Aliases for ASH2L Gene
Aliases for ASH2L Gene
External Ids for ASH2L Gene
- HGNC: 744
- Entrez Gene: 9070
- Ensembl: ENSG00000129691
- OMIM: 604782
- UniProtKB: Q9UBL3
Previous HGNC Symbols for ASH2L Gene
- ASH2L1
Previous GeneCards Identifiers for ASH2L Gene
- GC08M037436
- GC08P038091
- GC08P037704
- GC08P037980
- GC08P038082
- GC08P037963
- GC08P036498
Summaries for ASH2L Gene
GeneCards Summary for ASH2L Gene
ASH2L (ASH2 Like Histone Lysine Methyltransferase Complex Subunit) is a Protein Coding gene. Diseases associated with ASH2L include Kabuki Syndrome 1. Among its related pathways are Signaling by Wnt and Signaling by GPCR. GO annotations related to this gene include transcription regulatory region DNA binding and histone methyltransferase activity (H3-K4 specific).
UniProtKB/Swiss-Prot for ASH2L Gene
-
Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates Lys-4 of histone H3, but not if the neighboring Lys-9 residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at Lys-4 of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASH2L Gene
Genomics for ASH2L Gene
Regulatory Elements for ASH2L Gene
Enhancers for ASH2L Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH08G038056 | 1.4 | Ensembl ENCODE dbSUPER | 11.8 | -46.8 | -46800 | 2.6 | ARID4B ZNF2 ZNF121 GATA2 ZNF143 FOS DEK ZNF263 REST MYNN | ASH2L GOT1L1 RNU6-323P ENSG00000260949 GC08P038040 |
| GH08G038029 | 1.4 | ENCODE dbSUPER | 11.2 | -73.9 | -73862 | 3.9 | HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZNF143 FOS KLF13 | RPS20P22 LOC102723716 ASH2L RNU6-323P GOT1L1 EIF4EBP1 GC08P038040 |
| GH08G038024 | 1 | ENCODE | 11.2 | -80.1 | -80138 | 0.3 | HDGF ATF1 PKNOX1 ZNF2 TCF12 GATA2 ZNF143 TBX21 ZNF592 CREB3 | ASH2L RNU6-323P GOT1L1 EIF4EBP1 GC08P037988 |
| GH08G038089 | 1.8 | FANTOM5 Ensembl ENCODE dbSUPER | 3.5 | -13.4 | -13420 | 4.7 | HDGF PKNOX1 ARNT YY1 ZNF766 KLF13 REST ZNF592 KAT8 MEF2D | ASH2L ENSG00000272128 ENSG00000260949 |
| GH08G038059 | 0.5 | dbSUPER | 11.8 | -44.8 | -44784 | 0.9 | CTCF RB1 HLF CEBPB REST | ASH2L GOT1L1 RNU6-323P ENSG00000260949 GC08P038040 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ASH2L on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the ASH2L gene promoter:
Regulatory Element Products
Genomic Location for ASH2L Gene
- Chromosome:
- 8
- Start:
- 38,104,965 bp from pter
- End:
- 38,144,076 bp from pter
- Size:
- 39,112 bases
- Orientation:
- Plus strand
Genomic View for ASH2L Gene
Genes around ASH2L on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8p11.23 by Ensembl
- 8p11.23 by Entrez Gene
- 8p11.23 by HGNC
ASH2L Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ASH2L Gene
Proteins for ASH2L Gene
-
Protein details for ASH2L Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UBL3-ASH2L_HUMAN
- Recommended name:
- Set1/Ash2 histone methyltransferase complex subunit ASH2
- Protein Accession:
- Q9UBL3
- A8K7C3
- D3DSW9
- O60659
- O60660
- Q96B62
Protein attributes for ASH2L Gene
- Size:
- 628 amino acids
- Molecular mass:
- 68723 Da
- Quaternary structure:
-
- Interacts with HCFC1. Core component of several methyltransferase-containing complexes including MLL1/MLL, MLL2/3 (also named ASCOM complex) and MLL4/WBP7. Each complex is at least composed of ASH2L, RBBP5, WDR5, DPY30, one or more specific histone methyltransferases (KMT2A/MLL1, KMT2D/MLL2, KMT2C/MLL3 and KMT2B/MLL4), and the facultative components PAGR1, BAP18, CHD8, E2F6, HCFC1, HCFC2, HSP70, INO80C, KDM6A, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, KAT8/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9, TEX10 and alpha- and beta-tubulin. Interacts with DPY30 and RBBP5; the interaction is direct. Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Interacts with SETD1A and SETD1B.
Three dimensional structures from OCA and Proteopedia for ASH2L Gene
Protein Expression for ASH2L Gene
Post-translational modifications for ASH2L Gene
- Both monomethylated and dimethylated on arginine residues in the C-terminus. Arg-296 is the major site. Methylation is not required for nuclear localization, nor for MLL complex integrity or maintenance of global histone H3K4me3 levels.
- Ubiquitination at posLast=338338
- Modification sites at PhosphoSitePlus
Other Protein References for ASH2L Gene
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for ASH2L
- Cell Signaling Technology (CST) Antibodies for ASH2L (ASH2L)
- Novus Biologicals Antibodies for ASH2L
-
Abcam antibodies for ASH2L
- Invitrogen Antibodies for ASH2L
- antibodies-online Antibodies for ASH2L: See all 59
- GeneTex ASH2L antibody for ASH2L
-
Santa Cruz Biotechnology (SCBT) Antibodies for ASH2L
Protein Products
-
OriGene Purified Proteins for ASH2L
- Search Origene for MassSpec and Protein Over-expression Lysates for ASH2L
- Origene Custom Protein Services for ASH2L
- antibodies-online Proteins for ASH2L: See all 6
- Search antibodies-online for peptides
- Search GeneTex for Proteins for ASH2L
-
Abcam proteins for ASH2L
Assay Products
- antibodies-online Kits for ASH2L: See all 21
No data available for DME Specific Peptides for ASH2L Gene
Domains & Families for ASH2L Gene
Gene Families for ASH2L Gene
- HGNC:
Protein Domains for ASH2L Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ASH2L Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for ASH2L Gene
Function for ASH2L Gene
Molecular function for ASH2L Gene
- GENATLAS Biochemistry:
- Drosophila ASH2 (absent,small or homeotic discs 2)-like,maintaining chromatin in a transcriptionally active information,ubiquitously expressed,predominantly in heart,testis,fetal lung,fetal liver
- UniProtKB/Swiss-Prot Function:
- Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates Lys-4 of histone H3, but not if the neighboring Lys-9 residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at Lys-4 of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IC | 10393421 |
| GO:0005515 | protein binding | IPI | 12482968 |
| GO:0008013 | beta-catenin binding | IDA | 22723415 |
| GO:0018024 | histone-lysine N-methyltransferase activity | TAS | -- |
| GO:0042800 | contributes_to histone methyltransferase activity (H3-K4 specific) | IDA | 17355966 |
Phenotypes for ASH2L Gene
- MGI mutant phenotypes for ASH2L:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ASH2L:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ASH2L
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ASH2L gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ASH2L gene
- Search ViGene Biosciences for ASH2L
CRISPR Products
-
OriGene CRISPR knockouts for ASH2L
-
Santa Cruz Biotechnology (SCBT) CRISPR for ASH2L
- GenScript: Design CRISPR guide RNA sequences for ASH2L
miRNA for ASH2L Gene
- miRTarBase miRNAs that target ASH2L
-
- hsa-mir-1-3p (MIRT001383)
- hsa-mir-877-3p (MIRT036952)
- hsa-mir-125b-2-3p (MIRT038629)
- hsa-mir-5089-5p (MIRT509378)
- hsa-mir-6807-5p (MIRT509379)
- hsa-mir-5589-5p (MIRT509380)
- hsa-mir-4731-5p (MIRT509381)
- hsa-mir-6506-5p (MIRT509382)
- hsa-mir-619-5p (MIRT509383)
- hsa-mir-372-5p (MIRT509384)
- hsa-mir-371a-5p (MIRT509385)
- hsa-mir-616-5p (MIRT509386)
- hsa-mir-373-5p (MIRT509387)
- hsa-mir-371b-5p (MIRT509388)
- hsa-mir-4698 (MIRT509389)
- hsa-mir-8063 (MIRT509390)
- hsa-mir-449b-3p (MIRT509391)
- hsa-mir-580-3p (MIRT628735)
- hsa-mir-6770-5p (MIRT628736)
- hsa-mir-1253 (MIRT628737)
miRNA Products
- Search ViGene Biosciences for ASH2L
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ASH2L
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ViGene Biosciences ready-to-package AAV shRNAs for ASH2L gene
Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for ASH2L gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ASH2L gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ASH2L Gene
Localization for ASH2L Gene
Subcellular locations from UniProtKB/Swiss-Prot for ASH2L Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 2 |
| cytosol | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IMP | 22723415 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005719 | nuclear euchromatin | IEA | -- |
| GO:0035097 | histone methyltransferase complex | IPI | 14992727 |
| GO:0044666 | MLL3/4 complex | IDA | 17500065 |
Pathways & Interactions for ASH2L Gene
Pathways by source for ASH2L Gene
1 Cell Signaling Technology pathway for ASH2L Gene
Interacting Proteins for ASH2L Gene
Selected Interacting proteins:
ENSP00000340896
Q9UBL3-ASH2L_HUMAN
for ASH2L Gene via
STRING
IID
MINT
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | NAS | 10393421 |
| GO:0006355 | regulation of transcription, DNA-templated | NAS | 10393421 |
| GO:0006366 | transcription from RNA polymerase II promoter | TAS | 10393421 |
| GO:0006974 | cellular response to DNA damage stimulus | IDA | 17500065 |
| GO:0008284 | positive regulation of cell proliferation | IMP | 18245475 |
Transcripts for ASH2L Gene
mRNA/cDNA for ASH2L Gene
- (8) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (278) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ASH2L Gene
- Ash2 (absent, small, or homeotic)-like (Drosophila):
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for ASH2L
-
Santa Cruz Biotechnology (SCBT) CRISPR for ASH2L
- GenScript: Design CRISPR guide RNA sequences for ASH2L
miRNA Products
- Search ViGene Biosciences for ASH2L
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ASH2L
- Browse OriGene Inhibitory RNA Products For ASH2L
-
ViGene Biosciences ready-to-package AAV shRNAs for ASH2L gene
Clone Products
- Sino Biological Human cDNA Clone for ASH2L
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for ASH2L
- VectorBuilder custom plasmid, inducible vectors for ASH2L
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ASH2L
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP6: |
Expression for ASH2L Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
-
Limb (Muscoskeletal System)
- Limb Bud Mesenchyme Cells Limb Bud
-
Mesoderm (Gastrulation Derivatives)
- Limb Bud Mesenchyme Cells Limb Bud
- Ovary (Reproductive System)
This gene is overexpressed in Lymph node (15.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ASH2L Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ASH2L Gene:
ASH2LSOURCE GeneReport for Unigene cluster for ASH2L Gene:
Hs.521530mRNA Expression by UniProt/SwissProt for ASH2L Gene:
Q9UBL3-ASH2L_HUMAN
Tissue specificity:
Ubiquitously expressed. Predominantly expressed in adult heart and testis and fetal lung and liver, with barely detectable expression in adult lung, liver, kidney, prostate, and peripheral leukocytes.
Evidence on tissue expression from TISSUES for ASH2L Gene
- Nervous system(4.9)
- Skin(4.2)
- Kidney(2.2)
Primer Products
-
OriGene qPCR primer pairs for ASH2L
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ASH2L Gene
Orthologs for ASH2L Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ASH2L 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ASH2L 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ASH2L 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ASH2L 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | ASH2L 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ash2l 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Ash2l 34 16 35 |
|
||
| chicken (Gallus gallus) |
Aves | ASH2L 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ASH2L 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ash2l 34 |
|
||
| Str.8406 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.33564 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ash2l 34 35 |
|
||
| wufi20h02 34 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003705 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | ash2 36 34 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | ash-2 34 35 |
|
||
| Y17G7B.2a 36 |
|
|
|||
| Y17G7B.2b 36 |
|
|
|||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToOne | |
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | ash2 34 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.12291 34 |
|
- Species where no ortholog for ASH2L was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ASH2L Gene
Pseudogenes.org Pseudogenes for ASH2L Gene
No data available for Paralogs for ASH2L Gene
Variants for ASH2L Gene
| SNP ID | Clin | Chr 08 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000015496 | -- | 38,133,384(+) | GTGTG(C/T)GGATG | intron-variant | |
| rs1000151866 | -- | 38,113,914(+) | GGACT(A/G)TGACA | intron-variant | |
| rs1000154867 | -- | 38,126,397(+) | AGGGG(A/T)TATTA | intron-variant | |
| rs1000267002 | -- | 38,109,102(+) | TAAAG(A/C/T)CCAGT | intron-variant | |
| rs1000290910 | -- | 38,130,562(+) | ATGGT(A/G)TTAGC | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3616917 | CNV | gain | 21293372 |
| esv3616918 | CNV | gain | 21293372 |
Residual Variation Intolerance Score:
31.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.25;
40.40% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ASH2L Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASH2L Gene
Disorders for ASH2L Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| kabuki syndrome 1 |
|
|
Search ASH2L in MalaCards
View complete list of genes associated with diseases
Relevant External Links for ASH2L
No data available for UniProtKB/Swiss-Prot and Genatlas for ASH2L Gene
Publications for ASH2L Gene
- Cloning and characterization of ASH2L and ash2l, human and mouse homologs of the Drosophila ash2 gene. (PMID: 10393421) Ikegawa S. … Nakamura Y. (Cytogenet. Cell Genet. 1999) 2 3 4 22 64
- Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding. (PMID: 21660059) Chen Y. … Lei M. (EMBO Rep. 2011) 2 3 4 64
- ASH2L: alternative splicing and downregulation during induced megakaryocytic differentiation of multipotential leukemia cell lines. (PMID: 11466562) Wang J. … Qiang B. (J. Mol. Med. 2001) 3 4 22 64
- Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. (PMID: 22267201) Stolk L. … Lunetta K.L. (Nat. Genet. 2012) 3 46 64
- Protein-arginine methyltransferase 1 (PRMT1) methylates Ash2L, a shared component of mammalian histone H3K4 methyltransferase complexes. (PMID: 21285357) Butler J.S. … Dent S.Y. (J. Biol. Chem. 2011) 3 4 64
Products for ASH2L Gene
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- Novus Biologicals Tissue Microarrays
- Abcam antibodies for ASH2L
- Abcam proteins for ASH2L
- Search for Assays for ASH2L at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- Addgene plasmids for ASH2L
- antibodies-online Antibodies for ASH2L: See all 59
- antibodies-online Kits for ASH2L: See all 21
- antibodies-online Proteins for ASH2L: See all 6
- Search antibodies-online for peptides
- GeneTex ASH2L antibody for ASH2L
- Search GeneTex for Proteins for ASH2L
- ViGene Biosciences adenoviral particle packaged cDNA for ASH2L gene
- ViGene Biosciences lentiviral particle packaged cDNA for ASH2L gene
- ViGene Biosciences ready-to-package AAV shRNAs for ASH2L gene
- Search ViGene Biosciences for ASH2L
- Santa Cruz Biotechnology (SCBT) Antibodies for ASH2L
- Search Santa Cruz Biotechnology (SCBT) for ASH2L siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ASH2L
- Cyagen custom Knockout/knockin (KOKI) mouse models for ASH2L
- VectorBuilder custom plasmid, inducible vectors for ASH2L
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ASH2L
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ASH2L Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer