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ASIC3 Gene

protein-coding   GIFtS: 51
GCID: GC07P150746

Acid-Sensing (Proton-Gated) Ion Channel 3

(Previous names: amiloride-sensitive cation channel 3, testis, amiloride-sensitive...)
(Previous symbol: ACCN3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Acid-Sensing (Proton-Gated) Ion Channel 31 2     TNAC13 5
ACCN31 2 3 5     TNaC12
Testis Sodium Channel 11 2 3     Acid-Sensing Ion Channel 32
Amiloride-Sensitive Cation Channel 3, Testis1 2     Modulatory Subunit Of ASIC2a2
Amiloride-Sensitive Cation Channel 31 3     Proton-Gated Cation Channel Subunit2
Neuronal Amiloride-Sensitive Cation Channel 32 3     hASIC33
SLNAC12 3     hTNaC13
DRASIC2 5     

External Ids:    HGNC: 1011   Entrez Gene: 93112   Ensembl: ENSG000002131997   OMIM: 6117415   UniProtKB: Q9UHC33   

Export aliases for ASIC3 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ASIC3 Gene:
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this
family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic
transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing.
The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH
changes. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 2
has been observed as proton-gated channels sensitive to gadolinium. Alternatively spliced transcript variants
have been described. (provided by RefSeq, Feb 2012)

GeneCards Summary for ASIC3 Gene:
ASIC3 (acid-sensing (proton-gated) ion channel 3) is a protein-coding gene. Diseases associated with ASIC3 include allergic rhinitis, and rhinitis. GO annotations related to this gene include sodium channel activity and PDZ domain binding. An important paralog of this gene is SCNN1D.

UniProtKB/Swiss-Prot: ASIC3_HUMAN, Q9UHC3
Function: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by
the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In
sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed
tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems
to modulate channel properties

Gene Wiki entry for ASIC3 (ACCN3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007933.16  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ASIC3
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidASIC3 promoter sequence
   Search Chromatin IP Primers for ASIC3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ASIC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q35   Ensembl cytogenetic band:  7q36.1   HGNC cytogenetic band: 7q35

ASIC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASIC3 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P150746:  view genomic region     (about GC identifiers)

Start:
150,745,379 bp from pter      End:
150,749,843 bp from pter
Size:
4,465 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 150,075,144-150,079,382     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ASIC3_HUMAN, Q9UHC3 (See protein sequence)
Recommended Name: Acid-sensing ion channel 3  
Size: 531 amino acids; 58905 Da
Subunit: Homotrimer or heterotrimer with other ASIC proteins (By similarity). Interacts with STOM and DLG4 (By
similarity). Interacts with LIN7B, MAGI1/BAIAP1, GOPC and ASIC2
Developmental stage: Expressed in fetal tissues, expression increases in lung and kidney adult tissues
Miscellaneous: Potentiated by FMRFamide-related neuropeptides. Sensitized and potentiated by NPSF. Regulated by
lactate and Ca(2+). Inhibited by anti-inflammatory drugs, like salicylic acid (By similarity). Sensitized and
potentiated by NPFF
Sequence caution: Sequence=BAA25897.1; Type=Frameshift; Positions=303, 305, 313; Sequence=BAD92658.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B2R9V0 O60263 O75906 Q59FN9 Q9UER8 Q9UHC4
Alternative splicing: 4 isoforms:  Q9UHC3-1   Q9UHC3-2   Q9UHC3-3   Q9UHC3-4   

Explore the universe of human proteins at neXtProt for ASIC3: NX_Q9UHC3

Explore proteomics data for ASIC3 at MOPED

Post-translational modifications: 

  • Phosphorylated by PKA. Phosphorylated by PKC. In vitro, PRKCABP/PICK-1 is necessary for PKC phosphorylation and
    activation of a ASIC3/ACCN3-ASIC2/ASIC2b channel, but does not activate a homomeric ASIC3 channel (By similarity)1
  • Glycosylation2 at Asn175, Asn398
  • Modification sites at PhosphoSitePlus

  • See ASIC3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_004760.1  NP_064717.1  NP_064718.1  

    ENSEMBL proteins: 
     ENSP00000350600   ENSP00000367136   ENSP00000344838   ENSP00000418605   ENSP00000297512  
     ENSP00000420371   ENSP00000418361  
    Reactome Protein details: Q9UHC3

    ASIC3 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ASIC: Ion channels / Acid-sensing (proton-gated) ion channels

    IUPHAR Guide to PHARMACOLOGY protein family classification: ASIC3
    Acid-sensing (proton-gated) ion channels (ASICs)

    3 InterPro protein domains:
     IPR004724 EnaC
     IPR020903 Na+channel_ASC_CS
     IPR001873 Na+channel_ASC

    Graphical View of Domain Structure for InterPro Entry Q9UHC3

    ProtoNet protein and cluster: Q9UHC3

    1 Blocks protein domain: IPB001873 Na+ channel

    UniProtKB/Swiss-Prot: ASIC3_HUMAN, Q9UHC3
    Domain: The PDZ domain-binding motif is involved in interaction with LIN7A, GOPC and MAGI1
    Similarity: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC3 subfamily


    ASIC3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ASIC3_HUMAN, Q9UHC3
    Function: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by
    the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In
    sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed
    tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems
    to modulate channel properties

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005261cation channel activity TAS9744806
    GO:0005272sodium channel activity TAS9571199
    GO:0005515protein binding ----
    GO:0015280ligand-gated sodium channel activity IEA--
    GO:0030165PDZ domain binding IEA--
         
    ASIC3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ASIC3:
     Increased cell number in G1, a 

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Asic3):
     behavior/neurological  cellular  hearing/vestibular/ear  homeostasis/metabolism  integument 
     nervous system  vision/eye 

    ASIC3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ASIC3: Asic3tm1Pho Asic3tm1Wsh

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ASIC3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ASIC3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ASIC3

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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ASIC3_HUMAN, Q9UHC3: Cell membrane; Multi-pass membrane protein (By similarity). Cytoplasm (By similarity).
    Note=Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction
    with DLG4. In part cytoplasmic in cochlea cells (By similarity)

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----

    ASIC3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ASIC3 About    
    See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.58
    Stimuli-sensing channels0.58
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47
    3Development Endothelin 1 EDNRA signaling
    Inflammatory mediator regulation of TRP channels0.37
    4Sodium channels and transporters inward current
    Sodium channels and transporters inward current
    5CFTR dependent regulation of ion channels in Airway Epithelium norm and CF
    CFTR dependent regulation of ion channels in Airway Epithelium norm and CF

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for ASIC3
        CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)

    1 Reactome Pathway for ASIC3
        Stimuli-sensing channels


    1 Kegg Pathway  (Kegg details for ASIC3):
        Inflammatory mediator regulation of TRP channels


    ASIC3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ASIC3
    Interactions:

        Search GeneGlobe Interaction Network for ASIC3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for ASIC3 (Q9UHC33 ENSP000002975124) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ASIC2Q165153, ENSP000002258234I2D: score=3 STRING: ENSP00000225823
    LIN7BQ9HAP63, ENSP000002214594I2D: score=3 STRING: ENSP00000221459
    PRKACAP176123, ENSP000003095914I2D: score=1 STRING: ENSP00000309591
    SLC9A3R1O147453, ENSP000002626134I2D: score=1 STRING: ENSP00000262613
    STOML1Q9UBI43, ENSP000003193234I2D: score=1 STRING: ENSP00000319323
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001101response to acid IEA--
    GO:0006810transport TAS9744806
    GO:0006812cation transport ----
    GO:0006814sodium ion transport ----
    GO:0007165signal transduction TAS9744806

    ASIC3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ASIC3

    Selected IUPHAR Ligands for ASIC3 (ASIC3) (see all 13)    About this table
    LigandTypeActionAffinityPubmed IDs
    APETx2
    Channel blockerNone7.2--
    H+ (extracellular)
    ActivatorNone6.2 - 6.7--
    nafamostat
    Channel blockerNone5.6--
    A317567
    Channel blockerNone5--
    amiloride
    Channel blockerNone4.2 - 4.8--
    Gd3+
    Channel blockerNone4.4--
    Zn2+
    Channel blockerNone4.2--
    aspirin
    Channel blockerNone4--
    diclofenac
    Channel blockerNone4--
    salicylic acid
    Channel blockerNone3.6--

    2 Novoseek inferred chemical compound relationships for ASIC3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    amiloride 67.3 3 19339181 (2), 19482897 (1)
    sodium 37.8 5 16915087 (2), 15317815 (1), 9571199 (1), 14522957 (1)



    ASIC3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ASIC3 gene (3 alternative transcripts): 
    NM_004769.3  NM_020321.3  NM_020322.3  

    Unigene Cluster for ASIC3:

    Acid-sensing (proton-gated) ion channel 3
    Hs.647113  [show with all ESTs]
    Unigene Representative Sequence: NM_020321
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357922(uc003win.2 uc003wio.2 uc003wip.2) ENST00000377904(uc003wiq.2)
    ENST00000349064 ENST00000468325 ENST00000297512 ENST00000474135 ENST00000485929
    ENST00000490540 ENST00000498105
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      QuantiFast Probe-based Assays in human, mouse, rat ASIC3

    Additional mRNA sequence: 

    AB209421.1 AF057711.1 AF095897.1 AF195024.1 AF195025.1 AK124944.1 AK313926.1 BC030282.1 
    NR_046401.1 

    8 DOTS entries:

    DT.210692  DT.210693  DT.100795799  DT.92420207  DT.40261078  DT.95327021  DT.95368805  DT.91648554 

    Selected AceView cDNA sequences (see all 204):

    AK128129 BM463415 BM552265 BM704396 BI490066 CR599833 AA825988 BM694370 
    BQ678344 AK094005 BQ718758 BQ223720 BM703142 CR610778 AI420480 CR616094 
    AA309016 AK094636 AW960651 BM976848 CB129709 CR595185 AF195025 CR592221 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ASIC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTAGCCTGC
    ASIC3 Expression
    About this image


    ASIC3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neurons
             Mature Rod Cells Outer Nuclear Layer
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Mature Rod Cells Outer Nuclear Layer
    ASIC3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ASIC3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.647113

    UniProtKB/Swiss-Prot: ASIC3_HUMAN, Q9UHC3
    Tissue specificity: Expressed by sensory neurons. Strongly expressed in brain, spinal chord, lung, lymph nodes,
    kidney, pituitary, heart and testis

        Custom PCR Arrays for ASIC3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASIC3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ASIC3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Asic31 , 5 amiloride-sensitive cation channel 35
    acid-sensing (proton-gated) ion channel 31
    80.53(n)1
    82.61(a)1
      5 (11.72 cM)5
    1712091  NM_183000.21  NP_892045.21 
     244134515 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    35(a)
    many ↔ many
    27(2153765-2179370) ENSGALG00000019824
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    46(a)
    many ↔ many
    2(91704519-91741882)
    zebrafish
    (Danio rerio)
    Actinopterygii asic1b6
    acid-sensing (proton-gated) ion channel 1b
    43(a)
    many ↔ many
    22(6991902-7206812) ENSDARG00000027512


    ENSEMBL Gene Tree for ASIC3 (if available)
    TreeFam Gene Tree for ASIC3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ASIC3 gene
    SCNN1D2  SCNN1B2  SCNN1G2  SCNN1A2  ASIC52  ASIC22  ASIC42  ASIC12  
    3 SIMAP similar genes for ASIC3 using alignment to 3 protein entries:     ASIC3_HUMAN (see all proteins):
    ASIC2    ASIC1    ASIC4

    ASIC3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ASIC3 (see all 212)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1480674611,2
    --150745474(+) ACTGCA/GGTTTC 4 -- ut51 nc-transcript-variant0--------
    rs1417782401,2
    --150745579(+) CTGCTC/GTGTCG 4 -- ut51 nc-transcript-variant0--------
    rs1381153291,2
    --150745790(+) CCAGAA/TCACCT 4 -- ut51 nc-transcript-variant0--------
    rs1907139871,2
    --150745824(+) CCTCCC/GTGCCT 4 -- ut51 nc-transcript-variant0--------
    rs2020756251,2
    --150745925(+) CTCTCC/TCGCTT 4 -- ut51 nc-transcript-variant0--------
    rs2009770051,2
    --150745926(+) TCTCTC/TGCTTC 4 -- ut51 nc-transcript-variant0--------
    rs1500918121,2
    C,F--150745956(+) GTTCCG/ACTCCT 4 -- ut51 nc-transcript-variant1Minor allele frequency- A:0.03EU 651
    rs1434276201,2
    C--150745974(+) GGCCAT/CGAAGC 7 /T /M mis11Minor allele frequency- C:0.00NA 2474
    rs2003916061,2
    --150745997(+) CAGAGA/GAGGCC 7 K E mis10--------
    rs1143146981,2
    C--150746004(+) GGCCCG/AGCGGC 7 /Q /R mis11Minor allele frequency- A:0.01NA 210

    HapMap Linkage Disequilibrium report for ASIC3 (150745379 - 150749843 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ASIC3: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing ASIC3
    DNA2.0 Custom Variant and Variant Library Synthesis for ASIC3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611741    OMIM disorders: --

    8 diseases for ASIC3:    
    About MalaCards
    allergic rhinitis    rhinitis    neuronitis    purpura
    cystic fibrosis    insulin resistance    ischemia    arthritis


    ASIC3 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for ASIC3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acidosis 62.3 2 16915087 (1), 14522957 (1)
    hyperalgesia 36 2 14522957 (1)


    Export disorders for ASIC3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ASIC3 gene, integrated from 10 sources (see all 51):
    (articles sorted by number of sources associating them with ASIC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification, functional expression and chromosomal localisation of a sustained human proton-gated cation channel. (PubMed id 9744806)1, 2, 3, 9 de Weille J.R.... Waldmann R. (FEBS Lett. 1998)
    2. Molecular cloning of a DEG/ENaC sodium channel cDNA from human testis. (PubMed id 9571199)1, 2, 3, 9 Ishibashi K. and Marumo F. (Biochem. Biophys. Res. Commun. 1998)
    3. PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current. (PubMed id 15317815)1, 2, 9 Hruska-Hageman A.M....Welsh M.J. (J. Biol. Chem. 2004)
    4. Molecular cloning and regional distribution of a human proton receptor subunit with biphasic functional properties. (PubMed id 9886053)1, 2, 9 Babinski K.... Seguela P. (J. Neurochem. 1999)
    5. cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C- kinase-1. (PubMed id 12578970)1, 2 Leonard A.S.... Welsh M.J. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    6. Selective modulation of heteromeric ASIC proton-gated channels by neuropeptide FF. (PubMed id 11587714)1, 2 Catarsi S.... Seguela P. (Neuropharmacology 2001)
    7. Mammalian ASIC2a and ASIC3 subunits co-assemble into heteromeric proton-gated channels sensitive to Gd3+. (PubMed id 10842183)1, 2 Babinski K.... Seguela P. (J. Biol. Chem. 2000)
    8. Interregulation of proton-gated Na(+) channel 3 and cystic fibrosis transmembrane conductance regulator. (PubMed id 17012229)1, 9 Su X....Ji H.L. (J. Biol. Chem. 2006)
    9. Genetic variation in the ASIC3 gene influences blood pressure levels in Taiwanese. (PubMed id 18854755)1, 9 Ko Y.L....Cheng C.F. (J. Hypertens. 2008)
    10. The potential role of transient receptor potential type A1 as a mechanoreceptor in human periodontal ligament cells. (PubMed id 24206072)1 Tsutsumi T....Okabe K. (Eur. J. Oral Sci. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9311 HGNC: 101 AceView: ACCN3andABCB8 Ensembl:ENSG00000213199 euGenes: HUgn9311
    ECgene: ASIC3 Kegg: 9311 H-InvDB: ASIC3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ASIC3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ASIC3 gene:
    Search GeneIP for patents involving ASIC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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