Aliases for ASF1A Gene
External Ids for ASF1A Gene
Previous GeneCards Identifiers for ASF1A Gene
This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair. [provided by RefSeq, Jul 2008]
GeneCards Summary for ASF1A Gene
ASF1A (Anti-Silencing Function 1A Histone Chaperone) is a Protein Coding gene. Among its related pathways are DNA Damage/Telomere Stress Induced Senescence and Cellular Senescence (REACTOME). GO annotations related to this gene include chromatin binding and histone binding. An important paralog of this gene is ASF1B.
UniProtKB/Swiss-Prot for ASF1A Gene
Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.