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ASGR1 Gene

protein-coding   GIFtS: 61
GCID: GC17M007017

Asialoglycoprotein Receptor 1

  See ASGR1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Asialoglycoprotein Receptor 11 2     ASGPR2
Hepatic Lectin H12 3     ASGPR12
CLEC4H12 3     ASGP-R 13
HL-12 3     ASGPR 13
C-Type Lectin Domain Family 4 Member H12 3     

External Ids:    HGNC: 7421   Entrez Gene: 4322   Ensembl: ENSG000001415057   OMIM: 1083605   UniProtKB: P073063   

Export aliases for ASGR1 gene to outside databases

Previous GC identifers: GC17M007468 GC17P007746 GC17M007020 GC17M007277 GC17M006970


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ASGR1 Gene:
This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that
plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of
glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor
may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for
liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major
and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant
major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this
gene. (provided by RefSeq, Jan 2011)

GeneCards Summary for ASGR1 Gene:
ASGR1 (asialoglycoprotein receptor 1) is a protein-coding gene. Diseases associated with ASGR1 include hepatitis b, and hepatitis. GO annotations related to this gene include asialoglycoprotein receptor activity and protein homodimerization activity. An important paralog of this gene is CD207.

UniProtKB/Swiss-Prot: ASGR1_HUMAN, P07306
Function: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their
complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and
N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and
transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the
cell membrane surface




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ASGR1 gene promoter:
         SREBP-1a   Pax-6   HSF1short   HSF1 (long)   c-Myb   ARP-1   ZID   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidASGR1 promoter sequence
   Search Chromatin IP Primers for ASGR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ASGR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.2   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13-p11

ASGR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASGR1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M007017:  view genomic region     (about GC identifiers)

Start:
7,076,750 bp from pter      End:
7,082,883 bp from pter
Size:
6,134 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ASGR1_HUMAN, P07306 (See protein sequence)
Recommended Name: Asialoglycoprotein receptor 1  
Size: 291 amino acids; 33186 Da
Subunit: Interacts with LASS2
Miscellaneous: Calcium is required for ligand binding
1 PDB 3D structure from and Proteopedia for ASGR1:
1DV8 (3D)    
Secondary accessions: I3L1X1
Alternative splicing: 2 isoforms:  P07306-1   P07306-2   

Explore the universe of human proteins at neXtProt for ASGR1: NX_P07306

Explore proteomics data for ASGR1 at MOPED

Post-translational modifications: 

  • Phosphorylated on a cytoplasmic Ser residue1
  • Glycosylation2 at Asn79, Asn147
  • Modification sites at PhosphoSitePlus

  • See ASGR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001184145.1  NP_001662.1  

    ENSEMBL proteins: 
     ENSP00000269299   ENSP00000370307   ENSP00000467511   ENSP00000459169   ENSP00000458530  
     ENSP00000458803   ENSP00000459896  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CLEC: C-type lectin domain containing

    5 InterPro protein domains:
     IPR005640 Lectin_N
     IPR016187 C-type_lectin_fold
     IPR018378 C-type_lectin_CS
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry P07306

    ProtoNet protein and cluster: P07306

    2 Blocks protein domains:
    IPB002353 Type II antifreeze protein signature
    IPB005640 Hepatic lectin


    UniProtKB/Swiss-Prot: ASGR1_HUMAN, P07306
    Similarity: Contains 1 C-type lectin domain


    Find genes that share domains with ASGR1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ASGR1_HUMAN, P07306
    Function: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their
    complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and
    N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and
    transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the
    cell membrane surface

         Genatlas biochemistry entry for ASGR1:
    asialoglycoprotein receptor 1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004873asialoglycoprotein receptor activity IEA--
    GO:0005515protein binding IPI11543633
    GO:0030246carbohydrate binding IEA--
    GO:0042803protein homodimerization activity IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ASGR1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ASGR1:
     Increased gamma-H2AX phosphory  Metaphase cells 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Asgr1):
     hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system  mortality/aging 

    Find genes that share phenotypes with ASGR1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ASGR1: Asgr1tm1Ishi Asgr1tm1Sau

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ASGR1
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    hsa-mir-335-5p (MIRT018208)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ASGR1_HUMAN, P07306: Isoform H1a: Membrane; Single-pass type II membrane protein
    ASGR1_HUMAN, P07306: Isoform H1b: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane4
    cytosol2
    endosome2
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1
    vacuole1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005887integral component of plasma membrane TAS10734069

    Find genes that share ontologies with ASGR1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ASGR1 About    
    See pathways by source

    SuperPathContained pathways About
    1Insulin secretion
    Thyroid hormone synthesis0.36


    Find genes that share SuperPaths with ASGR1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for ASGR1):
        Thyroid hormone synthesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ASGR1
    Interactions:

        Search GeneGlobe Interaction Network for ASGR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for ASGR1 (P073061, 3 ENSP000002692994) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CERS2Q96G231, 3, ENSP000002716884EBI-1172335,EBI-1057080 I2D: score=3 STRING: ENSP00000271688
    CLEC4GQ6UXB43, ENSP000003275994I2D: score=2 STRING: ENSP00000327599
    NLKQ9UBE83, ENSP000003846254I2D: score=2 STRING: ENSP00000384625
    RBBP6Q7Z6E93, ENSP000003178724I2D: score=2 STRING: ENSP00000317872
    TGP012663, ENSP000002206164I2D: score=1 STRING: ENSP00000220616
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006898receptor-mediated endocytosis TAS8439566
    GO:0031668cellular response to extracellular stimulus IEA--

    Find genes that share ontologies with ASGR1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ASGR1

    1 HMDB Compound for ASGR1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 Novoseek inferred chemical compound relationship for ASGR1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rapamycin 35.9 1 12167617 (1)



    Find genes that share compounds with ASGR1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ASGR1 gene (2 alternative transcripts): 
    NM_001197216.2  NM_001671.4  

    Unigene Cluster for ASGR1:

    Asialoglycoprotein receptor 1
    Hs.12056  [show with all ESTs]
    Unigene Representative Sequence: NM_001671
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000269299(uc002ges.4 uc021toy.1) ENST00000380920 ENST00000574330(uc010clx.1)
    ENST00000574388 ENST00000572879 ENST00000570576 ENST00000573596 ENST00000573083

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    Additional mRNA sequence: 

    AK308375.1 BC032130.2 BT019873.1 CR542052.1 FJ410292.1 M10058.1 

    5 DOTS entries:

    DT.442753  DT.95159334  DT.100781521  DT.86849966  DT.91945459 

    Selected AceView cDNA sequences (see all 58):

    BI252226 BM818592 CR542052 NM_001671 CB153785 BQ646882 BQ064480 BC032130 
    BU727612 BQ653541 CD612451 AK124286 AV684219 T28282 AI223318 BX422291 
    AA857545 BX096034 AI026918 CD612450 BM823081 AV683107 AV647837 BI915017 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ASGR1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10
    SP1:                    -     -     -                                                                     
    SP2:                          -     -                                                                     
    SP3:                    -     -     -     -                                                               
    SP4:                    -     -     -     -     -                                                         
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for ASGR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ASGR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCAAGGAGT
    ASGR1 Expression
    About this image


    ASGR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Hepatocytes Liver Lobule
             Hepatocyte-like cells
     
     Ovary (Reproductive System)
             Cumulus Cells Antral Follicle
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
     
     Brain (Nervous System)
             Cerebellum
    ASGR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ASGR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.12056

    UniProtKB/Swiss-Prot: ASGR1_HUMAN, P07306
    Tissue specificity: Expressed exclusively in hepatic parenchymal cells

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ASGR1 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Asgr11 , 5 asialoglycoprotein receptor 11, 5 81.81(n)1
    78.87(a)1
      11 (42.98 cM)5
    118891  NM_009714.21  NP_033844.11 
     700540855 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    39(a)
    1 → many
    AAWZ02038207(3409-9140)
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-283g2.26
    si:ch73-361h17.16
    (see all 3)
    si:ch73-361h17.1
    (see all 3)
    30(a)
    27(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    5(4216874-4227037) ENSDARG00000069025
    23(45443907-45457012) ENSDARG00000095963


    ENSEMBL Gene Tree for ASGR1 (if available)
    TreeFam Gene Tree for ASGR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ASGR1 gene
    CD2072  CLEC17A2  CLEC4E2  ASGR22  CLEC4M2  CLEC4F2  CD2092  CLEC4A2  
    FCER22  CLEC10A2  CLEC6A2  CLEC4C2  CLEC4D2  CLEC4G2  
    15 SIMAP similar genes for ASGR1 using alignment to 7 protein entries:     ASGR1_HUMAN (see all proteins):
    HBXBP    CLEC10A    ASGR2    KLRG1    FCER2    CLEC2D
    KLRF1    CLEC4C    KLRC1    NCAN    CLEC2L    CLEC4E
    OLR1    REG1A    REG1B

    Find genes that share paralogs with ASGR1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ASGR1 (see all 315)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1381700211,2
    --7076257(+) CCGAGC/GGGGGC 2 -- ds50010--------
    rs1140692341,2
    C,F--7076289(+) TCGAGG/ACCAGC 2 -- ds50011Minor allele frequency- A:0.01WA 118
    rs1426194361,2
    C--7076349(+) CCGGGC/TGTGAT 2 -- ds50010--------
    rs1913546371,2
    --7076415(+) ACCCGA/GGGGGC 2 -- ds50010--------
    rs3661171,2
    C--7076471(+) gcaacA/Ggagca 2 -- ds50010--------
    rs1831666401,2
    --7076499(+) AAAAAA/TATTCG 2 -- ds50010--------
    rs1492774691,2
    --7076598(+) TTGCCA/CAAACT 2 -- ds50010--------
    rs2002058201,2
    C--7076761(+) TATAT-/TTCTTTTT 2 -- cds10--------
    rs598925761,2
    C--7076774(+) AAAAAA/-GTTCA 2 -- ut312Minor allele frequency- -:0.25NA CSA 4
    rs1113547661,2
    F--7076837(+) AGCTCC/TTCACC 2 -- ut313Minor allele frequency- T:0.04CSA WA 122

    HapMap Linkage Disequilibrium report for ASGR1 (7076750 - 7082883 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ASGR1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665200CNV Deletion23128226
    esv2422288CNV Deletion17116639
    esv28478CNV Loss19812545
    nsv457659CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 108360    OMIM disorders: --

    2 diseases for ASGR1:    
    About MalaCards
    hepatitis b    hepatitis

    2 diseases from the University of Copenhagen DISEASES database for ASGR1:
    Autoimmune hepatitis     Hepatitis

    Find genes that share disorders with ASGR1           About GenesLikeMe

    1 Novoseek inferred disease relationship for ASGR1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatitis b 17.7 1 16475991 (1)

    Genetic Association Database (GAD): ASGR1

    Export disorders for ASGR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ASGR1 gene, integrated from 10 sources (see all 61):
    (articles sorted by number of sources associating them with ASGR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. (PubMed id 22001757)1, 4 Chambers J.C....Kooner J.S. (Nat. Genet. 2011)
    2. A new splice variant of the major subunit of human asialoglycoprotein receptor encodes a secreted form in hepatocytes. (PubMed id 20886072)1, 2 Liu J....Yang D. (PLoS ONE 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1. (PubMed id 11543633)1, 2 Pan H....Gu J.-R. (Genomics 2001)
    5. Crystal structure of the carbohydrate recognition domain of the H1 subunit of the asialoglycoprotein receptor. (PubMed id 10891274)1, 2 Meier M.... Burkhard P. (J. Mol. Biol. 2000)
    6. An internal signal sequence: the asialoglycoprotein receptor membrane anchor. (PubMed id 3753585)1, 2 Spiess M. and Lodish H.F. (Cell 1986)
    7. Sequence of human asialoglycoprotein receptor cDNA. An internal signal sequence for membrane insertion. (PubMed id 2982798)1, 2 Spiess M.... Lodish H.F. (J. Biol. Chem. 1985)
    8. Potentiation of proliferation of some but not all human colon carcinoma cell lines by immobilized hepatic asialoglycoprotein receptor 1. (PubMed id 19725223)1, 9 Fang J....Irimura T. (Oncol. Res. 2009)
    9. Nonpalmitoylated human asialoglycoprotein receptors recycle constitutively but are defective in coated pit-mediated endocytosis, dissociation, and delivery of ligand to lysosomes. (PubMed id 12171918)1, 9 Yik J.H....Weigel P.H. (J. Biol. Chem. 2002)
    10. Phosphorylation-dependent interaction of the asialoglycoprotein receptor with molecular chaperones. (PubMed id 12167617)1, 9 Huang T....Stockert R.J. (J. Biol. Chem. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 432 HGNC: 742 AceView: ASGR1 Ensembl:ENSG00000141505 euGenes: HUgn432
    ECgene: ASGR1 Kegg: 432 H-InvDB: ASGR1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ASGR1 Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_215

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ASGR1 gene:
    Search GeneIP for patents involving ASGR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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