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Aliases for ASIC5 Gene

Aliases for ASIC5 Gene

  • Acid Sensing (Proton Gated) Ion Channel Family Member 5 2 3
  • Acid-Sensing (Proton-Gated) Ion Channel Family Member 5 2 3
  • Amiloride-Sensitive Cation Channel 5, Intestinal 2 3
  • Human Intestine Na(+) Channel 3 4
  • ACCN5 3 4
  • HINAC 3 4
  • Amiloride-Sensitive Cation Channel 5 4
  • Amiloride-Sensitive Sodium Channel 3
  • INAC 3

External Ids for ASIC5 Gene

Previous HGNC Symbols for ASIC5 Gene

  • ACCN5

Previous GeneCards Identifiers for ASIC5 Gene

  • GC04M156751

Summaries for ASIC5 Gene

Entrez Gene Summary for ASIC5 Gene

  • This gene belongs to the amiloride-sensitive Na+ channel and degenerin (NaC/DEG) family, members of which have been identified in many animal species ranging from the nematode to human. The amiloride-sensitive Na(+) channel encoded by this gene is primarily expressed in the small intestine, however, its exact function is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for ASIC5 Gene

ASIC5 (Acid Sensing (Proton Gated) Ion Channel Family Member 5) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Ion channel transport. GO annotations related to this gene include sodium channel activity and hydrogen ion channel activity. An important paralog of this gene is SCNN1G.

UniProtKB/Swiss-Prot for ASIC5 Gene

  • Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASIC5 Gene

Genomics for ASIC5 Gene

Genomic Location for ASIC5 Gene

Chromosome:
4
Start:
155,829,729 bp from pter
End:
155,866,273 bp from pter
Size:
36,545 bases
Orientation:
Minus strand

Genomic View for ASIC5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ASIC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASIC5 Gene

No data available for Regulatory Elements for ASIC5 Gene

Proteins for ASIC5 Gene

  • Protein details for ASIC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NY37-ASIC5_HUMAN
    Recommended name:
    Acid-sensing ion channel 5
    Protein Accession:
    Q9NY37

    Protein attributes for ASIC5 Gene

    Size:
    505 amino acids
    Molecular mass:
    57464 Da
    Quaternary structure:
    • Homotrimer or heterotrimer with other ASIC proteins.

neXtProt entry for ASIC5 Gene

Proteomics data for ASIC5 Gene at MOPED

Post-translational modifications for ASIC5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ASIC5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ASIC5 Gene

Domains & Families for ASIC5 Gene

Gene Families for ASIC5 Gene

Protein Domains for ASIC5 Gene

Suggested Antigen Peptide Sequences for ASIC5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NY37

UniProtKB/Swiss-Prot:

ASIC5_HUMAN :
  • Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC5 subfamily.
Family:
  • Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC5 subfamily.
genes like me logo Genes that share domains with ASIC5: view

Function for ASIC5 Gene

Molecular function for ASIC5 Gene

UniProtKB/Swiss-Prot Function:
Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride.

Gene Ontology (GO) - Molecular Function for ASIC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005272 sodium channel activity --
GO:0015252 hydrogen ion channel activity IEA --
GO:0015280 ligand-gated sodium channel activity IEA --
genes like me logo Genes that share ontologies with ASIC5: view

Phenotypes for ASIC5 Gene

GenomeRNAi human phenotypes for ASIC5:
genes like me logo Genes that share phenotypes with ASIC5: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ASIC5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ASIC5 Gene

Localization for ASIC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ASIC5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ASIC5 Gene COMPARTMENTS Subcellular localization image for ASIC5 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for ASIC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ASIC5: view

Pathways & Interactions for ASIC5 Gene

genes like me logo Genes that share pathways with ASIC5: view

Pathways by source for ASIC5 Gene

Interacting Proteins for ASIC5 Gene

Gene Ontology (GO) - Biological Process for ASIC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006814 sodium ion transport --
GO:0015992 proton transport IEA --
GO:0034220 ion transmembrane transport TAS --
GO:0035725 sodium ion transmembrane transport IEA --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with ASIC5: view

No data available for SIGNOR curated interactions for ASIC5 Gene

Drugs & Compounds for ASIC5 Gene

(5) Drugs for ASIC5 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amiloride Approved Pharma Channel blocker 45
Dopamine Approved Pharma Full agonist, Agonist 2814
Nitric Oxide Approved Pharma 540
cyclic amp Experimental Pharma 0
serine Nutra 420

(3) Additional Compounds for ASIC5 Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
NaCl
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
genes like me logo Genes that share compounds with ASIC5: view

Transcripts for ASIC5 Gene

mRNA/cDNA for ASIC5 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ASIC5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ASIC5 Gene

No ASD Table

Relevant External Links for ASIC5 Gene

GeneLoc Exon Structure for
ASIC5
ECgene alternative splicing isoforms for
ASIC5

Expression for ASIC5 Gene

mRNA expression in normal human tissues for ASIC5 Gene

Protein differential expression in normal tissues from HIPED for ASIC5 Gene

This gene is overexpressed in Fetal gut (41.0) and Plasma (27.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ASIC5 Gene



SOURCE GeneReport for Unigene cluster for ASIC5 Gene Hs.381349

mRNA Expression by UniProt/SwissProt for ASIC5 Gene

Q9NY37-ASIC5_HUMAN
Tissue specificity: Detected in small intestine, duodenum and jejunum. Detected at very low levels in testis and rectum.
genes like me logo Genes that share expression patterns with ASIC5: view

Protein tissue co-expression partners for ASIC5 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ASIC5 Gene

Orthologs for ASIC5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ASIC5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ACCN5 35
  • 84.29 (n)
  • 81.71 (a)
ASIC5 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ASIC5 35
  • 87.33 (n)
  • 83.17 (a)
ASIC5 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Asic5 35
  • 80.93 (n)
  • 78.9 (a)
Asic5 16
Asic5 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ASIC5 35
  • 99.54 (n)
  • 99.21 (a)
ASIC5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Asic5 35
  • 80.93 (n)
  • 78.9 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia ASIC5 36
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves ASIC5 35
  • 68.4 (n)
  • 60.4 (a)
ASIC5 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ASIC5 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia asic5 35
  • 63.52 (n)
  • 58.2 (a)
worm
(Caenorhabditis elegans)
Secernentea acd-1 36
  • 17 (a)
OneToMany
acd-2 36
  • 15 (a)
OneToMany
acd-4 36
  • 15 (a)
OneToMany
acd-5 36
  • 14 (a)
OneToMany
delm-1 36
  • 17 (a)
OneToMany
delm-2 36
  • 17 (a)
OneToMany
flr-1 36
  • 15 (a)
OneToMany
Species with no ortholog for ASIC5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ASIC5 Gene

ENSEMBL:
Gene Tree for ASIC5 (if available)
TreeFam:
Gene Tree for ASIC5 (if available)

Paralogs for ASIC5 Gene

Paralogs for ASIC5 Gene

(2) SIMAP similar genes for ASIC5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ASIC5: view

Variants for ASIC5 Gene

Variation tolerance for ASIC5 Gene

Residual Variation Intolerance Score: 63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.12; 38.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ASIC5 Gene

HapMap Linkage Disequilibrium report
ASIC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for ASIC5 Gene

Disorders for ASIC5 Gene

Relevant External Links for ASIC5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ASIC5
genes like me logo Genes that share disorders with ASIC5: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASIC5 Gene

Publications for ASIC5 Gene

  1. Improving survival by increasing lung edema clearance: is airspace delivery of dopamine a solution? (PMID: 18439324) Jaitovich A. … Sznajder J.I. (Crit Care 2008) 23 67
  2. Distinct domain-dependent effect of syntaxin1A on amiloride-sensitive sodium channel (ENaC) currents in HT-29 colonic epithelial cells. (PMID: 17200691) Saxena S.K. … George C. (Int. J. Biol. Sci. 2007) 23 67
  3. Amiloride-sensitive sodium channels on the parietal human peritoneum: evidence by ussing-type chamber experiments. (PMID: 17515725) Stefanidis I. … Molyvdas P.A. (ASAIO J. 2007) 23 67
  4. Rab4 GTP/GDP modulates amiloride-sensitive sodium channel (ENaC) function in colonic epithelia. (PMID: 16389071) Saxena S.K. … George C. (Biochem. Biophys. Res. Commun. 2006) 23 67
  5. Dopamine regulation of amiloride-sensitive sodium channels in lung cells. (PMID: 16284210) Helms M.N. … Jain L. (Am. J. Physiol. Lung Cell Mol. Physiol. 2006) 23 67

Products for ASIC5 Gene

Sources for ASIC5 Gene

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