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Aliases for ASCL5 Gene

Aliases for ASCL5 Gene

  • Achaete-Scute Family BHLH Transcription Factor 5 2 3
  • Class A Basic Helix-Loop-Helix Protein 47 3 4
  • BHLHa47 3 4
  • ASH-5 3 4
  • HASH5 3 4
  • Achaete-Scute Complex Homolog 5 (Drosophila) 2
  • Achaete-Scute Complex Homolog 5 3
  • Achaete-Scute Homolog 5 3

External Ids for ASCL5 Gene

Previous GeneCards Identifiers for ASCL5 Gene

  • GC01M199352
  • GC01M201085
  • GC01M201086
  • GC01M172250
  • GC01M201087
  • GC01M201090
  • GC01M201091
  • GC01M201092

Summaries for ASCL5 Gene

GeneCards Summary for ASCL5 Gene

ASCL5 (Achaete-Scute Family BHLH Transcription Factor 5) is a Protein Coding gene. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is ASCL4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASCL5 Gene

Genomics for ASCL5 Gene

Regulatory Elements for ASCL5 Gene

Genomic Location for ASCL5 Gene

201,113,953 bp from pter
201,127,184 bp from pter
13,232 bases
Minus strand

Genomic View for ASCL5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ASCL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASCL5 Gene

Proteins for ASCL5 Gene

  • Protein details for ASCL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Achaete-scute homolog 5
    Protein Accession:
    Secondary Accessions:

    Protein attributes for ASCL5 Gene

    278 amino acids
    Molecular mass:
    29462 Da
    Quaternary structure:
    No Data Available
    • Sequence=DAA00301.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ASCL5 Gene

Proteomics data for ASCL5 Gene at MOPED

Post-translational modifications for ASCL5 Gene

No Post-translational modifications

Other Protein References for ASCL5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ASCL5 Gene

Domains for ASCL5 Gene

Gene Families for ASCL5 Gene

  • bHLH :Basic helix-loop-helix proteins

Protein Domains for ASCL5 Gene

Suggested Antigen Peptide Sequences for ASCL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q7RTU5
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with ASCL5: view

Function for ASCL5 Gene

Gene Ontology (GO) - Molecular Function for ASCL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003677 DNA binding IEA --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with ASCL5: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ASCL5

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ASCL5 Gene

Localization for ASCL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ASCL5 Gene

Gene Ontology (GO) - Cellular Components for ASCL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ASCL5: view

No data available for Subcellular locations from COMPARTMENTS for ASCL5 Gene

Pathways for ASCL5 Gene

SuperPathways for ASCL5 Gene

No Data Available

Interacting Proteins for ASCL5 Gene

Gene Ontology (GO) - Biological Process for ASCL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ASCL5: view

No data available for Pathways by source for ASCL5 Gene

Transcripts for ASCL5 Gene

mRNA/cDNA for ASCL5 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ASCL5 Gene

Achaete-scute complex homolog 5 (Drosophila):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ASCL5

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ASCL5 Gene

No ASD Table

Relevant External Links for ASCL5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ASCL5 Gene

mRNA expression in normal human tissues for ASCL5 Gene

mRNA differential expression in normal tissues according to GTEx for ASCL5 Gene

This gene is overexpressed in Pancreas (7.9).

Protein differential expression in normal tissues for ASCL5 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ASCL5 Gene

SOURCE GeneReport for Unigene cluster for ASCL5 Gene Hs.721460

genes like me logo Genes that share expressions with ASCL5: view

Expression partners for ASCL5 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ASCL5 Gene

Orthologs for ASCL5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ASCL5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ASCL5 35
  • 82.22 (n)
  • 75 (a)
(Canis familiaris)
Mammalia ASCL5 35
  • 79.14 (n)
  • 70.75 (a)
(Mus musculus)
Mammalia Ascl5 35
  • 82.34 (n)
  • 78.92 (a)
Ascl5 16
Ascl5 36
  • 66 (a)
(Pan troglodytes)
Mammalia LOC100614803 35
  • 99.19 (n)
  • 98.06 (a)
(Rattus norvegicus)
Mammalia Ascl5 35
  • 81.62 (n)
  • 78.92 (a)
(Ornithorhynchus anatinus)
Mammalia ASCL5 36
  • 64 (a)
(Danio rerio)
Actinopterygii LOC101887049 35
  • 65.93 (n)
  • 74.44 (a)
(Caenorhabditis elegans)
Secernentea hlh-6 36
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
Species with no ortholog for ASCL5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ASCL5 Gene

Gene Tree for ASCL5 (if available)
Gene Tree for ASCL5 (if available)

Paralogs for ASCL5 Gene

Paralogs for ASCL5 Gene

Selected SIMAP similar genes for ASCL5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ASCL5: view

Variants for ASCL5 Gene

Sequence variations from dbSNP and Humsavar for ASCL5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2274236 -- 201,114,802(-) AGTCC(C/T)CCTGC missense, reference
rs7516023 -- 201,116,393(+) CTCTG(C/T)CTGGC upstream-variant-2KB
rs10494826 -- 201,116,868(-) AGTCC(C/T)GATCA upstream-variant-2KB
rs11586813 -- 201,115,582(+) CTCAG(A/G)AGGTC upstream-variant-2KB
rs12079819 -- 201,116,292(+) GATTA(A/G)CAGCA upstream-variant-2KB

Relevant External Links for ASCL5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ASCL5 Gene

Disorders for ASCL5 Gene

No disorders were found for ASCL5 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ASCL5 Gene

Publications for ASCL5 Gene

  1. Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening. (PMID: 14516699) McLellan A.S. … Kealey T. (Mech. Dev. 2002) 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4

Products for ASCL5 Gene

Sources for ASCL5 Gene

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