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ASIC4 Gene

protein-coding   GIFtS: 50
GCID: GC02P220378

Acid-Sensing (Proton-Gated) Ion Channel Family Member 4

(Previous names: amiloride-sensitive cation channel 4, pituitary, amiloride-sensitive...)
(Previous symbol: ACCN4)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Acid-Sensing (Proton-Gated) Ion Channel Family Member 41 2     BNAC42 5
ACCN41 2 3 5     Acid-Sensing Ion Channel 42
Amiloride-Sensitive Cation Channel 4, Pituitary1 2 3     Brain Sodium Channel 42
Amiloride-Sensitive Cation Channel Family Member 4, Pituitary1 2     Amiloride-Sensitive Cation Channel 43

External Ids:    HGNC: 212631   Entrez Gene: 555152   Ensembl: ENSG000000721827   OMIM: 6067155   UniProtKB: Q96FT73   

Export aliases for ASIC4 gene to outside databases

Previous GC identifers: GC02P218401 GC02P219100


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ASIC4 Gene:
This gene belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive
sodium channels. These channels have been implicated in synaptic transmission, pain perception as well as
mechanoperception. This gene is predominantly expressed in the pituitary gland, and was considered a candidate
for paroxysmal dystonic choreoathetosis (PDC), a movement disorder, however, no correlation was found between
mutations in this gene and PDC. (provided by RefSeq, Feb 2012)

GeneCards Summary for ASIC4 Gene:
ASIC4 (acid-sensing (proton-gated) ion channel family member 4) is a protein-coding gene. GO annotations related to this gene include ion channel activity and sodium ion transmembrane transporter activity. An important paralog of this gene is SCNN1B.

UniProtKB/Swiss-Prot: ASIC4_HUMAN, Q96FT7
Function: Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity

Gene Wiki entry for ASIC4 (ACCN4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ASIC4
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidASIC4 promoter sequence
   Search Chromatin IP Primers for ASIC4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ASIC4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q36.1

ASIC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASIC4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P220378:  view genomic region     (about GC identifiers)

Start:
220,378,892 bp from pter      End:
220,403,494 bp from pter
Size:
24,603 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ASIC4_HUMAN, Q96FT7 (See protein sequence)
Recommended Name: Acid-sensing ion channel 4  
Size: 647 amino acids; 70105 Da
Subunit: Homotrimer or heterotrimer with other ASIC proteins (By similarity)
Sequence caution: Sequence=CAB93980.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAC51338.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q53SB7 Q6GMS1 Q6PIN9 Q9NQA4
Alternative splicing: 3 isoforms:  Q96FT7-1   Q96FT7-2   Q96FT7-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ASIC4: NX_Q96FT7

Explore proteomics data for ASIC4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn318, Asn370, Asn484
  • Modification sites at PhosphoSitePlus

  • See ASIC4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_878267.2  
    ENSEMBL proteins: 
     ENSP00000326627   ENSP00000350786  
    Reactome Protein details: Q96FT7

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ASIC: Ion channels / Acid-sensing (proton-gated) ion channels

    2 InterPro protein domains:
     IPR020903 Na+channel_ASC_CS
     IPR001873 Na+channel_ASC

    Graphical View of Domain Structure for InterPro Entry Q96FT7

    ProtoNet protein and cluster: Q96FT7

    1 Blocks protein domain: IPB001873 Na+ channel

    UniProtKB/Swiss-Prot: ASIC4_HUMAN, Q96FT7
    Similarity: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC4 subfamily


    Find genes that share domains with ASIC4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ASIC4_HUMAN, Q96FT7
    Function: Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity TAS10852210
    GO:0005272sodium channel activity IEA--
    GO:0015081sodium ion transmembrane transporter activity TAS10852210
         
    Find genes that share ontologies with ASIC4           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ASIC4

    miRNA
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    miRTarBase miRNAs that target ASIC4:
    hsa-mir-335-5p (MIRT018746)

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    SwitchGear 3'UTR luciferase reporter plasmidASIC4 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ASIC4_HUMAN, Q96FT7: Membrane; Multi-pass membrane protein (By similarity)

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane TAS10852210
    GO:0016020membrane ----

    Find genes that share ontologies with ASIC4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ASIC4 About    
    See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.58
    Stimuli-sensing channels0.58
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47
    3Development Endothelin 1 EDNRA signaling
    Inflammatory mediator regulation of TRP channels0.37


    Find genes that share SuperPaths with ASIC4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ASIC4
        Stimuli-sensing channels


    1 Kegg Pathway  (Kegg details for ASIC4):
        Inflammatory mediator regulation of TRP channels

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ASIC4
    Interactions:

        Search GeneGlobe Interaction Network for ASIC4

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS10852210
    GO:0006814sodium ion transport ----
    GO:0034220ion transmembrane transport TAS10852210
    GO:0035725sodium ion transmembrane transport TAS10852210

    Find genes that share ontologies with ASIC4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ASIC4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ASIC4 gene (2 alternative transcripts): 
    NM_182847.2  NM_018674.4  

    Unigene Cluster for ASIC4:

    Acid-sensing (proton-gated) ion channel family member 4
    Hs.87469  [show with all ESTs]
    Unigene Representative Sequence: AJ271643
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000461395(uc010fwi.2 uc010fwj.2 uc002vly.2) ENST00000347842(uc002vma.3)
    ENST00000358078(uc002vlz.3) ENST00000474489(uc002vmb.3) ENST00000473709

    miRNA
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    Additional mRNA sequence: 

    AJ271643.1 AK308804.1 AK309373.1 BC010439.1 BC031812.1 

    5 DOTS entries:

    DT.92068418  DT.95123878  DT.95159189  DT.95364662  DT.100709999 

    Selected AceView cDNA sequences (see all 25):

    BC010439 NM_018674 NM_182847 AA235984 BG913360 BP362381 BC031812 BG818664 
    BG911389 BG912088 BF529874 BG912216 BC073912 BG913294 AA235790 BX345391 
    BG910298 BI755609 BG818353 BF530791 BQ013503 BF529485 BG913866 BX350976 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ASIC4    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
    SP1:              -                       -     -     -                                       
    SP2:                                      -           -                                       
    SP3:                                      -                                                   
    SP4:              -                                                                           


    ECgene alternative splicing isoforms for ASIC4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ASIC4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCCTCACG
    ASIC4 Expression
    About this image


    ASIC4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 13 entries
             Thalamus
             brain/midbrain/lateral wall   
     
     Neural Tube (Nervous System)    fully expand to see all 7 entries
             Mesencephalic Roof Plate
             brain/midbrain/lateral wall   
     
     Ovary (Reproductive System)
             Granulosa Cells Primary Follicle
    ASIC4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ASIC4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.87469

    UniProtKB/Swiss-Prot: ASIC4_HUMAN, Q96FT7
    Tissue specificity: Expressed in pituitary gland. Weakly expressed in brain, vestibular system and organ of Corti

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ASIC4 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Asic41 , 5 amiloride-sensitive cation channel 4, pituitary5
    acid-sensing (proton-gated) ion channel family member more1
    91.15(n)1
    97.69(a)1
      1 (39.08 cM)5
    2411181  NM_183022.31  NP_898843.11 
     754504365 
    chicken
    (Gallus gallus)
    Aves ASIC41 acid-sensing (proton-gated) ion channel family member more 68.61(n)
    66.43(a)
      769191  XM_004942837.1  XP_004942894.1 
    lizard
    (Anolis carolinensis)
    Reptilia ASIC46
    acid-sensing (proton-gated) ion channel family mem...
    67(a)
    1 ↔ 1
    1(94784394-94905081)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia asic41 acid-sensing (proton-gated) ion channel family member more 65.19(n)
    66.58(a)
      100486325  XM_002933962.2  XP_002934008.2 
    zebrafish
    (Danio rerio)
    Actinopterygii asic4a1 acid-sensing (proton-gated) ion channel family member more 65.89(n)
    64.91(a)
      407668  NM_214787.2  NP_999952.1 


    ENSEMBL Gene Tree for ASIC4 (if available)
    TreeFam Gene Tree for ASIC4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ASIC4 gene
    SCNN1B2  ASIC32  SCNN1G2  SCNN1A2  SCNN1D2  ASIC22  ASIC52  ASIC12  
    3 SIMAP similar genes for ASIC4 using alignment to 1 protein entry:     ASIC4_HUMAN:
    ASIC2    ASIC1    ASIC3

    Find genes that share paralogs with ASIC4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ASIC4 (see all 644)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs784466821,2
    C,F--220377051(+) GATCTC/TAATAG 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs621915731,2
    C,F--220377102(+) GCAACG/AAGTGC 1 -- us2k13Minor allele frequency- A:0.09NA WA 124
    rs1447953601,2
    --220377134(+) TTTCCC/TGCTTT 1 -- us2k10--------
    rs730872471,2
    C,F--220377178(+) AAGCAA/GTTAAA 1 -- us2k12Minor allele frequency- G:0.02WA 120
    rs2003223391,2
    --220377192(+) CTTTT-/AAAAAA 1 -- us2k10--------
    rs1883464001,2
    --220377262(+) ACAGTC/GGGGGG 1 -- us2k10--------
    rs1501962521,2
    C--220377337(+) GGGAC-/AGAGAGA 1 -- us2k10--------
    rs1400429831,2
    C--220377425(+) TCTGGA/GACACT 1 -- us2k10--------
    rs1156394231,2
    F--220377600(+) CATGGT/ACAGGG 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs783939291,2
    C,F--220377651(+) GGGGCC/GTGACC 1 -- us2k11Minor allele frequency- G:0.07WA 118

    HapMap Linkage Disequilibrium report for ASIC4 (220378892 - 220403494 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ASIC4: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ASIC4
    DNA2.0 Custom Variant and Variant Library Synthesis for ASIC4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606715    OMIM disorders: --


    Find genes that share disorders with ASIC4           About GenesLikeMe


    Export disorders for ASIC4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ASIC4 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ASIC4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A new member of acid-sensing ion channels from pituitary gland. (PubMed id 10852210)1, 2, 3 Gruender S.... Ruppersberg J.P. (NeuroReport 2000)
    2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Acid-sensing ion channel (ASIC) 4 gene: physical mapping, genomic organisation, and evaluation as a candidate for paroxysmal dystonia. (PubMed id 11571555)1, 2 Gruender S.... Fink J.K. (Eur. J. Hum. Genet. 2001)
    5. Regulation of ASIC activity by ASIC4--new insights into ASIC channel function revealed by a yeast two-hybrid assay. (PubMed id 18662336)1 Donier E....Wood J.N. (Eur. J. Neurosci. 2008)
    6. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. Toward a complete human genome sequence. (PubMed id 9847074)1 Sulston J.E. and Waterston R. (Genome Res. 1998)
    9. A new member of the acid-sensing ion channel family. (PubMed id 10923674)9 Akopian A.N....Wood J.N. (Neuroreport 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Free Text  

      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55515 HGNC: 21263 AceView: ACCN4 Ensembl:ENSG00000072182 euGenes: HUgn55515
    ECgene: ASIC4 Kegg: 55515 H-InvDB: ASIC4

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ASIC4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ASIC4 gene:
    Search GeneIP for patents involving ASIC4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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