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ASIC2 Gene

protein-coding   GIFtS: 52
GCID: GC17M031341

Acid-Sensing (Proton-Gated) Ion Channel 2

(Previous names: amiloride-sensitive cation channel 1, neuronal)
(Previous symbols: ACCN, ACCN1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Acid-Sensing (Proton-Gated) Ion Channel 21 2     degenerin1
ACCN11 2 3 5     ASIC2a2
Amiloride-Sensitive Cation Channel 1, Neuronal1 2 3     Acid-Sensing Ion Channel 22
ACCN1 2 3     hBNaC12
BNC12 3 5     Neuronal Amiloride-Sensitive Cation Channel 12
MDEG2 3 5     BNAC13
Brain Sodium Channel 12 3     Amiloride-Sensitive Brain Sodium Channel3
Mammalian Degenerin Homolog2 3     Amiloride-Sensitive Cation Channel Neuronal 13
BNaC12 3     

External Ids:    HGNC: 991   Entrez Gene: 402   Ensembl: ENSG000001086847   OMIM: 6017845   UniProtKB: Q165153   

Export aliases for ASIC2 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ASIC2 Gene:
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this
family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic
transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing.
The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association
between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into
proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two
variants, encoding distinct isoforms, have been identified. (provided by RefSeq, Feb 2012)

GeneCards Summary for ASIC2 Gene:
ASIC2 (acid-sensing (proton-gated) ion channel 2) is a protein-coding gene. Diseases associated with ASIC2 include neuronitis, and panic disorder. GO annotations related to this gene include ligand-gated sodium channel activity and voltage-gated sodium channel activity. An important paralog of this gene is SCNN1B.

UniProtKB/Swiss-Prot: ASIC2_HUMAN, Q16515
Function: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by
the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating
and a slow sustained phase. Heteromeric channel assembly seems to modulate

Gene Wiki entry for ASIC2 (ACCN1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ASIC2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidASIC2 promoter sequence
   Search Chromatin IP Primers for ASIC2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ASIC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q11.2-q12

ASIC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASIC2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M031341:  view genomic region     (about GC identifiers)

Start:
31,340,105 bp from pter      End:
32,501,983 bp from pter
Size:
1,161,879 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ASIC2_HUMAN, Q16515 (See protein sequence)
Recommended Name: Acid-sensing ion channel 2  
Size: 512 amino acids; 57709 Da
Subunit: Homotrimer or heterotrimer with other ASIC proteins (By similarity). Interacts with STOM (By similarity).
Interacts with PRKCABP and ASIC3
Miscellaneous: Inhibited by anti-inflammatory drugs like salicylic acid (By similarity). Regulated by Zn(2+)
Secondary accessions: E9PBX2 Q13553 Q6DJU1 Q8N3E2
Alternative splicing: 2 isoforms:  Q16515-1   Q16515-2   (No experimental confirmation available. Ref.4 (CAD38879) sequence is in conflict in position: 67:H->R)

Explore the universe of human proteins at neXtProt for ASIC2: NX_Q16515

Explore proteomics data for ASIC2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn365, Asn392
  • Modification sites at PhosphoSitePlus

  • See ASIC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001085.2  NP_899233.1  

    ENSEMBL proteins: 
     ENSP00000225823   ENSP00000352934  
    Reactome Protein details: Q16515

    ASIC2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ASIC: Ion channels / Acid-sensing (proton-gated) ion channels

    IUPHAR Guide to PHARMACOLOGY protein family classification: ASIC2
    Acid-sensing (proton-gated) ion channels (ASICs)

    3 InterPro protein domains:
     IPR004724 EnaC
     IPR020903 Na+channel_ASC_CS
     IPR001873 Na+channel_ASC

    Graphical View of Domain Structure for InterPro Entry Q16515

    ProtoNet protein and cluster: Q16515

    1 Blocks protein domain: IPB001873 Na+ channel

    UniProtKB/Swiss-Prot: ASIC2_HUMAN, Q16515
    Similarity: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC2 subfamily


    ASIC2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ASIC2_HUMAN, Q16515
    Function: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by
    the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating
    and a slow sustained phase. Heteromeric channel assembly seems to modulate

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005248voltage-gated sodium channel activity IEA--
    GO:0005261cation channel activity ----
    GO:0005272sodium channel activity ----
    GO:0005515protein binding IPI11802773
         
    ASIC2 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for ASIC2:
     Decreased viability with pacli  Increased cell number in G2M,   Increased gamma-H2AX phosphory  Increased homologous recombina 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Asic2):
     behavior/neurological  cardiovascular system  hearing/vestibular/ear  muscle  nervous system 
     no phenotypic analysis  taste/olfaction  vision/eye 

    ASIC2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ASIC2: Asic2tm1Wsh Asic2tm1.1Lzd

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ASIC2
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    miRNA
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    miRTarBase miRNAs that target ASIC2:
    hsa-mir-26b-5p (MIRT029748), hsa-mir-335-5p (MIRT018429)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ASIC2_HUMAN, Q16515: Cell membrane; Multi-pass membrane protein (By similarity). Note=Localized at the plasma
    membrane of neurons, in the soma and punctated peripheral processes (By similarity)

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----
    GO:0043005neuron projection ----

    ASIC2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ASIC2 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.58
    Stimuli-sensing channels0.58
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47
    3Taste transduction
    Taste transduction0.45
    4Development Endothelin 1 EDNRA signaling
    Inflammatory mediator regulation of TRP channels0.37
    5Synaptic transmission ion currents
    Synaptic transmission ion currents

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ASIC2
        Stimuli-sensing channels


    2 Kegg Pathways  (Kegg details for ASIC2):
        Taste transduction
    Inflammatory mediator regulation of TRP channels


    ASIC2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ASIC2
    Interactions:

        Search GeneGlobe Interaction Network for ASIC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for ASIC2 (Q165151, 2, 3 ENSP000002258234) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PICK1Q9NRD51, 3, ENSP000003494654EBI-79149,EBI-79165 I2D: score=8 STRING: ENSP00000349465
    ASIC3Q9UHC33, ENSP000002975124I2D: score=3 STRING: ENSP00000297512
    ASIC1P783483, ENSP000002284684I2D: score=1 STRING: ENSP00000228468
    STOML1Q9UBI43, ENSP000003193234I2D: score=1 STRING: ENSP00000319323
    STOMP271053, ENSP000002867134I2D: score=2 STRING: ENSP00000286713
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001101response to acid IEA--
    GO:0003026regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback IEA--
    GO:0006812cation transport ----
    GO:0006814sodium ion transport ----
    GO:0007268synaptic transmission TAS8626462

    ASIC2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ASIC2

    5 IUPHAR Ligands for ASIC2 (ASIC2)    About this table
    LigandTypeActionAffinityPubmed IDs
    H+ (extracellular)
    ActivatorNone4.1 - 5--
    amiloride
    Channel blockerNone4.6--
    A317567
    Channel blockerNone4.5--
    nafamostat
    Channel blockerNone4.2--
    Cd2+
    Channel blockerNone3--

    5 Novoseek inferred chemical compound relationships for ASIC2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    amiloride 78.2 10 10336442 (5), 17878160 (1), 9545267 (1), 9525939 (1)
    fmrfamide 67.7 2 9545267 (1)
    sodium 65.6 23 9037075 (2), 9886053 (1), 12584187 (1), 19561078 (1) (see all 19)
    hydrogen 13.2 4 19654327 (2), 9886053 (1)
    calcium 0 1 11514582 (1)



    ASIC2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ASIC2 gene (2 alternative transcripts): 
    NM_001094.4  NM_183377.1  

    Unigene Cluster for ASIC2:

    Acid-sensing (proton-gated) ion channel 2
    Hs.368417  [show with all ESTs]
    Unigene Representative Sequence: NM_183377
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000225823(uc002hht.3) ENST00000359872(uc002hhu.3) ENST00000448983
    ENST00000579816 ENST00000583395

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    Additional mRNA sequence: 

    AK127748.1 AK313043.1 AL834182.1 BC075042.2 BC075043.2 U50352.1 U53212.1 U57352.1 

    3 DOTS entries:

    DT.99946309  DT.441709  DT.75141496 

    Selected AceView cDNA sequences (see all 29):

    BU739497 BI821247 CD672292 NM_183377 AK127748 T16341 F04549 BV198467 
    AL834182 BM695413 BI823745 Z45660 BX109621 BU733480 BV206678 AI825456 
    U53212 AV750543 BC075043 BC075042 NM_001094 U50352 U57352 H12216 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ASIC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ASIC2 Expression
    About this image

    ASIC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ASIC2 Protein Expression

    Genevestigator expression for ASIC2

    SOURCE GeneReport for Unigene cluster: Hs.368417

    UniProtKB/Swiss-Prot: ASIC2_HUMAN, Q16515
    Tissue specificity: Brain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ASIC2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Asic21 , 5 amiloride-sensitive cation channel 1, neuronal (degenerin)5
    acid-sensing (proton-gated) ion channel 21
    92.78(n)1
    97.16(a)1
      11 (48.43 cM)5
    114181  NM_007384.31  NP_031410.11 
     808801695 
    chicken
    (Gallus gallus)
    Aves ASIC26
    acid-sensing (proton-gated) ion channel 2
    94(a)
    1 ↔ 1
    27(1768088-1844661) ENSGALG00000000367
    lizard
    (Anolis carolinensis)
    Reptilia ASIC26
    acid-sensing (proton-gated) ion channel 2
    92(a)
    1 ↔ 1
    6(71790428-71889012)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.147862 Xenopus laevis transcribed sequence with moderate similarity more 80(n)    BM179440.1 
    zebrafish
    (Danio rerio)
    Actinopterygii asic26
    acid-sensing (proton-gated) ion channel 2
    70(a)
    1 ↔ 1
    3(37819050-38623329) ENSDARG00000006849


    ENSEMBL Gene Tree for ASIC2 (if available)
    TreeFam Gene Tree for ASIC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ASIC2 gene
    SCNN1B2  ASIC32  SCNN1G2  SCNN1A2  ASIC42  SCNN1D2  ASIC52  ASIC12  
    4 SIMAP similar genes for ASIC2 using alignment to 1 protein entry:     ASIC2_HUMAN:
    ASIC1    ASIC3    ASIC4    ASIC5

    ASIC2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ASIC2 (see all 24794)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs600110971,2
    C--31339855(+) TCCAG-/GGCAGCC 2 -- ds50010--------
    rs607618851,2
    C--31343994(+) GCTGA-/CCCCAGC 2 -- int11Minor allele frequency- CC:0.00NA 2
    rs679420291,2
    C--31345304(+) GATAC-/CCCTGC
    ATCCAACTC
    TCCTG
    2 -- int10--------
    rs105784151,2
    C--31346814(+) GTATG-/TCTCTCT 2 -- int1 trp30--------
    rs560736591,2
    C--31346815(+) TCTCT-/CTCTCTC 2 -- int12Minor allele frequency- CT:0.00NA CSA 4
    rs580428731,2
    C--31355227(+) TCCCAG/-GGGCC 2 -- int13Minor allele frequency- -:0.00NA CSA 10
    rs2001728541,2
    C--31364167(-) CAATTC/TTTTTT 2 -- int10--------
    rs98935491,2
    C,F--31391182(+) tcgtcA/Gaagtc 2 -- int12Minor allele frequency- G:0.00NA 4
    rs98999261,2
    C,F,A--31391360(+) tggtgC/Tggctg 2 -- int11Minor allele frequency- T:0.50CSA 2
    rs98931711,2
    C,F,A--31391363(+) tgtggC/Atgtcc 2 -- int11Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for ASIC2 (31340105 - 31590105 bp, first 250kb of ASIC2)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ASIC2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ASIC2
    DNA2.0 Custom Variant and Variant Library Synthesis for ASIC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601784    OMIM disorders: --

    14 diseases for ASIC2:    About MalaCards
    neuronitis    panic disorder    adenoid cystic carcinoma    adenoiditis
    purpura    narcolepsy    hypothyroidism    malignant glioma
    bipolar disorder    cystic fibrosis    coronary artery disease    multiple sclerosis
    obesity    pancreatitis


    ASIC2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    3 Novoseek inferred disease relationships for ASIC2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioma 29.1 23 17878160 (6), 12584187 (3), 16704974 (3), 19561078 (2) (see all 5)
    neurodegeneration 6.57 3 8631835 (2)
    tumors 0 4 12957380 (2), 12584187 (1)


    Export disorders for ASIC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ASIC2 gene, integrated from 10 sources (see all 102):
    (articles sorted by number of sources associating them with ASIC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels. (PubMed id 9037075)1, 2, 9 Garcia-Anoveros J....Corey D.P. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    2. Mammalian ASIC2a and ASIC3 subunits co-assemble into heteromeric proton-gated channels sensitive to Gd3+. (PubMed id 10842183)1, 2, 9 Babinski K.... Seguela P. (J. Biol. Chem. 2000)
    3. Cloning and expression of a novel human brain Na+ channel. (PubMed id 8626462)1, 2, 9 Price M.P.... Welsh M.J. (J. Biol. Chem. 1996)
    4. The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans. (PubMed id 8631835)1, 2, 9 Waldmann R.... Lazdunski M. (J. Biol. Chem. 1996)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel). (PubMed id 11802773)1, 2 Hruska-Hageman A.M.... Welsh M.J. (Biochem. J. 2002)
    7. The human degenerin MDEG, an amiloride-sensitive neuronal cation channel, is localized on chromosome 17q11.2-17q12 close to the microsatellite D17S798. (PubMed id 8921408)1, 3 Waldmann R....Lazdunski M. (Genomics 1996)
    8. Association between the ACCN1 gene and multiple sclerosis in Central East Sardinia. (PubMed id 17534430)1, 9 Bernardinelli L....Berzuini C. (PLoS ONE 2007)
    9. Surface expression of ASIC2 inhibits the amiloride-sensitive current and migration of glioma cells. (PubMed id 16704974)1, 9 Vila-Carriles W.H....Benos D.J. (J. Biol. Chem. 2006)
    10. The acid-sensitive ionic channel subunit ASIC and the mammalian degenerin MDEG form a heteromultimeric H+-gated Na+ channel with novel properties. (PubMed id 9360943)1, 9 Bassilana F....Lazdunski M. (J. Biol. Chem. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 40 HGNC: 99 AceView: ACCN1 Ensembl:ENSG00000108684 euGenes: HUgn40
    ECgene: ASIC2 Kegg: 40 H-InvDB: ASIC2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ASIC2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ASIC2 gene:
    Search GeneIP for patents involving ASIC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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