Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ASIC4 Gene

Aliases for ASIC4 Gene

  • Acid Sensing (Proton Gated) Ion Channel Family Member 4 2 3
  • Amiloride-Sensitive Cation Channel 4, Pituitary 2 3 4
  • ACCN4 3 4 6
  • Amiloride-Sensitive Cation Channel Family Member 4, Pituitary 2 3
  • Acid-Sensing (Proton-Gated) Ion Channel Family Member 4 2 3
  • BNAC4 3 6
  • Amiloride-Sensitive Cation Channel 4 4
  • Acid-Sensing Ion Channel 4 3
  • Brain Sodium Channel 4 3

External Ids for ASIC4 Gene

Previous Symbols for ASIC4 Gene

  • ACCN4

Summaries for ASIC4 Gene

Entrez Gene Summary for ASIC4 Gene

  • This gene belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. These channels have been implicated in synaptic transmission, pain perception as well as mechanoperception. This gene is predominantly expressed in the pituitary gland, and was considered a candidate for paroxysmal dystonic choreoathetosis (PDC), a movement disorder, however, no correlation was found between mutations in this gene and PDC. [provided by RefSeq, Feb 2012]

GeneCards Summary for ASIC4 Gene

ASIC4 (Acid Sensing (Proton Gated) Ion Channel Family Member 4) is a Protein Coding gene. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include ion channel activity and sodium ion transmembrane transporter activity. An important paralog of this gene is SCNN1G.

UniProtKB/Swiss-Prot for ASIC4 Gene

  • Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity.

Gene Wiki entry for ASIC4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASIC4 Gene

Genomics for ASIC4 Gene

Genomic Location for ASIC4 Gene

Start:
219,514,170 bp from pter
End:
219,538,772 bp from pter
Size:
24,603 bases
Orientation:
Plus strand

Genomic View for ASIC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ASIC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASIC4 Gene

No data available for Regulatory Elements for ASIC4 Gene

Proteins for ASIC4 Gene

  • Protein details for ASIC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FT7-ASIC4_HUMAN
    Recommended name:
    Acid-sensing ion channel 4
    Protein Accession:
    Q96FT7
    Secondary Accessions:
    • Q53SB7
    • Q6GMS1
    • Q6PIN9
    • Q9NQA4

    Protein attributes for ASIC4 Gene

    Size:
    647 amino acids
    Molecular mass:
    70105 Da
    Quaternary structure:
    • Homotrimer or heterotrimer with other ASIC proteins.
    SequenceCaution:
    • Sequence=CAB93980.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAC51338.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ASIC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASIC4 Gene

Proteomics data for ASIC4 Gene at MOPED

Post-translational modifications for ASIC4 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn318, Asn370, and Asn484

Other Protein References for ASIC4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ASIC4 Gene

Domains for ASIC4 Gene

Gene Families for ASIC4 Gene

HGNC:
  • ASIC :Ion channels / Acid-sensing (proton-gated) ion channels

Protein Domains for ASIC4 Gene

UniProtKB/Swiss-Prot:

ASIC4_HUMAN
Family:
  • Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC4 subfamily.:
    • Q96FT7
genes like me logo Genes that share domains with ASIC4: view

Function for ASIC4 Gene

Molecular function for ASIC4 Gene

UniProtKB/Swiss-Prot Function: Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity.

Gene Ontology (GO) - Molecular Function for ASIC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity TAS 10852210
GO:0005272 sodium channel activity IEA --
GO:0015081 sodium ion transmembrane transporter activity TAS 10852210
genes like me logo Genes that share ontologies with ASIC4: view

miRNA for ASIC4 Gene

miRTarBase miRNAs that target ASIC4

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ASIC4 Gene

Localization for ASIC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ASIC4 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for ASIC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 10852210
GO:0016020 membrane --
genes like me logo Genes that share ontologies with ASIC4: view

Pathways for ASIC4 Gene

genes like me logo Genes that share pathways with ASIC4: view

Pathways by source for ASIC4 Gene

Interacting Proteins for ASIC4 Gene

Gene Ontology (GO) - Biological Process for ASIC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 10852210
GO:0006814 sodium ion transport --
GO:0034220 ion transmembrane transport TAS 10852210
GO:0035725 sodium ion transmembrane transport TAS 10852210
genes like me logo Genes that share ontologies with ASIC4: view

Transcripts for ASIC4 Gene

Unigene Clusters for ASIC4 Gene

Acid-sensing (proton-gated) ion channel family member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ASIC4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - - - -
SP2: - -
SP3: -
SP4: -

Relevant External Links for ASIC4 Gene

GeneLoc Exon Structure for
ASIC4
ECgene alternative splicing isoforms for
ASIC4

Expression for ASIC4 Gene

mRNA expression in normal human tissues for ASIC4 Gene

mRNA differential expression in normal tissues according to GTEx for ASIC4 Gene

This gene is overexpressed in Pituitary (20.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ASIC4 Gene

SOURCE GeneReport for Unigene cluster for ASIC4 Gene Hs.87469

mRNA Expression by UniProt/SwissProt for ASIC4 Gene

Q96FT7-ASIC4_HUMAN
Tissue specificity: Expressed in pituitary gland. Weakly expressed in brain, vestibular system and organ of Corti.
genes like me logo Genes that share expressions with ASIC4: view

Orthologs for ASIC4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ASIC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACCN4 36
  • 99.33 (n)
  • 99.07 (a)
ASIC4 37
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ASIC4 36
  • 91.61 (n)
  • 94.94 (a)
ASIC4 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ASIC4 36
  • 91.65 (n)
  • 95.08 (a)
ASIC4 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Asic4 36
  • 91.15 (n)
  • 97.69 (a)
Asic4 16
Asic4 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ASIC4 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ASIC4 37
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Asic4 36
  • 91.54 (n)
  • 97.12 (a)
chicken
(Gallus gallus)
Aves ASIC4 36
  • 68.61 (n)
  • 66.43 (a)
ASIC4 37
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ASIC4 37
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia asic4 36
  • 65.19 (n)
  • 66.58 (a)
zebrafish
(Danio rerio)
Actinopterygii asic4a 36
  • 65.89 (n)
  • 64.91 (a)
asic4a 37
  • 61 (a)
OneToMany
asic4b 37
  • 57 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-105 38
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 30 (a)
ManyToMany
-- 37
  • 24 (a)
ManyToMany
Species with no ortholog for ASIC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ASIC4 Gene

ENSEMBL:
Gene Tree for ASIC4 (if available)
TreeFam:
Gene Tree for ASIC4 (if available)

Paralogs for ASIC4 Gene

Paralogs for ASIC4 Gene

Selected SIMAP similar genes for ASIC4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ASIC4: view

Variants for ASIC4 Gene

Sequence variations from dbSNP and Humsavar for ASIC4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs746233 -- 219,519,404(+) TCTCC(A/G)TTACC intron-variant
rs746234 -- 219,519,692(+) AGCCA(C/T)ACGTG intron-variant
rs907676 -- 219,513,611(+) ACCCC(C/G)GAAGC upstream-variant-2KB
rs907681 -- 219,519,830(-) TGGCC(C/T)GACTT intron-variant
rs1077661 -- 219,538,228(+) GTCCA(C/T)ACCCC utr-variant-3-prime

Relevant External Links for ASIC4 Gene

HapMap Linkage Disequilibrium report
ASIC4

No data available for Structural Variations from Database of Genomic Variants (DGV) for ASIC4 Gene

Disorders for ASIC4 Gene

No disorders were found for ASIC4 Gene.

No data available for UniProtKB/Swiss-Prot for ASIC4 Gene

Publications for ASIC4 Gene

  1. A new member of acid-sensing ion channels from pituitary gland. (PMID: 10852210) Gruender S. … Ruppersberg J.P. (NeuroReport 2000) 2 3 4
  2. Acid-sensing ion channel (ASIC) 4 gene: physical mapping, genomic organisation, and evaluation as a candidate for paroxysmal dystonia. (PMID: 11571555) Gruender S. … Fink J.K. (Eur. J. Hum. Genet. 2001) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for ASIC4 Gene

Sources for ASIC4 Gene

Back to Top

Content