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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ASCL5 Gene

protein-coding   GIFtS: 26
GCID: GC01M201094

Achaete-Scute Complex Homolog 5 (Drosophila)

  Search for ASCL5
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Achaete-Scute Complex Homolog 5 (Drosophila)1 2     hASH52 3
Class A Basic Helix-Loop-Helix Protein 472 3     Achaete-Scute Homolog 52
ASH-52 3     BHLHA473
bHLHa472 3     

External Ids:    HGNC: 331691   Entrez Gene: 6472192   Ensembl: ENSG000002322377   UniProtKB: Q7RTU53   
ORGUL members:         
NONCODE14:n363736      

Export aliases for ASCL5 gene to outside databases

Previous GC identifers: GC01M199352 GC01M201085 GC01M201086 GC01M172250 GC01M201087 GC01M201090 GC01M201091 GC01M201092


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ASCL5 Gene: 
ASCL5 (achaete-scute complex homolog 5 (Drosophila)) is a protein-coding gene, and is affiliated with the lncRNA class. GO annotations related to this gene include protein dimerization activity and molecular_function. An important paralog of this gene is ASCL3.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ASCL5 gene promoter:
         HOXA9B   HOXA9   GR   GCNF   POU2F1   GCNF-1   POU2F1a   GR-alpha   Meis-1a   Meis-1   
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASCL5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.1

ASCL5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASCL5 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M201094:  view genomic region     (about GC identifiers)

Start:
201,083,081 bp from pter      End:
201,096,312 bp from pter
Size:
13,232 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ASCL5_HUMAN, Q7RTU5 (See protein sequence)
Recommended Name: Achaete-scute homolog 5  
Size: 278 amino acids; 29462 Da
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=DAA00301.1; Type=Erroneous initiation;

Explore the universe of human proteins at neXtProt for ASCL5: NX_Q7RTU5

ASCL5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

REFSEQ proteins: NP_001257530.1  
ENSEMBL proteins: 
 ENSP00000472681   ENSP00000469019  

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005575cellular_component ND--
GO:0005634nucleus IEA--

ASCL5 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
bHLH: Basic helix-loop-helix proteins

2 InterPro protein domains:
 IPR015660 ASH
 IPR011598 bHLH_dom

Graphical View of Domain Structure for InterPro Entry Q7RTU5

ProtoNet protein and cluster: Q7RTU5

1 Blocks protein domain: IPB001092 Basic helix-loop-helix dimerization domain bHLH

UniProtKB/Swiss-Prot: ASCL5_HUMAN, Q7RTU5
Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


ASCL5 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003674molecular_function ND--
GO:0003677DNA binding IEA--
GO:0046983protein dimerization activity IEA--
     
ASCL5 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ASCL5

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-dependent IEA--
GO:0006355regulation of transcription, DNA-dependent IEA--
GO:0008150biological_process ND--

ASCL5 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
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Search CenterWatch for drugs/clinical trials and news about ASCL5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ASCL5 gene: 
NM_001270601.1  

Unigene Cluster for ASCL5:

Achaete-scute complex homolog 5 (Drosophila)
Hs.721460  [show with all ESTs]
Unigene Representative Sequence: NM_001270601
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000449188 ENST00000458416
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1 DOTS entry:

DT.65287214 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ASCL5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
ASCL5 Expression
About this image


SOURCE GeneReport for Unigene cluster: Hs.721460
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for ASCL5 gene from 1/4 species (see all 4)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ascl55 achaete-scute complex homolog 5 (Drosophila), pseudogene   --   1 (59.54 cM) 136050803 


ENSEMBL Gene Tree for ASCL5 (if available)
TreeFam Gene Tree for ASCL5 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for ASCL5 gene
ASCL32  ASCL12  ASCL22  ASCL42  
1 SIMAP similar gene for ASCL5 using alignment to 2 protein entries:     ASCL5_HUMAN (see all proteins):
ASCL3

ASCL5 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/41 SNPs in ASCL5 are shown (see all 41)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1910663381,2
--201083758(+) CGCCGA/CGGACC 1 -- ut310--------
rs1806890781,2
--201083760(+) CCGCGA/GACCTC 1 -- ut310--------
rs1866543521,2
--201083822(+) GCTCCA/CGAAAG 1 -- ut310--------
rs570626681,2
C,F--201083886(+) CAATGC/GCAGGA 2 C W mis15Minor allele frequency- G:0.09CSA WA NA EA 360
rs22742361,2
C,F--201083930(-) AGTCCT/CCCTGC 2 /P /S mis12Minor allele frequency- C:0.09EA 1612
rs1113269371,2
C,F--201084425(+) GGGCAT/CGACGC 2 /M /V mis13Minor allele frequency- C:0.20CSA WA 120
rs125671201,2
C,F,H--201084540(+) CCACCG/AAATGG 1 -- us2k11Minor allele frequency- A:0.50NA 4
rs1901161681,2
--201084553(+) CCGGCG/TTGGGG 1 -- us2k10--------
rs802317141,2
C,F--201084589(+) AAGTCA/GCATCG 1 -- us2k12Minor allele frequency- G:0.11WA EA 238
rs115868131,2
H--201084710(+) CTCAGG/AAGGTC 1 -- us2k14Minor allele frequency- A:0.00NS EA 420

HapMap Linkage Disequilibrium report for ASCL5 (201083081 - 201096312 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for ASCL5: --
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for ASCL5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ASCL5)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
  2. Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening. (PubMed id 14516699)2 McLellan A.S.... Kealey T. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 647219 HGNC: 33169 Ensembl:ENSG00000232237 euGenes: HUgn647219 ECgene: ASCL5
H-InvDB: ASCL5

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for ASCL5 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for ASCL5 gene:
Search GeneIP for patents involving ASCL5

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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About This Section

 
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