Aliases for ASGR2 Gene
Aliases for ASGR2 Gene
External Ids for ASGR2 Gene
- HGNC: 743
- Entrez Gene: 433
- Ensembl: ENSG00000161944
- OMIM: 108361
- UniProtKB: P07307
Previous GeneCards Identifiers for ASGR2 Gene
- GC17M007393
- GC17M007735
- GC17M006949
- GC17M007205
- GC17M006945
- GC17M007004
- GC17M006898
Summaries for ASGR2 Gene
-
This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
GeneCards Summary for ASGR2 Gene
ASGR2 (Asialoglycoprotein Receptor 2) is a Protein Coding gene. Diseases associated with ASGR2 include Hepatitis B. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism of proteins. GO annotations related to this gene include carbohydrate binding and asialoglycoprotein receptor activity. An important paralog of this gene is ASGR1.
UniProtKB/Swiss-Prot for ASGR2 Gene
-
Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASGR2 Gene
Genomics for ASGR2 Gene
Regulatory Elements for ASGR2 Gene
- Transcription factor binding sites by QIAGEN in the ASGR2 gene promoter:
Regulatory Element Products
Genomic Location for ASGR2 Gene
- Chromosome:
- 17
- Start:
- 7,101,322 bp from pter
- End:
- 7,115,700 bp from pter
- Size:
- 14,379 bases
- Orientation:
- Minus strand
Genomic View for ASGR2 Gene
- Cytogenetic band:
-
- 17p13.1 by Ensembl
- 17p13.1 by Entrez Gene
- 17p13.1 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ASGR2 Gene
Proteins for ASGR2 Gene
-
Protein details for ASGR2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P07307-ASGR2_HUMAN
- Recommended name:
- Asialoglycoprotein receptor 2
- Protein Accession:
- P07307
- A6NLV8
- A8MT12
- D3DTM9
- D3DTN0
- O00448
- Q03969
Protein attributes for ASGR2 Gene
- Size:
- 311 amino acids
- Molecular mass:
- 35092 Da
- Quaternary structure:
-
- The functioning ligand-binding unit of this receptor is thought to be at least a dimer. Interacts with LASS2.
- Miscellaneous:
-
- Calcium is required for ligand binding.
Protein Expression for ASGR2 Gene
Post-translational modifications for ASGR2 Gene
Other Protein References for ASGR2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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-
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Protein Products
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-
Cloud-Clone Corp. Proteins for ASGR2
- antibodies-online Proteins for ASGR2: See all 11
- Search antibodies-online for peptides
- Search GeneTex for Proteins for ASGR2
No data available for DME Specific Peptides for ASGR2 Gene
Domains & Families for ASGR2 Gene
Gene Families for ASGR2 Gene
Protein Domains for ASGR2 Gene
Suggested Antigen Peptide Sequences for ASGR2 Gene
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for ASGR2 Gene
Function for ASGR2 Gene
Molecular function for ASGR2 Gene
- UniProtKB/Swiss-Prot Function:
- Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004873 | asialoglycoprotein receptor activity | TAS | 3863106 |
| GO:0005515 | protein binding | IPI | 11543633 |
| GO:0030246 | carbohydrate binding | IEA | -- |
Phenotypes for ASGR2 Gene
- MGI mutant phenotypes for ASGR2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ASGR2:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability in esophageal squamous lineage
- Decreased NF-kappaB reporter expression
- Increased transferrin (TF) endocytosis
- Decreased number of cells in monopolar arrest with EMD534085 (a Kinesin-5 inhibitor)
- Increased HPV16-GFP infection
- Decreased Salmonella proliferation
Animal Models for ASGR2 Gene
- MGI Knock Outs for ASGR2:
-
- Asgr2 tm1Her
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for ASGR2 gene
-
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CRISPR Products
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miRNA for ASGR2 Gene
- miRTarBase miRNAs that target ASGR2
-
- hsa-mir-2467-3p (MIRT488736)
- hsa-mir-3197 (MIRT488737)
- hsa-mir-4673 (MIRT488738)
- hsa-mir-6847-5p (MIRT488739)
- hsa-mir-4645-5p (MIRT488740)
- hsa-mir-6511a-5p (MIRT488741)
- hsa-mir-1910-3p (MIRT488742)
- hsa-mir-4695-5p (MIRT488743)
- hsa-mir-527 (MIRT504321)
- hsa-mir-518a-5p (MIRT504322)
- hsa-mir-548aw (MIRT504323)
- hsa-mir-137 (MIRT504324)
- hsa-mir-4468 (MIRT504325)
- hsa-mir-92b-3p (MIRT504326)
- hsa-mir-92a-3p (MIRT504327)
- hsa-mir-367-3p (MIRT504328)
- hsa-mir-363-3p (MIRT504329)
- hsa-mir-32-5p (MIRT504330)
- hsa-mir-25-3p (MIRT504331)
- hsa-mir-6838-5p (MIRT504332)
- hsa-mir-497-5p (MIRT504333)
- hsa-mir-424-5p (MIRT504334)
- hsa-mir-195-5p (MIRT504335)
- hsa-mir-16-5p (MIRT504336)
- hsa-mir-15b-5p (MIRT504337)
- hsa-mir-15a-5p (MIRT504338)
- hsa-mir-451b (MIRT504339)
- hsa-mir-5586-3p (MIRT504340)
- hsa-mir-3133 (MIRT504341)
- hsa-mir-1276 (MIRT504342)
- hsa-mir-4514 (MIRT569489)
- hsa-mir-4692 (MIRT569490)
- hsa-mir-632 (MIRT646682)
- hsa-mir-4288 (MIRT646683)
- hsa-mir-6828-3p (MIRT646684)
- hsa-mir-346 (MIRT646685)
- hsa-mir-3120-5p (MIRT646686)
- hsa-mir-767-3p (MIRT646687)
- hsa-mir-5695 (MIRT646688)
- hsa-mir-6769a-3p (MIRT646689)
miRNA Products
- Search ViGene Biosciences for ASGR2
Inhibitory RNA Products
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Clone Products
-
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- VectorBuilder custom plasmid, inducible vectors for ASGR2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ASGR2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for ASGR2
Cell Line Products
-
Horizon Cell Lines for ASGR2
-
ViGene Biosciences adenoviral particle packaged cDNA for ASGR2 gene
-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ASGR2 Gene
Localization for ASGR2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ASGR2 Gene
- Membrane; Single-pass type II membrane protein.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for ASGR2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Metabolism of proteins | ||
| 2 | Insulin secretion | ||
| 3 | Transport to the Golgi and subsequent modification | ||
Pathways by source for ASGR2 Gene
3 Reactome pathways for ASGR2 Gene
1 KEGG pathway for ASGR2 Gene
Interacting Proteins for ASGR2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006897 | endocytosis | IEA | -- |
| GO:0006898 | receptor-mediated endocytosis | IEA | -- |
| GO:0007166 | cell surface receptor signaling pathway | TAS | 3863106 |
| GO:0009100 | glycoprotein metabolic process | IEA | -- |
| GO:0018279 | protein N-linked glycosylation via asparagine | TAS | -- |
No data available for SIGNOR curated interactions for ASGR2 Gene
Transcripts for ASGR2 Gene
mRNA/cDNA for ASGR2 Gene
- (16) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (65) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ASGR2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ASGR2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ASGR2
- GenScript: Design CRISPR guide RNA sequences for ASGR2
miRNA Products
- Search ViGene Biosciences for ASGR2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ASGR2
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-
ViGene Biosciences ready-to-package AAV shRNAs for ASGR2 gene
Clone Products
-
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ASGR2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ASGR2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for ASGR2
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||
| SP5: |
Expression for ASGR2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for ASGR2 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ASGR2 Gene
NURSA nuclear receptor signaling pathways regulating expression of ASGR2 Gene:
ASGR2SOURCE GeneReport for Unigene cluster for ASGR2 Gene:
Hs.654440mRNA Expression by UniProt/SwissProt for ASGR2 Gene:
P07307-ASGR2_HUMANEvidence on tissue expression from TISSUES for ASGR2 Gene
- Liver(4.7)
- Bone marrow(4.1)
Primer Products
-
OriGene qPCR primer pairs for ASGR2
-
OriGene qPCR primer pairs and template standards for ASGR2
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ASGR2 Gene
Orthologs for ASGR2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ASGR2 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | ASGR2 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | ASGR2 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Asgr2 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Asgr2 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | si:ch211-283g2.2 35 |
|
ManyToMany | |
| si:ch73-361h17.1 35 |
|
ManyToMany | |||
| si:ch211-283g2.3 35 |
|
ManyToMany |
- Species where no ortholog for ASGR2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ASGR2 Gene
Paralogs for ASGR2 Gene
(10) SIMAP similar genes for ASGR2 Gene using alignment to 2 proteins:
Variants for ASGR2 Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000103337 | -- | 7,102,804(+) | GACCC(A/G)CTGCC | intron-variant | |
| rs1000274189 | -- | 7,115,675(+) | CCAAC(A/C)TGGTG | upstream-variant-2KB | |
| rs1000583701 | -- | 7,115,459(+) | GGTTC(C/G)GAAGC | upstream-variant-2KB, utr-variant-5-prime | |
| rs1000716696 | -- | 7,111,581(+) | AACCC(G/T)GGAGG | intron-variant | |
| rs1000889821 | -- | 7,106,805(+) | AGGCC(A/G)AGGCA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2422288 | CNV | deletion | 17116639 |
| esv2665200 | CNV | deletion | 23128226 |
| esv3639859 | CNV | loss | 21293372 |
| esv3639860 | CNV | gain | 21293372 |
| nsv1071366 | CNV | deletion | 25765185 |
| nsv1131297 | CNV | deletion | 24896259 |
| nsv1138495 | CNV | deletion | 24896259 |
| nsv457659 | CNV | loss | 19166990 |
| nsv574322 | CNV | loss | 21841781 |
Relevant External Links for ASGR2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ASGR2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASGR2 Gene
Disorders for ASGR2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hepatitis b |
|
Relevant External Links for ASGR2
No data available for UniProtKB/Swiss-Prot and Genatlas for ASGR2 Gene
Publications for ASGR2 Gene
- Sequence of a second human asialoglycoprotein receptor: conservation of two receptor genes during evolution. (PMID: 3863106) Spiess M. … Lodish H.F. (Proc. Natl. Acad. Sci. U.S.A. 1985) 2 3 4 64
- Autoantibodies to asialoglycoprotein receptor (ASGPR) measured by a novel ELISA--revival of a disease-activity marker in autoimmune hepatitis. (PMID: 19576873) Hausdorf G. … Klein R. (Clin. Chim. Acta 2009) 3 22 64
- An internalizing antibody specific for the human asialoglycoprotein receptor. (PMID: 19663694) Trahtenherts A. … Benhar I. (Hybridoma (Larchmt) 2009) 3 22 64
- Targeted delivery of macromolecular drugs: asialoglycoprotein receptor (ASGPR) expression by selected hepatoma cell lines used in antiviral drug development. (PMID: 18855599) Li Y. … Wiebe L.I. (Curr Drug Deliv 2008) 3 22 64
- Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T. … Smith R.D. (J. Proteome Res. 2005) 3 4 64
Products for ASGR2 Gene
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- antibodies-online Antibodies for ASGR2: See all 37
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- antibodies-online Proteins for ASGR2: See all 11
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- GeneTex ASGR2 antibody for ASGR2
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- ViGene Biosciences adenoviral particle packaged cDNA for ASGR2 gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for ASGR2
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- Custom Antibody ServicesProSci Antibodies for ASGR2
- Search for ASGR2 Proteins at ProSci
- Horizon Cell Lines for ASGR2
- Cyagen custom Knockout/knockin (KOKI) mouse models for ASGR2
- VectorBuilder custom plasmid, inducible vectors for ASGR2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ASGR2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ASGR2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
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- (94) RefSeq
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- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
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- (104) Addgene
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- (106) CYP
- (107) NONCODE
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- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
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- (115) ProteomicsDB
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- (122) diseasecard
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- (140) FANTOM5
- (141) ENCODE
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- (143) Horizon
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- (150) St John's Lab
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- (154) TISSUES
- (155) Gene ORGANizer




