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Asic5 35
  • 80.93 (n)
  • 78.9 (a)
(Ornithorhynchus anatinus)
Mammalia ASIC5 36
  • 49 (a)
(Gallus gallus)
Aves ASIC5 35
  • 68.4 (n)
  • 60.4 (a)
ASIC5 36
  • 61 (a)
(Anolis carolinensis)
Reptilia ASIC5 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia asic5 35
  • 63.52 (n)
  • 58.2 (a)
(Caenorhabditis elegans)
Secernentea acd-1 36
  • 17 (a)
acd-2 36
  • 15 (a)
acd-4 36
  • 15 (a)
acd-5 36
  • 14 (a)
delm-1 36
  • 17 (a)
delm-2 36
  • 17 (a)
flr-1 36
  • 15 (a)
Species with no ortholog for ASIC5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ASIC5 Gene

Gene Tree for ASIC5 (if available)
Gene Tree for ASIC5 (if available)

Paralogs for ASIC5 Gene

Paralogs for ASIC5 Gene

(2) SIMAP similar genes for ASIC5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ASIC5: view

Variants for ASIC5 Gene

Sequence variations from dbSNP and Humsavar for ASIC5 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs898362 -- 155,830,847(+) ACATT(A/G)TTAAT intron-variant
rs1968783 -- 155,833,814(+) TTGTC(C/T)AATCA intron-variant
rs4691944 -- 155,832,022(+) AATGT(C/T)AAACT intron-variant
rs6536098 -- 155,831,499(+) GGGCA(C/T)GGTGG intron-variant
rs6536099 -- 155,831,529(+) CACCT(C/T)AGGAG intron-variant

Variation tolerance for ASIC5 Gene

Residual Variation Intolerance Score: 63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.12; 38.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ASIC5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ASIC5 Gene

Disorders for ASIC5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ASIC5 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
liddle syndrome
  • liddle's syndrome
- elite association - COSMIC cancer census association via MalaCards
Search ASIC5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ASIC5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ASIC5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ASIC5 Gene

Publications for ASIC5 Gene

  1. Molecular cloning, functional expression and chromosomal localization of an amiloride-sensitive Na(+) channel from human small intestine. (PMID: 10767424) Schaefer L. … Lingueglia E. (FEBS Lett. 2000) 2 3 4 67
  2. Pharmacological and electrophysiological characterization of the human bile acid-sensitive ion channel (hBASIC). (PMID: 23842738) LefA"vre C.M. … Wiemuth D. (Pflugers Arch. 2014) 3
  3. Improving survival by increasing lung edema clearance: is airspace delivery of dopamine a solution? (PMID: 18439324) Jaitovich A. … Sznajder J.I. (Crit Care 2008) 23
  4. Distinct domain-dependent effect of syntaxin1A on amiloride-sensitive sodium channel (ENaC) currents in HT-29 colonic epithelial cells. (PMID: 17200691) Saxena S.K. … George C. (Int. J. Biol. Sci. 2007) 23
  5. Amiloride-sensitive sodium channels on the parietal human peritoneum: evidence by ussing-type chamber experiments. (PMID: 17515725) Stefanidis I. … Molyvdas P.A. (ASAIO J. 2007) 23

Products for ASIC5 Gene

Sources for ASIC5 Gene

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