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Aliases for ASGR2 Gene

Aliases for ASGR2 Gene

  • Asialoglycoprotein Receptor 2 2 3 5
  • C-Type Lectin Domain Family 4 Member H2 3 4
  • Hepatic Lectin H2 3 4
  • CLEC4H2 3 4
  • HL-2 3 4
  • HBxAg-Binding Protein 3
  • ASGP-R 2 4
  • ASGP-R2 3
  • ASGPR 2 4
  • ASGPR2 3
  • HBXBP 3

External Ids for ASGR2 Gene

Previous GeneCards Identifiers for ASGR2 Gene

  • GC17M007393
  • GC17M007735
  • GC17M006949
  • GC17M007205
  • GC17M006945
  • GC17M007004
  • GC17M006898

Summaries for ASGR2 Gene

Entrez Gene Summary for ASGR2 Gene

  • This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for ASGR2 Gene

ASGR2 (Asialoglycoprotein Receptor 2) is a Protein Coding gene. Among its related pathways are Insulin secretion. GO annotations related to this gene include carbohydrate binding and asialoglycoprotein receptor activity. An important paralog of this gene is CLEC6A.

UniProtKB/Swiss-Prot for ASGR2 Gene

  • Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASGR2 Gene

Genomics for ASGR2 Gene

Regulatory Elements for ASGR2 Gene

Promoters for ASGR2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ASGR2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ASGR2 Gene

Chromosome:
17
Start:
7,101,322 bp from pter
End:
7,115,700 bp from pter
Size:
14,379 bases
Orientation:
Minus strand

Genomic View for ASGR2 Gene

Genes around ASGR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASGR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASGR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASGR2 Gene

Proteins for ASGR2 Gene

  • Protein details for ASGR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07307-ASGR2_HUMAN
    Recommended name:
    Asialoglycoprotein receptor 2
    Protein Accession:
    P07307
    Secondary Accessions:
    • A6NLV8
    • A8MT12
    • D3DTM9
    • D3DTN0
    • O00448
    • Q03969

    Protein attributes for ASGR2 Gene

    Size:
    311 amino acids
    Molecular mass:
    35092 Da
    Quaternary structure:
    • The functioning ligand-binding unit of this receptor is thought to be at least a dimer. Interacts with LASS2.
    Miscellaneous:
    • Calcium is required for ligand binding.

    Alternative splice isoforms for ASGR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASGR2 Gene

Proteomics data for ASGR2 Gene at MOPED

Post-translational modifications for ASGR2 Gene

  • Glycosylation at Asn 102, Asn 170, and Asn 305
  • Modification sites at PhosphoSitePlus

Other Protein References for ASGR2 Gene

Antibody Products

No data available for DME Specific Peptides for ASGR2 Gene

Domains & Families for ASGR2 Gene

Gene Families for ASGR2 Gene

Graphical View of Domain Structure for InterPro Entry

P07307

UniProtKB/Swiss-Prot:

ASGR2_HUMAN :
  • Contains 1 C-type lectin domain.
Domain:
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with ASGR2: view

Function for ASGR2 Gene

Molecular function for ASGR2 Gene

UniProtKB/Swiss-Prot Function:
Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

Gene Ontology (GO) - Molecular Function for ASGR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004873 asialoglycoprotein receptor activity TAS 3863106
genes like me logo Genes that share ontologies with ASGR2: view
genes like me logo Genes that share phenotypes with ASGR2: view

Animal Models for ASGR2 Gene

MGI Knock Outs for ASGR2:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ASGR2 Gene

Localization for ASGR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ASGR2 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ASGR2 Gene COMPARTMENTS Subcellular localization image for ASGR2 gene
Compartment Confidence
plasma membrane 3
extracellular 2
cytosol 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for ASGR2 Gene

Pathways & Interactions for ASGR2 Gene

SuperPathways for ASGR2 Gene

Superpath Contained pathways
1 Insulin secretion
genes like me logo Genes that share pathways with ASGR2: view

Pathways by source for ASGR2 Gene

1 KEGG pathway for ASGR2 Gene

Gene Ontology (GO) - Biological Process for ASGR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway TAS 3863106
GO:0009100 glycoprotein metabolic process IEA --
GO:0030282 bone mineralization IEA --
GO:0055088 lipid homeostasis IEA --
genes like me logo Genes that share ontologies with ASGR2: view

No data available for SIGNOR curated interactions for ASGR2 Gene

Drugs & Compounds for ASGR2 Gene

(5) Drugs for ASGR2 Gene - From: DrugBank, Novoseek, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Antihemophilic Factor Approved, Investigational Pharma Target, binder 0
calcium Nutra 0

(8) Additional Compounds for ASGR2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ASGR2: view

Transcripts for ASGR2 Gene

Unigene Clusters for ASGR2 Gene

Asialoglycoprotein receptor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ASGR2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - -
SP2: -
SP3:
SP4: -
SP5:

Relevant External Links for ASGR2 Gene

GeneLoc Exon Structure for
ASGR2
ECgene alternative splicing isoforms for
ASGR2

Expression for ASGR2 Gene

mRNA expression in normal human tissues for ASGR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ASGR2 Gene

This gene is overexpressed in Liver (x46.7).

Protein differential expression in normal tissues from HIPED for ASGR2 Gene

This gene is overexpressed in Serum (33.7), Plasma (14.8), and Fetal Liver (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ASGR2 Gene



SOURCE GeneReport for Unigene cluster for ASGR2 Gene Hs.654440

mRNA Expression by UniProt/SwissProt for ASGR2 Gene

P07307-ASGR2_HUMAN
Tissue specificity: Expressed exclusively in hepatic parenchymal cells.
genes like me logo Genes that share expression patterns with ASGR2: view

Protein tissue co-expression partners for ASGR2 Gene

In Situ Assay Products

Orthologs for ASGR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ASGR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ASGR2 35
  • 99.46 (n)
  • 98.71 (a)
ASGR2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ASGR2 36
  • 71 (a)
OneToOne
ASGR2 35
  • 80.16 (n)
  • 72.58 (a)
dog
(Canis familiaris)
Mammalia ASGR2 35
  • 77.41 (n)
  • 66.45 (a)
ASGR2 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Asgr2 16
Asgr2 36
  • 66 (a)
OneToOne
Asgr2 35
  • 75.44 (n)
  • 66 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 27 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Asgr2 35
  • 76.11 (n)
  • 63.67 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 40 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch211-283g2.2 36
  • 31 (a)
ManyToMany
si:ch211-283g2.3 36
  • 21 (a)
ManyToMany
si:ch73-361h17.1 36
  • 24 (a)
ManyToMany
Species with no ortholog for ASGR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ASGR2 Gene

ENSEMBL:
Gene Tree for ASGR2 (if available)
TreeFam:
Gene Tree for ASGR2 (if available)

Paralogs for ASGR2 Gene

(10) SIMAP similar genes for ASGR2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ASGR2: view

Variants for ASGR2 Gene

Sequence variations from dbSNP and Humsavar for ASGR2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs190087 -- 7,111,790(-) cgtgt(A/C/T)gacct intron-variant
rs167536 -- 7,112,045(-) tcccc(C/T)cTCTC intron-variant
rs434325 -- 7,108,030(+) GGACC(A/C)CACCC intron-variant
rs314234 -- 7,104,545(-) tctcc(C/T)gagta intron-variant
rs314235 -- 7,111,472(-) tcacc(A/G/T)tgtta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ASGR2 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv457659 CNV Loss 19166990
nsv907635 CNV Loss 21882294
esv2665200 CNV Deletion 23128226

Variation tolerance for ASGR2 Gene

Residual Variation Intolerance Score: 51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.83; 79.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ASGR2 Gene

HapMap Linkage Disequilibrium report
ASGR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASGR2 Gene

Disorders for ASGR2 Gene

Relevant External Links for ASGR2

Human Genome Epidemiology (HuGE) Navigator
ASGR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ASGR2

No disorders were found for ASGR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASGR2 Gene

Publications for ASGR2 Gene

  1. Sequence of a second human asialoglycoprotein receptor: conservation of two receptor genes during evolution. (PMID: 3863106) Spiess M. … Lodish H.F. (Proc. Natl. Acad. Sci. U.S.A. 1985) 2 3 4 67
  2. Autoantibodies to asialoglycoprotein receptor (ASGPR) measured by a novel ELISA--revival of a disease-activity marker in autoimmune hepatitis. (PMID: 19576873) Hausdorf G. … Klein R. (Clin. Chim. Acta 2009) 3 23
  3. An internalizing antibody specific for the human asialoglycoprotein receptor. (PMID: 19663694) Trahtenherts A. … Benhar I. (Hybridoma (Larchmt) 2009) 3 23
  4. Targeted delivery of macromolecular drugs: asialoglycoprotein receptor (ASGPR) expression by selected hepatoma cell lines used in antiviral drug development. (PMID: 18855599) Li Y. … Wiebe L.I. (Curr Drug Deliv 2008) 3 23
  5. The B domain of coagulation factor VIII interacts with the asialoglycoprotein receptor. (PMID: 15946216) Bovenschen N. … Mertens K. (J. Thromb. Haemost. 2005) 3 25

Products for ASGR2 Gene

Sources for ASGR2 Gene

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