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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ASGR2 Gene

protein-coding   GIFtS: 61
GCID: GC17M007004

Asialoglycoprotein Receptor 2

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Asialoglycoprotein Receptor 21 2     ASGPR22
Hepatic Lectin H22 3     HBXBP2
CLEC4H22 3     HBxAg-Binding Protein2
HL-22 3     ASGP-R 23
C-Type Lectin Domain Family 4 Member H22 3     ASGPR 23
ASGP-R22     

External Ids:    HGNC: 7431   Entrez Gene: 4332   Ensembl: ENSG000001619447   OMIM: 1083615   UniProtKB: P073073   

Export aliases for ASGR2 gene to outside databases

Previous GC identifers: GC17M007393 GC17M007735 GC17M006949 GC17M007205 GC17M006945 GC17M006898


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ASGR2 Gene:
This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that
plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of
glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor
may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for
liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major
and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant
minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this
gene. (provided by RefSeq, Jan 2011)

GeneCards Summary for ASGR2 Gene: 
ASGR2 (asialoglycoprotein receptor 2) is a protein-coding gene. Diseases associated with ASGR2 include hepatitis b, and hepatitis, and among its related super-pathways are Insulin secretion. GO annotations related to this gene include carbohydrate binding and asialoglycoprotein receptor activity. An important paralog of this gene is CD207.

UniProtKB/Swiss-Prot: ASGR2_HUMAN, P07307
Function: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their
complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and
N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and
transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the
cell membrane surface




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ASGR2 gene promoter:
         COUP-TF1   COUP-TF   COUP   Nkx2-5   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidASGR2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ASGR2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASGR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p

ASGR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASGR2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M007004:  view genomic region     (about GC identifiers)

Start:
7,004,641 bp from pter      End:
7,019,019 bp from pter
Size:
14,379 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ASGR2_HUMAN, P07307 (See protein sequence)
Recommended Name: Asialoglycoprotein receptor 2  
Size: 311 amino acids; 35092 Da
Subunit: The functioning ligand-binding unit of this receptor is thought to be at least a dimer. Interacts with
LASS2
Subcellular location: Membrane; Single-pass type II membrane protein
Miscellaneous: Calcium is required for ligand binding
Secondary accessions: A6NLV8 A8MT12 D3DTM9 D3DTN0 O00448 Q03969
Alternative splicing: 3 isoforms:  P07307-1   P07307-2   P07307-3   

Explore the universe of human proteins at neXtProt for ASGR2: NX_P07307

Explore proteomics data for ASGR2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P07307

  • ASGR2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ASGR2 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001172.1  NP_001188281.1  NP_550434.1  NP_550435.1  NP_550436.1  

    ENSEMBL proteins: 
     ENSP00000347140   ENSP00000254850   ENSP00000405844   ENSP00000458835   ENSP00000370339  

    Human Recombinant Protein Products for ASGR2: 
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    Sino Biological Recombinant Protein for ASGR2
    Sino Biological Cell Lysate for ASGR2 
    ProSpec Recombinant Protein for ASGR2
    Cloud-Clone Corp. Proteins for ASGR2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    ASGR2 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for ASGR2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CLEC: C-type lectin domain containing

    5 InterPro protein domains:
     IPR016187 C-type_lectin_fold
     IPR018378 C-type_lectin_CS
     IPR016186 C-type_lectin-like
     IPR005640 Lectin_N
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry P07307

    ProtoNet protein and cluster: P07307

    2 Blocks protein domains:
    IPB002353 Type II antifreeze protein signature
    IPB005640 Hepatic lectin


    UniProtKB/Swiss-Prot: ASGR2_HUMAN, P07307
    Similarity: Contains 1 C-type lectin domain


    ASGR2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ASGR2_HUMAN, P07307
    Function: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their
    complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and
    N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and
    transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the
    cell membrane surface

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004873asialoglycoprotein receptor activity TAS3863106
    GO:0005515protein binding IPI11543633
    GO:0030246carbohydrate binding IEA--
         
    ASGR2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ASGR2:
     Decreased number of cells in m 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Asgr2):
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 

    ASGR2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Asgr2tm1Her for ASGR2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ASGR2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ASGR2

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    hsa-miR-3685 hsa-miR-4264
    SwitchGear 3'UTR luciferase reporter plasmidASGR2 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASGR2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ASGR2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Insulin secretion
    Thyroid hormone synthesis0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1         Kegg Pathway  (Kegg details for ASGR2):
        Thyroid hormone synthesis


    ASGR2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ASGR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/10 Interacting proteins for ASGR2 (P073071, 3 ENSP000003471404) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CERS2Q96G231, 3, ENSP000002716884EBI-1172636,EBI-1057080 I2D: score=3 STRING: ENSP00000271688
    ASGR1P073063, ENSP000002692994I2D: score=1 STRING: ENSP00000269299
    F8P004513, ENSP000003533934I2D: score=1 STRING: ENSP00000353393
    EDEM1ENSP000002564974STRING: ENSP00000256497
    ERLEC1ENSP000001851504STRING: ENSP00000185150
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166cell surface receptor signaling pathway TAS3863106
    GO:0009100glycoprotein metabolic process IEA--
    GO:0030282bone mineralization IEA--
    GO:0031647regulation of protein stability IEA--
    GO:0055088lipid homeostasis IEA--

    ASGR2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ASGR2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ASGR2

    1 HMDB Compound for ASGR2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for ASGR2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Antihemophilic FactorAHF (see all 3)--targetbinder17139284 15946216 17016423

    10/12 Novoseek inferred chemical compound relationships for ASGR2 gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pvla 87.3 9 11444822 (3), 14586135 (1), 16004427 (1), 16158256 (1)
    galactose 69.8 21 18855599 (2), 9555658 (2), 15885467 (2), 17931643 (1) (see all 15)
    sialic acid 42.4 2 17103087 (1), 9989767 (1)
    spec-t 36.9 1 14575385 (1)
    glycolipid 23.5 2 16254203 (1), 15509179 (1)
    doxorubicin 17.1 4 15189276 (1), 11489324 (1), 20403430 (1)
    lysine 6.87 2 7873664 (1), 7948096 (1)
    ethanol 5.89 5 18336663 (3), 14986823 (1), 18161881 (1)
    calcium 0 3 12477859 (1), 7844558 (1)
    fatty acid 0 1 8668674 (1)

    Search CenterWatch for drugs/clinical trials and news about ASGR2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ASGR2 gene (5 alternative transcripts): 
    NM_001181.4  NM_001201352.1  NM_080912.3  NM_080913.3  NM_080914.2  

    Unigene Cluster for ASGR2:

    Asialoglycoprotein receptor 2
    Hs.654440  [show with all ESTs]
    Unigene Representative Sequence: NM_080912
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355035(uc002gen.1) ENST00000254850(uc002geq.3) ENST00000446679
    ENST00000576487(uc010clw.2) ENST00000450034(uc010vtl.1) ENST00000574868
    ENST00000380952(uc002gep.3 uc002geo.2 uc002ger.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    hsa-miR-3685 hsa-miR-4264
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    Additional mRNA sequence: 

    AF529374.1 AK310123.1 BC017251.2 M11025.1 U97197.1 X55283.1 X55284.1 

    4 DOTS entries:

    DT.91677142  DT.92324210  DT.100755545  DT.95259760 

    24/65 AceView cDNA sequences (see all 65):

    BQ651695 AF529374 AI635553 BC017251 NM_080913 BQ648893 CR594935 BQ647289 
    NM_080914 BX283340 AI953147 AL532507 NM_080912 X55283 X55284 BQ653411 
    AW950089 BQ648417 BV194484 BX483468 U97197 BQ653259 CB111973 BU506758 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ASGR2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
    SP1:                          -           -                                             
    SP2:                                      -                                             
    SP3:                                                                                    
    SP4:                          -                                                         
    SP5:                                                                                    


    ECgene alternative splicing isoforms for ASGR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ASGR2 expression in normal human tissues (normalized intensities)      ASGR2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCTGCTTCA
    ASGR2 Expression
    About this image


    ASGR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Blood (Extraembryonic Tissues)    fully expand to see all 4 entries
             Fetal Liver CD36+ Cells   
             cd14+ cells   
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Human Hepatocyte (HH)   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Cord Blood CD133- Cells   
     
     Ovary (Reproductive System)
             oocyte   
     
     Gut Tube (Gastrointestinal Tract)
             Endoderm progenitor-like cells ( Generation and expansion of endodermal progenitor...

    See ASGR2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ASGR2

    SOURCE GeneReport for Unigene cluster: Hs.654440

    UniProtKB/Swiss-Prot: ASGR2_HUMAN, P07307
    Tissue specificity: Expressed exclusively in hepatic parenchymal cells

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASGR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ASGR2 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Asgr21 , 5 asialoglycoprotein receptor 21, 5 75.44(n)1
    66(a)1
      11 (42.99 cM)5
    118901  NM_007493.31  NP_031519.11 
     700926445 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    34(a)
    possible ortholog
    2(80104375-80116126)
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-283g2.26
    si:ch211-283g2.36
    (see all 4)
    si:ch211-283g2.3
    (see all 4)
    29(a)
    25(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    5(4216874-4227037)
    5(4242809-4252482)


    ENSEMBL Gene Tree for ASGR2 (if available)
    TreeFam Gene Tree for ASGR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ASGR2 gene
    CD2072  CLEC17A2  CLEC4E2  CLEC4M2  CLEC4F2  CD2092  CLEC4A2  FCER22  
    CLEC10A2  CLEC6A2  ASGR12  CLEC4C2  CLEC4D2  CLEC4G2  
    10 SIMAP similar genes for ASGR2 using alignment to 2 protein entries:     ASGR2_HUMAN (see all proteins):
    HBXBP    ASGR1    FCER2    CLEC10A    CLEC6A    CLEC4E
    REG1A    CLEC4D    CD209    REG4

    ASGR2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/529 SNPs in ASGR2 are shown (see all 529)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs670386011,2
    C,F--6902496(+) TAGCA-/T/TT  
            
    TTTTT
    5 -- int12NA CSA 4
    rs1422667961,2
    C--6910184(+) ACAAC-/ATACACA 5 -- int10--------
    rs1128590961,2
    C,F--6992184(+) AGTGCC/TGCCAA 5 -- ds50012Minor allele frequency- T:0.50WA CSA 4
    rs1450065781,2
    --6992185(+) GTGCCA/GCCAAA 5 -- ds50010--------
    rs1409699221,2
    C--6992251(+) AGCACG/TCTGTC 5 -- ds50010--------
    rs1446946951,2
    --6992259(+) GTCACC/GTCTCA 5 -- ds50010--------
    rs665517661,2
    C,F--6992335(+) AAGCCT/CGTCTG 5 -- ds50016Minor allele frequency- C:0.30NA WA CSA EA 363
    rs732421821,2
    C,F--6992352(+) GCCCCT/CTTCCC 5 -- ds50015Minor allele frequency- C:0.25WA CSA 126
    rs1147720891,2
    C,F--6992371(+) GACCAA/GTGTCC 5 -- ds50011Minor allele frequency- G:0.03WA 118
    rs668573411,2
    C,F--6992432(+) TTCCAT/CGCCCT 5 -- ds50019Minor allele frequency- C:0.30WA NA CSA EA 370

    HapMap Linkage Disequilibrium report for ASGR2 (7004641 - 7019019 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ASGR2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2665200CNV Deletion23128226
    esv2422288CNV Deletion17116639
    nsv907635CNV Loss21882294
    nsv457659CNV Loss19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 108361    OMIM disorders: --

    13 diseases for ASGR2:    About MalaCards
    hepatitis b    hepatitis    autoimmune hepatitis    alcoholic liver cirrhosis
    liver cirrhosis    urethritis    hepatitis c    liver disease
    jaundice    hepatocellular carcinoma    alcoholism    influenza
    leukemia

    2 diseases from the University of Copenhagen DISEASES database for ASGR2:
    Autoimmune hepatitis     Hepatitis

    ASGR2 for disorders           About GeneDecksing

    10/21 Novoseek inferred disease relationships for ASGR2 gene (see all 21)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatitis autoimmune 61.6 6 19576873 (2), 8590155 (1), 15890353 (1), 7508490 (1) (see all 5)
    hepatitis chronic active 57 3 1979365 (1), 1532926 (1), 12002624 (1)
    hepatitis chronic 53.8 2 7508490 (1), 1955777 (1)
    other liver diseases 51.8 1 16396634 (1)
    liver diseases 42 5 1532926 (2), 15890353 (1), 1955777 (1), 8301043 (1)
    hepatocellular carcinoma 41.9 7 10075085 (2), 16396634 (1), 10507763 (1), 20403430 (1) (see all 6)
    liver damage 41.8 1 16920400 (1)
    liver mass 40 1 9935069 (1)
    autoimmune response 34.6 1 1955777 (1)
    liver cirrhosis 29.5 1 12297928 (1)

    Human Genome Epidemiology (HuGE) Navigator: ASGR2 (1 document)

    Export disorders for ASGR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ASGR2 gene, integrated from 9 sources (see all 147):
    (articles sorted by number of sources associating them with ASGR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence of a second human asialoglycoprotein receptor: conservation of two receptor genes during evolution. (PubMed id 3863106)1, 2, 3 Spiess M. and Lodish H.F. (1985)
    2. The B domain of coagulation factor VIII interacts with the asialoglycoprotein receptor. (PubMed id 15946216)1, 7 Bovenschen N....Mertens K. (2005)
    3. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1. (PubMed id 11543633)1, 2 Pan H....Gu J.-R. (2001)
    6. Differences in the abundance of variably spliced transcripts for the second asialoglycoprotein receptor polypeptide, H2, in normal and transformed human liver. (PubMed id 1371982)1, 2 Paietta E.... Racevskis J. (1992)
    7. Targeted delivery of macromolecular drugs: asialoglycoprotein receptor (ASGPR) expression by selected hepatoma cell lines used in antiviral drug development. (PubMed id 18855599)1, 9 Li Y....Wiebe L.I. (2008)
    8. Role of the asialoglycoprotein receptor in binding and entry of hepatitis C virus structural proteins in cultured human hepatocytes. (PubMed id 12477859)1, 9 Saunier B....Kohn L.D. (2003)
    9. Autoantibodies to asialoglycoprotein receptor (ASGPR) measured by a novel ELISA--revival of a disease-activity marker in autoimmune hepatitis. (PubMed id 19576873)1, 9 Hausdorf G....Klein R. (2009)
    10. H2, the minor subunit of the human asialoglycoprotein receptor, trafficks intracellularly and forms homo-oligomers, but does not bind asialo-orosomucoid. (PubMed id 12089159)1, 9 Saxena A....Weigel P.H. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 433 HGNC: 743 AceView: ASGR2 Ensembl:ENSG00000161944 euGenes: HUgn433
    ECgene: ASGR2 Kegg: 433 H-InvDB: ASGR2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ASGR2 Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_216

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ASGR2 gene:
    Search GeneIP for patents involving ASGR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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