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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ASGR1 Gene

protein-coding   GIFtS: 56
GCID: GC17M007017

asialoglycoprotein receptor 1
 Explore 7 diseases affiliated with
ASGR1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ASGR1    

Aliases
for ASGR1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Asialoglycoprotein Receptor 11 2     ASGPR2
CLEC4H11 2 3     ASGPR12
Hepatic Lectin H12 3     ASGP-R 13
HL-12 3     ASGPR 13
C-Type Lectin Domain Family 4 Member H12 3     

External Ids:    HGNC: 7421   Entrez Gene: 4322   Ensembl: ENSG000001415057   OMIM: 1083605   UniProtKB: P073063   

Export aliases for ASGR1 gene to outside databases

Previous GC identifers: GC17M007468 GC17P007746 GC17M007020 GC17M007277 GC17M006970


Summaries
for ASGR1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ASGR1:
This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a
critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of
glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may
facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug
delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which
are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively
spliced transcript variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Jan
2011)

UniProtKB/Swiss-Prot: ASGR1_HUMAN, P07306
Function: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex
carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units.
After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle,
where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface




Genomic Views
for ASGR1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ASGR1 gene promoter:
         SREBP-1a   Pax-6   HSF1short   HSF1 (long)   c-Myb   ARP-1   ZID   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ASGR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ASGR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASGR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.2   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13-p11

ASGR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASGR1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M007017:  view genomic region     (about GC identifiers)

Start:
 7,076,750 bp from pter      End:
 7,082,883 bp from pter
Size:
 6,134 bases      Orientation:
 minus strand

Proteins
for ASGR1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ASGR1_HUMAN, P07306 (See protein sequence)
Recommended Name: Asialoglycoprotein receptor 1  
Size: 291 amino acids; 33186 Da
Subunit: Interacts with LASS2
Subcellular location: Isoform H1a: Membrane; Single-pass type II membrane protein
Subcellular location: Isoform H1b: Secreted
Miscellaneous: Calcium is required for ligand binding
1 PDB 3D structure from and Proteopedia for ASGR1:
1DV8 (3D)    
Secondary accessions: I3L1X1
Alternative splicing: 2 isoforms:  P07306-1   P07306-2   

Explore the universe of human proteins at neXtProt for ASGR1: NX_P07306

Post-translational modifications:

  • Phosphorylated on a cytoplasmic Ser residue1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P07306

    • ASGR1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001184145.1  NP_001662.1  

    ENSEMBL proteins: 
     ENSP00000269299   ENSP00000370307   ENSP00000467511   ENSP00000459169   ENSP00000458530  
     ENSP00000458803   ENSP00000459896  

    Human Recombinant Protein Products: 
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    OriGene Purified Protein: ASGR1
    OriGene Protein Over-expression Lysate (see all 2): ASGR1
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    Novus Biologicals ASGR1 Protein
    Novus Biologicals ASGR1 Lysate
    Sino Biological Recombinant Protein for ASGR1
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ASGR1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005887integral to plasma membrane TAS10734069


    ASGR1 for ontologies           About GeneDecksing



    ASGR1 Antibody Products: 
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    Uscn Antibodies for ASGR1
    ThermoFisher Antibodies for ASGR1

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    Uscn ELISAs and CLIAs for ASGR1

    Protein Domains /
    Families
    for ASGR1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ASGR1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR016187 C-type_lectin_fold
     IPR018378 C-type_lectin_CS
     IPR016186 C-type_lectin-like
     IPR005640 Lectin_N
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry P07306

    ProtoNet protein and cluster: P07306

    2 Blocks protein families:
    IPB002353 Type II antifreeze protein signature
    IPB005640 Hepatic lectin


    UniProtKB/Swiss-Prot: ASGR1_HUMAN, P07306
    Similarity: Contains 1 C-type lectin domain


    Function
    for ASGR1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ASGR1_HUMAN, P07306
    Function: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex
    carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units.
    After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle,
    where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface

         Genatlas biochemistry entry for ASGR1:
    asialoglycoprotein receptor 1

    miRNA
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    Inhib. RNA
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    OriGene shRNA RFP: ASGR1
    OriGene siRNA: ASGR1
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    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASGR1 

    Cell Line
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    Search LifeMap BioReagents cell lines for ASGR1

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004873asialoglycoprotein receptor activity IEA--
    GO:0005515protein binding IPI--
    GO:0030246carbohydrate binding IEA--
    GO:0042803protein homodimerization activity IEA--
    GO:0046872metal ion binding IEA--


    ASGR1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for ASGR1:
     Increased gamma-H2AX phosphory  Metaphase cells 

    Animal Models:
         Mouse knock-outs for ASGR1: Asgr1tm1Ishi Asgr1tm1Sau
         5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Asgr1):
     hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system  mortality/aging 

    ASGR1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ASGR1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ASGR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/11 Interacting proteins for ASGR1 (P073061, 3 ENSP000002692994) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CERS2Q96G231, 3, ENSP000002716884EBI-1172335,EBI-1057080 I2D: score=3 STRING: ENSP00000271688
    CLEC4GQ6UXB43, ENSP000003275994I2D: score=2 STRING: ENSP00000327599
    NLKQ9UBE83, ENSP000003846254I2D: score=2 STRING: ENSP00000384625
    RBBP6Q7Z6E93, ENSP000003178724I2D: score=2 STRING: ENSP00000317872
    TGP012663, ENSP000002206164I2D: score=1 STRING: ENSP00000220616
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006898receptor-mediated endocytosis TAS8439566
    GO:0031668cellular response to extracellular stimulus IEA--


    ASGR1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ASGR1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ASGR1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ASGR1

    1 HMDB Compound for ASGR1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    1 Novoseek chemical compound relationship for ASGR1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rapamycin 35.9 1 12167617 (1)

    Search CenterWatch for drugs/clinical trials and news about ASGR1 

    Transcripts
    for ASGR1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ASGR1 gene (2 alternative transcripts): 
    NM_001197216.2  NM_001671.4  

    Unigene Cluster for ASGR1:

    Asialoglycoprotein receptor 1
    Hs.12056  [show with all ESTs]
    Unigene Representative Sequence: NM_001671
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000269299(uc002ges.4 uc021toy.1) ENST00000380920 ENST00000574330(uc010clx.1)
    ENST00000574388 ENST00000572879 ENST00000570576 ENST00000573596 ENST00000573083


    miRNA
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    Inhib. RNA
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    OriGene shRNA RFP: ASGR1
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK308375.1 BC032130.2 BT019873.1 CR542052.1 FJ410292.1 M10058.1 

    5 DOTS entries:

    DT.442753  DT.95159334  DT.100781521  DT.86849966  DT.91945459 

    24/58 AceView cDNA sequences (see all 58):

    BM818592 BC032130 BI252226 CR542052 NM_001671 CB153785 BQ064480 BQ646882 
    AV684219 BE463979 AI026918 CD612451 AA843575 BQ653541 BX422291 AV647837 
    AK124286 BX478532 AV683107 T28282 CD612448 BU727612 BX096034 BI915017 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ASGR1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10
    SP1:                    -     -     -                                                                     
    SP2:                          -     -                                                                     
    SP3:                    -     -     -     -                                                               
    SP4:                    -     -     -     -     -                                                         
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for ASGR1

    Expression
    for ASGR1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ASGR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACCAAGGAGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ASGR1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryAntral FollicleCumulus CellsOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium
    Hepatocyte-like cells (Functional hepatocyt...)

    See ASGR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ASGR1

    SOURCE GeneReport for Unigene cluster: Hs.12056

    UniProtKB/Swiss-Prot: ASGR1_HUMAN, P07306
    Tissue specificity: Expressed exclusively in hepatic parenchymal cells

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    In Situ
    Assay Products:     
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    Orthologs
    for ASGR1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ASGR1 gene from 2/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 37(a)
    		 1 → many
    		 AAWZ02038207(3409-8479)
    zebrafish
    (Danio rerio)    		 Actinopterygii si:ch211-283g2.56
    si:ch73-361h17.16
    (see all 5)    		 si:ch73-361h17.1
    (see all 5)    		 27(a)
    26(a)
    (see all 5)    		 many ↔ many
    many ↔ many
    (see all 5)    		 5(4216874-4227037)
    23(45443907-45457012)


    ENSEMBL Gene Tree for ASGR1 (if available)
    TreeFam Gene Tree for ASGR1 (if available) 

    Paralogs
    for ASGR1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ASGR1 gene
    CD2072  CLEC4E2  ASGR22  CLEC4M2  CLEC4F2  CD2092  CLEC10A2  FCER22  
    CLEC4A2  CLEC6A2  CLEC4C2  CLEC4D2  CLEC4G2  
    15 SIMAP similar genes for ASGR1 using alignment to 7 protein entries:     ASGR1_HUMAN (see all proteins):
    HBXBP    CLEC10A    ASGR2    KLRG1    FCER2    CLEC2D
    KLRF1    CLEC4C    KLRC1    NCAN    CLEC2L    CLEC4E
    OLR1    REG1A    REG1B

    ASGR1 for paralogs           About GeneDecksing



    Genomic Variants
    for ASGR1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/226 NCBI SNPs in ASGR1 are shown (see all 226)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1381700211,2
    		--7076257(+) CCGAGC/GGGGGC 2 -- ds50010--------
    rs1140692341,2
    		--7076289(+) TCGAGG/ACCAGC 2 -- ds50011Minor allele frequency- A:0.01WA 118
    rs1426194361,2
    		--7076349(+) CCGGGC/TGTGAT 2 -- ds50010--------
    rs1913546371,2
    		--7076415(+) ACCCGA/GGGGGC 2 -- ds50010--------
    rs3661171,2
    		--7076471(+) gcaacA/Ggagca 2 -- ds50010--------
    rs1831666401,2
    		--7076499(+) AAAAAA/TATTCG 2 -- ds50010--------
    rs1492774691,2
    		--7076598(+) TTGCCA/CAAACT 2 -- ds50010--------
    rs2002058201,2
    		--7076761(+) TATAT-/TTCTTTTT 2 -- ut310--------
    rs598925761,2
    		C--7076775(+) AAAAAA/-GTTCA 2 -- ut311Minor allele frequency- -:0.00NA 2
    rs1113547661,2
    		F,--7076837(+) AGCTCC/TTCACC 2 -- ut313Minor allele frequency- T:0.04CSA WA 122

    HapMap Linkage Disequilibrium report for ASGR1 (7076750 - 7082883 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 7 variations for ASGR1
         3 CNVs: 77514 88337 72785
         4 Indels: 88338 77515 77516 88339

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    Disorders / Diseases
    for ASGR1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ASGR1 for disorders           About GeneDecksing

    OMIM gene information: 108360    OMIM disorders: --

    7 diseases for ASGR1:    About MalaCards
    hepatitis    hepatitis b    autoimmune hepatitis    hepatitis c
    colon carcinoma    hepatocellular carcinoma    carcinoma

    2 diseases from the University of Copenhagen DISEASES database for ASGR1:
    Autoimmune hepatitis     Hepatitis

    1 Novoseek disease relationship for ASGR1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatitis b 17.7 1 16475991 (1)


    Export disorders for ASGR1 gene to outside databases

    Publications
    for ASGR1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ASGR1 gene, integrated from 9 sources (see all 56):
    (articles sorted by number of sources associating them with ASGR1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A new splice variant of the major subunit of human as ialoglycoprotein receptor encodes a secreted form in hepatocytes. (PubMed id 20886072)1, 2 Liu J....Yang D. (2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1. (PubMed id 11543633)1, 2 Pan H....Gu J.-R. (2001)
    4. Crystal structure of the carbohydrate recognition domain of the H1 subunit of the asialoglycoprotein receptor. (PubMed id 10891274)1, 2 Meier M.... Burkhard P. (2000)
    5. An internal signal sequence: the asialoglycoprotein receptor membrane anchor. (PubMed id 3753585)1, 2 Spiess M. and Lodish H.F. (1986)
    6. Sequence of human asialoglycoprotein receptor cDNA. An internal signal sequence for membrane insertion. (PubMed id 2982798)1, 2 Spiess M.... Lodish H.F. (1985)
    7. Potentiation of proliferation of some but not all hum an colon carcinoma cell lines by immobilized hepatic asialoglycoprotein recepto r 1. (PubMed id 19725223)1, 9 Fang J....Irimura T. (2009)
    8. Nonpalmitoylated human asialoglycoprotein receptors recycle constitutively but are defective in coated pit-mediated endocytosis, dissociation, and delivery of ligand to lysosomes. (PubMed id 12171918)1, 9 Yik J.H....Weigel P.H. (2002)
    9. Phosphorylation-dependent interaction of the asialoglycoprotein receptor with molecular chaperones. (PubMed id 12167617)1, 9 Huang T....Stockert R.J. (2002)
    10. Antisense oligonucleotides targeted against asialoglycoprotein receptor 1 block human hepatitis B virus replication. (PubMed id 16475991)1, 9 Yang J....Wang S.Q. (2006)

    External Searches for ASGR1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ASGR1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 432 HGNC: 742 AceView: ASGR1 Ensembl:ENSG00000141505 euGenes: HUgn432
    ECgene: ASGR1 H-InvDB: ASGR1

    Other Databases showing ASGR1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ASGR1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ASGR1 Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_215

    Intellectual Property
    for ASGR1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ASGR1 gene:
    Search GeneIP for patents involving ASGR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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