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Aliases for ASIC2 Gene

Aliases for ASIC2 Gene

  • Acid Sensing (Proton Gated) Ion Channel 2 2 3
  • Amiloride-Sensitive Cation Channel 1, Neuronal 2 3 4
  • ACCN1 3 4 6
  • BNC1 3 4 6
  • MDEG 3 4 6
  • Acid-Sensing (Proton-Gated) Ion Channel 2 2 3
  • Mammalian Degenerin Homolog 3 4
  • Brain Sodium Channel 1 3 4
  • BNaC1 3 4
  • ACCN 3 4
  • Neuronal Amiloride-Sensitive Cation Channel 1 3
  • Amiloride-Sensitive Cation Channel Neuronal 1 4
  • Amiloride-Sensitive Brain Sodium Channel 4
  • Acid-Sensing Ion Channel 2 3
  • Degenerin 2
  • ASIC2a 3
  • HBNaC1 3

External Ids for ASIC2 Gene

Previous Symbols for ASIC2 Gene

  • ACCN
  • ACCN1

Summaries for ASIC2 Gene

Entrez Gene Summary for ASIC2 Gene

  • This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Feb 2012]

GeneCards Summary for ASIC2 Gene

ASIC2 (Acid Sensing (Proton Gated) Ion Channel 2) is a Protein Coding gene. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include voltage-gated sodium channel activity and ligand-gated sodium channel activity. An important paralog of this gene is SCNN1G.

UniProtKB/Swiss-Prot for ASIC2 Gene

  • Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate

Gene Wiki entry for ASIC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASIC2 Gene

Genomics for ASIC2 Gene

Genomic Location for ASIC2 Gene

33,013,087 bp from pter
34,174,964 bp from pter
1,161,878 bases
Minus strand

Genomic View for ASIC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ASIC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASIC2 Gene

No data available for Regulatory Elements for ASIC2 Gene

Proteins for ASIC2 Gene

  • Protein details for ASIC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Acid-sensing ion channel 2
    Protein Accession:
    Secondary Accessions:
    • E9PBX2
    • Q13553
    • Q6DJU1
    • Q8N3E2

    Protein attributes for ASIC2 Gene

    512 amino acids
    Molecular mass:
    57709 Da
    Quaternary structure:
    • Homotrimer or heterotrimer with other ASIC proteins (By similarity). Interacts with STOM; this regulates channel activity (By similarity). Interacts with PRKCABP and ASIC3.
    • Inhibited by anti-inflammatory drugs like salicylic acid (By similarity). Regulated by Zn(2+).

    Alternative splice isoforms for ASIC2 Gene


neXtProt entry for ASIC2 Gene

Proteomics data for ASIC2 Gene at MOPED

Post-translational modifications for ASIC2 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn365 and Asn392

Other Protein References for ASIC2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ASIC2 Gene

Domains for ASIC2 Gene

Gene Families for ASIC2 Gene

  • ASIC :Ion channels / Acid-sensing (proton-gated) ion channels

Protein Domains for ASIC2 Gene


  • Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC2 subfamily.:
    • Q16515
genes like me logo Genes that share domains with ASIC2: view

Function for ASIC2 Gene

Molecular function for ASIC2 Gene

UniProtKB/Swiss-Prot Function: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate

Gene Ontology (GO) - Molecular Function for ASIC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005248 voltage-gated sodium channel activity IEA --
GO:0005261 cation channel activity --
GO:0005272 sodium channel activity --
GO:0005515 protein binding IPI 11802773
genes like me logo Genes that share ontologies with ASIC2: view
genes like me logo Genes that share phenotypes with ASIC2: view

Animal Models for ASIC2 Gene

MGI Knock Outs for ASIC2:

miRNA for ASIC2 Gene

miRTarBase miRNAs that target ASIC2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ASIC2 Gene

Localization for ASIC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ASIC2 Gene

Cell membrane; Multi-pass membrane protein. Note=Localized at the plasma membrane of neurons, in the soma and punctated peripheral processes. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for ASIC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
GO:0043005 neuron projection --
genes like me logo Genes that share ontologies with ASIC2: view

Pathways for ASIC2 Gene

genes like me logo Genes that share pathways with ASIC2: view

Pathways by source for ASIC2 Gene

Gene Ontology (GO) - Biological Process for ASIC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003026 regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback IEA --
GO:0006812 cation transport --
GO:0006814 sodium ion transport --
GO:0007268 synaptic transmission TAS 8626462
GO:0007417 central nervous system development TAS 8626462
genes like me logo Genes that share ontologies with ASIC2: view

Compounds for ASIC2 Gene

(5) IUPHAR Ligand for ASIC2 Gene

Ligand Type Action Affinity Pubmed IDs
H+ (extracellular) Activator None 5.4
A317567 Channel blocker None 4.5
nafamostat Channel blocker None 4.2
amiloride Channel blocker None
Cd2+ Channel blocker None

(5) Novoseek inferred chemical compound relationships for ASIC2 Gene

Compound -log(P) Hits PubMed IDs
amiloride 78.2 8
fmrfamide 67.7 1
sodium 65.6 20
hydrogen 13.2 3
calcium 0 1
genes like me logo Genes that share compounds with ASIC2: view

Transcripts for ASIC2 Gene

Unigene Clusters for ASIC2 Gene

Acid-sensing (proton-gated) ion channel 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ASIC2 Gene

No ASD Table

Relevant External Links for ASIC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ASIC2 Gene

mRNA expression in normal human tissues for ASIC2 Gene

mRNA differential expression in normal tissues according to GTEx for ASIC2 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (6.3), Brain - Frontal Cortex (BA9) (5.1), Brain - Hypothalamus (4.8), Brain - Amygdala (4.7), Brain - Cortex (4.4), and Brain - Hippocampus (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ASIC2 Gene

SOURCE GeneReport for Unigene cluster for ASIC2 Gene Hs.368417

mRNA Expression by UniProt/SwissProt for ASIC2 Gene

Tissue specificity: Brain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary.
genes like me logo Genes that share expressions with ASIC2: view

Orthologs for ASIC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ASIC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ASIC2 37
  • 98 (a)
(Bos Taurus)
Mammalia ACCN1 37
  • 73 (a)
(Canis familiaris)
Mammalia ASIC2 36
  • 95.62 (n)
  • 98.58 (a)
ASIC2 37
  • 98 (a)
(Mus musculus)
Mammalia Asic2 36
  • 92.78 (n)
  • 97.16 (a)
Asic2 16
Asic2 37
  • 97 (a)
(Monodelphis domestica)
Mammalia ASIC2 37
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 67 (a)
(Rattus norvegicus)
Mammalia Asic2 36
  • 92.72 (n)
  • 96.8 (a)
(Gallus gallus)
Aves ASIC2 37
  • 94 (a)
(Anolis carolinensis)
Reptilia ASIC2 37
  • 92 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14786 36
(Danio rerio)
Actinopterygii asic2 37
  • 70 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.156 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 35 (a)
-- 37
  • 28 (a)
Species with no ortholog for ASIC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ASIC2 Gene

Gene Tree for ASIC2 (if available)
Gene Tree for ASIC2 (if available)

Paralogs for ASIC2 Gene

Paralogs for ASIC2 Gene

Selected SIMAP similar genes for ASIC2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ASIC2: view

Variants for ASIC2 Gene

Sequence variations from dbSNP and Humsavar for ASIC2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2142 -- 33,853,118(+) CCACA(C/T)ACAAA intron-variant
rs2275 -- 33,208,483(+) GCTGG(A/C)ACTTT intron-variant
rs2278 -- 33,208,510(+) CCCTC(A/T)GAGCT intron-variant
rs16551 -- 33,058,240(-) TCGGT(C/T)TACCA intron-variant
rs16552 -- 33,040,932(-) GGTTG(A/G)ACCAC intron-variant

Relevant External Links for ASIC2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Structural Variations from Database of Genomic Variants (DGV) for ASIC2 Gene

Disorders for ASIC2 Gene

(3) Novoseek inferred disease relationships for ASIC2 Gene

Disease -log(P) Hits PubMed IDs
glioma 29.1 15
neurodegeneration 6.57 2
tumors 0 3
genes like me logo Genes that share disorders with ASIC2: view

No data available for UniProtKB/Swiss-Prot for ASIC2 Gene

Publications for ASIC2 Gene

  1. Cloning and expression of a novel human brain Na+ channel. (PMID: 8626462) Price M.P. … Welsh M.J. (J. Biol. Chem. 1996) 3 4 23
  2. The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans. (PMID: 8631835) Waldmann R. … Lazdunski M. (J. Biol. Chem. 1996) 3 4 23
  3. BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels. (PMID: 9037075) Garcia-Anoveros J. … Corey D.P. (Proc. Natl. Acad. Sci. U.S.A. 1997) 3 4 23
  4. Mammalian ASIC2a and ASIC3 subunits co-assemble into heteromeric proton-gated channels sensitive to Gd3+. (PMID: 10842183) Babinski K. … Seguela P. (J. Biol. Chem. 2000) 3 4 23
  5. The acid-sensitive ionic channel subunit ASIC and the mammalian degenerin MDEG form a heteromultimeric H+-gated Na+ channel with novel properties. (PMID: 9360943) Bassilana F. … Lazdunski M. (J. Biol. Chem. 1997) 3 23

Products for ASIC2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ASIC2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ASIC2
    • Block miRNA regulation of ASIC2 using miScript Target Protectors

    Sources for ASIC2 Gene

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