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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ASF1A Gene

protein-coding   GIFtS: 55
GCID: GC06P119215

Anti-Silencing Function 1A Histone Chaperone

(Previous name: ASF1 anti-silencing function 1 homolog A (S. cerevisiae))
Microbiology & Infectious Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Anti-Silencing Function 1A Histone Chaperone1 2     hCIA2 3
CIA2 3 5     ASF1 Anti-Silencing Function 1 Homolog A (S. Cerevisiae)1
Anti-Silencing Function Protein 1 Homolog A2 3     CGI-982
CCG1-Interacting Factor A2 3     HSPC1462
hAsf12 3     ASF1 Anti-Silencing Function 1 Homolog A2
hAsf1a2 3     Histone Chaperone ASF1A2

External Ids:    HGNC: 209951   Entrez Gene: 258422   Ensembl: ENSG000001118757   OMIM: 6091895   UniProtKB: Q9Y2943   

Export aliases for ASF1A gene to outside databases

Previous GC identifers: GC06P119157 GC06P119202 GC06P119192 GC06P119263 GC06P116797


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ASF1A Gene:
This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing
function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome
assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during
DNA replication and repair. (provided by RefSeq, Jul 2008)

GeneCards Summary for ASF1A Gene: 
ASF1A (anti-silencing function 1A histone chaperone) is a protein-coding gene. Diseases associated with ASF1A include nijmegen breakage syndrome, and herpes simplex. GO annotations related to this gene include chromatin binding and histone binding. An important paralog of this gene is ASF1B.

UniProtKB/Swiss-Prot: ASF1A_HUMAN, Q9Y294
Function: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome
assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent
chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the
formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle
exit

Gene Wiki entry for ASF1A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ASF1A gene promoter:
         FOXI1   HFH-3   TBP   S8   AP-1   TFIID   FOXD3   Nkx2-5   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidASF1A promoter sequence
   Search SABiosciences Chromatin IP Primers for ASF1A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASF1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.31   Ensembl cytogenetic band:  6q22.31   HGNC cytogenetic band: 6q22.31

ASF1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASF1A gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P119215:  view genomic region     (about GC identifiers)

Start:
119,215,241 bp from pter      End:
119,230,336 bp from pter
Size:
15,096 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ASF1A_HUMAN, Q9Y294 (See protein sequence)
Recommended Name: Histone chaperone ASF1A  
Size: 204 amino acids; 22969 Da
Subunit: Interacts with histone H3 (including both histone H3.1 and H3.3) and histone H4. Interacts with the
CHAF1A, CHAF1B and RBBP4 subunits of the CAF-1 complex. Interacts with CABIN1, HAT1, HIRA, NASP, TAF1, TLK1, TLK2
and UBN1. Interacts with CDAN1. Found in a cytosolic complex with CDAN1, ASF1B, IPO4 and histones H3.1 and H4
Subcellular location: Nucleus
5 PDB 3D structures from and Proteopedia for ASF1A:
1TEY (3D)        2I32 (3D)        2IIJ (3D)        2IO5 (3D)        3AAD (3D)    
Secondary accessions: Q6IA08 Q9P014

Explore the universe of human proteins at neXtProt for ASF1A: NX_Q9Y294

Explore proteomics data for ASF1A at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by TLK1 and TLK2. Highly phosphorylated in S-phase and at lower levels in M-phase. TLK2-mediated
    phosphorylation at Ser-192 prevents proteasome-dependent degradation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y294

  • ASF1A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ASF1A Protein Expression
    REFSEQ proteins: NP_054753.1  
    ENSEMBL proteins: 
     ENSP00000229595  

    Human Recombinant Protein Products for ASF1A: 
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    Cloud-Clone Corp. Proteins for ASF1A 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS10759893

    ASF1A for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR006818 Histone_chaperone_ASF1-like

    Graphical View of Domain Structure for InterPro Entry Q9Y294

    ProtoNet protein and cluster: Q9Y294

    UniProtKB/Swiss-Prot: ASF1A_HUMAN, Q9Y294
    Similarity: Belongs to the ASF1 family


    ASF1A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ASF1A_HUMAN, Q9Y294
    Function: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome
    assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent
    chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the
    formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle
    exit

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding NAS10759893
    GO:0005515protein binding IPI--
    GO:0042393histone binding IDA10759893
         
    ASF1A for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Asf1a):
     mortality/aging 

    ASF1A for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ASF1A 
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    SwitchGear 3'UTR luciferase reporter plasmidASF1A 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ASF1A About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for ASF1A
        Chromatin Regulation / Acetylation




    ASF1A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ASF1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/277 Interacting proteins for ASF1A (Q9Y2941, 2, 3 ENSP000002295954) via UniProtKB, MINT, STRING, and/or I2D (see all 277)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4BP628052, 3MINT-7220359 I2D: score=14 
    HIST1H4CP628052, 3MINT-7220359 I2D: score=14 
    HIST1H4DP628052, 3MINT-7220359 I2D: score=14 
    HIST1H4EP628052, 3MINT-7220359 I2D: score=14 
    HIST1H4HP628052, 3MINT-7220359 I2D: score=14 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001649osteoblast differentiation IEA--
    GO:0006281DNA repair IDA11897662
    GO:0006333chromatin assembly or disassembly ----
    GO:0006334nucleosome assembly IDA11897662
    GO:0006351transcription, DNA-dependent IEA--

    ASF1A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ASF1A

    Search CenterWatch for drugs/clinical trials and news about ASF1A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ASF1A gene: 
    NM_014034.2  

    Unigene Cluster for ASF1A:

    ASF1 anti-silencing function 1 homolog A (S. cerevisiae)
    Hs.292316  [show with all ESTs]
    Unigene Representative Sequence: NM_014034
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000229595(uc011ebn.2) ENST00000511766
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/62 QIAGEN miScript miRNA Assays for microRNAs that regulate ASF1A (see all 62):
    hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-4307 hsa-miR-429 hsa-miR-106a hsa-miR-513a-5p hsa-miR-139-5p
    SwitchGear 3'UTR luciferase reporter plasmidASF1A 3' UTR sequence
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    Additional mRNA sequence: 

    AB028628.1 AF151856.1 AF161495.1 AF279306.1 AK025738.1 AL050261.1 BC010878.1 CR457347.1 

    8 DOTS entries:

    DT.100689111  DT.117413  DT.100816997  DT.75171446  DT.100021621  DT.109974  DT.121331893  DT.117415 

    24/126 AceView cDNA sequences (see all 126):

    AA215824 AA452418 AA766866 AA599659 AI701568 AA481056 BF055992 CA944529 
    BU627432 AI419304 BQ086365 AW662437 AI424191 CA447803 T54544 AW511824 
    BU689220 CK823008 AW473313 AI131522 CA868478 BF055488 BF939523 CR610395 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ASF1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATTCTGAGT
    ASF1A Expression
    About this image


    See ASF1A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ASF1A

    SOURCE GeneReport for Unigene cluster: Hs.292316

    UniProtKB/Swiss-Prot: ASF1A_HUMAN, Q9Y294
    Tissue specificity: Ubiquitously expressed

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ASF1A gene from 10/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Asf1a1 , 5 ASF1 anti-silencing function 1 homolog A (S. cerevisiae)1, 5 94.77(n)1
    99.51(a)1
      10 (27.24 cM)5
    664031  NM_025541.31  NP_079817.11 
     535969615 
    chicken
    (Gallus gallus)
    Aves ASF1A1 ASF1 anti-silencing function 1 homolog A (S. cerevisiae) 90.2(n)
    100(a)
      723780  NM_001044690.1  NP_001038155.1 
    lizard
    (Anolis carolinensis)
    Reptilia ASF1A6
    Uncharacterized protein
    99(a)
    1 ↔ 1
    1(184835657-184842838)
    African clawed frog
    (Xenopus laevis)
    Amphibia asf1a-prov2 ASF1 anti-silencing function 1 homolog A (S. cerevisiae) 76.81(n)    BC056123.1 
    zebrafish
    (Danio rerio)
    Actinopterygii asf1bb1 ASF1 anti-silencing function 1 homolog Bb 67.85(n)
    76.65(a)
      792029  NM_214757.2  NP_999922.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta asf11 anti-silencing factor 1 60.76(n)
    67.19(a)
      40141  NM_001202202.1  NP_001189131.1 
    worm
    (Caenorhabditis elegans)
    Secernentea asfl-11 Protein ASFL-1 53.37(n)
    50.92(a)
      172812  NM_060166.4  NP_492567.3 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ASF11 Asf1p 59.07(n)
    57.59(a)
      853327   NP_012420.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ASF1B1 histone chaperone ASF1B 58.8(n)
    56.74(a)
      833791  NM_123171.3  NP_198627.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g05538001 hypothetical protein 59.5(n)
    55.81(a)
      4339550  NM_001062800.1  NP_001056265.1 


    ENSEMBL Gene Tree for ASF1A (if available)
    TreeFam Gene Tree for ASF1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ASF1A gene
    ASF1B2  
    1 SIMAP similar gene for ASF1A using alignment to 1 protein entry:     ASF1A_HUMAN:
    ASF1B

    ASF1A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ASF1A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509151CNV Insertion20534489
    nsv510910CNV Complex20534489

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609189    OMIM disorders: --

    2 diseases for ASF1A:    About MalaCards
    nijmegen breakage syndrome    herpes simplex


    ASF1A for disorders           About GeneDecksing

    Genetic Association Database (GAD): ASF1A
    Human Genome Epidemiology (HuGE) Navigator: ASF1A (1 document)

    Export disorders for ASF1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ASF1A gene, integrated from 9 sources (see all 68):
    (articles sorted by number of sources associating them with ASF1A)
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    1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.H....Lin W. (2000)
    2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (2000)
    3. A human homologue of yeast anti-silencing factor has histone chaperone activity. (PubMed id 10759893)1, 2, 9 Munakata T.... Horikoshi M. (2000)
    4. Structural basis for the interaction of Asf1 with histone H3 and its functional implications. (PubMed id 15840725)1, 2, 9 Mousson F....Ochsenbein F. (2005)
    5. Codanin-1, mutated in the anaemic disease CDAI, regula tes Asf1 function in S-phase histone supply. (PubMed id 22407294)1, 2 Ask K....Groth A. (2012)
    6. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    7. Phosphorylation-mediated control of histone chaperone ASF1 levels by Tousled-like kinases. (PubMed id 20016786)1, 2 Pilyugin M....Moshkin Y.M. (2009)
    8. Common variants at ten loci influence QT interval duration in the QTGEN Study. (PubMed id 19305408)1, 4 Newton-Cheh C....Stricker B.H. (2009)
    9. Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells. (PubMed id 19029251)1, 2 Banumathy G....Adams P.D. (2008)
    10. Structure of a human ASF1a-HIRA complex and insights into specificity of histone chaperone complex assembly. (PubMed id 16980972)1, 2 Tang Y.... Marmorstein R. (2006)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25842 HGNC: 20995 AceView: ASF1A Ensembl:ENSG00000111875 euGenes: HUgn25842
    ECgene: ASF1A H-InvDB: ASF1A

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ASF1A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ASF1A gene:
    Search GeneIP for patents involving ASF1A

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