Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ASGR1 Gene

Aliases for ASGR1 Gene

  • Asialoglycoprotein Receptor 1 2 3
  • C-Type Lectin Domain Family 4 Member H1 3 4
  • Hepatic Lectin H1 3 4
  • CLEC4H1 3 4
  • HL-1 3 4
  • ASGP-R 1 4
  • ASGPR 1 4
  • ASGPR1 3
  • ASGPR 3

External Ids for ASGR1 Gene

Summaries for ASGR1 Gene

Entrez Gene Summary for ASGR1 Gene

  • This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for ASGR1 Gene

ASGR1 (Asialoglycoprotein Receptor 1) is a Protein Coding gene. Diseases associated with ASGR1 include hepatitis b and hepatitis. Among its related pathways are Insulin secretion. GO annotations related to this gene include protein homodimerization activity and asialoglycoprotein receptor activity. An important paralog of this gene is CLEC4D.

UniProtKB/Swiss-Prot for ASGR1 Gene

  • Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASGR1 Gene

Genomics for ASGR1 Gene

Genomic Location for ASGR1 Gene

Start:
7,173,431 bp from pter
End:
7,179,564 bp from pter
Size:
6,134 bases
Orientation:
Minus strand

Genomic View for ASGR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ASGR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASGR1 Gene

Regulatory Elements for ASGR1 Gene

Proteins for ASGR1 Gene

  • Protein details for ASGR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07306-ASGR1_HUMAN
    Recommended name:
    Asialoglycoprotein receptor 1
    Protein Accession:
    P07306
    Secondary Accessions:
    • I3L1X1

    Protein attributes for ASGR1 Gene

    Size:
    291 amino acids
    Molecular mass:
    33186 Da
    Quaternary structure:
    • Interacts with LASS2.
    Miscellaneous:
    • Calcium is required for ligand binding

    Three dimensional structures from OCA and Proteopedia for ASGR1 Gene

    Alternative splice isoforms for ASGR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASGR1 Gene

Proteomics data for ASGR1 Gene at MOPED

Post-translational modifications for ASGR1 Gene

No data available for DME Specific Peptides for ASGR1 Gene

Domains for ASGR1 Gene

Gene Families for ASGR1 Gene

HGNC:
  • CLEC :C-type lectin domain containing

UniProtKB/Swiss-Prot:

ASGR1_HUMAN
Domain:
  • Contains 1 C-type lectin domain.:
    • P07306
genes like me logo Genes that share domains with ASGR1: view

Function for ASGR1 Gene

Molecular function for ASGR1 Gene

GENATLAS Biochemistry: asialoglycoprotein receptor 1
UniProtKB/Swiss-Prot Function: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface

Gene Ontology (GO) - Molecular Function for ASGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004873 asialoglycoprotein receptor activity TAS 8439566
GO:0005515 protein binding IPI 11543633
GO:0030246 carbohydrate binding IEA --
GO:0042803 protein homodimerization activity --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ASGR1: view
genes like me logo Genes that share phenotypes with ASGR1: view

Animal Models for ASGR1 Gene

MGI Knock Outs for ASGR1:

miRNA for ASGR1 Gene

miRTarBase miRNAs that target ASGR1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ASGR1 Gene

Localization for ASGR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ASGR1 Gene

Isoform H1a: Membrane; Single-pass type II membrane protein.
Isoform H1b: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ASGR1 Gene COMPARTMENTS Subcellular localization image for ASGR1 gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytosol 2
endosome 2
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ASGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005887 integral component of plasma membrane TAS 10734069
genes like me logo Genes that share ontologies with ASGR1: view

Pathways for ASGR1 Gene

SuperPathways for ASGR1 Gene

Superpath Contained pathways
1 Insulin secretion
genes like me logo Genes that share pathways with ASGR1: view

Pathways by source for ASGR1 Gene

1 KEGG pathway for ASGR1 Gene

Gene Ontology (GO) - Biological Process for ASGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis TAS 8439566
GO:0031668 cellular response to extracellular stimulus --
genes like me logo Genes that share ontologies with ASGR1: view

Compounds for ASGR1 Gene

(1) HMDB Compounds for ASGR1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Novoseek inferred chemical compound relationships for ASGR1 Gene

Compound -log(P) Hits PubMed IDs
rapamycin 35.9 1
genes like me logo Genes that share compounds with ASGR1: view

Transcripts for ASGR1 Gene

Unigene Clusters for ASGR1 Gene

Asialoglycoprotein receptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ASGR1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - - - - -
SP5:
SP6: -

Relevant External Links for ASGR1 Gene

GeneLoc Exon Structure for
ASGR1
ECgene alternative splicing isoforms for
ASGR1

Expression for ASGR1 Gene

mRNA expression in normal human tissues for ASGR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ASGR1 Gene

This gene is overexpressed in Liver (45.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ASGR1 Gene

SOURCE GeneReport for Unigene cluster for ASGR1 Gene Hs.12056

mRNA Expression by UniProt/SwissProt for ASGR1 Gene

P07306-ASGR1_HUMAN
Tissue specificity: Expressed exclusively in hepatic parenchymal cells
genes like me logo Genes that share expressions with ASGR1: view

Orthologs for ASGR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ASGR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ASGR1 36
  • 99.87 (n)
  • 99.62 (a)
ASGR1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ASGR1 36
  • 84.93 (n)
  • 81.14 (a)
ASGR1 37
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 26 (a)
ManyToMany
ASGR1 36
  • 85.92 (n)
  • 84.51 (a)
mouse
(Mus musculus)
Mammalia Asgr1 36
  • 81.81 (n)
  • 78.87 (a)
Asgr1 16
Asgr1 37
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ASGR1 37
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Asgr1 36
  • 81.69 (n)
  • 80.28 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 39 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch211-283g2.2 37
  • 30 (a)
ManyToMany
si:ch211-283g2.3 37
  • 22 (a)
ManyToMany
si:ch73-361h17.1 37
  • 27 (a)
ManyToMany
Species with no ortholog for ASGR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ASGR1 Gene

ENSEMBL:
Gene Tree for ASGR1 (if available)
TreeFam:
Gene Tree for ASGR1 (if available)

Paralogs for ASGR1 Gene

genes like me logo Genes that share paralogs with ASGR1: view

Variants for ASGR1 Gene

Sequence variations from dbSNP and Humsavar for ASGR1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs314259 -- 7,180,569(-) ttatt(A/T)ttttt upstream-variant-2KB
rs366117 -- 7,173,152(+) gcaac(A/G)gagca downstream-variant-500B
rs436481 -- 7,176,643(-) tgtgg(A/G)tgtga intron-variant
rs1222784 -- 7,180,460(-) tcctg(C/T)ctcag upstream-variant-2KB
rs1222785 -- 7,180,366(-) gttgg(C/T)caggc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ASGR1 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv457659 CNV Loss 19166990
esv2665200 CNV Deletion 23128226
esv28478 CNV Loss 19812545

Relevant External Links for ASGR1 Gene

HapMap Linkage Disequilibrium report
ASGR1

Disorders for ASGR1 Gene

(2) MalaCards Diseases for ASGR1 Gene

Search for ASGR1 Gene in MalaCards »

(2) University of Copenhagen DISEASES for ASGR1 Gene

(1) Novoseek inferred disease relationships for ASGR1 Gene

Disease -log(P) Hits PubMed IDs
hepatitis b 17.7 1

Relevant External Links for ASGR1

Genetic Association Database (GAD)
ASGR1
genes like me logo Genes that share disorders with ASGR1: view

No data available for UniProtKB/Swiss-Prot for ASGR1 Gene

Publications for ASGR1 Gene

  1. Fatty acylation of the rat and human asialoglycoprotein receptors. A conserved cytoplasmic cysteine residue is acylated in all receptor subunits. (PMID: 8943311) Zeng F.Y. … Weigel P.H. (J. Biol. Chem. 1996) 4 23
  2. Phosphorylation-dependent interaction of the asialoglycoprotein receptor with molecular chaperones. (PMID: 12167617) Huang T. … Stockert R.J. (J. Biol. Chem. 2002) 3 23
  3. Nonpalmitoylated human asialoglycoprotein receptors recycle constitutively but are defective in coated pit-mediated endocytosis, dissociation, and delivery of ligand to lysosomes. (PMID: 12171918) Yik J.H. … Weigel P.H. (J. Biol. Chem. 2002) 3 23
  4. The position of cysteine relative to the transmembrane domain is critical for palmitoylation of H1, the major subunit of the human asialoglycoprotein receptor. (PMID: 12370180) Yik J.H. … Weigel P.H. (J. Biol. Chem. 2002) 3 23
  5. Assignment of human asialoglycoprotein receptor gene (ASGR1) to chromosome 17p11-13. (PMID: 1774077) Sanford J.P. … Shows T.B. (Genomics 1991) 3 23

Products for ASGR1 Gene

Sources for ASGR1 Gene

Back to Top

Content