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Aliases for ASGR2 Gene

Aliases for ASGR2 Gene

  • Asialoglycoprotein Receptor 2 2 3 5
  • C-Type Lectin Domain Family 4 Member H2 3 4
  • Hepatic Lectin H2 3 4
  • CLEC4H2 3 4
  • HL-2 3 4
  • HBxAg-Binding Protein 3
  • ASGP-R 2 4
  • ASGP-R2 3
  • ASGPR 2 4
  • ASGPR2 3
  • HBXBP 3

External Ids for ASGR2 Gene

Previous GeneCards Identifiers for ASGR2 Gene

  • GC17M007393
  • GC17M007735
  • GC17M006949
  • GC17M007205
  • GC17M006945
  • GC17M007004
  • GC17M006898

Summaries for ASGR2 Gene

Entrez Gene Summary for ASGR2 Gene

  • This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for ASGR2 Gene

ASGR2 (Asialoglycoprotein Receptor 2) is a Protein Coding gene. Diseases associated with ASGR2 include Hepatitis B. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism of proteins. GO annotations related to this gene include carbohydrate binding and asialoglycoprotein receptor activity. An important paralog of this gene is ASGR1.

UniProtKB/Swiss-Prot for ASGR2 Gene

  • Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASGR2 Gene

Genomics for ASGR2 Gene

Regulatory Elements for ASGR2 Gene

Enhancers for ASGR2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F007112 1.6 FANTOM5 Ensembl ENCODE 18 +1.5 1473 4.3 HDGF PKNOX1 MLX ARID4B GLI4 YBX1 DMAP1 ZNF48 YY1 ZNF121 ASGR2 LOC100996842 SLC16A11 RPL7AP64 CLEC10A ASGR1 XAF1 SLC13A5 CD68 GABARAP
GH17F006710 1.3 FANTOM5 ENCODE 21.9 +403.6 403551 3.1 ARID4B YBX1 ZNF48 YY1 SLC30A9 GLIS2 ZNF143 ZNF207 PAF1 SP5 SLC13A5 ASGR1 ASGR2 LOC100996842 SLC16A13 SLC16A11 GC17M006685
GH17F007135 1.2 Ensembl ENCODE 11.5 -21.9 -21945 4.3 ELF3 ARID4B RAD21 RARA YY1 ZNF121 GLIS2 SCRT2 ZNF143 ZNF207 SLC16A11 RPL7AP64 ASGR2 BCL6B MIR324 CLEC10A KCNAB3 LOC105371512
GH17F007141 0.8 ENCODE 16.3 -26.2 -26179 1.3 PKNOX1 ARID4B SIN3A ZNF2 RAD21 ZBTB40 ZNF366 ZNF143 THAP11 MIXL1 ASGR2 SLC16A11 ASGR1 DVL2 PHF23 GABARAP CLDN7 ENSG00000202251 GC17M007141 RPL7AP64
GH17F007109 1 Ensembl 7.9 +5.9 5899 0.8 HDGF ATF1 SIN3A YBX1 ZNF48 YY1 GLIS2 SP3 KAT8 ETV4 ENSG00000262067 LOC105371508 SPEM1 LOC105371517 ASGR2 PIR50426 GC17P007091 GC17P007092 GC17P007093 GC17P007094
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ASGR2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ASGR2 Gene

Chromosome:
17
Start:
7,101,322 bp from pter
End:
7,115,700 bp from pter
Size:
14,379 bases
Orientation:
Minus strand

Genomic View for ASGR2 Gene

Genes around ASGR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASGR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASGR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASGR2 Gene

Proteins for ASGR2 Gene

  • Protein details for ASGR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07307-ASGR2_HUMAN
    Recommended name:
    Asialoglycoprotein receptor 2
    Protein Accession:
    P07307
    Secondary Accessions:
    • A6NLV8
    • A8MT12
    • D3DTM9
    • D3DTN0
    • O00448
    • Q03969

    Protein attributes for ASGR2 Gene

    Size:
    311 amino acids
    Molecular mass:
    35092 Da
    Quaternary structure:
    • The functioning ligand-binding unit of this receptor is thought to be at least a dimer. Interacts with LASS2.
    Miscellaneous:
    • Calcium is required for ligand binding.

    Alternative splice isoforms for ASGR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASGR2 Gene

Post-translational modifications for ASGR2 Gene

  • Glycosylation at Asn 102, Asn 170, and Asn 305
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ASGR2 Gene

Domains & Families for ASGR2 Gene

Gene Families for ASGR2 Gene

Graphical View of Domain Structure for InterPro Entry

P07307

UniProtKB/Swiss-Prot:

ASGR2_HUMAN :
  • Contains 1 C-type lectin domain.
Domain:
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with ASGR2: view

Function for ASGR2 Gene

Molecular function for ASGR2 Gene

UniProtKB/Swiss-Prot Function:
Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

Gene Ontology (GO) - Molecular Function for ASGR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004873 asialoglycoprotein receptor activity TAS 3863106
GO:0005515 protein binding IPI 11543633
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with ASGR2: view
genes like me logo Genes that share phenotypes with ASGR2: view

Animal Models for ASGR2 Gene

MGI Knock Outs for ASGR2:

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ASGR2 Gene

Localization for ASGR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ASGR2 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ASGR2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for ASGR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ASGR2: view

Pathways & Interactions for ASGR2 Gene

genes like me logo Genes that share pathways with ASGR2: view

Pathways by source for ASGR2 Gene

Gene Ontology (GO) - Biological Process for ASGR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
GO:0006898 receptor-mediated endocytosis IEA --
GO:0007166 cell surface receptor signaling pathway TAS 3863106
GO:0009100 glycoprotein metabolic process IEA --
GO:0030282 bone mineralization IEA --
genes like me logo Genes that share ontologies with ASGR2: view

No data available for SIGNOR curated interactions for ASGR2 Gene

Drugs & Compounds for ASGR2 Gene

(5) Drugs for ASGR2 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Antihemophilic Factor (Recombinant) Approved, Investigational Pharma Target, binder 0
calcium Nutra 0

(8) Additional Compounds for ASGR2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ASGR2: view

Transcripts for ASGR2 Gene

Unigene Clusters for ASGR2 Gene

Asialoglycoprotein receptor 2:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ASGR2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - -
SP2: -
SP3:
SP4: -
SP5:

Relevant External Links for ASGR2 Gene

GeneLoc Exon Structure for
ASGR2
ECgene alternative splicing isoforms for
ASGR2

Expression for ASGR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ASGR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ASGR2 Gene

This gene is overexpressed in Liver (x46.7).

Protein differential expression in normal tissues from HIPED for ASGR2 Gene

This gene is overexpressed in Serum (33.7), Plasma (14.8), and Fetal Liver (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ASGR2 Gene



Protein tissue co-expression partners for ASGR2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ASGR2 Gene:

ASGR2

SOURCE GeneReport for Unigene cluster for ASGR2 Gene:

Hs.654440

mRNA Expression by UniProt/SwissProt for ASGR2 Gene:

P07307-ASGR2_HUMAN
Tissue specificity: Expressed exclusively in hepatic parenchymal cells.
genes like me logo Genes that share expression patterns with ASGR2: view

Orthologs for ASGR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ASGR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ASGR2 34 35
  • 99.46 (n)
cow
(Bos Taurus)
Mammalia ASGR2 34 35
  • 80.16 (n)
dog
(Canis familiaris)
Mammalia ASGR2 34 35
  • 77.41 (n)
rat
(Rattus norvegicus)
Mammalia Asgr2 34
  • 76.11 (n)
mouse
(Mus musculus)
Mammalia Asgr2 34 16 35
  • 75.44 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 27 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 40 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch211-283g2.2 35
  • 31 (a)
ManyToMany
si:ch73-361h17.1 35
  • 24 (a)
ManyToMany
si:ch211-283g2.3 35
  • 21 (a)
ManyToMany
Species where no ortholog for ASGR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ASGR2 Gene

ENSEMBL:
Gene Tree for ASGR2 (if available)
TreeFam:
Gene Tree for ASGR2 (if available)

Paralogs for ASGR2 Gene

(10) SIMAP similar genes for ASGR2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ASGR2: view

Variants for ASGR2 Gene

Sequence variations from dbSNP and Humsavar for ASGR2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10438727 -- 7,112,761(+) TTGGC(C/G)AGCCT intron-variant
rs10459915 -- 7,114,031(+) CACAG(A/G)GTGGG intron-variant
rs10459916 -- 7,114,101(+) CCGCA(A/G)AAACT intron-variant
rs111072790 -- 7,113,552(+) ATACA(C/T)ACACA intron-variant
rs111529302 -- 7,107,573(+) ATACC(A/G)CACAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ASGR2 Gene

Variant ID Type Subtype PubMed ID
nsv574322 CNV loss 21841781
nsv457659 CNV loss 19166990
nsv1138495 CNV deletion 24896259
nsv1131297 CNV deletion 24896259
nsv1071366 CNV deletion 25765185
esv3639860 CNV gain 21293372
esv3639859 CNV loss 21293372
esv2665200 CNV deletion 23128226
esv2422288 CNV deletion 17116639

Variation tolerance for ASGR2 Gene

Residual Variation Intolerance Score: 51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.83; 79.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ASGR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ASGR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASGR2 Gene

Disorders for ASGR2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ASGR2 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
hepatitis b
  • chronic hepatitis b
- elite association - COSMIC cancer census association via MalaCards
Search ASGR2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ASGR2

Human Genome Epidemiology (HuGE) Navigator
ASGR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ASGR2
genes like me logo Genes that share disorders with ASGR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ASGR2 Gene

Publications for ASGR2 Gene

  1. Sequence of a second human asialoglycoprotein receptor: conservation of two receptor genes during evolution. (PMID: 3863106) Spiess M. … Lodish H.F. (Proc. Natl. Acad. Sci. U.S.A. 1985) 2 3 4 64
  2. Autoantibodies to asialoglycoprotein receptor (ASGPR) measured by a novel ELISA--revival of a disease-activity marker in autoimmune hepatitis. (PMID: 19576873) Hausdorf G. … Klein R. (Clin. Chim. Acta 2009) 3 22 64
  3. An internalizing antibody specific for the human asialoglycoprotein receptor. (PMID: 19663694) Trahtenherts A. … Benhar I. (Hybridoma (Larchmt) 2009) 3 22 64
  4. Targeted delivery of macromolecular drugs: asialoglycoprotein receptor (ASGPR) expression by selected hepatoma cell lines used in antiviral drug development. (PMID: 18855599) Li Y. … Wiebe L.I. (Curr Drug Deliv 2008) 3 22 64
  5. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T. … Smith R.D. (J. Proteome Res. 2005) 3 4 64

Products for ASGR2 Gene

Sources for ASGR2 Gene

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