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ASGR2 Gene

protein-coding   GIFtS: 62
GCID: GC17M007004

Asialoglycoprotein Receptor 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Asialoglycoprotein Receptor 21 2     ASGPR22
Hepatic Lectin H22 3     HBXBP2
CLEC4H22 3     HBxAg-Binding Protein2
HL-22 3     ASGP-R 23
C-Type Lectin Domain Family 4 Member H22 3     ASGPR 23
ASGP-R22     

External Ids:    HGNC: 7431   Entrez Gene: 4332   Ensembl: ENSG000001619447   OMIM: 1083615   UniProtKB: P073073   

Export aliases for ASGR2 gene to outside databases

Previous GC identifers: GC17M007393 GC17M007735 GC17M006949 GC17M007205 GC17M006945 GC17M006898


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ASGR2 Gene:
This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that
plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of
glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor
may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for
liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major
and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant
minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this
gene. (provided by RefSeq, Jan 2011)

GeneCards Summary for ASGR2 Gene:
ASGR2 (asialoglycoprotein receptor 2) is a protein-coding gene. Diseases associated with ASGR2 include hepatitis b, and hepatitis. GO annotations related to this gene include carbohydrate binding and asialoglycoprotein receptor activity. An important paralog of this gene is CD207.

UniProtKB/Swiss-Prot: ASGR2_HUMAN, P07307
Function: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their
complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and
N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and
transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the
cell membrane surface




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ASGR2 gene promoter:
         COUP-TF1   COUP-TF   COUP   Nkx2-5   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidASGR2 promoter sequence
   Search Chromatin IP Primers for ASGR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ASGR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p

ASGR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASGR2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M007004:  view genomic region     (about GC identifiers)

Start:
7,004,641 bp from pter      End:
7,019,019 bp from pter
Size:
14,379 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ASGR2_HUMAN, P07307 (See protein sequence)
Recommended Name: Asialoglycoprotein receptor 2  
Size: 311 amino acids; 35092 Da
Subunit: The functioning ligand-binding unit of this receptor is thought to be at least a dimer. Interacts with
LASS2
Miscellaneous: Calcium is required for ligand binding
Secondary accessions: A6NLV8 A8MT12 D3DTM9 D3DTN0 O00448 Q03969
Alternative splicing: 3 isoforms:  P07307-1   P07307-2   P07307-3   

Explore the universe of human proteins at neXtProt for ASGR2: NX_P07307

Explore proteomics data for ASGR2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn102, Asn170, Asn305
  • Modification sites at PhosphoSitePlus

  • See ASGR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001172.1  NP_001188281.1  NP_550434.1  NP_550435.1  NP_550436.1  

    ENSEMBL proteins: 
     ENSP00000347140   ENSP00000254850   ENSP00000405844   ENSP00000458835   ENSP00000370339  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CLEC: C-type lectin domain containing

    5 InterPro protein domains:
     IPR005640 Lectin_N
     IPR016187 C-type_lectin_fold
     IPR018378 C-type_lectin_CS
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry P07307

    ProtoNet protein and cluster: P07307

    2 Blocks protein domains:
    IPB002353 Type II antifreeze protein signature
    IPB005640 Hepatic lectin


    UniProtKB/Swiss-Prot: ASGR2_HUMAN, P07307
    Similarity: Contains 1 C-type lectin domain


    ASGR2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ASGR2_HUMAN, P07307
    Function: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their
    complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and
    N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and
    transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the
    cell membrane surface

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004873asialoglycoprotein receptor activity TAS3863106
    GO:0005515protein binding IPI11543633
    GO:0030246carbohydrate binding IEA--
         
    ASGR2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ASGR2:
     Decreased number of cells in m 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Asgr2):
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 

    ASGR2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Asgr2tm1Her for ASGR2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ASGR2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ASGR2
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    miRNA
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    hsa-miR-3685 hsa-miR-4264
    SwitchGear 3'UTR luciferase reporter plasmidASGR2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 5): ASGR2 (NM_001181)
    Sino Biological Human cDNA Clone for ASGR2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASGR2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ASGR2_HUMAN, P07307: Membrane; Single-pass type II membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytosol2
    endosome2
    extracellular2
    golgi apparatus1
    lysosome1
    nucleus1
    vacuole1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    ASGR2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ASGR2 About    
    See pathways by source

    SuperPathContained pathways About
    1Insulin secretion
    Thyroid hormone synthesis0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for ASGR2):
        Thyroid hormone synthesis


    ASGR2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ASGR2
    Interactions:

        Search GeneGlobe Interaction Network for ASGR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for ASGR2 (P073071, 3 ENSP000003471404) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CERS2Q96G231, 3, ENSP000002716884EBI-1172636,EBI-1057080 I2D: score=3 STRING: ENSP00000271688
    ASGR1P073063, ENSP000002692994I2D: score=1 STRING: ENSP00000269299
    F8P004513, ENSP000003533934I2D: score=1 STRING: ENSP00000353393
    EDEM1ENSP000002564974STRING: ENSP00000256497
    ERLEC1ENSP000001851504STRING: ENSP00000185150
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006898receptor-mediated endocytosis TAS3863106
    GO:0007166cell surface receptor signaling pathway TAS3863106
    GO:0009100glycoprotein metabolic process IEA--
    GO:0030282bone mineralization IEA--
    GO:0031647regulation of protein stability IEA--

    ASGR2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ASGR2

    1 HMDB Compound for ASGR2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for ASGR2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Antihemophilic FactorAHF (see all 3)--targetbinder17139284 15946216 17016423

    Selected Novoseek inferred chemical compound relationships for ASGR2 gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pvla 87.3 9 11444822 (3), 14586135 (1), 16004427 (1), 16158256 (1)
    galactose 69.8 21 18855599 (2), 9555658 (2), 15885467 (2), 17931643 (1) (see all 15)
    sialic acid 42.4 2 17103087 (1), 9989767 (1)
    spec-t 36.9 1 14575385 (1)
    glycolipid 23.5 2 16254203 (1), 15509179 (1)
    doxorubicin 17.1 4 15189276 (1), 11489324 (1), 20403430 (1)
    lysine 6.87 2 7873664 (1), 7948096 (1)
    ethanol 5.89 5 18336663 (3), 14986823 (1), 18161881 (1)
    calcium 0 3 12477859 (1), 7844558 (1)
    fatty acid 0 1 8668674 (1)



    ASGR2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ASGR2 gene (5 alternative transcripts): 
    NM_001181.4  NM_001201352.1  NM_080912.3  NM_080913.3  NM_080914.2  

    Unigene Cluster for ASGR2:

    Asialoglycoprotein receptor 2
    Hs.654440  [show with all ESTs]
    Unigene Representative Sequence: NM_080912
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355035(uc002gen.1) ENST00000254850(uc002geq.3) ENST00000446679
    ENST00000576487(uc010clw.2) ENST00000450034(uc010vtl.1) ENST00000574868
    ENST00000380952(uc002gep.3 uc002geo.2 uc002ger.3)
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate ASGR2:
    hsa-miR-3685 hsa-miR-4264
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    Additional mRNA sequence: 

    AF529374.1 AK310123.1 BC017251.2 M11025.1 U97197.1 X55283.1 X55284.1 

    4 DOTS entries:

    DT.91677142  DT.92324210  DT.100755545  DT.95259760 

    Selected AceView cDNA sequences (see all 65):

    AI635553 CR594935 AF529374 NM_080913 BQ647289 BQ651695 BQ648893 BC017251 
    CB161601 BE552264 NM_080912 BQ653259 BU506758 BV197615 BI253022 BV194484 
    M11025 BX483468 BM561839 CB111973 AL564408 NM_001181 NM_080914 BQ653411 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ASGR2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
    SP1:                          -           -                                             
    SP2:                                      -                                             
    SP3:                                                                                    
    SP4:                          -                                                         
    SP5:                                                                                    


    ECgene alternative splicing isoforms for ASGR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ASGR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCTGCTTCA
    ASGR2 Expression
    About this image


    ASGR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     NULL (Uncategorized)
             Endoderm progenitor-like cells
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
    ASGR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ASGR2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654440

    UniProtKB/Swiss-Prot: ASGR2_HUMAN, P07307
    Tissue specificity: Expressed exclusively in hepatic parenchymal cells

        Custom PCR Arrays for ASGR2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASGR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ASGR2 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Asgr21 , 5 asialoglycoprotein receptor 21, 5 75.44(n)1
    66(a)1
      11 (42.99 cM)5
    118901  NM_007493.31  NP_031519.11 
     700926445 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    40(a)
    1 → many
    AAWZ02038207(3409-9140)
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-283g2.26
    si:ch73-361h17.16
    (see all 3)
    si:ch73-361h17.1
    (see all 3)
    31(a)
    24(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    5(4216874-4227037) ENSDARG00000069025
    23(45443907-45457012) ENSDARG00000095963


    ENSEMBL Gene Tree for ASGR2 (if available)
    TreeFam Gene Tree for ASGR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ASGR2 gene
    CD2072  CLEC17A2  CLEC4E2  CLEC4M2  CLEC4F2  CD2092  CLEC4A2  FCER22  
    CLEC10A2  CLEC6A2  ASGR12  CLEC4C2  CLEC4D2  CLEC4G2  
    10 SIMAP similar genes for ASGR2 using alignment to 2 protein entries:     ASGR2_HUMAN (see all proteins):
    HBXBP    ASGR1    FCER2    CLEC10A    CLEC6A    CLEC4E
    REG1A    CLEC4D    CD209    REG4

    ASGR2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ASGR2 (see all 529)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs670386011,2
    C,F--6902496(+) TAGCA-/T/TT  
            
    TTTTT
    5 -- int12NA CSA 4
    rs1422667961,2
    C--6910184(+) ACAAC-/ATACACA 5 -- int10--------
    rs1128590961,2
    C,F--6992184(+) AGTGCC/TGCCAA 5 -- ds50012Minor allele frequency- T:0.50WA CSA 4
    rs1450065781,2
    --6992185(+) GTGCCA/GCCAAA 5 -- ds50010--------
    rs1409699221,2
    C--6992251(+) AGCACG/TCTGTC 5 -- ds50010--------
    rs1446946951,2
    --6992259(+) GTCACC/GTCTCA 5 -- ds50010--------
    rs665517661,2
    C,F--6992335(+) AAGCCT/CGTCTG 5 -- ds50016Minor allele frequency- C:0.30NA WA CSA EA 363
    rs732421821,2
    C,F--6992352(+) GCCCCT/CTTCCC 5 -- ds50015Minor allele frequency- C:0.25WA CSA 126
    rs1147720891,2
    C,F--6992371(+) GACCAA/GTGTCC 5 -- ds50011Minor allele frequency- G:0.03WA 118
    rs668573411,2
    C,F--6992432(+) TTCCAT/CGCCCT 5 -- ds50019Minor allele frequency- C:0.30WA NA CSA EA 370

    HapMap Linkage Disequilibrium report for ASGR2 (7004641 - 7019019 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ASGR2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665200CNV Deletion23128226
    esv2422288CNV Deletion17116639
    nsv907635CNV Loss21882294
    nsv457659CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 108361    OMIM disorders: --

    13 diseases for ASGR2:    
    About MalaCards
    hepatitis b    hepatitis    autoimmune hepatitis    alcoholic liver cirrhosis
    liver cirrhosis    urethritis    hepatitis c    liver disease
    hepatitis c virus    hepatocellular carcinoma    influenza    leukemia
    thyroiditis

    2 diseases from the University of Copenhagen DISEASES database for ASGR2:
    Autoimmune hepatitis     Hepatitis

    ASGR2 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for ASGR2 gene (see all 21)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatitis autoimmune 61.6 6 19576873 (2), 8590155 (1), 15890353 (1), 7508490 (1) (see all 5)
    hepatitis chronic active 57 3 1979365 (1), 1532926 (1), 12002624 (1)
    hepatitis chronic 53.8 2 7508490 (1), 1955777 (1)
    other liver diseases 51.8 1 16396634 (1)
    liver diseases 42 5 1532926 (2), 15890353 (1), 1955777 (1), 8301043 (1)
    hepatocellular carcinoma 41.9 7 10075085 (2), 16396634 (1), 10507763 (1), 20403430 (1) (see all 6)
    liver damage 41.8 1 16920400 (1)
    liver mass 40 1 9935069 (1)
    autoimmune response 34.6 1 1955777 (1)
    liver cirrhosis 29.5 1 12297928 (1)

    Human Genome Epidemiology (HuGE) Navigator: ASGR2 (1 document)

    Export disorders for ASGR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ASGR2 gene, integrated from 10 sources (see all 148):
    (articles sorted by number of sources associating them with ASGR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence of a second human asialoglycoprotein receptor: conservation of two receptor genes during evolution. (PubMed id 3863106)1, 2, 3 Spiess M. and Lodish H.F. (Proc. Natl. Acad. Sci. U.S.A. 1985)
    2. The B domain of coagulation factor VIII interacts with the asialoglycoprotein receptor. (PubMed id 15946216)1, 7 Bovenschen N....Mertens K. (J. Thromb. Haemost. 2005)
    3. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1. (PubMed id 11543633)1, 2 Pan H....Gu J.-R. (Genomics 2001)
    6. Differences in the abundance of variably spliced transcripts for the second asialoglycoprotein receptor polypeptide, H2, in normal and transformed human liver. (PubMed id 1371982)1, 2 Paietta E.... Racevskis J. (Hepatology 1992)
    7. Targeted delivery of macromolecular drugs: asialoglycoprotein receptor (ASGPR) expression by selected hepatoma cell lines used in antiviral drug development. (PubMed id 18855599)1, 9 Li Y....Wiebe L.I. (Curr Drug Deliv 2008)
    8. Role of the asialoglycoprotein receptor in binding and entry of hepatitis C virus structural proteins in cultured human hepatocytes. (PubMed id 12477859)1, 9 Saunier B....Kohn L.D. (J. Virol. 2003)
    9. Autoantibodies to asialoglycoprotein receptor (ASGPR) measured by a novel ELISA--revival of a disease-activity marker in autoimmune hepatitis. (PubMed id 19576873)1, 9 Hausdorf G....Klein R. ( international journal of clinical chemistry 2009)
    10. H2, the minor subunit of the human asialoglycoprotein receptor, trafficks intracellularly and forms homo-oligomers, but does not bind asialo-orosomucoid. (PubMed id 12089159)1, 9 Saxena A....Weigel P.H. (J. Biol. Chem. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 433 HGNC: 743 AceView: ASGR2 Ensembl:ENSG00000161944 euGenes: HUgn433
    ECgene: ASGR2 Kegg: 433 H-InvDB: ASGR2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ASGR2 Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_216

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ASGR2 gene:
    Search GeneIP for patents involving ASGR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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