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Aliases for ASF1A Gene

Aliases for ASF1A Gene

  • Anti-Silencing Function 1A Histone Chaperone 2 3
  • CIA 3 4 6
  • Anti-Silencing Function Protein 1 Homolog A 3 4
  • CCG1-Interacting Factor A 3 4
  • HAsf1a 3 4
  • HAsf1 3 4
  • HCIA 3 4
  • ASF1 Anti-Silencing Function 1 Homolog A (S. Cerevisiae) 2
  • ASF1 Anti-Silencing Function 1 Homolog A 3
  • Histone Chaperone ASF1A 3
  • HSPC146 3
  • CGI-98 3

External Ids for ASF1A Gene

Summaries for ASF1A Gene

Entrez Gene Summary for ASF1A Gene

  • This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair. [provided by RefSeq, Jul 2008]

GeneCards Summary for ASF1A Gene

ASF1A (Anti-Silencing Function 1A Histone Chaperone) is a Protein Coding gene. Among its related pathways are Cellular Senescence and Chromatin Regulation / Acetylation. GO annotations related to this gene include chromatin binding and histone binding. An important paralog of this gene is ASF1B.

UniProtKB/Swiss-Prot for ASF1A Gene

  • Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.

Gene Wiki entry for ASF1A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASF1A Gene

Genomics for ASF1A Gene

Genomic Location for ASF1A Gene

Start:
118,894,077 bp from pter
End:
118,909,171 bp from pter
Size:
15,095 bases
Orientation:
Plus strand

Genomic View for ASF1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ASF1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASF1A Gene

Regulatory Elements for ASF1A Gene

Proteins for ASF1A Gene

  • Protein details for ASF1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y294-ASF1A_HUMAN
    Recommended name:
    Histone chaperone ASF1A
    Protein Accession:
    Q9Y294
    Secondary Accessions:
    • Q6IA08
    • Q9P014

    Protein attributes for ASF1A Gene

    Size:
    204 amino acids
    Molecular mass:
    22969 Da
    Quaternary structure:
    • Interacts with histone H3 (including both histone H3.1 and H3.3) and histone H4. Interacts with the CHAF1A, CHAF1B and RBBP4 subunits of the CAF-1 complex. Interacts with CABIN1, HAT1, HIRA, NASP, TAF1, TLK1, TLK2 and UBN1. Interacts with CDAN1. Found in a cytosolic complex with CDAN1, ASF1B, IPO4 and histones H3.1 and H4. Interacts with CREBBP.

    Three dimensional structures from OCA and Proteopedia for ASF1A Gene

neXtProt entry for ASF1A Gene

Proteomics data for ASF1A Gene at MOPED

Post-translational modifications for ASF1A Gene

  • Phosphorylated by TLK1 and TLK2. Highly phosphorylated in S-phase and at lower levels in M-phase. TLK2-mediated phosphorylation at Ser-192 prevents proteasome-dependent degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ASF1A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ASF1A Gene

Domains for ASF1A Gene

Protein Domains for ASF1A Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

ASF1A_HUMAN
Family:
  • Belongs to the ASF1 family.:
    • Q9Y294
genes like me logo Genes that share domains with ASF1A: view

No data available for Gene Families for ASF1A Gene

Function for ASF1A Gene

Molecular function for ASF1A Gene

UniProtKB/Swiss-Prot Function: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.

Gene Ontology (GO) - Molecular Function for ASF1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding NAS 10759893
GO:0005515 protein binding IPI 19862764
GO:0042393 histone binding IDA 10759893
genes like me logo Genes that share ontologies with ASF1A: view

Phenotypes for ASF1A Gene

MGI mutant phenotypes for ASF1A:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with ASF1A: view

miRNA for ASF1A Gene

miRTarBase miRNAs that target ASF1A

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ASF1A Gene

Localization for ASF1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ASF1A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ASF1A Gene COMPARTMENTS Subcellular localization image for ASF1A gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ASF1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 14718166
GO:0005634 nucleus NAS 10759893
GO:0005654 nucleoplasm TAS --
GO:0043234 protein complex IDA 14718166
genes like me logo Genes that share ontologies with ASF1A: view

Pathways for ASF1A Gene

genes like me logo Genes that share pathways with ASF1A: view

Pathways by source for ASF1A Gene

Gene Ontology (GO) - Biological Process for ASF1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IEA --
GO:0006281 DNA repair IDA 11897662
GO:0006333 chromatin assembly or disassembly --
GO:0006334 nucleosome assembly IDA 11897662
GO:0006335 DNA replication-dependent nucleosome assembly IDA 14718166
genes like me logo Genes that share ontologies with ASF1A: view

Transcripts for ASF1A Gene

mRNA/cDNA for ASF1A Gene

Unigene Clusters for ASF1A Gene

ASF1 anti-silencing function 1 homolog A (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ASF1A Gene

No ASD Table

Relevant External Links for ASF1A Gene

GeneLoc Exon Structure for
ASF1A
ECgene alternative splicing isoforms for
ASF1A

Expression for ASF1A Gene

mRNA expression in normal human tissues for ASF1A Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ASF1A Gene

SOURCE GeneReport for Unigene cluster for ASF1A Gene Hs.292316

mRNA Expression by UniProt/SwissProt for ASF1A Gene

Q9Y294-ASF1A_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with ASF1A: view

Orthologs for ASF1A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ASF1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ASF1A 36
  • 94.58 (n)
  • 93.56 (a)
ASF1A 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ASF1A 36
  • 96.08 (n)
  • 99.51 (a)
ASF1A 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ASF1A 36
  • 97.55 (n)
  • 100 (a)
ASF1A 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Asf1a 36
  • 94.77 (n)
  • 99.51 (a)
Asf1a 16
Asf1a 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ASF1A 37
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ASF1A 37
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Asf1a 36
  • 91.99 (n)
  • 98.04 (a)
chicken
(Gallus gallus)
Aves ASF1A 36
  • 90.2 (n)
  • 100 (a)
ASF1A 37
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ASF1A 37
  • 99 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia asf1a-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia asf1b 36
  • 68.17 (n)
  • 77.39 (a)
zebrafish
(Danio rerio)
Actinopterygii asf1bb 36
  • 67.85 (n)
  • 76.65 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005920 36
  • 64.52 (n)
  • 75.48 (a)
fruit fly
(Drosophila melanogaster)
Insecta asf1 36
  • 60.24 (n)
  • 65.48 (a)
asf1 37
  • 56 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea asfl-1 36
  • 54.98 (n)
  • 53.25 (a)
asfl-1 37
  • 35 (a)
ManyToMany
unc-85 37
  • 31 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ASF1 36
  • 59.07 (n)
  • 57.59 (a)
ASF1 37
  • 35 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ASF1B 36
  • 60.59 (n)
  • 60.38 (a)
rice
(Oryza sativa)
Liliopsida Os05g0553800 36
  • 62.96 (n)
  • 61.44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 50 (a)
OneToMany
Species with no ortholog for ASF1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ASF1A Gene

ENSEMBL:
Gene Tree for ASF1A (if available)
TreeFam:
Gene Tree for ASF1A (if available)

Paralogs for ASF1A Gene

Paralogs for ASF1A Gene

Selected SIMAP similar genes for ASF1A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ASF1A: view

Variants for ASF1A Gene

Structural Variations from Database of Genomic Variants (DGV) for ASF1A Gene

Variant ID Type Subtype PubMed ID
nsv509151 CNV Insertion 20534489
nsv510910 CNV Complex 20534489

Relevant External Links for ASF1A Gene

HapMap Linkage Disequilibrium report
ASF1A

No data available for Sequence variations from dbSNP and Humsavar for ASF1A Gene

Disorders for ASF1A Gene

Relevant External Links for ASF1A

Genetic Association Database (GAD)
ASF1A
Human Genome Epidemiology (HuGE) Navigator
ASF1A
genes like me logo Genes that share disorders with ASF1A: view

No data available for UniProtKB/Swiss-Prot for ASF1A Gene

Publications for ASF1A Gene

  1. A human homologue of yeast anti-silencing factor has histone chaperone activity. (PMID: 10759893) Munakata T. … Horikoshi M. (Genes Cells 2000) 3 4 23
  2. Structural basis for the interaction of Asf1 with histone H3 and its functional implications. (PMID: 15840725) Mousson F. … Ochsenbein F. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 4 23
  3. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4
  4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4
  5. Structure and function of the histone chaperone CIA/ASF1 complexed with histones H3 and H4. (PMID: 17293877) Natsume R. … Senda T. (Nature 2007) 3 23

Products for ASF1A Gene

  • Addgene plasmids for ASF1A

Sources for ASF1A Gene

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