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Aliases for ASCL5 Gene

Aliases for ASCL5 Gene

  • Achaete-Scute Family BHLH Transcription Factor 5 2 3 5
  • Class A Basic Helix-Loop-Helix Protein 47 3 4
  • BHLHa47 3 4
  • ASH-5 3 4
  • HASH5 3 4
  • Achaete-Scute Complex Homolog 5 (Drosophila) 2
  • Achaete-Scute Complex Homolog 5 3
  • Achaete-Scute Homolog 5 3

External Ids for ASCL5 Gene

Previous GeneCards Identifiers for ASCL5 Gene

  • GC01M199352
  • GC01M201085
  • GC01M201086
  • GC01M172250
  • GC01M201087
  • GC01M201090
  • GC01M201091
  • GC01M201092

Summaries for ASCL5 Gene

GeneCards Summary for ASCL5 Gene

ASCL5 (Achaete-Scute Family BHLH Transcription Factor 5) is a Protein Coding gene. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is ASCL4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASCL5 Gene

Genomics for ASCL5 Gene

Regulatory Elements for ASCL5 Gene

Enhancers for ASCL5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F201113 0.8 ENCODE 47.5 +12.9 12929 1.0 PKNOX1 SIN3A ZNF48 ZNF2 GLIS2 ELK1 ZNF143 DEK ZNF263 ZHX2 ASCL5 CACNA1S GC01P201114
GH01F201126 0.9 Ensembl ENCODE 44.4 -0.5 -470 2.2 PKNOX1 KLF17 RAD21 RARA SCRT2 FOS EGR2 CEBPB ZNF623 KAT8 ASCL5 TMEM9
GH01F201110 0.7 Ensembl ENCODE 42 +15.3 15284 2.2 ZNF263 CTCF ZNF26 BHLHE40 MNT ZIC2 ZNF18 ASCL5 CACNA1S TMEM9 GC01M201077
GH01F201111 0.4 Ensembl 31.2 +16.6 16584 0.4 BHLHE40 MNT ZNF18 ASCL5 CACNA1S GC01M201077
GH01F201124 0.6 ENCODE 12.6 +1.6 1597 1.7 ZFHX2 ZNF740 KDM1A ZIC2 ZNF623 NR2F2 EGR2 ASCL5 TMEM9 IGFN1 ENSG00000234132 GPR25 GC01P201114
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ASCL5 on UCSC Golden Path with GeneCards custom track

Genomic Location for ASCL5 Gene

Chromosome:
1
Start:
201,113,953 bp from pter
End:
201,127,184 bp from pter
Size:
13,232 bases
Orientation:
Minus strand

Genomic View for ASCL5 Gene

Genes around ASCL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASCL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASCL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASCL5 Gene

Proteins for ASCL5 Gene

  • Protein details for ASCL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTU5-ASCL5_HUMAN
    Recommended name:
    Achaete-scute homolog 5
    Protein Accession:
    Q7RTU5

    Protein attributes for ASCL5 Gene

    Size:
    278 amino acids
    Molecular mass:
    29462 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=DAA00301.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ASCL5 Gene

Post-translational modifications for ASCL5 Gene

No Post-translational modifications

Other Protein References for ASCL5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ASCL5 Gene

Domains & Families for ASCL5 Gene

Gene Families for ASCL5 Gene

Protein Domains for ASCL5 Gene

Suggested Antigen Peptide Sequences for ASCL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7RTU5

UniProtKB/Swiss-Prot:

ASCL5_HUMAN :
  • Contains 1 bHLH (basic helix-loop-helix) domain.
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with ASCL5: view

Function for ASCL5 Gene

Gene Ontology (GO) - Molecular Function for ASCL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0003674 molecular_function ND --
GO:0003677 DNA binding IEA --
GO:0003700 contributes_to transcription factor activity, sequence-specific DNA binding IBA --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with ASCL5: view

Phenotypes for ASCL5 Gene

GenomeRNAi human phenotypes for ASCL5:
genes like me logo Genes that share phenotypes with ASCL5: view

Animal Model Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ASCL5 Gene

Localization for ASCL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ASCL5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ASCL5 Gene COMPARTMENTS Subcellular localization image for ASCL5 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ASCL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
GO:0090575 RNA polymerase II transcription factor complex IBA --
genes like me logo Genes that share ontologies with ASCL5: view

Pathways & Interactions for ASCL5 Gene

SuperPathways for ASCL5 Gene

No Data Available

Interacting Proteins for ASCL5 Gene

Gene Ontology (GO) - Biological Process for ASCL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ASCL5: view

No data available for Pathways by source and SIGNOR curated interactions for ASCL5 Gene

Transcripts for ASCL5 Gene

mRNA/cDNA for ASCL5 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ASCL5 Gene

Achaete-scute complex homolog 5 (Drosophila):
Representative Sequences:

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ASCL5 Gene

No ASD Table

Relevant External Links for ASCL5 Gene

GeneLoc Exon Structure for
ASCL5
ECgene alternative splicing isoforms for
ASCL5

Expression for ASCL5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ASCL5 Gene

mRNA differential expression in normal tissues according to GTEx for ASCL5 Gene

This gene is overexpressed in Pancreas (x7.9).

Protein differential expression in normal tissues from HIPED for ASCL5 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ASCL5 Gene



Protein tissue co-expression partners for ASCL5 Gene

NURSA nuclear receptor signaling pathways regulating expression of ASCL5 Gene:

ASCL5

SOURCE GeneReport for Unigene cluster for ASCL5 Gene:

Hs.721460
genes like me logo Genes that share expression patterns with ASCL5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ASCL5 Gene

Orthologs for ASCL5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ASCL5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100614803 34
  • 99.19 (n)
mouse
(Mus musculus)
Mammalia Ascl5 34 16 35
  • 82.34 (n)
cow
(Bos Taurus)
Mammalia ASCL5 34
  • 82.22 (n)
rat
(Rattus norvegicus)
Mammalia Ascl5 34
  • 81.62 (n)
dog
(Canis familiaris)
Mammalia ASCL5 34
  • 79.14 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ASCL5 35
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC101887049 34
  • 65.93 (n)
worm
(Caenorhabditis elegans)
Secernentea hlh-6 35
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 20 (a)
OneToMany
Species where no ortholog for ASCL5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ASCL5 Gene

ENSEMBL:
Gene Tree for ASCL5 (if available)
TreeFam:
Gene Tree for ASCL5 (if available)

Paralogs for ASCL5 Gene

Paralogs for ASCL5 Gene

(1) SIMAP similar genes for ASCL5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ASCL5: view

Variants for ASCL5 Gene

Sequence variations from dbSNP and Humsavar for ASCL5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10494826 -- 201,116,868(-) AGTCC(C/T)GATCA upstream-variant-2KB
rs10920123 -- 201,113,609(+) gcatt(C/T)tacta downstream-variant-500B, upstream-variant-2KB
rs111326937 -- 201,115,297(+) GGGCA(C/T)GACGC reference, missense
rs111332210 -- 201,113,990(+) GTGCC(A/G)ACGCA upstream-variant-2KB, utr-variant-3-prime
rs112085020 -- 201,116,212(+) CTTGA(C/G)ACTGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ASCL5 Gene

Variant ID Type Subtype PubMed ID
nsv428301 CNV gain 18775914

Variation tolerance for ASCL5 Gene

Gene Damage Index Score: 7.31; 81.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ASCL5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ASCL5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASCL5 Gene

Disorders for ASCL5 Gene

Relevant External Links for ASCL5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ASCL5

No disorders were found for ASCL5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASCL5 Gene

Publications for ASCL5 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 64
  2. Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening. (PMID: 14516699) McLellan A.S. … Kealey T. (Mech. Dev. 2002) 4 64

Products for ASCL5 Gene

Sources for ASCL5 Gene

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