Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ASIC5 Gene

protein-coding   GIFtS: 40
GCID: GC04M156751

Acid-Sensing (Proton-Gated) Ion Channel Family Member 5

(Previous names: amiloride-sensitive cation channel 5, intestinal)
(Previous symbol: ACCN5)
  See ASIC5-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Acid-Sensing (Proton-Gated) Ion Channel Family Member 51 2     INAC2
ACCN51 2 3     Acid-Sensing Ion Channel 52
Amiloride-Sensitive Cation Channel 5, Intestinal1 2     Amiloride-Sensitive Sodium Channel2
Human Intestine Na(+) Channel2 3     HINaC3
HINAC2 3     Amiloride-Sensitive Cation Channel 53

External Ids:    HGNC: 175371   Entrez Gene: 518022   Ensembl: ENSG000002563947   UniProtKB: Q9NY373   

Export aliases for ASIC5 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ASIC5 Gene:
This gene belongs to the amiloride-sensitive Na+ channel and degenerin (NaC/DEG) family, members of which have
been identified in many animal species ranging from the nematode to human. The amiloride-sensitive Na(+) channel
encoded by this gene is primarily expressed in the small intestine, however, its exact function is not known.
(provided by RefSeq, Jul 2008)

GeneCards Summary for ASIC5 Gene:
ASIC5 (acid-sensing (proton-gated) ion channel family member 5) is a protein-coding gene. Diseases associated with ASIC5 include hypoaldosteronism. GO annotations related to this gene include ligand-gated sodium channel activity and hydrogen ion channel activity. An important paralog of this gene is SCNN1B.

UniProtKB/Swiss-Prot: ASIC5_HUMAN, Q9NY37
Function: Cation channel that gives rise to very low constitutive currents in the absence of activation. The
activated channel exhibits selectivity for sodium, and is inhibited by amiloride




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ASIC5
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidASIC5 promoter sequence
   Search Chromatin IP Primers for ASIC5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ASIC5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q32.1   Ensembl cytogenetic band:  4q32.1   HGNC cytogenetic band: 4q32.1

ASIC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASIC5 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M156751:  view genomic region     (about GC identifiers)

Start:
156,750,881 bp from pter      End:
156,787,425 bp from pter
Size:
36,545 bases      Orientation:
minus strand

1 alternative location:
Chr4-,NW_003315914 1,271-30,896     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ASIC5_HUMAN, Q9NY37 (See protein sequence)
Recommended Name: Acid-sensing ion channel 5  
Size: 505 amino acids; 57464 Da
Subunit: Homotrimer or heterotrimer with other ASIC proteins (By similarity)

Explore the universe of human proteins at neXtProt for ASIC5: NX_Q9NY37

Explore proteomics data for ASIC5 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn147, Asn163
  • Modification sites at PhosphoSitePlus

  • See ASIC5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_059115.1  
    ENSEMBL proteins: 
     ENSP00000442477  
    Reactome Protein details: Q9NY37

    ASIC5 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ASIC5
    OriGene Protein Over-expression Lysate for ASIC5
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ASIC5
    GenScript Custom Purified and Recombinant Proteins Services for ASIC5
    Novus Biologicals ASIC5 Protein
    Novus Biologicals ASIC5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ASIC5 

     
    antibodies-online proteins for ASIC5 

     
    antibodies-online peptides for ASIC5

    ASIC5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ASIC5
    Novus Biologicals ASIC5 Antibodies
    Search for Antibodies for ASIC5 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for ASIC5
    antibodies-online antibodies for ASIC5 (29 products) 

    ASIC5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ASIC5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ASIC5
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for ASIC5 
    antibodies-online kits for ASIC5 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR001873 Na+channel_ASC

    Graphical View of Domain Structure for InterPro Entry Q9NY37

    ProtoNet protein and cluster: Q9NY37

    1 Blocks protein domain: IPB001873 Na+ channel

    UniProtKB/Swiss-Prot: ASIC5_HUMAN, Q9NY37
    Similarity: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC5 subfamily


    Find genes that share domains with ASIC5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ASIC5_HUMAN, Q9NY37
    Function: Cation channel that gives rise to very low constitutive currents in the absence of activation. The
    activated channel exhibits selectivity for sodium, and is inhibited by amiloride

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005272sodium channel activity ----
    GO:0015252hydrogen ion channel activity IEA--
    GO:0015280ligand-gated sodium channel activity IEA--
         
    Find genes that share ontologies with ASIC5           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ASIC5

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ASIC5 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ASIC5
    SwitchGear 3'UTR luciferase reporter plasmidASIC5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ASIC5
    Predesigned siRNA for gene silencing in human, mouse, rat ASIC5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ASIC5

    Clone
    Products:
         
    OriGene clones in human, mouse for ASIC5 (see all 5)
    OriGene ORF clones in mouse, rat for ASIC5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for ASIC5
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ASIC5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASIC5

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ASIC5
    Browse ESI BIO Cell Lines and PureStem Progenitors for ASIC5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASIC5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ASIC5_HUMAN, Q9NY37: Cell membrane; Multi-pass membrane protein

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with ASIC5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ASIC5 About    
    See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.58
    Stimuli-sensing channels0.58
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47
    3Development Endothelin 1 EDNRA signaling
    Inflammatory mediator regulation of TRP channels0.37


    Find genes that share SuperPaths with ASIC5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ASIC5
        Stimuli-sensing channels


    1 Kegg Pathway  (Kegg details for ASIC5):
        Inflammatory mediator regulation of TRP channels

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ASIC5
    Interactions:

        Search GeneGlobe Interaction Network for ASIC5

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006814sodium ion transport ----
    GO:0015992proton transport ----
    GO:0034220ion transmembrane transport TAS--
    GO:0035725sodium ion transmembrane transport ----
    GO:0055085transmembrane transport TAS--

    Find genes that share ontologies with ASIC5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ASIC5

    8 Novoseek inferred chemical compound relationships for ASIC5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    amiloride 80.7 26 8590216 (3), 8889475 (2), 11603791 (1), 17200691 (1) (see all 18)
    sodium 79.9 88 8989732 (3), 8027031 (3), 8590216 (3), 8889475 (2) (see all 62)
    serine 12.1 2 9335501 (1), 10770960 (1)
    nacl 9.6 2 2163058 (1), 11705806 (1)
    cyclic amp 9.22 2 8027031 (2)
    oxygen 0 1 12023897 (1)
    nitric oxide 0 1 9530173 (1)
    dopamine 0 3 16284210 (1), 16679376 (1), 18439324 (1)



    Find genes that share compounds with ASIC5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ASIC5 gene: 
    NM_017419.2  

    Unigene Cluster for ASIC5:

    Acid-sensing (proton-gated) ion channel family member 5
    Hs.381349
    Unigene Representative Sequence: NM_017419
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000537611(uc003ipe.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ASIC5 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ASIC5
    SwitchGear 3'UTR luciferase reporter plasmidASIC5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ASIC5
    Predesigned siRNA for gene silencing in human, mouse, rat ASIC5
    Clone
    Products:
         
    OriGene clones in human, mouse for ASIC5 (see all 5)
    OriGene ORF clones in mouse, rat for ASIC5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for ASIC5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ASIC5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASIC5
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ASIC5
    OriGene qSTAR qPCR primer pairs in human, mouse for ASIC5
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat ASIC5
      QuantiTect SYBR Green Assays in human, mouse, rat ASIC5
      QuantiFast Probe-based Assays in human, mouse, rat ASIC5

    Additional mRNA sequence: AJ252011.1 

    1 DOTS entry:

    DT.91944457 

    2 AceView cDNA sequences:

    AJ252011 NM_017419 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ASIC5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATACCTTCAG
    ASIC5 Expression
    About this image

    ASIC5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ASIC5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.381349

    UniProtKB/Swiss-Prot: ASIC5_HUMAN, Q9NY37
    Tissue specificity: Detected in small intestine, duodenum and jejunum. Detected at very low levels in testis and
    rectum

        Custom PCR Arrays for ASIC5
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ASIC5
    OriGene qSTAR qPCR primer pairs in human, mouse for ASIC5
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat ASIC5
    QuantiTect SYBR Green Assays in human, mouse, rat ASIC5
    QuantiFast Probe-based Assays in human, mouse, rat ASIC5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASIC5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for ASIC5 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Asic51 , 5 amiloride-sensitive cation channel 5, intestinal5
    acid-sensing (proton-gated) ion channel family member more1
    80.93(n)1
    78.9(a)1
      3 (35.97 cM)5
    581701  NM_021370.21  NP_067345.11 
     819822905 
    chicken
    (Gallus gallus)
    Aves ASIC51 acid-sensing (proton-gated) ion channel family member more 68.4(n)
    60.4(a)
      428723  XM_426281.3  XP_426281.2 
    lizard
    (Anolis carolinensis)
    Reptilia ASIC56
    acid-sensing (proton-gated) ion channel family mem...
    65(a)
    1 ↔ 1
    5(129480187-129492740)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia asic51 acid-sensing (proton-gated) ion channel family member more 63.52(n)
    58.2(a)
      100498195  XM_002933484.2  XP_002933530.2 
    worm
    (Caenorhabditis elegans)
    Secernentea delm-16
    delm-26
    (see all 7)
    Protein C24G7.1 (C24G7.1) mRNA, complete cds
    (see all 7)
    17(a)
    17(a)
    (see all 7)
    many → 1
    many → 1
    (see all 7)
    IV(9132548-9135477) WBGene00009073
    I(4109407-4112385) WBGene00016063


    ENSEMBL Gene Tree for ASIC5 (if available)
    TreeFam Gene Tree for ASIC5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ASIC5 gene
    SCNN1B2  ASIC32  SCNN1G2  SCNN1A2  ASIC42  SCNN1D2  ASIC22  ASIC12  
    2 SIMAP similar genes for ASIC5 using alignment to 1 protein entry:     ASIC5_HUMAN:
    ASIC2    ASIC1

    Find genes that share paralogs with ASIC5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ASIC5 (see all 930)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1886769811,2
    --152489315(+) CAGATA/TTAACT 1 -- ds50010--------
    rs1932716971,2
    --156750447(+) CCTCCA/GAAAGT 1 -- ds50010--------
    rs356537351,2
    C,F--156750561(+) CATTTC/ATTGAA 1 -- ds50014Minor allele frequency- A:0.06NA 126
    rs1418112571,2
    C--156750766(+) ATATA-/AT/TA 
            
    CACAT
    1 -- ds50010--------
    rs2000680041,2
    --156750780(+) TATAT-/ATATA 
     TATACAC
    ATATA
    1 -- ds50010--------
    rs76561291,2
    C--156750787(+) ATATAC/TACACA 1 -- ds50010--------
    rs1494896521,2
    --156750875(+) AAATAC/TATATG 1 -- ds50010--------
    rs1430088501,2
    --156750910(+) TTTATC/TGAACT 1 -- ut310--------
    rs568535861,2
    C,F--156750933(+) GAAAAG/CTGACG 1 -- ut312Minor allele frequency- C:0.09WA NA 238
    rs1165334951,2
    C,F--156750938(+) GTGACG/ATAACA 1 -- ut311Minor allele frequency- A:0.04NA 120

    HapMap Linkage Disequilibrium report for ASIC5 (156750881 - 156787425 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ASIC5: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing ASIC5
    DNA2.0 Custom Variant and Variant Library Synthesis for ASIC5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    1 disease for ASIC5:    
    About MalaCards
    hypoaldosteronism


    Find genes that share disorders with ASIC5           About GenesLikeMe

    5 Novoseek inferred disease relationships for ASIC5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    liddles syndrome 82.2 1 9244833 (1)
    pseudohypoaldosteronism 75.8 2 12483305 (1), 10404817 (1)
    edema 23.4 1 16222038 (1)
    cystic fibrosis 15.5 1 2227949 (1)
    leukemia 0 1 12933324 (1)


    Export disorders for ASIC5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ASIC5 gene, integrated from 10 sources (see all 64):
    (articles sorted by number of sources associating them with ASIC5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, functional expression and chromosomal localization of an amiloride-sensitive Na(+) channel from human small intestine. (PubMed id 10767424)1, 2, 3 Schaefer L.... Lingueglia E. (FEBS Lett. 2000)
    2. A novel variant of the beta-subunit of the amiloride-sensitive sodium channel in African Americans. (PubMed id 8989732)9 Su Y.R....Menon A.G. (J. Am. Soc. Nephrol. 1996)
    3. [Distribution of amiloride-sensitive sodium channel in epithelial tissue]. (PubMed id 8590216)9 Bonvalet J.P....Farman N. (C. R. Seances Soc. Biol. Fil. 1995)
    4. G-proteins modulate amiloride-sensitive sodium channels. (PubMed id 8027031)9 Bubien J.K....Warnock D.G. (J. Biol. Chem. 1994)
    5. Amiloride-sensitive sodium channels on the parietal human peritoneum: evidence by ussing-type chamber experiments. (PubMed id 17515725)9 Stefanidis I....Molyvdas P.A. (ASAIO J. 2007)
    6. The effect of bile acid on the activation of amiloride-sensitive sodium channels in frog skin. (PubMed id 8889475)9 Lima M.S....Ferreira K.T. (Exp. Physiol. 1996)
    7. Distinct domain-dependent effect of syntaxin1A on amiloride-sensitive sodium channel (ENaC) currents in HT-29 colonic epithelial cells. (PubMed id 17200691)9 Saxena S.K....George C. (Int. J. Biol. Sci. 2007)
    8. Dopamine activates amiloride-sensitive sodium channels in alveolar type I cells in lung slice preparations. (PubMed id 16679376)9 Helms M.N....Eaton D.C. (Am. J. Physiol. Lung Cell Mol. Physiol. 2006)
    9. Dopamine regulation of amiloride-sensitive sodium channels in lung cells. (PubMed id 16284210)9 Helms M.N....Jain L. (Am. J. Physiol. Lung Cell Mol. Physiol. 2006)
    10. Rab4 GTP/GDP modulates amiloride-sensitive sodium channel (ENaC) function in colonic epithelia. (PubMed id 16389071)9 Saxena S.K....George C. (Biochem. Biophys. Res. Commun. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 51802 HGNC: 17537 AceView: ACCN5 Ensembl:ENSG00000256394 euGenes: HUgn51802
    ECgene: ASIC5 Kegg: 51802 H-InvDB: ASIC5

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ASIC5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ASIC5 gene:
    Search GeneIP for patents involving ASIC5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ASIC5  
     OriGene qPCR primer pairs and template standards for ASIC5   OriGene Protein Over-expression Lysate for ASIC5  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ASIC5  
     OriGene qSTAR qPCR primer pairs in human, mouse for ASIC5   OriGene Purified Protein for ASIC5  
     OriGene ORF clones in mouse, rat for ASIC5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ASIC5   OriGene Custom Protein Services for ASIC5  

     
     
     Block miRNA regulation of human, mouse, rat ASIC5 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ASIC5
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ASIC5 Predesigned siRNA for gene silencing in human, mouse, rat ASIC5
     QuantiFast Probe-based Assays in human, mouse, rat ASIC5 QuantiTect SYBR Green Assays in human, mouse, rat ASIC5
     Custom PCR Arrays for ASIC5 Search Chromatin IP Primers for ASIC5
     Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat ASIC5 Search GeneGlobe Interaction Network for ASIC5
     Search Regulatory tfbs for ASIC5
     GenScript Custom Purified and Recombinant Proteins Services for ASIC5 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for ASIC5
     GenScript Custom Assay Services for ASIC5 GenScript Custom overexpressing Cell Line Services for ASIC5
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ASIC5
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ASIC5 antibodies
     ASIC5 proteins
     ASIC5 lysates
     Search for Antibodies for ASIC5 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for ASIC5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for ASIC5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASIC5
     SwitchGear 3'UTR luciferase reporter plasmids for ASIC5
     SwitchGear Promoter luciferase reporter plasmids for ASIC5
     Search ThermoFisher Antibodies for ASIC5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASIC5
     Browse compounds at ApexBio
     Search Addgene for plasmids for ASIC5
      Search eBioscience for proteins for ASIC5
      Search eBioscience for elisas for ASIC5
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for ASIC5
     antibodies-online antibodies for ASIC5 (29 products)
     antibodies-online kits for ASIC5 (6 products)
     antibodies-online peptides for ASIC5
     antibodies-online proteins for ASIC5
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ASIC5 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4