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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ASH1L Gene

protein-coding GIFtS: 59
GCID: GC01M155305

ash1 (absent, small, or homeotic)-like (Drosophila)

Explore 4 diseases affiliated with
ASH1L via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ash1 (Absent, Small, Or Homeotic)-Like (Drosophila)¹ ²		Lysine N-Methyltransferase 2H² ³
KMT2H¹ ² ³		ASH1-Like Protein² ³
ASH1¹ ²		EC 2.1.1.43³ ⁸
ASH1L1¹ ²		Histone-Lysine N-Methyltransferase ASH1L²
HuASH1¹		Probable Histone-Lysine N-Methyltransferase ASH1L²
Absent Small And Homeotic Disks Protein 1 Homolog² ³		KIAA1420³

External Ids:	HGNC: 19088¹	Entrez Gene: 55870²	Ensembl: ENSG00000116539⁷	OMIM: 607999⁵	UniProtKB: Q9NR48³

Export aliases for ASH1L gene to outside databases

Previous GC identifers: GC01M152084 GC01M152523 GC01M152119 GC01M153571 GC01M126666

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ASH1L:

This gene encodes a member of the trithorax group of transcriptional activators. The protein contains four AT hooks, a

SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles in the nucleus, and also to

cell-cell tight junctions. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ASH1L_HUMAN, Q9NR48

Function: Histone methyltransferase specifically methylating 'Lys-36' of histone H3 (H3K36me)

Gene Wiki entry for ASH1L

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ASH1L gene promoter:
AML1a NCX/Ncx Olf-1 Ik-3 YY1 AREB6 S8 COMP1 En-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ASH1L promoter sequence

Search SABiosciences Chromatin IP Primers for ASH1L

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASH1L

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22 Ensembl cytogenetic band: 1q22 HGNC cytogenetic band: 1q22

ASH1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASH1L gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M155305: view genomic region (about GC identifiers)

Start:	155,305,052 bp from pter	End:	155,532,598 bp from pter
Size:	227,547 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ASH1L_HUMAN, Q9NR48 (See protein sequence)

Recommended Name: Histone-lysine N-methyltransferase ASH1L

Size: 2969 amino acids; 332790 Da

Subcellular location: Nucleus. Cell junction, tight junction. Chromosome (Probable). Note=The relevance of tight

junction localization is however unclear

Sequence caution: Sequence=BAA92658.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

2 PDB 3D structures from and Proteopedia for ASH1L:

3MQM (3D)

3OPE (3D)

Secondary accessions: Q59GP1 Q5T714 Q5T715 Q9P2C7

Alternative splicing: 2 isoforms: Q9NR48-1 Q9NR48-2

Explore the universe of human proteins at neXtProt for ASH1L: NX_Q9NR48

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NR48

2 DME Specific Peptides for ASH1L (Q9NR48)

NHSCDPN

QKWSVNG

ASH1L Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_060959.2

ENSEMBL proteins:

ENSP00000357330 ENSP00000376204 ENSP00000448820 ENSP00000449283

Human Recombinant Protein Products:

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	Uscn Proteins for ASH1L

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005694	chromosome	IEA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0005794	Golgi apparatus	IDA	--

ASH1L for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for ASH1L

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ASH1L for domains About GeneDecksing

5/11 InterPro domains/families (see all 11):

IPR017956 AT_hook_DNA-bd_motif

IPR001214 SET_dom

IPR019786 Zinc_finger_PHD-type_CS

IPR001965 Znf_PHD

IPR003616 Post-SET_dom

Graphical View of Domain Structure for InterPro Entry Q9NR48

ProtoNet protein and cluster: Q9NR48

5 Blocks protein families:

IPB001025 Bromo adjacent region

IPB001214 Nuclear protein SET

IPB001487 Bromodomain signature

IPB001965 Zn-finger-like

IPB003616 SET-related region

UniProtKB/Swiss-Prot: ASH1L_HUMAN, Q9NR48

Similarity: Belongs to the histone-lysine methyltransferase family. SET2 subfamily

Similarity: Contains 3 A.T hook DNA-binding domains

Similarity: Contains 1 AWS domain

Similarity: Contains 1 BAH domain

Similarity: Contains 1 bromo domain

Similarity: Contains 1 PHD-type zinc finger

Similarity: Contains 1 post-SET domain

Similarity: Contains 1 SET domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ASH1L_HUMAN, Q9NR48

Function: Histone methyltransferase specifically methylating 'Lys-36' of histone H3 (H3K36me)

Catalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine +

N(6)-methyl-L-lysine-[histone]

Enzyme Number (IUBMB): EC 2.1.1.43¹ ²

miRNA Products:		OriGene 3'-UTR Clone: ASH1L Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ASH1L
		8/127 QIAGEN miScript miRNA Assays for microRNAs that regulate ASH1L (see all 127):
		hsa-miR-520e hsa-miR-520f hsa-miR-631 hsa-miR-15a hsa-miR-106a hsa-miR-1224-3p hsa-miR-1258 hsa-miR-1260b

		SwitchGear 3'UTR luciferase reporter plasmid: ASH1L 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASH1L

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0018024	histone-lysine N-methyltransferase activity	IEA	--

ASH1L for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Lysine degradation

Lysine degradation

1.00

Tight junction

Tight junction

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Kegg Pathways (Kegg details for ASH1L):

	Lysine degradation
	Tight junction

ASH1L for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ASH1L

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/23 Interacting proteins for ASH1L (Q9NR48^{2, 3} ENSP00000376204⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 23)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H3A	P68431³, ENSP00000350275⁴	I2D: score=1 STRING: ENSP00000350275
HIST1H3B	P68431³	I2D: score=1
HIST1H3C	P68431³	I2D: score=1
HIST1H3D	P68431³	I2D: score=1
HIST1H3E	P68431³	I2D: score=1

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006323	DNA packaging	TAS	10860993
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0006366	transcription from RNA polymerase II promoter	TAS	10860993
GO:0007267	cell-cell signaling	TAS	10860993

ASH1L for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ASH1L

2 HMDB Compounds for ASH1L About this table

Compound	Synonyms	CAS #	PubMed Ids
S-Adenosylhomocysteine	(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)	979-92-0	--
S-Adenosylmethionine	(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)	29908-03-0	--

Search CenterWatch for drugs/clinical trials and news about ASH1L

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ASH1L gene:

NM_018489.2

Unigene Cluster for ASH1L:

Ash1 (absent, small, or homeotic)-like (Drosophila)

Hs.491060 [show with all ESTs]

Unigene Representative Sequence: NM_018489

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000368346(uc001fkt.3 uc009wqq.3) ENST00000392403(uc009wqr.1)

ENST00000478837 ENST00000548566 ENST00000492987 ENST00000477427 ENST00000548830

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ASH1L
		8/127 QIAGEN miScript miRNA Assays for microRNAs that regulate ASH1L (see all 127):
		hsa-miR-520e hsa-miR-520f hsa-miR-631 hsa-miR-15a hsa-miR-106a hsa-miR-1224-3p hsa-miR-1258 hsa-miR-1260b

		SwitchGear 3'UTR luciferase reporter plasmid: ASH1L 3' UTR sequence

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		GenScript: all cDNA clones in your preferred vector: ASH1L (NM_018489)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASH1L

Additional cDNA sequence:

AB037841.1 AB209068.1 AF257305.1 AK304873.1 AK307595.1

10 DOTS entries:

DT.311859 DT.121325505 DT.445679 DT.91944132 DT.100736217 DT.121325586 DT.91662732 DT.92429463

DT.95111078 DT.95166612

24/204 AceView cDNA sequences (see all 204):

AI298692 BM557494 BM055353 BM055069 CA429968 BM126034 CK822178 AA258614

AI806500 CA309925 BQ220997 AW304108 BM127569 N24669 H93054 AI457361

AA815030 AA713968 AI640746 AW196332 BX106765 NM_018489 N35460 AA401801

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ASH1L (see all 7) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8a	·	8b	·	8c	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21a	·	21b	^	22	^
SP1:																																																			-
SP2:																	-
SP3:																	-
SP4:																																																			-
SP5:

ExUns:	23a	·	23b	^	24	^	25a	·	25b	·	25c	^	26	^	27	^	28a	·	28b	^	29
SP1:	-										-
SP2:
SP3:
SP4:	-
SP5:

ECgene alternative splicing isoforms for ASH1L

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ASH1L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTGTAGGCT

About this image

ASH1L expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Reproductive System

Early Gonad

Testis Somatic Cells

Testis

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ASH1L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ASH1L

SOURCE GeneReport for Unigene cluster: Hs.491060

UniProtKB/Swiss-Prot: ASH1L_HUMAN, Q9NR48

Tissue specificity: Widely expressed, with highest level in brain, heart and kidney

SABiosciences Expression via Pathway-Focused PCR Arrays including ASH1L:

Epigenetic Chromatin Modification Enzymes in human mouse rat

Tight Junctions in human mouse rat

Amino Acid Metabolism II in human mouse rat

Polycomb & Trithorax Complexes in human mouse rat

Cardiotoxicity in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASH1L

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ASH1L gene from 7/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ASH1L¹	ash1 (absent, small, or homeotic)-like (Drosophila)	75.56(n) 80.92(a)		425064 XM_422858.3 XP_422858.3
lizard (Anolis carolinensis)	Reptilia	NSD1⁶	--	8(a)	1 ↔ 1	2(145380212-145417378)
African clawed frog (Xenopus laevis)	Amphibia	Xl.4459²	Xenopus laevis transcribed sequence with moderate similarity more	76.87(n)		BJ618203.1
zebrafish (Danio rerio)	Actinopterygii	wufi34d11²	Transcribed sequence with moderate similarity to protein more	75.67(n)		57065548
worm (Caenorhabditis elegans)	Secernentea	lin-59⁶ set-12⁶	Probable histone-lysine N-methyltransferase lin-59... SET (trithorax/polycomb) domain containing family ...	7(a) 18(a)	possible ortholog possible ortholog	I(3713520-3721160) X(7733288-7736219)
thale cress (Arabidopsis thaliana)	eudicotyledons	LAZ2⁶ SDG26⁶	histone-lysine N-methyltransferase ASHH1	8(a) 15(a)	1 ↔ 1 possible ortholog	1(29039922-29049302) 1(28789729-28792676)
rice (Oryza sativa)	Liliopsida	-- -- (see all 3)	SET domain containing protein (see all 3)	16(a) 13(a) (see all 3)	possible ortholog possible ortholog (see all 3)	4(21086102-21090883) 8(21566227-21574660)

ENSEMBL Gene Tree for ASH1L (if available)
TreeFam Gene Tree for ASH1L (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ASH1L gene

SETBP1²

4 SIMAP similar genes for ASH1L using alignment to 3 protein entries: ASH1L_HUMAN (see all proteins):

FAM175A MLL5 SETBP1 FP13812

ASH1L for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs6677385^1,2	C,F,A,H,	--	155304581(+)	`AAAAAA/CCCAAC`	1	--	ds500¹		10		NA WA CSA EA	371
rs147078872^1,2		--	155304603(+)	`ACTACA/GTTAGG`	1	--	ds500¹		0	--	--	--	--
rs138491944^1,2		--	155304714(+)	`ATCATC/TTGAGT`	1	--	ds500¹		0	--	--	--	--
rs183606140^1,2		--	155304753(+)	`GATTGC/TGCCAT`	1	--	ds500¹		0	--	--	--	--
rs144047582^1,2		--	155304790(+)	`ACTCTA/GTCTCA`	1	--	ds500¹		0	--	--	--	--
rs73006942^1,2	C,	--	155304842(+)	`TATTAC/TTGTGC`	1	--	ds500¹		1		WA	2
rs190192552^1,2		--	155304862(+)	`AGGCTA/GAGTCC`	1	--	ds500¹		0	--	--	--	--
rs77526494^1,2		--	155304886(+)	`CCTAGT/CACTGA`	1	--	ds500¹		1		NA	120
rs6695298^1,2	C,H	--	155305059(+)	`CACAGT/GTAGGA`	1	--	ut3¹		6		NS EA NA	416
rs11552268^1,2	C	--	155305290(+)	`TGCAGT/GGATGT`	1	--	ut3¹ ese³		2		NA	4

HapMap Linkage Disequilibrium report for ASH1L (155305052 - 155532598 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for ASH1L
3 CNVs: 97516 3315 6789

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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ASH1L for disorders           About GeneDecksing

OMIM gene information: 607999    OMIM disorders: --

4 diseases for ASH1L:    About MalaCards

facioscapulohumeral muscular dystrophy muscular dystrophy homocysteine malaria

1 disease from the University of Copenhagen DISEASES database for ASH1L:

Facioscapulohumeral muscular dystrophy

Export disorders for ASH1L gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ASH1L gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with ASH1L)

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huASH1 protein, a putative transcription factor encoded by a human homologue of the Drosophila ash1 gene, localizes to both nuclei and cell-cell tight junctions. (PubMed id 10860993)^{1, 2, 3, 9} Nakamura T.... Canaani E. (2000)
Crystal structure of the human histone methyltransfer ase ASH1L catalytic domain and its implications for the regulatory mechanism. (PubMed id 21239497)^{1, 2} An S....Song J.J. (2011)
The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells. (PubMed id 17203973)^{1, 2} Vasilescu J.... Figeys D. (2007)
An anthropoid-specific segmental duplication on human chromosome 1q22. (PubMed id 16545939)^{1, 3} Kuryshev V.Y....Wiemann S. (2006)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)^{1, 2} Nagase T.... Ohara O. (2000)
A long ncRNA links copy number variation to a polycomb /trithorax epigenetic switch in FSHD muscular dystrophy. (PubMed id 22541069)¹ Cabianca D.S....Gabellini D. (2012)
Histone recognition and large-scale structural analysis of the human bromodomain family. (PubMed id 22464331)² Filippakopoulos P.... Knapp S. (2012)
The global gene-expression profiles of U-937 human mac rophages treated with Tat peptide and Tat-FITC conjugate. (PubMed id 22632162)¹ Lin C.W....Jan M.S. (2012)
Dual function of histone H3 lysine 36 methyltransferas e ASH1 in regulation of Hox gene expression. (PubMed id 22140534)¹ Tanaka Y....Kioussis D. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 55870	HGNC: 19088	AceView: ASH1L	Ensembl:ENSG00000116539	euGenes: HUgn55870
ECgene: ASH1L	Kegg: 55870	H-InvDB: ASH1L

(According to HUGE)
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HUGE: KIAA1420

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ASH1L	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ASH1L gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ASH1L gene:
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ASH1L Gene

ash1 (absent, small, or homeotic)-like (Drosophila)

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ASH1L Gene

ash1 (absent, small, or homeotic)-like (Drosophila)

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