Aliases for ASIC3 Gene
Aliases for ASIC3 Gene
External Ids for ASIC3 Gene
- HGNC: 101
- Entrez Gene: 9311
- Ensembl: ENSG00000213199
- OMIM: 611741
- UniProtKB: Q9UHC3
Previous HGNC Symbols for ASIC3 Gene
- ACCN3
Previous GeneCards Identifiers for ASIC3 Gene
- GC07P150746
Summaries for ASIC3 Gene
-
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 2 has been observed as proton-gated channels sensitive to gadolinium. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]
GeneCards Summary for ASIC3 Gene
ASIC3 (Acid Sensing Ion Channel Subunit 3) is a Protein Coding gene. Diseases associated with ASIC3 include Frozen Shoulder and Deafness, Autosomal Recessive 13. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Ion channel transport. GO annotations related to this gene include PDZ domain binding and sodium channel activity. An important paralog of this gene is ASIC1.
UniProtKB/Swiss-Prot for ASIC3 Gene
-
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.
-
Acid-sensing ion channels (ASIC) are members of the ENaC/Deg (epithelial amiloride-sensitive Na+ channel and degenerin) family of ion channels and are widely expressed in neurons of the central and peripheral nervous system.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASIC3 Gene
Genomics for ASIC3 Gene
Regulatory Elements for ASIC3 Gene
Enhancers for ASIC3 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ASIC3 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for ASIC3 Gene
- Chromosome:
- 7
- Start:
- 151,048,292 bp from pter
- End:
- 151,052,756 bp from pter
- Size:
- 4,465 bases
- Orientation:
- Plus strand
Genomic View for ASIC3 Gene
Genes around ASIC3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q36.1 by Ensembl
- 7q36.1 by Entrez Gene
- 7q36.1 by HGNC
ASIC3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ASIC3 Gene
Proteins for ASIC3 Gene
-
Protein details for ASIC3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UHC3-ASIC3_HUMAN
- Recommended name:
- Acid-sensing ion channel 3
- Protein Accession:
- Q9UHC3
- B2R9V0
- O60263
- O75906
- Q59FN9
- Q9UER8
- Q9UHC4
Protein attributes for ASIC3 Gene
- Size:
- 531 amino acids
- Molecular mass:
- 58905 Da
- Quaternary structure:
-
- Homotrimer or heterotrimer with other ASIC proteins (By similarity). Interacts with STOM; this regulates channel activity. Interacts with DLG4 (By similarity). Interacts with LIN7B, MAGI1/BAIAP1, GOPC and ASIC2.
- Miscellaneous:
-
- Potentiated by FMRFamide-related neuropeptides. Sensitized and potentiated by NPSF. Regulated by lactate and Ca(2+). Inhibited by anti-inflammatory drugs, like salicylic acid (By similarity). Sensitized and potentiated by NPFF.
- SequenceCaution:
-
- Sequence=BAA25897.1; Type=Frameshift; Positions=303, 305, 313; Evidence={ECO:0000305}; Sequence=BAD92658.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Post-translational modifications for ASIC3 Gene
- Phosphorylated by PKA. Phosphorylated by PKC. In vitro, PRKCABP/PICK-1 is necessary for PKC phosphorylation and activation of a ASIC3/ACCN3-ASIC2/ASIC2b channel, but does not activate a homomeric ASIC3 channel (By similarity).
- Glycosylation at posLast=175175 and Asn398
- Modification sites at PhosphoSitePlus
Other Protein References for ASIC3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for ASIC3
-
Custom Antibody ServicesOriGene Antibodies for ASIC3
- Novus Biologicals Antibodies for ASIC3
- Invitrogen Antibodies for ASIC3
- antibodies-online Antibodies for ASIC3: See all 43
- GeneTex ASIC3 antibody for ASIC3
Protein Products
-
OriGene Purified Proteins for ASIC3
- Search Origene for MassSpec and Protein Over-expression Lysates for ASIC3
- Origene Custom Protein Services for ASIC3
- Search GeneTex for Proteins for ASIC3
Assay Products
- antibodies-online Kits for ASIC3: See all 8
No data available for DME Specific Peptides for ASIC3 Gene
Domains & Families for ASIC3 Gene
Gene Families for ASIC3 Gene
- HGNC:
- IUPHAR :
Protein Domains for ASIC3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ASIC3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9UHC3UniProtKB/Swiss-Prot:
ASIC3_HUMAN :- The PDZ domain-binding motif is involved in interaction with LIN7A, GOPC and MAGI1.
- Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC3 subfamily.
- Domain:
-
- The PDZ domain-binding motif is involved in interaction with LIN7A, GOPC and MAGI1.
- Family:
-
- Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC3 subfamily.
Function for ASIC3 Gene
Molecular function for ASIC3 Gene
- UniProtKB/Swiss-Prot Function:
- Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005261 | cation channel activity | TAS | 9744806 |
| GO:0005272 | sodium channel activity | TAS,IEA | 9571199 |
| GO:0015280 | ligand-gated sodium channel activity | IEA | -- |
| GO:0030165 | PDZ domain binding | IEA | -- |
| GO:0042931 | enterobactin transporter activity | IEA | -- |
Phenotypes for ASIC3 Gene
- MGI mutant phenotypes for ASIC3:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for ASIC3:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for ASIC3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ASIC3 gene
- Search ViGene Biosciences for ASIC3
CRISPR Products
-
OriGene CRISPR knockouts for ASIC3
-
Santa Cruz Biotechnology (SCBT) CRISPR for ASIC3
- GenScript: Design CRISPR guide RNA sequences for ASIC3
miRNA Products
- Search ViGene Biosciences for ASIC3
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ASIC3
- Browse OriGene Inhibitory RNA Products For ASIC3
-
ViGene Biosciences ready-to-package AAV shRNAs for ASIC3 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ASIC3
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ASIC3
-
ViGene Biosciences adenoviral particle packaged cDNA for ASIC3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ASIC3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ASIC3 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ASIC3 Gene
Localization for ASIC3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ASIC3 Gene
- Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4. In part cytoplasmic in cochlea cells (By similarity). {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 2 |
| cytosol | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | IEA,TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for ASIC3 Gene
Pathways by source for ASIC3 Gene
3 Reactome pathways for ASIC3 Gene
1 KEGG pathway for ASIC3 Gene
1 GeneGo (Thomson Reuters) pathway for ASIC3 Gene
Interacting Proteins for ASIC3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | TAS,IEA | 9744806 |
| GO:0006811 | ion transport | IEA | -- |
| GO:0006812 | cation transport | IEA | -- |
| GO:0006814 | sodium ion transport | IEA | -- |
| GO:0007165 | signal transduction | TAS | 9744806 |
No data available for SIGNOR curated interactions for ASIC3 Gene
Drugs & Compounds for ASIC3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Salicylic acid | Approved, Vet_approved | Pharma | Channel blocker | 189 | ||
| Amiloride | Approved | Pharma | Channel blocker, blocker | 53 | ||
| Aspirin | Approved, Vet_approved | Pharma | Channel blocker, inhibitor | 1152 | ||
| Diclofenac | Approved, Vet_approved | Pharma | Channel blocker, inhibitor | 323 | ||
| Nafamostat | Approved, Investigational | Pharma | Channel blocker | 4 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| sodium |
|
7440-23-5 | ||||
| A317567 |
|
Channel blocker |
|
|
||
| H<sup>+</sup> (extracellular) |
|
Activator |
|
|
||
| Mambalgin 1 |
|
1609937-15-6 |
|
|
(5) Tocris Compounds for ASIC3 Gene
| Compound | Action | Cas Number |
|---|---|---|
| APETx2 | ASIC3 channel blocker | 713544-47-9 |
| GMQ hydrochloride | Selective ASIC3 opener | 5361-15-9 |
| Mambalgin 1 | Selective ASIC1a inhibitor; analgesic | 1609937-15-6 |
| Neuropeptide SF (mouse, rat) | NPFF1 and NPFF2 agonist | 230960-31-3 |
| Psalmotoxin 1 | Potent and selective ASIC1a channel blocker |
(2) ApexBio Compounds for ASIC3 Gene
| Compound | Action | Cas Number |
|---|---|---|
| GMQ hydrochloride | 5361-15-9 | |
| β-Pompilidotoxin | Slows Na+ channel inactivation | 216064-36-7 |
Drug Products
- ApexBio compounds for ASIC3
Transcripts for ASIC3 Gene
mRNA/cDNA for ASIC3 Gene
- (3) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (204) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ASIC3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ASIC3
-
Santa Cruz Biotechnology (SCBT) CRISPR for ASIC3
- GenScript: Design CRISPR guide RNA sequences for ASIC3
miRNA Products
- Search ViGene Biosciences for ASIC3
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ASIC3
- Browse OriGene Inhibitory RNA Products For ASIC3
-
ViGene Biosciences ready-to-package AAV shRNAs for ASIC3 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ASIC3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ASIC3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for ASIC3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- Mature Rod Bipolar Cells Inner Nuclear Layer
- Mature Rod Cells Outer Nuclear Layer
- Type1 Off Cone Bipolar Cells Inner Nuclear Layer
-
Neurons
- Mature Rod Bipolar Cells Inner Nuclear Layer
- Mature Rod Cells Outer Nuclear Layer
- Type1 Off Cone Bipolar Cells Inner Nuclear Layer
mRNA differential expression in normal tissues according to GTEx for ASIC3 Gene
This gene is overexpressed in Brain - Cerebellum (x5.1) and Brain - Cerebellar Hemisphere (x4.2).
NURSA nuclear receptor signaling pathways regulating expression of ASIC3 Gene:
ASIC3SOURCE GeneReport for Unigene cluster for ASIC3 Gene:
Hs.647113mRNA Expression by UniProt/SwissProt for ASIC3 Gene:
Q9UHC3-ASIC3_HUMAN
Tissue specificity:
Expressed by sensory neurons. Strongly expressed in brain, spinal chord, lung, lymph nodes, kidney, pituitary, heart and testis.
Evidence on tissue expression from TISSUES for ASIC3 Gene
- Nervous system(4.6)
- Muscle(2)
Primer Products
-
OriGene qPCR primer pairs for ASIC3
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ASIC3 Gene
Orthologs for ASIC3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ACCN3 34 |
|
||
| ASIC3 35 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | ACCN3 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | ASIC3 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Asic3 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Asic3 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ASIC3 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | ASIC3 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | -- 35 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
ManyToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | asic1b 35 |
|
ManyToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany |
- Species where no ortholog for ASIC3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ASIC3 Gene
Variants for ASIC3 Gene
| SNP ID | Clin | Chr 07 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000432561 | -- | 151,052,691(+) | ACATC(C/T)TGGAC | nc-transcript-variant, reference, synonymous-codon, utr-variant-3-prime | |
| rs1000790542 | -- | 151,048,333(+) | GGCAT(A/C)TCCAG | nc-transcript-variant, utr-variant-5-prime | |
| rs1001062521 | -- | 151,053,256(+) | TGAGA(C/T)GGTGG | downstream-variant-500B | |
| rs1001389994 | -- | 151,047,280(+) | AGCCG(A/C/T)GCCGT | upstream-variant-2KB, utr-variant-3-prime | |
| rs1001435942 | -- | 151,051,373(+) | GGGGC(C/G)GAACG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3695n106 | OTHER | inversion | 24896259 |
| dgv6756n100 | CNV | gain | 25217958 |
| nsv1067934 | OTHER | inversion | 25765185 |
| nsv1151906 | OTHER | inversion | 26484159 |
| nsv524928 | CNV | gain | 19592680 |
| nsv526410 | CNV | loss | 19592680 |
| nsv831188 | CNV | loss | 17160897 |
| nsv951648 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.92;
48.96% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ASIC3 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASIC3 Gene
Disorders for ASIC3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| frozen shoulder |
|
|
| deafness, autosomal recessive 13 |
|
|
| dentin sensitivity |
|
|
Search ASIC3 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for ASIC3
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- ASIC3
No data available for UniProtKB/Swiss-Prot and Genatlas for ASIC3 Gene
Publications for ASIC3 Gene
- Molecular cloning of a DEG/ENaC sodium channel cDNA from human testis. (PMID: 9571199) Ishibashi K. … Marumo F. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 22 64
- Identification, functional expression and chromosomal localisation of a sustained human proton-gated cation channel. (PMID: 9744806) de Weille J.R. … Waldmann R. (FEBS Lett. 1998) 2 3 4 22 64
- PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current. (PMID: 15317815) Hruska-Hageman A.M. … Welsh M.J. (J. Biol. Chem. 2004) 3 4 22 64
- Molecular cloning and regional distribution of a human proton receptor subunit with biphasic functional properties. (PMID: 9886053) Babinski K. … Seguela P. (J. Neurochem. 1999) 3 4 22 64
- Genetic variation in the ASIC3 gene influences blood pressure levels in Taiwanese. (PMID: 18854755) Ko Y.L. … Cheng C.F. (J. Hypertens. 2008) 3 22 64
Products for ASIC3 Gene
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- Custom Antibody ServicesOriGene Antibodies for ASIC3
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- Novus Biologicals Antibodies for ASIC3
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- Novus Biologicals
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- Invitrogen Antibodies for ASIC3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for ASIC3
- antibodies-online Antibodies for ASIC3: See all 43
- antibodies-online Kits for ASIC3: See all 8
- Search antibodies-online for proteins
- Search antibodies-online for peptides
- GeneTex ASIC3 antibody for ASIC3
- Search GeneTex for Proteins for ASIC3
- ViGene Biosciences adenoviral particle packaged cDNA for ASIC3 gene
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- Search ViGene Biosciences for ASIC3
- Horizon Cell Lines for ASIC3
- Cyagen custom Knockout/knockin (KOKI) mouse models for ASIC3
- VectorBuilder custom plasmid, inducible vectors for ASIC3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ASIC3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ASIC3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
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