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Aliases for ASGR2 Gene

Aliases for ASGR2 Gene

  • Asialoglycoprotein Receptor 2 2 3
  • C-Type Lectin Domain Family 4 Member H2 3 4
  • Hepatic Lectin H2 3 4
  • CLEC4H2 3 4
  • HL-2 3 4
  • HBxAg-Binding Protein 3
  • ASGP-R 2 4
  • ASGP-R2 3
  • ASGPR 2 4
  • ASGPR2 3
  • HBXBP 3

External Ids for ASGR2 Gene

Previous GeneCards Identifiers for ASGR2 Gene

  • GC17M007393
  • GC17M007735
  • GC17M006949
  • GC17M007205
  • GC17M006945
  • GC17M007004
  • GC17M006898

Summaries for ASGR2 Gene

Entrez Gene Summary for ASGR2 Gene

  • This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for ASGR2 Gene

ASGR2 (Asialoglycoprotein Receptor 2) is a Protein Coding gene. Diseases associated with ASGR2 include hepatitis b and liver cirrhosis. Among its related pathways are Insulin secretion. GO annotations related to this gene include carbohydrate binding and asialoglycoprotein receptor activity. An important paralog of this gene is CLEC4D.

UniProtKB/Swiss-Prot for ASGR2 Gene

  • Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASGR2 Gene

Genomics for ASGR2 Gene

Regulatory Elements for ASGR2 Gene

Genomic Location for ASGR2 Gene

Start:
7,101,322 bp from pter
End:
7,115,700 bp from pter
Size:
14,379 bases
Orientation:
Minus strand

Genomic View for ASGR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ASGR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASGR2 Gene

Proteins for ASGR2 Gene

  • Protein details for ASGR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07307-ASGR2_HUMAN
    Recommended name:
    Asialoglycoprotein receptor 2
    Protein Accession:
    P07307
    Secondary Accessions:
    • A6NLV8
    • A8MT12
    • D3DTM9
    • D3DTN0
    • O00448
    • Q03969

    Protein attributes for ASGR2 Gene

    Size:
    311 amino acids
    Molecular mass:
    35092 Da
    Quaternary structure:
    • The functioning ligand-binding unit of this receptor is thought to be at least a dimer. Interacts with LASS2.
    Miscellaneous:
    • Calcium is required for ligand binding

    Alternative splice isoforms for ASGR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASGR2 Gene

Proteomics data for ASGR2 Gene at MOPED

Post-translational modifications for ASGR2 Gene

  • Glycosylation at Asn102, Asn170, and Asn305
  • Modification sites at PhosphoSitePlus

Other Protein References for ASGR2 Gene

Antibody Products

No data available for DME Specific Peptides for ASGR2 Gene

Domains for ASGR2 Gene

Gene Families for ASGR2 Gene

HGNC:
  • CLEC :C-type lectin domain containing

Graphical View of Domain Structure for InterPro Entry

P07307

UniProtKB/Swiss-Prot:

ASGR2_HUMAN :
  • P07307
Domain:
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with ASGR2: view

Function for ASGR2 Gene

Molecular function for ASGR2 Gene

UniProtKB/Swiss-Prot Function: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface

Gene Ontology (GO) - Molecular Function for ASGR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004873 asialoglycoprotein receptor activity TAS 3863106
GO:0005515 protein binding IPI 11543633
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with ASGR2: view
genes like me logo Genes that share phenotypes with ASGR2: view

Animal Models for ASGR2 Gene

MGI Knock Outs for ASGR2:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ASGR2 Gene

Localization for ASGR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ASGR2 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ASGR2 Gene COMPARTMENTS Subcellular localization image for ASGR2 gene
Compartment Confidence
plasma membrane 3
cytosol 2
endosome 2
extracellular 2
golgi apparatus 1
lysosome 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ASGR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ASGR2: view

Pathways for ASGR2 Gene

SuperPathways for ASGR2 Gene

Superpath Contained pathways
1 Insulin secretion
genes like me logo Genes that share pathways with ASGR2: view

Pathways by source for ASGR2 Gene

1 KEGG pathway for ASGR2 Gene

Gene Ontology (GO) - Biological Process for ASGR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis TAS 3863106
GO:0007166 cell surface receptor signaling pathway TAS 3863106
GO:0009100 glycoprotein metabolic process IEA --
GO:0030282 bone mineralization IEA --
GO:0031647 regulation of protein stability IEA --
genes like me logo Genes that share ontologies with ASGR2: view

Compounds for ASGR2 Gene

(1) HMDB Compounds for ASGR2 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Drugbank Compounds for ASGR2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Antihemophilic Factor
  • AHF
target binder

(12) Novoseek inferred chemical compound relationships for ASGR2 Gene

Compound -log(P) Hits PubMed IDs
pvla 87.3 6
galactose 69.8 18
sialic acid 42.4 2
spec-t 36.9 1
glycolipid 23.5 2
genes like me logo Genes that share compounds with ASGR2: view

Transcripts for ASGR2 Gene

Unigene Clusters for ASGR2 Gene

Asialoglycoprotein receptor 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ASGR2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ASGR2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - -
SP2: -
SP3:
SP4: -
SP5:

Relevant External Links for ASGR2 Gene

GeneLoc Exon Structure for
ASGR2
ECgene alternative splicing isoforms for
ASGR2

Expression for ASGR2 Gene

mRNA expression in normal human tissues for ASGR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ASGR2 Gene

This gene is overexpressed in Liver (46.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ASGR2 Gene

SOURCE GeneReport for Unigene cluster for ASGR2 Gene Hs.654440

mRNA Expression by UniProt/SwissProt for ASGR2 Gene

P07307-ASGR2_HUMAN
Tissue specificity: Expressed exclusively in hepatic parenchymal cells
genes like me logo Genes that share expressions with ASGR2: view

In Situ Assay Products

Orthologs for ASGR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ASGR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ASGR2 35
  • 99.46 (n)
  • 98.71 (a)
ASGR2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ASGR2 35
  • 80.16 (n)
  • 72.58 (a)
ASGR2 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ASGR2 35
  • 77.41 (n)
  • 66.45 (a)
ASGR2 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Asgr2 35
  • 75.44 (n)
  • 66 (a)
Asgr2 16
Asgr2 36
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 27 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Asgr2 35
  • 76.11 (n)
  • 63.67 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 40 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch211-283g2.2 36
  • 31 (a)
ManyToMany
si:ch211-283g2.3 36
  • 21 (a)
ManyToMany
si:ch73-361h17.1 36
  • 24 (a)
ManyToMany
Species with no ortholog for ASGR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ASGR2 Gene

ENSEMBL:
Gene Tree for ASGR2 (if available)
TreeFam:
Gene Tree for ASGR2 (if available)

Paralogs for ASGR2 Gene

Selected SIMAP similar genes for ASGR2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ASGR2: view

Variants for ASGR2 Gene

Sequence variations from dbSNP and Humsavar for ASGR2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs167536 -- 7,112,045(-) tcccc(C/T)cTCTC intron-variant
rs190087 -- 7,111,790(-) cgtgt(A/C/T)gacct intron-variant
rs314233 -- 7,104,939(-) gagtg(C/T)aatgg intron-variant
rs314234 -- 7,104,545(-) tctcc(C/T)gagta intron-variant
rs314235 -- 7,111,472(-) tcacc(A/G/T)tgtta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ASGR2 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv457659 CNV Loss 19166990
nsv907635 CNV Loss 21882294
esv2665200 CNV Deletion 23128226

Relevant External Links for ASGR2 Gene

HapMap Linkage Disequilibrium report
ASGR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASGR2 Gene

Disorders for ASGR2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for ASGR2 Gene including...

Search for ASGR2 Gene in MalaCards »

(2) University of Copenhagen DISEASES for ASGR2 Gene

(21) Novoseek inferred disease relationships for ASGR2 Gene

Disease -log(P) Hits PubMed IDs
hepatitis autoimmune 61.6 6
hepatitis chronic active 57 3
hepatitis chronic 53.8 2
other liver diseases 51.8 1
liver diseases 42 5

Relevant External Links for ASGR2

Human Genome Epidemiology (HuGE) Navigator
ASGR2
genes like me logo Genes that share disorders with ASGR2: view

No data available for UniProtKB/Swiss-Prot for ASGR2 Gene

Publications for ASGR2 Gene

  1. Sequence of a second human asialoglycoprotein receptor: conservation of two receptor genes during evolution. (PMID: 3863106) Spiess M. … Lodish H.F. (Proc. Natl. Acad. Sci. U.S.A. 1985) 2 3 4
  2. Differences in the abundance of variably spliced transcripts for the second asialoglycoprotein receptor polypeptide, H2, in normal and transformed human liver. (PMID: 1371982) Paietta E. … Racevskis J. (Hepatology 1992) 3 4
  3. H2, the minor subunit of the human asialoglycoprotein receptor, trafficks intracellularly and forms homo-oligomers, but does not bind asialo-orosomucoid. (PMID: 12089159) Saxena A. … Weigel P.H. (J. Biol. Chem. 2002) 3 23
  4. Targeted delivery of macromolecular drugs: asialoglycoprotein receptor (ASGPR) expression by selected hepatoma cell lines used in antiviral drug development. (PMID: 18855599) Li Y. … Wiebe L.I. (Curr Drug Deliv 2008) 3 23
  5. An internalizing antibody specific for the human asialoglycoprotein receptor. (PMID: 19663694) Trahtenherts A. … Benhar I. (Hybridoma (Larchmt) 2009) 3 23

Products for ASGR2 Gene

Sources for ASGR2 Gene

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